CA2342207A1 - Calcium phosphate delivery vehicle and adjuvant - Google Patents
Calcium phosphate delivery vehicle and adjuvant Download PDFInfo
- Publication number
- CA2342207A1 CA2342207A1 CA002342207A CA2342207A CA2342207A1 CA 2342207 A1 CA2342207 A1 CA 2342207A1 CA 002342207 A CA002342207 A CA 002342207A CA 2342207 A CA2342207 A CA 2342207A CA 2342207 A1 CA2342207 A1 CA 2342207A1
- Authority
- CA
- Canada
- Prior art keywords
- adjuvant
- composition
- calcium phosphate
- beta
- particles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 title claims abstract description 169
- 239000001506 calcium phosphate Substances 0.000 title claims abstract description 167
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- A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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- A61L2430/00—Materials or treatment for tissue regeneration
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/153,133 US8333996B2 (en) | 1995-05-19 | 1998-09-15 | Calcium phosphate delivery vehicle and adjuvant |
| US09/153,133 | 1998-09-15 | ||
| PCT/US1999/021182 WO2000015194A1 (en) | 1998-09-15 | 1999-09-14 | Calcium phosphate delivery vehicle and adjuvant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2342207A1 true CA2342207A1 (en) | 2000-03-23 |
Family
ID=22545915
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002342207A Abandoned CA2342207A1 (en) | 1998-09-15 | 1999-09-14 | Calcium phosphate delivery vehicle and adjuvant |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8333996B2 (enExample) |
| EP (1) | EP1117381A4 (enExample) |
| JP (1) | JP2002524491A (enExample) |
| KR (2) | KR100756677B1 (enExample) |
| AU (1) | AU763487B2 (enExample) |
| CA (1) | CA2342207A1 (enExample) |
| NZ (1) | NZ510198A (enExample) |
| WO (1) | WO2000015194A1 (enExample) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL144084A0 (en) | 1999-02-03 | 2002-05-23 | Biosante Pharmaceuticals Inc | Therapeutic calcium phosphate particles and methods of manufacture and use |
| US20040258763A1 (en) * | 1999-02-03 | 2004-12-23 | Bell Steve J.D. | Methods of manufacture and use of calcium phosphate particles containing allergens |
| US20020068090A1 (en) * | 1999-02-03 | 2002-06-06 | Bell Steve J. D. | Calcium phosphate particles as mucosal adjuvants |
| EP1471034A3 (en) * | 1999-02-03 | 2005-03-02 | Biosante Pharmaceuticals, Inc. | Therapeutic calcium phosphate particles and methods of manufacture and use |
| US7857860B2 (en) * | 2003-04-30 | 2010-12-28 | Therics, Llc | Bone void filler and method of manufacture |
| EP1448246B2 (en) | 2001-11-19 | 2015-09-09 | Scil Technology GmbH | Method for producing a homogeneously coated device having osteoinductive and osteoconductive properties |
| AU2003253049A1 (en) * | 2002-09-10 | 2004-04-30 | Scil Technology Gmbh | Metal implant coated under reduced oxygen concentration with osteoinductive protein |
| FR2850282B1 (fr) | 2003-01-27 | 2007-04-06 | Jerome Asius | Implant injectable a base de ceramique pour le comblement de rides, depressions cutanees et cicatrices, et sa preparation |
| CA2516783A1 (en) * | 2003-02-21 | 2005-02-03 | Hasumi Llc (Dba Shukokai International) | Human lymphocyte vaccine adjuvant |
| US20040180091A1 (en) * | 2003-03-13 | 2004-09-16 | Chang-Yi Lin | Carbonated hydroxyapatite-based microspherical composites for biomedical uses |
| GB0307011D0 (en) | 2003-03-27 | 2003-04-30 | Regentec Ltd | Porous matrix |
| WO2004091435A2 (en) | 2003-04-11 | 2004-10-28 | Etex Corporation | Osteoinductive bone material |
| FR2856672A1 (fr) * | 2003-06-30 | 2004-12-31 | Rhodia Chimie Sa | Plaquettes de phosphate de calcium nanometrique. |
| FR2857268B1 (fr) * | 2003-07-08 | 2007-09-21 | Urodelia | Composite injectable pour magnetocytolyse de cellules metastatiques osseuses |
| CN1878565B (zh) * | 2003-09-12 | 2011-01-12 | 惠氏公司 | 用于递送成骨蛋白的注射型磷酸钙固体小棒剂和糊剂 |
| JP2007001865A (ja) * | 2003-09-16 | 2007-01-11 | Ltt Bio-Pharma Co Ltd | 脂溶性薬物封入微粒子、その製造法およびそれを含有する製剤 |
| WO2005039537A1 (en) * | 2003-10-22 | 2005-05-06 | Lidds Ab | Composition comprising biodegradable hydrating ceramics for controlled drug delivery |
| DE602005021756D1 (de) | 2004-02-13 | 2010-07-22 | Nod Pharmaceuticals Inc | Partikel mit kern aus calciumphosphat-nanopartikeln, biomolekül und gallensäure, herstellungsverfahren und therapeutische verwendung |
| US8586090B2 (en) * | 2004-10-05 | 2013-11-19 | Albert Einstein College Of Medicine Of Yeshiva University | Melanin nanoshells for protection against radiation and electronic pulses |
| WO2006050368A2 (en) | 2004-11-01 | 2006-05-11 | Biosante Pharmaceuticals, Inc. | Therapeutic calcium phosphate particles iin use for aesthetic or cosmetic medicine, and methods of manufacture and use |
| CA2587556A1 (en) * | 2004-11-16 | 2006-05-26 | 3M Innovative Properties Company | Dental fillers including a phosphorus containing surface treatment, and compositions and methods thereof |
| DE602005023509D1 (de) * | 2004-11-16 | 2010-10-21 | 3M Innovative Properties Co | Dentalfüllstoffe, verfahren, zusammensetzungen mit einem caseinat |
| AU2005306857A1 (en) | 2004-11-16 | 2006-05-26 | 3M Innovative Properties Company | Dental compositions with calcium phosphorus releasing glass |
| ATE493108T1 (de) * | 2004-11-16 | 2011-01-15 | 3M Innovative Properties Co | Dentalfüllstoffe und zusammensetzungen mit phosphatsalzen |
| FR2885525B1 (fr) * | 2005-05-13 | 2009-09-18 | Urodelia Sa | Medicament notamment anti-cancereux, destine a des traitements par immunotherapie, en particulier autologue |
| WO2007059038A2 (en) * | 2005-11-14 | 2007-05-24 | Biomet 3I, Inc. | Deposition of discrete nanoparticles on an implant surface |
| AU2006333978B2 (en) * | 2006-01-06 | 2012-04-19 | Cell-Medicine, Inc. | Immune adjuvant |
| JP4834076B2 (ja) * | 2006-02-23 | 2011-12-07 | 学校法人金沢工業大学 | 超伝導磁気測定装置 |
| EP1996160B8 (en) | 2006-03-14 | 2010-05-12 | Lidds Ab. | Bioresorbable controlled-release composition |
| US8017237B2 (en) * | 2006-06-23 | 2011-09-13 | Abbott Cardiovascular Systems, Inc. | Nanoshells on polymers |
| EP2079401B1 (en) * | 2006-10-24 | 2019-05-22 | Biomet 3i, LLC | Deposition of discrete nanoparticles on a nanostructured surface of an implant |
| US20100260849A1 (en) * | 2007-12-13 | 2010-10-14 | Rusin Richard P | Remineralizing compositions and methods |
| JP5806466B2 (ja) * | 2008-01-28 | 2015-11-10 | バイオメット・3アイ・エルエルシー | 親水性を向上させたインプラント表面 |
| EP2358651A2 (en) | 2008-11-12 | 2011-08-24 | Engqvist, Håkan | Hydraulic cements, methods and products |
| JP2009084292A (ja) * | 2008-11-14 | 2009-04-23 | Cell-Medicine Inc | 免疫アジュバント |
| JP5274214B2 (ja) * | 2008-11-25 | 2013-08-28 | オリンパス株式会社 | 癌細胞抑制シート |
| WO2010068359A1 (en) * | 2008-12-11 | 2010-06-17 | 3M Innovative Properties Company | Surface-treated calcium phosphate particles suitable for oral care and dental compositions |
| JP2012526144A (ja) | 2009-05-06 | 2012-10-25 | ラボラトリー スキン ケア インコーポレイテッド | 活性物質−リン酸カルシウム粒子複合体を含む経皮送達組成物およびその使用方法 |
| JP5633152B2 (ja) * | 2010-02-16 | 2014-12-03 | 東ソー株式会社 | アジュバント |
| RU2562596C2 (ru) | 2010-03-10 | 2015-09-10 | Осс-К Аб | Имплантаты и способы коррекции дефектов ткани |
| US8641418B2 (en) | 2010-03-29 | 2014-02-04 | Biomet 3I, Llc | Titanium nano-scale etching on an implant surface |
| CA2861357C (en) | 2011-01-19 | 2022-08-23 | Laboratory Skin Care, Inc. | Topical minocycline compositions and methods of using the same |
| JP6082901B2 (ja) * | 2011-01-31 | 2017-02-22 | オリンパス株式会社 | ワクチン・アジュバント |
| JP5990752B2 (ja) * | 2011-01-31 | 2016-09-14 | オリンパス株式会社 | 抗体療法の効果増強剤 |
| WO2012105223A1 (ja) * | 2011-01-31 | 2012-08-09 | オリンパス株式会社 | 免疫賦活剤 |
| US9463046B2 (en) | 2011-08-22 | 2016-10-11 | Ossdsign Ab | Implants and methods for using such implants to fill holes in bone tissue |
| US8591645B2 (en) | 2011-09-09 | 2013-11-26 | Ossdsign Ab | Hydraulic cements with optimized grain size distribution, methods, articles and kits |
| US20130066327A1 (en) | 2011-09-09 | 2013-03-14 | Håkan Engqvist | Hydraulic cement compositions with low ph methods, articles and kits |
| JP5999639B2 (ja) * | 2011-11-25 | 2016-09-28 | 国立研究開発法人産業技術総合研究所 | 免疫刺激因子担持微粒子 |
| CN104053445A (zh) * | 2011-12-22 | 2014-09-17 | 奥林巴斯株式会社 | 癌细胞抑制陶瓷和癌细胞抑制陶瓷的制造方法、骨肿瘤的治疗方法、粒径1~10μm的β磷酸三钙多孔体颗粒的应用 |
| EP2828100B1 (en) | 2012-03-20 | 2018-05-16 | Biomet 3i, LLC | Surface treatment for an implant surface |
| EP2931325B1 (en) | 2012-12-14 | 2020-02-19 | OssDsign AB | Cement-forming compositions, monetite cements, implants and methods for correcting bone defects |
| US10076416B2 (en) | 2013-02-12 | 2018-09-18 | Ossdsign Ab | Mosaic implants, kits and methods for correcting bone defects |
| EP2988777B1 (en) * | 2013-04-24 | 2021-02-17 | Medizinische Universität Wien | Novel vaccine formulation for ocular immunization |
| GB201318858D0 (en) * | 2013-10-25 | 2013-12-11 | Glaxosmithkline Biolog Sa | Calcium fluoride compositions |
| GB201318862D0 (en) * | 2013-10-25 | 2013-12-11 | Glaxosmithkline Biolog Sa | Calcium fluoride compositions |
| EP3179961B1 (en) | 2014-08-14 | 2020-12-02 | OssDsign AB | Bone implants for correcting bone defects |
| JPWO2017047095A1 (ja) * | 2015-09-17 | 2018-08-16 | 国立研究開発法人医薬基盤・健康・栄養研究所 | リン酸カルシウムのワクチンアジュバントとしての生理学的特性の最適化 |
| EP3919022B1 (en) | 2019-01-31 | 2025-06-11 | Cell-Medicine, Inc. | Inorganic salt-protein composite medical instrument |
| CU20200032A7 (es) * | 2020-06-09 | 2022-01-13 | Ct Inmunologia Molecular | Composiciones vacunales basadas en nano-partículas de fosfatos de calcio para el tratamiento del cáncer |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2967802A (en) | 1957-12-02 | 1961-01-10 | Diamond Lab | Hydrated calcium phosphate gelantigen composition and method of preparing same |
| FR1604134A (enExample) | 1967-09-26 | 1971-07-12 | ||
| US4016252A (en) | 1972-04-06 | 1977-04-05 | Institut Pasteur | Calcium phosphate gel for adsorbing vaccines |
| FR2181426B1 (enExample) | 1972-04-06 | 1974-12-20 | Pasteur Institut | |
| JPS519714A (enExample) * | 1974-06-04 | 1976-01-26 | Wellcome Found | |
| EP0007895B1 (fr) | 1978-07-19 | 1983-06-22 | Patrick Couvreur | Nanoparticules biodégradables, compositions pharmaceutiques les contenant et procédé pour leur préparation |
| US5085861A (en) * | 1987-03-12 | 1992-02-04 | The Beth Israel Hospital Association | Bioerodable implant composition comprising crosslinked biodegradable polyesters |
| US5324519A (en) * | 1989-07-24 | 1994-06-28 | Atrix Laboratories, Inc. | Biodegradable polymer composition |
| US5290558A (en) * | 1989-09-21 | 1994-03-01 | Osteotech, Inc. | Flowable demineralized bone powder composition and its use in bone repair |
| US5443832A (en) * | 1990-04-16 | 1995-08-22 | Institut Swisse De Recherches Experimentales Sur Le Cancer | Hydroxyapatite-antigen conjugates and methods for generating a poly-Ig immune response |
| US5462751A (en) * | 1990-06-22 | 1995-10-31 | The Regeants Of The University Of California | Biological and pharmaceutical agents having a nanomeric biodegradable core |
| US5782971B1 (en) * | 1991-06-28 | 1999-09-21 | Norian Corp | Calcium phosphate cements comprising amorophous calcium phosphate |
| US5728385A (en) * | 1993-08-12 | 1998-03-17 | Classen Immunotherapies, Inc. | Method and composition for an early vaccine to protect against both common infectious diseases and chronic immune mediated disorders or their sequelae |
| US5508342A (en) * | 1994-02-01 | 1996-04-16 | The United States Of America As Represented By The Secretary Of Commerce | Polymeric amorphous calcium phosphate compositions |
| US5676976A (en) * | 1995-05-19 | 1997-10-14 | Etex Corporation | Synthesis of reactive amorphous calcium phosphates |
| US6287341B1 (en) | 1995-05-19 | 2001-09-11 | Etex Corporation | Orthopedic and dental ceramic implants |
| US6132463A (en) | 1995-05-19 | 2000-10-17 | Etex Corporation | Cell seeding of ceramic compositions |
| US6117456A (en) | 1995-05-19 | 2000-09-12 | Etex Corporation | Methods and products related to the physical conversion of reactive amorphous calcium phosphate |
| US6541037B1 (en) * | 1995-05-19 | 2003-04-01 | Etex Corporation | Delivery vehicle |
| US6027742A (en) | 1995-05-19 | 2000-02-22 | Etex Corporation | Bioresorbable ceramic composites |
| AU734691B2 (en) | 1996-10-16 | 2001-06-21 | Life Science Enterprises, Inc. | Bioceramic compositions |
| US5968253A (en) * | 1998-07-31 | 1999-10-19 | Norian Corporation | Calcium phosphate cements comprising antimicrobial agents |
-
1998
- 1998-09-15 US US09/153,133 patent/US8333996B2/en not_active Expired - Fee Related
-
1999
- 1999-09-14 KR KR1020017003305A patent/KR100756677B1/ko not_active Expired - Fee Related
- 1999-09-14 EP EP99948233A patent/EP1117381A4/en not_active Withdrawn
- 1999-09-14 NZ NZ510198A patent/NZ510198A/en unknown
- 1999-09-14 KR KR1020067021536A patent/KR20060113798A/ko not_active Ceased
- 1999-09-14 JP JP2000569778A patent/JP2002524491A/ja active Pending
- 1999-09-14 CA CA002342207A patent/CA2342207A1/en not_active Abandoned
- 1999-09-14 AU AU61456/99A patent/AU763487B2/en not_active Ceased
- 1999-09-14 WO PCT/US1999/021182 patent/WO2000015194A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| US8333996B2 (en) | 2012-12-18 |
| AU6145699A (en) | 2000-04-03 |
| KR20060113798A (ko) | 2006-11-02 |
| EP1117381A1 (en) | 2001-07-25 |
| US20030082232A1 (en) | 2003-05-01 |
| WO2000015194A1 (en) | 2000-03-23 |
| NZ510198A (en) | 2003-12-19 |
| KR100756677B1 (ko) | 2007-09-10 |
| JP2002524491A (ja) | 2002-08-06 |
| AU763487B2 (en) | 2003-07-24 |
| EP1117381A4 (en) | 2005-02-09 |
| KR20010085796A (ko) | 2001-09-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |