CA2331299A1 - Guanidines et diaminonitroethenes substituees, preparation et applications - Google Patents
Guanidines et diaminonitroethenes substituees, preparation et applications Download PDFInfo
- Publication number
- CA2331299A1 CA2331299A1 CA002331299A CA2331299A CA2331299A1 CA 2331299 A1 CA2331299 A1 CA 2331299A1 CA 002331299 A CA002331299 A CA 002331299A CA 2331299 A CA2331299 A CA 2331299A CA 2331299 A1 CA2331299 A1 CA 2331299A1
- Authority
- CA
- Canada
- Prior art keywords
- cyano
- trifluoromethyl
- guanidine
- bis
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 0 *c1cc(*)c(*)c(NC(N*)=*)c1 Chemical compound *c1cc(*)c(*)c(NC(N*)=*)c1 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C211/44—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
- C07C211/52—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/28—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to cyano groups, e.g. cyanoguanidines, dicyandiamides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Cette invention, qui a trait à des dérivés de guanidine et de diaminonitroéthène correspondant à la formule (I), X, R?1¿, R?2¿, R?3¿ et R?4¿ étant définis dans le descriptif, concerne également des compositions à base de ces substances ainsi que des procédés de préparation des composés décrits. Ces composés s'avèrent des plus utiles en matière de traitement de maladies du système nerveux central, du système cardio-vasculaire, du système pulmonaire, de l'appareil digestif et du système endocrinien.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK63498 | 1998-05-11 | ||
DK0634/98 | 1998-05-11 | ||
PCT/DK1999/000251 WO1999058497A1 (fr) | 1998-05-11 | 1999-05-06 | Guanidines et diaminonitroethenes substituees, preparation et applications |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2331299A1 true CA2331299A1 (fr) | 1999-11-18 |
Family
ID=8095813
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002331299A Abandoned CA2331299A1 (fr) | 1998-05-11 | 1999-05-06 | Guanidines et diaminonitroethenes substituees, preparation et applications |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1077933A1 (fr) |
JP (1) | JP2002514621A (fr) |
AU (1) | AU3595799A (fr) |
CA (1) | CA2331299A1 (fr) |
WO (1) | WO1999058497A1 (fr) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6268284B1 (en) | 1998-10-07 | 2001-07-31 | Tokyo Electron Limited | In situ titanium aluminide deposit in high aspect ratio features |
MXPA03001535A (es) * | 2000-08-21 | 2004-12-13 | Pacific Corp | Derivados de tiourea novedosos y las composiciones farmaceuticas que contienen los mismos. |
CA2571717A1 (fr) * | 2004-06-23 | 2006-01-05 | Josette-Nicole Mahy Gehenne | Composes destines au traitement de l'inflammation du systeme nerveux central |
PT3461834T (pt) | 2013-03-13 | 2021-09-10 | Sage Therapeutics Inc | Esteroides neuroativos |
CN108135911B (zh) | 2015-07-06 | 2021-06-25 | 萨奇治疗股份有限公司 | 氧甾醇及其使用方法 |
ES2921010T3 (es) | 2016-04-01 | 2022-08-16 | Sage Therapeutics Inc | Oxisteroles y procedimientos de uso de los mismos |
WO2017193046A1 (fr) | 2016-05-06 | 2017-11-09 | Sage Therapeutics, Inc. | Oxystérols et méthodes d'utilisation associées |
PL3481846T3 (pl) | 2016-07-07 | 2021-12-20 | Sage Therapeutics, Inc. | 11-podstawione 24-hydroksysterole do stosowania w leczeniu stanów związanych z NMDA |
US11149056B2 (en) | 2016-09-30 | 2021-10-19 | Sage Therapeutics, Inc. | C7 substituted oxysterols and methods of use thereof |
JP2019532079A (ja) | 2016-10-18 | 2019-11-07 | セージ セラピューティクス, インコーポレイテッド | オキシステロールおよびその使用方法 |
US11149054B2 (en) | 2016-10-18 | 2021-10-19 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3232462A1 (de) * | 1982-09-01 | 1984-03-01 | Bayer Ag, 5090 Leverkusen | 2-nitro-1,1-ethendiamine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
DE3783529T2 (de) * | 1986-07-23 | 1993-05-13 | Hitachi Chemical Co Ltd | Optisches aufzeichnungsmedium. |
EP0310545A3 (fr) * | 1987-09-02 | 1989-07-26 | Ciba-Geigy Ag | Cyanoguanidines comme durcisseur de résines epoxydes |
JP2749639B2 (ja) * | 1989-06-28 | 1998-05-13 | 鐘紡株式会社 | シアノグアニジン誘導体 |
JPH0558985A (ja) * | 1991-08-29 | 1993-03-09 | Kanebo Ltd | シアノグアニジン誘導体の製造法 |
DK41193D0 (da) * | 1993-04-07 | 1993-04-07 | Neurosearch As | Ionkanalaabnere |
JP3270789B2 (ja) * | 1994-01-31 | 2002-04-02 | カネボウ株式会社 | 養毛剤 |
-
1999
- 1999-05-06 WO PCT/DK1999/000251 patent/WO1999058497A1/fr not_active Application Discontinuation
- 1999-05-06 CA CA002331299A patent/CA2331299A1/fr not_active Abandoned
- 1999-05-06 JP JP2000548301A patent/JP2002514621A/ja active Pending
- 1999-05-06 AU AU35957/99A patent/AU3595799A/en not_active Abandoned
- 1999-05-06 EP EP99917806A patent/EP1077933A1/fr not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
AU3595799A (en) | 1999-11-29 |
JP2002514621A (ja) | 2002-05-21 |
EP1077933A1 (fr) | 2001-02-28 |
WO1999058497A1 (fr) | 1999-11-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |