CA2335685C - Benflumetol derivatives, intermediates thereof and their use against parasitical protozoa and trematodes - Google Patents
Benflumetol derivatives, intermediates thereof and their use against parasitical protozoa and trematodes Download PDFInfo
- Publication number
- CA2335685C CA2335685C CA002335685A CA2335685A CA2335685C CA 2335685 C CA2335685 C CA 2335685C CA 002335685 A CA002335685 A CA 002335685A CA 2335685 A CA2335685 A CA 2335685A CA 2335685 C CA2335685 C CA 2335685C
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- Prior art keywords
- formula
- compound
- salt
- hydroxy
- acid
- Prior art date
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- 241000869417 Trematodes Species 0.000 title claims abstract description 9
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- 239000000543 intermediate Substances 0.000 title description 6
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- 125000001424 substituent group Chemical group 0.000 claims abstract description 23
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- 238000000034 method Methods 0.000 claims description 51
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 18
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- 125000006239 protecting group Chemical group 0.000 claims description 16
- 125000003282 alkyl amino group Chemical group 0.000 claims description 15
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- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
- C07C215/38—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings with rings other than six-membered aromatic rings being part of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/08—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
- C07C2603/18—Fluorenes; Hydrogenated fluorenes
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1351/98 | 1998-06-25 | ||
| CH135198 | 1998-06-25 | ||
| PCT/EP1999/004355 WO1999067197A1 (en) | 1998-06-25 | 1999-06-23 | Benflumetol derivatives, intermediates thereof and their use against parasitical protozoa and trematodes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2335685A1 CA2335685A1 (en) | 1999-12-29 |
| CA2335685C true CA2335685C (en) | 2009-08-11 |
Family
ID=4208448
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002335685A Expired - Lifetime CA2335685C (en) | 1998-06-25 | 1999-06-23 | Benflumetol derivatives, intermediates thereof and their use against parasitical protozoa and trematodes |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6329552B2 (https=) |
| EP (1) | EP1089961B1 (https=) |
| JP (1) | JP4355450B2 (https=) |
| CN (1) | CN1183097C (https=) |
| AT (1) | ATE259346T1 (https=) |
| AU (1) | AU4776399A (https=) |
| BR (1) | BRPI9912208B8 (https=) |
| CA (1) | CA2335685C (https=) |
| CO (1) | CO5040050A1 (https=) |
| ES (1) | ES2216528T3 (https=) |
| ID (1) | ID27500A (https=) |
| MY (1) | MY117662A (https=) |
| PE (1) | PE20000703A1 (https=) |
| PT (1) | PT1089961E (https=) |
| TW (2) | TW200528419A (https=) |
| WO (1) | WO1999067197A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104093689A (zh) * | 2012-01-31 | 2014-10-08 | 剑桥显示技术有限公司 | 聚合物 |
| CN111320547B (zh) * | 2020-04-03 | 2022-05-20 | 南京昊绿生物科技有限公司 | 一种苯芴醇-d9的合成方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1029680C (zh) * | 1988-11-10 | 1995-09-06 | 军事医学科学院微生物流行病研究所 | 抗疟新药苯芴醇的合成新工艺 |
| CN1058717A (zh) * | 1990-08-08 | 1992-02-19 | 中国人民解放军军事医学科学院微生物流行病研究所 | 抗疟新药—复方蒿甲醚及其制备方法 |
-
1999
- 1999-06-11 CO CO99036913A patent/CO5040050A1/es unknown
- 1999-06-23 ES ES99931151T patent/ES2216528T3/es not_active Expired - Lifetime
- 1999-06-23 CA CA002335685A patent/CA2335685C/en not_active Expired - Lifetime
- 1999-06-23 MY MYPI99002590A patent/MY117662A/en unknown
- 1999-06-23 AU AU47763/99A patent/AU4776399A/en not_active Abandoned
- 1999-06-23 PE PE1999000560A patent/PE20000703A1/es not_active IP Right Cessation
- 1999-06-23 PT PT99931151T patent/PT1089961E/pt unknown
- 1999-06-23 EP EP99931151A patent/EP1089961B1/en not_active Expired - Lifetime
- 1999-06-23 BR BRPI9912208A patent/BRPI9912208B8/pt not_active IP Right Cessation
- 1999-06-23 ID IDW20002736A patent/ID27500A/id unknown
- 1999-06-23 AT AT99931151T patent/ATE259346T1/de active
- 1999-06-23 JP JP2000555853A patent/JP4355450B2/ja not_active Expired - Lifetime
- 1999-06-23 CN CNB998096180A patent/CN1183097C/zh not_active Expired - Lifetime
- 1999-06-23 WO PCT/EP1999/004355 patent/WO1999067197A1/en not_active Ceased
- 1999-07-13 TW TW094115936A patent/TW200528419A/zh unknown
- 1999-07-13 TW TW088110752A patent/TWI250141B/zh not_active IP Right Cessation
-
2000
- 2000-12-22 US US09/746,041 patent/US6329552B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| HK1035712A1 (en) | 2001-12-07 |
| ID27500A (id) | 2001-04-12 |
| MY117662A (en) | 2004-07-31 |
| BRPI9912208B8 (pt) | 2021-05-25 |
| EP1089961A1 (en) | 2001-04-11 |
| CN1312794A (zh) | 2001-09-12 |
| PE20000703A1 (es) | 2000-08-23 |
| PT1089961E (pt) | 2004-06-30 |
| EP1089961B1 (en) | 2004-02-11 |
| WO1999067197A1 (en) | 1999-12-29 |
| JP2002518467A (ja) | 2002-06-25 |
| TW200528419A (en) | 2005-09-01 |
| CA2335685A1 (en) | 1999-12-29 |
| AU4776399A (en) | 2000-01-10 |
| CO5040050A1 (es) | 2001-05-29 |
| BR9912208A (pt) | 2001-04-10 |
| CN1183097C (zh) | 2005-01-05 |
| JP4355450B2 (ja) | 2009-11-04 |
| ATE259346T1 (de) | 2004-02-15 |
| TWI250141B (en) | 2006-03-01 |
| US6329552B2 (en) | 2001-12-11 |
| ES2216528T3 (es) | 2004-10-16 |
| BRPI9912208B1 (pt) | 2016-04-19 |
| US20010014699A1 (en) | 2001-08-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20190625 |