CA2286797C - Procede de preparation de 6,7-dichloro-5-nitro-2,3-dihydroquinoxaline-2,3-dione de haute purete - Google Patents

Procede de preparation de 6,7-dichloro-5-nitro-2,3-dihydroquinoxaline-2,3-dione de haute purete Download PDF

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Publication number
CA2286797C
CA2286797C CA002286797A CA2286797A CA2286797C CA 2286797 C CA2286797 C CA 2286797C CA 002286797 A CA002286797 A CA 002286797A CA 2286797 A CA2286797 A CA 2286797A CA 2286797 C CA2286797 C CA 2286797C
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CA
Canada
Prior art keywords
water
dichloro
dione
dihydroquinoxaline
nitro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002286797A
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English (en)
Other versions
CA2286797A1 (fr
Inventor
Bruce Gaede
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AbbVie Inc
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of CA2286797A1 publication Critical patent/CA2286797A1/fr
Application granted granted Critical
Publication of CA2286797C publication Critical patent/CA2286797C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La présente invention concerne un procédé de préparation de 6,7-dichloro-5-nitro-2,3-dihydroquinoxaline-2,3-dione de haute pureté, qui consiste à recristalliser l2 6,7-dichloro-5-nitro-2,3-dihydroquinoxaline-2,3-dione brut à partir d'une solution d'eau et de solvants fortement polaires.
CA002286797A 1997-04-18 1998-04-20 Procede de preparation de 6,7-dichloro-5-nitro-2,3-dihydroquinoxaline-2,3-dione de haute purete Expired - Fee Related CA2286797C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US84447597A 1997-04-18 1997-04-18
US08/844,475 1997-04-18
PCT/US1998/007966 WO1998047878A1 (fr) 1997-04-18 1998-04-20 Procede de preparation de 6,7-dichloro-5- nitro-2,3-dihydroquinoxaline-2,3-dione de haute purete

Publications (2)

Publication Number Publication Date
CA2286797A1 CA2286797A1 (fr) 1998-10-29
CA2286797C true CA2286797C (fr) 2008-07-15

Family

ID=25292811

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002286797A Expired - Fee Related CA2286797C (fr) 1997-04-18 1998-04-20 Procede de preparation de 6,7-dichloro-5-nitro-2,3-dihydroquinoxaline-2,3-dione de haute purete

Country Status (4)

Country Link
EP (1) EP0975607A1 (fr)
JP (1) JP2001522358A (fr)
CA (1) CA2286797C (fr)
WO (1) WO1998047878A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2416169C (fr) 2000-07-14 2008-09-23 Allergan, Inc. Compositions contenant des composants a activite therapeutique presentant une solubilite amelioree
US8858961B2 (en) 2000-07-14 2014-10-14 Allergan, Inc. Compositions containing alpha-2-adrenergic agonist components
BR0109317A (pt) 2000-07-14 2003-06-17 Allergan Inc Composições contendo componentes agonistas alfa-2-adrenérgicos
US9737531B2 (en) 2012-07-12 2017-08-22 Glytech, Llc Composition and method for treatment of depression and psychosis in humans
CN110996948A (zh) 2017-06-12 2020-04-10 格莱泰施有限责任公司 用nmda拮抗剂和d2/5ht2a或选择性5ht2a拮抗剂治疗抑郁症

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3301024B2 (ja) * 1992-06-22 2002-07-15 ザ・リージェンツ・オブ・ザ・ユニバーシテイ・オブ・カリフォルニア グリシンレセプター拮抗物質及びその用途

Also Published As

Publication number Publication date
EP0975607A1 (fr) 2000-02-02
WO1998047878A1 (fr) 1998-10-29
JP2001522358A (ja) 2001-11-13
CA2286797A1 (fr) 1998-10-29

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