ATE303817T1 - Verwendung von osteoprotegerin zur vorbeugung und behandlung cardiovaskulärer erkrankungen - Google Patents

Verwendung von osteoprotegerin zur vorbeugung und behandlung cardiovaskulärer erkrankungen

Info

Publication number
ATE303817T1
ATE303817T1 AT99918766T AT99918766T ATE303817T1 AT E303817 T1 ATE303817 T1 AT E303817T1 AT 99918766 T AT99918766 T AT 99918766T AT 99918766 T AT99918766 T AT 99918766T AT E303817 T1 ATE303817 T1 AT E303817T1
Authority
AT
Austria
Prior art keywords
osteoprotegerin
cardiovascular diseases
preventing
treating cardiovascular
opg
Prior art date
Application number
AT99918766T
Other languages
German (de)
English (en)
Inventor
Scott Simonet
Ildiko Sarosi
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Application granted granted Critical
Publication of ATE303817T1 publication Critical patent/ATE303817T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT99918766T 1998-04-23 1999-04-21 Verwendung von osteoprotegerin zur vorbeugung und behandlung cardiovaskulärer erkrankungen ATE303817T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/064,832 US6790823B1 (en) 1998-04-23 1998-04-23 Compositions and methods for the prevention and treatment of cardiovascular diseases
PCT/US1999/008793 WO1999053942A1 (en) 1998-04-23 1999-04-21 Compositions comprising osteoprotegerin for the prevention and treatment of cardiovascular diseases

Publications (1)

Publication Number Publication Date
ATE303817T1 true ATE303817T1 (de) 2005-09-15

Family

ID=22058524

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99918766T ATE303817T1 (de) 1998-04-23 1999-04-21 Verwendung von osteoprotegerin zur vorbeugung und behandlung cardiovaskulärer erkrankungen

Country Status (11)

Country Link
US (1) US6790823B1 (https=)
EP (1) EP1073456B1 (https=)
JP (1) JP4776774B2 (https=)
AT (1) ATE303817T1 (https=)
AU (1) AU757806B2 (https=)
CA (1) CA2325360C (https=)
DE (1) DE69927147T2 (https=)
DK (1) DK1073456T3 (https=)
ES (1) ES2248998T3 (https=)
SI (1) SI1073456T1 (https=)
WO (1) WO1999053942A1 (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL117175A (en) 1995-02-20 2005-11-20 Sankyo Co Osteoclastogenesis inhibitory factor protein
US6242213B1 (en) 1996-12-23 2001-06-05 Immunex Corporation Isolated DNA molecules encoding RANK-L
WO1999058674A2 (en) 1998-05-14 1999-11-18 Immunex Corporation Method of inhibiting osteoclast activity
KR100496063B1 (ko) 1997-04-15 2005-06-21 산쿄 가부시키가이샤 신규단백질 및 그 제조방법
EP0975754B2 (en) 1997-04-16 2016-01-06 Amgen Inc., Osteoprotegerin binding proteins and their receptors
US6316408B1 (en) 1997-04-16 2001-11-13 Amgen Inc. Methods of use for osetoprotegerin binding protein receptors
JP4380067B2 (ja) * 1998-04-23 2009-12-09 味の素株式会社 抗血栓活性物質及びグリコカリシンの検出法
JP4921687B2 (ja) * 2001-04-03 2012-04-25 ソシエテ・デ・プロデュイ・ネスレ・エス・アー 乳中の破骨細胞分化抑制因子
US7198798B2 (en) * 2001-05-10 2007-04-03 University Of Washington Methods and devices for promoting endothelial morphogenesis
MXPA03010747A (es) 2001-05-25 2004-03-02 Human Genome Sciences Inc Anticuerpos que se unen inmunoespecificamente a receptores de ligando inductor de apoptosis relacionado con factor de necrosis tumoral.
US8649843B2 (en) * 2001-11-24 2014-02-11 Ben A. Arnold Automated calcium scoring of the aorta
WO2003086289A2 (en) 2002-04-05 2003-10-23 Amgen Inc. Human anti-opgl neutralizing antibodies as selective opgl pathway inhibitors
US7585840B2 (en) 2002-04-10 2009-09-08 Merck Serono S.A. Use of osteoprotegerin for the treatment and/or prevention of fibrotic disease
EP1515743A2 (en) 2002-04-10 2005-03-23 Applied Research Systems ARS Holding N.V. Use of osteoprotegerin for the prevention and/or treatment of fibrosis/sclerosis
CA2584510C (en) 2004-10-25 2013-05-28 Intezyne Technologies, Incorporated Heterobifunctional poly(ethylene glycol) and uses thereof
EP2067801A1 (en) 2005-01-04 2009-06-10 Intezyne Technologies Incorporated Synthesis of Hybrid Block Copolymers
US7463758B2 (en) * 2005-06-02 2008-12-09 Nordio Bioscience A/S Method of deriving a quantitative measure of a degree of calcification of an aorta
US7561727B2 (en) * 2005-06-02 2009-07-14 Nordic Bioscience Imaging A/S Method of deriving a quantitative measure of a degree of calcification of an aorta
EP2433644A1 (en) * 2010-09-22 2012-03-28 IMBA-Institut für Molekulare Biotechnologie GmbH Breast cancer therapeutics
FR2970870A1 (fr) * 2011-01-31 2012-08-03 Centre Nat Rech Scient Modulation de la proliferation des cellules epitheliales de l'unite epidermo-pilo-sebacee via rank

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US6936694B1 (en) 1982-05-06 2005-08-30 Intermune, Inc. Manufacture and expression of large structural genes
JP2877509B2 (ja) 1989-05-19 1999-03-31 アムジエン・インコーポレーテツド メタロプロテイナーゼ阻害剤
US5580722A (en) * 1989-07-18 1996-12-03 Oncogene Science, Inc. Methods of determining chemicals that modulate transcriptionally expression of genes associated with cardiovascular disease
US6369027B1 (en) 1995-12-22 2002-04-09 Amgen Inc. Osteoprotegerin

Also Published As

Publication number Publication date
EP1073456A1 (en) 2001-02-07
DK1073456T3 (da) 2005-10-24
ES2248998T3 (es) 2006-03-16
DE69927147T2 (de) 2006-01-26
AU3660599A (en) 1999-11-08
CA2325360C (en) 2008-11-04
EP1073456B1 (en) 2005-09-07
JP4776774B2 (ja) 2011-09-21
WO1999053942A8 (en) 1999-12-02
DE69927147D1 (de) 2005-10-13
SI1073456T1 (sl) 2005-12-31
WO1999053942A1 (en) 1999-10-28
JP2002512199A (ja) 2002-04-23
US6790823B1 (en) 2004-09-14
AU757806B2 (en) 2003-03-06
CA2325360A1 (en) 1999-10-28

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