CA2329704A1 - Substituted beta-amino acid inhibitors of methionine aminopeptidase-2 - Google Patents

Substituted beta-amino acid inhibitors of methionine aminopeptidase-2 Download PDF

Info

Publication number
CA2329704A1
CA2329704A1 CA002329704A CA2329704A CA2329704A1 CA 2329704 A1 CA2329704 A1 CA 2329704A1 CA 002329704 A CA002329704 A CA 002329704A CA 2329704 A CA2329704 A CA 2329704A CA 2329704 A1 CA2329704 A1 CA 2329704A1
Authority
CA
Canada
Prior art keywords
amino
cyclohexyl
hydroxy
butanamide
hydroxybutanamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002329704A
Other languages
English (en)
French (fr)
Inventor
Richard A. Craig
Jack Henkin
Megumi Kawai
Linda Lijewski Lynch
Jyoti Patel
George S. Sheppard
Jieyi Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority claimed from PCT/US1999/009641 external-priority patent/WO1999057098A2/en
Publication of CA2329704A1 publication Critical patent/CA2329704A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
CA002329704A 1998-05-01 1999-04-30 Substituted beta-amino acid inhibitors of methionine aminopeptidase-2 Abandoned CA2329704A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7171498A 1998-05-01 1998-05-01
US09/071,714 1998-05-01
PCT/US1999/009641 WO1999057098A2 (en) 1998-05-01 1999-04-30 Substituted beta-amino acid inhibitors of methionine aminopeptidase-2

Publications (1)

Publication Number Publication Date
CA2329704A1 true CA2329704A1 (en) 1999-11-11

Family

ID=22103106

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002329704A Abandoned CA2329704A1 (en) 1998-05-01 1999-04-30 Substituted beta-amino acid inhibitors of methionine aminopeptidase-2

Country Status (9)

Country Link
EP (1) EP1073633A2 (ko)
JP (1) JP2002513781A (ko)
KR (1) KR20010043198A (ko)
CN (1) CN1308608A (ko)
AU (1) AU3877899A (ko)
CA (1) CA2329704A1 (ko)
CO (1) CO5021134A1 (ko)
IL (1) IL139139A0 (ko)
PL (1) PL346444A1 (ko)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100357283C (zh) * 2002-04-02 2007-12-26 中国科学院上海药物研究所 一类甲硫氨酰氨肽酶抑制剂
CN1688557A (zh) * 2002-10-09 2005-10-26 辉瑞产品公司 用于治疗神经变性疾病的噻唑化合物
CA2513684A1 (en) * 2003-01-31 2004-08-19 Merck & Co., Inc. 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
FR2858617A1 (fr) * 2003-08-06 2005-02-11 Inst Nat Sante Rech Med Derives de 4',4'-dithiobis-(3-aminobutane-1-sulfonate-1- sulfonates) nouveaux et compositions les contenant
CN102241678B (zh) * 2011-04-26 2014-10-29 辽宁利锋科技开发有限公司 含有脂环结构化合物的抗肿瘤作用与应用
CN104230935A (zh) * 2011-04-26 2014-12-24 辽宁利锋科技开发有限公司 含有脂环结构化合物的抗肿瘤作用与应用
CA3008960A1 (en) * 2016-01-11 2017-07-20 Syndevrx, Inc. Treatment for tumors driven by metabolic dysfunction
CN115124449B (zh) * 2022-05-24 2024-02-02 上海英诺富成生物科技有限公司 一种吲哚化合物及制备方法与应用

Also Published As

Publication number Publication date
AU3877899A (en) 1999-11-23
JP2002513781A (ja) 2002-05-14
KR20010043198A (ko) 2001-05-25
PL346444A1 (en) 2002-02-11
CO5021134A1 (es) 2001-03-27
CN1308608A (zh) 2001-08-15
IL139139A0 (en) 2001-11-25
EP1073633A2 (en) 2001-02-07

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Legal Events

Date Code Title Description
FZDE Discontinued