CA2328612A1 - Lymphocytes t actives, antigenes specifiques du systeme nerveux et leur utilisation - Google Patents
Lymphocytes t actives, antigenes specifiques du systeme nerveux et leur utilisation Download PDFInfo
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- CA2328612A1 CA2328612A1 CA002328612A CA2328612A CA2328612A1 CA 2328612 A1 CA2328612 A1 CA 2328612A1 CA 002328612 A CA002328612 A CA 002328612A CA 2328612 A CA2328612 A CA 2328612A CA 2328612 A1 CA2328612 A1 CA 2328612A1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0007—Nervous system antigens; Prions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/46432—Nervous system antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Psychiatry (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Marine Sciences & Fisheries (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
L'invention concerne des compositions et des procédés destinés à traiter des lésions ou des maladies des systèmes nerveux central et périphérique. Dans un mode de réalisation, le traitement est effectué au moyen de lymphocytes T activés qui reconnaissent un antigène du système nerveux ou un peptide dérivé à partir de celui-là ou un dérivé de ce dernier, et ce afin de favoriser la régénération des nerfs ou d'empêcher ou d'inhiber la dégénérescence neuronale à l'intérieur du système nerveux. Le traitement consiste à administrer un antigène spécifique du système nerveux ou un peptide dérivé à partir de celui-ci, ou une séquence de nucléotides codant pour cet antigène ou peptide; à favoriser la régénération des nerfs ou à empêcher ou inhiber la dégénérescence neuronale à l'intérieur du système nerveux, que ce soit dans le système nerveux central ou dans celui périphérique. Les lymphocytes T activés spécifiques du système nerveux peuvent être administrés isolément ou en combinaison avec un peptide ou un antigène spécifique du système nerveux dérivé de ceux-ci, ou avec un dérivé de ces derniers ou une séquence de nucléotides codant pour cet antigène ou peptide, ou avec n'importe quelle combinaison de ces éléments.
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL12455098A IL124550A0 (en) | 1997-07-21 | 1998-05-19 | Compositions comprising activated t-cells or t-cell activating agents and their use |
| IL124550 | 1998-05-19 | ||
| USPCT/US98/14715 | 1998-07-21 | ||
| PCT/US1998/014715 WO1999034827A1 (fr) | 1998-07-21 | 1998-07-21 | Lymphocytes actives et leurs utilisations |
| US09/218,277 US20030108528A1 (en) | 1998-05-19 | 1998-12-22 | Activated t-cells, nervous system-specific antigens and their uses |
| US09/218,277 | 1998-12-22 | ||
| PCT/US1999/010953 WO1999060021A2 (fr) | 1998-05-19 | 1999-05-19 | Lymphocytes t actives, antigenes specifiques du systeme nerveux et leur utilisation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2328612A1 true CA2328612A1 (fr) | 1999-11-25 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002328612A Abandoned CA2328612A1 (fr) | 1998-05-19 | 1999-05-19 | Lymphocytes t actives, antigenes specifiques du systeme nerveux et leur utilisation |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1080110A2 (fr) |
| JP (1) | JP2003532618A (fr) |
| CA (1) | CA2328612A1 (fr) |
| WO (1) | WO1999060021A2 (fr) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0866805A1 (fr) | 1995-12-12 | 1998-09-30 | Karolinska Innovations AB | PEPTIDE FIXANT LA SEQUENCE KLVFF DE L'AMYLOIDE $g(b) |
| US6905686B1 (en) | 1997-12-02 | 2005-06-14 | Neuralab Limited | Active immunization for treatment of alzheimer's disease |
| US6750324B1 (en) | 1997-12-02 | 2004-06-15 | Neuralab Limited | Humanized and chimeric N-terminal amyloid beta-antibodies |
| US7790856B2 (en) | 1998-04-07 | 2010-09-07 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
| US6787523B1 (en) | 1997-12-02 | 2004-09-07 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
| US20080050367A1 (en) | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
| TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| US20020072493A1 (en) * | 1998-05-19 | 2002-06-13 | Yeda Research And Development Co. Ltd. | Activated T cells, nervous system-specific antigens and their uses |
| US20030147882A1 (en) | 1998-05-21 | 2003-08-07 | Alan Solomon | Methods for amyloid removal using anti-amyloid antibodies |
| US7060670B1 (en) | 1999-05-05 | 2006-06-13 | Neurochem (International) Limited | Stereoselective antifibrillogenic peptides and peptidomimetics thereof |
| US6787637B1 (en) | 1999-05-28 | 2004-09-07 | Neuralab Limited | N-Terminal amyloid-β antibodies |
| UA81216C2 (en) | 1999-06-01 | 2007-12-25 | Prevention and treatment of amyloid disease | |
| US7700751B2 (en) | 2000-12-06 | 2010-04-20 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize β-amyloid peptide |
| SI1429800T1 (sl) | 2001-12-06 | 2009-08-31 | Yeda Res & Dev | Cepivo in njegova uporaba za zdravljenje amiotrofiäśne lateralne skleroze |
| MY139983A (en) | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
| PE20050627A1 (es) | 2003-05-30 | 2005-08-10 | Wyeth Corp | Anticuerpos humanizados que reconocen el peptido beta amiloideo |
| JP2008523815A (ja) | 2004-12-15 | 2008-07-10 | エラン ファーマ インターナショナル リミテッド | 認知の改善における使用のためのヒト化アミロイドβ抗体 |
| US8784810B2 (en) | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
| US8003097B2 (en) | 2007-04-18 | 2011-08-23 | Janssen Alzheimer Immunotherapy | Treatment of cerebral amyloid angiopathy |
| EP2182983B1 (fr) | 2007-07-27 | 2014-05-21 | Janssen Alzheimer Immunotherapy | Traitement de maladies amyloïdogéniques avec anti-abeta anticorps humanise |
| JO3076B1 (ar) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
| US9067981B1 (en) | 2008-10-30 | 2015-06-30 | Janssen Sciences Ireland Uc | Hybrid amyloid-beta antibodies |
| US20150238582A1 (en) | 2012-09-10 | 2015-08-27 | Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science | Individualized immunomodulation therapy for neurodegenerative disorders, cns injury and age-related dementia |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991001746A1 (fr) * | 1989-08-09 | 1991-02-21 | The Children's Medical Center Corporation | Recepteur de thy-1 et son utilisation pour regenerer les prolongements de cellules nerveuses |
| BR9306272A (pt) * | 1992-04-09 | 1998-06-23 | Autoimmune Inc | Peptídeo e composiçao farmacêutica |
| GB9403250D0 (en) * | 1994-02-21 | 1994-04-13 | Univ Mcgill | Therapeutic use of myelin-associated glycoprotein (mag) |
| JPH09511990A (ja) * | 1994-04-08 | 1997-12-02 | ブリガム アンド ウィミンズ ホスピタル | 経口寛容および／またはＴｈ２増強サイトカインを用いた自己免疫疾患の治療 |
| CZ122697A3 (en) * | 1994-10-25 | 1997-09-17 | Immulogic Pharma Corp | Preparations and methods of treating disseminated sclerosis |
| WO1997001352A1 (fr) * | 1995-06-27 | 1997-01-16 | Research Foundation Of Cuny, Hunter College | Compositions et procedes utilisant la glycoproteine associee a la myeline (mag) et ses inhibiteurs |
| US5800812A (en) * | 1995-09-15 | 1998-09-01 | Yeda Research And Development Co. Ltd. | Methods of use of mononuclear phagocytes to promote axonal regeneration |
| SE505316C2 (sv) * | 1995-10-17 | 1997-08-04 | Kenneth G Haglid | Användning av proteinet S-100b för framställning av läkemedel för nervceller |
| AU5671196A (en) * | 1996-03-28 | 1997-10-17 | Immulogic Pharmaceutical Corporation | Myelin oligodendrocyte glycoprotein peptides and uses thereof |
| SE9703287D0 (sv) * | 1997-09-11 | 1997-09-11 | Astra Ab | Peptides |
| WO1999053945A1 (fr) * | 1998-04-16 | 1999-10-28 | Samuel David | Molecules inhibant la croissance neuronale ou leurs derives utilises pour immuniser des mammiferes et ainsi favoriser la regeneration de l'axone |
-
1999
- 1999-05-19 JP JP2000549639A patent/JP2003532618A/ja not_active Abandoned
- 1999-05-19 WO PCT/US1999/010953 patent/WO1999060021A2/fr active IP Right Grant
- 1999-05-19 EP EP99923190A patent/EP1080110A2/fr not_active Withdrawn
- 1999-05-19 CA CA002328612A patent/CA2328612A1/fr not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999060021A2 (fr) | 1999-11-25 |
| JP2003532618A (ja) | 2003-11-05 |
| WO1999060021A3 (fr) | 2000-06-15 |
| EP1080110A2 (fr) | 2001-03-07 |
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Legal Events
| Date | Code | Title | Description |
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| EEER | Examination request | ||
| FZDE | Discontinued |