CA2268742A1 - Agonistes recepteurs hematopoietiques chimeriques multifonctionnels - Google Patents
Agonistes recepteurs hematopoietiques chimeriques multifonctionnels Download PDFInfo
- Publication number
- CA2268742A1 CA2268742A1 CA002268742A CA2268742A CA2268742A1 CA 2268742 A1 CA2268742 A1 CA 2268742A1 CA 002268742 A CA002268742 A CA 002268742A CA 2268742 A CA2268742 A CA 2268742A CA 2268742 A1 CA2268742 A1 CA 2268742A1
- Authority
- CA
- Canada
- Prior art keywords
- xaa
- leu
- ser
- ala
- arg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5403—IL-3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
L'invention concerne de nouvelles protéines agonistes réceptrices hématopoïétiques chimériques multifonctionnelles, des ADN qui codent les protéines agonistes réceptrices hématopoïétiques chimériques multifonctionnelles, des procédés de préparation de protéines agonistes réceptrices hématopoïétiques chimériques multifonctionnelles et des procédés d'utilisation des protéines agonistes réceptrices hématopoïétiques chimériques multifonctionnelles.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2962996P | 1996-10-25 | 1996-10-25 | |
US60/029,629 | 1996-10-25 | ||
PCT/US1997/020037 WO1998017810A2 (fr) | 1996-10-25 | 1997-10-23 | Agonistes recepteurs hematopoietiques chimeriques multifonctionnels |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2268742A1 true CA2268742A1 (fr) | 1998-04-30 |
Family
ID=21850035
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002268742A Abandoned CA2268742A1 (fr) | 1996-10-25 | 1997-10-23 | Agonistes recepteurs hematopoietiques chimeriques multifonctionnels |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP0935663A2 (fr) |
JP (1) | JP2001504689A (fr) |
KR (1) | KR100497423B1 (fr) |
AR (1) | AR010041A1 (fr) |
AU (1) | AU725547B2 (fr) |
BR (1) | BR9713668A (fr) |
CA (1) | CA2268742A1 (fr) |
CZ (1) | CZ295843B6 (fr) |
IL (1) | IL129565A0 (fr) |
NO (1) | NO991948L (fr) |
NZ (1) | NZ335382A (fr) |
PL (1) | PL333023A1 (fr) |
RO (1) | RO120919B1 (fr) |
RU (2) | RU2245887C2 (fr) |
TW (2) | TW200413407A (fr) |
WO (1) | WO1998017810A2 (fr) |
ZA (1) | ZA979607B (fr) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5581476A (en) | 1993-01-28 | 1996-12-03 | Amgen Inc. | Computer-based methods and articles of manufacture for preparing G-CSF analogs |
US20020137890A1 (en) * | 1997-03-31 | 2002-09-26 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
EP0973900A1 (fr) * | 1997-04-11 | 2000-01-26 | G.D. Searle & Co. | PROTEINES CHIMERIQUES CONTENANT LE LIGAND flt3 |
BR9905867A (pt) * | 1998-11-06 | 2001-01-23 | Bio Sidus S A | Linhagem celular produtora de eritropoietina humana recombinante e a eritropoietina humana recombinante produzida por esta célula |
WO2002101047A1 (fr) * | 2001-06-12 | 2002-12-19 | Smithkline Beecham Corporation | Procede d'identification de composes modulant les activites du gene 1 de reponse primaire a l'epo, eprg1 |
ATE468862T1 (de) | 2001-07-11 | 2010-06-15 | Maxygen Inc | G-csf konjugate |
WO2005047461A2 (fr) | 2003-08-18 | 2005-05-26 | The Regents Of The University Of California | Bibliotheques d'affichage de polypeptides et procede de fabrication et d'utilisation de celle-ci |
AU2006254543A1 (en) | 2005-06-01 | 2006-12-07 | Maxygen Holdings Ltd. | PEGylated G-CSF polypeptides and methods of producing same |
US7550433B2 (en) * | 2005-06-03 | 2009-06-23 | Affymax, Inc. | Erythropoietin receptor peptide formulations and uses |
US7666817B2 (en) | 2005-08-31 | 2010-02-23 | The Regents Of The University Of California | Cellular libraries of peptide sequences (CLiPS) and methods of using the same |
WO2007098548A1 (fr) * | 2006-03-01 | 2007-09-07 | Apollo Life Sciences Limited | Molécule et chimères de cette molécule |
US8293685B2 (en) * | 2007-07-26 | 2012-10-23 | The Regents Of The University Of California | Methods for enhancing bacterial cell display of proteins and peptides |
WO2015069489A1 (fr) | 2013-11-06 | 2015-05-14 | Merck Patent Gmbh | Biomarqueur prédictif pour thérapie à base de promédicament activé par l'hypoxie |
CA3133830A1 (fr) * | 2019-03-28 | 2020-10-01 | Orionis Biosciences, Inc. | Proteines chimeriques basees sur le ligand de la tyrosine kinase-3 de type fms (flt3l) |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0503050A4 (en) * | 1990-09-28 | 1994-07-06 | Ortho Pharma Corp | Hybrid growth factors |
US5376367A (en) * | 1991-11-22 | 1994-12-27 | Immunex Corporation | Fusion proteins comprising MGF and IL-3 |
US6057133A (en) * | 1992-11-24 | 2000-05-02 | G. D. Searle | Multivariant human IL-3 fusion proteins and their recombinant production |
US5738849A (en) * | 1992-11-24 | 1998-04-14 | G. D. Searle & Co. | Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them |
US5635599A (en) * | 1994-04-08 | 1997-06-03 | The United States Of America As Represented By The Department Of Health And Human Services | Fusion proteins comprising circularly permuted ligands |
-
1997
- 1997-10-23 IL IL12956597A patent/IL129565A0/xx unknown
- 1997-10-23 JP JP51975498A patent/JP2001504689A/ja not_active Abandoned
- 1997-10-23 RU RU99111071/13A patent/RU2245887C2/ru not_active IP Right Cessation
- 1997-10-23 CA CA002268742A patent/CA2268742A1/fr not_active Abandoned
- 1997-10-23 PL PL97333023A patent/PL333023A1/xx unknown
- 1997-10-23 BR BR9713668-9A patent/BR9713668A/pt not_active Application Discontinuation
- 1997-10-23 CZ CZ19991323A patent/CZ295843B6/cs not_active IP Right Cessation
- 1997-10-23 AU AU51652/98A patent/AU725547B2/en not_active Ceased
- 1997-10-23 EP EP97946495A patent/EP0935663A2/fr not_active Withdrawn
- 1997-10-23 WO PCT/US1997/020037 patent/WO1998017810A2/fr not_active Application Discontinuation
- 1997-10-23 NZ NZ335382A patent/NZ335382A/xx unknown
- 1997-10-23 KR KR10-1999-7003635A patent/KR100497423B1/ko not_active IP Right Cessation
- 1997-10-23 RO RO99-00480A patent/RO120919B1/ro unknown
- 1997-10-27 TW TW093111460A patent/TW200413407A/zh unknown
- 1997-10-27 TW TW086116018A patent/TW591035B/zh not_active IP Right Cessation
- 1997-10-27 ZA ZA979607A patent/ZA979607B/xx unknown
- 1997-10-28 AR ARP970104979A patent/AR010041A1/es unknown
-
1999
- 1999-04-23 NO NO991948A patent/NO991948L/no not_active Application Discontinuation
-
2005
- 2005-02-24 RU RU2005105360/13A patent/RU2005105360A/ru not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
NZ335382A (en) | 2001-03-30 |
AU725547B2 (en) | 2000-10-12 |
NO991948L (no) | 1999-06-23 |
ZA979607B (en) | 1999-04-28 |
WO1998017810A2 (fr) | 1998-04-30 |
IL129565A0 (en) | 2000-02-29 |
RO120919B1 (ro) | 2006-09-29 |
RU2245887C2 (ru) | 2005-02-10 |
PL333023A1 (en) | 1999-11-08 |
RU2005105360A (ru) | 2006-08-10 |
KR20000052812A (ko) | 2000-08-25 |
BR9713668A (pt) | 2000-03-08 |
TW591035B (en) | 2004-06-11 |
EP0935663A2 (fr) | 1999-08-18 |
TW200413407A (en) | 2004-08-01 |
KR100497423B1 (ko) | 2005-07-07 |
CZ295843B6 (cs) | 2005-11-16 |
AR010041A1 (es) | 2000-05-17 |
CZ132399A3 (cs) | 1999-12-15 |
AU5165298A (en) | 1998-05-15 |
NO991948D0 (no) | 1999-04-23 |
JP2001504689A (ja) | 2001-04-10 |
WO1998017810A3 (fr) | 1998-10-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDE | Discontinued | ||
FZDE | Discontinued |
Effective date: 20071023 |