BR9713668A - Agonistas de receptores hematopoiéticos quiméricos multifuncionais - Google Patents

Agonistas de receptores hematopoiéticos quiméricos multifuncionais

Info

Publication number
BR9713668A
BR9713668A BR9713668-9A BR9713668A BR9713668A BR 9713668 A BR9713668 A BR 9713668A BR 9713668 A BR9713668 A BR 9713668A BR 9713668 A BR9713668 A BR 9713668A
Authority
BR
Brazil
Prior art keywords
hematopoietic receptor
functional
receptor agonists
chimeric
receptor agonist
Prior art date
Application number
BR9713668-9A
Other languages
English (en)
Inventor
Charles A Mc Wheter
Yiqing Feng
John P Mc Kearn
Nicholas R Staten
Philip R Streeter
John C Minnerly
Nancy I Minster
Susan L Woulfe
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of BR9713668A publication Critical patent/BR9713668A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5403—IL-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Abstract

Patente de Invenção: <B>"AGONISTAS DE RECEPTORES HEMATOPOIéTICOS QUIMéRICOS MULTI-FUNCIONAIS"<D>. Revelados são novas proteínas de agonista de receptor hematopoiético quimérico multi-funcional, DNAs que codificam as proteínas de agonista de receptor hematopoiético quimérico multi-funcional, métodos de produção das proteínas de agonista de receptor hematopoiético quimérico multi-funcional e métodos de uso das proteínas de agonista de receptor hematopoiético multi-funcional.
BR9713668-9A 1996-10-25 1997-10-23 Agonistas de receptores hematopoiéticos quiméricos multifuncionais BR9713668A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2962996P 1996-10-25 1996-10-25
PCT/US1997/020037 WO1998017810A2 (en) 1996-10-25 1997-10-23 Multi-functional chimeric hematopoietic receptor agonists

Publications (1)

Publication Number Publication Date
BR9713668A true BR9713668A (pt) 2000-03-08

Family

ID=21850035

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9713668-9A BR9713668A (pt) 1996-10-25 1997-10-23 Agonistas de receptores hematopoiéticos quiméricos multifuncionais

Country Status (17)

Country Link
EP (1) EP0935663A2 (pt)
JP (1) JP2001504689A (pt)
KR (1) KR100497423B1 (pt)
AR (1) AR010041A1 (pt)
AU (1) AU725547B2 (pt)
BR (1) BR9713668A (pt)
CA (1) CA2268742A1 (pt)
CZ (1) CZ295843B6 (pt)
IL (1) IL129565A0 (pt)
NO (1) NO991948L (pt)
NZ (1) NZ335382A (pt)
PL (1) PL333023A1 (pt)
RO (1) RO120919B1 (pt)
RU (2) RU2245887C2 (pt)
TW (2) TW591035B (pt)
WO (1) WO1998017810A2 (pt)
ZA (1) ZA979607B (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5581476A (en) 1993-01-28 1996-12-03 Amgen Inc. Computer-based methods and articles of manufacture for preparing G-CSF analogs
US20020137890A1 (en) * 1997-03-31 2002-09-26 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
JP2001527396A (ja) * 1997-04-11 2001-12-25 ジー．ディー．サール アンド カンパニー ｆｌｔ３リガンドキメラタンパク質
BR9905867A (pt) * 1998-11-06 2001-01-23 Bio Sidus S A Linhagem celular produtora de eritropoietina humana recombinante e a eritropoietina humana recombinante produzida por esta célula
WO2002101047A1 (en) * 2001-06-12 2002-12-19 Smithkline Beecham Corporation Method of identifying compounds that modulate epo primary response gene 1, eprg1, activities
MXPA04000231A (es) 2001-07-11 2004-05-04 Maxygen Holdings Ltd Conjugados del factor de estimulacion de colonias de granulocitos.
JP4809767B2 (ja) 2003-08-18 2011-11-09 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 発現ベクター、ポリペプチドディスプレイライブラリ、並びにそれらの作製及び使用方法
BRPI0611221A2 (pt) 2005-06-01 2010-08-24 Maxygen Holdings Ltd polipeptÍdeos de g-csf peguilados e mÉtodos de produÇço dos mesmos
US7550433B2 (en) * 2005-06-03 2009-06-23 Affymax, Inc. Erythropoietin receptor peptide formulations and uses
WO2007027935A2 (en) 2005-08-31 2007-03-08 The Regents Of The University Of California Cellular libraries of peptide sequences (clips) and methods of using the same
WO2007098548A1 (en) * 2006-03-01 2007-09-07 Apollo Life Sciences Limited A molecule and chimeric molecules thereof
WO2009014726A1 (en) 2007-07-26 2009-01-29 The Regents Of The University Of California Methods for enhancing bacterial cell display of proteins and peptides
WO2015069489A1 (en) 2013-11-06 2015-05-14 Merck Patent Gmbh Predictive biomarker for hypoxia-activated prodrug therapy
EP3946409A4 (en) * 2019-03-28 2023-06-21 Orionis Biosciences, Inc. CHEMICAL PROTEINS BASED ON FMS-LIKE TYROSINE KINASE-3 LIGAND (FLT3L)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0503050A4 (en) * 1990-09-28 1994-07-06 Ortho Pharma Corp Hybrid growth factors
US5376367A (en) * 1991-11-22 1994-12-27 Immunex Corporation Fusion proteins comprising MGF and IL-3
US5738849A (en) * 1992-11-24 1998-04-14 G. D. Searle & Co. Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them
US6057133A (en) * 1992-11-24 2000-05-02 G. D. Searle Multivariant human IL-3 fusion proteins and their recombinant production
US5635599A (en) * 1994-04-08 1997-06-03 The United States Of America As Represented By The Department Of Health And Human Services Fusion proteins comprising circularly permuted ligands

Also Published As

Publication number Publication date
AR010041A1 (es) 2000-05-17
CZ295843B6 (cs) 2005-11-16
RU2005105360A (ru) 2006-08-10
NO991948D0 (no) 1999-04-23
RO120919B1 (ro) 2006-09-29
EP0935663A2 (en) 1999-08-18
CA2268742A1 (en) 1998-04-30
TW200413407A (en) 2004-08-01
WO1998017810A3 (en) 1998-10-15
NZ335382A (en) 2001-03-30
RU2245887C2 (ru) 2005-02-10
JP2001504689A (ja) 2001-04-10
IL129565A0 (en) 2000-02-29
TW591035B (en) 2004-06-11
NO991948L (no) 1999-06-23
CZ132399A3 (cs) 1999-12-15
KR20000052812A (ko) 2000-08-25
PL333023A1 (en) 1999-11-08
KR100497423B1 (ko) 2005-07-07
ZA979607B (en) 1999-04-28
AU725547B2 (en) 2000-10-12
AU5165298A (en) 1998-05-15
WO1998017810A2 (en) 1998-04-30

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: DE ACORDO COM O ART. 36 DA LPI (LEI 9279/96) 2O, O PEDIDO VOLTA A EXAME SENDO CONSIDERADO NAO PATENTEAVEL PELAS RAZOES EXPOSTAS NO PARECER TECNICO ANTERIOR.

B09T Decision of refusal: decision cancelled [chapter 9.2.1 patent gazette]

Free format text: ANULACAO DO DESPACHO DE 9.2 POR TER SIDO INDEVIDO. REF. A RPI NO 1964 DE 26/08/2008.

B07B Technical examination (opinion): publication cancelled [chapter 7.2 patent gazette]

Free format text: ANULACAO DO PARECER DE CIENCIA (CODIGO 7.1) POR TER SIDO INDEVIDO. REF. A RPI NO 1934 DE 29/01/2008.

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements