CA2344269A1 - Proteines vegetales a action therapeutique - Google Patents

Proteines vegetales a action therapeutique Download PDF

Info

Publication number
CA2344269A1
CA2344269A1 CA002344269A CA2344269A CA2344269A1 CA 2344269 A1 CA2344269 A1 CA 2344269A1 CA 002344269 A CA002344269 A CA 002344269A CA 2344269 A CA2344269 A CA 2344269A CA 2344269 A1 CA2344269 A1 CA 2344269A1
Authority
CA
Canada
Prior art keywords
plant
protein
promoter
gene
host
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002344269A
Other languages
English (en)
Inventor
Peter Bernard Heifetz
Stephen Arthur Goff
Annmarie Bloom Tuttle
Monika Else Griot-Wenk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syngenta Participations AG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2344269A1 publication Critical patent/CA2344269A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
    • A01H5/00—Angiosperms, i.e. flowering plants, characterised by their plant parts; Angiosperms characterised otherwise than by their botanic taxonomy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
    • C12N15/8214—Plastid transformation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Abstract

La présente invention concerne des plantes transgéniques exprimant des protéines à action thérapeutique, de préférence à partir de leur génome plastidique ciblé sur la vacuole. L'invention concerne également l'administration de telles plantes transgéniques à des hôtes justifiant d'une telle thérapie à des fins de prévention ou de traitement d'affections. Selon une réalisation préférée, l'administration à l'hôte de telles plantes ou matières provenant de telles plantes se fait par voie orale.
CA002344269A 1998-10-07 1999-10-05 Proteines vegetales a action therapeutique Abandoned CA2344269A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US16736298A 1998-10-07 1998-10-07
US16823198A 1998-10-07 1998-10-07
US09/168,231 1998-10-07
US09/167,362 1998-10-07
PCT/EP1999/007414 WO2000020612A2 (fr) 1998-10-07 1999-10-05 Proteines vegetales a action therapeutique

Publications (1)

Publication Number Publication Date
CA2344269A1 true CA2344269A1 (fr) 2000-04-13

Family

ID=26863095

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002344269A Abandoned CA2344269A1 (fr) 1998-10-07 1999-10-05 Proteines vegetales a action therapeutique

Country Status (14)

Country Link
EP (1) EP1117817A2 (fr)
JP (1) JP2002526116A (fr)
KR (1) KR20010085901A (fr)
CN (1) CN1330718A (fr)
AR (1) AR020717A1 (fr)
AU (2) AU758817B2 (fr)
BR (1) BR9915919A (fr)
CA (1) CA2344269A1 (fr)
HU (1) HUP0103616A3 (fr)
IL (1) IL142041A0 (fr)
PL (1) PL347904A1 (fr)
RU (2) RU2001111881A (fr)
TR (1) TR200101032T2 (fr)
WO (1) WO2000020612A2 (fr)

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US20050032211A1 (en) * 1996-09-26 2005-02-10 Metabogal Ltd. Cell/tissue culturing device, system and method
IL155588A0 (en) * 2003-04-27 2003-11-23 Metabogal Ltd Methods for expression of enzymatically active recombinant lysosomal enzymes in transgenic plant root cells and vectors used thereby
US7361331B2 (en) * 1996-10-18 2008-04-22 Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Agriculture And Agri-Food Plant bioreactors
AU6277600A (en) * 1999-07-27 2001-02-13 Syngenta Participations Ag Novel chimeric genes
US7572466B1 (en) 1999-10-13 2009-08-11 Health Research, Inc. Oral immunology using plant product containing a non-enteric pathogen antigen
WO2001064929A1 (fr) * 2000-02-29 2001-09-07 Auburn University Production d'anticorps dans des plastes transgeniques
WO2001077353A2 (fr) * 2000-04-05 2001-10-18 Syngenta Participations Ag Proteines therapeutiquement actives dans des vegetaux
FR2809413B1 (fr) * 2000-05-29 2004-10-22 Tabacs & Allumettes Ind Production d'allergenes recombinants dans des cellules vegetales
JP2002017186A (ja) * 2000-06-30 2002-01-22 Hayashibara Biochem Lab Inc トランスジェニック植物
GB2364705A (en) * 2000-07-14 2002-02-06 Icgeb Fusion protein expression in plastids
BR0113156A (pt) 2000-08-11 2003-07-08 Syngenta Participations Ag Método para produzir um planta dicotiledÈnea transformada, célula de planta transformada, cultura de múltiplos brotos, planta transformada, semente produzida pela planta transformada, método para produzir uma planta compreendendo um genoma de plastìdeo transformado, genoma de plastìdeo transformado, e, plastìdeo
AU2002256205B2 (en) * 2001-04-13 2007-08-16 Boyce Thompson Institute For Plant Research Methods and compositions for stable transgenic plant pharmaceuticals and their use as contraceptives
US20040014174A1 (en) * 2002-04-23 2004-01-22 Mayfield Stephen P. Expression of polypeptides in chloroplasts, and compositions and methods for expressing same
FR2841906B1 (fr) * 2002-07-05 2006-08-18 Stallergenes Sa Molecule d'acide nucleique codant une preproproteine d'allergene d'un acarien du genre dermatophagoides ou euroglyphus et son utilisation pour la production dudit allergene dans les plantes
US7235711B2 (en) 2002-10-15 2007-06-26 Syngenta Participations Ag Plant cell plastid transformation method using dual selection and producing transplastomic plants without antibiotic resistance genes
ES2531125T3 (es) 2003-02-03 2015-03-10 Ibio Inc Sistema para la expresión de genes en plantas
CN1761754A (zh) * 2003-02-18 2006-04-19 辛根塔参与股份公司 在植物中表达抗肠产毒性大肠杆菌的抗体
GB0307989D0 (en) * 2003-04-07 2003-05-14 Mcewen Lab Ltd Therapeutic composition
US7951557B2 (en) 2003-04-27 2011-05-31 Protalix Ltd. Human lysosomal proteins from plant cell culture
WO2005026375A2 (fr) 2003-05-22 2005-03-24 Fraunhofer Usa, Inc. Molecule support recombinee pour l'expression, l'administration et la purification de polypeptides cibles
US8455717B2 (en) 2004-09-29 2013-06-04 Collplant Ltd. Collagen producing plants and methods of generating and using same
EP1904638A2 (fr) * 2005-07-18 2008-04-02 Metabogal Ltd. Administration mucosale ou enterale de macromolecules biologiquement actives
AU2012241058B2 (en) * 2005-07-18 2014-04-17 Protalix Ltd. Mucosal or Enteral Administration of Biologically Active Macromolecules
CA2616859C (fr) 2005-08-03 2015-04-14 Fraunhofer Usa, Inc. Compositions et procedes de production d'immunoglobulines
JP2009526526A (ja) 2006-02-13 2009-07-23 フラウンホーファー ユーエスエー， インコーポレイテッド インフルエンザ抗原、ワクチン組成物、および関連する方法
GB0604938D0 (en) 2006-03-11 2006-04-19 Renovo Ltd Proteins, nucleic acids and medicaments
GB0604964D0 (en) 2006-03-11 2006-04-19 Renovo Ltd Protein folding
GB0604966D0 (en) 2006-03-11 2006-04-19 Renovo Ltd Medicaments and proteins
GB0617816D0 (en) * 2006-09-11 2006-10-18 Renovo Ltd Nucleic acids and methods of protein expression
ES2660667T3 (es) 2007-05-07 2018-03-23 Protalix Ltd. Biorreactor desechable a gran escala
GB2449466B (en) * 2007-05-23 2009-11-18 Algentech Ltd Production of proteins in plant tissue
US8404252B2 (en) 2007-07-11 2013-03-26 Fraunhofer Usa, Inc. Yersinia pestis antigens, vaccine compositions, and related methods
WO2009058355A2 (fr) * 2007-10-31 2009-05-07 University Of Central Florida Research Foundation, Inc. Antigènes de vaccin humain dérivés du chloroplaste contre la malaria
SG193139A1 (en) * 2008-06-30 2013-09-30 Orf Liftaekni Hf Use of plant-derived recombinant growth factors in skin care
WO2010037046A1 (fr) 2008-09-28 2010-04-01 Fraunhofer Usa, Inc. Anticorps anti-neuraminidase humanisé et procédés d’utilisation de celui-ci
US9175300B2 (en) 2008-11-27 2015-11-03 Vanga Siva Reddy Method of expressing foreign protein in plastids
US9551005B2 (en) * 2009-07-16 2017-01-24 Kenneth John Piller Immunoassay for detecting thyroglobulin utilizing soybean produced recombinant thyroglobulin
WO2011041391A1 (fr) 2009-09-29 2011-04-07 Fraunhofer Usa, Inc. Anticorps dirigés contre l'hémagglutinine du virus de la grippe, compositions, et procédés associés
BR112012012563B1 (pt) * 2009-11-18 2021-10-05 Agriculture Victoria Services Pty Ltd Método para produzir uma célula de planta transformada que expressa um gene de angiogenina e construto artificial capaz de permitir a expressão de um gene de angiogenina em uma célula de planta
CN103906840B (zh) 2011-06-07 2018-01-30 艾比欧公司 重组蛋白通过与PNGase F共表达在活体内去糖基化
JP2013040138A (ja) * 2011-08-17 2013-02-28 Univ Of Tsukuba 活性化型リコンビナント花粉アレルゲンの作製方法
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JP6578283B2 (ja) 2014-02-12 2019-09-18 トランサルガエ イスラエル リミテッド 藻類をベースとした食用ワクチン
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Also Published As

Publication number Publication date
AU2003200126A1 (en) 2003-04-17
CN1330718A (zh) 2002-01-09
RU2003131696A (ru) 2005-04-20
BR9915919A (pt) 2001-08-21
KR20010085901A (ko) 2001-09-07
AR020717A1 (es) 2002-05-22
WO2000020612A3 (fr) 2000-07-06
HUP0103616A3 (en) 2003-07-28
IL142041A0 (en) 2002-03-10
RU2001111881A (ru) 2003-06-20
AU6334099A (en) 2000-04-26
HUP0103616A2 (hu) 2002-01-28
TR200101032T2 (tr) 2001-10-22
AU2003200126A9 (en) 2003-04-17
AU758817B2 (en) 2003-04-03
PL347904A1 (en) 2002-04-22
JP2002526116A (ja) 2002-08-20
WO2000020612A2 (fr) 2000-04-13
EP1117817A2 (fr) 2001-07-25

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued