CA2328140C - Method of inhibiting osteoclast activity - Google Patents
Method of inhibiting osteoclast activity Download PDFInfo
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- CA2328140C CA2328140C CA2328140A CA2328140A CA2328140C CA 2328140 C CA2328140 C CA 2328140C CA 2328140 A CA2328140 A CA 2328140A CA 2328140 A CA2328140 A CA 2328140A CA 2328140 C CA2328140 C CA 2328140C
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)
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Landscapes
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Compounds Of Unknown Constitution (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
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| US60/085,487 | 1998-05-14 | ||
| US11083698P | 1998-12-03 | 1998-12-03 | |
| US60/110,836 | 1998-12-03 | ||
| PCT/US1999/010588 WO1999058674A2 (en) | 1998-05-14 | 1999-05-13 | Method of inhibiting osteoclast activity |
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| CA2328140A1 CA2328140A1 (en) | 1999-11-18 |
| CA2328140C true CA2328140C (en) | 2012-03-13 |
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| EP (2) | EP1076699B1 (enExample) |
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| PT (1) | PT2009025E (enExample) |
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| IL117175A (en) | 1995-02-20 | 2005-11-20 | Sankyo Co | Osteoclastogenesis inhibitory factor protein |
| DE69738811D1 (de) * | 1996-12-13 | 2008-08-14 | Schering Corp | Oberflächenantigene aus Säugern |
| WO1998028424A2 (en) | 1996-12-23 | 1998-07-02 | Immunex Corporation | Receptor activator of nf-kappa b, receptor is member of tnf receptor superfamily |
| NZ332995A (en) | 1997-04-15 | 2000-07-28 | Snow Brand Milk Products Co Ltd | A protein which binds to osteoclastogenesis inhibitory factor (OCIF) |
| US6316408B1 (en) * | 1997-04-16 | 2001-11-13 | Amgen Inc. | Methods of use for osetoprotegerin binding protein receptors |
| BR9808545A (pt) * | 1997-04-16 | 2000-05-23 | Amgen Inc | ácido nucleico isolado, vetor de expressão, célula hospedeira, processos para produzir uma proteìna de ligação da osteoprotegerina, para detectar a presença de uma proteìna de ligação à osteoprotegerina em uma amostra biológica, para avaliar a capacidade de um composto candidato de ligar-se a uma proteìna de ligação da osteoprotegerina e de um composto de teste para aumentar ou reduzir a ligação da proteìna de ligação da osteoprotegerina a odar, para regular a expressão de uma proteìna de ligação da osteoprotegerina em um animal e para prevenir ou tratar de doença óssea em um mamìfero, polipeptìdeo, protéina de ligação da osteroprotegerina purificada e isolada, ou seu fragmento, análogo ou derivado, e, anticorpo ou seu fragmento |
| AU7705098A (en) * | 1997-05-29 | 1998-12-30 | Human Genome Sciences, Inc. | Human tumor necrosis factor receptor-like protein 8 |
| US6891082B2 (en) * | 1997-08-01 | 2005-05-10 | The Johns Hopkins University School Of Medicine | Transgenic non-human animals expressing a truncated activintype II receptor |
| ATE412746T1 (de) | 1998-05-14 | 2008-11-15 | Immunex Corp | Verfahren zur hemmung der wirkung der osteoklasten |
| US6492333B1 (en) | 1999-04-09 | 2002-12-10 | Osteoscreen, Inc. | Treatment of myeloma bone disease with proteasomal and NF-κB activity inhibitors |
| US6673771B1 (en) | 1999-07-28 | 2004-01-06 | The Trustees Of The University Of Pennsylvania | Methods of inhibiting osteoclast activity |
| EP1207873B1 (en) * | 1999-07-28 | 2009-11-18 | The Trustees Of The University Of Pennsylvania | Methods of inhibiting osteoclast activity |
| US20030103978A1 (en) * | 2000-02-23 | 2003-06-05 | Amgen Inc. | Selective binding agents of osteoprotegerin binding protein |
| EP1399555A2 (en) * | 2001-02-09 | 2004-03-24 | Maxygen Holdings Ltd. c/o Close Brothers (Cayman) Limited | Rank ligand-binding polypeptides |
| EP1385532A4 (en) * | 2001-03-22 | 2004-12-15 | Barnes Jewish Hospital | STIMULATION OF THE OSTEOGENESIS WITH RANG-LIGAND FUSION PROTEINS |
| EP1385872A4 (en) * | 2001-05-11 | 2004-12-15 | Res Dev Foundation | NF-KAPPA B ACTIVATOR RECEPTOR INHIBITORS AND USES OF SUCH INHIBITORS |
| ES2212930T1 (es) * | 2001-05-17 | 2004-08-16 | Immunex Corporation | Uso terapeutico de antagonistas de rank. |
| ES2706902T3 (es) | 2001-06-26 | 2019-04-01 | Amgen Inc | Anticuerpos para OPGL |
| CA2463478A1 (en) * | 2001-10-12 | 2003-08-14 | Barnes-Jewish Hospital | Methods for screening osteogenic compounds |
| US7718776B2 (en) * | 2002-04-05 | 2010-05-18 | Amgen Inc. | Human anti-OPGL neutralizing antibodies as selective OPGL pathway inhibitors |
| AU2003242265A1 (en) * | 2002-06-07 | 2003-12-22 | Sankyo Company, Limited | Combined effects of therapeutic or preventive agent composition for bone breakage |
| TWI359026B (en) * | 2004-02-12 | 2012-03-01 | Sankyo Co | Pharmaceutical composition for the osteoclast rela |
| JP5191487B2 (ja) * | 2007-06-05 | 2013-05-08 | オリエンタル酵母工業株式会社 | 新しい骨量増加薬 |
| JP6403999B2 (ja) * | 2014-06-05 | 2018-10-10 | 株式会社細川洋行 | レトルト包装用積層体及び容器 |
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| US6410516B1 (en) * | 1986-01-09 | 2002-06-25 | President & Fellows Of Harvard College | Nuclear factors associated with transcriptional regulation |
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-
1999
- 1999-05-13 AT AT99923021T patent/ATE412746T1/de not_active IP Right Cessation
- 1999-05-13 AU AU39888/99A patent/AU762574B2/en not_active Expired
- 1999-05-13 JP JP2000548465A patent/JP2002514418A/ja active Pending
- 1999-05-13 ES ES99923021T patent/ES2317694T3/es not_active Expired - Lifetime
- 1999-05-13 AT AT08015570T patent/ATE517916T1/de active
- 1999-05-13 CA CA2328140A patent/CA2328140C/en not_active Expired - Lifetime
- 1999-05-13 DK DK08015570.8T patent/DK2009025T3/da active
- 1999-05-13 EP EP99923021A patent/EP1076699B1/en not_active Expired - Lifetime
- 1999-05-13 DE DE69939822T patent/DE69939822D1/de not_active Expired - Lifetime
- 1999-05-13 EP EP08015570A patent/EP2009025B1/en not_active Expired - Lifetime
- 1999-05-13 PT PT08015570T patent/PT2009025E/pt unknown
- 1999-05-13 WO PCT/US1999/010588 patent/WO1999058674A2/en not_active Ceased
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2004
- 2004-11-30 US US10/999,523 patent/US20050089522A1/en not_active Abandoned
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2008
- 2008-06-11 US US12/137,397 patent/US7790684B2/en not_active Expired - Fee Related
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2011
- 2011-10-06 CY CY20111100954T patent/CY1111912T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT2009025E (pt) | 2011-09-19 |
| JP2002514418A (ja) | 2002-05-21 |
| US20090004196A1 (en) | 2009-01-01 |
| ES2317694T3 (es) | 2009-04-16 |
| CY1111912T1 (el) | 2015-11-04 |
| EP1076699A2 (en) | 2001-02-21 |
| DK2009025T3 (da) | 2011-11-14 |
| US20050089522A1 (en) | 2005-04-28 |
| EP2009025B1 (en) | 2011-07-27 |
| ATE517916T1 (de) | 2011-08-15 |
| WO1999058674A2 (en) | 1999-11-18 |
| US7790684B2 (en) | 2010-09-07 |
| AU3988899A (en) | 1999-11-29 |
| ATE412746T1 (de) | 2008-11-15 |
| AU762574B2 (en) | 2003-06-26 |
| EP1076699B1 (en) | 2008-10-29 |
| WO1999058674A3 (en) | 2000-02-10 |
| EP2009025A1 (en) | 2008-12-31 |
| DE69939822D1 (de) | 2008-12-11 |
| CA2328140A1 (en) | 1999-11-18 |
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