CA2288013A1 - Selectively binding ultrasound contrast agents - Google Patents
Selectively binding ultrasound contrast agents Download PDFInfo
- Publication number
- CA2288013A1 CA2288013A1 CA002288013A CA2288013A CA2288013A1 CA 2288013 A1 CA2288013 A1 CA 2288013A1 CA 002288013 A CA002288013 A CA 002288013A CA 2288013 A CA2288013 A CA 2288013A CA 2288013 A1 CA2288013 A1 CA 2288013A1
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- Prior art keywords
- composition
- microbubble
- biomolecule
- lipid
- binding moiety
- Prior art date
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- QYSGYZVSCZSLHT-UHFFFAOYSA-N octafluoropropane Chemical compound FC(F)(F)C(F)(F)C(F)(F)F QYSGYZVSCZSLHT-UHFFFAOYSA-N 0.000 description 1
- HEGSGKPQLMEBJL-RKQHYHRCSA-N octyl beta-D-glucopyranoside Chemical compound CCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HEGSGKPQLMEBJL-RKQHYHRCSA-N 0.000 description 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- BPHQIXJDBIHMLT-UHFFFAOYSA-N perfluorodecane Chemical class FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F BPHQIXJDBIHMLT-UHFFFAOYSA-N 0.000 description 1
- NJCBUSHGCBERSK-UHFFFAOYSA-N perfluoropentane Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F NJCBUSHGCBERSK-UHFFFAOYSA-N 0.000 description 1
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- 239000000546 pharmaceutical excipient Substances 0.000 description 1
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- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 229920002981 polyvinylidene fluoride Polymers 0.000 description 1
- 229920002717 polyvinylpyridine Polymers 0.000 description 1
- 150000003141 primary amines Chemical class 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 230000009145 protein modification Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 150000003335 secondary amines Chemical class 0.000 description 1
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- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
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- 229960000909 sulfur hexafluoride Drugs 0.000 description 1
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- 238000003786 synthesis reaction Methods 0.000 description 1
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- 235000020679 tap water Nutrition 0.000 description 1
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- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/227—Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric
Landscapes
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Acoustics & Sound (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/863,647 | 1997-05-27 | ||
| US08/863,647 US6245318B1 (en) | 1997-05-27 | 1997-05-27 | Selectively binding ultrasound contrast agents |
| PCT/US1998/010745 WO1998053857A1 (en) | 1997-05-27 | 1998-05-27 | Selectively binding ultrasound contrast agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2288013A1 true CA2288013A1 (en) | 1998-12-03 |
Family
ID=25341485
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002288013A Abandoned CA2288013A1 (en) | 1997-05-27 | 1998-05-27 | Selectively binding ultrasound contrast agents |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6245318B1 (enExample) |
| EP (1) | EP0988062A4 (enExample) |
| JP (1) | JP2002501535A (enExample) |
| AU (1) | AU7600798A (enExample) |
| CA (1) | CA2288013A1 (enExample) |
| WO (1) | WO1998053857A1 (enExample) |
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| AU9400798A (en) * | 1997-09-18 | 1999-04-05 | University Of Pittsburgh | Icam-1 selective echogenic microbubbles |
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| WO2020231954A1 (en) | 2019-05-10 | 2020-11-19 | The University Of North Carolina At Chapel Hill Office Of Technology Commercialization | Methods, systems, and computer readable media for generating images of microvasculature using ultrasound |
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| GB9708265D0 (en) | 1997-04-24 | 1997-06-18 | Nycomed Imaging As | Contrast agents |
| ES2264159T3 (es) | 1996-10-28 | 2006-12-16 | Amersham Health As | Mejoras en/o relacionadas con agentes de diagnostico/terapeuticos. |
| GB9622368D0 (en) | 1996-10-28 | 1997-01-08 | Nycomed Imaging As | Improvements in or relating to diagnostic/therapeutic agents |
-
1997
- 1997-05-27 US US08/863,647 patent/US6245318B1/en not_active Expired - Lifetime
-
1998
- 1998-05-27 WO PCT/US1998/010745 patent/WO1998053857A1/en not_active Ceased
- 1998-05-27 EP EP98923799A patent/EP0988062A4/en not_active Withdrawn
- 1998-05-27 CA CA002288013A patent/CA2288013A1/en not_active Abandoned
- 1998-05-27 JP JP50084899A patent/JP2002501535A/ja active Pending
- 1998-05-27 AU AU76007/98A patent/AU7600798A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002501535A (ja) | 2002-01-15 |
| EP0988062A1 (en) | 2000-03-29 |
| EP0988062A4 (en) | 2003-04-23 |
| AU7600798A (en) | 1998-12-30 |
| WO1998053857A1 (en) | 1998-12-03 |
| US6245318B1 (en) | 2001-06-12 |
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Effective date: 20040527 |