CA2327509A1 - Pth2 receptor selective compounds - Google Patents

Pth2 receptor selective compounds Download PDF

Info

Publication number
CA2327509A1
CA2327509A1 CA002327509A CA2327509A CA2327509A1 CA 2327509 A1 CA2327509 A1 CA 2327509A1 CA 002327509 A CA002327509 A CA 002327509A CA 2327509 A CA2327509 A CA 2327509A CA 2327509 A1 CA2327509 A1 CA 2327509A1
Authority
CA
Canada
Prior art keywords
deleted
phe
aib
acc
hpth
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002327509A
Other languages
English (en)
French (fr)
Inventor
Michael Chorev
Zheng Xin Dong
Michael Rosenblatt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ipsen Pharma SAS
Beth Israel Deaconess Medical Center Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2327509A1 publication Critical patent/CA2327509A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA002327509A 1998-05-05 1999-05-03 Pth2 receptor selective compounds Abandoned CA2327509A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7295698A 1998-05-05 1998-05-05
US09/072,956 1998-05-05
PCT/US1999/009521 WO1999057139A2 (en) 1998-05-05 1999-05-03 Pth2 receptor selective compounds

Publications (1)

Publication Number Publication Date
CA2327509A1 true CA2327509A1 (en) 1999-11-11

Family

ID=22110801

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002327509A Abandoned CA2327509A1 (en) 1998-05-05 1999-05-03 Pth2 receptor selective compounds

Country Status (12)

Country Link
US (2) US7531621B1 (enExample)
EP (1) EP1075491B1 (enExample)
JP (1) JP4460157B2 (enExample)
AT (1) ATE392431T1 (enExample)
AU (1) AU3673699A (enExample)
CA (1) CA2327509A1 (enExample)
DE (1) DE69938548T2 (enExample)
ES (1) ES2302374T3 (enExample)
HU (1) HUP0300891A2 (enExample)
NO (1) NO20005556L (enExample)
PL (1) PL344645A1 (enExample)
WO (1) WO1999057139A2 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK40599A3 (en) 1996-09-26 2000-06-12 Chugai Pharmaceutical Co Ltd Antibody against human parathormone related peptides
UA74130C2 (uk) 1997-05-15 2005-11-15 Чугаі Сейяку Кабусікі Кайся ЗАСТОСУВАННЯ АНТИТІЛА ПРОТИ БІЛКА, СПОРІДНЕНОГО З ПАРАТИРЕОЇДНИМ ГОРМОНОМ (PTHrP), АБО ЙОГО ФУНКЦІОНАЛЬНО АКТИВНОГО ФРАГМЕНТА І/АБО ЙОГО МОДИФІКОВАНОГО ФРАГМЕНТА ДЛЯ ВИРОБНИЦТВА ЛІКАРСЬКОГО ЗАСОБУ ДЛЯ ПРОФІЛАКТИКИ АБО ЛІКУВАННЯ КАХЕКСІЇ
TWI255718B (en) 1999-07-02 2006-06-01 Chugai Pharmaceutical Co Ltd Ameliorative agent for low vasopressin concentration
CA2373885A1 (en) * 1999-07-02 2001-01-11 Chugai Seiyaku Kabushiki Kaisha Therapeutic agent for diseases caused by pth or pthrp
EP1987842A1 (en) 2000-04-28 2008-11-05 Chugai Seiyaku Kabushiki Kaisha Cell proliferation inhibitor
AU2001292905A1 (en) * 2000-09-19 2002-04-02 Curagen Corporation Method of identifying osteoregenerative agents using differential gene expression
WO2004071396A2 (en) * 2003-02-17 2004-08-26 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with parathyroid hormone receptor 2 (pthr2)
CN101522709B (zh) 2006-10-13 2013-03-20 伊莱利利公司 作为pth受体调节剂的聚乙二醇化的pth及其用途
JP5711966B2 (ja) 2007-08-01 2015-05-07 ザ ジェネラル ホスピタル コーポレイション Ｇタンパク質共役受容体および関連組成物を使用するスクリーニング方法
MX358161B (es) 2010-05-13 2018-08-06 The General Hospital Corp Star Analogos de hormona paratiroidea y usos para los mismos.

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0293158A3 (en) 1987-05-26 1990-05-09 Merck & Co. Inc. Parathyroid hormone antagonists
US5001223A (en) * 1987-05-26 1991-03-19 Merck & Co., Inc. Parathyroid hormone antagonists with enhanced metabolic properties
US5527772A (en) 1987-10-20 1996-06-18 Holick; Michael F. Regulation of cell proliferation and differentiation using peptides
US4968669A (en) 1988-05-09 1990-11-06 Merck & Co., Inc. Parathyroid hormone antagonists
DE68921665T2 (de) 1988-05-09 1995-09-21 Merck & Co Inc Hemmer vom flüssigen kalziumerhöhenden Faktor.
CA2040264A1 (en) 1990-04-12 1991-10-13 Tatsuhiko Kanmera Parathyroid hormone antagonists
US5087562A (en) 1990-04-25 1992-02-11 Merck & Co., Inc. Humoral hypercalcemic factor antagonists with modification at position 13 . . .
US5093233A (en) 1990-04-25 1992-03-03 Merck & Co., Inc. Antagonists with position 13 modification
US5149779A (en) 1990-07-26 1992-09-22 Merck & Co., Inc. Humoral hypercalcemic factor antagonists
JPH0532696A (ja) 1990-09-28 1993-02-09 Takeda Chem Ind Ltd 副甲状腺ホルモン誘導体
CA2098283A1 (en) 1990-12-21 1992-06-22 Richard P. Bozzato Oxidation resistant variants of parathyroid hormone
DE4203040A1 (de) 1992-02-04 1993-08-05 Boehringer Mannheim Gmbh Neue parathormonfragmente, deren herstellung und diese enthaltende arzneimittel
US5589452A (en) 1992-07-14 1996-12-31 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
AU672790B2 (en) 1992-07-15 1996-10-17 Novartis Ag Variants of parathyroid hormone and its fragments
CA2126299C (en) * 1994-06-20 2000-12-12 Gordon E. Willick Parathyroid hormone analogues for the treatment of osteoporosis
US5747456A (en) 1994-12-19 1998-05-05 Beth Israel Deaconess Medical Center Continuous low-dose administration of parathyroid hormone or its agonist
US5717062A (en) 1995-06-07 1998-02-10 Beth Israel Hospital Association Cyclic analogs of PTH and PTHrP
US5955574A (en) * 1995-07-13 1999-09-21 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A. Analogs of parathyroid hormone
US5723577A (en) 1995-07-13 1998-03-03 Biomeasure Inc. Analogs of parathyroid hormone
US5969095A (en) 1995-07-13 1999-10-19 Biomeasure, Inc. Analogs of parathyroid hormone
JP3259011B2 (ja) * 1995-08-02 2002-02-18 ミヤチテクノス株式会社 インバータ式抵抗溶接制御方法及び装置
ATE304020T1 (de) 1996-07-31 2005-09-15 Gen Hospital Corp Parathyroidhormon-verwandthe peptidanaloge

Also Published As

Publication number Publication date
US7531621B1 (en) 2009-05-12
ATE392431T1 (de) 2008-05-15
EP1075491B1 (en) 2008-04-16
WO1999057139A3 (en) 2000-02-03
DE69938548T2 (de) 2009-06-18
JP4460157B2 (ja) 2010-05-12
HUP0300891A2 (hu) 2003-07-28
DE69938548D1 (de) 2008-05-29
PL344645A1 (en) 2001-11-19
WO1999057139A2 (en) 1999-11-11
NO20005556D0 (no) 2000-11-03
US20090226477A1 (en) 2009-09-10
AU3673699A (en) 1999-11-23
NO20005556L (no) 2001-01-03
JP2002513801A (ja) 2002-05-14
EP1075491A2 (en) 2001-02-14
ES2302374T3 (es) 2008-07-01

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued