JP5112876B2 - 還元型グルタチオン経口投与のためのリポソーム処方物 - Google Patents
還元型グルタチオン経口投与のためのリポソーム処方物 Download PDFInfo
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- JP5112876B2 JP5112876B2 JP2007539376A JP2007539376A JP5112876B2 JP 5112876 B2 JP5112876 B2 JP 5112876B2 JP 2007539376 A JP2007539376 A JP 2007539376A JP 2007539376 A JP2007539376 A JP 2007539376A JP 5112876 B2 JP5112876 B2 JP 5112876B2
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- glutathione
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Description
尚、本出願は、米国出願番号60/522,785、(題名:(還元型)グルタチオンの経口投与のためのリポソーム処方物、出願日:2004年11月5日)の優先権を主張する。本出願は、仮出願番号60/597,041(題名:(還元型)グルタチオンの経口投与のためのリボソーム処方物)、および、仮出願番号60/554,996(題名:(還元型)グルタチオンの経口投与および/または、グルタチオン欠乏およびメチオニン再メチル化経路欠陥による疾患へのリポソーム処方物の使用、出願日:2005年5月25日)の優先権を主張する。本出願はこれら出願の一部継続出願である。
・嚢胞性線維症
・肝臓疾患
・パーキンソン病
・アルツハイマー病
・心臓麻痺および心臓発作
・糖尿病
・ウイルス性疾患
・核、生物学的および生化学的損傷に起因する活性酸素損傷
・細菌感染による活性酸素損傷
・予防接種後の免疫系調節
融合:リポソーム膜と細胞膜の併合により、リポソーム含有物が細胞内へ輸送される。
パーキンソン病(PD)は、神経―運動経路に関する症状で、4つの初期症状によって特徴付けられる。
・手、腕、足、顎、および顔の振戦、もしくは、震え。
・肢および幹の硬直、もしくは、こわばり。
・動作緩慢、もしくは、動作が遅くなること
・体位の不安定性、もしくは、平衡および協調障害
リポソームグルタチオンドリンク又はスプレー(2500mg/1オンス)
リポソームグルタチオンドリンク又はスプレー(2500mg/1オンス)、又はカプセル封入に適した形態、又はゲル
別個のビーカに、水、グリセリン及びグルタチオンを含む水混合物が混合されて、50℃まで加熱された。
EDTA(1000mg/1オンス)を含むリポソームグルタチオンドリンク又はスプレー(1000mg/1オンス)
嚢胞性線維症におけるリポソームグルタチオン
4歳児(MF)は嚢胞性繊維症と診断され、汗の塩素濃度が高い等の特徴的な所見が確認されている。彼女は、抗生物質治療が必要となるような呼吸器系感染症に頻繁にかかり、また、慢性的に咳をする。彼女の母親は、彼女が活発に遊ばなくなった、また身体的活動が制限されているとの見解を示した。MFの赤血球のグルタチオンレベルは、2004年に136と確認された。(正常領域は200〜400マイクロモル/Lである)
深刻な慢性肺疾患と慢性副鼻腔うっ血の症状を示すCF患者(23歳)について、彼女の肺機能は2年間非常に低いレベルであり、変化がない。
ベースラインRBC GSHは低い。
ベースラインRBC GSHは46マイクロモル/Lで低い。治療して3週間後、RBC GSHは246マイクロモル/Lであった。RBC GSHの正常範囲は、200〜400マイクロモル/Lである。
18ヶ月の女児(GF)は、胃腸に嚢胞性線維症の兆候が見られた。最初の12ヶ月の彼女の成長パターンは正常で、彼女の体重も50パーセンタイルであった。最初の診断の時、彼女の体重は25パーセンタイルまで減少した。グルタチオンの血中レベルは正常であった。女児は1日2回、100mg/30ポンドの用量でリポソームグルタチオンを摂取して処置された。
1オンスは小さじ5.56杯である。小さじ1杯分の経口リポソーム還元型グルタチオンはおよそ440mgGSHを含む。
パーキンソン病に対する本発明の好適な応用は、最初にグルタチオン治療に対する患者の反応を確認することである。この治療とは、グルタチオン1500mgの静脈内注射を用いるものである。1回1500mgのグルタチオン静脈投与を、12〜24時間おきに合計3回行う。そして、患者の反応を確認する。このグルタチオンの使用により、好ましい兆候(患者のパーキンソン病の症状の改善)が確認された場合は、本発明(リポソームグルタチオン)を経口投与して、パーキンソン病の症状の改善を図ることができる。
カルビドパ/レボドパ(各10/100含有錠剤:カルビドパ10mgとレボドパ100mg、各25/100含有錠剤:カルビドパ25mgとレボドパ100mg、各25/250含有錠剤:カルビドパ25mgとレボドパ250mg、放出抑制錠剤:カルビドパ50mgとレボドパ200mg)
67歳の女性(PP)は、手が震える症状を示し、これはパーキンソン病の症状と一致する。彼女は、この震えにより、ボタンを留める動作やサインする動作が困難である。彼女は、リポソーム還元型グルタチオンを経口投与され、この投与は、600mgを1週間に2回行うというものであった。このリポソーム還元型グルタチオンの投与をして3週間後、PPの震えは顕著に減少したことが確認された。この震えの減少により、PPは、ボタンを容易に且つ早く留めることが可能となり、サインをすることもできるようになった。
最初の治療は、好ましくは、小さじ1.5杯量のリポソームグルタチオンを投与することで、このリポソームグルタチオン量には、約660mgのグルタチオンを含む。前記投与を、1日2回、2週間行う。この投与の期間の間で、臨床的な改善が確認された場合は、患者のよい反応が維持できる程度まで用量を減らして、投与を継続的に行ってもよい。
最初の用量は、1オンス(=2500mg)である。全投与或いは4回投与を、12時間おきに行う。患者の反応を確認して、臨床的に反応が得られる程度の用量で投与を継続する。以下は、用量を決定するための体重の指標である。表中、患者の体重と治療に対する反応により日用量を決定し、還元型グルタチオンを「GSH」という。
Claims (1)
- 71.9%w/wの脱イオン水、
15.00%w/wのグリセリン、
2.50%w/wのポリソルベート−20、
1.50%w/wのレシチン、
0.50%w/wのシトラス・シード抽出物、
0.10%w/wのソルビン酸カリウム、および
8.50%w/wの還元型グルタチオン、
を含む、嚢胞性線維症又はパーキンソン病を処置するための、ドリンク又はスプレーとしてのみの経口投与のためのリポソームグルタチオン。
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US52278504P | 2004-11-07 | 2004-11-07 | |
US60/522,785 | 2004-11-07 | ||
US59499605P | 2005-05-25 | 2005-05-25 | |
US60/594,996 | 2005-05-25 | ||
US59704105P | 2005-11-06 | 2005-11-06 | |
US60/597,041 | 2005-11-06 | ||
PCT/US2005/040308 WO2006060120A2 (en) | 2004-11-07 | 2005-11-07 | Liposomal formulation for oral administration of glutathione (reduced) |
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JP2012005488A Division JP5571706B2 (ja) | 2004-11-07 | 2012-01-13 | 還元型グルタチオン経口投与のためのリポソーム処方物 |
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JP2008518976A JP2008518976A (ja) | 2008-06-05 |
JP2008518976A5 JP2008518976A5 (ja) | 2012-09-13 |
JP5112876B2 true JP5112876B2 (ja) | 2013-01-09 |
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JP2012005488A Expired - Fee Related JP5571706B2 (ja) | 2004-11-07 | 2012-01-13 | 還元型グルタチオン経口投与のためのリポソーム処方物 |
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JP (2) | JP5112876B2 (ja) |
CA (1) | CA2628777C (ja) |
ES (1) | ES2395555T3 (ja) |
IL (1) | IL182950A (ja) |
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EP1868572A4 (en) * | 2005-03-29 | 2011-03-09 | F Timothy Guilford | ADMINISTRATION OF GLUTATHION (REDUCED) ON THE INTRAVENOUS WAY OR CAPSULATED IN A LIPOSOME FOR THE TREATMENT OF TNF ALPHA EFFECTS AND FLUID VIRAL SYMPTOMS |
US20120264810A1 (en) * | 2009-09-22 | 2012-10-18 | The University Of British Columbia | Compositions and methods for enhancing cellular uptake and intracellular delivery of lipid particles |
WO2011082283A2 (en) * | 2009-12-30 | 2011-07-07 | Guilford F Timothy | Management of myoclonus with oral liposomal reduced glutathione |
US10016389B2 (en) | 2011-01-05 | 2018-07-10 | Livon Laboratories | Method of making liposomes, liposome compositions made by the methods, and methods of using the same |
US20150030668A1 (en) * | 2012-01-05 | 2015-01-29 | Frederick Timothy Guilford | Liposomally encapsulated reduced glutathione for management of cancer, including with other pharmaceutical compositions |
WO2013103840A1 (en) * | 2012-01-05 | 2013-07-11 | Guilford Frederick Timothy | Anti-cancer composition and method utilizing 3-bp and liposomal reduced glutathione |
WO2014070769A1 (en) | 2012-10-29 | 2014-05-08 | The University Of North Carolina At Chapel Hill | Methods and compositions for treating mucosal tissue disorders |
EP2956153A4 (en) * | 2013-02-15 | 2017-03-22 | Your Energy Systems, LLC | Treatment of evolving bacterial resistance diseases including klebsiella pneumoniae with liposomally formulated glutathione |
TWI589308B (zh) * | 2014-03-25 | 2017-07-01 | 林信湧 | 一種用於治療帕金森氏症之吸入式醫藥組成物及其備製方法 |
AU2017362500A1 (en) | 2016-11-17 | 2019-06-13 | Renovion, Inc. | Treatment of Respiratory Tract Diseases and Infections with Ascorbic Acid Compositions |
CN111615395A (zh) | 2017-11-17 | 2020-09-01 | 莱诺翁股份有限公司 | 稳定的抗坏血酸组合物及其使用方法 |
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FR2609393A1 (fr) * | 1988-02-23 | 1988-07-15 | Serobiologiques Lab Sa | Composition notamment utile comme matiere de base pour la preparation de compositions pharmaceutiques, notamment dermatologiques et/ou cosmetiques comprenant une substance azotee, notamment aminoacides, oligo- ou polypeptides, proteines, et leurs derives, et composition pharmaceutique ou cosmetique ainsi preparee. |
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2005
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- 2005-11-07 CA CA2628777A patent/CA2628777C/en active Active
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ES2395555T3 (es) | 2013-02-13 |
CA2628777A1 (en) | 2006-06-08 |
IL182950A0 (en) | 2007-08-19 |
EP1817006B1 (en) | 2012-09-05 |
WO2006060120A2 (en) | 2006-06-08 |
EP1817006A2 (en) | 2007-08-15 |
CA2628777C (en) | 2016-09-13 |
JP2008518976A (ja) | 2008-06-05 |
PL1817006T3 (pl) | 2013-03-29 |
WO2006060120A3 (en) | 2006-09-14 |
JP2012102138A (ja) | 2012-05-31 |
JP5571706B2 (ja) | 2014-08-13 |
EP1817006A4 (en) | 2009-12-02 |
IL182950A (en) | 2013-10-31 |
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