CA2329704A1 - Inhibiteurs beta-amino-acide substitues de la methionine aminopeptidas e-2 - Google Patents

Inhibiteurs beta-amino-acide substitues de la methionine aminopeptidas e-2 Download PDF

Info

Publication number
CA2329704A1
CA2329704A1 CA002329704A CA2329704A CA2329704A1 CA 2329704 A1 CA2329704 A1 CA 2329704A1 CA 002329704 A CA002329704 A CA 002329704A CA 2329704 A CA2329704 A CA 2329704A CA 2329704 A1 CA2329704 A1 CA 2329704A1
Authority
CA
Canada
Prior art keywords
amino
cyclohexyl
hydroxy
butanamide
hydroxybutanamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002329704A
Other languages
English (en)
Inventor
Richard A. Craig
Jack Henkin
Megumi Kawai
Linda Lijewski Lynch
Jyoti Patel
George S. Sheppard
Jieyi Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority claimed from PCT/US1999/009641 external-priority patent/WO1999057098A2/fr
Publication of CA2329704A1 publication Critical patent/CA2329704A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

L'invention concerne une catégorie de .beta.-amino-acides substitués, lesquels constituent des inhibiteurs puissants de la méthionine aminopeptidase de type 2 (MetAP2) et sont donc utiles pour inhiber l'angiogénie et des pathologies qui dépendent de l'angiogénie pour leur développement, comme la rétinopathie diabétique, la croissance tumorale et des états inflammatoires. L'invention concerne également des préparations pharmaceutiques contenant ces composés, ainsi que des procédés d'inhibition de la méthionine aminopeptidase-2 et de l'angiogénie.
CA002329704A 1998-05-01 1999-04-30 Inhibiteurs beta-amino-acide substitues de la methionine aminopeptidas e-2 Abandoned CA2329704A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7171498A 1998-05-01 1998-05-01
US09/071,714 1998-05-01
PCT/US1999/009641 WO1999057098A2 (fr) 1998-05-01 1999-04-30 INHIBITEURS β-AMINO-ACIDE SUBSTITUES DE LA METHIONINE AMINOPEPTIDASE-2

Publications (1)

Publication Number Publication Date
CA2329704A1 true CA2329704A1 (fr) 1999-11-11

Family

ID=22103106

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002329704A Abandoned CA2329704A1 (fr) 1998-05-01 1999-04-30 Inhibiteurs beta-amino-acide substitues de la methionine aminopeptidas e-2

Country Status (9)

Country Link
EP (1) EP1073633A2 (fr)
JP (1) JP2002513781A (fr)
KR (1) KR20010043198A (fr)
CN (1) CN1308608A (fr)
AU (1) AU3877899A (fr)
CA (1) CA2329704A1 (fr)
CO (1) CO5021134A1 (fr)
IL (1) IL139139A0 (fr)
PL (1) PL346444A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100357283C (zh) * 2002-04-02 2007-12-26 中国科学院上海药物研究所 一类甲硫氨酰氨肽酶抑制剂
EP1551815A1 (fr) * 2002-10-09 2005-07-13 Pfizer Products Inc. Composes thiazole utiles pour le traitement des maladies neurodegeneratives
JP2006516573A (ja) * 2003-01-31 2006-07-06 メルク　エンド　カムパニー　インコーポレーテッド 糖尿病の治療および予防のためのジペプチジルペプチダーゼ阻害薬としての３−アミノ−４−フェニルブタン酸誘導体
FR2858617A1 (fr) * 2003-08-06 2005-02-11 Inst Nat Sante Rech Med Derives de 4',4'-dithiobis-(3-aminobutane-1-sulfonate-1- sulfonates) nouveaux et compositions les contenant
CN102241678B (zh) * 2011-04-26 2014-10-29 辽宁利锋科技开发有限公司 含有脂环结构化合物的抗肿瘤作用与应用
CN104230935A (zh) * 2011-04-26 2014-12-24 辽宁利锋科技开发有限公司 含有脂环结构化合物的抗肿瘤作用与应用
WO2017123603A1 (fr) * 2016-01-11 2017-07-20 Syndevrx, Inc. Traitement de tumeurs induites par un dysfonctionnement métabolique
CN115124449B (zh) * 2022-05-24 2024-02-02 上海英诺富成生物科技有限公司 一种吲哚化合物及制备方法与应用

Also Published As

Publication number Publication date
EP1073633A2 (fr) 2001-02-07
AU3877899A (en) 1999-11-23
JP2002513781A (ja) 2002-05-14
PL346444A1 (en) 2002-02-11
IL139139A0 (en) 2001-11-25
CO5021134A1 (es) 2001-03-27
KR20010043198A (ko) 2001-05-25
CN1308608A (zh) 2001-08-15

Similar Documents

Publication Publication Date Title
US6242494B1 (en) Substituted β-amino acid inhibitors of methionine aminopeptidase-2
EP0445796B1 (fr) Dérivés de l'acide acétique contenant des liaisons peptidiques
US5514716A (en) Hydroxamic acid and carboxylic acid derivatives, process for their preparation and use thereof
US7166590B2 (en) Amino acid derivatives
AU617429B2 (en) Amino acid derivatives
US20020103192A1 (en) Inhibitors of histone deacetylase
EP0309766B1 (fr) Dérivés N-acylés d'aminoacides et leur utilisation
US11530182B2 (en) YAP1 inhibitors that target the interaction of YAP1 with Oct4
EP1080069B1 (fr) Derives d'acide anthrenilique utilises comme inhibiteurs de cgmp-phosphodiesterase
US20050282872A1 (en) Novel thyroid receptor ligands and method II
HU206192B (en) Process for producing benzoic acid and phenylacetic acid derivatives and pharmaceutical compositions comprising such active ingredient
SK94196A3 (en) Metalloproteinase inhibitors, pharmaceutical compositions containing them, manufacturing process thereof and their use
AU3241000A (en) Novel sulfonamide compounds and uses thereof
EP0579650A1 (fr) Nouveaux composes
KR20010023001A (ko) 관절염 치료용 아그레카나제 및 기질 메탈로프로테나제의 신규 억제제
WO2005056529A1 (fr) Inhibiteurs des proteases a cysteine du type cathepsine
SK65097A3 (en) Metalloproteinase inhibitors, manufacturing process thereof and pharmaceutical composition containing the same
CA2329704A1 (fr) Inhibiteurs beta-amino-acide substitues de la methionine aminopeptidas e-2
WO1999057098A2 (fr) INHIBITEURS β-AMINO-ACIDE SUBSTITUES DE LA METHIONINE AMINOPEPTIDASE-2
CA2535359A1 (fr) Inhibiteurs de cathepsine et de cysteine protease
JP2628820B2 (ja) アミノ酸誘導体及びその医薬品としての利用
EP0262053A2 (fr) Nouveaux dérivés d'amino-acides, leur procédé de préparation et compositions pharmaceutiques les contenant
DE60106740T2 (de) Hydrazid und alkoxyamid angiogeneseinhibitoren
MXPA00010791A (en) Substituted beta-amino acid inhibitors of methionine aminopeptidase-2
CZ20003967A3 (cs) Substituované beta-aminokyselinové inhibitory methioninaminopeptidasy-2

Legal Events

Date Code Title Description
FZDE Discontinued