CA2311903A1 - Conteneur a compartiments multiples pour solution medicale - Google Patents
Conteneur a compartiments multiples pour solution medicale Download PDFInfo
- Publication number
- CA2311903A1 CA2311903A1 CA002311903A CA2311903A CA2311903A1 CA 2311903 A1 CA2311903 A1 CA 2311903A1 CA 002311903 A CA002311903 A CA 002311903A CA 2311903 A CA2311903 A CA 2311903A CA 2311903 A1 CA2311903 A1 CA 2311903A1
- Authority
- CA
- Canada
- Prior art keywords
- glucose
- concentration
- calcium
- contents
- compartment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000008155 medical solution Substances 0.000 title claims abstract description 24
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 73
- 239000008103 glucose Substances 0.000 claims abstract description 73
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 57
- 239000011575 calcium Substances 0.000 claims abstract description 57
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 57
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims abstract description 28
- 229910001424 calcium ion Inorganic materials 0.000 claims abstract description 28
- 239000000243 solution Substances 0.000 claims abstract description 22
- 239000000385 dialysis solution Substances 0.000 claims abstract description 21
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims abstract description 18
- 238000000502 dialysis Methods 0.000 claims abstract description 11
- 238000002156 mixing Methods 0.000 claims abstract description 10
- 238000003860 storage Methods 0.000 claims abstract description 7
- 230000007774 longterm Effects 0.000 claims abstract description 6
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims description 18
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 claims description 4
- 229910001425 magnesium ion Inorganic materials 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract description 22
- 239000011780 sodium chloride Substances 0.000 abstract description 11
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 abstract description 4
- 239000001540 sodium lactate Substances 0.000 abstract description 4
- 229940005581 sodium lactate Drugs 0.000 abstract description 4
- 235000011088 sodium lactate Nutrition 0.000 abstract description 4
- 238000000108 ultra-filtration Methods 0.000 abstract description 4
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 abstract 1
- 235000002639 sodium chloride Nutrition 0.000 abstract 1
- 239000000203 mixture Substances 0.000 description 16
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 14
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 12
- 239000012528 membrane Substances 0.000 description 11
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 7
- 239000000872 buffer Substances 0.000 description 7
- 239000001110 calcium chloride Substances 0.000 description 7
- 229910001628 calcium chloride Inorganic materials 0.000 description 7
- 229910001629 magnesium chloride Inorganic materials 0.000 description 7
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 6
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 6
- 229910000019 calcium carbonate Inorganic materials 0.000 description 6
- 239000011777 magnesium Substances 0.000 description 6
- 229910052749 magnesium Inorganic materials 0.000 description 6
- 229910019142 PO4 Inorganic materials 0.000 description 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 5
- 239000010452 phosphate Substances 0.000 description 5
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 229940001447 lactate Drugs 0.000 description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 235000017557 sodium bicarbonate Nutrition 0.000 description 3
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 208000007101 Muscle Cramp Diseases 0.000 description 2
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000011259 mixed solution Substances 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 230000002308 calcification Effects 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 238000001631 haemodialysis Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000004220 muscle function Effects 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2093—Containers having several compartments for products to be mixed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1654—Dialysates therefor
- A61M1/1656—Apparatus for preparing dialysates
- A61M1/1668—Details of containers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/28—Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
- A61M1/287—Dialysates therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/10—Bag-type containers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/202—Separating means
- A61J1/2027—Separating means having frangible parts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/28—Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Fluid Mechanics (AREA)
- External Artificial Organs (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L'invention concerne un conteneur pour solution médicale, destiné en particulier à la dialyse péritonéale. Un compartiment de grande taille (10) contient la majeure partie de la solution médicale (par exemple, bicarbonate de soude, lactate de sodium et chlorure de sodium). En outre, plusieurs compartiments de petite taille (14, 15) sont prévus pour contenir des quantités partielles de la solution médicale, dont le stockage à long terme n'est pas compatible avec le contenu du compartiment de grande taille (par exemple, ions calcium et glucose). En mélangeant le contenu du premier (14) ou du second (15) des compartiments de petite taille avec le contenu du compartiment de grande taille (10), on obtient une solution qui renferme 1,5 ou 2,5 % de glucose et 1,0 ou 1,6 mM de calcium. En mélangeant le contenu des compartiments de petite taille avec celui des compartiments de grande taille, on obtient une solution qui renferme 4,0 % de glucose et 2,5 mM de calcium. Par suite d'une ultrafiltration accrue à forte concentration de glucose, les solutions médicales de ce type sont neutres du point de vue du calcium lorsqu'on les utilise comme solutions de dialyse péritonéale.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9704386-3 | 1997-11-28 | ||
SE9704386A SE512349C2 (sv) | 1997-11-28 | 1997-11-28 | Flerkammarbehållare för medicinsk lösning, förfarnde för beredning av medicinsk lösning för peritonealdialys samt användning av sådan behållare vid beredning av medicinsk lösning |
PCT/SE1998/002146 WO1999027885A1 (fr) | 1997-11-28 | 1998-11-27 | Conteneur a compartiments multiples pour solution medicale |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2311903A1 true CA2311903A1 (fr) | 1999-06-10 |
Family
ID=20409165
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002311903A Abandoned CA2311903A1 (fr) | 1997-11-28 | 1998-11-27 | Conteneur a compartiments multiples pour solution medicale |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP1035823A1 (fr) |
JP (1) | JP2001524353A (fr) |
KR (1) | KR20010032191A (fr) |
CN (1) | CN1280481A (fr) |
AU (1) | AU742793B2 (fr) |
BR (1) | BR9815055A (fr) |
CA (1) | CA2311903A1 (fr) |
SE (1) | SE512349C2 (fr) |
WO (1) | WO1999027885A1 (fr) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996001118A1 (fr) | 1994-07-01 | 1996-01-18 | Baxter International Inc. | Solutions de dialyse peritoneale equilibrees sur le plan biochimique |
US6764481B1 (en) * | 1997-10-27 | 2004-07-20 | Otsuka Pharmaceutical Factory, Inc. | Packaged ophthalmic perfusate and cleaning fluid bag |
DE19912850B4 (de) † | 1999-03-22 | 2005-04-07 | Fresenius Medical Care Deutschland Gmbh | Lösung, insbesondere für Hämo- oder Peritonealdialyse, sowie Verfahren zu deren Herstellung |
SE9903331D0 (sv) | 1999-09-16 | 1999-09-16 | Gambro Lundia Ab | Method and apparatus for sterilising a heat sensitive fluid |
EP1165148A1 (fr) | 1999-03-30 | 2002-01-02 | Gambro Lundia AB | Procede et appareil de sterilisation d'un fluide sensible a la chaleur |
US7122210B2 (en) † | 2002-01-11 | 2006-10-17 | Baxter International Inc. | Bicarbonate-based solutions for dialysis therapies |
DE60321213D1 (de) * | 2002-12-10 | 2008-07-03 | Gambro Lundia Ab | Verfahren zur zubereitung einer medizinischen lösung zur herstellung eines medikaments für dieperitonealdialyse |
SE524530C2 (sv) * | 2002-12-10 | 2004-08-24 | Gambro Lundia Ab | Metod för att framställa en medicinsk lösning för peritonealdialys där en lösning innehållandes ett eller flera acetylerade eller deacetylerade aminosocker värme- eller strålningssteriliseras med bestämda pH-värden och med bestämda viktsprocent för att undvika att cytotoxiska produkter bildas. |
DE60322738D1 (de) | 2002-12-10 | 2008-09-18 | Gambro Lundia Ab | Verfahren zur herstellung einer medizinischen lösung zur herstellung eines medikaments für die peritonealdialyse |
SE524531C2 (sv) * | 2002-12-10 | 2004-08-24 | Gambro Lundia Ab | Metod för att framställa en medicinsk lösning för peritonealdialys där en lösning innehållandes ett eller flera acetylerade eller deacetylerade aminosocker värme- eller strålningssteriliseras med bestämda pH-värden och med bestämda viktsprocent för att undvika att cytotoxiska produkter bildas |
SE0301577L (sv) | 2003-05-28 | 2004-11-29 | Gambro Lundia Ab | Lösning med låg natriumhalt |
US9004761B2 (en) | 2006-05-01 | 2015-04-14 | Baxter International Inc. | Multiple chamber container with mistake proof administration system |
DE102010039489A1 (de) * | 2010-08-18 | 2012-02-23 | Fresenius Medical Care Deutschland Gmbh | Konzentrat |
EP3003358B1 (fr) | 2013-06-07 | 2021-03-24 | Allena Pharmaceuticals Inc. | Compositions et dispositifs de dialyse |
DK178893B1 (en) * | 2015-07-05 | 2017-05-01 | Dorte Dyrsborg | Intravenous Bag |
WO2017038959A1 (fr) * | 2015-09-03 | 2017-03-09 | 太 宮崎 | Préparation en kit et procédé de réglage de dose |
DE102018103937A1 (de) * | 2018-02-21 | 2019-08-22 | Fresenius Medical Care Deutschland Gmbh | Vorrichtung enthaltend Dialyselösung oder Dialyselösungskonzentrat |
EP3838246A4 (fr) | 2018-08-17 | 2022-11-23 | Regimen Kit, Inc. | Procédé de gestion de médicament pour formulation en kit nécessitant un ajustement de dose |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH686778A5 (fr) * | 1987-05-29 | 1996-06-28 | Vifor Medical Ag | Récipient destiné au stockage séparé de composés actifs et à leur mélange subséquent. |
EP0442406B1 (fr) * | 1990-02-14 | 1995-07-26 | Material Engineering Technology Laboratory, Inc. | Récipient de mélange autocontenu, rempli et scellé |
-
1997
- 1997-11-28 SE SE9704386A patent/SE512349C2/sv not_active IP Right Cessation
-
1998
- 1998-11-27 BR BR9815055-3A patent/BR9815055A/pt unknown
- 1998-11-27 KR KR1020007005381A patent/KR20010032191A/ko not_active Application Discontinuation
- 1998-11-27 EP EP98959333A patent/EP1035823A1/fr not_active Withdrawn
- 1998-11-27 AU AU15153/99A patent/AU742793B2/en not_active Ceased
- 1998-11-27 JP JP2000522874A patent/JP2001524353A/ja active Pending
- 1998-11-27 WO PCT/SE1998/002146 patent/WO1999027885A1/fr not_active Application Discontinuation
- 1998-11-27 CA CA002311903A patent/CA2311903A1/fr not_active Abandoned
- 1998-11-27 CN CN98811625A patent/CN1280481A/zh active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2001524353A (ja) | 2001-12-04 |
EP1035823A1 (fr) | 2000-09-20 |
SE9704386L (sv) | 1999-05-29 |
AU1515399A (en) | 1999-06-16 |
KR20010032191A (ko) | 2001-04-16 |
SE512349C2 (sv) | 2000-03-06 |
BR9815055A (pt) | 2002-04-30 |
CN1280481A (zh) | 2001-01-17 |
WO1999027885A1 (fr) | 1999-06-10 |
SE9704386D0 (sv) | 1997-11-28 |
AU742793B2 (en) | 2002-01-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued |