CA2325360C - Compositions comprising osteoprotegerin for the prevention and treatment of cardiovascular diseases - Google Patents
Compositions comprising osteoprotegerin for the prevention and treatment of cardiovascular diseases Download PDFInfo
- Publication number
- CA2325360C CA2325360C CA002325360A CA2325360A CA2325360C CA 2325360 C CA2325360 C CA 2325360C CA 002325360 A CA002325360 A CA 002325360A CA 2325360 A CA2325360 A CA 2325360A CA 2325360 C CA2325360 C CA 2325360C
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- Prior art keywords
- opg
- osteoprotegerin
- pharmaceutical composition
- polypeptide
- composition
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/064,832 | 1998-04-23 | ||
| US09/064,832 US6790823B1 (en) | 1998-04-23 | 1998-04-23 | Compositions and methods for the prevention and treatment of cardiovascular diseases |
| PCT/US1999/008793 WO1999053942A1 (en) | 1998-04-23 | 1999-04-21 | Compositions comprising osteoprotegerin for the prevention and treatment of cardiovascular diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2325360A1 CA2325360A1 (en) | 1999-10-28 |
| CA2325360C true CA2325360C (en) | 2008-11-04 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002325360A Expired - Fee Related CA2325360C (en) | 1998-04-23 | 1999-04-21 | Compositions comprising osteoprotegerin for the prevention and treatment of cardiovascular diseases |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6790823B1 (https=) |
| EP (1) | EP1073456B1 (https=) |
| JP (1) | JP4776774B2 (https=) |
| AT (1) | ATE303817T1 (https=) |
| AU (1) | AU757806B2 (https=) |
| CA (1) | CA2325360C (https=) |
| DE (1) | DE69927147T2 (https=) |
| DK (1) | DK1073456T3 (https=) |
| ES (1) | ES2248998T3 (https=) |
| SI (1) | SI1073456T1 (https=) |
| WO (1) | WO1999053942A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL117175A (en) | 1995-02-20 | 2005-11-20 | Sankyo Co | Osteoclastogenesis inhibitory factor protein |
| US6242213B1 (en) | 1996-12-23 | 2001-06-05 | Immunex Corporation | Isolated DNA molecules encoding RANK-L |
| WO1999058674A2 (en) | 1998-05-14 | 1999-11-18 | Immunex Corporation | Method of inhibiting osteoclast activity |
| KR100496063B1 (ko) | 1997-04-15 | 2005-06-21 | 산쿄 가부시키가이샤 | 신규단백질 및 그 제조방법 |
| EP0975754B2 (en) | 1997-04-16 | 2016-01-06 | Amgen Inc., | Osteoprotegerin binding proteins and their receptors |
| US6316408B1 (en) | 1997-04-16 | 2001-11-13 | Amgen Inc. | Methods of use for osetoprotegerin binding protein receptors |
| JP4380067B2 (ja) * | 1998-04-23 | 2009-12-09 | 味の素株式会社 | 抗血栓活性物質及びグリコカリシンの検出法 |
| JP4921687B2 (ja) * | 2001-04-03 | 2012-04-25 | ソシエテ・デ・プロデュイ・ネスレ・エス・アー | 乳中の破骨細胞分化抑制因子 |
| US7198798B2 (en) * | 2001-05-10 | 2007-04-03 | University Of Washington | Methods and devices for promoting endothelial morphogenesis |
| MXPA03010747A (es) | 2001-05-25 | 2004-03-02 | Human Genome Sciences Inc | Anticuerpos que se unen inmunoespecificamente a receptores de ligando inductor de apoptosis relacionado con factor de necrosis tumoral. |
| US8649843B2 (en) * | 2001-11-24 | 2014-02-11 | Ben A. Arnold | Automated calcium scoring of the aorta |
| WO2003086289A2 (en) | 2002-04-05 | 2003-10-23 | Amgen Inc. | Human anti-opgl neutralizing antibodies as selective opgl pathway inhibitors |
| US7585840B2 (en) | 2002-04-10 | 2009-09-08 | Merck Serono S.A. | Use of osteoprotegerin for the treatment and/or prevention of fibrotic disease |
| EP1515743A2 (en) | 2002-04-10 | 2005-03-23 | Applied Research Systems ARS Holding N.V. | Use of osteoprotegerin for the prevention and/or treatment of fibrosis/sclerosis |
| CA2584510C (en) | 2004-10-25 | 2013-05-28 | Intezyne Technologies, Incorporated | Heterobifunctional poly(ethylene glycol) and uses thereof |
| EP2067801A1 (en) | 2005-01-04 | 2009-06-10 | Intezyne Technologies Incorporated | Synthesis of Hybrid Block Copolymers |
| US7463758B2 (en) * | 2005-06-02 | 2008-12-09 | Nordio Bioscience A/S | Method of deriving a quantitative measure of a degree of calcification of an aorta |
| US7561727B2 (en) * | 2005-06-02 | 2009-07-14 | Nordic Bioscience Imaging A/S | Method of deriving a quantitative measure of a degree of calcification of an aorta |
| EP2433644A1 (en) * | 2010-09-22 | 2012-03-28 | IMBA-Institut für Molekulare Biotechnologie GmbH | Breast cancer therapeutics |
| FR2970870A1 (fr) * | 2011-01-31 | 2012-08-03 | Centre Nat Rech Scient | Modulation de la proliferation des cellules epitheliales de l'unite epidermo-pilo-sebacee via rank |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US6936694B1 (en) | 1982-05-06 | 2005-08-30 | Intermune, Inc. | Manufacture and expression of large structural genes |
| JP2877509B2 (ja) | 1989-05-19 | 1999-03-31 | アムジエン・インコーポレーテツド | メタロプロテイナーゼ阻害剤 |
| US5580722A (en) * | 1989-07-18 | 1996-12-03 | Oncogene Science, Inc. | Methods of determining chemicals that modulate transcriptionally expression of genes associated with cardiovascular disease |
| US6369027B1 (en) | 1995-12-22 | 2002-04-09 | Amgen Inc. | Osteoprotegerin |
-
1998
- 1998-04-23 US US09/064,832 patent/US6790823B1/en not_active Expired - Fee Related
-
1999
- 1999-04-21 JP JP2000544345A patent/JP4776774B2/ja not_active Expired - Fee Related
- 1999-04-21 EP EP99918766A patent/EP1073456B1/en not_active Expired - Lifetime
- 1999-04-21 CA CA002325360A patent/CA2325360C/en not_active Expired - Fee Related
- 1999-04-21 DE DE69927147T patent/DE69927147T2/de not_active Expired - Lifetime
- 1999-04-21 AU AU36605/99A patent/AU757806B2/en not_active Ceased
- 1999-04-21 SI SI9930826T patent/SI1073456T1/sl unknown
- 1999-04-21 AT AT99918766T patent/ATE303817T1/de active
- 1999-04-21 WO PCT/US1999/008793 patent/WO1999053942A1/en not_active Ceased
- 1999-04-21 ES ES99918766T patent/ES2248998T3/es not_active Expired - Lifetime
- 1999-04-21 DK DK99918766T patent/DK1073456T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| EP1073456A1 (en) | 2001-02-07 |
| DK1073456T3 (da) | 2005-10-24 |
| ES2248998T3 (es) | 2006-03-16 |
| DE69927147T2 (de) | 2006-01-26 |
| AU3660599A (en) | 1999-11-08 |
| EP1073456B1 (en) | 2005-09-07 |
| JP4776774B2 (ja) | 2011-09-21 |
| WO1999053942A8 (en) | 1999-12-02 |
| DE69927147D1 (de) | 2005-10-13 |
| SI1073456T1 (sl) | 2005-12-31 |
| WO1999053942A1 (en) | 1999-10-28 |
| JP2002512199A (ja) | 2002-04-23 |
| US6790823B1 (en) | 2004-09-14 |
| ATE303817T1 (de) | 2005-09-15 |
| AU757806B2 (en) | 2003-03-06 |
| CA2325360A1 (en) | 1999-10-28 |
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