CA2297723A1 - Synthese de compositions de dihydrohonokiol - Google Patents

Synthese de compositions de dihydrohonokiol Download PDF

Info

Publication number
CA2297723A1
CA2297723A1 CA002297723A CA2297723A CA2297723A1 CA 2297723 A1 CA2297723 A1 CA 2297723A1 CA 002297723 A CA002297723 A CA 002297723A CA 2297723 A CA2297723 A CA 2297723A CA 2297723 A1 CA2297723 A1 CA 2297723A1
Authority
CA
Canada
Prior art keywords
compound
och3
cooh
anxiety
diazepam
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002297723A
Other languages
English (en)
Inventor
Rajiv K. Satsangi
William B. Stavinoha
Neera Satsangi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2297723A1 publication Critical patent/CA2297723A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/205—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing only six-membered aromatic rings as cyclic parts with unsaturation outside the rings
    • C07C39/21—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing only six-membered aromatic rings as cyclic parts with unsaturation outside the rings with at least one hydroxy group on a non-condensed ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne la synthèse et l'utilisation du composé anxiolytique dihydrohonokiol, ses dérivés, ses analogues et ses homologues. L'invention concerne également un procédé anxiolytique destiné à un mammifère.
CA002297723A 1997-06-26 1998-06-26 Synthese de compositions de dihydrohonokiol Abandoned CA2297723A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5084597P 1997-06-26 1997-06-26
US60/050845 1997-06-26
PCT/US1998/013265 WO1999000346A1 (fr) 1997-06-26 1998-06-26 Synthese de compositions de dihydrohonokiol

Publications (1)

Publication Number Publication Date
CA2297723A1 true CA2297723A1 (fr) 1999-01-07

Family

ID=21967834

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002297723A Abandoned CA2297723A1 (fr) 1997-06-26 1998-06-26 Synthese de compositions de dihydrohonokiol

Country Status (5)

Country Link
EP (1) EP0991614A1 (fr)
JP (1) JP2002507211A (fr)
AU (1) AU8168998A (fr)
CA (1) CA2297723A1 (fr)
WO (1) WO1999000346A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000040532A2 (fr) * 1998-12-31 2000-07-13 Board Of Regents, The University Of Texas System Synthese de compositions a base de dihydrohonokiol
US20050070537A1 (en) 2002-10-10 2005-03-31 Chris Rundfeldt Use of dihydroimidazolones for the treatment of dogs
AU2006233101B2 (en) * 2005-02-23 2011-09-01 Arbiser, Jack Honokiol derivatives for the treatment of proliferative disorders
CN101279901B (zh) * 2007-12-25 2011-08-17 四川大学 和厚朴酚系列衍生物及其制备方法和用途
EP2423181A1 (fr) 2010-07-28 2012-02-29 Prous Institute For Biomedical Research S.A. Dérivés de biphényldiol substitués à cible multiple
WO2014170902A1 (fr) * 2013-04-17 2014-10-23 Ariel - University Research And Development Company, Ltd. Ligands du récepteur cb2 pour le traitement de troubles psychiatriques
US9820988B2 (en) 2014-03-24 2017-11-21 Boehringer Ingelheim Vetmedica Gmbh Treatment of epileptic disorders in feline animals
CN108883082B (zh) * 2015-06-11 2021-10-26 威斯康星州医药大学股份有限公司 丝-和厚朴酚化合物及其合成和使用方法
US11897910B2 (en) 2015-06-11 2024-02-13 The Medical College Of Wisconsin, Inc. Mito-honokiol compounds and methods of synthesis and use thereof
WO2017070568A1 (fr) * 2015-10-23 2017-04-27 Colgate-Palmolive Company Synthèse améliorée d'honokiol
AU2020326778A1 (en) * 2019-08-06 2022-03-24 Justin KIRKLAND Formulations including dihydrohonokiol
CN112125805B (zh) 2020-09-11 2022-10-18 北京红惠新医药科技有限公司 水溶性厚朴酚衍生物及和厚朴酚衍生物和其中间体的制备方法、和相关的单羟基保护中间体

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5995229A (ja) * 1982-11-24 1984-06-01 Tsumura Juntendo Inc 新規ハイドロオキシビフエニル化合物
DK0382213T3 (da) * 1989-02-08 1995-07-10 Otsuka Pharma Co Ltd Biphenylderivat, middel til reparation af eller beskyttelse mod nervecelledegeneration og fremgangsmåde til fremstilling af et phenylderivat, som indgår i dette middel
US5449682A (en) * 1990-02-13 1995-09-12 Merck & Co., Inc. Angiotensin II antagonists incorporating a substituted benzyl element

Also Published As

Publication number Publication date
EP0991614A1 (fr) 2000-04-12
WO1999000346A1 (fr) 1999-01-07
AU8168998A (en) 1999-01-19
WO1999000346A8 (fr) 2000-02-17
JP2002507211A (ja) 2002-03-05

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