CA2335685C - Derives de benflumetol, leurs intermediaires et leur utilisation contre des protozoaires et trematodes parasitaires - Google Patents

Derives de benflumetol, leurs intermediaires et leur utilisation contre des protozoaires et trematodes parasitaires Download PDF

Info

Publication number
CA2335685C
CA2335685C CA002335685A CA2335685A CA2335685C CA 2335685 C CA2335685 C CA 2335685C CA 002335685 A CA002335685 A CA 002335685A CA 2335685 A CA2335685 A CA 2335685A CA 2335685 C CA2335685 C CA 2335685C
Authority
CA
Canada
Prior art keywords
formula
compound
salt
hydroxy
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002335685A
Other languages
English (en)
Other versions
CA2335685A1 (fr
Inventor
Thomas Allmendinger
Walther Helmut Wernsdorfer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of CA2335685A1 publication Critical patent/CA2335685A1/fr
Application granted granted Critical
Publication of CA2335685C publication Critical patent/CA2335685C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C07C215/38—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings with rings other than six-membered aromatic rings being part of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/08—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

L'invention concerne un composé de la formule (I) dans laquelle R représente un alkyle non substitué ou substitué par un ou plusieurs substituants polaires ou un alcényle non substitué ou substitué par un ou plusieurs substituants polaires, et X représente un aryle ; ou des sels de ce composé. Les composés selon l'invention sont efficaces contre les protozoaires et trématodes.
CA002335685A 1998-06-25 1999-06-23 Derives de benflumetol, leurs intermediaires et leur utilisation contre des protozoaires et trematodes parasitaires Expired - Lifetime CA2335685C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH135198 1998-06-25
CH1351/98 1998-06-25
PCT/EP1999/004355 WO1999067197A1 (fr) 1998-06-25 1999-06-23 Derives de benflumetol, leurs intermediaires et leur utilisation contre des protozoaires et trematodes parasitaires

Publications (2)

Publication Number Publication Date
CA2335685A1 CA2335685A1 (fr) 1999-12-29
CA2335685C true CA2335685C (fr) 2009-08-11

Family

ID=4208448

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002335685A Expired - Lifetime CA2335685C (fr) 1998-06-25 1999-06-23 Derives de benflumetol, leurs intermediaires et leur utilisation contre des protozoaires et trematodes parasitaires

Country Status (17)

Country Link
US (1) US6329552B2 (fr)
EP (1) EP1089961B1 (fr)
JP (1) JP4355450B2 (fr)
CN (1) CN1183097C (fr)
AT (1) ATE259346T1 (fr)
AU (1) AU4776399A (fr)
BR (1) BRPI9912208B8 (fr)
CA (1) CA2335685C (fr)
CO (1) CO5040050A1 (fr)
ES (1) ES2216528T3 (fr)
HK (1) HK1035712A1 (fr)
ID (1) ID27500A (fr)
MY (1) MY117662A (fr)
PE (1) PE20000703A1 (fr)
PT (1) PT1089961E (fr)
TW (2) TW200528419A (fr)
WO (1) WO1999067197A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI574987B (zh) * 2012-01-31 2017-03-21 劍橋顯示科技有限公司 聚合物
JP7375343B2 (ja) 2019-06-25 2023-11-08 味の素株式会社 樹脂組成物
CN111320547B (zh) * 2020-04-03 2022-05-20 南京昊绿生物科技有限公司 一种苯芴醇-d9的合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1029680C (zh) * 1988-11-10 1995-09-06 军事医学科学院微生物流行病研究所 抗疟新药苯芴醇的合成新工艺
CN1058717A (zh) * 1990-08-08 1992-02-19 中国人民解放军军事医学科学院微生物流行病研究所 抗疟新药—复方蒿甲醚及其制备方法

Also Published As

Publication number Publication date
BR9912208A (pt) 2001-04-10
US20010014699A1 (en) 2001-08-16
CO5040050A1 (es) 2001-05-29
EP1089961B1 (fr) 2004-02-11
HK1035712A1 (en) 2001-12-07
TWI250141B (en) 2006-03-01
US6329552B2 (en) 2001-12-11
PT1089961E (pt) 2004-06-30
AU4776399A (en) 2000-01-10
EP1089961A1 (fr) 2001-04-11
CA2335685A1 (fr) 1999-12-29
MY117662A (en) 2004-07-31
BRPI9912208B1 (pt) 2016-04-19
PE20000703A1 (es) 2000-08-23
CN1312794A (zh) 2001-09-12
WO1999067197A1 (fr) 1999-12-29
ES2216528T3 (es) 2004-10-16
TW200528419A (en) 2005-09-01
JP2002518467A (ja) 2002-06-25
CN1183097C (zh) 2005-01-05
JP4355450B2 (ja) 2009-11-04
ATE259346T1 (de) 2004-02-15
ID27500A (id) 2001-04-12
BRPI9912208B8 (pt) 2021-05-25

Similar Documents

Publication Publication Date Title
US8394794B2 (en) Therapeutic compounds
AU608580B2 (en) 1,4-disubstituted piperazine compounds, their production and use
US6255317B1 (en) Cholesterol biosynthesis inhibitors
NZ548375A (en) Azabenzofuran substituted thioureas as inhibitors of viral replication
US5346897A (en) Agents for potentiating the effects of antitumor agents and combating multiple drug resistance
EP0350012A2 (fr) Composition antivirale
RU2086548C1 (ru) Дигидропиридиновые производные или их фармацевтически приемлемые соли и фармацевтическая композиция на их основе
EP0228959B1 (fr) Composés aminostyryl, leur utilisation dans une composition leukotriène-antagoniste et procédé les utilisant pour s'opposer à l'SRS
EP2184073A1 (fr) Agent thérapeutique pour le cancer avec une résistance à l'inhibiteur de la protéase
CA2335685C (fr) Derives de benflumetol, leurs intermediaires et leur utilisation contre des protozoaires et trematodes parasitaires
CA2234342A1 (fr) Remede pour la pancreatite
EP0237191A1 (fr) Alkoxy-3 amino-2 propylamines utiles comme agents cardiovasculaires
US4476128A (en) 2-Substituted thiazolyl-piperazine compounds, process for preparation thereof and utilizations thereof _
MXPA01000230A (en) Benflumetol derivatives, intermediates thereof and their use against parasitical protozoa and trematodes
EP0027679B1 (fr) Composés substitués du 5 ((-7-chloro-4-quinoléinyl)amino)-3-(aminométhyl)-(1,1'-biphényl)-2-ol; procédé pour leur préparation; et compositions pharmaceutiques les contenant
US8022080B2 (en) Small molecules with antiprotozoal activity
US8653095B2 (en) Small molecules with antimalarial activity
US3973017A (en) Imidazothiazines, derivatives and analogues thereof
RU2240313C2 (ru) Лекарственные средства для лечения злокачественных опухолей
US11618738B2 (en) Compound and application thereof in treating inflammation or inflammation-related diseases
US6242466B1 (en) Substituted phenylamidines
US3503980A (en) Tetrahydroazacycloalkano(1,2-a) pyridazines
US4606860A (en) Rhodanines useful as a therapeutic agent for diabetic complications
US8859578B2 (en) Natural product derivatives with antiprotozoal activity
WO2023122756A2 (fr) Inhibiteurs ulk1 et ulk2

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20190625