CA2337256A1 - Composition therapeutique a base d'isoflavonoides destinee a etre utilisee dans le traitement des tumeurs par des agents cytotoxiques - Google Patents

Composition therapeutique a base d'isoflavonoides destinee a etre utilisee dans le traitement des tumeurs par des agents cytotoxiques Download PDF

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Publication number
CA2337256A1
CA2337256A1 CA002337256A CA2337256A CA2337256A1 CA 2337256 A1 CA2337256 A1 CA 2337256A1 CA 002337256 A CA002337256 A CA 002337256A CA 2337256 A CA2337256 A CA 2337256A CA 2337256 A1 CA2337256 A1 CA 2337256A1
Authority
CA
Canada
Prior art keywords
day
infusion
isoflavonoid
days
bolus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002337256A
Other languages
English (en)
Inventor
Robert Kiss
Armand Frydman
Francis Darro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cephalon France SAS
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2337256A1 publication Critical patent/CA2337256A1/fr
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

La présente invention concerne une composition ayant une activité sur la prolifération de cellules clonogènes dans des tumeurs et qui comprend une quantité thérapeutiquement efficace d'un isoflavonoïde ou d'un composé analogue de type chromone, notamment d'un composé choisi parmi les composés de formule (I) dans laquelle: R¿1?, R¿2?, R¿3? et R¿4?, R¿5? et R¿6? sont tels que définis à la reventication (2). Cette composition est destinée à être utilisée dans le traitement des tumeurs par des agents cytotoxiques.
CA002337256A 1998-07-15 1999-07-13 Composition therapeutique a base d'isoflavonoides destinee a etre utilisee dans le traitement des tumeurs par des agents cytotoxiques Abandoned CA2337256A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR98/09059 1998-07-15
FR9809059A FR2781154B1 (fr) 1998-07-15 1998-07-15 Composition therapeutique a base d'isoflavonoides destinee a etre utilisee dans le traitement des tumeurs par des agents cytotoxiques
PCT/FR1999/001715 WO2000003707A1 (fr) 1998-07-15 1999-07-13 Composition therapeutique a base d'isoflavonoïdes destinee a etre utilisee dans le traitement des tumeurs par des agents cytotoxiques

Publications (1)

Publication Number Publication Date
CA2337256A1 true CA2337256A1 (fr) 2000-01-27

Family

ID=9528649

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002337256A Abandoned CA2337256A1 (fr) 1998-07-15 1999-07-13 Composition therapeutique a base d'isoflavonoides destinee a etre utilisee dans le traitement des tumeurs par des agents cytotoxiques

Country Status (11)

Country Link
EP (1) EP1096929A1 (fr)
JP (1) JP2002520357A (fr)
KR (1) KR20020006510A (fr)
CN (1) CN1139383C (fr)
AU (1) AU761417B2 (fr)
BR (1) BR9912817A (fr)
CA (1) CA2337256A1 (fr)
EA (1) EA200100141A1 (fr)
FR (1) FR2781154B1 (fr)
IL (1) IL140580A0 (fr)
WO (1) WO2000003707A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7906554B2 (en) 2002-10-02 2011-03-15 Novogen Research Pty Ltd Combination chemotherapy compositions and methods

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6146668A (en) 1997-04-28 2000-11-14 Novogen, Inc. Preparation of isoflavones from legumes
AUPP260798A0 (en) 1998-03-26 1998-04-23 Novogen Research Pty Ltd Treatment of medical related conditions with isoflavone containing extracts of clover
AUPQ266199A0 (en) * 1999-09-06 1999-09-30 Novogen Research Pty Ltd Compositions and therapeutic methods involving isoflavones and analogues thereof
PL205635B1 (pl) * 2001-04-09 2010-05-31 Inst Farmaceutyczny Nowe pochodne genisteiny i zawierające je środki farmaceutyczne
AU2003217982A1 (en) * 2002-03-06 2003-09-22 The Medical Research And Education Trust Botanical extract compositions with anti-cancer or phytoestrogenic activity comprising wogonin, isoliquiritigenin and/or coumestrol
DE10337863A1 (de) 2003-08-18 2005-03-17 Merck Patent Gmbh Verwendung von Chromen-4-on-Derivaten
CA2590048C (fr) 2007-05-23 2013-07-16 Institut National De La Recherche Scientifique Analogues de nucleoside de cytosine et isoflavones et leurs utilisations
CN106265669A (zh) * 2016-08-04 2017-01-04 大连理工大学 大豆苷元与10‑羟基喜树碱的药物组合及其应用
CN113842387A (zh) * 2021-11-19 2021-12-28 大连理工大学盘锦产业技术研究院 10-羟基喜树碱与鹰嘴豆芽素a的药物组合物及其应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0617304B2 (ja) * 1982-09-09 1994-03-09 理化学研究所 制癌剤
US5506211A (en) * 1994-05-09 1996-04-09 The Uab Research Foundation Genistein for use in inhibiting osteroclasts
US5824702A (en) * 1996-06-07 1998-10-20 Mount Sinai School Of Medicine Of The City University Of New York Genistein as a preventive against ultraviolet induced skin photodamage and cancer
AUPO203996A0 (en) * 1996-08-30 1996-09-26 Novogen Research Pty Ltd Therapeutic uses
JP2829387B2 (ja) * 1996-09-13 1998-11-25 農林水産省四国農業試験場長 脂肪細胞における脂肪分解促進用組成物
GB9621757D0 (en) * 1996-10-18 1996-12-11 Ciba Geigy Ag Phenyl-substituted bicyclic heterocyclyl derivatives and their use
US5733926A (en) * 1996-12-13 1998-03-31 Gorbach; Sherwood L. Isoflavonoids for treatment and prevention of alzheimer dementia and reduced cognitive functions

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7906554B2 (en) 2002-10-02 2011-03-15 Novogen Research Pty Ltd Combination chemotherapy compositions and methods

Also Published As

Publication number Publication date
AU761417B2 (en) 2003-06-05
FR2781154B1 (fr) 2001-09-07
CN1312712A (zh) 2001-09-12
WO2000003707A1 (fr) 2000-01-27
CN1139383C (zh) 2004-02-25
KR20020006510A (ko) 2002-01-19
EP1096929A1 (fr) 2001-05-09
EA200100141A1 (ru) 2001-06-25
IL140580A0 (en) 2002-02-10
FR2781154A1 (fr) 2000-01-21
BR9912817A (pt) 2001-05-08
JP2002520357A (ja) 2002-07-09
AU4628299A (en) 2000-02-07

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Legal Events

Date Code Title Description
FZDE Discontinued