CA2340701A1 - Derives oxindoles en tant qu'agents de liberation de l'hormone de croissance - Google Patents
Derives oxindoles en tant qu'agents de liberation de l'hormone de croissance Download PDFInfo
- Publication number
- CA2340701A1 CA2340701A1 CA002340701A CA2340701A CA2340701A1 CA 2340701 A1 CA2340701 A1 CA 2340701A1 CA 002340701 A CA002340701 A CA 002340701A CA 2340701 A CA2340701 A CA 2340701A CA 2340701 A1 CA2340701 A1 CA 2340701A1
- Authority
- CA
- Canada
- Prior art keywords
- optionally substituted
- growth hormone
- independently hydrogen
- alkyl
- oxindole derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000018997 Growth Hormone Human genes 0.000 title abstract 2
- 108010051696 Growth Hormone Proteins 0.000 title abstract 2
- 239000000122 growth hormone Substances 0.000 title abstract 2
- 125000004095 oxindolyl group Chemical class N1(C(CC2=CC=CC=C12)=O)* 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 5
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- PCKPVGOLPKLUHR-UHFFFAOYSA-N OH-Indolxyl Natural products C1=CC=C2C(O)=CNC2=C1 PCKPVGOLPKLUHR-UHFFFAOYSA-N 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- JYGFTBXVXVMTGB-UHFFFAOYSA-N indolin-2-one Chemical compound C1=CC=C2NC(=O)CC2=C1 JYGFTBXVXVMTGB-UHFFFAOYSA-N 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP23464398 | 1998-08-20 | ||
| JP10/234643 | 1998-08-20 | ||
| PCT/JP1999/004443 WO2000010975A1 (fr) | 1998-08-20 | 1999-08-18 | Derives oxindoles en tant qu'agents de liberation de l'hormone de croissance |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2340701A1 true CA2340701A1 (fr) | 2000-03-02 |
| CA2340701C CA2340701C (fr) | 2009-05-26 |
Family
ID=16974248
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002340701A Expired - Fee Related CA2340701C (fr) | 1998-08-20 | 1999-08-18 | Derives oxindoles en tant qu'agents de liberation de l'hormone de croissance |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6576656B1 (fr) |
| EP (1) | EP1105376B1 (fr) |
| JP (1) | JP4445133B2 (fr) |
| KR (1) | KR100680085B1 (fr) |
| CN (1) | CN1161333C (fr) |
| AT (1) | ATE288895T1 (fr) |
| AU (1) | AU5301199A (fr) |
| CA (1) | CA2340701C (fr) |
| DE (1) | DE69923692T2 (fr) |
| ES (1) | ES2237135T3 (fr) |
| WO (1) | WO2000010975A1 (fr) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60115227T2 (de) | 2000-05-11 | 2006-08-24 | Bristol-Myers Squibb Co. | Tetrahydroisochinolin-analoga als wachstumshormon-sekretagoga |
| WO2002060878A1 (fr) * | 2001-01-30 | 2002-08-08 | Sumitomo Pharmaceuticals Co., Ltd. | Derives de benzimidazolidinone |
| AU2002357692A1 (en) | 2001-11-09 | 2003-05-26 | Bristol-Myers Squibb Company | Tetrahydroisoquinoline analogs as modulators of chemokine receptor activity |
| SE0104341D0 (sv) * | 2001-12-20 | 2001-12-20 | Astrazeneca Ab | New use |
| SE0104340D0 (sv) | 2001-12-20 | 2001-12-20 | Astrazeneca Ab | New compounds |
| AU2002359162A1 (en) * | 2001-12-21 | 2003-07-15 | Astrazeneca Ab | Use of oxindole derivatives in the treatment of dementia related diseases, alzheimer's disease and conditions associated with glycogen synthase kinase-3 |
| TW200301123A (en) * | 2001-12-21 | 2003-07-01 | Astrazeneca Uk Ltd | New use |
| SE0200979D0 (sv) | 2002-03-28 | 2002-03-28 | Astrazeneca Ab | New compounds |
| MXPA05002734A (es) * | 2002-10-24 | 2005-05-23 | Pfizer Prod Inc | Derivados de acilo de 5- (2-(4 -(1, 2-bencisotiazol -3-il) -1-piperazinil) etil)- 6-cloro -1, 3-dihidro -2h- indol -2-ona que presentan actividad neuroleptica. |
| US7476653B2 (en) | 2003-06-18 | 2009-01-13 | Tranzyme Pharma, Inc. | Macrocyclic modulators of the ghrelin receptor |
| US6912165B2 (en) * | 2003-08-22 | 2005-06-28 | International Business Machines Corporation | Method for transparent updates of output driver impedance |
| WO2005035498A1 (fr) * | 2003-10-08 | 2005-04-21 | Dainippon Sumitomo Pharma Co., Ltd. | Utilisation d'un compose bicyclique azote comme agent de regulation alimentaire |
| JP2008510706A (ja) | 2004-08-18 | 2008-04-10 | エリクシアー ファーマシューティカルズ， インコーポレイテッド | 成長ホルモン分泌促進物質 |
| WO2007032371A1 (fr) | 2005-09-14 | 2007-03-22 | Dainippon Sumitomo Pharma Co., Ltd. | Dérivé d'oxindole en tant qu'agent de contrôle d'alimentation |
| CU23558A1 (es) | 2006-02-28 | 2010-07-20 | Ct Ingenieria Genetica Biotech | Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento |
| BRPI0807046A2 (pt) | 2007-02-09 | 2015-05-26 | Tranzyme Pharma Inc | Composto, composição farmacêutica, métodos de tratar um distúrbio, uma doença cardiovascular e um paciente que sofre de motilidade gastrointestinal reduzida ou disfuncional e, kit. |
| FR2920023B1 (fr) * | 2007-08-16 | 2013-02-08 | Sanofi Aventis | Derives de l'indol-2-one disubstitues en 3, leur preparation et leur application en therapeutique |
| MX2010013920A (es) * | 2008-06-26 | 2011-02-21 | Amgen Inc | Alcoholes alquinilicos como inhibidores de cinasas. |
| FR2941947B1 (fr) * | 2009-02-12 | 2011-03-25 | Sanofi Aventis | Derives de 3-benzofuranyl-indol-2-one subtitues en 3, leur preparation et leur application en therapeutique |
| FR2941946B1 (fr) * | 2009-02-12 | 2011-03-25 | Sanofi Aventis | Derives de 3-benzofuranyl-indol-2-one-3-acetamidopiperazines substitues, leur preparation et leur application en therapeutique |
| EP2246326A1 (fr) * | 2009-05-02 | 2010-11-03 | Bayer CropScience AG | Procédé de fabrication d'oxindoles et d'anilines ortho-substitués et leur utilisation en tant que produits intermédiaires pour synthèses |
| EP2770997B1 (fr) | 2011-10-28 | 2016-09-14 | Vanderbilt University | Analogues substitues 2-(4-heterocyclylbenzyle)isoindoline-1-un employes comme modulateurs allosteriques positifs du recepteur m1 acetylcholine muscarinique |
| US9073935B2 (en) | 2011-11-11 | 2015-07-07 | Vanderbilt University | Substituted benzylspiroindolin-2-one analogs as positive allosteric modulators of the muscarinic acetylcholine receptor M1 |
| US9029563B2 (en) | 2012-01-06 | 2015-05-12 | Vanderbilt University | Substituted 1-benzylindolin-2-one analogs as positive allosteric modulators of muscarinic acetylcholine M1 receptors |
| US8697888B2 (en) * | 2012-01-06 | 2014-04-15 | Vanderbilt University | Substituted (1-(methylsulfonyl)azetidin-3-yl)(heterocycloalkyl)methanone analogs as antagonists of muscarinic acetylcholine M1 receptors |
| US9012445B2 (en) | 2012-01-12 | 2015-04-21 | Vanderbilt University | Substituted 4-(1H-pyrazol-4-yl)benzyl analogues as positive allosteric modulators of mAChR M1 receptors |
| CN110354265A (zh) | 2012-10-24 | 2019-10-22 | 第一三共株式会社 | 用于肌萎缩性侧索硬化的治疗剂 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB125671A (en) | 1917-07-03 | 1919-05-01 | James Rossiter Hoyle | Improvements in or relating to Armour Piercing Projectiles. |
| US3441570A (en) * | 1966-01-20 | 1969-04-29 | Parke Davis & Co | 3-tertiary aminoalkylamino-3-phenyl oxindole compounds |
| US3891644A (en) * | 1971-01-11 | 1975-06-24 | Wyeth John & Brother Ltd | 10,10-Disubstituted-2,3,4,10-tetrahydro-and 1,2,3,4,10a-hexahydropyrimidol {8 1,2-a{9 indole derivatives |
| GB1450137A (en) | 1973-12-20 | 1976-09-22 | Wyeth John & Brother Ltd | Indole derivatives |
| US5283241A (en) * | 1992-08-28 | 1994-02-01 | Merck & Co., Inc. | Benzo-fused lactams promote release of growth hormone |
-
1999
- 1999-08-18 WO PCT/JP1999/004443 patent/WO2000010975A1/fr active IP Right Grant
- 1999-08-18 DE DE69923692T patent/DE69923692T2/de not_active Expired - Lifetime
- 1999-08-18 US US09/763,241 patent/US6576656B1/en not_active Expired - Fee Related
- 1999-08-18 AU AU53011/99A patent/AU5301199A/en not_active Abandoned
- 1999-08-18 KR KR1020017002123A patent/KR100680085B1/ko not_active IP Right Cessation
- 1999-08-18 CN CNB998098574A patent/CN1161333C/zh not_active Expired - Fee Related
- 1999-08-18 EP EP99938515A patent/EP1105376B1/fr not_active Expired - Lifetime
- 1999-08-18 JP JP2000566249A patent/JP4445133B2/ja not_active Expired - Fee Related
- 1999-08-18 AT AT99938515T patent/ATE288895T1/de not_active IP Right Cessation
- 1999-08-18 ES ES99938515T patent/ES2237135T3/es not_active Expired - Lifetime
- 1999-08-18 CA CA002340701A patent/CA2340701C/fr not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| KR20010085413A (ko) | 2001-09-07 |
| EP1105376A1 (fr) | 2001-06-13 |
| CN1313853A (zh) | 2001-09-19 |
| ATE288895T1 (de) | 2005-02-15 |
| DE69923692T2 (de) | 2006-03-23 |
| ES2237135T3 (es) | 2005-07-16 |
| US6576656B1 (en) | 2003-06-10 |
| AU5301199A (en) | 2000-03-14 |
| CA2340701C (fr) | 2009-05-26 |
| EP1105376B1 (fr) | 2005-02-09 |
| KR100680085B1 (ko) | 2007-02-28 |
| CN1161333C (zh) | 2004-08-11 |
| DE69923692D1 (de) | 2005-03-17 |
| JP2002523400A (ja) | 2002-07-30 |
| JP4445133B2 (ja) | 2010-04-07 |
| WO2000010975A1 (fr) | 2000-03-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20150818 |