CA2335566C - Effervescent drug delivery system for oral administration - Google Patents

Effervescent drug delivery system for oral administration Download PDF

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Publication number
CA2335566C
CA2335566C CA2335566A CA2335566A CA2335566C CA 2335566 C CA2335566 C CA 2335566C CA 2335566 A CA2335566 A CA 2335566A CA 2335566 A CA2335566 A CA 2335566A CA 2335566 C CA2335566 C CA 2335566C
Authority
CA
Canada
Prior art keywords
drug
dosage form
effervescent
amount
penetration enhancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2335566A
Other languages
English (en)
French (fr)
Other versions
CA2335566A1 (en
Inventor
S. Indiran Pather
Joseph R. R0Binson
Jonathan D. Eichman
Rajendra K. Khankari
John Hontz
Sangeeta V. Gupte
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cima Labs Inc
Original Assignee
Cima Labs Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cima Labs Inc filed Critical Cima Labs Inc
Publication of CA2335566A1 publication Critical patent/CA2335566A1/en
Application granted granted Critical
Publication of CA2335566C publication Critical patent/CA2335566C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0007—Effervescent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2335566A 1999-04-29 2000-04-25 Effervescent drug delivery system for oral administration Expired - Fee Related CA2335566C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/302,105 1999-04-29
US09/302,105 US6350470B1 (en) 1998-04-29 1999-04-29 Effervescent drug delivery system for oral administration
PCT/US2000/011053 WO2000066089A1 (en) 1999-04-29 2000-04-25 Effervescent drug delivery system for oral administration

Publications (2)

Publication Number Publication Date
CA2335566A1 CA2335566A1 (en) 2000-11-09
CA2335566C true CA2335566C (en) 2010-07-06

Family

ID=23166279

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2335566A Expired - Fee Related CA2335566C (en) 1999-04-29 2000-04-25 Effervescent drug delivery system for oral administration

Country Status (6)

Country Link
US (5) US6350470B1 (https=)
EP (1) EP1091732A4 (https=)
JP (1) JP2002543109A (https=)
AU (1) AU4488700A (https=)
CA (1) CA2335566C (https=)
WO (1) WO2000066089A1 (https=)

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CA2335566A1 (en) 2000-11-09
US20020076439A1 (en) 2002-06-20
US20030133976A1 (en) 2003-07-17
US20020071809A1 (en) 2002-06-13
US6509036B2 (en) 2003-01-21
US6641838B2 (en) 2003-11-04
US6391335B1 (en) 2002-05-21
EP1091732A4 (en) 2006-01-18
EP1091732A1 (en) 2001-04-18
AU4488700A (en) 2000-11-17
JP2002543109A (ja) 2002-12-17
US6350470B1 (en) 2002-02-26
US6764696B2 (en) 2004-07-20
WO2000066089A1 (en) 2000-11-09

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