CA2338384A1 - Peptide fragments of cholera toxin b or enterotoxin b as vaccine adjuvants - Google Patents
Peptide fragments of cholera toxin b or enterotoxin b as vaccine adjuvants Download PDFInfo
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- CA2338384A1 CA2338384A1 CA002338384A CA2338384A CA2338384A1 CA 2338384 A1 CA2338384 A1 CA 2338384A1 CA 002338384 A CA002338384 A CA 002338384A CA 2338384 A CA2338384 A CA 2338384A CA 2338384 A1 CA2338384 A1 CA 2338384A1
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- NCEXYHBECQHGNR-QZQOTICOSA-N sulfasalazine Chemical compound C1=C(O)C(C(=O)O)=CC(\N=N\C=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-QZQOTICOSA-N 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 229940126577 synthetic vaccine Drugs 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- 238000012085 transcriptional profiling Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 239000013603 viral vector Substances 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 238000003158 yeast two-hybrid assay Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/28—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9819484.8 | 1998-09-07 | ||
| GBGB9819484.8A GB9819484D0 (en) | 1998-09-07 | 1998-09-07 | Therapeutic agents |
| PCT/GB1999/002970 WO2000014114A1 (en) | 1998-09-07 | 1999-09-07 | Peptide fragments of cholera toxin b or enterotoxin b as vaccine adjuvants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2338384A1 true CA2338384A1 (en) | 2000-03-16 |
Family
ID=10838466
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002338384A Abandoned CA2338384A1 (en) | 1998-09-07 | 1999-09-07 | Peptide fragments of cholera toxin b or enterotoxin b as vaccine adjuvants |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP1109828A1 (cs) |
| JP (1) | JP2002524469A (cs) |
| KR (1) | KR20010044842A (cs) |
| CN (1) | CN1317013A (cs) |
| AU (1) | AU772015B2 (cs) |
| BR (1) | BR9913501A (cs) |
| CA (1) | CA2338384A1 (cs) |
| CZ (1) | CZ2001839A3 (cs) |
| EA (1) | EA200100314A1 (cs) |
| GB (2) | GB9819484D0 (cs) |
| HU (1) | HUP0104090A2 (cs) |
| IL (1) | IL141695A0 (cs) |
| IS (1) | IS5829A (cs) |
| MX (1) | MXPA01002387A (cs) |
| NO (1) | NO20011075L (cs) |
| NZ (1) | NZ509631A (cs) |
| PL (1) | PL346549A1 (cs) |
| WO (1) | WO2000014114A1 (cs) |
| ZA (1) | ZA200100758B (cs) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010036917A1 (en) | 1995-07-05 | 2001-11-01 | Williams Neil Andrew | Therapeutic agents |
| GB9800487D0 (en) * | 1998-01-09 | 1998-03-04 | Oratol Limited | Therapies |
| GB0115382D0 (en) | 2001-06-22 | 2001-08-15 | Univ Bristol | Mutant |
| WO2004047793A1 (en) | 2002-11-26 | 2004-06-10 | Alk-Abelló A/S | Pharmaceutical allergen product |
| CN104402974B (zh) * | 2014-12-10 | 2017-11-14 | 重庆医科大学 | 一种具有粘膜免疫佐剂活性的多肽及其在制备粘膜免疫佐剂中的用途 |
| WO2024121125A1 (en) * | 2022-12-06 | 2024-06-13 | Bactolife A/S | Single-domain antibodies to reduce the risk of cholera infection |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2527445A1 (fr) * | 1982-05-26 | 1983-12-02 | Centre Nat Rech Scient | Medicaments contenant au moins une sequence de la sous-unite b1 de la toxine cholerique |
| IL69558A (en) * | 1983-08-23 | 1988-06-30 | Yeda Res & Dev | Synthetic cholera vaccine |
| ZA839512B (en) * | 1983-12-12 | 1984-08-29 | Scripps Clinic Res | Synthetic heat-stable enterotoxin polypeptide of escherichia coli and multimers thereof |
| FR2636842B1 (fr) * | 1988-09-27 | 1994-06-10 | Liege Universite Etat | Proteine de fusion d'une sequence derivee de la sous-unite b de la toxine cholerique et d'un antigene heterologue doue de proprietes immunogenes, compositions de vaccins les contenant et acides nucleiques recombinants contenant une sequence de nucleotides codant pour ladite proteine de fusion |
| EP0738325A1 (en) * | 1994-01-27 | 1996-10-23 | GX BioSystems A/S | Receptor specific bacterial adhesins and their use |
| IL109519A (en) * | 1994-05-03 | 1999-03-12 | Yeda Res & Dev | Vaccines for oral immunization against infecting agents |
| US6019982A (en) * | 1994-08-26 | 2000-02-01 | The Administrators Of The Tulane Educational Fund | Mutant enterotoxin effective as a non-toxic oral adjuvant |
-
1998
- 1998-09-07 GB GBGB9819484.8A patent/GB9819484D0/en not_active Ceased
-
1999
- 1999-09-07 CN CN99810666A patent/CN1317013A/zh active Pending
- 1999-09-07 IL IL14169599A patent/IL141695A0/xx unknown
- 1999-09-07 EP EP99944696A patent/EP1109828A1/en not_active Withdrawn
- 1999-09-07 CA CA002338384A patent/CA2338384A1/en not_active Abandoned
- 1999-09-07 BR BR9913501-9A patent/BR9913501A/pt not_active IP Right Cessation
- 1999-09-07 JP JP2000568871A patent/JP2002524469A/ja not_active Withdrawn
- 1999-09-07 EA EA200100314A patent/EA200100314A1/ru unknown
- 1999-09-07 GB GB0107375A patent/GB2357507A/en not_active Withdrawn
- 1999-09-07 HU HU0104090A patent/HUP0104090A2/hu unknown
- 1999-09-07 WO PCT/GB1999/002970 patent/WO2000014114A1/en not_active Application Discontinuation
- 1999-09-07 MX MXPA01002387A patent/MXPA01002387A/es unknown
- 1999-09-07 PL PL99346549A patent/PL346549A1/xx not_active Application Discontinuation
- 1999-09-07 NZ NZ509631A patent/NZ509631A/en unknown
- 1999-09-07 AU AU57516/99A patent/AU772015B2/en not_active Ceased
- 1999-09-07 CZ CZ2001839A patent/CZ2001839A3/cs unknown
- 1999-09-07 KR KR1020017002217A patent/KR20010044842A/ko not_active Application Discontinuation
-
2001
- 2001-01-26 IS IS5829A patent/IS5829A/is unknown
- 2001-01-26 ZA ZA200100758A patent/ZA200100758B/en unknown
- 2001-03-02 NO NO20011075A patent/NO20011075L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB2357507A (en) | 2001-06-27 |
| PL346549A1 (en) | 2002-02-11 |
| IL141695A0 (en) | 2002-03-10 |
| AU772015B2 (en) | 2004-04-08 |
| NO20011075L (no) | 2001-05-07 |
| GB9819484D0 (en) | 1998-10-28 |
| KR20010044842A (ko) | 2001-06-05 |
| GB0107375D0 (en) | 2001-05-16 |
| WO2000014114A1 (en) | 2000-03-16 |
| AU5751699A (en) | 2000-03-27 |
| MXPA01002387A (es) | 2002-05-08 |
| EP1109828A1 (en) | 2001-06-27 |
| NZ509631A (en) | 2003-11-28 |
| BR9913501A (pt) | 2001-06-05 |
| NO20011075D0 (no) | 2001-03-02 |
| JP2002524469A (ja) | 2002-08-06 |
| CN1317013A (zh) | 2001-10-10 |
| EA200100314A1 (ru) | 2001-10-22 |
| CZ2001839A3 (cs) | 2001-08-15 |
| ZA200100758B (en) | 2001-07-16 |
| HUP0104090A2 (hu) | 2002-01-28 |
| IS5829A (is) | 2001-03-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |