TW200413407A

TW200413407A - Multi-functional chimeric hematopoietic receptor agonist-related pharmaceutical compositions

Info

Publication number: TW200413407A
Application number: TW093111460A
Authority: TW
Inventors: Charles A Mcwherter; Yi-Qing Feng; John P Mckearn; Neena L Summers; Nicholas R Staten; R Streeter Philip; C Minnerly John; I Minster Nancy; L Woulfe Susan
Original assignee: Searle & Co
Priority date: 1996-10-25
Filing date: 1997-10-27
Publication date: 2004-08-01
Also published as: NO991948D0; TW591035B; RO120919B1; RU2245887C2; KR100497423B1; BR9713668A; CZ295843B6; EP0935663A2; NO991948L; RU2005105360A; AR010041A1; CA2268742A1; AU725547B2; IL129565A0; KR20000052812A; WO1998017810A2; JP2001504689A; ZA979607B; WO1998017810A3; CZ132399A3

Description

200413407 玫、發明說明：【發明所屬之技術領域】本發明係關於多功能鑲嵌造此鍺山j <血京又岐促效劑。此等多功月匕鑲肷坆血素受體促效劑可、准持袭肷分子各組成份之一或夕種活性，且可顯示較佳、、 <绝血細胞刺激活性及/或較佳之活性特性（其可包括減少邀 ^ ^ u /、個胆造血生長因子相關之不认生物活性），及/或具有較佳^ — 心玍理特性（其可包括較高之 >谷角t度、穩定性、及重折疊效率）。【先前技術】可刺激骨髓細胞之分化及/或增殖之集落刺激因子（CSFs) 已因其恢復造血幹細胞衍生性細胞之抑低含量之醫療潛力而產生許多益處。咸已辨識出人類及氣類系統中之csfs，並根據其活性進行辨別。舉例而言，粒細胞_csf (g_csf) 及巨嗟細胞-CSF (Μ-CSF)可分別刺㈣中性粒細胞及巨嗟細胞集落之活體外形成，而GM-CSF及間白素·3 (lL_y則具有較廣泛之活性，且可同時刺激巨噬細胞、嗜中性及嗜伊紅性粒細胞集落之形成。IL-3亦可刺激肥大細胞、巨核細胞、以及純性及混合之紅細胞集落之形成。 U.S· 4,877,729 及 U.S· 4,959,455 揭示長臂猿 IL3 cDNA 及推導之人類IL-3 DNA序列，以及其所編碼之蛋白質序列。其所揭示之hIL-3在其蛋白質序列之第8位具有絲胺酸而非脯胺酸。國際專利申請案（PCT) WO 88/00598揭示似長臂猿及似人類之IL-3。該hIL_3含有Ser8—Pro8之取代。其亦建議以ser

O:\92\92747.DOC 200413407 取代Cys以破壞雙硫键，並建議於糖基化位點取代一或多胺基酸。 U.S. 4,810,643揭示編碼人類G-CSF之DNA序列。 W Ο 91/02754G揭示一種含有Μ - C S F及IL - 3之融合蛋白’ 其在與單獨之GM-CSF及IL-3比較之下，具有較佳之生物活性。其亦揭示未經糖基化之IL-3及GM-CSF類似物蛋白，以作為該多功能鑲嵌造血素受體促效劑之組成份。 WO 92/04455揭示多種融合蛋白，其係由與選自IL-3、 IL-6、IL-7、IL-9、IL-11、ΕΡΟ 及 G-CSF之淋巴因子融合之 IL-3構成。 W0 95/21197及W0 95/21254揭示多種融合蛋白，其具有廣泛之多功能造血特性。 GB 2,285,446係關於c-mpl配位體（血小板生成素）及各種形式之血小板生成素，其已證實可影響巨核細胞及巨核細胞組細胞（其可用於治療血小板減少症）之複製、分化、及成熟。 EP 675,201 A1係關於c-mpl配位體（巨核細胞生長及發展因子（MGDF))、c-mpl配位體之等位變體、及黏附於水可溶性聚合物（諸如，聚乙二醇）上之c-mpl配位體。 WO 95/21920提供鼠及人類c-mpl配位體，及其多肽片段。該等蛋白可用於進行刺激血小板生成之活體内及活體外治療。美國專利No. 4,7〇3,〇〇8 (Lin，F-K)揭示編碼紅血球生成素之cDNA序列，紅血球生成素之製備方法及用途。

O:\92\92747.DOC 200413407 WO 91/05867揭示人類紅血球生成素之類似物，其較人類紅血球生成素具有較多之峡水化合物黏附位點’諸如，EPO (Asn69)、EPO (Asn125, Ser127)、EPO (Thr125)、及EPO (pro124, Thr125)。 WO 94/24 1 60揭示具有較佳活性之紅血球生成素突變體，特別是在第 20、49、73、140、143、146、147、及 154 位具有胺基酸取代者。 WO 94/28391揭示天然flt3配位體之蛋白序列及編碼該 flt3配位體之cDNA序列，在經該cDNA轉染支宿主細胞中表現flt3配位體之方法，以及使用flt3配位體治療患有造血疾病之病患之方法。美國專利No. 5,554,5 12係關於分離蛋白形式之人類fit3 配位體，編碼該flt3配位體之DNA，經編碼flt3配位體之 cDNA轉染之宿主細胞，以及以flt3配位體治療病患之方法。 WO 94/26891提供哺乳動物nt3配位體，包括一種具有29 胺基酸插入序列之分離物，以及其片段。蛋白質序列之重排在演化中’ DNA序列之重排在產生蛋白質結構及功能變異之方面’扮演著重要的角色。基因重複及外顯子改組為快速產生、笑兴提供了重要之機制，並因此為生物體提供了競爭優勢’特別是在鹼基突變率係相當低之情形下 (Doolittle，Protein Science 1:191-200，1992)。重組DNA法之發展使得研究序列轉位對蛋白質折疊、結構、及功旎之影響成為可能。用於創造新序列之方法與天

O:\92\92747.DOC 200413407 然產生兩具有胺基酸序列線性重組相關性之蛋白質對之方法相似（Cunningham，et al·，Proc. Natl. Acad. Sci. U.S.A. 76:3218-3222, 1979; Teather & Erfle，J· Bacteriol· 172:3837-3841， 1990; Schimming et al.5 Eur. J. Biochem. 204:13-19, 1992; Yamiuchi and Minamikawa, FEBS Lett. 260:127-310, 1991;

MacGregor et al., FEBS Lett. 378:263-266)。此種類型蛋白質重排之首次活體外應用即述於Goldenberg and Creighton (J. Mol. Biol. 1665:407-413, 1983)。其於原始序列之一内部位點（斷裂點）選擇新N-端，自斷裂點至位於或接近原始C-端之一胺基酸為止，新序列皆具有與原始序列相同之胺基酸順序。於此位點，新序列即與位於或接近原始N-端之一胺基酸連接（其為直接連接或經由一額外之序列部分（連接子）連接），而新序列即以與原始序列相同之序列繼續延伸，直到其到達一位於或接近原始序列斷裂點N-端之一胺基酸之位點為止，此一殘基即形成該鏈之新C-端。此種方法已被應用於大小介於58至462胺基酸不等之蛋白質上（Goldenberg and Creighton，J. Mol. Biol· 1665:407-413, 1983; Li & Coffino, Mol· Cell. Biol. 13:2377-2383, 1993)。其所檢驗之蛋白質已涵蓋廣大範圍之結構族群，包括主要含有 α -螺旋（間白素-4 ; Kreitman et al·，Cytokine 7:311-318, 1995) 、/3 -折疊（間白素-l;Horlicketal·，Protein Eng· 5:427-431，1992) 、或此兩種之混合（酵母磷酸核糖鄰胺基苯甲酸異構酶； Luger et ai·，Science 243:206-210, 1989)。廣泛範疇之蛋白質功能亦已為此等序列重組研究涵蓋： O:\92\92747.DOC -10- 200413407 酶 T4溶菌酶 Zang et al.? Biochemistry 32:12311-12318, 1993; Zhang et al.? Nature Struct. Biol. 1:434-438, 1995 二氫葉酸還原酶 Buchwalder et al., Biochemistry 31:1621-1630, 1994; Protasova et al·，Prot· Eng· 7:1373-1377, 1995 核糖核酸酶T1 Mullins et al.? J. Am. Chem. Soc. 116:5529-5533, 1994; Garrett et al.? Protein Science 5:204-211，1966 芽胞桿菌 Hahn et al.? Proc. Natl. Acad. Sci. U.S.A. /3 -葡聚糖酶 91:10417-10421，1994 天冬胺酸 Yang & Schachman, Proc. Natl. Acad. Sci. 轉胺甲醯酶 U.S.A. 90:11980-11984, 1993 磷酸核糖鄰胺基 Luger et al.，Science 243:206-210, 1989; 苯甲酸異構酶 Lunger et al.? Prot. Eng. 3:249-258, 1990 胃蛋白酶/ Lin et al.5 Protein Science 4:159-166, 1995 胃蛋白酶原甘油醛-3 -構酸脫氫酶 Vignais et al.，Protein Science 4:994-1000, 1995 O:\92\92747.DOC -11 - 200413407

鳥胺酸脫羧酶酵母磷酸甘油酸脫氫酶酶抑制劑驗性胰蛋白酶抑制劑細胞因子間白素-1 b 間白素-4 酪胺酸激酶辨識域 α -血影蛋白SH3域跨膜蛋白 omp A 镶後蛋白間白素-4-彳叚單胞菌外毒素 O:\92\92747.DOC

Li & Coffino, Mol. Cell. Biol. 13:2377-2383, 1993

Ritco-Vonsovici et al.5 Biochemistry 34:16543-16551，1995

Goldenberg & Creighton, J. Mol. Biol. 165:407-413, 1983

Horlick et al.，Protein Eng. 5:427-431，1992 Kreitman et al.? Cytokine 7:311-318, 1995

Viguera et al.，J. Mol. Biol. 247:670-681，1995

Koebnik & Kramer, J. Mol. Biol. 250:617-626, 1995

Kreitman et al.? Proc. Natl. Acad. Sci. U.S.A. 91:6889-6893, 1994 -12- 200413407 研究之結果具有高度差異。在許多情形中，其觀察，頌讀低之活性、料度、或熱動力較性（大腸桿菌二氫葉鲛延原酶、甘油醛·3_磷酸脫氳酶、鳥胺酸脫羧酶、。— A、酵母磷酸甘油酸脫氫酶）。在其他情形中，序列重排之蛋白顯示具有與其天然形式蛋白幾乎相同之特性(驗性胰蛋白酶抑制劑、T4溶菌酶、核糖核酸酶丁1、葡聚糖酶、一、…蛋白叫胃蛋白：/: 間白素-4)。在例外之情形巾，其觀察到天然序列部分性質之意外改良，例如，重排之α—血影蛋白SH3域序列之溶解度及重折疊速率，以及轉座之間白素_4_假單胞菌外毒素融合蛋白心觉體親和力及抗腫瘤活性（Kreitman et ai.，p⑺C.

Natl. Acad. Sci. U.S.A. 91:6889-6893, 1994; Kreitman et al., Cancer Res· 55:3357-3363，1995)。此等類型研究之初始動機係研究近程及遠程之相互作用在蛋白質之折疊及安定性中所扮演的角色。此種類型之序列重排可將一組在原始序列中屬於遠程之交互作用轉化成為新序列中之近程交互作用’且可進行相反之轉化。許多此等序列重排皆可取得具有至少部分活性之構形的事實，可以作為說服性之證據，證實蛋白質折疊係由多重折疊途徑完成（Viguera et al.，J. Mol. Biol· 247:670-681, 1995)。就 α -血影蛋白SH3域之情形而言，在對應於万_髮夾結構轉角之位置選擇新終端，產生了具有稍微較低穩定性之蛋白，但其卻仍然可以折疊。咸發現用於本文所述諸等研死中之内部斷裂點位置皆全 O:\92\92747.DOC -13 - 200413407 部位於蛋白質表面，且其分布於整段線性序列中，無任何明顯偏向終端或中心之傾向（由原始端至斷裂點之相對距離之變化，經計算為總序列長度之10至80%)。於此等研究中連接原始N-及C -端之連接子具有介於〇至9不等之殘基。在其中之一項研究中（Yang & Schachman，Proc. Natl. Acad. Sci. U.S.A. 90:1 1980-1 1984, 1993)，其將一部分之序列由原始c-端部分刪除，且其係將經截短之C-端與原始Ν· 端連接。柔性親水殘基（諸如，G1y及Ser)經常被用於該等連接子中。Viguera et al. (J. Mol· Biol· 247:670-681，1995)冒比較以3-或4-殘基之連接子連結原始N-及C-端之情形·，該 3-殘基之連接子具有較低之熱動力穩定性；1^01^0^^^“· (Prot. Eng. 7:1373-13 77, 1995)使用3-及5殘基之連接子連結大腸桿菌二氫葉酸還原酶之原始N-端；僅有該3 -殘基之連接子可以良好產率產生蛋白。【發明内容】一種造血蛋白，其包含：下式之胺基酸序列：其中R!及R2分別係選自： (I) 一種人類EPO受體促效劑多肽，其包含下式之經修飾 EPO胺基酸序歹,J : A 丄 aProProArglveuIleCysAspSerArgValLeuGluArgTyirLeuLeuGluALaLys 10 20

GltiAlaGluAsnlleThrThrGlyCysAlaGluHisCysSerLeuAsnGluAsnlleThr 30 40

VaLlProAspThxXysVaiAsnPheTyrAlaTrpLysArgMetGluValGJlyO 丄 nGlnAla 50 60

O:\92\92747.DOC -14- 200413407

ValGluValTrpGlnGlyLeuAlalieuLeuSerGluAlaValLeuAr^GlyGlnAlaLeu 70 80

LeuValAsnSerSerGlnProTrpGluProLeuGlnLeuHisValAspLysAlaValSer 90 100 110 120

ProProAspAlaAlaSerAlaAlaProLeTaArgThrlleThrAlaAspThrPheArgLys 130 140

LeuPheArgValTyrSerAsnPheLeuArgGlyLysLeuLysLeuTyrThrGlyGluAla 150 160

CysArgThrGlyAspArg $EQ ID NO:4M 166 序列編號N O ·· 4 6 4 其中選擇性自N-端起之1-6胺基酸及自C-端起之1-5胺基酸可自該EPO受體促效劑多肽刪除；其中N-端係直接或經由一連接子（L2)而與C-端連結，該連接子可連接N-端及C-端，且具有分別位於下列胺基酸之新 C-及N-端； 109- 110 110- 111 111-112 112- 113 113- 114 114- 115 115- 116 116- 117 117- 118

23 - 24 47 - 48 24 - 25 48 - 49 25 - 26 49 - 50 26 - 27 50 - 51 27 - 28 5 1 - 52 28 - 29 52 - 53 29 - 30 53 - 54 30 - 3 1 54 - 55 3 1 - 32 55 - 56 O:\92\92747.DOC -15 - 200413407 32 · -33 56 - 57 118-119 33 -34 57 - 58 119-120 34 -35 77 - 78 120-121 35 -36 78 - 79 121-122 36 -37 79 - 80 122 - 123 37 -38 80 - 81 123-124 38 -39 81 - 82 124-125 39 -40 82 - 83 125-126 40 -41 84 - 85 126-127 41 -42 85 - 86 127-128 42 -43 86 - 87 128-129 43 -44 87 - 88 129-130 44 -45 88 - 89 130-131 45 -46 108 -109 131-132 46 - 47 ;及 (Π) 一種人類幹細胞因子受體促效劑多肽’其包含下式之經修飾幹細胞因子胺基酸序列：

GluGlylleCysArgAsnArgValThrAsnAsnValLysAspYalThrLysLeuValAlA 10 20 30 40

SerHisCysTrpneSerGluMetValValGlnLGuSerAspSerLeuThrAapLeuLeu 50 60

O:\92\92747.DOC -16 - 200413407

AspLysPheSerAsnlleSerGluGlyLeuSerAsnTyrSerllelleAspLysLeuVal

70 flO

Asnl 1 eVa 1 AspAspLeuVa iG luCys Va 1 L»y sG luAsnS erSerLiys AspLeuLy s 90 100

SerPheLysSerProGluProArgLeuPheThrProGluGluPhftPheArgllePheAsn 110 120

ArgSex 工 1 βΑερΑ!Ι^ΡΐΐθΙ·γ3Α3ρΡΐιβνβ 1 Val AlaS erG luThr SexrAspCysVa 1 Va i 130 140

SerSerThrLeuSerProGluLysAspSerArgValSerValThrLysProPheMetLeu 150 160

ProProValAlaAla SSQ ID NO:465 165 序列編號NO: 465 其中1 -23胺基酸可選擇性自該幹細胞因子受體促效劑多肽之C-端刪除；其中N-端係直接或經由一連接子（L2)而與C-端連結，該連接子可連接N-端及C-端，且具有分別位於下列胺基酸之新 C-及N-端； 23 - 24 39 - 40 96 - 97 24-25 40-41 97 - 98 25-26 64 - 65 98 - 99 26 - 27 65-66 99 - 100 27 - 28 66-67 100 -101 28 - 29 67-68 101 -102 29-30 68-69 102 -103 30-31 69 - 70 103 -104 31-32 70 - 71 104 -105 32 - 33 89-90 105 -106 O:\92\92747.DOC -17- 200413407 33 -34 90 -91 106 - 107 34 -35 91 -92 107 - 108 35 -36 92 -93 108 - 109 36 -37 93 -94 109 - 110 37 -38 94 -95 110 - 111 38 -39 95 -96 ；及 (ΙΠ) 一種人類flt-3受體促效劑多飾flt-3配位體胺基酸序列： T'hrGlnAspCysSerPheGlnHisS«tfPir〇ileSerSei：A«pPheAlaValLysXleArg 10 20 3luLeuSerA3pTyrLeuLeuGlnA.spTyrProValThrValAlaSerAsnLeuGlnAsp 30 40 50 60 υγ*3ΤΗι：ν9>1Α1&αΐ·ν·δβχ：1^ν3Μβΐαΐη01γΙιβ\ιΙ»βυΛΐαΑ：ζΓςινΛΐΑ3αΤΐΐΓ·σΐυΙ1©Ηί3

70 8Q Ρΐΐθνα1Τ1ΐ3Τΐ^β〇γ3ΑΐΑΡΐΐ€〇1ηΡ3Γς?Ρι:οΡΐΓ〇5βιτ€γ·5ΐ〇β\ΛΑΓ9Ρΐΐθν3·1〇1ηΤ1ιχ·Α·3η 90 100 11 eSer AirgLeu 乙 euG InGl uThrSerG lAiGlnLeuVal AlaLeuLy 3 ProTrpI 1 eThx

110 12Q Ρΐ3ΓςΓα1ηΑ$ηΡΗ&3βι:Αι：3€γ3ΐ^βιΐ01αΙ^βυ〇!ΐηζ：νρ3σ>ΙηιΡ:τοΑ3ρ5βΐ:5^ΓΤΐ·ιΐΓΐαβΐΛ 130 SEQ ID NO:466 序列編號NO: 466 其中卜7胺基酸可選擇性自該flt-3受體促效劑多肽之C-端刪除；其中N-端係直接或經由一連接子（L2)而與C-端連結’該連接子可連接N-端及C-端，且具有分別位於下列胺基酸之新 C-及N-端； 0-\92\92747.DOC -18- 200413407 28 29 30 31 32 34 36 37 38 39 40 41 序 -29 42 -43 93-94 -30 64 -65 94 - 95 -31 65 -66 95-96 -32 66 -67 96 - 97 -33 86 -87 97-98 -35 87 -88 98 - 99 -37 88 -89 99 - 100 -38 89 -90 100-101 -39 90 -91 101-102 -40 91 -92 102-103 -41 92 -93

-42 ;及 (IV) —種多肽，其包含下式之經修飾人類胺基酸列： 1 '10 Xaa Xaa Xaa Gly Pro Ala Ser Leu Pro Gin Ser Xaa 20 Leu Leu Xaa Xaa Xaa Glu Gin Val Xaa Lys Xaa Gin Gly Xaa Gly

30 40 Ala Xaa Leu Gin Glu Xaa Leu Xaa Ala Thr Tyr Ly$ Leu Xaa Xa.a 50 Xaa Glu Xaa Xaa Vai Xaa Xaa Giy His Ser Xaa Gly lie Pro Trp 60 70 Ala Pro Leu Ser Ser Xaa Pro Ser Xaa Ala Leu Xaa Leu Ala Gly 80 X^a Leu Ser Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu 90 100 -19-

O:\92\92747.DOC 200413407

Leu Gin Ala Leu Glu Gly lie Ser Pro Glu Leu Gly Pro Thr Leu 110

Xaa Thr Leu Gin Xaa Asp Val Ala Asp Phe Ala Xaa Thr 工le Trp 120 130

Gin Gin Met Glu Xaa Xaa Gly Met Ala Pro Ala Leu Gin Pro Thr 140

Gin Gly Ala Met Pro Ala Phe Ala Sex Ala Xaa Gin Xaa Xaa Ala 150 160

Gly Gly Val U&u Val Ala Ser Xaa Leu G.ln Xaa Phe Lea Xaa Xaa 170 Λ

Ser Tyr Arg Val Leu Xaa Xaa Leu Ala Gin Pro seq id no： 85 8 序列編號NO: 858 其中第 1位之 Xaa係 Thr、Ser、Arg、Tyr或 Gly ; 第2位之Xaa係Pro或Leu ; 第 3位之 Xaa係 Leu、Arg、Tyr或 Ser ; 第 13 位之 Xaa 係 Phe、Ser、His、Thr 或 Pro ; 第 16位之 Xaa係 Lys、Pro、Ser、Thr或 His ; 第 17位之 Xaa係 Cys、Ser、Gly、Ala、lie、Tyr 或 Arg 第 18位之 Xaa係 Leu、Thr、Pro、His、lie或 Cys ; 第 22位之 Xaa係 Arg、Tyr、Ser、Thr或 Ala ; 第 24位之 Xaa係 lie、Pro、Tyr 或 Leu ; 第27位之Xaa係Asp或Gly ; 第 3 0位之 Xaa係 Ala、lie、Leu或 Gly ; 第34位之Xaa係Lys或Ser ; 第36位之Xaa係Cys或Ser ; 第42位之Xaa係Cys或Ser ; 20-

O:\92\92747.DOC 200413407 第 43位之 Xaa係 His、Thr、Gly、Val、Lys、Trp、Ala、Arg 、Cys或 Leu ; 第 44位之 Xaa係 Pro、Gly、Arg、Asp、Val、Ala、His、Trp 、Gin或 Thr ; 第 46位之 Xaa係 Glu、Arg、Phe、Arg、lie或 Ala ; 第47位之Xaa係Leu或Thr ; 第 49位之 Xaa係 Leu、Phe、Arg或 Ser ;

第 5 0位之 Xaa係 Leu、lie、His、Pro或 Tyr ; 第54位之Xaa係Leu或His ; 第64位之Xaa係Cys或Ser ; 第 67位之 Xaa係 Gin、Lys、Leu或 Cys ; 第 70位之 Xaa係 Gin、Pro、Leu、Arg或 Ser ; 第74位之Xaa係Cys或Ser ; 第 104 位之 Xaa 係 Asp、Gly 或 Val ;

第 108位之 Xaa係 Leu、Ala、Val、Arg、Trp、Gin或 Gly ; 第 115位之 Xaa係 Thr、His、Leu或 Ala ; 第 120位之 Xaa係 Gin、Gly、Arg、Lys 或 His ; 第 123 位之 Xaa 係 Glu、Arg、Phe 或 Thr ; 第 144位之 Xaa係 Phe、His、Arg、Pro、Leu、Gin或 Glu ; 第146位之Xaa係Arg或Gin ; 第147位之Xaa係Arg或Gin ; 第 156 位之 Xaa 係 His、Gly 或 Ser ; 第 1 59位之 Xaa係 Ser、Arg、Thr、Tyr、Val或 Gly ; 第 162位之 Xaa係 Glu、Leu、Gly 或 Trp ; O:\92\92747.DOC -21 - 200413407 第 163 位之 Xaa 係 Val、Gly、Arg 或 Ala ; 第 169位之 Xaa係 Arg、Ser、Leu、Arg或 Cys ; 第 170 位之 Xaa 係 His、Arg 或 Ser ; 其中選擇性自N-端起之1-11胺基酸及自C -端起之i 酸可自該經修飾之人類G-CSF胺基酸序列刪除；其中N-端係直接或經由一連接子（l2)而與匕端連結接子可連接N-端 •a广上山 C-及N-端； 38 - 39 62 - 63 39 - 40 63 - 64 40 - 41 64 - 65 41 - 42 65 - 66 42 - 43 66 - 67 43 - 44 67 - 68 45 - 46 68 - 69 48 - 49 69 - 70 49 - 50 70 - 71 52 - 53 71 - 72 53 - 54 91 - 92 54 - 55 92 - 93 55 - 56 93 - 94 56 - 57 94 - 95 57 - 58 95 - 96 58 - 59 96 - 97 4胺基，該連酸之新且具有分別位於下列胺基 123 - 124 124 - 125 125- 126 126- 127 128 - 129 128- 129 129- 130 130- 131 131- 132 132- 133 133- 134 134- 135 135- 136 136- 137 137 - 138 138-139 O:\92\92747.DOC -22- 200413407 59 - 60 97 - 98 139 - 140 6〇 - 61 98 - 99 140 - 141 61 - 62 99-100 141-142 或 142 - 143 ; (V) —種多肽，其包含下式之經修飾人類IL_3胺基酸序列·

Ala Pro Met Thr Gin Thr Thr Ser Leu Lys Thr Ser Trp Val Asn 1 5 10 15

Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 20 25 30

Xaa Xaa Xasi Xaa Xaa iCeia· Xaa Asn X在a Xaa Xaa Xaa Xaa Xaa 35 40 v 45

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 50 55 60

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 65 70 7 5»

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa. Xaa 80 85 90

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xa« Xaa Xa.«t Xaa Xaa 95 100 105

Xa〇L Phe Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 110 115 120

Xaa Xaa Xaa Gin Gin Thr Thr Leu Ser Leu Ala lie Phe SEQ 10 ίίΟ:Β5ζ 125 X30 序列編號NO: 859 其中第 17位之Xaa係 Ser、Lys、Gly、Asp、Met、Gin或 Arg 第 18 位之 Xaa 係 Asn、His、Leu、lie、Phe、Arg 或 Gin ; 第 19位之 Xaa係 Met、Phe、lie、Arg、Gly、Ala或 Cys ;

O:\92\92747.DOC -23 - 200413407 第 20位之 Xaa係 lie、Cys、Gin、Glu、Arg、Pro 或 Ala ; 第 21 位之 Xaa係 Asp、Phe、Lys、Arg、Ala、Gly、Glu、Gin 、Asn、Thr、Ser或 Val ; 、Gin、Leu、Val或 Gly ; 第 23位之 Xaa係 lie、Val、Ala、Gly、Trp、Lys、Phe、Leu 、Ser或 Arg ;

第 24 位之 Xaa係 lie、Gly、Val、Arg、Ser、Phe 或 Leu ; 第 25 位之 Xaa 係 Thr、His、Gly、Gin、Arg、Pro 或 Ala ; 第 26位之 Xaa係 His、Thr、Phe、Gly、Arg、Ala或 Trp ; 第 27位之 Xaa係 Leu、Gly、Arg、Thr、Ser或 Ala ; 第 28位之Xaa係 Lys、Arg、Leu、Gin、Gly、Pro、Val或 Trp ; 第 29位之 Xaa係 Gin、Asn、Leu、Pro、Arg或 Val ; 第 3 0位之 Xaa 係 Pro、His、Thr、Gly、Asp、Gin、Ser、Leu 或 Lys ;

第 3 1 位之 Xaa係 Pro、Asp、Gly、Ala、Arg、Leu或 Gin ; 第 32位之Xaa係 Leu、Val、Arg、Gin、Asn、Gly、Ala或Glu ; 第 3 3位之 Xaa係 Pro、Leu、Gin、Ala、Thr 或 Glu ; 第 34位之 Xaa係 Leu、Val、Gly、Ser、Lys、Glu、Gin、Thr 、Arg、Ala、Phe、lie或 Met ; 第 35位之 Xaa係 Leu、Ala、Gly、Asn、Pro、Gin或 Val ; 第 3 6位之 Xaa係 Asp、Leu或 Val ; 第 37位之 Xaa係 Phe、Ser、Pro、Trp或 lie ; 第38位之Xaa係Asn或Ala ; O:\92\92747.DOC -24- 200413407 第 40位之 Xaa係 Leu、Trp或 Arg ; 第 41 位之 Xaa係 Asn、Cys、Arg、Leu、His、Met或 Pro ; 第 42 位之 Xaa 係 Gly、Asp、Ser、Cys、Asn、Lys、Thr、Leu 、Val、Glu、Phe、Tyr、lie、Met或 Ala ; 第 43 位之 Xaa 係 Glu、Asn、Tyr、Leu、Phe、Asp、Ala、Cys 、Gin、Arg、Thr、Gly或 Ser ;

第 44位之 Xaa係 Asp、Ser、Leu、Arg、Lys、Thr、Met、Trp 、Glu、Asn、Gin、Ala或 Pro ; 第 45位之 Xaa係 Gin、Pro、Phe、Val、Met、Leu、Thr、Lys 、Trp、Asp、Asn、Arg、Ser、Ala、lie、Glu或 His ; 第 4 6位之 Xaa係 Asp、Phe、Ser、Thr、Cyss、Glu、Asn、Gin 、Lys、His、Ala、Tyr、lie、Val或 Gly ; 第 47 位之 Xaa 係 lie、Gly、Va 卜 Ser、Arg、Pro 或 His ; 第 4 8位之 Xaa 係 Leu、Ser、Cys、Arg、lie、His、Phe、Glu 、Lys、Thr、Ala、Met、Val或 Asn ;

第 49位之Xaa係 Met、Arg、Ala、Gly、Pro、Asn、His或 Asp ; 第 50 位之 Xaa 係 Glu、Leu、Thr、Asp、Tyr、Lys、Asn、Ser 、Ala、lie、VaU、His、Phe、Met 或 Gin ; 第 5 1 位之 Xaa係 Asn、Arg、Met、Pro、Ser、Thr或 His ; 第 52位之 Xaa係 Asn、His、Arg、Leu、Gly、Ser或 Thr ; 第 53位之 Xaa係 Leu、Thr、Ala、Gly、Glu、Pro、Lys、Ser 或 Met ; 第 5 4位之 Xaa 係 Arg、Asp、lie、Ser、Val、Thr、Gin、Asn 、Lys、His、Ala或 Leu ; O:\92\92747.DOC -25 - 200413407 第 55 位之 Xaa 係 Arg、Thr、Val：、Ser、Leu 或 Gly ; 第 56 位之 Xaa 係 Pro、Gly、Cys、Ser、Gin、Glu、Arg、His 、Thr、Ala、Tyr、Phe、Leu、Val或 Lys ; 第5 7位之Xaa係Asn或Gly ; 第 5 8位之 Xaa係 Leu、Ser、Asp、Arg、Gin、Val或 Cys ; 第59位之乂3&係01\111、丁}^、1^3、1^11、？1：〇或八^; 第 60位之 Xaa係 Ala、Ser、Pro、Tyr、Asn或 Thr ;

第 61 位之 Xaa係 Phe、Asn、Glu、Pro、Lys、Arg或 Ser ; 第 62位之Xaa係 Asn、His、Val、Arg、Pro、Thr、Asp或 lie ; 第 63位之Xaa係 Arg、Tyr、Trp、Lys、Ser、His、Pro或Val ; 第 64位之 Xaa係 Ala、Asn、Pro、Ser或 Lys ; 第 65位之 Xaa係 Va卜 Thr、Pro、His、Leu、Phe或 Ser ; 第 66位之 Xaa係 Lys、lie、Arg、Val、Asn、Glu或 Ser ; 第 67位之 Xaa係 Ser、Ala、Phe、Val、Gly、Asn、lie、Pro 或 His ;

第 68位之Xaa係 Leu、Val、Trp、Ser、lie、Phe、Thr或His ; 第 69位之 Xaa係 Gin、Ala、Pro、Thr、Glu、Arg、Trp、Gly 或 Leu ; 第 70位之 Xaa係 Asn、Leu、Val、Trp、Pro或 Ala ; 第 71 位之 Xaa係 Ala、Met、Leu、Pro、Arg、Glu、Thr、Gin 、丁rp或 Asn ; 第 72位之Xaa係 Ser、Glu、Met、Ala、His、Asn、Arg或Asp ; 第 73位之Xaa係 Ala、Glu、Asp、Leu、Ser、Gly、Thr或 Arg ; 第 74位之 Xaa係 lie、Met、Thr、Pro、Arg、Gly、Ala ; O:\92\92747.DOC -26- 200413407 第 75位之 Xaa係 Glu、Lys、Gly、Asp、Pro、Trp、Arg、Ser 、Gin或 Leu ; 第 76 位之 Xaa 係 Ser、Val、Ala、Asn、Trp、Glu、Pro、Gly 或 Asp ; 第77位之又33係116、861*、八巧、丁]11*或1^11; 第 78位之 Xaa係 Leu、Ala、Ser、Glu、Phe、Gly 或 Arg ; 第 79位之Xaa係 Lys、Thr、Asn、Met、Arg、lie、Gly或 Asp ; 第 80位之Xaa係 Asn、Trp、Va卜 Gly、Thr、Leu、Glu或 Arg ; 第 81位之Xaa係 Leu、Gin、Gly、Ala、Trp、Arg、Val或 Lys ; 第 82位之 Xaa係 Leu、Gin、Lys、Trp、Arg、Aas、Glu、Asn 、His、Thr、Ser、Ala、Tyr、Phe、lie、Met或 Val ; 第 83位之 Xaa係 Pro、Ala、Thr、Trp、Arg或 Met ; 第 84位之 Xaa係 Cys、Glu、Gly、Arg、Met或 Val ; 第 85位之 Xaa係 Leu、Asn、Val或 Gin ; 第 86位之 Xaa係 Pro、Cys、Arg、Ala或 Lys ; 第 87位之 Xaa係 Leu、Ser、Trp或 Gly ; 第 88位之 Xaa係 Ala、Lys、Arg、Val或 Trp ; 第 89位之 Xaa係 Thr、Asp、Cys、Ley、Va卜 Glu、His、Asn 或 Ser ; 第 90位之Xaa係 Ala、Pro、Ser、Thr、Gly、Asp、lie或Met ; 第 91 位之Xaa係 Ala、Pro、Ser、Thr、Phe、Leu、Asp或His ; 第 92位之 Xaa係 Pro、Phe、Arg、Ser、Lys、His、Ala、Gly 、lie或 Leu ; 第 93位之Xaa係 Thr、Asp、Ser、Asn、Pro、Ala、Leu或 Arg ; O:\92\92747.DOC -27- 200413407 第 94位之 Xaa 係 Arg、lie、Ser、Glu、Leu、Val、Gin、Lys 、His、Ala或 Pro ; 第 95位之 Xaa係 His、Gin、Pro、Arg、Val、Leu、Gly、Thr 、Asn、Lys、Ser、Ala、Trp、Phe、lie或 Tyr ·，第 96位之 Xaa係 Pro、Lys、Tyr、Gly、lie或 Thr ; 第 97位之 Xaa係 lie、Val、Lys、Ala或 Asn ; 第 98位之 Xaa 係 His、lie、Asn、Leu、Asp、Ala、Thr、Glu 、Gin、Ser、Phe、Met、Val、Lys、Arg、Tyr或 Pro ; 第 99位之 Xaa係 lie、Leu、Arg、Asp、Val、Pro、Gin、Gly 、Ser、Phe或 His ; 第 1 00位之 Xaa係 Lys、Tyr、Leu、His、Arg、lie、Ser、Gin 或 Pro ; 第 101 位之 Xaa係 Asp、Pro、Met、Lys、His、Thr、Val、Tyr 、Glu、Asn、Ser、Ala、Gly、lie、Leu或 Gin ; 第 102位之 Xaa係 Gly、Leu、Glu、Lys、Ser、Tyr或 Pro ; 第103位之Xaa係Asp或Ser ; 第 104 位之 Xaa 係 Trp、Val、Cys、Tyr、Thr、Met、Pro、Leu 、Gin、Lys、Ala、Phe或 Gly ; 第 105位之 Xaa係 Asn、Pro、Ala、Phe、Ser、Trp、Gin、Tyr 、Leu、Lys、lie、Asp或 His ·，第 106位之Xaa係 Glu、Ser、Ala、Lys、Thr、lie、Gly或Pro ; 第 108位之 Xaa係 Arg、Lys、Asp、Leu、Thr、lie、Gin、His 、Ser、Ala或 Pro ; 第 109位之Xaa係 Arg、Thr、Pro、Glu、Tyr、Leu、Ser或 Gly ; O:\92\92747.DOC -28- 200413407 第 1 1 0位之 Xaa係 Lys、Ala、Asn、Thr、Leu、Arg、Gin、 His、Glu、Ser或 Trp ; 第 11 1 位之 Xaa係 Leu、lie、Arg、Asp或 Met ; 第 112位之Xaa係 Thr、Val、Gin、Tyr、Glu、His、Ser或 Phe ; 第 11 3位之 Xaa係 Phe、Ser、Cys、His、Gly、Trp、Tyr、Asp 、Lys、Leu、lie、Val或 Asn ; 第 114位之 Xaa係 Tyr、Cys、His、Ser、Trp、Arg或 Leu ;

第 11 5位之 Xaa係 Leu、Asn、Val、Pro、Arg、Ala、His、Thr 、Trp 或 Met ; 第 116位之 Xaa係 Lys、Leu、Pro、Thr、Met、Asp、Val、 Glu、Arg、Trp、Ser、Asn、His、Ala、Tyr、Phe、Gin或lie ; 第 11 7位之 Xaa係 Thr、Ser、Asn、lie、Trp、Lys或 Pro ; 第 118位之Xaa係 Leu、Ser、Pro、Ala、Glu、Cys、Asp或 Tyr ; 第 119位之Xaa係 Glu、Ser、Lys、Pro、Leu、Thr、Tyr或 Arg ; 第 120位之 Xaa係 Asn、Ala、Pro、Leu、His、Val或 Gin ;

第 121 位之Xaa係 Ala、Ser、lie、Asn、Pro、Lys、Asp或Gly ; 第 122位之Xaa係 Gin、Ser、Met、Trp、Arg、Phe、Pro、His、 lie、Tyr或 Cys ·，第 123位之Xaa係 Ala、Met、Glu、His、Ser、Pro、Tyr或Leu ; 其中自1至14胺基酸可選擇性自該經修飾人類IL-3胺基酸序列之N-端刪除及/或自1至15胺基酸可選擇性自該經修飾人類IL-3胺基酸序列之C-端刪除；其中以Xaa表示之自0至 44胺基酸與天然（1-133)人類間白素-3之對應胺基酸不同；及其中N-端係直接或經由一連接子（L2)而與C-端連結，該連 O:\92\92747.DOC -29- 200413407 接子可連接N-端及C-端，且具有分別位於下列胺基酸之新 C-及N-端； 26 -27 49 - 50 83-84 27 -28 50 - 51 84-85 28 -29 51 - 52 85-86 29 -30 52 - 53 86-87 30 -31 53 - 54 87-88 31 -32 54 - 55 88-89 32 -33 64 - 65 89-90 33 -34 65 - 66 90-91 34 -35 66 - 67 91-92 35 -36 67 - 68 92 - 93 36 -37 68 - 69 97-98 37 -38 69 - 70 98-99 38 -39 70 - 71 100-101 39 -40 71 - 72 100-101 40 -41 72 - 73 101-102 41 -42 8Z - 83 102-103 或 103 - 104 ; (VI) —種多肽，其包含下式之經修飾人類c-mpl配位體胺基酸序列： O:\92\92747.DOC -30- 200413407 8βΓΡΐΓ〇Αΐ3ΡΓ·〇Ρΐ：〇Α1&〔γ5Α：5ρΙ^θυ^Γ9νΑΐΙ^βυΐ3〇：1：Ιιγ5ΐ1βνχ1ιβ^ΐΑ2：9Α5ρ5βΧ* 15 10 15

HisValLeuHi εΒβΓΑαΙιθυΒθΓΟίιΚ^ΡΓΟΟίιινθίΗΐδΡιτοΙ^ΐΛΡΓοΤίίΓΡΓΟ 20 25 30 3 5

ValLeuLeuProAlAValAspPh.eSerLeiiGlyGluTrpLysThrdnMet：GXuGlu 40 45 50 55

ThirliysAlaGlnAsp 工 1已1*611〇1;^1&'^3>1|1>11：^1|6111*6\114611〇111<31^^迁111«匕八1违 60 65 10 75 A laArgG lyGlriLeuGlyPr oThr cisLeuSer S Gr LeuLeuG 1 yGlnLeuSer Gly 80 85 90 95

GlnVa.1 Ar gLeuLeuL euGlyA 1 aLeuGlnS er L euLeuGlyThLrGlnXaaXaaXaa 100 105 110

XaaGlyArgTbrTtLrAlaHisLysAspProAsnAlaXlePh.eLe\jSerPh：eGlnHis 115 12 0 125 130

LeuLeuArgGlyLysValArgPheLeuMetLeuValGlyGlySerThrteUCysVal 135 140 145 150

Arg SEQ ID NO :86 0 153 序列編號NO: 860 其中；第 112位之 Xaa係經刪除或為Leu、Ala、Val、lie、Pro、Phe 、Trp或 Met ; 第 113位之 Xaa係經刪除或為Pro、Phe、Ala、Val、Leu、lie 、Trp 或 Met ; 第 114位之 Xaa係經删除或為 Pro、Phe、Ala、Val、Leu、lie 、Trp 或 Met ; 第115位之Xaa係經刪除或為Gin、Gly、Ser、Thr、Tyr或Asn ;及其中N-端係直接或經由一連接子（L2)而與端連結’該連接子可連接N-端及C-端，且具有分別位於下列胺基酸之新

O:\92\92747.DOC -31 - 200413407 C-及N-端； 26 - 27 51 - 52 27 - 28 52 - 53 28 - 29 53 - 54 29 - 30 54 - 55 30 - 31 55 - 56 32 - 33 56 - 57 33 - 34 57 - 58 34 - 35 58 - 59 36 - 37 59 - 60 37 - 38 78 - 79 38 - 39 79 - 80 40 - 41 80 - 81 41 - 42 81 - 82 42 - 43 82 - 83 43 - 44 83 - 84 44 - 45 84 - 85 46 - 47 85 - 86 47 - 48 86 - 87 48 - 49 87 - 88 50 - 51 88 - 89 (VII) —種多肽，列·· 108- 109 109- 110 110- 111 111-112 112-113 113 - 114 114 - 115 115- 116 116- 117 117 - 118 118- 119 119- 120 120- 121 121 - 122 122 - 123 123 - 124 124-125 125 - 126 126 - 127 或 127 - 128 ; 包含下式之經修飾類IL-3胺基酸序 O:\92\92747.DOC -32- 200413407

Ala Pro Met Thr Gin Thr Thr Ser Leu Lys Thr Ser Trp Val Asn 1 5 10 15

Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xa_a Xaa 20 25 30 Χάβ. Kaa Xa.a Xaa Xaa Xaa Xaa Xaa Aan Xaa Xaa Xaa Xaa Xaa Xaa 35 40 45 Χαα Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Χαα Xaa 50 55 60

Xaa Xaa >；aa Xaa Xaa Xeta Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 65 7〇、 75

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa. Xaa 80 85 90

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 95 100 105 X^a Phfe Xaa X&a Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 110 115 120

Xaa Xaa Xaa Gin Gin Thr Thr Leu Ser Leu Ala lie Phe S2Q ID N0：8f 125 130 序列編號NO: 859 其中第 17位之Xaa係 Ser、Lys、Gly、Asp、Met、Gin或 Arg ; 第 18位之Xaa係 Asn、His、Leu ’ 第 19位之 Xaa係 Met、Phe、lie、第 20位之 Xaa係 lie、Cys、Gin、第 21 位之 Xaa係 Asp、Phe、Lys、、Asn、Thr、Ser或 Val，第 22位之 Xaa係 Glu、Trp、Pro、、Gin、Leu、Val或 Gly ; 第 23 位之 Xaa係 lie、Val、Ala、 lie、Phe、Arg或 Gin ; Arg、Gly、Ala或 Cys ; Glu、Arg、Pro或 Ala ; Arg、Ala、Gly、Glu、Gin Ser、Ala、His、Asp、Asn Gly、Trp、Lys、Phe、Leu 勹Λ -JJ -

O:\92\92747.DOC 200413407 、Ser或 Arg ; 第 24位之 Xaa係 lie、Gly、Val、Arg、Ser、Phe或 Leu ; 第 25位之 Xaa係 Thr、His、Gly、Gin、Arg、Pro或 Ala ; 第26位之又33係出3、丁111'、？]16、017、八巧、八13或1>卩；第 27位之 Xaa係 Leu、Gly、Arg、Thr、Ser或 Ala ; 第 28位之Xaa係 Lys、Arg、Leu、Gin、Gly、Pro、Val或 Trp ; 第 29位之 Xaa係 Gin、Asn、Leu、Pro、Arg或 Val ;

第 30 位之 Xaa 係 Pro、His、Thr、Gly、Asp、Gin、Ser、Leu 或 Ly s ; 第 3 1 位之 Xaa係 Pro、Asp、Gly、Ala、Arg、Leu或 Gin ; 第 32位之Xaa係 Leu、Val、Arg、Gin、Asn、Gly、Ala或 Glu ; 第 33位之 Xaa係 Pro、Leu、Gin、Ala、Thr或 Glu ; 第 34位之 Xaa係 Leu、Va卜 Gly、Ser、Lys、Glu、Gin、Thr 、Arg、Ala、Phe、lie或 Met ; 第 3 5位之 Xaa係 Leu、Ala、Gly、Asn、Pro、Gin或 Val ;

第 3 6位之 Xaa係 Asp、Leu或 Val ; 第 3 7位之 Xaa係 Phe、Ser、Pro、Trp或 lie ; 第38位之Xaa係Asn或Ala ; 第 40位之 Xaa係 Leu、Trp 或 Arg ; 第 41 位之 Xaa係 Asn、Cys、Arg、Leu、His、Met或 Pro ; 第 42位之 Xaa係 Gly、Asp、Ser、Cys、Asn、Lys、Thr、Leu 、Val、Glu、Phe、Tyr、lie、Met或 Ala ; 第 43 位之 Xaa 係 Glu、Asn、Tyr、Leu、Phe、Asp、Ala、Cys 、Gin、Arg、Thr、Gly或 Ser ; O:\92\92747.DOC -34- 200413407 第 44位之 Xaa係 Asp、Ser、Leu、Arg、Lys、Thr、Met、Trp 、Glu、Asn、Gin、Ala或 Pro ; 第 45 位之 Xaa 係 Gin、Pro、Phe、Val、Met、Leu、Thr、Lys 、Trp、Asp、Asn、Arg、Ser、Ala、lie、Glu或 His ; 第46位之又&&係八3卩、卩116、861*、丁]11'、0}^、〇111、八311、〇111 、Lys、His、Ala、Tyr、lie、Val或 Gly ; 第 47 位之 Xaa 係 lie、Gly、Va 卜 Ser、Arg、Pro 或 His ;

第 48 位之 Xaa 係 Leu、Ser、Cys、Arg、lie、His、Phe、Glu 、Lys、Thr、Ala、Met、Val或 Asn ; 第 49位之Xaa係 Met、Arg、Ala、Gly、Pro、Asn、His或 Asp ; 第 50位之 Xaa係 Glu、Leu、Thr、Asp、Tyr、Lys、Asn、Ser 、Ala、lie、Val、His、Phe、Met或 Gin ; 第 5 1 位之 Xaa係 Asn、Arg、Met、Pro、Ser、Thr 或 His ; 第 52位之 Xaa係 Asn、His、Arg、Leu、Gly、Ser或 Thr ;

第 53 位之 Xaa 係 Leu、Thr、Ala、Gly、Glu、Pro、Lys、Ser 或 Met ; 第 54位之 Xaa係 Arg、Asp、lie、Ser、Val、Thr、Gin、Asn 、Lys、His、Ala或 Leu ; 第 55位之 Xaa係 Arg、Thr、Va卜 Ser、Leu或 Gly ; 第 56位之 Xaa係 Pro、Gly、Cys、Ser、Gin、Glu、Arg、His 、Thr、Ala、Tyr、Phe、Leu、Val或 Lys ; 第5 7位之Xaa係Asn或Gly ; 第 5 8位之 Xaa係 Leu、Ser、Asp、Arg、Gin、Val或 Cys ; 第 59位之 Xaa係 Glu、Tyr、His、Leu、Pro或 Arg ; O:\92\92747.DOC -35- 200413407 第 60位之 Xaa係 Ala、Ser、Pro、Tyr、Asn或 Thr ; 第 61 位之 Xaa係 Phe、Asn、Glu、Pro、Lys、Arg或 Ser ; 第 62位之Xaa係 Asn、His、Val、Arg、Pro、Thr、Asp或 lie ; 第 63位之Xaa係 Arg、Tyr、Trp、Lys、Ser、His、Pro或 Val ; 第 64位之 Xaa係 Ala、Asn、Pro、Ser或 Lys ; 第 65位之 Xaa係 Val、Thr、Pro、His、Leu、Phe或 Ser ; 第 66位之 Xaa係 Lys、lie、Arg、Val、Asn、Glu或 Ser ;

第 67位之 Xaa係 Ser、Ala、Phe、Val、Gly、Asn、lie、Pro 或 His ; 第 68位之Xaa係Leu、Va卜 Trp、Ser、lie、Phe、Thr或His ; 第 69位之 Xaa係 Gin、Ala、Pro、Thr、Glu、Arg、Trp、Gly 或 Leu ; 第 70位之 Xaa係 Asn、Leu、Val、Trp、Pro或 Ala ; 第 71 位之 Xaa係 Ala、Met、Leu、Pro、Arg、Glu、Thr、Gin 、Trp或 Asn ;

第 72位之Xaa係 Ser、Glu、Met、Ala、His、Asn、Arg或 Asp ; 第 73位之Xaa係 Ala、Glu、Asp、Leu、Ser、Gly、Thr或 Arg ; 第 74位之 Xaa係 lie、Met、Thr、Pro、Arg、Gly、Ala ; 第 75位之 Xaa係 Glu、Lys、Gly、Asp、Pro、Trp、Arg、Ser 、Gin或 Leu ; 第 76位之 Xaa係 Ser、Val、Ala、Asn、Trp、Glu、Pro、Gly 或 Asp ; 第 77 位之 Xaa 係 lie、Ser、Arg、Thr 或 Leu ; 第 78位之 Xaa係 Leu、Ala、Ser、Glu、Phe、Gly 或 Arg ; O:\92\92747.DOC -36- 200413407 第 79位之Xaa係 Lys、Thr、Asn、Met、Arg、lie、Gly或 Asp ; 第 80位之Xaa係 Asn ' Trp、Va卜 Gly、Thr、Leu、Glu或 Arg ; 第 81 位之Xaa係Leu、Gin、Gly、Ala、Trp、Arg、Val或Lys ; 第 82位之 Xaa係 Leu、Gin、Lys、Trp、Arg、Aas、Glu、Asn 、His、Thr、Ser、Ala、Tyr、Phe、lie、Met或 Val ; 第 83位之 Xaa係 Pro、Ala、Thr、Trp、Arg或 Met ; 第 84位之 Xaa係 Cys、Glu、Gly、Arg、Met或 Val ; 第 85位之 Xaa係 Leu、Asn、Val或 Gin ; 第 86位之 Xaa係 Pro、Cys、Arg、Ala或 Lys ; 第 87位之 Xaa係 Leu、Ser、Trp或 Gly ; 第 88位之 Xaa係 Ala、Lys、Arg、Val或 Trp ; 第 89位之 Xaa係 Thr、Asp、Cys、Ley、Val、Glu、His、Asn 或 Ser ·，第 90位之Xaa係 Ala、Pro、Ser、Thr、Gly、Asp、lie或Met ; 第 91位之Xaa係 Ala、Pro、Ser、Thr、Phe、Leu、Asp或 His ; 第 92位之 Xaa係 Pro、Phe、Arg、Ser、Lys、His、Ala、Gly 、lie或 Leu ; 第 93位之Xaa係 Thr、Asp、Ser、Asn、Pro、Ala、Leu或 Arg ; 第 94 位之 Xaa 係 Arg、lie、Ser、Glu、Leu、Val、Gin、Lys 、His、Ala或 Pro ; 第 95位之 Xaa係 His、Gin、Pro、Arg、Val、Leu、Gly、Thr 、Asn、Lys、Ser、Ala、Trp、Phe、lie或 Tyr ; 第 96位之 Xaa係 Pro、Lys、Tyr、Gly、lie或 Thr ; 第 97 位之 Xaa 係 lie、Val、Lys、Ala 或 Asn ; O:\92\92747.DOC -37- 200413407 第 98位之 Xaa係 His、lie、Asn、Leu、Asp、Ala、Thr、Glu 、Gin、Ser、Phe、Met、Val、Lys、Arg、Tyr或 Pro ; 第 99位之 Xaa係 lie、Leu、Arg、Asp、Val、Pro、Gin、Gly 、Ser、Phe或 His ; 第 1 00位之 Xaa係 Lys、Tyr、Leu、His、Arg、lie、Ser、Gin 或 Pro ; 第 10 1 位之 Xaa係 Asp、Pro、Met、Lys、His、Thr、Val、Tyr 、Glu、Asn、Ser、Ala、Gly、lie、Leu或 Gin ; · 第 102位之 Xaa係 Gly、Leu、Glu、Lys、Ser、Tyr或 Pro ; 第103位之Xaa係Asp或Ser ; 第 1 04位之 Xaa係 Trp、Val、Cys、Tyr、Thr、Met、Pro、Leu 、Gin、Lys、Ala、Phe或 Gly ; 第 105位之 Xaa係 Asn、Pro、Ala、Phe、Ser、Trp、Gin、Tyr 、Leu、Lys、lie、Asp或 His ; 第 106位之Xaa係 Glu、Ser、Ala、Lys、Thr、lie、Gly或 Pro ; 第 108位之 Xaa係 Arg、Lys、Asp、Leu、Thr、lie、Gin、His _ 、Ser、Ala或 Pro ; 第 109位之Xaa係 Arg、Thr、Pro、Glu、Tyr、Leu、Ser或 Gly ; 第 110位之 Xaa係 Lys、Ala、Asn、Thr、Leu、Arg ' Gin、

His、Glu、Ser或 Trp ; 第 111位之 Xaa 係 Leu、lie、Arg、Asp 或 Met ; 第 112位之Xaa係 Thr、Va卜 Gin、Tyr、Glu、His、Ser或Phe ; 第 113位之 Xaa係 Phe、Ser、Cys、His、Gly、Trp、Tyr、Asp 、Lys、Leu、lie、Val或 Asn ; O:\92\92747.DOC -38- 200413407 第 114位之 Xaa係 Tyr、Cys、His、Ser、Trp、Arg或 Leu ; 第 115 位之 Xaa 係 Leu、Asn、Val、Pro、Arg、Ala、His、Thr 、Trp 或 Met ; 第 116位之 Xaa係 Lys、Leu、Pro、Thr、Met、Asp、Val、

Glu、Arg、Trp、Ser、Asn、His、Ala、丁yr、Phe、Gin或lie ; 第 117位之 Xaa係 Thr、Ser、Asn、lie、Trp、Lys或 Pro ; 第 118位之Xaa係Leu、Ser、Pro、Ala、Glu、Cys、Asp或Tyr ; 第 119位之Xaa係 Glu、Ser、Lys、Pro、Leu、Thr、Tyr或 Arg ; _ 第 120位之 Xaa係 Asn、Ala、Pro、Leu、His、Val或 Gin ; 第 121 位之Xaa係 Ala、Ser、Ille、Asn、Pro、Lys、Asp或Gly ; 第 122 位之 Xaa 係 Gin、Ser、Met、Trp、Arg、Phe、Pro、His 、lie、Tyr或 Cys ; 第 123位之Xaa係 Ala、Met、Glu、His、Ser、Pro、Tyr或Leu ; 其中自1至14胺基酸可選擇性自該經修飾人類IL-3胺基酸序列之N-端刪除及/或自1至15胺基酸可選擇性自該經修飾人類IL-3胺基酸序列之C-端刪除；其中以Xaa表示之自1至 φ 44胺基酸與天然（1-133)人類間白素-3之對應胺基酸不同；及 (VIII) 一種因子，其選自：集落刺激因子、細胞因子、淋巴因子、間白素；且其中Li係可連接^及R2之連接子；其限制條件為至少心或112係選自式（I)、（II)或（III)之多肽 ;且該造血蛋白之前端可選擇性毗鄰（甲硫胺酸-1)、（丙胺酸-1) 或（甲硫胺酸Λ丙胺酸，。 O:\92\92747.DOC -39- 200413407 在上述多肽⑴中可產生新C-端及N-端之較佳斷裂點為； 23_24、24-25、25-26、27-28、28_29、29_30、30-3 卜 31_32 、32_3 3、33-34、34_35、3 5_36、36_3 7、37_38、3 8-39、40-41 、41-42、42_43、5 2_53、53_54、54_55、5 5_56、77_78、78_79 ' 79-80、80-81、81一82、82-83、83-84、84-85、85-86、86-87 > 109-110' 110-1 1 1 > 11〇-1 11 ^ 111-112^ 112-113^ 113-114 、114-115、115-116、116-117、117_118、118-119、119-120 、120-121、121-122、122_123、123-124、124-125、125-126、φ 126-127、127-128、128-129、129-130、130-131、及 131-132。在上述多肽（I)中可產生新C_端及端之最佳斷裂點為； 23-24、24-25、31-32、32-33、37-38、38-39、82-83、83-84 、85-86、86-87、87-88、125-126、126-127、及 131-132。本發明之EPO受體促效劑可含有胺基酸取代（諸如揭示方、WO 94024160者’或是一或多位於 Asn24、Asn83 及 Asnl26 之糖基化^點改變為其他胺基酸，例如，但不限於，Asp 或Glu)缺失及/或插入。亦欲使本發明之epo受體促效劑鲁亦可各有位於原始蛋白端之一或兩者之胺基酸缺失，及/或於如上所示之式中具有由該等序列重排蛋白之新 N-及/或C-端之缺失。、过夕肽 (Η)中可產生新C-端及N-端之較佳斷裂點分為 23-24、24-25、25-26、33-34、34-35、35-36、36-37 、38·39、39_40 ' 4〇_41、64-65、65-66、66_67、67_68、68_69 、69-7〇、70-7卜 89-90、90务 91_92、92_93、93 94、μ % 、95-96、96_97、97_98、98_99、99_1〇〇、1〇〇 ι〇ι、ι〇ι ι〇2

O:\92\92747.DOC -40- 200413407 、102-103 、 103-104 、 104-105 、及105-106 。在上述多肽（II)中可產生新C-端及N-端之最佳斷裂點分另ll 為；64-65、65-66、92-93及 93-94 〇在上述多肽（III)中可產生新C-端及N-端之較佳斷裂點為 ;36-37、37-38、39-40、41-42、42-43、64-65、65-66、66-67 、86-87、87-88、88-89、89-90、90-91、91-92、92-93、93-94 、94-95、95-96、96-97、97-98、98-99、99-100、及 100-101。在上述多肽（III)中可產生新C-端及N-端之最佳斷裂點為 ;39-40、65-66、89-90、99_100及 100-101。在上述多肽（IV)中可產生新C-端及N-端之較佳斷裂點為 ;38-39、39-40、40-41、41-42、48-49、53-54、54-55、55-56 、56-57、5 7-58、58-59、59-60、60-61、61-62、62-63、64-65 、65_66 、 66-67 、 67-68 、 68-69 、 69-70 、 96-97 、 125-126 、126-127、127-128、128-129、129-130、130-131、131-132 、132-133、133-134、134_135、135-136、136-137、137-138 、138-139、139-140、140-141、及 141-142。在上述多肽（IV)中可產生新C-端及N-端之最佳斷裂點為 ’ 38-39、48_49、96-97、125-126、132-133及 141-142。在上述多肤（V)中可產生新C-端及N-端之較佳斷裂點為，28-29、29-30、3〇-31、31-32、32-33、33-34、34-35、35-36 ' 36-37、3 7-3 8、35-39、39-40、66-67、67-68、68-69、69 — 70 ' 70-71、84-85、85-86、86-87、87-88、88-89、89-90、90-91 、98_" ' 99-100、100-101、及 101-102。在上述多肤（V)中可產生新C-端及N-端之最佳斷裂點為

O:\92\92747.DOC 200413407 ;34-35 、 69-70及90-91° 在上述多肽（VI)中可產生新C-端及N-端之較佳斷裂點為 ;80-8 卜 81-82、82-83、83-84、84-8 5、85-86、86-87、108-109 、109-110、110-11卜 111-112、112-113、113-114、114-115 、115-116、116_117、117-118、118-119、119-120、120-121、 121-122、122-123、123-124、124-125、125-126、及 126-127。在上述多肽（VI)中可產生新c-端及N-端之最佳斷裂點為 ;81-82、108-109、115-116、119-120、122-123及 125-126。 · 本發明之多功能受體促效劑亦可以下式表示： (T1) a - ( L 1) b - X 1 - ( L ) c - X 2 - ( L 2) d - ( T 2) e 或 / X1-(L)c-X2-(L)-Y1.(L)c，y2 其中： X1係一肽，其含有相當於原始蛋白（其具有順序編號i至J 之胺基酸殘基’且其胺端位於殘基丨）之殘基n+丨至J之序列之胺基酸序列；鲁 L係選擇性之連接子； X2係一肽，其含有原始蛋白之殘基丨至n之胺基酸序列； Y1係一肽，其含有相當於原始蛋白（其具有順序編號丨至反之胺基酸殘基，且其胺端位於殘基1}之殘基n+isK之序列之胺基酸序列； Y2係-肽，其含有原始蛋白之殘基Un之胺基酸序列； L1及L2係選擇性之肽間隔臂； O:\92\92747.DOC -42- 200413407 η係介於1至J-1間之整數； b、c及d各獨立為0或1 ; a及e為0或1，惟a及e不可同時為0 ;及 T1及T2係蛋白質。本發明之多功能鑲嵌造血素受體促效劑可在該鑲嵌分子之各別蛋白組成份中含有胺基酸取代、缺失及/或插入。亦欲使本發明之多功能鑲嵌造血素受體促效劑亦可含有位於原始蛋白之N-及C-端之一或兩者之胺基酸缺失，及/或於如上所示之式中具有由該等序列重排蛋白之新N-及/或C-端之缺失。在本發明之具體實例中，連接N-端及C-及端之上式連接子（L)、（L1)或（L2)係一多肽，其選自：

Ser ;

Asn ;

Gly ;

Thr ；

GlySer ;

Ala Ala:

GlySerGly ;

GlyGlyGly ；

GlyAsnGly ;

GlyAlaGly ；

GlyThrGly ；

AlaSerAla ; O:\92\92747.DOC -43 - 200413407

AlaAlaAla ； 01乂0匕017361*序列編號1^0:778; 01}^}1><}13^仙7〇以01>^1'序列編號^〇:779;

GlyGlyClySerGlyGlyGlySerGlyGlyGlySer序列編號NO:780;

SerGlyGlySerGlyGlySer序列編號N〇:781;

GluPheGlyAsnMet 序列編號NO: 782 ; 01此1^01)^17八311]^1序列編號1^0:783;

01\^1^017〇17八811〇17〇17八811^^序列編號>^〇:784;

GlyGlySerAspMetAlaGly序列編號NO:785; 8€心1><}1>^811〇1;/序列編號1^0:786;

SerGlyGlyAsnGlySerGlyGlyAsnGlySerGlyGlyAsnGly 序列編號ΝΟ··788 ;

SerGlyGlySerGlySerGlyGlySerGly序列編號NO:789; 01><}1}<}1}^力1}<}17序列編號1^0:791;

61><}1><}1>^化13<}13<}坆序列編號1^0:792; 01}<}1><}1)^心1><}1><}1}^1<}1}<}17序列編號>^0:793; 61}<}1}<}1}^心1}<}1}<}1}^犯1}<}1}<}1)^沿1；7序列編號]^〇:794; 01}<}1}<}1}^犯1}^31}^1}^101}^1}<}1}^沿1}<}1}<}1}^序列編號]^0:795;

GlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGly 序列編號NO :796 ;

ProProProTrpSerProArgProLeuGlyAlaThrAlaProThrAlaGlyGlnProProLeu 序列編號N〇_. 797 ; 卩]：〇?1'〇?1'〇丁印86$]：〇八1^?]：〇1^11〇1}^\1&1111八1&?]：〇1111*序列編號;^〇:795;及 O:\92\92747.DOC -44- 200413407 序列編號NO:

ValGluThrValPheHisArgValSerGlnAspGM^ 799。此外，本發明係騎含有編碼該多功能鑲嵌造血素受触促效劑之料⑽狀重組表現載體、其_之微生物^ 現系統、以及製備該多功能鑲嵌造血素受體促效劑之方、去。…本發明亦係關於含有該多功能鑲嵌造血素受體促效劑之醫樂組合物及使用該多功能鑲嵌造血素受體促效劑之方法。、除本發明多功能鑲嵌造血素受體促效歸活體内之用途 (外可預見活fa外〈用途可包括在注入病患體内之前刺激骨髓及血細胞活化及生長之能力。另一所欲之用途係用以進行活體内或活體外之樹狀細胞製造。咸信融合蛋白之較低親和性係（至少部分）因為各別殘基在納入㈣分子中時無法達成其天然之構形，或因為融合蛋白各別殘基活性位點間之空間位阻。本發明克服此等限制，提供新穎之多功能鑲嵌造血素受體促效劑，其具有相當或大於該镶後分子各別組成份之結合親和力。【貫施方式】本發明涵括由共價連結之多肽形成之多功能鑲嵌造血素文體促效劑’其各可經由一不同及專一之細胞受體作用，以起始互補性〈生物活性。血細胞生成作用須要_複合系列 < 細胞反應’其中幹細胞持續產生各主要譜系之大量成熱細胞。目削至少已有2〇種已知具有血細胞增殖活性之調節劑。此等增殖調節劑中大部分皆僅可刺激一或他種類型之活體外集落形成’由各調節劑所刺激之集落形成之確切 O:\92\92747.DOC -45 - 200413407 模式I相當不同。以集落數目或，發膽之細胞之譜系及成熟模式來 =:即劑可刺激完全相同之集落形成模式。增殖反應; 於經簡化之活體外培養系統中輕 ^ 勿逛仃分析。可分辨屮二種相當不同之參數：集落大小之- 細胞譜系。共有二或多種因子可作用、人木洛數目〈改變及机、 J作用於祖細胞，謗發較大數目夂子代形成，因而增加集术口〈大小。共有二或多種因子可允許較大數目之祖細胞進行增殖，因僅可對—種因子反應《不同子集之祖細胞存在，或因部分之祖細胞須在可產生反應之前’先經二或多種因子刺激。使用二或多種因子活化細胞上之其他受體可能會因初始不同之信號途徑合併成為一種共同之終途徑到達細胞核而增帛t絲分裂之信號（Metcaif、Nature 339:27、1989)。其他機制則可解釋協同作用。舉例而言，如一種信號途徑係由另一種由第二因子造成之信號途徑之中間活化作用而限制，此即可能產生超加性之反應。在某些情形中，一種受體類型之活化可誘發其他受體之增強表現（Metcalf、B1〇〇d 82:3515_3523、1993)。' 相較於單一因子，二或多種因子可造成不同之細胞譜系模式。夕功此鑲肷造血素受體促效劑之使用可因其不可能為任何單一因子所產生之增殖反應而具有潛在之臨床優勢。造血及其他生長因子之受體可分類為兩不同族群之相關蛋白：（1)酪胺酸激酶受體，包括上皮生長因子M_csf (Sherr，Blood 75:1，1990)及 SCF (Yarden et al.，EMBO J. 6:3341，1987)之雙體；及（2)造血素受體，其不含酪胺酸激 O:\92\92747.DOC -46- 200413407 酶域，但於其胞外區域具有明顯之同源性（Bazan，PNAS USA 87:6934-6938，1990)。此一後述族群包括紅血球生成素（EP〇）（D’Anndrea et al.，Cell 57:277，1989)、GM_CSF (Gearing et al·，EMBO J. 8:3667，1989)、IL，3 (Kitamura et al·，Cell 66:1 165，1991) > G-CSF (Fukunaga et al.? J. Bio. Chem. 265:14008-15, 1990)、IL-4 (Harada et al·，PNAS USA 87:857，1990)、IL-5 (Takaki et al.，EMBO J. 9:4367, 1990) 、IL-6 (Yamasaki et al.? Science 241:825，1988)、IL-7 (Goodwin ete al.，Cell 60:941-51，1990)、LIF (Gearing et al·， EMBO J. 10:2839， 1991)及 IL_2 (Cosman et al·，

Mol-Immunol. 23:935-94,1986)。此一後述受體族群大部分係以異源二聚體之高親和性形式存在。在連結配位體後，專一性之α -鏈變成與至少一種其他之受體鏈（/3 -鏈、τ -鏈）相連。許多此等因子皆共享共同之受體次單元。GM-CSF 、IL-3 及 IL-5 之 α -鏈共享同一之 /3 -鏈（Kitamura et al·，Cell 66:1165，1991; Takaki et al·，EMBO J. 10:2833-8，1991) ，而IL-6、LIF及IL-11之受體複合物則共享一共同之/3 -鏈 (gpl30) (Taga et al·，Cell 58:573-81，1989; Gearing et al·， Science 255:1434-7, 1992)。IL-2、IL-4、IL-7、IL-9及IL-15 之受體複合物共享一共同之T -鏈（Kondo et al. Science 262:1 874，1993; Russell et al.5 Science 266:1042-1045, 1993; Nogichi et al.? Science 262:1877, 1993; Giri et al.， EMBO J· 13:2822-2830, 1994)。多作用性造血因子之使用亦可藉由降低對於因子生產細 O:\92\92747.DOC -47- ^υυ413407 胞及其誘發系統之需士、而不而具有潛在之優勢。如細胞生產因子之能力有限，那麼 1仏’猎由減低每一因子之所需濃度，並知其結合使用，即可古 J有效降低對於因子生產細胞之需求。多作用性造血因子夕你m ^ 丁 <使用可降低原本所須之因子量，可能亦減少可能之惡性副作用。本發明之新穎化合物係以選自下列之式表示：

Ri_LrR2、R2-LrRi 或 H 其中R!及R2分別如上所定義。 2車乂佳係為具有與I不同但互補之活性之集落刺激因補居丨生」思^曰可增強或改變對於另一細胞調節劑之反底、之活性。&多肽係直接或經由一連接子部分而與&多 t接直接」 4足義多功能鑲篏造血素受體促效劑，其中多肽係在無肽連接子之情形下連接。因此，L代表一化學鍵或多肽部分，其同時將心及心以符合框構之形式連接，最常見者，b係一線性肽，其以醯胺鍵連接&及&，將心4羧端與L!之胺端連接，並將^之羧端與心之胺端連接。「以符合框構之形式連接」意指在編碼&及&之dNA 閱碩框構之間並無轉譯終止或破壞之情形。其他生長因子，亦即，集落刺激因子（CSFs)之非獨占性表列為細胞因子、淋巴因子、間白素、造血生長因子，其可與（I)、（II)或（III)連結，包括GM_CSF、G-CSF、c-mpi配位體（亦稱為丁P0或MGDF)、M-CSF、紅血球生成素（EPO) 、IL-1、IL_4、IL-2、IL-3、IL-5、IL-6、IL-7、IL-8、IL-9 、IL-10、IL-11、IL-12、IL-13、IL-15、LIF、flt3/fh2配位 O:\92\92747.DOC -48- 200413407 體、人類生長激素、B細胞生長因子、B細胞分化因子、嗜伊紅性粒細胞分化因子及幹細胞因子（SCF)(亦稱為青灰因子或c-kit配位體）。此外，本發明涵括經修飾之1^或112分予，或經突變或經修飾之編碼此等&或R2分子之DNA序列之用途。本發明亦包括多功能鑲嵌造血素受體促效劑，其中 1^或尺2係hIL-3變體、c_mpl配位體變體、或G-CSF變體。「 hIL-3變體」係定義為一種hIL-3分子，其具有胺基酸取代及 /或部分之hIL-3經刪除，如揭示於WO 94/12638、 94/12639及WO 95/00646中者，以及其他技藝中已知之變體〇「c-mpl配位體變體」係定義為一種c-mpl配位體分子，其具有胺基酸取代及/或部分之c-mpl配位體經刪除，如揭示於美國專利申請案系列編號08/383,035中者，以及其他技藝中已知之變體。「G-CSF變體」係定義為一種G-CSF分子，其具有胺基酸取代及/或部分之G-CSF經刪除，如揭示於本文中者，以及其他技藝中已知之變體。除上所列者外，教示於WO 94/12639及WO 94/12638中之IL-3變體、揭示於WO 97/12977中之G-CSF受體促效劑、揭示於WO 97/12978中之 c-mpl受體促效劑、揭示於WO 97/12979中之IL-3受體促效劑亦可為本發明之I或。於此，「IL_3變體」係指教示於^¥0 94/1263 9及〜0 94/12638中之11^3變體。於此，「融合蛋白」係指教示於WO 95/21 197及WO 95/21254中之融合蛋白。於此，「G-CSF受體促效劑」係指揭示於WO 97/12978 中之G-CSF受體促效劑。於此，「c-mpl受體促效劑」係指揭示於WO 97/12978中之c_mpl受體促效劑。於此，「IL-3 O:\92\92747.DOC • 49- 200413407 受體促效劑」係指揭示於WO 97/12979中之IL-3受體促效劑。於此’ 「多功能受體促效劑」係指教示於W〇 97/12985 中之多功能受體促效劑。連接基團（L!)一般為長度介於1及500胺基酸之多肽。連接兩分子之連接子較佳係設計為（1)可允許該兩分子分別獨乂進行折疊及作用，（2)不具有發展可干擾該兩分子之功能域之有序二級結構之傾向，（3)具有最低之可與功能蛋白域作用之疏水特徵，及（4)可為心及心提供空間分離，因而使 R i及R2可同時與單一細胞上其對應之受體進行作用。柔性蛋白之典型表面胺基酸包括Gly、Asn及Ser。事實上，可期待含有Gly、Asn及Ser之胺基酸序列之任何變體皆可符合上逑連接子序列之範疇。其他中性胺基酸，諸如Thr或Aia，亦可用於連接子序列中。其他之胺基酸亦可因欲於連接子序列中添加獨特之限制位點，以協助多功能鑲嵌造血素受 m促效劑之建構，而被包括於連接子中。本發明之較佳Ll連接子係選自下式··（Gly3Ser)n (序列編號NO: 861)、（Gly4Ser)n (序列編號NO: 862)、（Gly5Ser)n ( 序列編號NO: 863)、（GlynSer)n (序列編號N0: 864)、或 (AlaGlySer)n (序列編號no: 865)。高度柔性連接子之實例之一為存在於絲狀噬菌體，如，噬菌體 M13 或 fd (Schaller et al·，PNAS USA 72:737-741 1975)4 pill蛋白中之富含甘胺酸及絲胺酸之間隔臂區域。此種區域在pill表面蛋白之兩間提供了長且柔性之間隔臂區域。该間隔臂區域係由下列之胺基酸序列構成：

O:\92\92747.DOC -50- 200413407

GlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGluGlyGlyGlySerGlu GlyGlyGlySerGluGlyGlyGlySerGluGlyGlyGlySerGlyGlyGlySer (序列編號NO.· 800) 本發明亦包括其中涵括内肽酶辨識序列之連接子。此種切割位點可具有相當高之價值，其可分離多功能鑲嵌造血素受體促效劑中之各別組成份，以測定其是否在活體外適當折疊並具有活性。各種不同内肽酶之實例包括，但不限於，纖溶酶、腸激酶、激肽釋放酶、尿激酶、組織纖溶酶原激活物、梭菌蛋白酶、凝乳酶、膠原酶、儒氏逢蛇毒蛋白酶（Russelrs viper venom protease)、後脯胺酸切割酶、 V8蛋白酶、凝血酶及因子Xa。取自重鏈免疫球蛋白IgG、IgA、IgM、IgD、或IgE之鉸鏈區之肽連接子部分在經連接多肽間提供了一種角度關係。特別有用處者係其中半胱胺酸為絲胺酸取代之鉸鏈區。本發明之較佳連接子包括衍生自鼠IgG加馬2b鉸鏈區之序列，其中半胱胺酸經取代為絲胺酸。此等連接子亦可包括内肽酶切割位點。此等連接子之實例包括下列序列： IleSerGluProSerGlyProIleSerThrlleAsnProSerProProSerLys GluSerHisLysSerPro (序列編號 NO: 801)及 IleGluGlyArglleSerGluProSerGlyProIleSerTHrlleAsnProSer ProProSerLysGluSerHisLysSerPro (序列編號 NO: 802)。然而，本發明並不為所用連接子序列之形式、大小或數目限制，且其對於連接子之唯一要求為其在功能上不會干擾多功能鑲嵌造血素受體促效劑中各別分子之折疊及功能。 O:\92\92747.DOC -51 - 200413407 連接子l2之決定序列長度可由經或使用兩種方法用於R!及/或&中之連接子k之胺基酸序驗選擇，或由結構資料之引導進行選擇之結合。可製備小系列之連接子進行試

當典法取得結構資料時，可

Hopp & Woods，Mol. Immunol. _______

，Karpins & Scchulz，Naturwissenschaften 72:212-213, 1985) 。假設平均轉譯為每殘基2·〇至3.8 A，4匕即表示試驗之長度係介於0至30殘基間，且以〇至15殘基為較佳範圍。此種經驗系列之實例可為使用盒序列（諸如，「⑴广⑴严⑴严“。 )重複η遍，其中、2、3或4，以建構連接子。熟習此項技術者可知’在首要考慮其不為過長或過短之情形下，許夕長度或組合不同之此等序列皆可作為連接子（參見，

Sandhu, Critical Reev. Biotech. 12:437-462，1992);如其過長’熵效應可能會使立體折疊變得不安定，且其亦可能使折疊成為動力學上不可實行之情形，且如其過短，其可能會因為扭轉或空間變形而使分子變得不安定。熟習蛋白質結構資料分析者可知，鏈末端間之距離（其以 ^阿法後原子間之距離定義）可用以定義所用序列之長度，

O:\92\92747.DOC -52- 或土 >可縮限必需使用連接子之經驗選擇進行試驗之可能 {生〇甘、__ /、I可知’有時多肽鏈末端之位置在衍生自X-射線繞、或核磁共振光譜數據之結構模型中定義不明，而當此情、 T ’此一情形則必需置入考慮，以適當估計所需連接子〈長度。從位置清楚定義之殘基中，選出兩位置於序 J中接近4連末端之殘基，並使用其c-阿法碳原子間之距離冲算其間連接子之概略長度。使用該計算長度作為引導，即選槎+ JL + # _ ^ /、有木—範圍殘基數目（使用每殘基2.0至3·8 Α計 #所侍者）足連接子。此等連接子可由原始序列構成，視需要、、、1§短或加長，且當加長時，可如上所述選擇柔性及親水、裏、外&基’或者該原始序列可選擇性經取代，以使用系列乏連接子，其實例之一為上述之「Gly-Gly-Gly-Ser 」基因盒法·’或者可選擇性使用具有適當總長度之原始序列及新序列之結合。

Ri及R2之胺及羧端之決定可折&至生物活性狀態之Ri及序列之製備可藉於原始多肽鏈中選擇適當之起點（胺端）及終點（羧端）位置，且使用如上所述之連接子序列k而進行。胺及羧端係使用下述之、’、岡領，由一共同之序列段（其稱為斷裂點區域）中選出。因此，藉著自同樣之斷裂點區域中選出胺及羧端，即產生新穎之胺基酸序列。在許多情形中，新穎終端之選擇係使該羧端足原始位置毗鄰於胺端之前。然而，熟習此項技術者可知，可在該區域中之任何位置選擇終端，且此等選擇可有效地對新序列之胺基或羧基部分造成缺失或加成。 O:\92\92747.DOC -53- 200413407 分子生物學之φ、、t、.、〜教義主張，蛋白質之一級胺基酸序列指揮其折疊成為矣％ &，為表現其生物功能所必需之立體結構。熟習此項技術者已知社夕、t 、、4夕万法，藉由單一蛋白結晶之X-射線繞射或虫白'合，夜 < 核磁共振光譜，取得並釋義立體結構資料。與*識斷裂點區域相關之結構資料之實例包括蛋白二級、、口構之ix置及類型（α及3_1()螺旋，平行及反平行6折疊，鍵回轉及轉角，以芬s · ^ » Kabsch & Sander, Biopolymers 22 7 2637’ 1983) ’胺基酸殘基之溶劑接觸程度，殘基間人互作用之私度及類型（Ch〇thia，Ann· Rev Bi〇chem· 53.53 7 572, 1984) ’以及沿多肽鏈之構形靜態及動力分布 ( & Mathews, Methods Ennzymoml. 1 54:51 1-533, 1987) 在木二h形中，亦知有關殘基之溶劑接觸之其他資料； s例為必走位於蛋白質表面之碳水化合物之後轉譯性連总位點。在未取得，或不可能取得實驗性之結構資料時，亦有許多方法可用以分析一級胺基酸序列，以預測蛋白貝之二級及二級結構、溶劑親近性、以及轉角及環之存在。當直接 < 結構方法不可能實行時，有時亦可使用生化方法，以進行外露表面之經驗性測定；舉例而言，可在限制性蛋白酶解後，使用鏈斷裂位點之辨識，以推論外露表面 (Gentile & Salvatore, Eur. J. Biochem. 218:603-621, 1993) 〇因此，不論使用由實驗衍生之結構資料或預測方法（如，

Srmvisan & Rose, Proteins: Struct., Funct. & Genetics, 22:81-99, 1995)，其皆檢視母胺基酸序列，以根據其是否為維繫二級及三級結構之要素而對區域進行分類。如在區域 O:\92\92747.DOC -54- 200413407 中發現已知涉及週期性二級結構（α及3-10螺旋，平行及反平订/3折疊）之序列存在，即應避開該等區域。同樣，經觀 ^、或預’則為具有低溶劑接觸程度之胺基酸序列區域即較可月匕為稱作蛋白質疏水核之一部分，且亦應避免用於選擇胺 k ^ 相對而吕’已知或經預測係位於表面轉角或環之區域’特別是已知不為生物活性所必須之區域，即為定位多肽鏈末端之較佳位點。根據上述標準而為較佳者之連續月文基酸序列段落即稱為斷裂點區域。亦可加入其他肽序列，以協助多功能鑲嵌造血素受體促效蛋白之純化或辨識（如，聚_His)。亦可加入可藉由專一性 <早株抗體進行快速分析，並協助多功能鑲嵌造血素受體促效蛋白純化之高度抗原性肽。「哭變胺基酸序列」、「突變蛋白」、「變體蛋白」、「突變體」、或「突變多肽」係指一多肽，其具有因胺基酉又缺失、取代、或兩者，而與天然序列不同之胺基酸序列，或係由一故意使其與天然序列不同之核苷酸序列所編碼者天然序列」係指一胺基酸或核苷酸序列，其與野生型或天然形式之基因或蛋白完全相同。迨血生長因子可以其刺激由人類造血組細胞所進行之集落形成作為特徵。該等經形成之集落包括血細胞、粒細2 、巨核細胞、粒細胞巨噬細胞'及其混合物。許多造血生長因子皆已在開始於靈長類動物，並繼續於人體進行之研九中，展現其使骨髓功能及外周血細胞族群恢復至醫療有证程度之能力。在造血生長因子之諸等生物活性中，許多 O:\92\92747.DOC -55- 200413407 或全邵皆涉及信號傳導及高親和多功能# $、止a _ 又肢連、、、口。本發明明之相較#_ π ，」了具有有用〈特性，諸如， “早-时，其具有類似或較高之活性 :經改良之半生期或較低之惡性副作用，或此等特性:結或無促效劑活性之多功能镶嵌造血素受體促效 Ο:可作為拮抗劑，作為抗原以製備抗體用於免疫學或有用之肌·3突變體。 M W料建構其他本發明多功能鑲嵌造血素受體促效蛋白之生物活性可藉依賴性細胞系中之DNA合成’或藉由活體外骨髓分析中集落形成單位之計數而進行測定。生相較於單-作用性之造血促效劑，本發明之多功能鑲嵌 :血素受體促效劑可具有改良之醫療特性。舉例而言，部分之本發明多功能鑲嵌造血素受體促效劑可具有相對於並他造血促效劑之相似或較強之生長因予活性，而不具有相似或相對之副作用增加情形。本發明亦包括編碼多功能鑲嵌造血素受體促效蛋白之 DNA序列，實質上相似且實質上表現相同功能之雇序列，以及僅因基因密碼之簡并性而與編碼本發明多功能镶丧造血素受體促效劑之DNA具有差異之DNA序列。本發明亦包括用於建構突變DNA之寡核苷酸中間體，以及由此等寡核苷酸編碼之多肽。目前技藝中之標準基因工程技術（美國專利4,935,233及 O:\92\92747.DOC -56- 200413407

Sambrook et al·，Molecular Cloning A Laboratory Manual，’’ Cold Spring Harbor Laboratory，1989)可用於建構本發明之 ΝΑ序列。此等方法之一為盒式诱變（以^從6 mutagenesis) (Wells et al·，Gene 3 4:3 15-323，1985)，其中將質體中之一部分編碼序列以合成之寡核苷酸取代，該寡核苷酸在介於兩限制位點間之一基因部分中，編碼有所欲之胺基酸取代。可製備編碼目標基因之互補性合成寡核苷酸對，並使其互相退火。經取代及/或由該序列刪除之胺基酸外，該寡核荅酸之DNA序列可編碼除目標基因之胺基酸序列。可以選擇之限制核酸内切酶處理質體DNA，然後使其與經退火 < 寡核苷酸稼接。可使用經稼接之混合物轉形感受態之JM101細胞，以使其對適當抗生素產生抗性。可挑取單一菌落，並以限制分析及/或DNA定序檢視質體〇1^八，以辨識具有目標基因之質體。新穎多功能鑲嵌造血素受體促效劑之DNA序列與其他集落刺激因子之DNA序列之選殖可使用中間載體達成。或者，可將基因直接選殖進入含有其他基因之載體中。可使用連接子及銜接子連接DNA序列，以及取代漏失之序列，其中，在目標區域内部原有-限制位點。因此，編碼多月太、肽連接子、以及其他多肽之基因物質（DNA)即被插入一適當 < 表現載體中，該載體即再用於轉形細菌、酵母菌、昆蟲細胞或哺乳動物細胞。以標準技術使經轉形之有機體= 行生長，並分離蛋白。因此，所得之產物即為一新穎蛋白，其具有以連接子區域與第二集落刺激因子連結之集落刺

O:\92\92747.DOC -57- 200413407 激因子。 j發明之l壽提供㈣表現料新穎多功能镶錢素文體促效劑之質體DNA載體。此等載體含有如上所述編:本發明新穎多肽之新穎舰序列。可轉形能夠表現多功犯叙嵌造血素受體促效劑之適當載體包括表現載體，其含有編碼該多功能鑲嵌造血素受體促效劑之料酸序列，孩序列與根據所用宿主細胞選擇之轉錄或轉譯調控序列連如上所述納入經修飾序列之載體涵括於本發明中，且可用於製備多功能鑲嵌造血素受體促效多肽。用於該方法中之載體亦含有經選擇之調控序列，其與本發明之dna編碼序列有操作性之相連關係、，且其可指導該序列在經選擇宿主細胞中之複製及表現。本發明之另一範疇提供製備新穎多功能鑲嵌造血素受體促效劑之方法。本發明之方法包括培養適當之細胞或細胞系，其已經含有編碼新穎多功能鑲嵌造血素受體促效劑表現之DNA序列之載體轉形。適當之細胞或細胞系可為細菌細胞。舉例而言，各種大腸桿菌之菌株皆為生物技術領域中所热知之宿主細胞。此等菌株之實例包括大腸桿菌菌株 JM101 (Yanish-Perron et al·，Gene 33:1〇3_119，1985)及 MON105 (Obukowicz et al.，Applied Environmental Microbiology 58:1 5 1 1-1523, 1992)。本發明亦包括根據噬菌體Mu ’使用大腸桿菌之染色體表現載體之多功能鑲嵌造血素受體促效蛋白之表現（Weinberg et al.，Gene 126:24_33, O:\92\92747.DOC -58- 200413407 1 993)。亦可於此方法中使用各種枯草芽胞桿菌之菌株。亦可取得諸多熟習此項技術者所知之酵母菌細胞菌株作為宿王細胞，以表現本發明之多肽。當於大腸桿菌之細胞質中進行表現時，編碼本發明多功能鑲嵌造血素受體促效劑之基因可亦建構為使其在基因密碼子之5 ’端進行加成，以於該蛋白又N-端編碼Met^Ala·1-或Met·1。於大腸桿菌之細胞，、中製備之蛋白之會為甲硫胺酸胺肤酶（Ben Bassat et al·’ J· Bac. 169:75 1-757，1987)，或可能為其他肽酶進行後

轉譯處理，以致於在進行表現時，甲硫胺酸會由卟端切除。本發明之多功能鑲嵌造血素受體促效劑可包括於端具有Met·1、Ala·1或Met·2-Ala·1之多功能鑲嵌造血素受體促效多肽。此等多功能鑲嵌造血素受體促效劑之突變體亦可藉著將一分泌信號肽融合至其斗端而於大腸桿菌中表現。此仏號肽會在分泌過程中由該多肽上切除。其他用於在大腸桿菌中達成基因高濃度表現之策略可見於Savvas，CM (Microbiological Reviews 60:5 12-538，1996)。哺乳動物細胞亦適用於本發明中，諸如中國倉鼠卵巢細胞（CHO)。在哺乳動物細胞中表現外來基因之一般性方法已審閱於 Kaufman，R.J., 〇987) “心

Principles and Methods，Vol. 9, L κ· Setl〇w，edit〇r，plenum

Press，New York*。其建構一表現載體，其中一可在哺乳動物細胞中作用之強啟動子驅動真核分泌信號肽編碼區域之轉錄，該區域在轉譯上與多功能鑲嵌造血素受體促效劑之編碼區域相連。舉例而言’可使用諸如pcDNA i/Ne〇、 O:\92\92747.DOC -59- 200413407 pRc/RS V 及 pRc/CMV (取自 Invitrogen Corp.，San Diego, California)之質體。該真核分泌信號肽可為取自該基因本身，或為取自其他分泌哺乳動物蛋白者（Bayne, M.L. ete al., Proc. Natl· Acad. Sci. USA 84:2638-2642, 1987)。在建構含有該基因之載體後，將載體DNA轉染進入哺乳動物細胞。此等細胞可為，舉例而言，COS7、HeLa、BHK、CHO、或小鼠L細胞系。此等細胞可於，舉例而言，DMEM培養基中 (JRH Scientific)進行培養。在轉染細胞之後，或在進行抗生素抗性篩選而建立安定細胞系後，再進行24-72小時之瞬時表現後，分泌進入培養基中之多肽可以標準生化方法回收。適當哺乳動物宿主細胞之選擇，以及轉形、培養、複製、篩選、以及產物製備及純化之方法係技藝中已知者。參見，如，Gething and Sambrook，Nature 293:620-625，1981 ，或者，Kaufman et al., Mol. Cell. Biol·，5(7):1750·1759， 1985，或 Howley et al·，美國專利 No. 4,419,446。另一適當之哺乳動物細胞系係猴COS-1細胞系。一類似可用之哺乳動 φ 物細胞系係CV-1細胞系。如有須要，可於本發明之方法中使用昆蟲細胞作為宿主細胞。參見，如，Miller et al·，Genetic Engineering，8:277-298 (Plenum Press 1986)及其中所引述之參考文獻。此外，使用桿狀病毒於昆蟲細胞中表現外來基因之一般性方法已述於 :Summer，M.D. and Smith，G.E. (1987)- A manual of methods for Baculovirus vectors and insect cell culture procedures, Texas Agricultural Experiment Station Bulletin O:\92\92747.DOC -60- 200413407

No. 1 555。其建構一含有桿狀病毒轉移載體之表現載體，其中，一種強桿狀病毒啟動子（諸如，多角體啟動子）驅動真核分泌信號肽編碼區域之轉錄，該區域在轉譯上與多功能鑲嵌造血素雙體促效劑之編碼區域相連。舉例而言，可使用貝月旦 pVL1392(取自 Invitr〇gen c〇rp·，San Dieg〇,

California)。在建構帶有編碼多功能鑲嵌造血素受體促效多肽< 載體後，其將2微克之此種DNA與1微克之桿狀病毒 DN山A共轉染進人昆蟲細⑩，細胞株㈣中。❹帶有多功能鑲嵌造血素受體促效劑之純重組桿狀病毒，於，舉例而言，ExCel 401無血清培養基中（JRH Biosciences，Lenexa Ka娜），感染經培養之細胞。分泌進入培養基中之多功能鑲後造血素受體促效劑可以標準生化方法回收1自表現多功能鑲嵌造血素受體促效蛋白之哺乳動物或昆蟲細胞之上清液可先使用任何市售之濃縮單元進行濃縮。本毛月之夕功此鑲嵌造血素受體促效劑可用於治療特徵

在於降低濃度之骨髓細胞、血細胞、(林巴細胞、或造血系巨;tet或其結合〈疾病。此外，其可用於活化成奴骨細胞及/或淋巴細胞。可以本發明多肽治療之疾病。括白血球減^症(leuc〇pen⑻’即外周血中之循環性白血球（白細胞）數目〈減少。白血球減少症可藉接觸某些病毒或接觸放射線而謗發。 ”吊為各料式〈癌症治療，如，接觸化療藥劑、放射線’以及感染或出血之副作用。以本發明之多功能镶嵌造血素受體促效劑所進行之白血球減少症之治療，可避免由

O:\92\92747.DOC -61 - 200413407 以目前可取得之藥物進行治療所造成之不欲副作用。本蠢明《多功能鑲嵌造血素受體促效劑可用於治療嗜中 m例而言，治療諸如成形不能性貝血、循環性嗜中性白血球減少症、自發性嗜中性白血球減少症、Chediak-Higashi症候群、全身性紅斑性狼療(sle) 白血病月姆毛同不良症候群、以及骨髓纖維變性之疾病。本發明《多功能鑲嵌造血素受體促效劑可用於治療或預防血小板減少症。目前’血小板減少症唯—之治療係血：板輸血，其極為昂貴’且帶有極大之感染（hiv、刪）及里源免疫之風險。多功能鑲嵌造血素受體促效劑可減輕或消除對於血小板輸血之需求。嚴重之血小板減少症可能係由基因缺陷造成’諸如’ F_ni氏貧血、Wis曝鳩咖、或May HeggUn症候群。後天之血小板減少症可能係由自體 -或異源-抗體造成，諸如’免疫血小板減少性紫斑症、全身性紅斑性狼瘡、溶血性貧血、或胎兒母體不相容性。此外，巨脾症、散布性血管内凝血症、血栓性血小板減少性紫斑症、感染、或人工心臟瓣膜亦可能造成血小板減少症。嚴重之血小板減少症亦可能由化療及/或放射治療或癌症產生。血小板減少症亦可能由癌瘤、;林巴瘤、白血病或纖維變性之骨髓侵襲而產生。

本發明之多功能镶喪造血素受體促效劑可用於在外周血中移動造血組細胞及幹細胞。衍生自外周血之組細胞已經證實可在自體骨髓移植之復原過程中有效重建病患。造I O:\92\92747.DOC -62- 200413407 生長因子’包括G-CSF及M-CS CSF，已經證實可增加外周血中

hIL-3，已被單獨投藥，與其他CSFs共投藥，或與骨髓移植物結合’再續以高劑量之化療，以治療嗜中性白血球減少症及血小板減少症，其通常為此種治療之結果。然而，嚴重嗜中性白血球減少症及血小板減少症之週期可能無法完全消除。骨髓瑨系（其包含單核細胞（巨噬細胞）、粒細胞（包括嗜中性白細胞）、及巨核細胞）對於預防可能危及生命之感染及出血而言相當重要。嗜中性白血球減少症及血小板減少症亦可能為疾病、基因缺陷、藥物、毒素、放射線、及許多醫療性治療（諸如習用之癌症治療）之結果。骨髓移植已被用於治療此一病患群。然而，與使用骨髓以重建折衷之造血系統相關之多種問題包括·· 1}骨髓、胰臟或外周血中之幹細胞數目有限，2)移植物抗宿主疾病， 3)移植物排斥，及4)可能之腫瘤細胞污染。幹細胞僅占骨髓、胰臟及外周血中有核細胞之極小百分比。其清楚存在一種劑量反應，數目越多之幹細胞即可增進造血之復原。因此，幹細胞之活體外擴展應可增進造血之復原及病患之存活率。取自異源提供者之骨髓已被用於提供移植所需之骨 O:\92\92747.DOC -63- 200413407 然而’移植物抗宿主疾病以及移植物排斥限制了骨髓 :植’甚至是在HLA_相符之同胞接受者體内。異源骨髓移植《另-選擇即為自體骨髓移植。在自體骨髓移植中，立在骨髓切除治療前（例如，高劑量之化療），先收集部分病輿、自身之骨髓，並於之後將其移植回到病患體内。自體骨髓移植消除了移植物抗宿主疾病以及移植物排斥的風險。然而，自體骨髓移植仍因骨髓中有限數目之幹細胞及可此之腫瘤細胞污染而有其問題。幹細胞數目有限之問題可=由幹細胞之活體外擴展而克服。此外，可根據專—性之表面抗原（諸如，⑶34+)而專一性分離幹細胞，以減少骨髓移植物中之腫瘤細胞感染。下列 < 專利包含有關幹細胞分離、CD34+細胞、以造血因子培養細胞、該等細胞用於治療患有造血疾病之病患之用途、以及造血因予用於細胞擴展及基因治療之用途之進一步詳述。 5,061，62G係'關於含有人類造血幹細胞之組合物，該等細胞係藉自奉獻細胞分離幹細胞而提供。 5，199,942描述一種自體造血細胞移植之方法，其包含： (1)自病病患體内取得造血組細胞；（2)以生長因子進行活體外細胞擴展，該因子係選自化_3、fh3配位體、c-kh配位2 、GM-CSF、IL-1、GM_CSF/IL_3融合蛋白、及其組合；⑺ 將細胞製備物投予病患。 5,240,856係關於一種細胞分離儀，其包括一種自動控制細胞分離過程之裝置。 O:\92\92747.DOC -64- 200413407 WO 91/161 16描述自細胞混合物中選擇性分離及區隔目標細胞之裝置及方法。 WO 9 1/1 8972描述於活體外培養骨髓之方法，其係使用空心之纖維生物反應器培養骨髓細胞懸浮液而進行。 WO 92/18615係關於在含有細胞因子特定混合物之培養基中維持及擴展骨髓細胞以用於移植物中之方法。 WO 93/08268描述選擇性擴展幹細胞之方法，其包含下列步騾：（a)將CD34 +幹細胞與其他細胞分離，及（b)於選擇性培養基中培養該經分離之細胞，以使幹細胞選擇性擴展。 WO 93/1 8 136描述於活體外支持衍生自外周血之哺乳動物細胞之方法。 WO 93/1 8648係關於一種用於治療遺傳性或後天性嗜中性白血球減少症之組合物，其含有人類嗜中性白細胞前體細胞，並有高含量之成髓細胞及前髓細胞。 WO 94/08039描述藉由選擇表現c-kit蛋白之細胞以富集人類造血幹細胞之方法。 WO 94/1 1493描述一種幹細胞族群，其為CD34 +且小之細胞，其係使用對流淘析法分離。 WO 94/27698係關於一種結合免疫親和分離法及連續流動離心分離法，以自非均相細胞混合物中選擇性分離有核非均相細胞族群之方法。 WO 94/25848描述一種用於收集及操縱目標細胞之細胞分離裝置。於含有IL-la、IL-3、IL-6或GM-CSF之培養物中，對取自 O:\92\92747.DOC -65 - 200413407 人類骨髓之南度富集性造血組細胞CD34 +前體細胞進行長期培養之方法則述於Brandt et al.，J. Clin. Invest. 86:932-941， 1990 〇本發明之一範疇提供選擇性於活體擴展外幹細胞之方法。「幹細胞」一詞係指可由骨髓、胰臟或外周血中分離之全旎造血幹細胞，以及早期前體細胞及組細胞。「擴展」一詞係指細胞之分化及增殖。本發明提供一種選擇性於活體擴展外幹細胞之方法，其包含下列步驟：（a)將幹細胞與其他細胞分離，（b)以含有多功能鑲嵌造血素受體促效蛋白之選擇性培養基培養該等經分離之幹細胞，及（c)收集該等幹細胞。幹細胞以及將成為嗜中性白細胞、紅血球、血小板等之定型組細胞，可以根據是否具有存在於此等細胞表面之特定組細胞標記，諸如CD34，及/或根據形態特徵，而與大部分之其他細胞區分。高度富集性之人類幹細胞部分之基因型已被報告為CD34+、Thy-1+、及lin_，但可明瞭本發明並不限於此種幹細胞族群之擴展。CD34+富集性之人類幹細胞部分可以許多已經報告之方法分離，包括親和管柱或珠、、磁性珠或流式細胞計量，使用對抗表面抗原（諸如 CD34 + )之抗體。同時，可使用物理分離方法，諸如，對流淘析法’以富集造血組細胞。CD34+組細胞係非均相者，U 且可被區分為數種次族群，此等次族群之特徵為有或無不同之^晋系相關性細胞表面連結分子之共表現情形。最不成热知組細胞並不表現任何已知之譜系相關性標記，諸如， HLA-DR 或 CD38，然其可表現 CD9〇 (th : ^ ；其他表面抗原

O:\92\92747.DOC -66- 200413407 ,；"^CD33'CD38'---D71.HLA-DR.4c.kit 用於進料結細胞之選擇性转。可在培養瓶、無囷&或κ纖維内’於經選擇之培養基中培養經分離之、田也可使用各種集落刺激因子，以選擇性擴展細胞。已被用於骨髓之活體外擴展之代表性因予包括，㈣配位體 ^小⑽卜⑽携七卜^化七㈤配位體、或其組合。幹細胞之增殖可以標準技術（例如，血細胞計數、CFU、LTCIC)藉由計算幹細胞及其他細胞之數目，或在培養前後藉由流式細胞計量而予以監控。各種活體外之幹細胞擴展方法皆已經報告，其使用多種篩選方法，並使用各種集落刺激因子進行擴展，包括c_kit 配位體（Brandt et al·，Blood 83:1507-1514 [1994]，McKenna et al·，Blood 86:3413-3420 [1995])、IL-3 (Brandt et al·，

Blood 83:1507-1514 [1994], Sato et al.5 Blood 82:3600-3609 [1993])、G-CSF (Sato et al·，Blood 82:3600-3609 [1993])、 GM-CSF (Sato et al.，Blood 82:3600-3609 [1993])、IL-1 (Muench et al·，Blood 81:3463-3473 [1993])、IL-6 (Sato et al·，Blood 82:3600-3609 [1993])、IL-11 (Lemoli et al·，Exp.

Hem. 21:1668-1672 [1993]，Sato et al·，Blood 82:3600-3609 [1993])、flt-3 配位體（McKenna et al·，Blood 86:3413-3420 [1995])、及/或其組合（Brandt et al·，Blood 83:1507-15 14 [1994]，Haylock et al·，Blood 80:1405-1412 [1992]，Koller et al.，Biotechnology 1 1:358-363 [1993]，Lemoli et al·，Exp. Hem. 21:1668-1672 [1993]， McKenna et al·， Blood

O:\92\92747.DOC -67- 200413407 86:3413-3420 [1995], Muench et al.? Blood 81:3463-3473 [1993] ，Patch et al·，Biotechnology 7:13-26 [1994]，Sato et al.? Blood 82:3600-3609 [1993], Smith et al.5 Exp. Hem. 21:870-877 [1993], Steen et al.? Stem Cells 12:214-224 [1994] ，Tsuujino et al·，Exp· Hem· 21:1379-1386 [1993])。在各別之集落刺激因子中，hIL-3已經證實為在擴展外周血 CD34+細胞方面最強效之因子之一（Sat〇 et a]l.，BlQQd 82:3600-3609 [1993]，Kobayashi et al·，Blood 73:1836-1841 [1 989])。然而，並未有任何單一因子已被證實可與多種因子之組合同樣有效。本發明提供活體外擴展之方法，其使用較單一因子更為有效之多功能鑲嵌造血素受體促效劑。本發明之另一範疇提供維持及/或擴展造血前體細胞之方法，其包括將細胞接種進入培養容器中，該容器含有已藉接觸基質細胞系（諸如，HS-5)予以調節（w〇 96/〇2662,

Roecklein and Torok-Strob，Blood 85:997-1 105, 1995)，且已添加本發明之多功能鑲嵌造血素受體促效劑之培養基。可預見本發明多功能鑲嵌造血素受體促效劑之用途可包括血液積存應用’其中在某些醫療流程之前，對病患施予 EPO受體促效劑’以增加血細胞數目，並將血液產品由病患體内取出。貯存該等血液產品，並於該醫療流程之後，再將其輸血回㈣病患㈣。料，可預見多功能鑲嵌造血素受體促效劑之用4 士 J t 了包括在扣血之前，對血液提供者施予多功能鑲歲造血素受體促效劑，以增加血細胞數目，因而使該提供者可安全地提供較多之血液。

O:\92\92747.DOC -68- 200413407 生長因子之另一具體臨床用途係在於對造血組細胞及幹細胞進行活體外活化以用於基因治療。由於造血組細胞之長生命期以及其子代細胞遍佈全身之分布，造血組細胞係進行活體外基因轉染之極佳候選者。為將目標細胞納入造血組細胞或幹細胞之基因組中，必需刺激細胞分裂及DnA 複製。造血幹細胞係以低頻率循環，換言之，生長因子對於增進基因轉導，並因此改良其基因治療之臨床範疇而言非常有用。可能之基因治療應用（參閱Crystal，Science 270:404-410 [1995])包括；1)諸多先天性代謝疾病及免疫缺陷之治療（Kay and Woo，Trends Genet· 10:253-257 [1994]) ’ 2)神經疾病（Friedmann，Trends Genet· 10:210-214 [1994]) ，3)癌症（Culver and Blaese，Trends Genet. 10:174-178 [1994]) ’ 及 4)感染性疾病（Gilboa and Smith，Trends Genet. 10:139-144 [1994])。熟習此項技術者已知各種將遺傳物質引入宿主細胞之方法。多種載體（包括病毒性及非病毒性載體）亦已經發展，以用於將醫療性基因轉移進入原代細胞。基於病毒之載體包括’ 1)複製缺失性重組逆轉錄病毒（Boris-Lawrie and Temin， Curr. Opin. Genet. Dev. 3:102-109 [1993], Boris-Lawrie and Temin，Annal. New York Acad. Sci· 716:59-71 [1994]，

Miller, Current Top. Microbiol. Immunol. 158:1-24 [1992]) 及衩製缺失性重組腺病毒（Berkner，BioTechniques 6:616-629 [1988]，Berkner，Current Top. Microbiol.

Immunol. 158:39-66 [1992]，Brody and Crystal，Annal· New O:\92\92747.DOC -69- 200413407

York Acad· Sci. 716:90-103 [1994])。非基於病毒之載體包括蛋白質 /DNA 複合物（Cristiano et al·，PNAS USA 90:2122-2126 [1993], Curiel et al.? PNAS USA 88:8850-8854 [1991]，Curiel，Annal· New York Acad. Sci· 716:36.58 [1994])、電穿孔法及脂質體中介性傳遞，諸如陽離子脂質體（Farhood et al.，Annal. New York Acad· Sci. 716··23_35 [1994])。本發明為擴展造血細胞（其中已引入新基存方法提供改良，其中，其提供使用多功能㈣造者血體促效蛋白之方法，該等多功能鑲嵌造血素受體促效蛋白具有較佳《生物活性，包括未曾見於任何單一集落刺激因子之活性。此寺樂物之許多藥物皆可造成骨髓抑制或造血缺陷，一… 例諸如ΑΖΤ、DDI、认外由山、、用於化燎中《烷化劑及抗-代謝物生素（諸如，氯黴夸、主激r主 ^ * ㈢攻素、9_(1，3-二巍-2-丙氧甲基）口示吟、道i石撤素及爲胺藥％ . 、

，、妝条物）、酚噻嗪酮、安神劑（諸如，甲基-2-丙基-13 -丙-gt …甘 ^ 一％ —(胺基甲酸酯））、止痛劑（諸如，基比林及二P比喃_ )、抗痙攣劑（諸如，Phenytoin 、mazepme)、抗甲狀腺劑（諸如，丙硫尿料及美賽。、以及利尿劑。本於一、 & <夕功能鑲嵌造血素受體促效劑用於預防或治療常ψ _ ’、見万；给此等藥物治療之病患體内之骨达抑制或造血缺陷。造血缺陷亦可因五局届母、微生物或寄生蟲感染、發燒以及因為腎臟疾病戈乂同裳竭心治療（如，透析）而產生。本

O:\92\92747.DOC -70- 200413407 明之多功能鑲嵌造血素受體促效劑可用於治療此等造血缺陷。造血缺陷之治療可包括將含有多功能鑲嵌造血素受體促效劑之醫藥組合物施予病患。藉由在將細胞注射進入病患體内之前，先於活體外，以本發明之多功能鑲嵌造血素受體促效劑處理細胞，本發明之多功能鑲嵌造血素受體促效劑可用於活化及複製造血組細胞。各種免疫缺陷（例如，τ 及/或B細胞之免疫缺陷）或免疫疾病（例如，類風濕性關節炎 )亦可為本發明多功能鑲嵌造血素受體促效劑之治療而受到有益之影響。免疫缺陷可能為病毒感染（例如，HTLVI、 HTLVII、HTLVIII)、嚴重接觸輻射、癌症治療、或其他醫療性治療之結果。本發明之多功能鑲嵌造血素受體促效劑亦可用於（單獨使用或結合其他集落刺激因子）其他血細胞缺陷之治療，包括血小板減少症（血小板缺失）、或貧血。此等新穎多肽之其他用途包括於活體内或活體外治療自骨髓移植復原之病患，以及發展以標準方法產生之單株及多株抗體以用於診斷或治療。本發明之其他範w壽為治療上述疾病之方法及醫藥組合物。此等組合物含有醫療有效量之一或多種本發明多功能鑲嵌造血素受體促效劑與醫藥上可接受載體之混合物。此種組合物可由腸外、靜脈内或皮下投藥。當進行投藥時，用於本發明之醫藥組合物較佳係以不含致熱原，腸外可接受之水溶液形式存在。此種腸外可接受性蛋白溶液之製備（有關其pH、等張性、安定性等）係在此技藝之技術範圍妹内。 O:\92\92747.DOC -71 - 200413407 本發明多功能鑲嵌造血素受體促效劑之另一目標用途係用於自前體細胞產生較多數目之樹狀細胞，而以其作為免疫之佐劑。樹狀細胞在免疫系統中扮演著極重要的角色。其為可最有效活化靜息τ細胞之專業抗原呈遞細胞，且其為於活體内活化原初T細胞，並因此起始初次免疫反應之主要抗原呈遞細胞。其可有效内化、處理及呈遞可溶性腫瘤專一性抗原（Ag)。樹狀細胞具有獨特之能力，可聚集原初丁細胞，並藉由主要組織相容性複合體（MHC)&共刺激性分子表現之快速加級調控、細胞因子之生產、以及朝向淋巴器官之移動，而對Ag遭遇產生反應。由於樹狀細胞在敏化宿主對抗新抗原以進行CD4依賴性免疫反應之方面具有中心重要性，其亦可在腫瘤免疫力之產生及調控方面扮演重要之角色。树狀細胞係源自與粒細胞及巨嗟細胞相同之骨髓C d 3 4 + 前體細胞，且一可提供純樹狀細胞集落之分離樹狀細胞集落形成單元（CFU-DC)亦已於人體内建立。此外，亦已知一種後_CFU CD14+中間體，其在不同之細胞因子條件下，具有沿樹狀細胞或巨噬細胞途徑分化之潛力。此種雙潛力性之前體細胞存在於骨髓、臍帶血及外周血中。可根據專一性之細胞表面標記（諸如，CDla+、CD3-、CD4-、CD20-、 CD40+、CD80 +及CD83 + )分離樹狀細胞，以描繪經培養樹狀細胞之成熟過程。基於樹狀細胞之策略可提供增強對抗腫瘤及感染原之免疫反應之方法。AIDS係另一種可使用基於樹狀細胞之治療 O:\92\92747.DOC -72- 200413407 的疾病，因樹狀細胞可在啟動扭乂“複製之方面扮演重要角色。免疫治療包括由癌症病患體内產生樹狀細胞，使該等細胞於活體外接觸腫瘤Ag (其係衍生自以手術移除之腫瘤塊），再將此等細胞重新注射至該腫瘤病患體内。腫瘤細胞之相對粗製膜製備物可作為腫瘤抗原之來源，因而除去對腫瘤抗原進行分子辨識之必要性。腫瘤抗原亦可為合成肽、碳水化合物或核酸序列。此外，細胞因子（諸如，本發明之多功能鑲嵌造血素受體促效劑）之附隨投藥可進一步協助诱發腫瘤免疫力。咸可預見，免疫治療可在活體内環境中進仃’纟中係對一具有腫瘤之病患投予本發明之多功能鑲嵌造血素受體促效劑（單獨投藥或結合其他造血生長因子），以增加樹狀細胞之數目，而内源性腫瘤抗原係呈遞於該等樹狀細胞上。亦可預見，可使用外源性抗原進行活體 :之免疫治療。亦可預見’免疫治療可包括藉由對病患：二本發明之多功能鑲嵌造血素受體促效劑（單獨投藥或結口其他造血生長因子）以使樹狀細胞前體或成熟樹狀細胞移動’將樹狀細胞前體或成熟樹狀細胞由病患體内移除， :該等樹狀細胞與抗原接觸’再將該等樹狀細胞送回病患把内。同日寺，經移除之樹狀細胞可於活體外以本發明之夕功能鑲嵌造血素受體促效劑（單獨或結合其他造血生長= 子）進行培養’以在接觸抗原之前增加樹狀細胞之數目於樹狀細胞之策略亦可提供減低自體免疫 ^ 應之方法。 m 有關樹狀細胞之研究已因無法以足夠之數目及合理之純

O:\92\92747.DOC -73 - 200413407 化形式製備細胞之問題而受到嚴重阻礙。在活體外之細胞擴展環境中’粒細胞-巨嗟細胞集落刺激因子（GM-CSF)及腫瘤壞死因子-a (TNF- α )可在由取自骨髓、臍帶血或外周血之造血組細胞（CD34+細胞）產生樹狀細胞之活體外生成反應中共同作用’且flt-2/flt-3配位體及c_kit配位體（幹細胞因子[SCF])可產生協同作用而增強由gm-CSF及TNF- α謗發之樹狀細胞生成（Siena，S. et al.，Expedmental Hematology 23:1463_1471，1995)。本發明亦提供一種使用本發明之多功能鑲嵌造血素受體促效劑，於活體外擴展樹狀細胞前體或成熟樹狀細胞，以提供足量樹狀細胞進行免疫治療之方法。用於治療上述病況之方法中之藥劑攝取量可由主治醫生考慮各種可修飾藥物作用之因子而定，如，病況、體重、病患之性別及飲食習慣、任何感染之嚴重性、投藥時間及其他臨床因子。—般而言，4日攝取量可介於每公斤體重〇.2-15〇微克/公斤之多功能鑲嵌造血素受體促效蛋白之範圍。劑量可相對於特定多功能鑲嵌造血素受體促效蛋白之活性調整’且應可合理註記該等藥劑攝取量可包括每公斤體重低至〇. 1微克及高至丨毫克、毛克者。此外，亦可存在特殊之情況，料中，多功能鑲嵌造血素受體促效劑之劑量可調整為高於或低㈣公斤體動.2_15{)微克/公斤之範圍。此等情況包括與其他集落生長因子姐_3變體或生長因子之共投藥；與化療藥物及/或放射治療之共投藥；择基化多功能鑲嵌造血素受體促效蛋白之使用；以及如本段前文

O:\92\92747.DOC -74- 200413407 所述之各種與病患相關之問題。如上所言，本發明之醫療万法及組合物亦可包括與其他人類因子之共投藥。其他可與本發明多肽同時或序列共投藥之適當集落刺激因子 (CSFs)、細胞因子、淋巴因子、造血生長因子、及間白素之非獨占性表列包括GM-CSF、G_CSF、c_mpl配位體（亦稱為TPO或MGDF)、M-CSF、紅血球生成素（EP〇）、IL-丨、IL-4 IL 2 IL-3、IL-5、IL-6、IL-7、IL-8、IL-9、IL-10、IL-1 1 、IL-12、IL_13、IL_15、LIF、flt3/flt2配位體、b細胞生長因子、B細胞分化因子、嗜伊紅性粒細胞分化因子、幹細胞因子（SCF)(亦稱為青灰因子或c-kit配位體）、或其組合。可對上述之劑量進行調整，以補整本發明醫療組合物中之此等額外組成份。經治療病患之發展可由週期性之血液特性評估進行監測，如，分化細胞計數等。材料及方法除非另外指明，所有之特性化學品皆取自Sigma，Co. (St. Louis，MO)。限制核酸内切酶及T4 DNA稼接酶係取自New

England Biolabs (Beverly，ΜΑ)或 Boehringer Mannheim (Indianapolis，IN)。大腸桿菌菌株之轉形大腸桿菌菌株，諸如，DH5a™ (Life Technologies， Gaithersburg, MD)及 TGI (Amersham Corp.，Arlington Heights，IL)，係用於進行稼接反應之轉形，且為用於轉染哺乳動物細胞之質體DNA之來源。大腸桿菌菌株，諸如， JM101 (Yanisch-Perron，et al·，Gene，33:103-1 19，1985)及 O:\92\92747.DOC -75 - 200413407 MON105 (Obukowicz，et al·，Appl. and Envir. Micr.， 58:1 5 1 1-1523，1992)可用於在細胞質或外周質間隙中表現本發明之多功能鑲彼造血素受體促效劑。 MON105 ATCC#55204: F-? lambda-, IN (rrnD, rrE) 15 rpoD + ? rpoH358 DH5aTM； F-5 phi80dlacZdeltaMl 5? delta (lacZYA-argF) U169， deoR， recAI， endAI， hsdR17(rk-， mk+)，phoA， supE441amda-，thi-1，gyrA96，relAl TGI: delta (lac-pro)，supE，thi-1，hsdD5/F’ （traD36, proA+B + ? laclq, lacZdeltaMl 5) JM101 ATCC#33876: delta (pro lac)，supE，thi. F’（traD36, proA+B + 5 laclq, lacZdeltaMl 5) DH5a™次選殖效率細胞係以感受態細胞之形式購得，且

其可輕易使用製造商之流程進行轉形，而大腸桿菌菌株 TG1及MON105係使用CaCl2法使其成為感受態以攝取DNA 。一般而言，其係使20至50毫升之細胞，於LB培養基中（1% Bacto-胰化蛋白腺，0.5% Bacto-酵母萃取物，150 mM NaCl) ，生長至以 Baush & Lomb Spectronic分光光度計（Rochester， NY)於600 nm下測定為約1.0光學密度之密度（OD600)。以離心搜集細胞，將其重新懸浮於五分之一培養物體積之CaCl2 溶液中（50mMCaCl2，10 mM Tris-Cl，pH 7.4)，並將其置於 4°C下30分鐘。再次以離心搜集細胞，並重新懸浮於十分之一培養物體積之CaCl2溶液中。將經稼接之DNA加入0.毫升之此等細胞中，並將樣本置於4°C下3 0-60分鐘。將樣本轉 O:\92\92747.DOC -76- 200413407 移至42 C放置2分鐘，並在將樣本於37。€下震盪丨小時前，加入1.0毫升之LB。將取自此等樣本中之細胞塗抹於含有胺卞青黴素（100微克/毫升，mg/mL)(於選擇胺苄青黴素抗性轉形株時），或壯觀黴素（75微克/毫升）（於選擇壯觀黴素抗性轉形株時）之培養板上。將此等培養板置於37〇c下隔夜。挑取菌落，接種進入添加適當抗生素（100微克/毫升胺芊青 Μ素或75微克/¾升壯觀黴素）之lb中，並於37°C下震盪培養。創造具有新N_端/C_端之基因之方法方法I ··創造含有連接子區域（L2)且具有新N_端/(:_端之基因含有連接子區域（D分離原始C-端及N-端，且具有新端/C-端之基因可實質上根據述於L· s· MuUins，et al· (J·

Am· Chem· Soc· 1 16, 5529-5533, 1994)之方法而製備。其使用多步騾之聚合酶連鎖反應（PCR)擴增編碼蛋白質一級胺基酸序列之重排DNA序列。此等步驟如圖2所示。在第一步騾中，其使用第一引子組（「新起點」及「連接子起點」），由原始基因序列創造並擴增DNA片段（「片段起點」）’該片段含有編碼新蛋白N -端部分，並接續連接原始蛋白之C-知及之連接子（L2)之序列。在第二步.1〒中，其使用第二引子組（「新終點」及「連接子終點」），由原始基因序列創造並擴增DNA片段（「片段終點」），該片段編碼如上所用之相同連接子，並接續新蛋白端部分。「新起點」及「新終點」引子之設計使其包括可將新基因選殖進入表現質體之適當限制位點。典型之PCR條件係丨循環 O:\92\92747.DOC -77- 200413407 之95°C溶解2分鐘；25循環之94°C變性1分鐘，50°C黏連1分鐘，及72°C延伸1分鐘；再加上1循環之72°C延伸7分鐘。使用 Perkin Elmer Gene Amp PCR Core Reagents 套組。1 00微升之反應物含有各100皮莫耳（pmol)之引子及1微克之樣板 DNA ;以及 lx PCR緩衝溶液，200 // M dGTP，200 // Μ dATP，200 β M dTTP ^ 200 // Μ dCTP，2.5 單位 AmpliTaq DNA聚合酶及2 mM MgCl2。PCR反應係於Model 480 DNA 熱循環儀（Perkin Elmer Corporation，Norwalk，CT)中進行。 | 「片段起點」及「片段終點」（其具有連接子區域之互補序列及連接子兩側兩胺基酸之編碼序列）係於第三PCR步騾中連接，以製備編碼新蛋白之全長基因。DNA片段「片段起點」及「片段終點」係於1 °/。之TAE凝膠上離析，經溴化乙錠染色，並使用Qiaex Gel Extraction套組（Qiagen)分離。

將此等片段以等莫耳之量結合，於70°C下加熱10分鐘，並緩慢冷卻，以允許其經由「片段起點」及「片段終點」中之共有序列黏連。在第三PCR步騾中，其將引子「新起點 _ 」及「新終點」加入黏連片段中，以創造並擴增全長之新 N-端/C-端基因。典型之PCR條件係1循環之95°C溶解2分鐘 ;25循環之94°C變性1分鐘，60°C黏連1分鐘，及72°C延伸1 分鐘；再加上1循環之72 °C延伸7分鐘。使用Perkin Elmer GeneAmp PCR Core Reagents套組。100微升之反應物含有各100皮莫耳（pmol)之引子及約0.5微克之DNA;以及lx PCR 緩衝溶液，200 β M dGTP ^ 200 // M dATP，200 β M dTTP ，200 // Μ dCTP，2·5 單位 AmpliTaq DNA 聚合酶及 2 mM O:\92\92747.DOC -78- 200413407

MgCl2。PCR反應物以pCR ρΓ^套組听麵啡）純化。万法II ··創造不含連接子區域且具有新^端/c —端之基因不含連接原始C-端及N-端之連接子區域仏」，且具有新 N-端/C-端之基因可使用兩步騾之pCR擴增及一鈍端稼接製備此等步驟如圖3所示。在第一步驟中，其使用引子組（「新起點」及「P-bl起點」），由原始基因序列創造並擴增 DNA片& (片段起點」），該片段含有編碼新蛋白端部分之序列。在第二步驟中，其使用引子組（「新終點」及厂 p-bi終點」），由原始基因序列創造並擴增dna片段（「片段終點」），該片段含有編碼新蛋白^端部分之序列。「新起點」及「新終點」引子之設計使其包括可將新基因選殖進入表現質體之適當限制位點。典型之PCR條件係丨循環之95 C A解2分鐘，25循環之94 °C變性1分鐘，5 0°C黏連45秒，及 72 C L 伸 45 秒。使用 Deep Vent 聚合酶（New England

Biolabs)以減低在製造商所推薦條件下突出端發生之情形。「P-bl起點」及「p_bl終點」引子於5,端經磷酸化，以協助接續之「片段起點」及「片段終點」之鈍端稼接反應。 100微升之反應物含有各150皮莫耳（pmol)i引子及1微克之樣板 DNA ;以及 ΐχ Vent 緩衝溶液（New England Biolabs) ’ 300 // M dGTP，300 // M dATP，300 // M dTTP，300 // Μ dCTP及1單位Deep Vent聚合酶。PCR反應係於ModeM80 DNA熱循環儀（Perkin Elmer Corporation，Norwalk，CT)中進行。PCR反應物以 Wizard PCR Preps套組（Promega)純化。引子之設計使其包括可將新基因選殖進入表現質體之適 O:\92\92747.DOC -79- 200413407 當限制位點。一般而言，「片段起點」之設計創造Ncol限制位點，而「片段終點」之設計創造Hindlll限制位點。限制切割反應物係使用Magic DNA Clean-up System套組 (Promega)純化。「片段起點」及「片段終點」係於1%之TAE 凝膠上離析，經溴化乙錠染色，並使用Qiaex Gel Extraction 套組（Qiagen)分離。結合此等片段，並藉於50°C加熱10分鐘，並缓慢冷卻，而使其與PMON3934之〜3800鹼基對 Ncol/Hindlll載體片段之末端黏連。使用T4 DNA稼接酶 φ (Boehringer Mannheim)稼接此三片段。結果係為一含有全長新N-端/C-端基因之質體。以此稼接反應物之部分轉形大腸桿菌 DH5 α 細胞（Life Technologies，Gaithersburg，MD)。純化質體DNA並如下確認其序列。方法III:以串聯-重覆法創造新N-端/C-端基因新N-端/C-端基因可根據述於R. A. Horlick，et al. (Protein Eng· 5:427-431，1992)之方法製備。新N-端/C-端基因之聚合酶連鎖反應（PCR)擴增係使用經串聯重覆之樣板DNA而進 φ 行。此等步驟如圖3所示。串聯重覆之樣板DNA係以選殖產生，且其含有兩基因拷貝（此兩拷貝係以編碼該兩基因拷貝之原始C-及N-端之連接子之DNA序列分隔）。使用特定之引子組以由該串聯重覆之樣板DNA創造並擴增全長之新N-端/C-端基因。此等引子之設計使其包括可將新基因選殖進入表現質體之適當限制位點。典型之PCR條件係1循環之95°C溶解2分鐘；25循環之94°C變性1分鐘，50°C黏連1分鐘，及72°C延伸1分鐘；再 O:\92\92747.DOC -80 - 200413407

加上1循環之72°C延伸7分鐘。使用Perkin Elmer GeneAmp PCR Core Reagents套組（Perkin Elmer Corporation，Norwalk， CT)。100微升之反應物含有各100皮莫耳（pmol)之引子及1 微克之樣板DNA ;以及lx PCR緩衝溶液，200 // M dGTP ，200 // M dATP，200 β M dTTP ^ 200 // Μ dCTP，2.5 單位AmpliTaq DNA聚合酶及2 mM MgC12。PCR反應係於 Model 480 DNA 熱循環儀（Perkin Elmer Corporation， Norwalk，CT)中進行。PCR反應物以 Wizard PCR Preps 套組 (Promega)純化 o 新N-端/C-端基因進入多功能受體促效劑表現載體之選殖以限制核酸内切酶對新N-端/C-端基因進行切割處理，以創造適於將其插入含有另一集落刺激因子基因之表現載體中之終端。此一表現載體亦同樣以限制核酸内切酶進行切割處理，以形成匹配之終端。在純化之後，結合該基因及載體DNA，並使用T4 DNA稼接酶進行稼接。以此稼接反應物之部分轉形大腸桿菌。純化質體DNA並進行定序，以確認正確之插入。培養正確之純系以進行蛋白質表現。 DNA分離及定性質體DNA之分離可以許多熟習此項技術者所知之不同方法，並使用市售可得之套組進行。於此顯示數種此等方法。質體 DNA 係使用 Promega Wizard TM Miniprep 套組 (Madison，WI)、Qiagen QIAwell Plasmid 分離套組 (Chatsworth，CA)或 Qiagen Plasmid Midi套組分離。此等套組皆遵循同樣之一般性流程進行質體DNA分離。簡言之， O:\92\92747.DOC -81 - 200413407 其藉離心（500 x g)沈澱細胞，以後續之NaOH/酸處理釋出質體DNA，並藉離心（10000 X g)除去細胞碎片。將上清液（其含有質體DNA)添加至含有DNA-連結樹脂之管柱上，清洗該管柱，並以TE溶析質體DNA。在篩選帶有目標質體之純系之後，將該大腸桿菌細胞接種至50-1 00毫升添加適當抗生素之LB中，在通氣培養箱中，於37°C下震盪進行隔夜培養。將純化之質體DNA用於進行DNA定序，進一步之限制酶切割處理，DNA片段之進一步次選殖，以及哺乳動物、 φ 大腸桿菌或其他細胞之轉染。序列確認將純化之質體DNA重新懸浮於dH20中，並於Bausch and Lomb Spectronic 601 UV分光計中測量其於260/280 nm之吸收值以進行定量。使用ABI PRISMtm DyeDeoxyTM終端定序化學（Applied Biosystems Division of Perkin Elmer Corporation, Lincoln City，CA)套組（Part Number 403188或 402078)，根據製造商所建議之流程（通常於定序混合物中添 φ 加5%DMSO而修飾），以對DNA樣本進行定序。定序反應係於 Model 480 DNA 熱循環儀（Perkin Elmer Corporation, Norwalk，CT)中，遵循建議之擴增條件進行。以Centri-Sep™ 自旋管柱（Princeton Separations，Adelphia，NJ)純化樣本，除去過量之染劑終止劑，再對樣本進行康乾。將經榮光染劑標記之定序反應物重新懸浮於去離子之甲醯胺中，並於變性4.75%聚丙烯醯胺-8M尿素凝膠上，使用ABI Model 3 73 A自動DNA定序儀進行定序。使用Se quencher DNA分析 O:\92\92747.DOC -82- 200413407 軟體（Gene Codes Corporation，Ann Arbor, MI)分析重疊之 DNA序列片段，並將其組合成為主DNA毗連序列群。多功能受體促效劑於哺乳動物細胞中之表現哺乳動物細胞轉染/條件培養碁之製備 BHK-21細胞系可自ATCC (Rockville，MD)取得。將細胞培養於添加至2 mM (mM) L-然醯胺酸及10%胎牛血清（FBS) 之 Dulbecco’s modified Eagle media (DMEM/高葡萄糖）中。此一調配物稱為BHK生長培養基。選擇性培養基係添加453 單位 / 毫升潮黴素 B (Calbiochem，San Diego，CA)之 BHK 生長培養基。先以HSV反式激活蛋白乂？16穩定轉染811反-21細胞系，該蛋白可反式激活見於質體PMON3359上之IE110啟動子（參見 Hippenmeyer et al·， Bio/Technology， pp, 1037-1041，1993)。VP 16蛋白可驅動插於IE 110啟動子後之基因。表現反式激活蛋白VP 1 6之BHK-2 1細胞系稱為 BHK-VP16。質體 pMON1118 (參見 Highkin et al.，Poultry Sci·，70:97〇-981，1991)自SV40啟動子表現潮黴素抗性基因。亦可自ATCC取得一相似之質體psv-hgh。於轉染前24小時，將BHK-VP1 6細胞播種於60毫米（mm) 之組織培養皿内（每皿3 X 105細胞）。於每皿3毫升含有10微克質體DNA(其含目標基因）、3微克潮黴素抗性質體 pMONl 11 8 及 80 微克 Gibco-BRL nLIPOFECTAMINEn tm之 OPTIMEM tm (Gibco-BRL，Gaithersburg，MD)中，轉染細胞1 6小時。接著吸出該培養基，並以3毫升之生長培養基取代。於轉染後48小時，自各μ收集培養基，並分析其活性（ O:\92\92747.DOC -83 - 200413407 瞬時條件培養基）。以胰蛋白酶-EDTA將細胞由培養皿移除，稀釋1 : 10，並轉移至含有10毫升選擇性培養基之1〇〇毫米組織培養皿中。在置於選擇性培養基中約7天後，抗性細胞可長成直徑數毫米之集落。以滤紙（切成約與該等集落相同之大小，並浸於胰蛋白酶/EDTA中）將該等集落自培養皿移除，並轉移至24孔培養盤上含有1毫升選擇性培養基之各孔中在。亥等純系長至鋪滿之後，重新分析條件培養某，並使陽性純系於生長培養基中進行擴展。多功能受體促效劑於大腸桿菌中之表現於購自 New Brunswick Scientific (Edison，New Jersey)之通氣培養箱Model G25中，在37°C下，於添加水解酸蛋白胺基酸之M9培養基中震盪培養帶有目標質體之大腸桿菌菌株MON105及JM101。以OD600監測生長情形，至其到達1〇之值時，加入在0·1 N NaOH中之莕啶酮酸（10毫克/毫升）至終濃度50微克/毫升。再於37t：下震盪培養物3至4小時。培養期間皆維持高度之通氣，以達成目標基因產物之最大生產。在光學顯微鏡下檢驗細胞内包含體（IB)之存在。取出1 毫升之培養物，煮沸細胞沈積物，以還原緩衝溶液處理之，再經SDS-PAGE電泳，分析培養物中之蛋白含量（參見 Maniatis et al.? Molecular Cloning: A Laboratory Manual, 19 82)。對培養物進行離心（5 000 x g)以沈殿細胞。以包含體之形式累積於大腸桿菌中之多功能鑲嵌造血素受體促效劑之包含體製備、萃取、重折疊、透析、DEAE層析、及定性 O:\92\92747.DOC -84- 200413407 包含體之製備：將取自3 3 0毫升大腸桿菌培養物之細胞沈;殿物重新懸浮於15毫升之超音波緩衝溶液中（10 mM 2-胺基-2-(羥甲基 )-1，3-丙二醇鹽酸鹽（Tris-HCl)，pH 8.0 + 1 mM 乙二胺四乙酉艾（EDTA))。使用 Sonicator Cell Disruptor (Model W_375 Heat Systems-Ultrasonics，Inc·，Farmingdale，New Y〇rk)之微吸頭探針，對此等重新懸浮之細胞進行超音波處理。使用二回之超首波處理（於超音波緩衝溶液中）及後續之離心處理，破壞細胞並清洗包含體（IB)。第一回之超音波處理係一次3分鐘之破壞，再加上一次丨分鐘之破壞，而後兩回之超音波處理則各為1分鐘。取自包含體沈澱物之蛋白質之萃取及重折疊：在終離心步驟後，將IB沈澱物重新懸浮於1〇毫升之5〇 mM Tris-Hcl (pH 9.5)、8 Μ尿素及 5 mM 二硫蘇糖醇（dtt) 中，並於室溫下攪拌約45分鐘，以使經表現之蛋白變性。將萃取溶液轉移至含有70毫升之5 mM Tris_Hcl (ρΗ 9 5) 及2·3 Μ尿素之燒杯中，並於代，接觸空氣緩慢揽掉以至 48小時，以使該蛋白進行重折折疊之監測係於 (Hesperia, Ca.) Cl8反相高效液相層析（Rp_HpLc)管柱上 (0.46 x 25公分）之分析進行。使用含有〇ι%三氣乙酸讲A) 之40%至65%乙腈之線性梯度監測重折疊。此一梯度係於川分鐘間’以母分鐘1 5臺斗 >、、云、A )3 cm 毛升足泥速展開。於該梯度中，變性蛋白一般係在重折疊蛋白之後溶析。純化： O:\92\92747.DOC -85- 200413407 在重折宜之後，以酸沈澱除去污染之大腸桿菌蛋白。使用1 5% (V/V)之乙酸⑽Ac)，將重折疊溶液之pH滴定至介於 pH 5.0及pH 5.2間。於代下，攪拌此溶液2小時，再以12,〇〇〇 X g離心20分鐘，以沈澱任何未溶解之蛋白。使用分子量截斷（MWCO)為 3,500 dah〇ndSpectra/p〇r 3 膜’對取自酸沈殿步驟之上清液進行透析。透析係對抗替換兩次之4升（50-倍過量）1〇mMTris_Hcl(pH8 〇)，以總共 18小時之時間進行。透析可減低樣本之導電性，並可於進行DEAE層析之前除去尿素。在透析之後，再進行離心 (12,000 X g，20分鐘），以沈澱任何未溶解之蛋白。使用Bio-Rad Bio_SCale DEAE2管柱（7 χ 52毫米）進行離子又換層析。該官柱係以含有1〇 mM Tris_Hcl (pH 8〇)之缓衝命液平衡，並於45管柱體積間，使用平衡緩衝溶液中〇_至 500 mM氯化鈉（NaCl)之梯度溶析蛋白。在溶析過程中使用每分叙1 ·0耄升之流速。在該梯度間收集管柱級份（每級份 2.0¾ 升）’並於 Vydac (Hesperia，Ca.) C18 管柱上（〇·46 χ 25 φ 公分）’以RP-HPLC進行分析。使用含有〇1%三氟乙酸（TFA) 之40%至65%乙腈之線性梯度。此一梯度係於3〇分鐘間，以每分鐘1.5耄升之流速展開。再使集合之級份對抗替換兩次之4升（5 0-至-5 00-倍過量）1〇111^乙酸銨（1^4八。）（？114.0)，以總共18小時之時間進行透析。透析係使用mwCO為3,500 daltons之Spectra/P〇r3膜進行。最後，使用〇·22微米之針筒式 /慮备（// Star LB針同式攄器，c〇star，Cambridge，Ma.)對樣本進行無菌過滤，並J宁存於4。〇。 O:\92\92747.DOC -86 - 200413407 在部分情況下，重折疊之蛋白可使用黏連於適當基質上之親和劑（諸如，mAbs或受體次單元）進行親和純化。或者，（或此外）純化亦可使用多種層析法中之任何一種完成，諸如：離子交換、凝膠過濾或疏水層析，或反相HPLC。此等及其他蛋白純化之方法詳述於Method in Enzymology，Volume 182 ’Guide to Protein Purification丨 edited by Murray Deutscher, Academic Press, San Diego, CA (1990) 。 · 蛋白質定性：以RP-HPLC、電喷射質譜、及SDS-PAGE分析經純化之蛋白。蛋白定量係以胺基酸組成、RP-HPLC、及Bradford蛋白測定完成。在部分情況中，其於進行電噴射質譜時，再結合進行tryptic肽作圖，以確認該蛋白之身份。生物活性人類間白素-3之AML增殖分析因子依賴性之細胞系AML 193係取自美國典型培養物收集中心（ATCC，Rockville，MD)。此一細胞系（其係自一患有鲁急性骨髓性白血病之病患建立）係一種因子依賴性之細胞系，其在添加GM-CSF之培養基中展現增強之生長情形 (Lange，B·，et al·，Blood 70:192，1987; Valtieri，M·，et al·， J· Immunol· 138:4042, 1987)。AML 193細胞在人類 IL-3之存在下進行增殖之能力亦已為文獻記載（Santoli，D.，et al.，J. Immunol. 139:348，1987)。使用細胞系變體 AML 193 1.3，其係藉由洗去生長因子，並使細胞因子依賴性之AML 193 細胞在不含生長因子之情形下叙餓培養24小時，而使其成 O:\92\92747.DOC -87- 200413407 為適於在IL-3中進行長期培養者。再於24孔之培養盤上，於含有100 U/毫升IL-3之培養基中，以1 X 1〇5細胞/孔對該等細胞重新進行平板培養。欲使細胞於IL_3中快速成長約 /員2個月之後’藉於培養基中（參見下文）添加人類IL·3，而使此等細胞維持為AML 193 1.3。藉以250 X g離心細胞懸浮液10分鐘，再傾析上清液，於冰 Hanks 平衡鹽溶液（BVSS，Gibco，Grand Island，NY)中清洗AML· 193 1.3細胞6次。將沈澱之細胞重新懸浮於HBBS中，重複該流程，直到完成6次清洗之循環。以介於2 X 105 至5 X 105活細胞/毫升之密度，將以此流程清洗6次之細胞重新懸浮於組織培養基中。此種培養基係將Isc〇ve，s modified Dulbecco’s Medium (IMDM，Hazelton，Lenexa，KS) 添加白蛋白、運鐵蛋白、脂質、及2-鲩基乙醇而製備。牛白蛋白（Boehringer-Mannheim，Indianapolis，IN)係以 5〇〇微克/¾ 升添加；大豆脂（Boehringer-Mannheim，Indianapolis IN)係以5 0微克/毫升添加；而2-巯基乙醇（Sigma，St. Louis， MO)係以5 x 1 〇_ 5 Μ添加。在96孔之Costar 3596組織培養盤中，於如上所述進行添加之組織培養基中，對人類間白素_3或多功能鑲嵌造血素受體促效蛋白進行三重系列之系列稀釋。在完成系列稀釋時’每孔即含有50微升含間白素-3或多功能鑲嵌造血素受體促效蛋白之培養基。控制組試驗孔僅含組織培養基（陰性控制組）。吸取50微升（2.5 X 1〇4細胞）細胞懸浮液注入各試驗孔中，而將如上所述製備之AML 1 93 1 _3細胞懸浮液力口人 O:\92\92747.DOC -88 - 200413407 各孔。將組織培養盤與5% C02，在溼潤空氣中，於37°C下放置3天。在第3天時，將0.5 // Ci之3H-胸苷（2 Ci/mM，New

England Nuclear，Boston，ΜΑ)，於50微升之組織培養基中添加。將培養物與5% C02，在溼潤空氣中，於37°C下放置 18-24小時。使用TOMTEC細胞收集器（TOMTEC，Orange， CT)(其係利用一水清洗循環，皆蓄一70%乙醇清洗循環），將細胞DNA收集至玻璃濾墊上（Pharmacia LKB， Gaithersburg，MD)。通氣乾燥該等濾墊，再將其置入添加 φ 閃爍液（Scintiverse II，Fisher Scientific，St. Louis 或 BetaPlate Scintillation Fluid，Pharmacia LKB，Gaithersburg， MD)之樣本袋中。以LKB BetaPlate model 1205閃爍計數器 (Pharmacia LKB，Gaithersburg，MD)計算取自每一組織培養孔之樣本之/5 -射線發射，並以每分鐘被取自各組織培養孔之細胞納入之3 H-胸苷計數表示數據。藉著量測由層級濃度之間白素-3或多功能鑲嵌造血素受體促效劑謗發之細胞增殖值（3 H-胸嘗之納入），定量各人類間白素-3製備物或多功 | 能鑲嵌造血素受體促效蛋白製備物之活性。一般而言，在此等分析中定量出介於0.05 pM-105 pM之濃度。活性係由量測可提供50%最大增殖值之間白素-3或多功能鑲嵌造血素受體促效劑之劑量（EC5G = 0.5 X (所有受試間白素-3濃度之三重試驗培養物之每孔每分鐘納入之3 H-胸苷之最大平均計數-由在不含間白素-3之三重培養物中所見之3H-胸苷納入計數所測得知背景增殖值））而進行測定。EC5()值亦等於1單位之生物活性。以天然間白素-3進行每一分析作為參 O:\92\92747.DOC -89- 200413407 考標準值，以指定相對活性強度。一般而言，多功能鑲嵌造血素受體促效蛋白係以介於 2000 pM至0_06 pM之濃度（其係以系列之2倍稀釋進行測定）進行試驗。每一樣本之活性係將一種四參數邏輯模型套用於數據上，而以可提供50%最大反應值之濃度測定。咸觀察到樣本及用以進行比較之標準品之上方平台值（最大反應值）並無差異。因此，每一樣本之相對強度計算值係由樣本及如上 $ 所述之標準品之EC50估計值測定。AML 193.1.3細胞對 hIL-3、hGM-CSF、及hG-CSF產生反應而增殖。因此對部分樣本進行下述之其他分析，以證明多功能鑲嵌造血素受體促效蛋白之G-CSF受體促效劑部分係具有活性者。增殖分析係以多功能鑲嵌造血素受體促效劑加減對抗hIL-3受體促效劑部分之中和單株抗體而進行。此外，亦對具有因子 Xa切割位點之融合分子進行切割及純化，並分析該分子各半部份之增殖活性。此等實驗顯示該多功能鑲嵌造血素受籲體促效蛋白之兩組成分皆具有活性。 TF1 c_mpl配位體依賴性增殖分析 c-mpl配位體增殖活性可使用多能性人類細胞系TF1 (Kitamura et al·，J. Cell Physiol. 140:323酿334，[1989])之一種次純系進行分析。TF1細胞係維持於h-IL3 (100 U/毫升）中。為建立可對c-mpl配位體產生反應之次純系，其將細胞維持於含有10%取自經表現c-mpl配位體之1-1 53形式之基因（pMON26448)轉染之BHK細胞之上清液之傳代培養基中 O:\92\92747.DOC -90- 200413407 。大部分之細胞皆死亡，但有一次群之細胞存活。在稀釋選殖後，篩選出一種c-mpl配位體反應性純系，而在進行分析前一天，先將此等細胞以0.3 X 106細胞/毫升之密度分至傳代培養基中。此等細胞之傳代培養基係如下所列：RPMI 1640 (Gibco)，10% FBS (Harlan，Lot #91206)，10%取自經轉染BHK細胞之c-mpl配位體上清液，1 mM丙酮酸鈉（Gibco) ，2 mM麩醯胺酸（Gibco)，及100微克/毫升之青黴素-鏈黴素 (Gibco)。第二天，收集細胞，並於RPMI或IMDM培養基中清洗細胞兩次，再於ATL，或分析培養基中進行最後一次之清洗。ATL培養基係由下列成分組成：每1〇〇〇毫升之ATL 中，含IMDM(Gibco)，500微克/毫升之牛血清白蛋白，：[〇〇微克/毫升之人類運鐵蛋白，50微克/毫升之大豆脂，4 X 10-8M之/3-筑基乙醇’及2¾升之A9909 (Sigma，抗生素溶液）。在96孔之低蒸發性培養盤（c〇star)中，以分析培養基稀釋細胞至0.25 X 1〇6細胞/毫升之終密度，終體積為5〇微升。以5 0微升之體積’將取自經轉染純系之瞬時上清液（條件培養基）添加至50%之終濃度（二重樣本），並稀釋3倍至1.8〇/。之終稀釋濃度。亦包括IL_3變體pMON13 28 8劑量曲線（其起自1納克（ng)/毫升，並使用3倍稀釋處理稀釋至〇〇〇14納克/ 毫升）之三重樣本作為陽性控制組。將培養盤置於5% c〇2 及37C下。在培養第6天時，以〇_5 Ci之3H/孔（NEN)，於20 械升/孔之ta %對该培養盤進行脈沖，並使其置於$ % 〇及37 C下4小時。收集培養盤，並於Betapiate計數器中進行計數。 200413407 MUTZ-2細胞增殖分析諸如MUTZ-2 (其為人類骨髓性白血病細胞系（德國微生物及細胞培養物收集中心，DSM ACC 271))之細胞系可用於測定flt3受體促效劑之細胞增殖活性。MUTZ-2培養物係與重組天然flt3配位體（20-100納克/毫升）共同維持於生長培養基中。在進行分析前18小時，在ime>m培養基（Gibco) 中清洗MUTZ-2細胞三次，以0.5_〇·7 x 1〇E6細胞/毫升之濃度重新懸浮於IMDM培養基中，再將其置於37。〇及5% c〇2 下’以使細胞在缺乏flt3配位體之情形下進行飢餓培養。進行分析當天，在經無菌組織培養物處理之96孔培養盤中，以刀析培養基，將標準品及受體促效劑稀釋至高於目標終濃度兩倍之濃度。以三重試驗對fh3受體促效劑及標準品進行實驗。將50微升之分析培養基加入除八排外之所有試驗孔中。將75微升之fit3受體促效劑或標準品加入A排中，同時，由該排取出25微升，並於培養盤上其他之部分（B至〇排）進行系列稀釋（1:3)。Η排維持為僅含培養基之控制組。在IMDM培養基中清洗經飢餓處理之MUTZ-2細胞兩次，並舲其重新懸浮於5〇微升之分析培養基中。將5〇微升之細胞加至各孔中，造成〇·25 X 10E6細胞/毫升之終濃度。將含有細胞又分析培養盤置於37°C及5% (：〇2下44小時。以丄"ci/ 孔之氚化胸苷，於2〇微升/孔之體積對該培養盤進行脈沖4 小時。收集培養盤並進行計數。其他基於細胞之活體外增殖分析根據構成分子之因子，亦可以類似述於AML 細胞

O:\92\92747.DOC -92- 200413407 增殖分析中之方式，使用其他熟習此項技術者所知之基於細胞之活體外分析，測定多功能鑲嵌造血素受體促效劑之活性。下列為其他可用分析之例·· TF1增殖分析：TF1係一多能性人類細胞系（Kitamwa al·，J. Cell Physiol. 140:323-334, [1989])，其可對 hIL_3 產生反應。 32D增殖分析：32D係一鼠類比」依賴性細胞系，其不對人類IL-3產生反應，但可對非為種類限制性之人類g_csf 產生反應。

Baf/3增殖分析：Baf/3係一鼠類比-3依賴性細胞系，其不對人類IL-3產生反應，但可對非為種類限制性之人類g_csf 產生反應。 T11 65增殖分析·· T11 65細胞係一 il-6依賴性之鼠類細胞系（Nordan et al·，1986)，其可對IL-6及IL-11產生反應。人類血漿凝血meg-CSF增殖分析：用於分析巨核細胞集落形成活性（Mazur et al.，1 981)。經轉染細胞系：細胞系（諸如鼠類Baf/3細胞系）可經該細胞系所不含之集落刺激因子受體（諸如人類G-CSF受體或人類c_mpl受體）轉染。此等經轉染之細胞系可用於測定該已轉染進入該細胞系中之受體之配位體的活性。此種經轉染Baf/3細胞系之一之製備可藉由將編碼c-mpl 之cDNA，由一自c-mpl反應性細胞系製得之基因庫中選殖出來’並將其選殖進入質體pcDNA3 (Invitrogen，San Diego, O:\92\92747.DOC -93 - 200413407

Ca·)之多重選殖位點中而進行。使用電穿孔法，以該質體轉染Baf/3細胞。在小鼠IL_3之存在下，於Wehi條件培養基中，使該等細胞在G418篩選下進行生長。經由限制稀釋建立純系。以類似之方法’亦可將人類G_CSF受體轉染進入Baf/3細胞系中，並將其用於測定多功能鑲嵌造血素受體促效劑之生物活性。 c _ m p 1配位體增殖活性之分析方法 1.骨髓增殖分析 a. CD34 +細胞純化：在提供者之同意之下，自正常之同種異型骨髓提供者取得骨髓抽出液（15-20毫升）。於磷酸鹽緩衝鹽溶液中（pbs， Gibco-BRL) ’以1 ·· 3稀釋細胞，使30毫升之細胞溶液於15 毫升之Histopaque-1077 (Sigma)間進行分層，並於以300 RCF離心30分鐘。收集單核界面，並以PBs清洗。使用親和管柱，根據製造商之指示（CellPro, Inc.，Bothell，WA)，自該單核細胞製備物中富集CD34+細胞。在富集處理後， CD34 +細胞之平均純度係為70% (其係利用流式細胞計量分析法’使用與螢光素綴合之抗-CD34單株抗體及與藻紅蛋白經合之抗 _CD38 (Becton Dickinson，San Jose，CA)進行測定）。將細胞以40,000細胞/毫升之濃度重新懸浮於x_viv0 1〇培養基中（Bio-Whittaker，Walkersville，MD)，並將 1 毫升於 12孔組織培養盤中（Costar)進行平板培養。在部分試驗孔中 O:\92\92747.DOC -94- 200413407 ，以100納克/毫升之濃度，加入生長因子rhIL-3 (pM〇N5873) 。以10納克/毫升至100納克/毫升之濃度使用hIL3變體。將 100微升之上清液加入1毫升之培養物（約10%之稀釋），對取自經編碼c-mpl配位體或多功能鑲嵌造血素受體促效劑之質體轉染之BHK細胞之條件培養基進行試驗。在37°C之溼潤培養箱中，將細胞在5% C02中置於3 7。(：下8-14天。 b.細胞收集及分析：在培養期結束之時，取得每一條件下之總細胞計數。為進行螢光分析及ploidy測定，其以巨核細胞缓衝溶液（MK緩衝溶液，13.6 mM檸檬酸鈉，1 mM茶鹼，2.2/z M PGE1，11 mM葡萄糖，3% w/v BSA，於PBS 中，pH 7·4) (Tomer et al·，

Blood 70:1735-1742，1987)清洗細胞，將細胞重新懸浮於 500 微升含有抗-CD41a FITC 抗體（1:200, AMAC，Westbrook， ME)之MK缓衝溶液中，並於MK緩衝溶液中清洗。為進行 DNA分析，其在冰上，於含有 0.5% Tween 20 (Fisher，Fair Lawn，NJ)之MK緩衝溶液中，對細胞進行20分鐘之透化處 | 理，再於 0.5% Tween-20及 1 %低聚甲酸（Fisher Chemical)中，進行30分鐘之固定處理，再接著使其在二碘化丙錠中 (Calbiochem，La Jolla，CA)(5 0微克/毫升），與 55% v/v之 MK 緩衝溶液中（200 m Os m)之RN A酶（400 U/毫升）於冰上共置 1 - 2小時。於FACS can或Vantage流式細胞計量儀（Beet on Dickinson，San Jose，CA)中分析細胞。收集綠色勞光 (CD41a-FITC)，以及紅色螢光（PI)之線性及對數信號，以測定DNA ploidy。收集所有細胞以測定CD41 +細胞之百分比 O:\92\92747.DOC -95- 200413407 。使用 LYSIS 軟體（Becton Dickinson，San Jose，CA)進行數據分析。自流式細胞計量分析取得表現CD41抗原之細胞百分比（Percent)。每毫升之CD41 +細胞之絕對（Abs)數目係以下式計算··（Abs)=(細胞計數）X (Percent) / 1 00。 2.巨核細胞血纖維蛋白凝血分析如上所述分離CD34+富集細胞群。將細胞以25,000細胞/ 毫升之濃度，在有及無細胞因子之情形下，懸浮於培養基中，該培養基係由基礎之Isc〇ves IMDM培養基，添加0.3% BSA，0.4毫克/毫升之脫鐵運鐵蛋白，6.67 // M FeC12，25 微克/毫升之CaCl2, 25微克/毫升之L-天冬胺酸，500微克/ 毫升之e-胺基-η-己酸，及青黴素/鏈黴素而構成。在於35毫米之培養平板上進行平板培養之前，添加凝血酶（〇 · 2 5單位/ 毫升）以起始凝血塊之形成。在37°C之溼潤培養箱中，使細胞在5% C02中置於37°C下13天。在培養期結束之時，以甲醇：丙酮（1:3)固定培養平板，通氣乾緣’並如存於-2 0 C直到進行染色。利用過氧化物酶免疫細胞化學染色法（Zymed，Histostain-SP，San Francisco, CA)，使用由抗-CD41a、CD42及CD61構成之初級單株抗體混合物。在染色之後對集落進行計數，並將其分類為陰性、CFU-MK (小型集落，1-2焦點，且少於約25細胞）、BFU-MK( 大型，多焦點之集落，具有大於25細胞）、或混合集落（陽性及陰性細胞之混合物）。甲基纖維素分析此一分析可反應集落刺激因子在活體外刺激正常骨髓細 O:\92\92747.DOC -96- 200413407 胞生產不同種類之造血細胞集落之能力（Bradley et al.5 A list. Exp. Biol. Sci. 44:287-300, 1966; Plunzik et al.? J. Cell Comp. Physio. 66:319-324，1965)。方法在個體對象同意之下，自其體内取得約3 〇毫升新鮮、正常、健康之骨髓抽出液。在無菌條件下，使用1X PB s溶液 (#14040.059 Life Technologies，Gaithersburg，MD·)，在 50 毫升之錐形管中（#25339-50 Corning，Coming，MD)，以 1 : 5 稀釋細胞。使Ficoll (Histopaque 1077 Sigma H-8 8 89)於經稀釋樣本中分層，並以3〇〇 x g離心3〇分鐘。取出單核細胞條帶，並以IX PBS清洗兩次，再以1% BSA PBS (CellPr〇 c〇.， Bothel，WA)清洗一次。對單核細胞進行計數，並使用

Ceprate LC (CD3 4)套組（CellPro Co·，Bothel，WA)管柱篩選出CD34+細胞。進行此一分級分層，因所有之骨髓中之幹細胞及組細胞皆具有CD34表面抗原。使用二重试驗，以1. 〇毫升之終體積，於3 5 X 1 〇毫米之培養狐（Nunc#!74926)中進行培養。培養基係購自Terry f⑽ Labs· (HCC-4230 培養基（Terry F〇x Labs，Vanc ⑽ b c，

Canada))，且在該培養基中添加紅血球生成素叫⑶， Thousand Oaks，CA.)。在每皿中加入3,〇〇(M〇,〇〇〇 +細肊加入重、，且IL~3 (其係由哺乳動物細胞或大腸桿菌純化）及多功能鐵嵌造血素受晋#代二々疋^^+ 于又促效蛋白（其係存在於取自經轉染之哺乳動物細胞之條件拉1^ ^ , < V、忏培養基中，或自取自經轉染之哺乳動物細胞或大腸桿菌泛体ip #甘+ ^ 卞囷足知件培養基中純化），以提供β00!

O:\92\92747.DOC -97- 200413407 nM至10 nM不等之終濃度。重組hIL-3、GM-CSF、c-mpl配位體、及多功能鑲嵌造血素受體促效劑係由實驗室内提供。G-CSF (Neupogen係取自 Amgen (Thousand Oaks，Calf.)。使用3cc之針筒重新懸浮培養物，並於每皿分液1.〇毫升。控制組（基線反應）培養物並未添加任何集落刺激因子。陽性控制組培養物添加條件培養基（經ΡΗΑ刺激之人類細胞： Terry Fox Lab. Η2400)。將培養物於溼空氣中，置於37。〇， 5% C02下。在峰反應當天（第10-11天），使用具有40x物鏡組合之 Nikon倒相顯微鏡，對定義為大於5 〇細胞之造血細胞集落進行計數。含有少於50細胞之細胞群稱為簇。或者，可將集洛豐佈於玻片上’再加以染色以進行辨識，或可挑取集落，重新懸幅，並離心至細胞自旋玻片上以進行染色。人類臍帶血造血生長因子分析傳統上係使用骨髓細胞進行造血細胞集落刺激刺激因子 (CSF)活性之活體外分析。然而，並非總可取得人類骨髓，且在不同之提供者間，具有相當程度之差異性。在作為造血幹細胞及組細胞之來源方面，臍帶血可與骨髓相當 (Broxmeyer et al.5 PNAS USA 89:4109-113, 1992; Mayani et al·，Blood 81:3252-3258, 1993)。相對於骨髓，臍帶血較易以一般性足基礎取得。其亦可藉集合自不同提供者新鮮取得之細胞而減少分析變異性，或為此目的而創造一批冷凍保存足細胞藉由修飾培養條件，及/或分析譜系專一性之標記物，可對粒細胞/巨噬細胞集落（cfu_gm)、巨核細胞 O:\92\92747.DOC -98- 200413407 活性、或高度增殖性之潛力集落形成細胞（HPP-CFC)活性進行專一性之分析。方法使用標準密度梯度（1.077克/毫升之Histopaque)，在收集臍帶血後24小時之内，由臍帶血中分離單核細胞（MNC)。臍帶血MNC已經數種流程，對幹細胞及組細胞進行進一步之富集，包括CD 14-、CD34 +細胞之免疫磁性篩選；使用取自 Applied Immune Science (Santa Clara，CA)之經塗覆三角 _ 瓶所進行之SBA-、CD34+分層部分淘選；以及使用CellPro (Bothell，WA)之親和素管柱所進行之CD34+篩選。使用新鮮分離或冷凍保存之CD34+細胞富集分層部分進行分析。以1 X 104細胞，在1毫升含0.9%甲基纖維素，未添加生長因子培養基中（Methocult H4230，取自 Stem Cell Technologies， Vancouver，BC.)，對每一樣本之系列稀釋（濃度介於1 pM至 1204 pM不等）製備二重培養物。在部分實驗中，其使用含有紅血球生成素（EPO)之Methocult H4330取代Methocult · H4230，或添加50納克/毫升之幹細胞因子（SCF) (Biosource International，Canarillo，CA)。在培養 7-9 天後，對含有大於 30細胞之集落進行計數。為在評分時去除主觀之偏見，分析係以盲拭方式進行評分。有關可用於創造變體之重組DNA法，在細菌、哺乳動物細胞、或昆蟲細胞中對其進行表現，純化及重折疊目標蛋白，以及用以測定該等蛋白生物活性之分析之其他細節可見於同一申請人之專利申請案WO 95/00646、WO 94/12639 O:\92\92747.DOC -99- 200413407 、WO 94/12638、WO 95/20976、WO 95/21 197、WO 95/20977 、WO 95/21254及US 08/383,035，其全文皆併入本文作為參考文獻。熟習此項技術者所知之其他細節可見於T. Maniatis，et al.，Molcular Cloning，A Laboratory Manual, Cold Spring Harbor Laboratory，1982及其中所引述之參考文獻，其併入本文作為參考文獻，以及J· Sambrook，et al·，Molecular Cloning，A Laboratory Manual，2nd edition, Cold Spring Harbor Laboratory，1989及其中所引述之參考文獻，其併入本文作為參考文獻。 O:\92\92747.DOC -100- 200413407

表1 一芬酸（SEQ ID =序列编號） 5 ^mpTNcoI ACGTCCATGGCNTCNCCNGCNCCMCCTGCTTGTGCACTCCGAGTC SEQ ID NO:317 N=A,C,G or T 10 15 20 25 30

Ecompl ATGCACGAATTCCCTGACGCAGAGGGTGGA SEQ ID NO :318 c-mplHindlll TGACAAGCTTACCTGACGCAGAGGGTGGACCCT SEQ ID NO:319 i 4L-5 x AATTCGGCAA SEQ ID NO:3 20 4L-3' CATGTTGCCG SEQ ID NO :3 21 5L-5 ; AATTCGGCGGCAA SEQ ID NO: 3 22 5L-3 ; CATGTTGCCGCCG SEQ ID NO :3 23 3L-5' AATTCGGCGGCAACGGCGGCAA SEQ ID NO:324 8L-3 f CATGTTGCCGCCGTTGCCGCCG SEQ ID NO:32 5 31-5’ CGATCCATGGAGGTTCACCCTTTGCCT SEQ ID NO :326 31-3 ^ GATCAAGCTTATGGGCACTGGCTCAGTCT SEQ ID NO：3 2：T 35-5 ; CGATACATGTTGCCTACACCTGT'CCTG SEQ ID NO:328 35-3 ; GATCAAGCTTAAGGGTGAACCTCTGGGCA SEQ 工D M〇:329 39-5# CGATCCATGGTCCTGCTGCCTGCTGTG SEQ ID NO:330

35 40 45 50 60 65 70 39-3 # GATCAAGCTTAAGGTGTAGGCAAAGGGTG SEQ ID N〇：331 43-V CGATCCATGGCTGTGGACTTTAGCTTGGGA SEQ ID NO:3 32 43-3 # GATCAAGCTTAAGGCAGCAGGACAGGTGT SEQ ID NO :333 CGATCCATGGACTTTAGCTTGGGAGAA SEQ ID NO:334 45-3 f GATCAAGCTTACACAGCAGGCAGCAGGAC SEQ ID NO:335 49-5* ^ CGATCCATGGGAGAATGGAAAACCCAG SEQ ID NO :336 49-3 f GATCAAGCTTACAAGCTAAAGTCCACAGC SEQ 工D N〇：3 37 32-5 , CGATCCATGGGACCOACTTGCCTCTCA SEQ ID NO :338 32-3' GATCAAGCTTACAGTTGTCCCCGTGCTGC SEQ ID NO:339 109-5 f CAGTCCATGGGAACCCAGCTTCCTCCA SEQ ID NO:3 40 109-3( GATCAAGCTTAAAGGAGGCTCTGCAGGGC SEQ ID MO:341 116-5; CGATCCATGGGCAGGACCACAGCTCAC SEQ ID NO:342 116-3 * GATCAAGCTTACTGTGGAGGAAGCTGGGTT SEQ ID NO:343 120-5( CGATCCATGGCTCACAAGGATCCCAATGCC SEQ ID NO:344 !二0-3' GATCAAGCTTATGTGGTCCTGCCCTGTGG SEQ ID W: 345 123-5( CGATCCATGGATCCCAATGCCATCTTCCTG SEQ ID MO :346 t-3-3 , GATCAAGCTTACTTGTGAGCTGTGGTCCT SEQ ID NO:347 1.2 6 - 5 , CGATCCATGGCCATCTTCCTGAGCTTCC.^ SEQ ID MO :348 125-3 ' GATC^nGCTT.\-\TTCGGATCCTTGTGAGCTGT SEQ ：0 NO: 3 49 SYNNO；^l.R£q .^TTCCSTCG T.\.^ACTGACC TTCTATCTGA .-AACCTTGGA GAACGCGCAG GCTCAACAGT ACGTAGAGGG CGGTGGAGGC TCC SEQ ID NO :350

O:\92\92747.DOC -101 - 200413407 S丫NNOKA2·R£Q CCGGGGAGCC TCCACCGCCC TCTACGTACT GTTGAGCCTO CGCGTTCTCC PsAGGTTTTCA GATAGAAGGT CAGTTTACGA • CGG SEQ ID MO：351 10

Llsyn. for GTTACCCTTG AGCAAGCGCA GGAACAACAG GGTGGTGGCT CTAACTGCTC TATAATGAT SEQ ID NO :3 5 2 Lis'/n . rev CGATCATTAT AGAGCAGTTA GAGCCACCAC CCTGTTGTTC CTGCGCTTGC TCAAGG SEQ ID NO:353 15 20 25 30 L3syn.for GTTACCCTTG AGCAAGCGCA GGAACAACAG GGTGGTGGCT CTGGCGGTGG CAGCGGCGGC GGTTCTAACT GCTCTAT.^T GAT SEQ ID NO：354 L3syn.rev CGATCATTAT AGAGCAGTTA GAACCGCCGC CGCTGCCACC GCCAGAGCCA CCACCCTGTT GTTCCTGCGC TTGCTCAAGG SEQ ID NO:355 35start.seq GATCGACCAT GGCTCTGGAC CCGAACAACC TC SEQ ID NO：356 24rev.seq CTCGATTACG TACAAAGGTG CAGGTGGT SEQ ID NO :357 70start.seq GATCGACCAT GGCTAATGCA TCAGGTATTG AG SEQ ID NO：358 69rev.seq CTCGATTACG TATTCTAAGT TCTTGACA SEQ ID NO：359 9Istart.seq, GATCGACCAT GGCTGCACCC TCTCGACATC CA SEQ ID NO：360 90rev.seq CTCGATTACG TAGGCCGTGG CAGAGGGC SEQ ID NO:361 iOistare · seq GATCGACCAT GGCTGCAGGT GACTGGCAAG AA SEQ ID NO :3-62 iOOrev.seq CTCGATTACG TACTTGATGA TGATTGGA SEQ ID NO：363

35 L-Ustart . seq GCTCTGAGAG CCGCCAGAGC CGCCAGAGGG CTGCGCAAGG TGGCGTAGAA CGCG SEQ ID MO:364 40 45 50 60 65 70 L-IisLop.seq CAGCCCTCTG GCGGCTCTGG CGGCTCTCAG AGCTTCCTGC TCAAGTCTTT AGAG SEQ 1^· NO： 3 65 P-blscart: . seqGGGCTGCGCA AGGTGGCG SEQ ID MO: 3 66 P-blstop.seq ACACCATTGG GCCCTGCCAG C SEQ ID NO:367 39scarc.seq GATCGACCAT GGCTTACAAG CTGTGCCACC CC SEQ ID NO:368 38st:op.Seq CGATCGAAGC TTATTAGGTG GCACACAGCT TCTCCT SEQ ID NO ： 359 97start: . seq GATCGACCAT GGCTQCCGAG TTGGGTCCCA CC SEQ ID MO : 3 7.0 35scop .Seq CGATCGAAGC TTATTAGGAT ATCCCTTCCA GGGCCT SEQ ID NO :371 ：26scarc.〇eq GATCGACCAT GGCTATGGCC CCTGCCCTGC AG SEQ ID MO :372 L25sccp.Seq CGATCGAAGC TTATTATCCC AGTTCTTCCA TCTGCT SEQ ID MO :37 3 I33star^.seq GATCGACCAT GGCTACCCAG GGTGCCATGC CG SEQ ：D MO :374 ：32sn〇p.seq CGATCGAAGC TTATTAGGGC TGCAGGGCAG GGGCCA 5HQ ID NO：375 ；42scart.GATCGACCAT GGCTTCTGCT TTCCAGCGCC GG SEQ ID NO:37〇 L-lisccp . Seq '：3ATCG.^GC TTATTAGGCG .-.AGGCCGGCA TGGCAC SEQ ID NO： 377 3LY：<A1 · GTAGAGGGCG GTGGAGGCTC C SEQ ID NO :373 GLYXA2 CCGGGGAGCC TCCACCGCCC TCTAC SEQ ID MO： 3 T 9 1 〇 ί o r TTCTACGl.CΛ CCTTGCGCAG CCCGGC^jGCC v ’ GTCTACACCA TTG 3E：Q ：D MO: 330

L L , C. . ό . .-λ r\L· r\ Γ sj 4 ^ .-tG ·Ό匕、l AGGTGGCGTA SEQ ID NO ： 33 L NCQr LT CTCACCATGGCMACCCAGGACT3CTCCTTCC.\A 3EQ [C NO ： d07

O:\92\92747.DOC -102- 200413407

HIND160 HIND165 5 FL23For FH3AFor SC?. REV)0 39FGR 3 9 REV 15 65FOR 5 5 REV 3 9 FOR20 3 9 REV ACTGPvAGCTTAGGGCTGACACTGCAGCTCCAG SEQ ID NO : 303 ACTP^GCTTACAGGGTTGAGGAGTCGGGCTG SEQ ID NO :809 GACTGCCATGGCNACYCAGGAYTGYTCYTTYCAACACAGCCCCATC SEQ ID NO: 310 GACTGCCATGGCMACYCAGGAYTGYTCYTTYC.\ACACAGCCCCATC SEQ ID MO :811 TGTCCAAACTCATCAATGT.VTC SEQ ID N〇r'd’12 CATGGCCATGGCCGACGAGGAGCTCTGCGGGGGCCTCT SEQ ID NO:813 GCTAGAAGCTTACTGCAGGTTGGAGGCCACGGTGAC SEQ ID NO :814 CATGGCCATGGCCTCCAAGATGCAAGGCTTGCTGGAGC SEQ ID NO： 815 GCTAGA^.GCTTACCCAGCGACAGTCTTGAGCCGCTC SEQ ID MO :816 CATGGCCATGGCCCCCCCCAGCTGTCTTCGCTTCGT SEQ ID NO：317 GCTAG.\AGCTTAGGGCTGAAAGGCACATTTGGTGACA S£Q ID NO: 818

L5A 25 LI0A

L15A30 L5S L10B35 L15B L15C40 L15D L15E45 339FOR2 339REV2 50 339-10FOR3 339-15FQR2 • 339REV3 FLM3 r LN760 FLMll

65 70 FLC3 FLC·； F L Γ 1 0 CCCTGTCTGGCGGC.\ACGGCACCCAGGACTGCTCCTTCCAAC SEQ ID NO: 319 GCGGTAACGGCAGTGGAGGTAATGGCACCCAGGACTGCTCCTTCCAAC SEQ ID NO：8 2 0 ACGGCAGTGGTGGCAATGGGAGCGGCGGAAATGGAACCCAGGACT GCTCCTTCCAAC SEQ ID MO:321 GTGCCGTTGCCGCCAGACAGGGTTGAGGAGTCGGGCTG 3EQ ID NO:322 ATTACCTCCACTGCCGTTACCGCCTGACAGGGTTGAGGAGTCGGG CTG SEQ ID iMO :823 GCTCCCATTGCCACCACTGCCGTTACCTCCAGACAGGGTTGAGGA GTCGGGCTG SEQ ID NO:324 GATGAGGATCCGGTGGCAATGGGAGCGGCGGAAATGG.^ACCCAGG ACTGCTCCTTCCACC SEQ ID MO：325 GATGACGGATCCGTTACCTCCAGACAGGGTTGAGCtAGTCGGGCTG SEQ ID NO :826 GATGACGGATCCGGAGGTAATGGCACCCAGGACTGCTCCTTCC.\AC SEQ ID MO :82 7 GACTGCCATGGCCGACGAGGAGCTCTGCG SEQ ID NO:823 GACTC.-AGCTTACTGCAGGTTGGAGGCC SEQ ID NO :329 GACTCGGGATCCGGAGGTTCTGGCACCCAGGACTGCTCC SEQ ID MO :830 GACTGGGATCCGGTGGCAGTGGGAGCGGCGGATCTGG.^CC SEQ ID NO: 331 GACTTGGGATCCACTACCTCCAGACAGGGTTGAGGA GTC SEQ ID MO :3 3 2 ACTGACGGATCCACCGCCCAGGGTTGAGGAGTCGGGCTG SEQ ID NO：933 ACTGACGGATCCACCTCCTGACCCACCGCCCAGGGTTGAGGAGTCGGGCTG SEQ 13 MO :334 ACTGACGGATCCACCTCCTGACCCACCTCCTGACCCACCGCCCAG GGTTGAGGAGTCGGGCTG SEQ ID MO :335 ACGTAAAGCTTACAGGGTTGAGGAGTCG SEQ ID MO :3 3 6 GTCAGTGGATCCGGAGGTACCCAGGACTGCTCCTTCCA.^ C 5£Q ID MO :337 GTCPvGTGGATCCGGAGGTGGCACCCAGGACTGCTCCTTCC^C SEQ ID MO :838 TCAGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCnG GACTGCTCCTTCC.\AC SEQ ID MG：B29

TAGTCCATGGCCACCCAGGACTGCTCC SEQ ID NO :8 40 GCATTACGTAGGGCTGACACTGCAGCTCCAG SEQ IC NO :841

O:\92\92747.DOC -103 - 200413407

13 9. rev GCATTACGTACAGGGTTGAGGAGTCGGGCTG ScQ ID MO :842 Fl29f〇r 5 FL29rev GTCAGACCATGGCCGATTACCCAGTCACCGTGGCCTC SEQ ID NO：343; TCTGAC.^AGCTTATTG^GCAGGTAGTCAGACAGCTCAC SEQ ID NO: 844; FL3 5 for GTCAGCCCATGGCCGCCTCCAACCTGCAGGACGAGGA SEQ ID MO :845; 10 rL3 5 rev TCTGACAAGCTTACACGGTGACTGGGTAACTTGAAGC SEQ ID NO： 346; FL63for GTCAGACCATGGCCGTCGCTGGGTCCAAGATGCAAGGC SEQ ID M〇：847; FL63rev 15 FL95for TCTGAC.\AGCTTAAGTCTTGAGCCGCTCCATCCAGCG SEQ ID NO :348; GTCAGACCATGGCCCGCTTCGTCCAGACCAACATCTCC SEQ ID MO :349; F L95i：3V TCTGACAAGCTTAAAGACAGCTGGGGGGGGGCTGAA SEQ ID NO:350; 20 FL99for GTCAGACCATGGCCACCAACATCTCCCGCCTCCTGCAG SEQ ID MO:351; FL9 9 rev CTCGACAAGCTTACTGGACGAAGCGAAGACAGCTGGG SEQ ID NO :852; FLTAFL31 25 FLTRIN GATCACATGTCTACAAATCAAGATCTGCCTGTG SEQ ID NO :853 GATCGAATTCGTTGTCTTGGATGAAAGGGA SEQ ID NO :854 HGCFOR ACTTGAATTCATCATCCTGGGCCTGTTCGGGC SEQ ID NO：855 30 HGCREV ACTCAAGCTTAGAAGCTCCCCAGCGCCTCC SEQ ID N〇：856 FL29FOR GTCAGACCATGGCCGATTACCCAGTCACCGTGGCCTC S£Q ID MO :3 82 FL35FOR 35 FL63FOR GTCAGCCCATGGCCGCCTCCAACCTGCAGGACGAGGA SHQ ID MO：383 GTCAGACCATGGCCGTCGCTGGGTCCAAGATGCAAGGC SEQ ID MO： 3 34 FL95FOR GTCAGACCATGGCCCGCTTCGTCCAGACCAACATCTCC SHQ ID NO：335 40 FL99FOR GTCAGACCATGGCCACC.^ACATCTCCCGCCTCCTGCAG SEQ ID MO :3 36 FL29REV TCTGACAAGCTTATTGAAGCAGGTAGTCAGACAGCTCAC SEQ ID NO:387 45 FL35RSV TCTGAC^AGCTT>.CACGGTGACTGC-GTAATCTTGAAGC SEQ ID MO :388 FL62 REV TCTGACAAGCTTAAGTCTTGAGCCGCTCCATCCAGCG SEQ ID MO :389 89 REVSTO? 50 GTCAAGAAGCTTACGGCTGAAAGGCACATTTG SEQ ID MO：390 TCTGACAAGCTTAAAGACAGCTGGGGGGGGGCTGAA SEQ ：D MO :3 91 FL99REV CTCGACA^*GCTTACTGGACGAAGCGAAGACAGCTGGG SEQ ID MO： 3 92 55 Flt36 GTTGCCATGGCNTCNAAYCTGCARGAYGARGARCTGT GCGGGGGCCTCTGGCGGCTG SEQ ID NO：393 GTTGCCATGGC?I^j\YCTGCARGAYGARGARCTGTGYG GGGGCCTCTGGCGGCTGGTC SEQ ID NO：394 60 F i匕Π GTTGCCATGGCNCTGCARGAYGARGARCTGTCYGGYG GCCTCTGGCGGCTGGTCCTG SEQ ID NO:395 Fit:39 GTTGCCATGGCNCARGAYGARGARCTGTGYGGYGGYC O:\92\92747.DOC -104- 200413407

Flt:40 - TCTGGCGGCTGGTCCTGGCA SEQ ID MO：396 GTTGCCATGGCNGAYGARGARCTGTGYGGYGGYCTCT GGCGGCTGGTCCTGGCACAG SEQ ID NO:397 Flt41 GTTGCCATGGCNGARGARCTGTGYGGYGGYCTCTGGC GGCTGGTCCTGGCACAGCGC SEQ ID NO：393 Flt42 10 GTTGCCATGGCNGARCTGTGYGGYGGYCTGTGGCGYC TGGTCCTGGCACAGCGCTGG SEQ ID M〇：399 FIt43 GTTGCCATGGCNCTGTGYGGYGGYCTGTGGCGYCTGG TCCTGGCACAGCGCTGGATG SEQ ID NO：400 15 40 COLI GTTGCCATGGCWGATGAAG.\ACTGTGTGGMGGNCTGTGGCGG SEQ ID MO:401 3 6 REV 20 TATGCAAGCTTAGGCCACGGTGACTGGGTA SEQ ID NO :402 3 7 REV TATGCA^.GCTTAGGAGGCCACGGTGACTGG SEQ ID NO :403 25 33REV TATGCAAGCTTAGTTGGAGGCCACGGTGAC SZQ ID MO :404 3 9 REV TATGCAAGCTTACAGGTTGGAGGCCACGGT SEQ ID MO :405 30 41 REV TATGC^AGCTTAGTCCAGGTTGGAGGCCAC SEQ ID NO：406 4 2 REV 35 TATGCAAGCTTACTCGTCCAGGTTGGAGGC SSQ ID M〇：407 4 3 REV TATGC.-AGCTTAOTCCTCGTCCAGGTTGGA SEQ ID MO :408 40 39N TERM- -2 GACTAGCCATGGCNGAYGARGARCTGTGYGGTGGCCTCTGGCGG SEQ ID NO:409 SMA 31CTERM GACTAGTACGTACTGCAGGTTGGAGGCCACGG SEQ ID MO :410 45 29SM31 GCAGGTTACGTATTGAAGCAGGTAGTCAGACAGCTC SEQ ID MO：4 L1 50 34SNAB1 GCAGGTTACGTACACGGTGACTGGGT^TCTTGAAG SSQ ID MO :412 63SNAB1 GCAGGTTACGT^GTCTTGAGCCGCTCCATCCAGC SEQ ID NO： 413 55 66SMAB1 GCAGGTTACGTAGCCAGCGACAGTCTTGAGCCGCTC SEQ ID NO :4 14 -105 -

O:\92\92747.DOC 200413407 39N-TERMCSLI GTCAAGCCATGGCNCCRCCRAGCTGTCTRCGCT TCGTTCAGACCAACTC SEQ ID MO：415 5 39SMA31 GCAGGTTACGTACGGCTGAAAGGCACATTTGGTGACAA SEQ ID N MO :416 945 SHB1 GCAGGTTACGTAAAGACAGCTC-GGGGGGGG SEQ ID Ν〇·-417 10 93SUA31 GCAGGTTACGTACTGGACG^GCGA.\GACAGCTG SEQ ID MO :418 BAM FOR 1 TCAGTTGGATCCGGCGGCGG.^AGCGGAGGTGGCTCTGGGGGAGGTA SEQ ID MO：426 15 3AiM REV 1 TCAGTTGGATCCTCCGCCAG^CCACCGCCTGACCCACCTCCTGACCC SEQ ID NO:427 NAVREV L GTCTGAGGCGCCACCGCACCGACCGCTGGACAACCGCCTCTGACCC AGGACTGCTCCTTC SEQ ID MO：423 20 NAVREV S GTCTGAGGCGCCACCGCACCGACCACCCAGGACTGCTCCTTCC.\AC SEQ ID MO :42 9 NAVFOR 25 GTCTGAGGCGCCGAGTC-GACGCGGGCTCCACGGTGGCGGCAGGGT TGAGGAGTCGGGCTG SEQ ID NO:430 X3AF0R1 GCTACGTCTAGATCTCCTGACCTCGACCCAGGACTGCTCCTTCC^JXC SEQ ID N〇：447 30 XBAREVi GCTAGTTCTAGACCATCCTGGCTGACACGGTGAAACACCGTCTCTACG GGCTGACACTGCAGCTCCAG SEQ ID MO：448 LNK1FOR 35 GTCAGTACTAGTATGGGTGTCCGGGCTCTTCGGCTCCTGCAGG TTGGAGGCCACGG SEQ ID NO：449 LNK1REV GTCAGTACTAGTGCGCCATCTCCGACACCATTAC-GCCCTGCCAGC SEQ ID MO:450 40 LNK2FOR GTCAGTTCCGGAC'VTTTCGGTTCTGCAGAGGGCTGCGCAAGG TGGCGTA SEQ ID MO： 451 LNK2REV GTCAGTTCCGGATACTCATACCAGCCCGCCATCCCCGGGTTCTA ATCTGC^.GATGA*AGAGCTG SEQ ID MO :452 45 GTCAGTACTAGTATGGGTGTCCGGGCTCTTCGGA^AGGCACATTT GG丁GACAAAGTGTATC SEQ ID NO：453 LNK7RcV 50 GTCAGTACTAGTCCGCCATCTCCGGGTACACCATTAGGCCCTG CCAGC SEQ IC MO: 454 LNK3RE：V GTCAGTTCCGGATACTCATACCAGCCCGCCATCCCCGGGTA.\GGCC TTTCAGCCCCCCCCCAG SEQ ID M〇：455 55 ClFOR GTCAGACCATGGCCACTCAGGACTCCTCTTTTC S£Q ID MO：456

O:\92\92747.DOC -106- 200413407 C3F〇R CACTTTGTCACC.\AATCTGCCTTTCAG 3EQ ：D NO :457 C3REV * CTGAAAGGCAGATTTGGTGACAAAGTG SEQ ID NO :458 5 C5FOR GCCCCCCCCCAGCTCTCTTCG S£Q ID MO :459 C5REV CGAAGAGAGCTGGGGGGGGGC SEQ ID NO :460 C6REV 10 GTCAGTTACGTACAGGGTTG^GGAGTCGGGCTGAGACTGC SEQ MO：4 β 1 GPFOR1 GTCAGTCCATGGCTACTCAAGGTGCTATGC SEQ ID NO：462 GPREV2 !5 GTAGCATACGTAGGGCTGCAGGGCAGGGGCC S£Q ID NO：463 O:\92\92747.DOC -107- 200413407 表2 ϋ序列'(SEQ ID =序列编號） PMOM30304 5 GCT^CTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTGCACCTTTGCTGGACCCG.^AC AACCTCAATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCC^^CCTGGAGAGCTTCGT^GG GCTGTCAAGAACTTAGAAAATGCATCAGGTATTCAGGCAATTCTTCGTAATCTCCAACCATGTCTGCCCTCTGCC ACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAJ\AAACTGACGTTC 10 TATCTGGTTACCCTTGAGCA.^GCGCAGGAACAACAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCT GGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGT SEQ ID NO: i 15 pMON26453 20 25

TCCCCAGCTCCACCTGCTTGTGACCTCCGAGTCCTCAGTAAACTGCTTCGTGACTCCCATGTCCTTCACAGCAGA CTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTCCTGCTGCCTGCTGTGGACTTTAGCTTGGGAG^A TGGA.^^ACCCAGATGGAGGAGACCAAGGCACAGGACATTCTGGGAGCAGTGACCCTTCTGCTGGAGGGAGTGATG GCAGCACGGGGACAACTGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAGCTTTCTGGACAGGTCCGTCTCCTC CTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGCTTCCTCCACAGGGCAGGACCACAGCTCACAAGGATCCCAAT GCCATCTTCCTGAGCTTCCAACACCTGCTCCGAGGAAAGGTGCGTTTCCTGATGCTTGTAGGAGGGTCCACCCTC TGCGTCAGGGAATTC SEQ ID NO:2

PMCN2854S TCCCCAGCTCCACCTGCTTGTGACCTCCGAGTCCTCAGTAAACTGCTTCGTGACTCCCATGTCCTTCACAGCAGA CTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTCCTGCTGCCTGCTGTGGACTTTAGCTTGGGAGA；\ TGGAAAACCCAGATGGAGGAGACCAAGGCACAGGACATTCTGGGAGCAGTGACCCTTCTGCTGGAGGGAGTGATG 30 GCAGCACGGGGACAACTGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAGCTTTCTGGACAGGTCCGTCTCCTC CTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGCTTCCTCCACAGGGCAGGACCACAGCTCACAAGGATCCC.\.Vr GCCATCTTCCTGAGCTTCCAA.CACCTGCTCCGAGGAAAGGTGCGTTTCCTGATGCTTGTAGGAGGGTCCACCCTC TGCGTCAGGGAATTCGGCGGCAACATGGCGTCTCCCGCTCCGCCTGCTTGTGACCTCCGAGTCCTCAGTAAACTG CTTCGTGACTCCCATGTCCTTCACAGCAGACTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTCCTG 35 CTGCCTGCTGTGGACTTTAGCTTGGGAGAATGGAAA.\CCCAGATGGAGGAGACCAAGGCACAGGACATTCTGGGA GCAGTGACCCTTCTGCTGGAGGGAGTGATGGCAGCACGGGGACAACTGGGACCCACTTGCCTCTCATCCCTCCTG GGGCAGCTTTCTGGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGA^.CCCAGGGCAGGACCACA GCTCACAAGGATCCCA.^TGCCATCTTCCTGAGCTTCCAACACCTGCTCCGAGGAA.^GGTGCGTTTCCTGATGCTT GTAGGAGGGTCCACCCTCTGCGTCAGG SEQ ID MO : 3 40

pMON2350Q 45 50 55 TCCCiCAGCTCCACCTGCTTGTGACCTCCGAGTCCTCAGTAAACTGCTTCGTGACTCCCATGTCCTTCACAGCAGA ； CTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTCCTGCTGCCTGCTGTGGACTTTAGCTTGGGAGAA . TGGAAAACCCAGATGGAGGAGACC.^AGGCACAGGACATTCTGGGAGCAGTGACCCTTCTGCTGGAGGGAGTGATG ； GCAGCACGGGGACA^.CTGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAGCTTTCTGGACAGGTCCGTCTCCTC ' CTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGCTTCCTCCACAGGGCAGGACCACAGCT.CACAAGGATCCC^T ; GCCATCTTCCTGAGCTTCCAACACCTGCTCCGAGGAAAGGTGCGTTTCCTGATGCTTGTAGGAGGGTCCACCCTC ； TGCGTCAGGGAATTCGGCAACATGGCGTCTCCCGCTCCGCCTGCTTGTGACCTCCGAGTCCTCAGTAAACTGCTT ! CGTGACTCCCATGTCCTTCACAGCAGACTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTCCTGCTG ； CCTGCTGTGGACTTTAGCTTGGGAGAATGGAAAACCCAGATGGAGGAGACC^-AGGCACAGGACATTCTGGGAGCP^ i GTGACCCTTCTGCTGGAGGGAGTGATGGCAGCACGGGGAC.-J\CTGGGACCCACTTGCCTCTCATCCCTCCTGGGG ; CAGCTTTCTGGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGCTTCCTCCACAGGGC ’丨 AGGACCACAGCTCACAAGGATCCCAATGCCATCTTCCTGAGCTTCCAACACCTGCTCCGAGGAAAGGTGCGTTTT:： CTGATGCTTGTAGGAGGGTCCACCCTCTGCGTCAGG SEQ ID NO : 4 !

PMOM235C1 TCCCCAGCTCCACCTGCTTGTGACCTCCGAGTCCTCAGT.^^ACTGCTTCGTGACTCCCATGTCCTTCACAGCAGA. 60 CTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTCCTGCTGC(：TGCTGTGGACTTTAGCTTGGGAGAA TGGAAAACCCAGATGGAGGAGACCAAGGCACAGGACATTCTGGGAGCAGTGACCCTTCTGCTGGAGGGAGTGATG GCAGCACGGGGAC^CTGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAGCTTTCTGGACAGGTCCGTCTCCTC CTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGCTTCCTCCACAGGGCAGGACCACAGCTCACAAGGATCCCr'-AT GCCATCTTCCTGAGCTTCCA^.CACCTGCTCCGAGGAAAGGTGCGTTTCCTGATGCTTGTAGGAGGGTCCACCCTC 65 'TGCGTCAGGGAATTCGGCGGCAACATGGCGTCTCCCGCTCCGCCTGCTTGTGACCTCCGAGTCCTCAGTAAACTG CTTCGTGACTCCCATGTCCTTCACAGCAGACTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTCCTG CTGCCTGCTGTGGACTTTAGCTTCGGAGAATGGAAAACCCAGATGGAGGAGACC^GGCACAGGACATTCTGGGA GCAGTGACCCTTCTGCTGGAGGGAGTGATGGCAGCACGGGGAC.\ACTGGGACCCACTTGCCTCTCATCCCTCCTG GGGCAGCTTTCTGGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGCTTCCTCCACPvG 70 OGCAGGACCACAGCTCAC^.GGATCCCP^ATGCCATCTTCCTGAGCTTCC.VvCACCTGCTCCGAGGAAAGGTGCGT TTCCTGATGCTTGTAGGAGGGTCCACCCTCTGCGTCAGG SEQ ID NO: 5 PMOM23502 108-

O:\92\92747.DOC 200413407 TCCCCAGCGCCGCCTGCTTGTGACCTCCGAGTCCTCAGTA^^CTGCTTCGTGACTCCCATGTCCTTCACAGCAGA CTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTCCTGCTGCCTGCTGTGGACTTTAGCTTGGGAGAA TGGA^^*ACCCAGATGGAGGAGACC^GGCACAGGACATTCTGGGAGCAGTGACCCTTCTGCTGGAGGGAGTGATG GCAGCACGGGGACAACTGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAGCTTTCTGGACAGGTCCGTCTCCTC 5 CTTGGGGCCCTGCAGAGCCTCCTTGG^CCCAGCTTCCTCCACAGGGCAGGACCACAGCTCACAAGGATCCC^T GCCATCTTCCTGAGCTTCCAACACCTGCTCCGAGGAAAGGTGCGTTTCCTGATGCTTGTAGGAGGGTCCACCCTC TGCGTCAGGGAAlTCGGCGGCAACGGCGGCAACrVTGGCGTCCCCAGCGCCGCCTGCTTGTGACCTCCGAGTCCTC AGTAAACTGCTTCGTGACTCCCATGTCCTTCACAGCAGACTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACA CCTGTCCTGCTGCCTGCTGTGGACTTTAGCTTGGGAGAATGG.^AAACCCAGATGGAGGAGACC.\AGGCACAGGAC 10 ATTCTGGGAGCAGTGACCCTTCTGCTGGAGGGAGTGATGGCAGCACGGGGACA.^CTGGGACCCACTTGCCTCTCA TCCCTCCTGGGGCAGCTTTCTGGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGCTT CCTCCACAGGGCAGGACCACAGCTCAC^.GGATCCCA.\TGCCATCTTCCTGAGCTTCC.\ACACCTGCTCCGAGGA .^AGGTGCGTTTCCTGATGCTTGTAGGAGGGTCCACCCTCTGCGTCAGG S£〇 ID MO . δ 15 .

Syntanl 20 25 30

I CATGGCT^C TGCTCTATAA TGATCGATGA AATTATACAT CACTT^\AGA 51 GACCACCTGC ACCTTTGCTG GACCCGAACA ACCTCAATGA CGAAGACGTC 101 TCTATCCTGA TGGACCGAi^A CCTTCGACTT CCAAACCTGG AGAGCTTCGT 151 A.-\GGGCTGTC AAGAACTTAG *\AAATGCATC AGGTATTGAG GC^ATTCTTC 201 GTAATCTCCA ACCATGTCTG CCCTCTGCCA CGGCCGCACC CTCTCGACAT 251 CCAATmA TCAAGGCAGG TGACTGGCAA GAATTCCGGG AAAAACTGAC 301 GTTCTATCTG GTTACCCTTG AGCAAGCGCA GGAAC.^CAG GGTGGTGGCT 251 CTAACTGCTC TATAATGATC GATGAAATTA TACATCACTT AAAGAGACCA 401 C.CTGCACCTT TGCTGGACCC G.\ACAACCTC A.^TGACGAAG PvCGTCTCTAT 451 CCTGATGGAC CGAAACCTTC GACTTCCAAA CCTGGAGAGC TTCGTAAGGG 5Q1 CTGTCAAGAA CTTAGAAAAT GCATCAGGTA TTGAGGC^J\T TCTTCGTAAT 551 CTCCAACCAT GTCTGCCCTC TGCCACGGCC GCACCCTCTC GACATCCAAT 601 CATCATCAAG GCAGGTGACT GGCAAGAATT CCGGGAAAAA CTGACGTTCT 651 ATCTGGTTAC CCTTGAGCAA GCGCAGGAAC AACAGTAC SEQ I3U

35 S'/ntan3 40 45 50 1 CATGGCT.\i.C TGCTCTATAA TGATCGATGA AATTATACAT CACTTX\AGA 5： GACCACCTGC ACCTTTGCTG GACCCGAACA ACCTCAATGA CG^GACGTC 101 TCTATCCTGA TGGACCGAAA CCTTCGACTT CCAAACCTGG AGAGCTTCGT 1S1 AAGGGCTGTC AAGAACTTAG AAAATGCATC AGGTATTGAG GCAATTCTTC 201 GT^TCTCCA ACCATGTCTG CCCTCTGCCA CGGCCGCACC CTCTCGACAT 251 CCAATCATCA TCAAGGCAGG TGACTGGC.^A GAATTCCGGG AA^AACTGAC 301 GTTCTATCTG GTTACCCTTG AGCAAGCGCA OGAACAACAG GGTGGTGGCT 351. CTGGCGGTGG CAGCGGCGGC GGTTCTAACT GCTCTATAAT GATCGATGAA 401 ATTATACATC ACTTAAAGAG ACCACCTGCA CCTTTGCTGG ACCCGAACAA 451 CCTCAATGAC GA^GACGTCT CTATCCTGAT GGACCGAAAC CTTCGACTTC 501 C^Ar^CCTGGA GAGCTTCGTA AGGGCTGTCA AGAACTTAGA A.\ATGCATCA 551 GGTATTGAGG CAATTCTTCG'TAATCTCCAA CCATGTCTGC CCTCTGCCAC 601 GGCCGCACCC TCTCGACATC CAATCPvTCJVT CAAGGCAGGT GACTGGCAAG 651 AATTCCGGGA P^AACTGACG TTCTATCTGG TTACCCTTGA GC；^GCGCAG 701 GAACAACAGT AC SEQ ID NG:3

55 DMOM311Q4 60 65 70 75

51 101 151 201 251 301 351 401 451 501 551 601 65.1 701 751 301 351 90 L

ATGGCTCTGG ACCCGAAC^ CCTCAATGAC GAAGACGTCT CTATCCTGAT GGACCGA^C CTTCGACTTC CAAACCTGGA GAGCTTCGTA AGGGCTGTCA AGAACTTAGA ^^TGCATCA GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC TCTCGACATC C.\ATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGG GTGGTGGCTC TAACTGCTCT AT.^ATGATCG ATGA^TTAT ACATCACTTA AAGAGACCAC CTGvCACCTTT GTACGTAGAG GGCGGTGGAG GCTCCCCGGG TGAACCGTCT GGTCC.^TCT CTACTATC^ CCCGTCTCCT CCGTCT.\A^.G AATCTCATAA ATCTCCAAAC ATGGCTACCC AGGGTGCCAT GCCGGCCTTC GCCTCTGCTT TCCAGCGCCG GGCAGGAGGG GTCCTGGTTG CTAGCCATCT GCAGAGCTTC CTGGAGGTGT CGTACCGCGT TCTACGCCAC CTTGCGCAGC CCTCTGGCGG CTCTGGCGGC

TCTCAGAGCT TCCTGCTC.^ OTCTTTAGAG CMGTGAGAA AGATCCAGGG Λ nn ^ λ ^rry Λ rr^ rry ^ ! L L; ACCCCGAGGA GCTGGTGCTG CTCGGACACT •.rCCCTGAGCT CCTGCCCCAG CCAGGCCCTG ，.:CAACTCC.VT AGCGGCCTTT TCCTCTACCA -•^GGGATATC CCCCGAGTTG GGTCCCACCT OTCGCCGACT TTGCCACCAC CATCTGGCAG *i r\^i

TGCCACCTAC CTCTGGGCAT CAGCTGGCAG GGGGCTCCTG TGGACACACT CAGATGGAAG

CCCCTGGGCT GCTGCTTGAG CAGGCCCTGG GCAGCTGGAC AACTGGGAAT

O:\92\92747.DOC -109- 200413407 951 GGCCCCTGCC CTGCAGCCCT ΛΑΤΑΑ SEQ ID MO:9 10 15 20 25 PMON3U0 5 1 ATGGCTAATG CATCAGGTAT TGAGGC^TT CTTCGTAATC TCCAACCATG 51 TCTGCCCTCT GCCACGGCCG CACCCTCTCG ACATCC^TC ATCATCAAGG 101 CAGGTGACTG GCAAGAATTC CGGGA.\AA.aC TGACGTTCTA TCTGGTTACC 151 CTTGAGCAAG CGCAGGAACA ACAGGGTGGT GGCTCTAACT GCTCTATAAT 201 GATCGATGAA ATTATACATC ACTT.\-\AGAG ACCACCTGCA CCTTTGCTGG 251 ACCCG.\ACAA CCTCAATGAC G.^GACGTCT CTATCCTGAT GGACCGAAAC 301 CTTCGACTTC CAAACCTGGA GAGCTTCGTA AGGGCTGTCA AG^CTTAGA 351 ATACGTAGAG GGCGGTGGAG GCTCCCCGGG TGAACCGTCT GGTCC^TCT 401 CTACIATCAA CCCGTCTCCT CCGTCTAAAG AATCTCATAA ATCTCCAAAC 451 ATGGCTACCC AGGGTGCCAT GCCGGCCTTC GCCTCTGCTT TCCAGCGCCG 501 GGCAGGAGGG GTCCTGGTTG CTAGCCATCT GCAGAGCTTC CTGGAGGTGT 551 CGTACCGCGT TCTACGCCAC CTTGCGCAGC CCTCTGGCGG CTCTGGCGGC 601 TCTCAGAGCT TCCTGCTC.\A GTCTTTAGAG C.^GTGAGAA AGATCCAGGG 651 CGATGGCGCA GCGCTCCAGG AGAAGCTGTG TGCCACCTAC AAGCTGTGCC 701 ACCCCGAGGA GCTGGTGCTG CTCGGACACT CTCTGGGCAT CCCCTGGGCT 751 CCCCTGAGCT CCTGCCCCAG CCAGGCCCTG CAGCTGGCAG GCTGCTTGAG 801 CCAACTCCAT AGCGGCCTTT TCCTCTACCA GGGGCTCCTG CAGGCCCTGG 851 .\AGGGATATC CCCCGAGTTG GGTCCCACCT TGGACACACT GCAGCTGGAC 901 GTCGCCGACT TTGCCACCAC CATCTGGCAG CAGATGGAAG AACTGGGAAT 951 GGCCCCTGCC CTGCAGCCCT AATAA SEQ ID NO :10

pM〇N31106 30 i 51 101 151 201 35 251 301 351 401 451 40 501 551 〇01 651 701 45 751 801' 351 901 951 50

ATGGCTGCAC

AGAATTCCGG

AGGAACAACA

ATACATCACT

CAATGACGAA

ACCTGGAGAG

ATTGAGGCAA

CTACGTAGAG

CTACTATCAA

ATGGCTACCC

GGCAGGAGGG

CGTACCGCGT

TCTCAGAGCT

CGATGGCGCA

ACCCCGAGGA

CCCCTGAGCT

CCAACTCCAT

AAGGGATATC

GTCGCCGACT

GGCCCCTGCC

CCTCTCGACA

GAAAAACTGA

GGGTGGTGGC

TAAAGAGACC

GACGTCTCTA

CTTCGTAAGG

TTCTTCGTAA

GGCGGTGGAG

CCCGTCTCCT

AGGGTGCCAT

GTCCTGGTTG

TCTACGCCAC

TCCTGCTCAA

GCGCTCCAGG

GCTGGTGCTG

CCTGCCCCAG

AGCGGCCTTT

CCCCGAGTTG

TTGCCACCAC CTGCAGCCCT.

TCCAATCATC CGTTCTATCT TCTAACTGCT ACCTGCACCT TCCTGATGGA GCTGTCAAGA TCTCCAACCA GCTCCCCGGG CCGTCTAAAG GCCGGCCTTC CTAGCCATCT CTTGCGCAGC GTCTTTAGAG AGAAGCTGTG CTCGGACACT CCAGGCCCTG TCCTCTACCA GGTCCCACCT CATCTGGCAG AATAA SEQ ATCAAGGCAG GGTTACCCTT CTATAATGAT TTGCTGGACC CCGAAACCTT ACTTAGAAAA TGTCTGCCCT TGAACCGTCT AATCTCATAA GCCTCTGCTT GCAGAGCTTC CCTCTGGCGG CAAGTGAGAA TGCCACCTAC CTCTGGGCAT CAGCTGGCAG GGGGCTCCTG TGGACACACT CAGATGGAAG ：D MO:11

GTGACTGGCA

GAGCAAGCGC

CGATGAAATT

CGAACAACCT

CGACTTCCAA

TGCATCAGGT

CTGCCACGGC

GGTCCAATCT

ATCTCCAAAC

TCCAGCGCCG

CTGGAGGTGT

CTCTGGCGGC

AGATCCAGGG

AAGCTGTGCC

CCCCTGGGCT

GCTGCTTGAG

CAGGCCCTGG

GCAGCTGGAC

AACTGGGAAT

PMCN31107

L ATGGCTGCAC 55 5 L GGTTACCCTT 101' CTATAATGAT 151 TTGCTGGACC 201 CCGAAACCTT 251 ACTTAGAAAA 60 301 TGTCTGCCCT 351 GTACSTAGAG 401 CTACTATCAA 451 ATGGCTACCC SOL 65 SSL CGTACCGCGT 601 TCTCAGAGCT 651 CGATGGCGCA 701 '·广广 ^ 广、 751 CCCCTGAGCT 70 801 CCAACTCCAT 35 L AAGGGATATC 90 L OTCGCCGACT 951 GGCCCCTGCC

GAGCAAGCGC AGGAACAACA CGATGAAATT ATACATCACT CGAACAACCT CAATGACGAA CGACTTCCAA ACCTGGAGAG rp 广 p 'rp 广广 rn 、rprp^* '广 p 广' λ

CTGCCACGGC CGCACCCTCT GGCGGTGGAG GCTCCCCGGG CCCGTCTCCT CCGTCTAAAG AGGGTGCCAT GCCGGCCTTC GTCCTGGTTG CTAGCCATCT TCTACGCCAC CTTGCGCAGC TCCTGCTCA.^ GTCTTTAGAG GCGCTCCAGG AGAAGCTGTG GCTGGTGCTG CTCGGACACT CCTGCCCCAG CCAGGCCCTG AGCGGCCTTT TCCTCTACCA CCCCGAGTTG GGTCCCACCT TTGCCACCAC CATCTGGCAG CTGCAGCCCT AATAA SEQ

GAAAAACTGA CGTTCTATCT GGGTGGTGGC TCTAACTGCT TAAAGAGACC ACCTGCACCT GACGTCTCTA TCCTGATGGA CTTCGTAAGG GCTGTCAAGA TTCTTCGTAA TCTCCAACCA CGACATCCAA TCATCATCAA TGAACCGTCT GGTCCAATCT AATCTCATAA ATCTCCAAAC GCCTCTGCTT TCCAGCGCCG GCAGAGCTTC CTGGAGGTGT CCTCTGGCGG CTCTGGCGGC CAAGTGAGAA AGATCCAGGG TGCCACCTAC AAGCTGTGCC CTCTGGGCAT CCCCTGGGCT CAGCTGGCAG GCTGCTTGAG GGGGCTCCTG CAGGCCCTGG TGGACACACT GCAGCTGGAC CAGATGGAAG AACTGGGAAT ID MO : 12 75

O:\92\92747.DOC -110- 200413407 PMON31103 5 o 5 20 1 ---f l· r—4 1 ril丄 1 1 1 1 Γ1i r--ri 1 1 1 1---ΓΗ 5 05050 5 050 5 05050505 1 r-i C.J c'】3 3 4 4 s 5 v°6 7 7 00 8 9 9

ATGGCTCTGG GGACCGAAAC AGAACTTAGA CCATGTCTGC CAAGGCAGGT TTACCCTTGA AGCGGCGGCG CTTAAVGAGA CGGGTGAACC AAAGAATCTC CTTCGCCTCT ATCTGCAGAG CAGCCCTCTG AGAGCAAGTG TGTGTGCCAC CACTCTCTGG CCTGCAGCTG ACCAGGGGCT ACCTTGGACA GCAGCAGATG SEQ ID NC ACCCGAACAA CTTCGACTTC AAATGCATCA CCTCTGCCAC GACTGGCAAG GCAAGCGCAG GTTCTAACTG CCACCTGCAC GTCTGGTCCA ATAAATCTCC GCTTTCCAGC CTTCCTGGAG GCGGCTCTGG AGAAAGATCC CTACAAGCTG GCATCCCCTG GCAGGCTGCT CCTGCAGGCC CACTGCAGCT GAAGAACTGG :13

CCTCAATGAC CAAACCTGGA GGTATTGAGG GGCCGCACCC A/VTTCCGGGA GAACAACAGG CTCTATAATG CTTTGTACGT ATCTCTACTA AAACATGGCT GCCGGGCAGG GTGTCGTACC CSGCTCTCAG AGGGCGATGG TGCCACCCCG GGCTCCCCTG TGAGCCAACT CTGGAAGGGA GGACGTCGCC GAATGGCCCC

GAAGACGTCT GAGCTTCGTA C.^TTCTTCG TCTCGACATC AAAACTGACG GTGGTGGCTC ATCGATGAAA AGAGGGCGGT TCAACCCGTC ACCCAGGGTG AGGGGTCCTG GCGTTCTACG AGCTTCCTGC CGCAGCGCTC AGGAGCTGGT AGCTCCTGCC CCATAGCGGC TATCCCCCGA GACTTTGCCA TGCCCTGCAG

CTATCCTGAT AGGGCTGTCA TAATCTCCAA CAATCATCAT TTCTATCTGG TGGCGGTGGC TTATACATCA GGAGGCTCCC TCCTCCGTCT CCATGCCGGC GTTGCTAGCC CCACCTTGCG TCAAGTCTTT CAGGAGAAGC GCTGCTCGGA CCAGCCAGGC CTTTTCCTCT GTTGGGTCCC CCACCATCTG CCCTAiVTAA 25 pMON31109

1 ATGGCTAATG CATCAGGTAT TGAGGCAATT CTTCGTAATC TCCAACCATG' 51 TCTGCCCTCT GCCACGGCCG CACCCTCTCG ACATCCAATC ATCATCAAGG 101 CAGGTGACTG GCAAGAATTC CGGGAAAAAC TGACGTTCTA TCTGGTTACC 30 151 CTTGAGCAAG CGCAGGAACA ACAGGGTGOT GGCTCTGGCG GTGGCAGCGG

201 CGGCGGTTCT AACTGCTCTA T.^ATGATCGA TGAAATTATA CATCACTTAA 251 AGAGACCACC TGCACCTTTG CTGGACCCGA ACAACCTCAA TGACGAAGAC 301 GTCTCTATCC TGATGGACCG AAACCTTCGA CTTCCAAACC TGGAGAGCTT ^ 351 CGTAP>.GGGCT GTCAAGAACT TAGAATACGT AGAGGGCGGT GGAGGCTCCC

35 401 CGGGTGAACC GTCTGGTCCA ATCTCTACTA TCAACCCGTC TCCTCCGTCT

451 AAAGAATCTC ATAAATCTCC AAACATGGCT ACCCAGGGTG CCATGCCGGC 501 CTTCGCCTCT GCTTTCCAGC GCCGGGCAGG AGGGGTCCTG GTTGCTAGCC 551 ATCTGCAGAG CTTCCTGGAG GTGTCGTACC GCGTTCTACG CCACCTTGCG 601 CAGCCCTCTG GCGGCTCTGG CGGCTCTCAG AGCTTCCTGC TCAAGTCTTT 40 651 AGAGCAAGTG AGAAAGATCC AGGGCGATGG CGvCAGCGCTC CAGGAGAAGC

701 TGTGTGCCAC CTACAAGCTG TGCCACCCCG AGGAGCTGGT GCTGCTCGGA 751 CACTCTCTGG GCATCCCCTG GGCTCCCCTG AGCTCCTGCC CCAGCCAGGC 801 CCTGCAGCTG GCAGGCTGCT TGAGCC^J\CT CCATAGCGGC CTTTTCCTCT 351 ACCAGGGGCT CCTGCAGGCC CTGGAAGGGA TATCCCCCGA GTTGGGTCCC 45 901· ACCTTGGACA CACTGCAGCT GGACGTCGCC GACTTTGCCA CCACCATCTG 95i GCAGCAGATG GAAGAACTGG GAATGGCCCC TGCCCTGCAG CCCTAATAA SEQ ID NO:14 50 PMOM3I1I0 60 65 70 51101 151201 251 301 351 401 45L 501 551 601 651 701 751 SOI 351 901 951

ATGGCTGCAC CCTCTCGACA AGAATTCCGG GAAAAACTGA AGGAACAACA GGGTGGTGGC TGCTCTATAJ\ TGATCGATGA ACCTTTGCTG GACCCG^CA 丁GGACCGAAA CCTTCGACIT AAGA^.CTTAG AAAATGCATC

ACCATGTCTG CGGGTGAACC P^AGAATCTC CTTCGCCTCT

CCCTCTGCCA GTCTGGTCCA ATAAATCTCC GCTTTCCAGC ATCTGCAGAG CTTCCTGGAG CAGCCCTCTG GCGGCTCTGG AGAGCAAGTG AGAAAGATCC TGTGTGCCAC CTACAAGCTG CACTCTCTGG GCATCCCCTG CCTGCAGCTG GCAGGCTGCT ACCAGGGGCT CCTGCAGGCC ACCTTGGACA CACTGCAGCT GCAGCA.GATG GAAGAACTGG SEQ ID NO：15

TCCAATCATC CGTTCTATCT m 广 m广广 jl L· x. o •tlA i 丄m i ^ i Vw λλ 1 CCAAACCTGG AGGTATTGAG CGGCCTACGT ATCTCTACTA AAACATGGCT GTGTCGTACC CGGCTCTCAG AGGGCGATGG TGCCACCCCG GGCTCCCCTG TGAGCCAACT CTGGAAGGGAGGACGTCGCC GAATGGCCCC ATCAAGGCAG GGTTACCCTT GCAGCGGCGG CACTTA^^GA CGAAGACGTC AGAGCTTCGT C-CAATTCTTC AGAGGGCGGT TCA.ACCCGTC ACCCAGGGTG AGGGGTCCTG GCGTTCTACG AGCTTCCTGC CGCAGCGCTC AGGAGCTGGT AGCTCCTGCC CCATAGCGGC TATCCCCCGAGnCTTTGCCA i. '-sj V., Vw A.

GTGACTGGCA GAGCAAGCGC CGGTTCTAAC GACCACCTGC TCTATCCTGA AAGGGCTGTC GTAATCTCCA GGAGGCTCCC TCCTCCGTCT CCATGCCGGC GTTGCTAGCC CCACCTTGCG TCAAGTCTTT CAGGAGAAGC GCTGCTCGGA CCAGCCAGGC CTTTTCCTCT GTTGGGTCCCCCACCATCTG CCCTAATAA OHOU21 75

O:\92\92747.DOC

ATGGCTGCAG GTGACTGGCA AGAATTCCGG GAA.^\CTGA CGTTCTATCT -Ill - 200413407 5 10 15 20 5 L GGTTACCCTT GA.GCAAGCGC AGGAAC.\ACA GGGTGGTGGC TCTGGCGGTG 101 GCAGCGGCGG CGGTTCTAAC TGCTCT.VTAA TGATCGATGA .\ATTATACAT 151 CACTTAAAGA GACCACCTGC ACCTTTGCTG GACCCGAACA ACCTCAATGA 201 C：GAAGACGTC TCTATCCTGA TGGACCGAAA CCTTCGACTT CCAAACCTGG 251 AGAGCTTCGT AAGGGCTGTC AAGAACTTAG AAAATGCATC AGGTATTGAG 3〇i GCAATTCTTC GT^TCTCCA ACCATGTCTG CCCTCTGCCA CGGCCGCACC 351 CTCTCGACAT CCAATCATCA TCAAGTACGT AGAGGGCGGT GGAGGCTCCC 401 CGGGTGAACC GTCTGGTCCA ATCTCTACTA TCAACCCGTC TCCTCCGTCT 451 AAAGAATCTC ATAAATCTCC AAACATGGCT ACCCAGGGTG CCATGCCGGC 501 CTTCGCCTCT GCTTTCCAGC GCCGGGCAGG AGGGGTCCTG GTTGCTAGCC 551 ATCTGCAGAG CTTCCTGGAG GTGTCGTACC GCGTTCTACG CCACCTTGCG 601 CAGCCCTCTG GCGGCTCTGG CGGCTCTCAG AGCTTCCTGC TCAAGTCTTT 〇5I AGAGCAAGTG AGAAAGATCC AGGGCGATGG CGCAGCGCTC CAGGAGAAGC 701 TGTGTGCCAC CTACAAGCTG TGCCACCCCG AGGAGCTGGT GCTGCTCGGA 751 CACTCTCTGG GCATCCCCTG GGCTCCCCTG AGCTCCTGCC CCAGCCAGGC SOI CCTGCAGCTG GCAGGCTGCT TGAGCCAACT CCATAGCGGC CTTTTCCTCT 851 ACCAGGGGCT CCTGCAGGCC CTGGAAGGGA TATCCCCCGA GTTGGGTCCC 901 ACCTTGGACA CACTGCAGCT GGACGTCGCC GACTTTGCCA CCACCATCTG 951 GCAGCAGATG GAAGAACTGG GAATGGCCCC TGCCCTGCAG CCCTAATAA SEQ ID MO : 16 ΌΜΟΝ13182 25 30 35 40 1 ATGGCTAACT GCTCT.VTAAT GATCGATGAA ATTATACATC ACTTAAAGAG 51 ACCACCTGCA CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT IQ1 CTATCCTGAT GGACCGAAAC CTTCGACTTC C.^AACCTGGA GAGCTTCGTA 151 AGGGCTGTCA AG*\ACTTAGA AAATGCATCA GGTATTGAGG CAATTCTTCG 201 T.\ATCTCC.\A CCATGTCTGC CCTCTGCCAC GGCCGCACCC TCTCGACATC 251 CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG 301 TTCTATCTGG TTACCCTTGA GCA.^GCGCAG GAACAACAGT ACGTAGAGGG 351 CGGTGGAGGC TCCCCGGGTG GTGGTTCTGG CGGCGGCTCC AACATGGCTT 401 ACAAGCTGTG CCACCCCGAG GAGCTGGTGC TGCTCGGACA CTCTCTGGGC 451 ATCCCCTGGG CTCCCCTGAG CTCCTGCCCC AGCCAGGCCC TGCAGCTGGC 501 AGGCTGCTTG AGCCAACTCC ATAGCGGCCT TTTCCTCTAC CAGGGGCTCC 551 TGCAGGCCCT GGAAGGGATA TCCCCCGAGT TGGGTCCCAC CTTGGACACA 601 CTGCAGCTGG ACGTCGCCGA CTTTGCCACC ACCATCTGGC AGCAGATGGA 551 AGA^.CTGGGA ATGGCCCCTG CCCTGCAGCC CACCCAGGGT GCCATGCCGG 701 CCTTCGCCTC TGCT^TTCCAG CGCCGGGCAG GAGGGGTCCT GGTTGCTAGC 751 CATCTGCAGA GCTTCCTGGA GGTGTCGTAC CGCGTTCTAC GCCACCTTGC 301 GCAGCCCTCT GGCGGCTCTG GCGGCTCTCA GAGCTTCCTG CTC^GTCTT 851 TAGAGCAAGT GAGAAAGATC CAGGGCGATG GCGCAGvCGCT CCAGGAGAAG 901 CTGTGTGCCA CCTAATAA SEQ ID NO :17

45 pMON.1313 3 50 60 65 1 ATGGCTAACT GCTCTATAAT GATCGATGAA A’TTiVTACATC ACTT.WAGAG 5 i ACCACCTGCA CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT 101 v：TATCCTGAT GGACCGAAAG CTTCGACTTC CAAACCTGGA GAGCTTCGTA 151 AGGGCTGTCA AG^CTTAGA .^ATGCATCA GGTATTGAGG CAATTCTTCG 201 TAATCTCC^ CCATGTCTGC CCTCTGCCAC GGCCGCACCC TCTCGACATC 2 5 3. CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTC-ACG 301 TTCT.-.TCTGG TTACCvCTTGA GC.^GCGCAG GAJ\CA.\CAGT ACGTAGAGGG 351 CGGTGGAGGC TCCCCGGGTG .^CCGTCTGG TCC,\ATCTCT •二.CTATCAACC 401 CGTCTCCTCC GTCTAAAGAA TCTCATAAAT CTCCAAACAT GGCTTACAAG 451 CTGTGCCACC CCGAGGAGCT GGTGCTGCTC GGACACTCTC TGGGCATCCC 501 CTGGGCTCCC CTGAGCTCCT GCCCCAGCCA GGCCCTGCAG CTGGCAGGCT 551 GCTTGAGCCA ACTCCAT.-vGC GGCCTTTTCC TCTACCAGGG GCTCCTGCAG 601 GCCCTGGA^G GGATATCCCC CGAGTTGGGT CCCACCTTGG ACACACTGCA 651 GCTGGACGTC GCCGACTTTG CCACCACCAT CTGGCAGCAG ATGGAAG.^C 701 TGGGAATGGC CCCTGCCCTG CAGCCCACCC AGGGTGCCAT GCCGGCCTTC 751 GCCTCTGCTT TCCAGCGCCG GGCAC-GAGGG GTCCTGGTTG CTAGCCATCT 301 GCAGAGCTTC CTGGAGGTGT CGTACC3CGT TCTACGCCAC CTTGCGCAGC 851 CCTCTGGCGG CTCTGGCGGC TCTCAGAGCT TCCTGCTCA.-^ GTCTTTAGAG 901 CAAGTGAGAA AGATCCAGGG CGATGGCGCA C3CGCTCCAGG AGAAGCTGTG 951 TGCCACCT.Vv T.^ SEQ ID MO : 13

OMCM131R4 i ATGGCT.V\CT GCTCTAT.^T GATCGATG^-X ATTATACATC ACTT；^GAG 51 ACCACCTGCA CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT 101 CTATCCTGAT GGACCGAAAG CTTCGACTTC CAAACCTGGA GAGCTTCGTA LSI AGGGCTGTCA AG.\.\CTTAGA .AAATGCATCA GGTATTGAGG C.^ATTCTTCGZQl T^TCTCCM CCATGTCTjC CCTCTGCCAC GGCCGCACCC TCTCGACATC

O:\92\92747.DOC -112- 200413407 10 251 301 351 401 451 501 551 601 651 701 751 801 351 901 15

CAATCATCAT TTCTATCTGG CGGTGGAGGC CCGAGTTGGG GCCACCACCA GCAGCCCACC GGGCAGGAGG TCGTACCGCG CTCTCAGAGC GCGATGGCGC CACCCCGAGG TCCCCTGAGC GCCAACTCCA GAAGGGATAT CAAGGCAGGT GACTGGCAAG TTACCCTTGA GCAAGCGCAG TCCCCGGGTG GTGGTTCTGG TCCCACCTTG GACACACTGC TCTGGCAGCA GATGGAAGAA CAGGGTGCCA TGCCGGCCTT GGTCCTGGTT GCTAGCCATC TTCTACGCCA CCTTGCGCAG TTCCTGCTCA AGTCTTTAGA AGCGCTCCAG GAGAAGCTGT AGCTGGTGCT GCTCGGACAC TCCTGCCCCA GCCAGGCCCT TAGCGGCCTT TTCCTCTACC CC丁AATAA SEQ ID N〇：丄9

AATTCCGGGA GAACAACAGT CGGCGGCTCC AGCTGGACGT CTGGGAATGG CGCCTCTGCT TGCAGAGCTT CCCTCTGGCG GCAAGTGAGA GTGCCACCTA TCTCTGGGCA GCAGCTGGCA AGGGGCTCCT

AAAACTGACG ACGTAGAGGG AACATGGCTC CGCCGACTTT CCCCTGCCCT TTCCAGCGCC CCTGGAGGTG GCTCTGGCGG AAGATCCAGG CAAGCTGTGC TCCCCTGGGC GGCTGCTTGA GCAGGCCCTG OMON13I35 20 5 2 i 4 4 L〇 5 6 6 { 5 rj 8 8 9 9 1 11 1X f «—I -—i -—*ί T—ί 1—I t--f 1-i 1-1Ί i .--^ II 5Q 5 05050 5 050 5 05050 5 ATGGCTAACT ACCACCTGCA CTATCCTGAT AGGGCTGTCA TAATCTCCAA CAATCATCAT TTCTATCTGG CGTCTCCTCC TTGGGTCCCA CACCATCTGG CCACCCAGGG GGAGGGGTCC CCGCGTTCTA AGAGCTTCCT GGCGCAGCGC CGAGGAGCTG TGAGCTCCTG CTCCATAGCG GATATCCT^

GCTCTATAAT CCTTTGCTGG GGACCGAAAC AGAACTTAGA CCATGTCTGC CAAGGCAGGT TTACCCTTGA TCCCCGGGTG GTCTAAAGAA CCTTGGACAC CAGCAGATGG TGCCATGCCG TGGTTGCTAG CGCCACCTTG GCTCAAGTCT TCCAGGAGAA GTGCTGCTCG CCCCAGCCAG GCCTTTTCCT TAA SEQ ID GATCGATGAA ACCCGAACAA CTTCGACTTC AAATGCATCA CCTCTGCCAC GACTGGCAAG GCAAGCGCAG AACCGTCTGG TCTCATAAAT ACTGCAGCTG AAGAACTGGG GCCTTCGCCT CCATCTGCAG CGCAGCCCTC TTAGAGCAAG GCTGTGTGCC GACACTCTCT GCCCTGCAGC CTACCAGGGG MO :20

ATTATACATC CCTCAATGAC CAAACCTGGA GGTATTGAGG GGCCGCACCC AATTCCGGGA GAACAACAGT TCCAATCTCT CTCCAAACAT GACGTCGCCG AATGGCCCC? CTGCTTTCCA AGCTTCCTGG TGGCGGCTCT TC-AGAAAGAT ACCTACAAGC GGGCATCCCC TGGCAGGCTG CTCCTGCAGG

ACTTAAAGAG GAAGACGTCT GAGCTTCGTA CAATTCTTCG TCTCGACATC AAAACTGACG ACGTAGAGGG ACTATCAACC GGCTCCCGAG ACTTTGCCAC GCCCTGCAGC GCGCCGGGCA AGGTGTCGTA GGCGGCTCTC CCAGGGCGAT TGTGCCACCC TGGGCTCCCC CTTGAGCCAA CCCTGGAAGG 40 PMON13136

i ATGGCTA.^CT GCTCTAT^.T GATCGATGAA ATTATACATC ACTTAAAGAG 51 ACCACCTGCA CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT 45 101 CTATCCTGAT GGACCGAAAC CTTCGACTTC CAAACCTGGA GAGCTTCGTA

151' AGGGCTGTCA AGAACTTAGA AAATGCATCA GGTATTGAGG CAATTCTTCG 201 TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC TCTCGACATC 251 CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG 301 TTCTATCTGG TTACCCTTGA> GCAAGCGCAC- G.^C^CAGT ACGTAGAGGG 50 351 CGGTGGAGGC TCCCCGGGTG GTGGTTCTGG CGGCGGCTCC AACATGGCTA

401 TGGCCCCTGC CCTGCAG'CCC ACCCAGGGTG CCATGCCGGC CTTCGCCTCT 451 GCTTTCCAGC GCCGGGCAGG AGGGGTCCTG GTTGCTAGCC ATCTGCAGAG 501 CTTCCTGGAG GTGTCGTACC GCGTTCTACG CCACCTTGCG CAGCCCTCTG 551 GCGGCTCTGG CGGCTCTCAG AGCTTCCTGC TCA-^GTCTTT AGAGCA^C-TG 55 601 AGAAAGATCC AGGGCGATGG CGCAGCGCTC CAGGAGAAC-C TGTGTGCCAC

651 CTACAAGCTG TGCCACCCCG AGGAGCTGGT GCTGCTCGGA CACTCTCTGG 701 GCATCCCCTG GGCTCCCCTG AGCTCCTGCC CCAGCCAGGC CCTGCAGCTG 751 GCAGGCTGCT TGAGCCAACT CCATAGCGGC CTTTTCCTCT ACCAGGGGCT 301 CCTGCAGGCC CTGG^GGGA TATCCCCCGA GTTGGGTCCC ACCTTGGACA 60 351 CACTGCAGCT GGACGTCGCC GACTTTGCCA CCACCATCTG GCAGCAGATG 901 GAAGAACTGG GATΑΛΤΑΑ SEQ ID MO:21 65 pMOM13IS^ 70 75 51 101 151 201 251 30 L 3 5 i 40L 451

,-ΤΛ ^ '广 ΓΤΊ .'Λ * Λ/Λν, l ACCACCTGCA T AT C C T G AT '/、、产一广、 L L A TAATCTCCAA C C ATC AT rn ' rr*/<^nn 广广 ·* * ·»» ▲ ·*~\ ▲丄\ j ,/*> .*-» \ CGTCTCCTCC CCTGCCCTGC

GCTCTATAAT CCTTTGCTGG GGACCGAAAC 广 m rr» ' 广， i 二CCATGTCTGC CAAGGCAGGT TTACCCTTGA TCCCCGGGTG GTCTAAAGAA AGCCCACCCA

GATCGATGAA ACCCGAACAA CTTCGACTTC AAATGCATCACCTCTGCCAC GACTGGCAAG GCAAGCGCAG AACCGTCTGG TCTCATAAAT GGGTGCCATG

ATTATACATC CCTCAATGAC CAAACCTGGA GGTATTGAGGGGCCGCACCC AATTCCGGGA GAACAACAGT TCCAATCTCT CTCCAAACAT CCGGCCTTCG

ACTTAAAGAG GAAGACGTCT GAGCTTCGTA CAATTCTTCGTCTCGACATC AAAACTGACG ACGTAGAGGG ACTATCAACC GGCTATGGCC CCTCTGCTTT -Il3 -

O:\92\92747.DOC 200413407 10 501 551 601 651 701 751 .301 851 901 951

CCAGCGCCGG TGGAGGTGTC TCTGGCGGCT GATCCAGGGC AGCTGTGCCA CCCTGGGCTC CTGCTTGAGC AGGCCCTGGA CAGCTGGACG ACTGGGAT.^A

> y-> z-' ^ GTACCGCGTT CTCAGAGCTT GATGGCGCAG CCCCGAGGAG CCCTGAGCTC CAACTCCATA AGGGATATCC TCGCCGACTT TAA SEQ ID TCCTGGTTGC CTACGCCACC CCTGCTCAAG CGCTCCAGGA CTGGTGCTGC CTGCCCCAGC GCGGCCTTTT CCCGAGTTGG TGCCACCACC MO : 2 2

TAGCCATCTG TTGCGCAGCC TCTTTAGAGC GPu^GCTGTGT TCGGACACTC CAGGCCCTGC CCTCTACCAG GTCCCACCTT ATCTGGCAGC

CAGAGCTTCC CTCTGGCGGC AAGTGAGAAA GCCACCTACA TCTGGGCATC AGCTGGCAGG GGGCTCCTGC GGACACACTG AGATGGAAGA OM0N13133 5 o 3 1 r丄 ΊΊ 1—Ϊ 1~f r--4·i—^t—I r-ir-上 Γ1i'I ϊ""f rH Ti「4 >5 050 5 05050 5 05050 I 1 2 2 3 3 4 4 5 IP 6 6 7 7 00 CD 9

ATGGCTAACT ACCACCTGCA CTATCCTGAT AGGGCTGTCA TAATCTCCAA CAATCATCAT TTCTATCTGG CGGTGGAGGC CCCAGGGTGC GGGGTCCTGG CGTTCTACGC GCTTCCTGCT GCAGCGCTCC GGAGCTGGTG GCTCCTGCCC CATAGCGGCC ATCCCCCGAG ACTTTGCCAC GCCCTGCAGC GCTCTAT.\AT CCTTTGCTGG GGACCGAAAC AGAACTTAGA CCATGTCTGC CAAGGCAGGT TTACCCTTGA TCCCCGGGTG CATGCCGGCC TTGCTAGCCA CACCTTGCGC CAAGTCTTTA AGGAGAAGCT CTGCTCGGAC CAGCCAGGCC TTTTCCTCTA TTGGGTCCCA CACCATCTGG CCTAATAA S: GATCGATGAA ACCCGAACAA CTTCGACTTC AAATGCATCA CCTCTGCCAC GACTGGCAAG GCAAGCGCAG GTGGTTCTGG TTCGCCTCTG TCTGCAGAGC AGCCCTCTGG GAGCAAGTGA GTGTGCCACC ACTCTCTGGG CTGCAGCTGG CCAGGGGCTC CCTTGGACAC CAGCAGATGG ：Q ID NO: 23

ATTATACATC CCTCAATGAC CAAACCTGGA GGTATTGAGG GGCCGCACCC AATTCCGGGA GAACAACAGT CGGCGGCTCC CTTTCCAGCG TTCCTGGAGG CGGCTCTGGC GAAAGATCCA TACAAGCTGT CATCCCCTGG CAGGCTGCTT CTGCAGGCCC ACTGCAGCTG AAGAACTGGG

ACTTAAAGAG GAAGACGTCT GAGCTTCGTA CAATTCTTCG TCTCGACATC AAAACTGACG ACGTAGAGGG AACATGGCTA CCGGGCAGGA TGTCGTACCG GGCTCTCAGA GGGCGATGGC GCCACCCCGA GCTCCCCTGA GAGCCAACTC TGGAAGGGAT GACGTCGCCG AATGGCCCCT 35 PMON131B9 40 45 50 1 51 101 151 2〇1 251 301 351 401* 451 501 551 601 551 701 751 301 351 901 951

ATGGCTAACT ACCACCTGCA CTATCCTGAT AGGGCTGTCA TAATCTCCAA CAATCATCAT TTCTATCTGG CGGTGGAGGC CGTCTCCTCC GGTGCCATGC CCTGGTTGCT TACGCCACCT CTGCTCAAGT GCTCCAGGAG TGGTGCTGCT TGCCCCAGCC CGGCCTTTTC CCGAGTTGGG GCCACCACCA GCAGCCCTAA

GCTCTATAAT CCTTTGCTGG GGACCGAAAC AGAACTTAGA CCATGTCTGC CAAGGCAGGT TTACCCTTGA TCCCCGGGTG GTCTAAAGAA CGGCCTTCGC AGCCATCTGC TGCGCAGCCC, CTTTAGAGCA AAGCTGTGTG CGGACACTCT AGGCCCTGCA CTCTACCAGG TCCCACCTTG TCTGGCAGCA TAA 5EQ ID GATCGATGAA A.CCCGAACAA CTTCGACTTC AAATGCATCA CCTCTGCCAC GACTGGCAAG GCAAGCGCAG AACCGTCTGG TCTCATAAAT CTCTGCTTTC AGAGCTTCCT TCTGGCGGCT AGTGAGAAAG CCACCTACAA CTGGGCATCC GGCTCCTGCA GACACACTGC NO : 2 4

ATTATACATC CCTCAATGAC CAAACCTGGA GGTATTGAGG GGCCGCACCC AATTCCGGGA GAACAACAGT TCCAATCTCT CTCCAAACAT CAGCGCCGGG GGAGGTGTCG CTGGCGGCTC ATCCAGGGCG GCTGTGCCAC CCTGGGCTCC TGCTTGAGCC AGCTGGACGT CTGGGAATGG ACTTAAAGAG GAAGACGTCT GAGCTTCGTA CAATTCTTCG TCTCGACATC AAAACTGACG ACGTAGAGGG ACTATCAACC GGCTACCCAG CAGGAGGGGT TACCGCGTTC TCAGAGCTTC ATGGCGCAGC CCCGAGGAGC CCTGAGCTCC AACTCCATAG GGGATATCCC CGCCGACTTT 广^广rn广，rp r 〇广，ryi

60 CMON13190 65 70 51 101 i 5 1 201 251 301 351 401 451 501 551 601 551

ATGGCTAACT ACCACCTGCA CTATCCTGAT AGGGCTGTCA TAATCTCCAA CAATCATCAT TTCTATCTGvG CGGTGGAGGCCTGCTTTCCA AGCTTCCTGG TGGCGGCTCT TGAGAA^\GAT ACCTACAAGC CGGCATCCCC

GCTCTATAAT CCTTTGCTGG GGACCGAAAC AGAACTTAGA CCATGTCTGC CAAGGCAGGT TTACCCTTGA TCCCCGGGTG 、,·—· m ^ ^ i Ο l L. I ΓΛ GGCGGCTCTC CCAGGGCGAT TGTGCCACCC TGGGCTCCCC

GATCGATGAA ACCCGAACAA CTTCGACTTC AAATGCATCA CCTCTGCCAC GACTGGCAAG GCAAGCGCAG GTGGTTCTGGGGAGGGGTCC CCGCGTTCTA AGAGCTTCCT GGCGCAGCGC CGAGGAGCTG TGAGCTCCTG

ATTATACATC CCTCAATGAC CAAACCTGGA GGTATTGAGG GGCCGCACCC AATTCCGGGA GAACAACAGT CGGCGGCTCCTGGTTGCTAG CGCCACCTTG GCTCAAGTCT TCCAGGAGAA GTGCTGCTCG CCCCAGCCAG

ACTTAAAGAG 'GAAGACGTCT GAGCTTCGTA CAATTCTTCG TCTCGACATC AAAACTGACG ACGTAGAGGG AACATGGCTTCCATCTGCAG CGCAGCCCTC TTAGAGCAAG GCTGTGTGCC GACACTCTCT GCCCTGCAGC

O:\92\92747.DOC 114- 200413407 701 TGGCAGGCTG CTTGAGCC^ CTCCATAGCG GCCTTTTCCT CTACCAGGGG 751 CTCCTGCAGG CCCTGGAAGG GATATCCCCC GAGTTGGGTC CCACCTTGGA 301 CACACTGCAG CTGGACGTCG CCGACTTTGC CACCACCATC TGGCAGCAGA 351 TGG^GAACT GGGAATGGCC CCTGCCCTGC AGCCCACCCA GGGTGCCATG 901 CCGGCCTTCG CCTAATAA SEQ ID MO :25

PxMONl3i91 10 i 51 101 151 201 15 251 301 351 401 451 20 501 551 601 651 7 01 25 751 301 351 901 951 30

ATGGCTAACT

ACCACCTGCA

CTATCCTGAT

AGGGCTGTCA

TAATCTCCAA

CAATCATCAT

TTCTATCTGG

CGGTGGAGGC

CGTCTCCTCC

TTCCAGCGCC

CCTGGAGGTG

GCTCTGGCGG

AAGATCCAGG

CAAGCTGTGC

TCCCCTGGGC

GGCTGCTTGA

GCAGGCCCTG

TGCAGCTGGA

GAACTGGGAA

CTTCGCCT.\A

GCTCTATAAT CCTTTGCTGG GGACCGAAAC AGAACTTAGA CCATGTCTGC CAAGGCAGGT TTACCCTTGA TCCCCGGGTG GTCTAAAGAA GGGCAGGAGG TCGTACCGCG CTCTCAGAGC GCGATGGCGC CACCCCGAGG TCCCCTGAGC GCCAACTCCA GAAGGGATAT CGTCGCCGAC TGGCCCCTGC TAA SEQ ID

GATCGATGAA

ACCCGAACAA

CTTCGACTTC

AAATGCATCA

CCTCTGCCAC

GACTGGCAAG

GCAAGCGCAG

AACCGTCTGG

TCTCATAAAT

GGTCCTGGTT

TTCTACGCCA

TTCCTGCTCA

i 'w.n.U

AGCTGGTGCT

TCCTGCCCCA

TAGCGGCCTT

CCCCCGAGTT

TTTGCCACCA

CCTGCAGCCC ΝΟ：2δ

ATTATACATC

CCTCAATGAC

CAAACCTGGA

C-GTATTGAGG

GGCCGCACCC

AATTCCGGGA

GAACAACAGT

TCCAATCTCT

CTCCAAACAT

GCTAGCCATC

CCTTGCGCAG

AGTCTTTAGA

GAGAAGCTGT

GCTCGGACAC

GCCAGGCCCT

TTCCTCTACC

GGGTCCCACC

CCATCTGGCA

ACCCAGGGTG

ACTTAAAGAG

GAAGACGTCT

GAGCTTCGTA

CAATTCTTCG

TCTCGACATC

AAAACTGACG

ACGTAGAGGG

ACTATCAACC

GGCTTCTGCT

TGCAGAGCTT

CCCTCTGGCG

GCAAGTGAGA

GTGCCACCTA

TCTCTGGGCA

GCAGCTGGCA

AGGGGCTCCT

TTGGACACAC

GCAGATGGAA

CCATGCCGGC

35 40 45 50 PMOM13192 i ATGGCT.\ACT GCTCTAT.\AT GATCGATGAA ATTATACATC ACTTAAAGAG 51 ACCACCTGCA CCTTTGCTGG ACCCGAACAA CCTCAATGAC GA^.GACGTCT 101 CTATCCTGAT GGACCGAAAC CTTCGACTTC CAAACCTGGA GAGCTTCGTA 151 AGGGCTGTCA AGAACTTAGA AAATGCATCA GGTATTGAGG CAATTCTTCG 201 TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC TCTCGACATC 251 CMTCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG 301 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG 351 CGGTGGAGGC TCCCCGGGTG GTGGTTCTGG CGGCGGCTCC ^CATGGCTT 401 AC^GCTGTG CCACCCCGAG GAGCTGGTGC TGCTCGGACA CTCTCTGGGC 451 ATCCCCTGGG CTCCCCTGAG CTCCTGCCCC AGCCAGGCCC TGCAGCTGGC 501 AGGCTGCTTG AGCCA.\CTCC ATAGCGGCCT TTTCCTCTAC CAGGGGCTCC 5 51- TGCAGGCCCT GGAi.GGGATA TCCCCCGAGT TGGGTCCCAC CTTGGACACA 601 CTGCAGCTGG ACGTCGCCGA CTTTGCCACC ACCATCTGGC AGCAGATGGA 651 AG^CTGGGA ATGGCCCCTG CCCTGCAGCC CACCCAGGGT GCCATGCCGG 701 CCTTCGCCTC TGCTTTCCAG CGCCGGGCAG GAGGGGTCCT GGTTGCTAGC 751 CATCTCCAGA GCTTCCTGGA^ GGTGTCGTAC CGCGTTCTAC GCCACCTTGC 801 GCAGCCCACA CCATTGGGCC CTGCCAGCTC CCTGCCCCAG AGCTTCCTGC 351 TCAAGTCTTT AGAGCA.-.GTG AGAAAGATCC AGGGCGATGG CGCAGCGCTC 901 CAGGAGAAGC TGTGTGCCAC CTAATAA SEQ ID MC:27

55 pMON13193 60 65 70 75

1 ATGGCT.^CT GCTCTAT.^AT GATCGATGAA ATTATACATC ACTTAAAGAG 51 ACCACCTGCA CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT 1 {Λ 1 ,·-> m rp rn > rn Γτ-ι m nn λ 广、广/m m p,一 γή ' 丄 J 丄 x ^ ^ ^ ·〇Λ 1 LjLjrtLLj^ i 1 l L λ 二 i Lu 丄 n 151 AGGGCTGTCA AGAACTTAGA AAATGCATCA GGTATTGAGG CAATTCTTCG 201 TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC TCTCGACATC "51 CAATCATCAT CAAGGC;'GGT GACTGGCAAG AATTCCGGGA AAAACTGACG 301 TTCTATCTGG TTACCCTTGA GCP^GCGCAG G^CAACAGT ACGTAGAGGG 351 CGGTGGAGGC TCCCCGGGTG AACCGTCTGG TCCAATCTCT ACTATCAACC 401 CGTCTCCTCC GTCTAAAGAA TCTCATPvAAT CTCCAAACAT GGCTTACAAG 451 CTGTGCCACC CCGAGGAGCT GGTGCTGCTC GGACACTCTC TGGGCATCCC 501 CTGGGCTCCC CTGAGCTCCT GCCCCAGCCA GGCCCTGCAG CTGGCAGGCT 551 OCTTGAGCCA ACTCCATAGC GGCCTTTTCC TCTACCAGGG GCTCCTGCAG 60 L Gv：CCTCGAAG GGATATCCCC CGAGTTGGGT CCCACCTTGG ACACACTGCA *3 51 0C7GGACGTC GCCGACTTTG CCACCACCAT CTGGCAGCAG ；VTGGAAGAAC 701 ..rGGGAATGGC CCCTGCCCTG CAGCCCACCC AGGGTGCCAT GCCGGCCTTC 1 GCCTCTGCTT TCCAGCGCCG GGCAGGAGGG GTCCTGGTTG CTAGCCATCT 301 OCAGACCTTC CTGGAGGTGT CCTACCGCGT TCTACGCCAC CTTGCGCAGC BS L CCACACCATT GGGCCCTGCC AGCTCCCTGC CCCAGAGCTT CCTGCTCAAG 301 TCTTTAGAGC .^GTGAG.AAA GATCCAGGGC GATGGCGCAG CGCTCCAGGA -115 -

O:\92\92747.DOC 200413407 GAAGCTGTGT GCCACCTAAT ΛΑ SEQ ID NO :28 PMON25190 10 15 20 25 1 ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG 51 ACCACCTGCA CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT iOl CTATCCTGAT GGACCGAAAC CTTCGACTTC C.\AACCTGGA GAGCTTCGTA 151 AGGGCTGTCA AGAACTTAGA AAATGCATCA GGTATTGAGG C.^ATTCTTCG 201 TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC TCTCGACATC 251 CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG 301 TTCTATCTGG TTACCCTTGA GCAAGCGCAG G^CAACAGT ACGTAGAGGG 351 CGGTGGAGGC TCCCCGGGTG GTGGTTCTGG CGGCGGCTCC AACATGGCTC 401 CCGAGTTGGG TCCCACCTTG GACACACTGC AGCTGGACGT CGCCGACTTT 451 GCCACCACCA TCTGGCAGCA GATGGAAG^A CTGGGAATGG CCCCTGCCCT 501 GCAGCCCACC CAGGGTGCCA TGCCGGCCTT CGCCTCTGCT TTCCAGCGCC 551 GGGCAGGAGG GGTCCTGGTT GCTAGCCATC TGCAGAGCTT CCTGGAGGTG 601 TCGTACCGCG TTCTACGCCA CCTTGCGCAG CCCACACCAT TGGGCCCTGC 651 CAGCTCCCTG CCCCAGAGCT TCCTCCTCAA GTCTTTAGAG CAAGTGAGAA 701 AGATCCAGGG CGATGGCGCA GCGCTCCAGG AGAAGCTGTG TGCCACCTAC 751 .\AGCTGTGCC ACCCCGAGGA GCTGGTGCTG CTCGGACACT CTCTGGGCAT 301 CCCCTGGGCT CCCCTGAGCT CCTGCCCCAG CCAGGCCCTG CAGCTGGCAG 851 GCTGCTTGAG CCAACTCCAT AGCGGCCTTT TCCTCTACCA GGGGCTCCTG 901 CAGGCCCTGG AAGGGATATC CTAATAA SEQ ID NO：29 CHON25191 o 3 5 3 5 0 5 0 5 0 rl Ί·*-「厶 Ί) 5 0 5 3 4 4 40 5 4 0 5 0 5 0 5 0 5 0 5 5 5 6 6 7 7 3 8 9 9 ATGGCT.\ACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG ACCACCTGCA CCTTTGCTGG ACCCGAAC.^A CCTCAATGAC GAAGACGTCT CTATCCTGAT GGACCGAAAC CTTCGACTTC CAJUCCTGGA GAGCTTCGTA AGGGCTGTCA AGAACTTAGA AAATGCATCA GGTATTGAGG C.\ATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG CGGTGGAGGC TCCCCGGGTG AACCGTCTGG TCCAATCTCT ACTATCAACC CGTCTCCTCC GTCTAAAGAA TCTCATAAAT CTCCAAACAT GGCTCCCGAG TTGGGTCCCA CCTTGGACAC ACTGCAGCTG GACGTCGCCG ACTTTGCCAC CACCATCTGG CAGCAGATGG AAGAACTGGG AATGGCCCCT GCCCTGCAGC CCACCCAGGG TGCCATGCCG GCCTTCGCCT CTGCTTTCCA GCGCCGGGCA GGAGGGGTCC TGGTTGCTAG CCATCTGCAG AGCTTCCTGG AGGTGTCGTA CCGCGTTCTA CGCCACCTTG CGCAGCCCAC ACCATTGGGC CCTGCCAGCT CCCTGCCCCA GAGCTTCCTG CTC*\AGTCTT TAGAGCAAGT GAGAAAGATC CAGGGCGATG GCGCAGCGCT CCAGGAGAAG CTGTGTGCCA CCTACAAGCT GTGCCACCCC GAGGAGCTGG TGCTGCTCGG ACACTCTCTG GGCATCCCCT GGGCTCCCCT GAGCTCCTGC CCCAGCCAGG CCCTGCAGCT GGCAGGCTGC TTGAGCC.^AC TCCATAGCGG CCTTTTCCTC TACCAGGGGC TCCTGCAGGC CCTGGAAGGG ATATCCTAAT、ΑΛ SEQ ID NO :30 o 5 ΌΜΟΝ13Ι94

60 65 ：)丄 101 151 201 251 301 251 401 451 501 551 601 651 70 301 ^51 901

A.TGGCTAACT ACCACCTGCA CTATCCTGAT AGGGCTGTCA TAATCTCCAA CAATCATCAT TTCTATCTGG CGGTGGAGGC TGGCCCCTGC GCTTTCCAGC CTTCCTGGAG CATTGGGCCC GAGCAAGTGA GTGTGCCACC ACTCTCTGGG CTGCAGCTGGCCAGGGGCTC CCTTGGACAC CAGCAGATGG

r1*.产、mr>rp、rn' 'rp Ο λ i Λ. CCTTTGCTGG GGACCGAAAC AGAACTTAGA CCATGTCTGC CAAGGCAGGT TTACCCTTGA TCCCCGGGTG CCTGCAGCCC GCCGGGCAGG GTGTCGTACC TGCCAGCTCC GAAAGATCCA TACAAGCTGT CATCCCCTGG CAGGCTGCTTCTGCAGGCCC ACTGCAGCTG AAGAACTGGG GATCGATG^ ATTATACATC ACCCGAACAA CCTCAATGAC CTTCGACTTC CAAACCTGGA AAATGCATCA GGTATTGAGG CCTCTGCCAC GGCCGCACCC GACTGGCAAG AATTCCGGGA GCAAGCGCAG GAACAACAGT GTGGTTCTGG CGGCGGCTCC ACCCAGGGTG CCATGCCGGC AGGGGTCCTG GTTGCTAGCC GCGTTCTACG CCACCTTGCG CTGCCCCAGA GCTTCCTGCT GGGCGATGGC GCAGCGCTCC GCCACCCCGA GGAGCTGGTG GCTCCCCTGA GCTCCTGCCC GAGCCAACTC CATAGCGGCC TGGA.AGGGAT ATCCCCCGAG GACGTCGCCG ACTTTGCCAC ΑΤΑΑΤΛΑ S^Q ID MO :31

'广^nm、飞'|^'广 GAAGACGTCT GAGCTTCGTA CAATTCTTCG TCTCGACATC AAAACTGACG ACGTAGAGOG AACATGGCTA CTTCGCCTCT ATCTGCAGAG CAGCCCACAC CAAGTCTTTA AGGAGAAGCT CTGCTCGGAC CAGCCAGGCC TTTTCCTCTATTGGGTCCCA CACCATCTGG 75 pMOM13195

O:\92\92747.DOC -116- 5 I0 5 o 2 L 1 X I—< r—i 1 r-上 f—* T—f r--< *—i l-ir--1·-—t ϊ—- 1x <~1 人 5 o 5 〇 5 o 5 o 5 o 5 o 5 o 5 G 5 o 5 1 1 22 3 3 4 4 5 5 Vo 6 7 7 Co 8 9 9

ATGGCTAACT ACCACCTGCA CTATCCTGAT AGGGCTGTCA TAATCTCCAA CAATCATCAT TTCTATCTGG CGGTGGAGGC CGTCTCCTCC CCTGCCCTGC CCAGCGCCGG TGGAGGTGTC GGCCCTGCCA AGTGAGAAAG CCACCTACAA CTGGGCATCC GCTGGCAGGC GGCTCCTGCA GACACACTGC GATGGAAGAA

GCTCTATAAT CCTTTGCTGG GGACCGAAAC AGAACTTAGA CCATGTCTGC CAAGGCAGGT TTACCCTTGA TCCCCGGGTG GTCTAAAGAA AGCCCACCCA OLALjO-rvljOLrO GTACCGCGTT GCTCCCTGCC ATCCAGGGCG GCTGTGCCAC CCTGGGCTCC TGCTTGAGCC AGCTGGACGT CTGGGATAAT GATCGATGAA ACCCGAACAA CTTCGACTTC AAATGCATCA CCTCTGCCAC GACTGGCAAG GCAAGCGCAG AACCGTCTGG TCTCATAAAT GGGTGCCATG TCCTGGTTGC CTACGCCACC CCAGAGCTTC ATGGCGCAGC CCCGAGGAGC CCTGAGCTCC AACTCCATAG GGGATATCCC CGCCGACTTT AA 3EQ ID : ATTATACATC CCTCAATGAC CAAACCTGGA GGTATTGAGG GGCCGCACCC AATTCCGGGA GAACAACAGT TCCAATCTCT CTCCAAACAT CCGGCCTTCG TAGCCATCTG TTGCGCAGCC CTGCTCAAGT GCTCCAGGAG TGGTGCTGCT TGCCCCAGCC CGGCCTTTTC CCGAGTTGGG GCCACCACCA JO :32

ACTTAAAGAG GAAGACGTCT GAGCTTCGTA CAATTCTTCG TCTCGACATC AAAACTGACG ACGTAGAGGG ACTATCAACC GGCTATGGCC CCTCTGCTTT CAGAGCTTCC CACACCATTG CTTTAGAGCA AAGCTGTGTG CGGACACTCT AGGCCCTGCA CTCTACCAGG TCCCACCTTG TCTGGCAGCA PMON13196 25 30 35 40 1 1 1 L 1 1 1* 1 1 X 1 l· 1 5 0 5 0 5 0 5 0 5 0 5 0 5 0 5 0 5 0 12 2 3 3 4 4 LH L〇 voro 7 7 8 8 9

ATGGCTAACT ACCACCTGCA CTATCCTGAT TAATCTCCAA CAATCATCAT TTCTATCTGG CGGTGGAGGC CCCAGGGTGC GGGGTCCTGG CGTTCTACGC TGCCCCAGAG GGCGATGGCG CCACCCCGAG CTCCCCTGAG AGCCAACTCC GGAAGGGATA ACGTCGCCGA ATGGCCCCTG

GCTCTATAAT CCTTTGCTGG GGACCGAAAC AGAACTTAGA CCATGTCTGC CAAGGCAGGT TTACCCTTGA TCCCCGGGTG CATGCCGGCC TTGCTAGCCA CACCTTGCGC CTTCCTGCTC CAGCGCTCCA GAGCTGGTGC CTCCTGCCCC ATAGCGGCCT TCCCCCGAGT CTTTGCCACC CCCTGCAGCC GATCGATGAA ACCCGAACAA CTTCGACTTC AAATGCATCA CCTCTGCCAC GACTGGCAAG GCAAGCGCAG GTGGTTCTGG TTCGCCTCTG TCTGCAGAGC AGCCCACACC AAGTCTTTAG GGAGAAGCTG TGCTCGGACA AGCCAGGCCC TTTCCTCTAC TGGGTCCCAC ACCATCTGGC CTAATAA SE·： ATTATACATC CCTCAATGAC CAAACCTGGA GGTATTGAGG GGCCGCACCC AATTCCGGGA GAACAACAGT CGGCGGCTCC CTTTCCAGCG TTCCTGGAGG ATTGGGCCCT AGCAAGTGAG TGTGCCACCT CTCTCTGGGC TGCAGCTGGC CAGGGGCTCC CTTGGACACA AGCAGATGGA )ID NO:33

ACTTAAAGAG GAAGACG丁CT GAGCTTCGTA CAATTCTTCG TCTCGACATC AAAACTGACG ACGTAGAGGG AACATGGCTA CCGGC-CAGGA TGTCGTACCG GCCAGCTCCC AAAGATCCAG ACAAGCTGTG 、rp广广广^ «^严丄 L L Λ 广，广广 rp rn TGCAGGCCCT CTGCAGCTGG AGAACTGGGA 45 PMON13197 l 1 l l l l 1 l 1 1 l L l 1 l l 1 1 5 0 5050 5 050 5 0505050 5 i l· 2 2 3 3 4 4 5 LH ό 6 7 7 8 CO 9 9 50556065

A.TGGCTAACT

ACCACCTGCA

CTATCCTGAT

AGGGCTGTCA

TAATCTCCAA

CAATCATCAT

TTCTATCTGG

CGGTGGAGGC

CGTCTCCTCC

GGTGCCATGC

CCTGGTTGCT

TACGCCACCT

CAGAGCTTCC

TGGCGCAGCG

CCGAGGAGCT

CTGAGCTCCT

ACTCCATAGC

GGATATCCCC

GCCGACTTTG

CCCTGCCCTG

GCTCTATAAT CCTTTGCTGG、

GGACCGAAAC

AGAACTTAGA

CCATGTCTGC

CAAGGCAGGT

TTACCCTTGA

TCCCCGGGTG

GTCTAAAGAA

CGGCCTTCGC

AGCCATCTGC

TGCGCAGCCC

TGCTCAAGTC

CTCCAGGAGA

GGTGCTGCTC

GCCCCAGCCA

GGCCTTTTCC

CGAGTTGGGT

CCACCACCAT

CAGCCCTAAT mr^ Λ mr^ ^ ^ ν_7Λ x

ACCCGAACAA

CTTCGACTTC 、、· .-π，-» Λ CCTCTGCCAC GACTGGCAAG GCAAGCGCAG AACCGTCTGG TCTCATAAAT CTCTGCTTTC AGAGCTTCCT ACACCATTGG TTTAGAGCAA AGCTGTGTGC GGACACTCTC GGCCCTGCAG TCTACCAGGG CCCACCTTGG CTGGCAGCAG ΛΑ 3EQ ID '

ATTATACATC

CCTCAATGAC

CAAACCTGGA

GGTATTGAGG ό ^ L- ·〇 L· /Λ L· AATTCCGGGA GAACAACAGT TCCAATCTCT CTCCAAACAT CAGCGCCGGG GGAGGTGTCG GCCCTGCCAG GTGAGAAAGA CACCTACAAG TGGGCATCCC CTGGCAGGCT GCTCCTGCAG ACACACTGCA ATGGAAGAAC \rO : 3 4

ACTTAAAGAG

GAAGACGTCT

GAGCTTCGTA

CAATTCTTCG

TCTCGACATC

AAAACTGACG

ACGTAGAGGG

ACTATCAACC

GGCTACCCAG

CAGGAGGGGT

TACCGCGTTC

CTCCCTGCCC

TCCAGGGCGA

CTGTGCCACC

CTGGGCTCCC

GCTTGAGCCA

GCCCTGGAAG

GCTGGACGTC

TGGGAATGGC 70 pMCM1319：^

I ATGGCT.-\ACT GCTCTATAAT GATCGATGA.A ATTATACATC ACTTAAAGAG 5 1 ACCACCTGCA CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGAC.GTCT 101 CTATCCTGAT GGACCGA.\AC CTTCGACTTC C.\AACCTGGA GAGCTTCGTA 75 151 AGGGCTGTCA AGAACTTAGA AA^TGCATCA GGTATTGAGG CP^TTCTTCG -117-

O:\92\92747.DOC 200413407 l0 -445565^ 5 -IX t— ί T~'ί Ί丄 1—I -05050 7 3 CO 9

TAATCTCCAA CAATCATCAT TTCTATCTGG CGGTGGAGGC CTGCTTTCCA AGCTTCCTGG ACCATTGGGC TAGAGCAAGT CTGTGTGCCA ACACTCTCTG CCCTGCAGCT TACCAGGGGC CACCTTGGAC GGCAGCAGAT GGTGCCATGC

CCATGTCTGC CAAGGCAGGT TTACCCTTGA TCCCCGGGTG GCGCCGGGCA AGGTGTCGTA CCTGCCAGCT GAGAAAGATC CCTACAAGCT GGCATCCCCT GGCAGGCTGC TCCTGCAGGC ACACTGCAGC GGAAGAACTG CGGCCTTCGC CCTCTGCCAC GACTGGCAAG GCAAGCGCAG GTGGTTCTGG GGAGGGGTCC CCGCGTTCTA CCCTGCCCCA CAGGGCGATG GTGCCACCCC GGGCTCCCCT TTGAGCCAAC CCTGGAAGGG TGGACGTCGC GGAATGGCCC CTAATAA SE'. GGCCGCACCC AATTCCGGGA GAACAACAGT CGGCGGCTCC TGGTTGCTAG CGCCACCTTG GAGCTTCCTG GCGCAGCGCT GAGGAGCTGG GAGCTCCTGC TCCATAGCGG ATATCCCCCG CGACTTTGCC CTGCCCTGCA )ID NO :3 5

TCTCGAC.\TC AAAACTGACG ACGTAGAGGG AACATGGCTT CCATCTGCAG CGCAGCCCAC CTCAAGTCTT CCAGGAGAAG TGCTGCTCGG CCCAGCCAGG CCTTTTCCTC AGTTGGGTCC ACCACCATCT GCCCACCCAG pMON13i99 20 25 30 35 40 D 1 101 151 201 251 301 351 401 451 501 551 601 〇51 7 01 751 801 851 901 951

ATGGCTAACT ACCACCTGCA CTATCCTGAT AGGGCTGTCA TAATCTCCAA CAATCATCAT TTCTATCTGG CGGTGGAGGC CGTCTCCTCC 广、^ ^ 1 ‘ CCTGGAGGTG TGGGCCCTGC CAAGTGAGAA i. vjrL. 'w riC ^ i CTCTGGGCAT CAGCTGGCAG GGGGCTCCTG TGGACACACT CAGATGGAAG CATGCCGGCC

GCTCTATAAT CCTTTGCTGG GGACCGAAAC AGAACTTAGA CCATGTCTGC CAAGGCAGGT TTACCCTTGA TCCCCGGGTG GTCTAAAGAA GGGCAGGAGG TCGTACCGCG CAGCTCCCTG AGATCCAGGG AAGCTGTGCC CCCCTGGGCT GCTGCTTGAG CAGGCCCTGG GCAGCTGGAC AACTGGGAAT TTCGCCTAAT

GATCGATGAA ACCCGAACAA CTTCGACTTC AAATGCATCA CCTCTGCCAC GACTGGCAAG GCAAGCGCAG AACCGTCTGG TCTCATAAAT GGTCCTGGTT TTCTACGCCA CCCCAGAGCT CGATGGCGCA ACCCCGAGGA CCCCTGAGCT CCAACTCCAT AAGGGATATC GTCGCCGACT GGCCCCTGCC ΛΑ SEQ ID ATTATACATC CCTCAATGAC CAAACCTGGA GGTATTGAGG GGCCGCACCC AATTCCGGGA GAACAACAGT T广厂1 A Λ中P*""广τ CTCCAAACAT GCTAGCCATC CCTTGCGCAG TCCTGCTCAA GCGCTCCAGG GCTGGTGCTG CCTGCCCCAG AGCGGCCTTT CCCCGAGTTG TTGCCACCAC CTGCAGCCCA MO : 3 5

ACTTAAAGAG GAAGACGTCT GAGCTTCGTA CAATTCTTCG TCTCGACATC AAAACTGACG ACGTAGAGGG ACTATCAACC GGCTTCTGCT TGCAGAGCTT CCCACACCAT GTCTTTAGAG AGAAGCTGTG CTCGGACACT CCAGGCCCTG TCCTCTACCA C-GTCCCACCT CATCTGGCAG CCCAGC-GTGC pMOM31ii： 45 50 60 3i 101· 151201 251 301 351 401 451 501 551 501 551 701 751 301 851 901 951 ATGGCTAACT GCCACCGCTG ATATCCTAAT CGTGCTGTCA AAATCTCCTG CAATCCATAT TTCTATCTGA CGTCTCCTCC GGTGCCATGC CCTGGTTGCT TACGCCACCT CTGCTCAAGT GCTCCAGGAG TGGTGCTGCT TGCCCCAGCC CGGCCTTTTC v, ^ ； i oUo GCCACCACCA ,·-，·一广广 p 广、

GCTCTAAC.VT CCGCTGCTGG GGACAATAAC AGTCTCTGCA CCATGTCTGC CAAGGACGGT AAACCTTGGA' TCCCCGGGTG GTCTAAAGAA CGGCCTTCGC AGCCATCTGC ^^ ^ ^ ^ i u、丄· ： L I 'CTTTAGAGCA AAGCTGTGTG CGGACACTCT AGGCCCTGCA CTCTACCAGG TCCCACCTTG TCTGGCAGCA TAA SEQ ID GATCGATGAA ACTTCAACAA CTTCGTCGTC GAATGCATCA CGCTAGCCAC GACTGGAATG G.AACGCGCAG AACCGTCTGG TCTCATAAAT CTCTGCTTTC AGAGCTTCCT TCTGGCGGCT AGTGAGAAAG CCACCTACAA CTGGGCATCC GCTGGCAGGC GGCTCCTGCA GACACACTGC GATGGAAGAA NO : 3 7

ATCATCACCC CCTCAATGGT CAAACCTCGA GCAATTGAGA GGCCGCACCC ' ' rprp 广广广 •一丄 iL GCTCAACAGT TCCAATCTGT CTCCAAACAT CAGCGCCGGG GGAGGTGTCG CTGGCGGCTC ^ VJ V_J Ο GCTGTGCCAC CCTGGGCTCC TGCTTGAGCC GGCCCTGGAA AGCTGGACGT CTGGGAATGG

ACCTGAAGCA GAAGACCAAG GGCATTCAAC GCATTCTTAA ACGCGACATC TAAACTGACC ACGTAGAGGG ACTATCAACC GGCTACCCAG CAGGAGGGGT TACCGCGTTC /-n» 广nrirp/·^ * L· x i λ Λ ^ r\ I CCCGAGGAGC CCTGAGCTCC AACTCCATAG GGGATATCCC CGCCGACTTT CCCCTGCCCT 65 pMON3i.L13 70 75 l 5ί L01 LSI 201 25 1 301 •51 401 451 GCCACCGCTG ATATCCTGAT CGTGCTGTCA AAATCTCCTG C.^ATCATCAT TTCTATCTGA CGTCTCCTCC '^•vjT'oCC atgc

GCTCT.^CAT CCGCTGCTGG i·广一AGTCTCTGCA CCATGTCTGC CCGTGACGGT AAACCTTGGA T广广广广广广广np广 \ s ^ ^ Λ CGGCCTTCGC

Λ rr\r^r^ > rnr^ Λ Λ Lj 1 λ ACTTCAACAA CTTCGTCGTCGAATGCATCA CCCTGGCCAC GACTGGAATG GAACGCGCAG .AACCGTCTGG TCTCATAAAT CTCTGCTTTC

ATCATCACCC CCTCAATGGTGCAATTGAGA GGCCGCACCC AATTCCGTCG GCTCAACAGT TCCAATCTCT CTCCAAACAT CAGCGCCGGG

ACCTGAAGCA GAAGACCAAG GGCATTCAACGCATTCTTM ACGCGACATC TAAACTGACC ACGTAGAGGG ACTATCAACC GGCTACCCAG CAGGAGGGGT

O:\92\92747.DOC -118 · 200413407

TACCGCGTTC CTCCCTGCCC TCCAGGGCGA CTGTGCCACC CTGGGCTCCC GCTTGAGCCA GCCCTGGAAG GCTGGACGTC TGGGAATGGC 10 501 CCTGGTTGCT AGCCATCTGC AGAGCTTCCT GGAGGTGTCG 551 TACGCCACCT TGCGCAGCCC ACACCATTGG GCCCTGCCAG 601 CAGAGCTTCC TGCTCAAGTC TTTAGAGC.^A GTGAGAAAGA 651 TGGCGCAGCG CTCCAGGAGA AGCTGTGTGC CACCTACAAG 701 CCGAGGAGCT GGTGCTGCTC GGACACTCTC TGGGCATCCC 751 CTGAGCTCCT GCCCCAGCCA GGCCCTGCAG CTGGCAGGCT 801 ACTCCATAGC GGCCTTTTCC TCTACCAGGG GCTCCTGCAG 351 GGATATCCCC CGAGTTGGGT CCCACCTTGG ACACACTGCA 901 GCCGACTTTG CCACCACCAT CTGGCAGCAG ATGG^GAA.C 951 CCCTGCCCTG CAGCCCT.\AT AA SEQ ID NO: 3 3 ΌΜΟΝ31114 5 o 2 5 rl

-3 4 4 5 5 VO Vo I o 3 l IX X -_I -* 1 1 1--f 1—f i 1 1 rH 1 1 r上 1 5050505050 5 0 5050 111 5 0 5 8 3 9

ATGGCTAACT GCCACCGCTG ATATCCTGAT CGTGCTGTCA AAATCTCCTC* CAATCATCP^T TTCTATCTGA CGGTGGAGGC CGTCTCCTCC GGTGCCATGC CCTGGTTGCT TACGCCACCT CTGCTCAAGT GCTCCAGGAG TGGTGCTGCT TGCCCCAGCC CGGCCTTTTC CCGAGTTGGG GCCACCACCA GCAGCCCTAA

GCTCTAACAT CCGCTGCTGG GGAAAATAAC AGTCTCTGCA CCATGTCTGC CCGTGACGGT AAACCTTGGA TCCCCGGGTG GTCTAAAGAA CGGCCTTCGC AGCCATCTGC TGCGCAGCCC CTTTAGAGCA AAGCTGTGTG CGGACACTCT AGGCCCTGCA CTCTACCAGG TCCCACCTTG TCTGGCAGCA ΤΑΛ SEQ ID GATCGATGAA ACTTCAACAA CTTCGTCGTC GAATGCATCA CCCTGGCCAC GACTGGAATG GAACGCGCAG AACCGTCTGG TCTCATAAAT CTCTGCTTTC AGAGCTTCCT TCTGGCGGCT AGTGAGAAAG CCACCTACAA CTGGGCATCC GCTGGCAGGC GGCTCCTGCA GACACACTGC GATGGAAGAA MO :39

ATCATCACCC CCTCAATGGT CAAACCTCGA GCAATTGAGA GGCCGCACCC AATTCCGTCG GCTCAACAGT TCCAATCTCT CTCCAAACAT CAGCGCCGGG GGAGGTGTCG CTGGCGGCTC ATCCAGGGCG GCTGTGCCAC CCTGGGCTCC TGCTTGAGCC GGCCCTGGAA AGCTGGACGT CTGGGAATGG

ACCTGAAGCA GAAC-ACCAAG GGCATTCAAC GCATTCTTAA ACGCGACATC TAAACTGACC ACGTAGAGGG ACTATCAACC C-GCTACCCAG CAGGAGGGGT TACCGCGTTC TCAGAGCTTC ATGGCGCAGC CCTGAGCTCC AACTCCATAG GGGATATCCC CGCCGACTTT CCCCTGCCCT 5 3 DMOM31115 o 4 5 4 o 5 i 1111 11111111 -505050 5 5 ^—II·*·1X 一 -( 5 05050505050 505 0505 2 2 3 3 4 4 5 5 VD 6 7 7 3 3 9 9

ATGGCTAACT GCCACCGCTG ATATCCT.\AT CGTGCTGTCA AAATCTCCTG CAATCCATAT TTCTATCTGA CGGTGGAGGC CGTCTCCTCC GGTGCCATGC CCTGGTTGCT TACGCCACCT CAGAGCTTCC TGGCGCAGCG CCGAGGAGCT CTGAGCTCCT Λ ^ > m ^ /— W Λ GGATATCCCC GCCGACTTTG CCCTGCCCTG

GCTCTAACAT CCGCTGCTGG GGACAATAAC AGTCTCTGCA CCATGTCTGC CAAGGACGGT AAACCTTGGA TCCCCGGGTG GTCTAAAGAA CGGCCTTCGC AGCCATCTGC TGCGCAGCCC、 TGCTCAAGTC CTCCAGGAGA GGTGCTGCTC GCCCCAGCCA GGCCTTTTCC CGAGTTGGGT CCACCACCAT CAGCCCTAAT

GATCGATGAA ACTTCAACPVA CTTCGTCGTC GAATGCATCA CGCTAGCCAC GACTGGAATG GAACGCGCAG AACCGTCTGG TCTCATAAAT CTCTGCTTTC AGAGCTTCCT ACACCATTGG TTTAGAGCAA AGCTGTGTGC GGACACTCTC GGCCCTGCAG TCTACCAGGG CCCACCTTGG CTGGCAGCAG ΑΛ S£Q ID ATCATCACCC CCTCAATGGT CAAACCTCGA GCAATTGAGA GGCCGCACCC AATTCCGTCG GCTCAACAGT TCCAATCTCT CTCCAAACAT CAGCGCCGGG GGAGGTGTCG GCCCTGCCAG GTGAGAAAGA CACCTAC.\AG TGGGCATCCC CTGGCAGGCT vGCTCCTGCAG ACACACTGCA ATGGAAGAAC MO :40

ACCTGAAGCA GAAGACCAAG GGCATTCAAC GCATTCTTAA ACGCGACATC TAAACTGACC ACTATCAACC GGCTACCCAG CAGGAGGGGT TACCGCGTTC CTCCCTGCCC. TCCAGGGCGA CTGTGCCACC CTGGGCTCCC i. x GCCCTGGAAG GCTGGACGTC TGGGAATGGC 60 pMOM23505

GCTAACTGCTCTATAATGATCGATG^^TTATACATCACTT^^AGAGACCACCTGCACCTTTGCTGGACCCGAAC AACCTC.\ATGACG.\AGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCC.\PLiCCTGGAGAGCTTCGTAAGG GCTGTCA.\GA.^CTTAG^AA.^TGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCATGTCTGCCCTCTGCC 65 ACGGCCGCACCCTCTCGAC.VTCCAATCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCT： GGTCC^TCTCTACTATC.^CCCGTCTCCTCCGTCT.^AAGAATCTCAT^^ATCTCC^^CATCGAGGTTCACCCT TTGCCTACACCTGTCCTGCTGCCTGCTGTGGACTTTAGCTTGGGAGAATGG.\P«^CCCAGATGGAGGAGACC^G GCACAGGACATTCTGGGAGCAGTGACCCTTCTGCTGGAGGGAGTGATGGCAGCACGGGGACAACTGGGACCCACT 70 tgcctctcatccctcctggggcagctttctggacaggtccgtctcctccttggggccctgcagagcctccttgga acccagcttcctccacagggcaggaccacagctcac;^ggatccc^tgccatcttcctgagcttccaacacctg CTCCGAGGA^GGTGCGTTTCCTGATGCTTGTAGGAGGGTCCACCCTCTGCGTCAGGGAATTCGGCGGCAACATG GCGTCTCCCGCTCCGCCTGCTTGTGACCTCCGAGTCCTCAGTAAACTGCTTCGTGACTCCCATGTCCTTCACAGC AGACTGAGCCAGTGCCCA SEQ ID MO:4i 75 -119 -

O:\92\92747.DOC 200413407 pMON：3506 GCT.:\ACTGCTCTATAATGATCGATGAAATTATACATCACTTA.iJ\GAGACCACCTGCACCTTTGCTGGACCCGAA.C AACCTCAATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAGCTTCGTAAGG 5 GCTGTCAAGAACTTAGAAAATGC.VTCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCATGTCTGCCCTCTGCC ACGGCCGCACCCTCTCGACATCC^TCATCATC*^AGGCAGGTGACTGGC^G^TTCCGGGA.^\ACTGACGTTC TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCT GGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTC.VTAAATCTCCAAACATGTTGCCTACACCT GTCCTGCTGCCTGCTGTGGACTTTAGCTTGGGAGAATGGAAAACCCAGATGGAGGAGACCAAGGCACAGGACATT 10 CTGGGAGCAGTGACCCTTCTGCTGGAGGGAGTGATGGCAGCACGGGGAC^\CTGGGACCCACTTGCCTCTCATCC CTCCTGGGGCAGCTTTCTGGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGG.^CCCAGCTTCCT CCACAGGGCAGGACCACAGCTCAC^GGATCCC*\ATGCCATCTTCCTGAGCTTCCA.\CACCTGCTCCGAGGAAAG GTGCGTTTCCTGATGCTTGTAGGAGGGTCCACCCTCTGCGTCAGGGAATTCGGCGGC^CATGGCGTCTCCCGCT CCGCCTGCTTGTGACCTCCGAGTCCTCAGTAAACTGCTTCGTGACTCCCATGTCCTTCACAGCAGACTGAGCCAG 15 TGCCCAGAGGTTCACCCT SEQ ID NO：42 PMOM23507 20 25 30 GCT^CTGCTCTAT^TGATCGATGAAATTATACATCACTTA.\AGAGACCACCTGCACCTTTGCTGGACCCGAAC AACCTCAATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCAAACCTC-GAGAGCTTCGTW.GG GCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCATGTCTGCCCTCTGCC ACGGCCGCACCCTCTCGACATCC^TCATCATC.^AGGCAGGTGACTGGC^GAATTCCGGGAA-^CTGACGTTC TATCTGGTTACCCTTGAGCAAGCGCAGGAAC.\ACAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCT GGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGTCCTGCTGCCT' GCTGTGGACTTTAGCTTGGGAGAATGGAAAACCCAGATGGAGGAGACC^GGCACAGGACATTCTGGGAGCAGTG ACCCTTCTGCTGGAGGGAGTGATGGCAGCACGGGGAC^CTGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAG CTTTCTGGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGG.^CCCAGCTTCCTCCACAGGGCAGG ACCACAGCTCACAAGGATCCCAATGCCATCTTCCTGAGCTTCCAACACCTGCTCCGAGG^JL^GGTGCGTTTCCTG ATGCTTGTAGGAGGGTCCACCCTCTGCGTCAGGGPlATTCGGCGGCAACATGGCGTCTCCCGCTCCGCCTGCTTGT GACCTCCGAGTCCTCAGTA.\ACTGCTTCGTGACTCCCATGTCCTTCACAGCAGACTGAGCCAGTGCCCAGAGGTT CACCCTTTGCCTACACCT SEQ ID NO :43

CMGN2350S 35 GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTA^^GAGACCACCTGCACCTTTGCTGGACCCGAAC AACCTCAATGACGAAGACGTCTCTATCCTGATGGACCGA_\ACCTTCGACTTCCA^^CCTGGAGAGCTTCGT^GG GCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCATGTCTGCCCTCTGCC ACGGCCGCACCCTCTCGACATCCA.^TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC TATCTGGTTACCCTTGAGCAAGCGCAGGA*\CAACAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCT 40 GGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCTGTGGACTTT1 AGCTTGGGAGAATGGAAAACCCAGATGGAGGAGACCAAGGCACAGGACATTCTGGGAGCAGTGACCCTTCTGCTG GAGGGAGTGATGGCAGCACGGGGACAACTGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAGCTTTCTGGACAG GTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGCTTCCTCCACAGGGCAGGACCACAGCTCAC AAGGATCCCAATGCCATCTTCCTGAGCTTCCAACACCTGCTCCGAGG.^^AGGTGCGTTTCCTGATGCTTGTAGGA 45 GGGTCCACCCTCTGCGTCAGGGAATTCGGCGGC.\ACATGGCGTCTCCCGCTCCGCCTGCTTGTGACCTCCGAGTC CTCAGTA.\ACTGCTTCGTGACTCCCATGTCCTTCACAGCAGACTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCT ACACCTGTCCTGCTGCCT SEQ ID NO:44 50 55 60 PMCN23509 、 GCT^CTGCTCTATA^.TGATCGATGA^-ATTATACATCACTT^^GAGACCACCTGCACCTTTGCTGGACCCG^C AACCTCAAITGACGAAGACGTCTCTATCCTG^VrGGACCGAAACCTTCGACTTCCAAACCTGGPvGAGCTTCGTXAGG GCTGTC*\AG.\ACTTAGA.\AATGCATCAGGTATTGAGGCAATTCTTCGT^TCTCCA.^CCATGTCTGCCCTCTGCC ACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCA^.GAATTCCGGGAAAAACTGACGT'TC TATCTGGTTACCCTTGAGC^AGCGCAGGAAC.^CAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCT GGTCCAA 丁 CTCTACTATCAACCCGT'CTCCTCCGTCTAAAGAATCT'CATAAATCT'CCAAACATGGACTTTTAGCTTG GGAGAATGGAA^^CCCAGATGGAGGAGACC.^GGCACAGGACATTCTGGGAGCAGTGACCCTTCTGCTGGAGGGA GTGATGGCAGCACGGGGAC.^CTGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAGCTTTCTGGACAGGTCCGT CTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGCTTCCTCCACAGGGCAGGACCACAGCTCACPuVGGAT CCCA.VTGCCATCTTCCTGAGCTTCCAACACCTGCTCCGAGG.\A.^GGTGCGTTTCCTGATGCTTGTAGGAGGGTCC ACCCTCTGCGTCAGGGAATTCGGCGGC.^ACATGGCGTCTCCCGCTCCGCCTGCTTGTGACCTCCGAGTCCTCAGT AAACTGCTTCGTGACTCCCATGTCCTTCACAGCAGACTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCT GTCCTGCTGCCTGCTGTG SEQ ID MO:45

65 OM0M2351G

GCTA^CTGCTCTAT^.TGATCGATGAAATTATACATCACTTA.^GAGACCACCTGCACCTTTGCTGGACCCG；^C AJ\CCTC,'^TGACG^GACGTCTCTATCCTGATGGACCG^\ACCTTCGACTTCC^\.nCCTGGAGAGCTTCGTAAGG GCTGTC^G^CTTAGA.V^TGCATCAGGTATTGAGGCAATTCTTCGTAATCTCC；^ACCATGTCTGCCCTCTGCC 70 ACGQCCuCACCCTCTCGACATCC^.TCATCATC.^GGCAGGTGACTGGC^GA.ATTCCGGG^Aj\AACTGACGTTC T.ATCGGTTACCCTTGAGC.^AGCGCAGGA^.CAACAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGGAACCGTCTCG TCC^.TCTCTACTATC^\CCCGTCTCCTCCGTCT.\AAG^TCTCAT.\A^.CTCCAAACATGGGAGAATGGAAAACC CAGATGGAGGAGACC^GGCACAGGACATTCTGGAGCAGTGACCCTTCTGCTGGAGGGAGTGATGGCAGCACGGG GACAACTGGGACCCACTTGCTCTCATCCCTCCTGGGGCAGCTTTCTGGACAGGTCCGTCTCCTCCTTGGGGCCCT 75 GCAGGCCTC：TTGGAACCCAGCTTCCTCCACAGGGCAGGACCACAGCTCAC.\AGGATCCCAATGCATCTTCCTGA O:\92\92747.DOC -120- 200413407 GCTTCC.^CACCTGCTCCGAGGAAAGGTGCGTTTCCTGATGCTTGTAGGGGGTCCACCCTCTGCGTCAGGGAP.TT CGGCGGCAACATGGCGTCTCCCGCTCCGCCTGCTGTGACCTCCGAGTCCTCAGTAJ^aCTGCTTCGTGACTCCCAT GTCCTTCACAGCAGACTGACCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTCCTGCTGCCTGCTGTGGACT TTAGTTG SEQ ID NO:46 PMON28511 GCTA.\CTGCTCTATAATGATCGATGAA.^TTATACATCACTTA.^GAGACCACCTGCACCTTTGCTGGACCCG^C AACCTCAATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAGCTTCGTAAGG 10 GCTGTCAAGAACTTAGAAAATGCATCAGGT.VTTGAGGCAATTCTTCGTAATCTCCA^.CCATGTCTGCCCT'CTGCC ACGGCCGCACCCTCT'CGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCT GGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGGACCCACTTGC CTCTCATCCCTCCTGGGGCAGCTTTCTGGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGA.^CC 15 CAGCTTCCTCCACAGGGCAGGACCACAGCTCAC^GGATCCC^TGCCATCTTCCTGAGCTTCC.^CACCTGCTC CGAGGAAAGGTGCGTTTCCTGATGCTTGTAGGAGGGTCCACCCTCTGCGT'CAGGGAATTCGGCGGCAACATGGCG TCTCCCGCTCCGCCTGCTTGTGACCTCCGAGTCCTCAGTAAACTGCTTCGTGACTCCCATGTCCTTCACAGCAGA CTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTCCTGCTGCCTGCTGTGGACTTTAGCTTGGGAG^A TGGAAAACCCAGATGGAGGAGACCAAGGCACAGGACATTCTGGGAGCAGTGACCCTTCTGCTGGAGGGAGTGATC 20 GCAGCACGGGGACAACTG SEQ ID N〇：47 pMOM2S512 25 30 35 GCTAACTGCTCTATAATGATCGATG^ATTATACATCACTT^J\AGAGACCACCTGCACCTTTGCTGGACCCGA.VC AACCTCAATGACGAAGACGTCTCTATCCTGATGGACCG^^CCTTCGACTTCC^^CCTGGAGAGCTTCGT^GG GCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTA.\TCTCC^\CCATGTCTGCCCTCTGCC ACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCP^AGAATTCCGGGAAAA^*CTGACGTTC TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGG’CGGTGGAGGCTCCCCGGGTGAACCGTCT GGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGPu^TCTCAT.^^ATCTCCXAACATGGGAACCCAGCTT CCTCCACAGGGCAGGACCACAGCTCACAAGGATCCCAATGCCATCTTCCTGAGCTTCC.^CACCTGCTCCGAGGA AAGGTGCGTTTCCTGATGCTTGTAGGAGGGTCCACCCTCTGCGTCAGGGAATTCGGCGGC^\CATGGCGTCTCCC GCTCCGCCTGCTTGTGACCTCCGAGTCCTCAGTAAACTGCTTCGTGACTCCCATGTCCTTCACAGCAGACTGAGC CAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTCCTGCTGCCTGCTGTGGACTTTAGCTTGGGAGAATGGAP^ ACCCAGATGGAGGAGACCAAGGCACAGGACATTCTGGGAGCAGTGACCCTTCTGCTGGAGGGAGTGATGGCAGCA CGGGGAC*\ACTGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAGCTTTCTGGACAGGTCCGTCTCCTCCTTGGG GCCCTGCAGAGCCTCCTT SEQ ID MO:48

40 45 50 PMOM23513 GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTT^J^GAGACCACCTGCACCTTTGCTGGACCCGA^.C AACCTCAATGACGA.\GACGTCTCTATCCTGATGGACCG^AACCTTCGACTTCCAAACCTGGAGAGCTTCGTAAGG GCTGTCAAG^-ACTTAGAAA^.TGCATCAGGTATTGAGGCAATTCTTCGTAATCTCC^CCATGTCTGCCCTCTGCC ACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGA^.TTCCGGGAAAAACTGACGTTC TATCTGGTTACCCTTGAGC^GCGCAGGAACAACAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCT GGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATP^ATCTCCAAACATGGGCAGGACCACA GCTCAC^GGATCCCAATGCCATCTTCCTGAGCTTCCAACACCTGCTCCGAGG^AAGGTGCGTTTCCTGATGCTT GTAGGAGGGTCCACCCTCTGCGTCAGGGAATTCGGCGGCAACATGGCGTCTCCCGCTCCGCCTGCTTGTGACCTC CGAGTCCTCAGTAA^.CTGCTTCGTGACTCCCATGTCCTTCACAGCAGACTGAGCCAGTGCCCAGAGGTTCACCCT TTGCCTACACCTGTCCTGCTGCCTGCTGTGGACTTTAGCTTGGGAGAATGGAA^.ACCCAGATGGAGGAGACC；^G GCACAGGACATTCTGGGAGCAGTGACCi：TTCTGCTGGAGGGAGTGATGGCAGCACGGGGACA>.CTGGGACCCAC·? TGCCTCTCATCCCTCCTGGGGCAGCTTTCTGGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGA ACCCAGCTTCCTCCACAG SEQ ID MO: 49

DMON23514 GCT.V\CTGCTCTAT.\ATGATCGATGAA.^TTATACATCACTT.\.\A.GAGACCACCTGCACCTTTGCTGGACCCGPu^C AACCrrCAATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAGCTTCGTAAGG GCTGTCiJ\GA.ACTTAGAA^TGCATCAGGTATTGAGGC.^ATTCTTCGT^TCTCC^CCATGTCTGCCCTCTGCC ACGGCCGCACCCTCT'CGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGA^^AAACT'GACGTTC 60 TATCTGGTTACCCTTGAGC^GCGCAGG^CAACAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGA^.CCGTCT GGTCCAAT'CTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCPIAACATGGCTCACAAGGAT CCC.\ATGCCATCTTCCTGAGCTTCCAACACCTGCTCCGAGG.^AAGGTGCGTTTCCTGATGCTTGTAGGAGGGTCC ACCCTCTGCGTCAGGGAATTCGGCGGCAACATGGCGTCTCCCGCTCCGCCTGCTTGTGACCTCCGAGTCCTCAGT ^.ACTGCTTCGTGACTCCCATGTCCTTCACAGCAGACTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCT 65 GTCCTGCTGCCTGCTGTGGACTTTAGCTTGGGAGAATGGAAAACCCAGATGGAGGAGACC^AGGCAC.^GGACATT CTGGGAGCAGTGACCCTTCTGCTGGAGGGAGTGATGGCAGCACGGGGACA-^CTGGGACCCACTTGCCTCTCATCC CTCCTGGGGCAGCTTTCTGGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGCTTCCT CCACAGGGCAGGACCACA SEQ ID NO :50 70 CMOM23515

GCTAACTGCTCTAT.^ATGATCGATGAAATTATACATCACTT.\A.*\GAGACCACCTGCACCTTTGCTGGACCCGA^.C .^ACCTCA^TGACG^\GACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCA.\ACCrrGGAGAGCTTCGT.\.-\GG GCTGTCAAG^CTTAGAA-^ATGCATCAGGTATTGAGGCA.\TTCTTCGTAATCTCC^\CCATGTCTGCCCTCTGCC 75 ACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGC*\AGAATTCCGGGPu\AAACTGACGTTC 121 -

O:\92\92747.DOC 200413407 TATCTGGTTACCCTTGAGCAAGCGCAGGAAC.^ACAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTG^CCGTCT GGTCCAATCTCTACTATC.\ACCCCTCTCCTCCGTCTi\AAGAATCTCATAAATCTCCAA.<\CATGGATCCCAATGCC ATCTTCCTGAGCTTCCA^CACCTGCTCCGAGG*\AAGGTGCGTTTCCTGATGCTTGTAGGAGGGTCCACCCTCTGC GTCAGCGAATTCGGCGGCAACATGGCGTCTCCCGCTCCGCCTGCTTGTGACCTCCGAGTCCTCAGTAAACTGCTT 5 CGTGACTCCCATGTCCTTCACAGCAGACTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTCCTGCTG CCTGCTGTGGACTTTAGCTTGGGAGAATGGAA.\ACCCAGATGGAGGAGACC.\AGGCACAGGACATTCTGGGAGCA GTGACCCTTCTGCTGGAGGGAGTGATGGCAGCACGGGGAC^CTGGGACCCACTTGCCTCTCATCCCTCCTGGGG CAGCTTTCTGGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGCTTCCTCCACAGGGC AGGACCACAGCTCACAAG SEQ ID NO :51 10 PMON28516

GCT^CTGCTCTAT.\ATGATCGATGAAATTATACATCACTT.\\AGAGACCACCTGCACCTTTGCTGGACCCG^C A.^CCTCAATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAGCTTCGT.\AGG 15 GCTGTC.UG‘仏 CTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCATGTCTGCCCTCTGCC ACGGCCGCACCCTCTCGACATCC.WTCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC TATCTGGTTACCCTTGAGC^GCGCAGGAAC*\ACAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTG^CCGTCT GGTCCAATCTCTACT'ATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCATCTTCCTG AGCTTCC.^CACCTGCTCCGAGGAA.^GGTGCGTTTCCTGATGCTTGTAGGAGGGTCCACCCTCTGCGTCAGGGAA 20 TTCGGCGGCAACATGGCGTCTCCCGCTCCGCCTGCTTGTGACCTCCGAGTCCTCAGTAAACTGCTTCGTGACTCC CATGTCCTTCACAGCAGACTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTCCTGCTGCCTGCTGTG GACTTTAGCTTGGGAG^TGGA.^AACCCAGATGGAGGAGACC^GGCACAGGACATTCTGGGAGCAGTGACCCTT CTGCTGGAGGGAGTGATGGCAGCACGGGC-ACAACTGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAGCTTTCT GGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGCTTCCTCCACAGGGCAGGACCACA 25 GCTCACAAGGATCCCAAT SEQ ID MO:52 pMOM23519 ,

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTGCACCTTTGCTGGACCCG^.C 3〇 Pu^CCTCAATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCC^^ACCTGGAGAGCTTCGTAAGG GCTGTCA^*GAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCATGTCTGCCCTCTGCC ACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAG^TTCCGGGAAAA.i\CTGACGTTC TATCTGGTTACCCTTGAGCAAGCGCAGGAAC^CAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCT ， GGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATC丁CATAAATCTCCAAACATGGAGGTTCACCCT 35 TTGCCTACACCTGTCCTGCTGCCTGCTGTGGACTTTAGCTTGGGAGAATGGAAAACCCAGATGGAGGAGACC*\AG GCACAGGACATTCTGGGAGCAGTGACCCTTCTCCTGGAGGGAGTGATGGCAGCACGGGGACAACTGGGACCCACT TGCCTCTCATCCCTCCTGGGGCAGCTTTCTGGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGA ACCCAGCTTCCTCCACAGGGCAGGACCACAGCTCACPuAGGATCCCAATGCCATCTTCCTGAGCTTCCAACACCTG CTCCGAGGAA.^GGTGCGTTTCCTGATGCTTGTAGGAGGGTCCACCCTCTGCGTCAGGGAATTCGGCAACATGGCG 40 TCTCCCGCTCCGCCTC-CTTGTGACCTCCGAGTCCTCAGTAAACTGCTTCGTGPvCTCCCATGTCCTTCACAGCAGA CTGAC-CCAGTGCCCA SEQ ID NO :53 PMOM23520

45 GCT^CTGCTCTATA.\TGATCGATGAAATTATACATCACTTX^GAGACCACCTGCACCTTTGCTGGACCCGA.'*C

AACCTC.\ATGACGA^.GACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCC^^ACCTGGAGAGCTTCGTAAGG GCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCATGTCTGCCCTCTGCC ACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGA.\TTCCGGGAAAA.^CTGACGTTC ^ TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTG^ACCGTCT ：)0 GGTCC.-ATCTCTACTATC^CCCGTCTCCTCCGTCTAAAG^TCTCATAA.^TCTCCAP-^CATGTTGCCTACACCT GTCCTGCTGCCTGCTGTGGACTTTAGCTTGGGAGA.^TGGA.A^CCCAGATGGAGGAGACC-\AGGCACAGGACATT CTGGGAGCAGTGACCCTTCTGCTGGAGGGAGTGATGGCAGCACGGGGACAACTGGGACCCACTTGCCTCTCATCC CTCCTGGGGCAGCTTTCTGGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGG^\CCCAGCTTCCT _ _ CCACAGGGCAGGACCACAGCTCACA^.GGATCCC^TGCCATCTTCCTGAGCTTCC^CACCTGCTCCGAGGA^G 55 GTGCGTTTCCTGATGCTTGTAGGAGGGTCCACCCTCTGCGTCAGGGPvATTCGGC^.CATGGCGTCTCCCGCTCCG CCTGCTTGTGPxCCTCCGAGTCCTCAGTA.^CTGCTTCGTGACTCCCATGTCCTTCACAGCAGACTGr\GCCAGTGC CCAGAGGTTCACCCT SEQ ID NO:54 OMCN23521 60 ^

GCT.^.CTC,CTCTAT^TGATCGATGA.\ATTATACATCACTTAP«^GAGACCACCTGCACCTTTGCTGGACCCGAAC

AACCTCAATGACGAAGACGTCT'CTAT'CCTGATGGACOGAAACCTTCGACTTCCAAACCTGGAGAGCTTCGTAAGG GCTGTCAAGAACTTAG^^TGCATCAGGTATTGAGGC^\TTCTTCGTAATCTCC.V\CCATGTCTGCCCTCTGCr； ACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTr: 6：) tatctggttacccttgagc.^.gcgcagga.^caacagtacgtagagggcggtggaggctccccgggtgaaccgtct

GGTCC^TCTCTACTATC^CCCGTCTCCTCCGTCT.\A.^G*\ATCTCATAA^.TCTCC.-^CATGGTCCTGCTGCCT GCTGTGGACTTTAGCTTGGGAGA.^TGGAAAACCCAGATGGAGGAGACCP^AGGCACAGGACATTCTGGGAGCAGTC-ACCCTTCTGCTCGAGGGAGTGATGGCAGCACGGGGAC.\ACTGGGACCCACTTGCCTCTCATCCCTCCTCGGGCAG CTTTCTGGACAGGTCCGTCTCCTCCTTGGGGvCCCTGCAGAGCCTCCTTGGA.^CCCAGCTTCCTCCACAGGGCAGG 70 ?JCP£^S?：Cc^GGATCCC^^GCCATCTTCCTGAGC7TCC.-\ACACCTGCTCCCAGGA.*UGGTGCG,rTTCCTC AT^JT?I^5S'^?iST?CACCCTCTGCGTCAGGG^TTC^GCAACATGGCGTCTCCCGCTCCGCcTGCTTGTG^r-

iISC〇AGTCCTCAGTAA^*CTGCTTCGTGACTCCCATGTCCTT-ACAGCAGACTGAGCCAGTGCCCAGAGGTTCAC ^-CTTTGCCTACACCT SEQ ；〇 N〇；5S 75 PMOM2B522 122-

O:\92\92747.DOC 200413407

GCTAACTGCTCTATAATGATCGATGA.^TTATACATCACTTA.^GAGACCACCTGCACCTTTGCTGGACCCGAAC .AACCTC^\TGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCC^\ACCTGGAGAGCTTCGTAAGG GCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGC^TTCTTCGTAATCTCCAACCATGTCTGCCCTCTGCC 5 ACGGCCGCACCCTCTCGACATCCAATCATCATCAAGCCAGGTGACTGGCAAGAATTCCGGGAAAAACTCACGTTC

TATCTGGTTAgggTTQAGC^GCGCAGGMC^CAGTACGTAGAGGGCGGTGGAGGCTCCCCGCGTGAACCGTCT GGTCC.^ATCTCTACT'ATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCTGTGGACTTT AGCTT^GGAGAATGGAAAACCCAGATGGAGGAGACCAAGGCACAGGACATTCTGGGAGCAGTGACCCTTCTGCTG GAGGG^GTGATGGCAGCACGGGGACAACTGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAGCTTTCTGGACAG 10 GTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGCTTCCTCCACAGGGCAGGACCACAGCTCAC AAGGATCCCAATGCCATCTTCCTGAGCTTCC^CACCTGCTCCGAGGAAAGGTGCGTTTCCTGATGCTTGTAGGA GGGTCCACCCTCTGCGTCAGGGAATTCGGC^CATGGCGTCTCCCGCTCCGCCTGCTTGTGACCTCCGAGTCCTC AGT^AACTGCTTCGTGACTCCCATGTCCTTCACAGCAGACTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACA CCTGTCCTGCTGCCT SEQ ID MO :5 β 15 PMOM23523 GCT^CTGCTCTAT^TGATCGATGAAA.TTATACATCACTT.\AAGAGACCACCTGCACCTTTGCTGGACCCG^\C AACCTCAATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAGCTTCGTAAGG 20 GCTGTCAAG^CTTAGA.\AATGCATCAGGTATTGAGGCAATTCTTCGTA.\TCTCC^CCATGTCTGCCCTCTGCC ACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAG^TTCCGGGAAAAACTGACGTTC TATCTGGTTACCCTTGAGCA.\GCGCAGGAACAACAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGPu\CCGTCT GGTCC.\ATCTCTACTATCA^.CCCGTCTCCTCCGTCTAAAGAj\TCTCATAAATCTCC.\AACATGGACTTTAGCTTG GGAGAATGGAAAACCCAGATGGAGGAGACCAAGGCACAGGACATTCTGGGAGCAGTGACCCTTCTGCTGGAGGGA 25 GTGATGGCAGCACGGGGAC*\ACTGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAGCTTTCTGGACAGGTCCGT CTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGCTTCCTCCACAGGGCAGGACCACAGCTCACAAGGAT CCCAATGCCATCTTCCTGAGCTTCCAACACCTGCTCCGAGGAAAGGTGCGTTTCCTGATGCTTGTAGGAGGGTCC ACCCTCTGCGTCAGGGAATTCGGCAACATGGCGTCTCCCGCTCCGCCTGCTTGTGACCTCCGAGTCCTCAGTP·^ CTGCTTCGTGACTCCCATGTCCTTCACAGCAGACTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTC 30 CTGCTGCCTGCTGTG SEQ ID N〇：57 PMCN23524 GCTAACTGCTCTAT^TGATCGATGAAATTATACATCACTTAAAGAGACCACCTGCACCTTTGCTGGACCCG^C 35 AACCTCA.\TGACGA.\GACGTCTCTATCCTGATGGACCGP^ACCTTCGACTTCCAA.^CCTGGAGAGCTTCGTAAGG GCTGTCAAGAACTTAGAAA-\TGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCA^*CCATGTCTGCCCTCTGCC ACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCT GGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCA^^ACATGGGAGAATGGAAA 40 ACCCAGATGGAGGAGACCAAGGCACAGGACATTCTGGGAGCAGTGACCCTTCTGCTGGAGGGAGTGATGGCAGCA CGGGGACAACTGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAGCTTTCTGGACAGGTCCGTCTCCTCCTTGGG GCCCTGCAGAGCCTCCTTGG^CCCAGCTTCCTCCACAGGGCAGGACCACAGCTCACAAGC-ATCCCAATGCCATC TTCCTGAGCTTCCAACACCTGCTCCGAGGA^AGGTGCGTTTCCTGATGCTTGTAGGAGGGTCCACCCTCTGCGTC _ AGGG^TTCGGCAACATGGCGTCTCCCGCTCCGCCTGCTTGTGACCTCCGAGTCCTCAGT^JVACTGCTTCGTGAC 45 TCCCATGTCCTTCACAGCAGACTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTCCTGCTGCCTGCT GTGGACTTTAGCTTG SEQ ID NO:53 ?MON23525 λ 50 gctaactgctcta^taatgp/tcgatgaaattatacatcacttaaagagaccacctgcacctttgctggacccgaac

AACCTC^TGACG^GACGTCTCTATCCTGATGGACCGA.\ACCTTCGACTTCCAAACCTGGAGAGCTTCGT^.GG GCTGTCA.\G^CTTAGAA.^TGCATCAGGTATTGAGGC^TTCTTCGTAATCTCCA^.CCATGTCTGCCCTCTGCC ACGGCCGCACCCTCTCGACATCCA^ATCATCATC^.GGCAGGTGACTGGCAAGAATTCCGGGAP^^CTGACGTTC TATCTGGTTACCCTTGAGC-^AGCGCAGGAAC^-ACAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTG^CCGTCT 55 GGTCCP.^TCTCTPvCTATC.^ACCCGTCTCCTCCGTCT.\.\AGAt^TCTCAT.\AATCTCC?u^vCATGGGACCCACTTGC CTCTCATCCCTCCTGGGGC.^GCTTTCTGGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGG^CC CAGCTTCCTCCACAGGGCAGGACCACAGCTCACA.\GGATCCC^.TGCCATCTTCCTGAGCTTCCAACACCTGCTC CGAGGA.\AGGTGCGTTTCCTGATGCTTGTAGGAGGGTCCACCCTCTGCGTCAGGGAATTCGGCAACATGGCGTCT CCCGCTCCGCCTGCTTGTGACCTCCGAGTCCTCAGTAAACTGCTTCGTGACTCCCATGTCCTTCACAGCAGACTG 60 AGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTCCTGCTGCCTGCTGTGGACTTTAGCTTGGGAGAATGG A^AACCCAGATGGAGGAGACC^GGCACAGGACATTCTGGGAGCAGTGACCCTTCTGCTGGAGGGAGTGATGGC：A GCACGGGGAC.\ACTG SEQ ID NO:S9 PMOM23525 65

GCT^\CTGCTCTATAATCATCGATG^^TTATACATCACTT；^GAGACCACCTGCACCTTTGCTGGACCCGAAC AACCTCAATGACGAAGACGTCTCT.VTCCTC'ATGGACCGAAACCTTCGACTTCCAAACCTGGAGAGCTTCGTAAGG GCTGTC^\G^CTTAGAA.^A7GCATCAGGTATTGAGGC^TTCTTCGTA.\TCTCC；-vACCATGTCTGCCCTCTGCC ACGGCCGCACCCTCTCGACATCCAATCATCATC^GGCAGGTGACTGGC.\AGP>.ATTCCGGGA.\^^CTGACGTTC 70 TATCTCCTT；，CCCTTGAGC.V*.GCGCAGGAAC^\CAGTACGTAGAGGGCGGTGvGAGGCTCCCCGGGTG^CCGTCT GGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCT'CCAAACATGGGAACCCAGCTT CCTCCAC,\GGGCAGGACCACAGCTCACAAGGATCCC.^ATGCCATCTTCCTGAGCTTCCAi\CACCTGCTCCGAGGA .^AGGTCCGTTTCCTGATGCTTGTAGGAGGGTCCACCCTCTGCGTCAGGGAATTCGGC^CATGGCGTCTCCCCCT CCGCCTGCTTGTGACCTCCGAGTCCTCAGTAAACTGCTTCGTGACTCCCATGTCCTTCACAGCAGACTGAGCCAG 75 TGCCCAOAGGTTCACCCTTTGCCTACACCTGTCT：TGCTGCCTGCTGTGGACTTTAGCTTGCGAG/VaTGG；vAA.^CC -123 -

O:\92\92747.DOC 200413407 CAGATGGAGGAGACC.\AGGCACAGGACATTCTGGGAGCAGTGACCCTTCTGCTGGAGGGAGTGATGGCAGCACGG CGAC^CTGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAGCTTTCTGGACAGGTCCGTCTCCTCCTTGGGGCC CTGCAGAGCCTCCTT S£Q ID NO：60 DMON23527

GCT^CTGCTCTATAATGATCGATG^ATTATACATCACTT^^GAGACCACCTGCACCTTTGCTGGACCCG^C AACCTCAATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAGCTTCGTAAGG GCTGTC.\.AGiACTTAG.^AAATGCATCAGGTATTGAGGC.\ATTCTTCGTAATCTCC^CCATGTCTGCCCTCTGCC 10 ACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC TATCTGGTTACCCTTGAGCA.^GCGCAGGAACAACAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGA.\CCGTCT GGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCT.\AAGAATCTCATAAATCTCC>A.i\CATGGGCAGGACCACA GCTCACAAGGATCCC=.J\TGCCATCTTCCTGAGCTTCC\ACACCTGCTCCGAGGAAAGGTGCGTTTCCTGATGCTT _ gtaggagggtccaccctctgcgtcagggaattcggc^catggcgtctcccgctccgcctgcttgtgacctccga 15 GTCCTCAGT^^CTGCTTCGTGACTCCCATGTCCTTCACAGCAGACTGAGCCAGTGCCCAGAGGTTCACCCTTTG CCTACACCTGTCCTGCTGCCTGCTCTGGACTTTAGCTTGGGAGAATGGAAAACCCAGATGGAGGAGACCAAGGCA CAGGACATTCTGGGAGCAGTGACCCTTCTGCTGGAGGGAGTGATGGCAGCACGGGGAC^CTGGGACCCACTTGC CTCTCATCCCTCCTGGGGCAGCTTTCTGGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGG.V-vCC CAGCTTCCTCCACAG SEQ ID NO :61 20 PMOM23523 25 30 35 GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTGCACCTTTGCTGGACCCGAAC AACCTCAATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAGCTTCGTAAGG GCTGTCAAGA.^CTTAGAAAATGCATCAGGTATTGAGGC*\ATTCTTCGTAATCTCC.\ACCATGTCTGCCCTCTGCC ACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC TATCTGGTTACCCTTGAGC.:\AGGGCAGGA.-.CAACAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCT GGTCC.-J\TCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAA.\CATGGCTCAC*\AGGAT CCCAATGCCATCTTCCTGAGCTTCCAACACCTGCTCCGAGGAA.\GGTGCGTTTCCTGATGCTTGTAGGAGGGTCC ACCCTCTGCGTCAGGGAATTCGGCAACATGGCGTCTCCCGCTCCGCCTGCTTGTGACCTCCGAGTCCTCAGTAAA CTGCTTCGTGACTCCCATGTCCTTCACAGCAGACTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTC CTGCTGCCTGCTGTGGACTTTAGCTTGGGAGA-^TGGAAAACCCAGATGGAGGAGACC^-AGGCACAGGACATTCTG GGAGCAGTGACCCTTCTGCTGGAGGGAGTGATGGGAGCACGGGGACAACTGGGACCCACTTGCCTCTCATCCCTC CTGGGGCAGCTTTCTGGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGCTTCCTCCA CAGGGCAGGACCACA SEQ ID NO：62

40 45 50 55 60 65 pMOM28529 GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTGCACCTTTGCTGGACCCGAAC ^J\CCTC^ATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAGCTTCGTAAGG GCTGTCAJ\GAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTA^.TCTCCA^.CCATGTCTGCCCTCTGCC ACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAG.^TTCCGGGAA^AACTGACGTTC TATCTGGTTACCCTTGAGCAAGCGCAGG^CAACAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCT GGTCCP>ATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCA^^CATGGATCCCAATGCC ATCTTCCTGAGCTTCC.\ACACCTGCTCCGAGGP>-AAGGTGCGTTTCCTGATGCTTGTAGGAGGGTCCACCCTCTGC GTCAGGG.^TTCGGCAACATGGCGTCTCCCGCTCCGCCTGCTTGTGACCTCCGAGTCCTCAGTAAACTGCTTCGT GACTCCCATGTCCTTCACAGCAGACTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTCCTGCTGCCT GCTGTGGACTTTAGCTTGGGAG.^ATGGAA*^CCCAGATGGAGGAGACCAAGGCACAGGACATTCTGGGAGCAGTG ACCCTTCTGCTGGAGGGAGTGATGGCAOCACGGGGAC^CTGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAG CTTTCTGGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGCTTCCTCCACAGGGCAGG ACCACAGCTCAC^G SEQ ID NO： 63 PMOM23520 GCT'AACTGCTCTATAATGAT'CGATGAAATTATACATCACTTAAAGAGACCACCTGCACCTTTGCTGGACCCGAAC P.^CCTC.^TGACG^.GACGTCTCTATCCTGATGGACCG.\A^.CCTTCGACTTCCAAACCTGGAGAGCTTCGT^GG GCTGTCA^-GAACT'TAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCATGTCT'GCCCTCTGCC ACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC TATCTGGTTACCCTTGAGCAAGCGCAGG^C.^CAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTG^CCGTCT GGTCCAATCTCT'ACTArTCAACCCGTCr：CCrrCCGTCTAAAGAATCT'CATAAATCTCCAAACATGGCCATCTTCCTG AGCTTCCP^CACCTGCTCCGAGGAAAGGTGCGTTTCCTGATGCTTGTAGGAGGGTCCACCCTCTGCGTCAGGGAA TTCGGC.^CATGGCGTCTCCCGCTCCGCCTGCTTGTGACCTCCGAGTCCTCAGTA.^ACTGCTTCGTGACTCCCAT GTCCTTCACAGCAGACTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTCCTGCTGCCTGCTGTGGAC TTTAGCTTGGGAGAATGGAAP>^CCCAGATGGAGGAGACC.\AGGCACAGGACATTCTGGGAGCAGTGACCCTTCTG (：TGGAGGGAGTGATGGCAGCACGGGGAC^CTGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAGCTTTCTGGA CAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGG^CCCAGCTTCCTCCACAGGGCAGGACCACAGCT lACAACjGATCCCAAT SEQ 13 NO :64

GMOM23S3 ^ 70

GCT^\CTGCTCTATAATGATCGATGA/\ATTATACATCACTT；-u^GAGACCACCTGCACCTTTGCTGGACCCGPvAC ^CCTC.'v.ATGACG.^AGACGTCTCTATCCTGATGGACCG；u\ACCTTGACTTCC\-^CCTGGAGAGCTTCGTAAGGn CTGTC^G.^CTTAG.^'^TGCATCAGGTATGAGGC.^TTCTTCGT^TCTCC.'^ACCATGTCTGCCCTCTGCCAC GGCCGCACC1'TCTCGCATCC^\TCATCATC^AGGCAGGTGACTGGCA.-\GAATTCCGGGAAAAACTGACGTTCTAT 75 TGGTTACCCTTGAGCA.AGCGCAGGAACPu\CAGTACGTAGAGGGCCGTGGAGGCTCCCCGGT^CCGTCTGGTCCA -124-

O:\92\92747.DOC ATCTCTACTATCAACCCGTCTCCTCCGTCT.\AAGAATCTCAT.\AATCTCC^^ACATGGAGGTTCACCCTTTGCCT ACACCTGTCCTGCTGCCTGCTGTGGACTTTAGCTTGGGAGAATGGAAAACCCAGATGGAGGAGACCA.\GGCACAG GACATTCTGGGAGCAGTGACCCTTCTGCTGGAGGGAGTGATGGCAGCACGGGGACAACTGGGACCCACTTGCCTC TCATCCCTCCTGGGGCAGCTTTCTGGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAG 5 CTTCCTCCACAGGGCAGGACCACAGCTC?aCAAGGATCCCAATGCCATCTTCCTGAGCTTCC^CACCTGCTCCGA GGAAAGGTCCGTITCCTGATGCTTGTAGGAGGGTCCACCCTCTGCGTCAGGGAATTCGGCGGCAACGGCGGCAAC ATGGCGTCCCCAGCGCCGCCTGCTTGTGACCTCCGAGTCCTCAGTAA.^CTGCTTCGTGACTCCCATGTCCTTCAC AGCAGACTGAGCCAGTGCCCA SEQ ID MO :65 10 PMON28534 GCTAACTGCTCTAT*\ATGATCGATGAAATTATACATCACTT^hGAGACCACCTGCACCTTTGCTGGACCCGPvAC AACCTCAATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAGCTTCGTAAGG GCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCATGTCTGCCCTCTGCC 15 ACGGCCGCACCCTCTCGACATCCAATCATCATC.^AGGCAGGTGACTGGC.^AGAATTCCGGGP-^AAACTGACGTTC TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCT GGTCCAATCTCTACTATC^.CCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCA.\ACATGTTGCCTACACCT GTCCTGCTGCCTGCTGTGGACTTTAGCTTGGGAGAATGGAAi^ACCCAGATGGAGGAGACCAAGGCACAGGACATT CTGGGAGCAGTGACCCTTCTGCTGGAGGGAGTGATGGCAGCACGGGGACAACTGGGACCCACTTGCCTCTCATCC 20 CTCCTGGGGCA.GCTTTCTGGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGCTTCCT CCACAGGGCAGGACCACAGCTCAC^GGATCCCAATGCCATCTTCCTGAGCTTCCAACACCTGCTCCGAGGA^AG GTGCGTTTCCTGATGCTTGTAGGAGGGTCCACCCTCTGCGTCAGGGA^.TTCGGCGGCAACGGCGGCAACATGGCG TCCCCAGCGCCGCCTGCTTGTGACCTCCGAGTCCTCAGTAA*\CTGCTTCGTGACTCCCATGTCCTTCACAGCAGA CTGAGCCAGTGCCCAGAGGTTCACCCT SEQ ID NO :66 25 PMON23535 GCTAACTGCTCTATAATGATCGATG^AATTATACATCACTT^\AGAGACCACCTGCACCTTTGCTGGACCCG^C AACCTC^TGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCC^^ACCTGGAGAGCTTCGTAAGG 30 GCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTA^.TCTCCAACCATGTCTGCCCTCTGCC ACGGCCGCACCCTCTCGACATCCAATCATCATCA^.GGCAGGTGACTGGC^*AGAATTCCGGGAAAA.^CTGACGTTC TATCTGGTTACCCTTGAGCAAGCGCAGGAACAP-.CAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTG^CCGTCT GGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTA.\AGAATCTCATAAATCTCCAAACATGC-TCCTGCTGCCT GCTGTGGACTTTAGCTTGGGAGAATGGAAAACCCAGATGGAGGAGACCAAGGCACAGGACATTCTGGGAGCAGTG 35 ACCCTTCTGCTGGAGGGAGTGATGGCAGCACGGGGACAACTGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAG CTTTCTGGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGCTTCCTCCACAGGGCAGG ACCACAGCTCACAAGGATCCCAATGCCATCTTCCTGAGCTTCCAACACCTGCTCCGAGGA^AGGTGCGTTTCCTG ATGCTTGTAGGAGGGTCCACCCTCTGCGTCAGGGAATTCGGCGGCAACGGCGGCAACATGGCGTCCCCAGCGCCG CCTGCTTGTGACCTCCGAGTCCTCAGT.^A^.CTGCTTCGTGACTCCCATGTCCTTCACAGCAGACTGAGCCAGTGC 40 CCAGAGGTTCACCCTTTGCCTACACCT SEQ ID MO : 6 7 pMON2 8 5 3 6 GCTA.\CTGCTCTAT.\ATGATCGATG.\AATTATACATCACTT^^GAGACCACCTGCACCTTTGCTGGACCCG^\C 45 ^.CCTC^TGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAGCTTCGT.VsGG GCTGTC^\GAACTTAG^^AATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCA-aCCATGTCTGCCCTCTGCC A.CGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC TATCTGGTTACCCTTGAGC.^GCGCAGGAACAACAGTACGTAGAGGGCGGTGGAGGCTCCCCC-GGTG.\ACCGTCT GGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCT'CATAAATCTCCAAACATGGCTGTGGACTT.T 50 AGCTTGGGAGA.VrGGAAA^CCCAGATGGAGGAGACC.^GGCACAGGACATTCTGGGAGCAGTGACCCTTCTGCTG GAGGGAGTGATGGCAGCACGGGGAC^CTGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAGCTTTCTGGACAC； GTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGG^CCCAGCTTCCTCCACAGGGCAGGACCACAGCTCAC AAGGATCCCP>^TGCCATCTTCCTGAGCTTCCA.^CACCTGCTCCGAGG.\AAGGTGCGTTTCCTGATGCTTGTAGGA GGGTCCACCCTCTGCGTCAGGGAATTCGGCGGC^CGGCGGCA.^CATGGCGTCCCCAGCGCCGCCTGCTTGTGAC 55 CTCCGAGTCCTCAGTA.\ACTOCTTCGTGACTCCCATGTCCTTCACAGCAGACTGAGCCAGTGCCCAGAGGTTCAC CCTTTGCCTACACCTGTCCTGCTGCCT SEQ ID MO: 63 pMOM28537

60 GCT.^\CTGCTCTAT.\ATGATCGATG^\TTATACATCACTT.^\AGAGACCACCTGCACCTTTGCTGGACCCGA^C AACCTCPJVTGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGPvGAGCTTCGTAAGG GCTGTC.\AG^CTTAGAA^^TGCATCAGGTATTGAGGCAATTCTTCGT.\ATCTCC^\CCATGTCTGCCCTCTGCC ACGGCCGCACCCTCTCGACATCC.\ATCATCATC^GGCAGGTGACTGGC^GAATTCCGGGA.^\ACTGACGTTC TATCTGGTTACCCTTGAGC*\AGCGCAGGAACAACAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTG；-uhCCGTCT 65 GGTCC；\ATCTCTACTATCAACCCGTCTCCTCCGTCTA.\AG^TCTCATAAATCTCC.^ACATGGACTTTAGCTTC GGAG*\ATGGAJ^^CCCAGATGGAGGAGACC^GGCACAGGACATTCTGGGAGCAGTGACCCTTCTGCTGGAGGGA gtgatggcagcacggggac.^ctgggacccacttgcctctcatccctcctggggcagctttctggacaggtccgt CTCCTCCT-rGGGGCCCTGCAGAGCCTCCTTGG.^CCCAGCTTCCTCCACAGGGCAGGACCACAGCTCACA^.GGAT CCCA^TGCCATvCTTCCTGAGCTTCC.^CACCTGCTCCGAGGAA.^GGTGCGTTTCCTGATGCTTGTAGGAGGGTCC 70 ACCCTCTGCGTCAGGG^TTCGGCGGCA^CGGCGGCAACATGGCGTCCCCAGCGCCGCCTGCTTGTGACCTCCGA GTCCTCAOTAA.^CTGCTTCGTGACTCCCATGTCCTTCACAGCAGACTGAGCCAG,rGCCCAGAGGTTCACCCTTTG CCTACACCTGTCCTGCTGCCTGCTGTG SEQ ID MO :69 〇MON2 B 5 3 3 75 ^

O:\92\92747.DOC -125 - 200413407 GCTAACTGCTCTATAJ\TGATCGATGAA.\TTATACATCACTT,V\A.GAGACCACCTGCACCTTTGCTGGr\CCCGA.\C AACCTCAATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAGCTTCGTAAGG GC 丁 GTCAAGAACTTAGAAAATGCATCAGGTiVTTGAGGCAATTCTTCGTAATCTCCAACCATGTCTGCCCTCTGCC 一 ACGGCCGCACCCTCTCGACATCC.^ATCATCATCAAGGCAGGTGACTGGCA.\G.^ATTCCGGG^-AA.^CTGACGTTC 5 TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCT GGTCCA,\TCTCTACTATCAACCCGTCTCCTCCGTCT.\AAGAATCTCAT*\AATCTCCAi\ACATGGGAGAATGG^lAA ACCCAGATGGAGGAGACC^GGCACAGGACATTCTGGGAGCAGTGACCCTTCTGCTGGAGGGAGTGATGGCAGCA CGGGGAC.^ACTGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAGCTTTCTGGACAGGTCCGTCTCCTCCTTGGG GCCCTGCAGAGCCTCCTTGGA.\CCCAGCTTCCTCCACAGGGCAGGACCACAGCTCACAAGGATCCCAATGCCATC 10 TTCCTGAGCTTCCAACACCTGCTCCGAGGAAAGGTGCGTTTCCTGATGCTTGTAGGAGGGTCCACCCTCTGCGTC AGGGAATTCGGCGGC^CGGCGGCAACATGGCGTCCCCAGCGCCGCCTGCTTGTGACCTCCGAGTCCTCAGTAAA CTGCTTCGTGACTCCCATGTCCTTCACAGCAGACTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTC CTGCTGCCTGCTGTGGACTTTAGCTTG SEQ ID MO :70 15 CMOM2 S 5 3 9

GCT^ACTGCTCTATA.^TGATCGATGAAATTATACATCACTT.\AAGAGACCACCTGCACCTTTGCTGGACCCG^C

AACCTC^TGACG^GACGTCTCTATCCTGATGGACCG^AACCTTCGACTTCC.^AACCTGGAGAGCTTCGTAAGG

GCTGTC^GA^*CTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGT.\ATCTCC^CCATGTCTGCCCTCTGCC 20 acggccgcaccctctcgacatccaatcatcatcaaggcaggtgactggcaagaattccgggaaaaactgacgttc

.TATTCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGGTGGAGGCT'CCCCGGGTGAACCGTCT GGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACA丁GGGACCCACTTGC CTCTCATCCCTCCTGGGGCAGCTTTCTGGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGAACC 一 CAGCTTCCTCCACAGGGCAGGACCACAGCTCACAAGGATCCCAATGCCATCTTCCTGAGCTTCCAACACCTGCTC 25 CGAGGAAAGGTGCGTTTCCTGATGCTTGTAGGAGGGTCCACCCTCTGCGTCAGGGAATTCGGCGGCAACGGCGGC AACATGGCGTCCCCAGCGCCGCCTGCTTGTGACCTCCGAGTCCTCAGT.^JiACTGCTTCGTGACTCCCATGTCCTT CACAGCAGACTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTCCTGCTGCCTGCTGTGGACTTTAGC TTGGGAGP-ATGG^^AACCCAGATGGAGGAGACCAAGGCACAGGACATTCTGGGAGCAGTGACCCTTCTGCTGGAG GGAGTGATGGCAGCACGGGGACAACTG SEQ ID Μ〇··71 30 PMCN23540 GCTAACTGCTCTATAATGATCGATGAJ\ATTATACATCACTTA.A^.GAGACCACCTGCACCTTTGCTGGACCCG»^vC ^CCTC^TGACGAAGACGTCTCTATCCTGATGGACCG^J\CCTTCGACTTCCA.\.nCCTGGAGAGCTTCGTAAGG :5 GCTGTC.\AGAACTTAG.W-ATGCATCAGGTATTGAGGC.\ATTCTTCGT^J\TCTCCAACCATGTCTGCCCTCTGCC ACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGC^G.\ATTCCGGGAAAAACTGACGTTC TATCTGGTTACCCTTGAGCA.\GCGCAGGP-u\CPu\CAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCT GGTCC^TCTCTACTATC.^.CCCGTCTCCTCCGTCTA^AGAATCTCATAA.ATCTCC^AACATGGGAACCCAGCTT CCTCCACAGGGCAGGACCACAGCTCACAAGGATCCCAATGCCATCTTCCTGAGCTTCCAACACCTGCTCCGAGGA 40 AAGGTGCGTTTCCTGATGCTTGTAGGAGGGTCCACCCTCTGCGTCAGGGAATTCGGCGGCAACGGCGGC^-ACATG GCGTCCCCAGCGCCGCCTGCTTGTGACCTCCGAGTCCTCAGTAAACTGCTTCGTGACTCCCATGTCCTTCACAGC AGACTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTCCTGCTGCCTGCTGTGGACTTTAGCTTGGGA GAATGGAAAACCCAGATGGAGGAGACC^aGGCACAGGACATTCTGGGAGCAGTGACCCTTCTGCTGGAGGGAGTG ATGGCAGCACGGGGAC^CTGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAGCTTTCTGGACAGGTCCGTCTC 45 CTCCTTGGGGCCCTGCAGAGCCTCCTT SEQ ID NO :72 PMCM23541

^^*ACTGCTCTAT.-J\TGATCGATG.\^TTATACATCACTT.^^GAGACCACCTGCACCTTTGCTGGACCCGAAC

^^CTC^iYACG^GACGTCTC^TCCTGATGGACCGA.^CCTTCGACTTCCA-^.CCTGGAGAGCTTCGT^GG ^Ei5tS*^g*^cttag^^tgcatcaggtattgaggc*^ttcttcgt^tctcc'1^ccatgt-tgccctctgcc

ACGGCC3CACCCTCTCGACATCC^\TCATCATC^.GGCAGGTGACTGGCAAGA.\TTCCGGGAA.^-ACTGACGTTC

TATCTGGTTACCCTTGAGCA^.GCGCAGGAi.C.^ACAGTACGTAGAGGGCGGTGGPvGGCTCCCCGGGTGA.\CCGTCT 一 G5ii5^?TcI^IACTATC^CCCGTCTCCTCCGTCT^^G*^TCTCAT^',*TCTCC^^CATGGGCAGGACCACA )) ^HTSa^^5gatc^c*1^tgccatcttcctgagcttcca^cacctgctccgagg^^gg，tgcgttt--tgatgct'*：：' ^Ti：GGAGGGTCCACCCTCTGCGTCAGGG^TrrcGGCGGCA^.CGGCGGC.\ACATGGCGTCCCCAGCGCCGCCTGCT TGTGACCTCCGAGTCCTCAGTAA^^CTGCTTCGTGACTCCCATGTCCTTCACAGCAGACTGAGCCAGTGCCCAGAG GTTCACCCTTTGCCTACACCTGTCCTGCTGCCTGCTGTGGACTTTAGCTTGGGAGA^.TGGA^^CCCAGATGGAG ^?A^X*^GGCACAGGACATTCTGGGAGCAGTGACCCTTCTGCTGGAGGGAGTGATGGCAGCACGGGGAC.\ACTG 0U G^^CCCACTTGCCTCTCATCCCTCCTGGGGCAGCTTTCTGGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGC CiCCTTGG.^CCCAGCTTCCTCCACAG SEQ ID MO：73 PMON23542 65 70 75 "^'^CJGCTCTAT^TCATCGArrGAA^*TTA^ACATCACTTA^GAGACCACCTGCACCTTTGCTGGACCCGAAC ^^IS^tgacg^gacgtctctatcctgatggaccg^^ccttcgacttcc-:^cctggaga^cttcgtajvgg V^I^IC^GACTTAG^UTGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCATGTCTGCCCTCT'GCC ；^LSG2^'Si：?^EIETCrJACATCC*^TCATCATC^GGCAGGTGACTGGC-^-G^TTCCGGG^^-;^CTGACGTTC rATCTGGTTACCCTTGAGC^GCGCAGG^C.^CAGT.ACGTAGAGGGCGGTGGAGGCTCCCCGGGTG.^ACCGTCT ：，Sr：：^ZCTCT^CT；'TC*V'CCCGTCTCCTCCGTCT^G^TCT-^^TCTCC*^CATGGCTCAC^GGAT\7'X^J5：：I*y£!HT^STG^STTCC^CACCTCCTCCGAGG^GGTGCGTTTCCTGATGCTTGTAGGAGGGTCC ：^^：：^'°gcggc^cggcggc^catggcgtccccagcgccgcctgcttgtgacctccga ；：；；-；：*；-i^X-^：^；^CT^-^^GTCCTTCACAGCAGACTGAGCCAGTGCCCAGAGGTTCACCCTTTG ^GC^r：--"^^^'"rAV，；：^CTGTGGACTTTAGCTTGGGAG^TGGA^CCCAGATGG^GAGACC.^GGvCA ^^ccttctgctggagggagtgatggcagcacggggacaactgggacc^act-g^ -126-

O:\92\92747.DOC 200413407 CTCTCATCCCTCCTGGGGCAGCTTTCTGGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGG^CC CAGCTTCCTCCACAGGGCAGGACCACA SEQ ID NO: 74 CMCN23 54.3 5 ‘ ' GCTAACTGC 丁 CTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTGCACCTTTGCTGGACCCGAAC A-ACCTC^TGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCAj\ACCTGGAGAGCTTCGT^GG GC了GTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCATGTCTGCCCTCTGCC ACGGCCGCACCCTCTCGACATCC^TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAA.AAACTGACGTTC 10 TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCT GGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGATCCCAATGCC ATCTTCCTGAGCTTCCAACACCTGCTCCGAGGAAAGGTGCGTTTCCTGATGCTTGTAGGAGGGTCCACCCTCTGC GTCAGGGAATTCGGCGGC^CGGCGGC.^ACATGGCGTCCCCAGCGCCGCCTGCTTGTGACCTCCGAGTCCTCAGT AAACTGCTTCGTGACTCCCATGTCCTTCACAGCAGACTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCT 15 GTCCTGCTGCCTGCTGTGGACTTTAGCTTGGGAGAATGGAAAACCCAGATGGAGGAGACC^GGCACAGGACATT CTGGGAGCAGTGACCCTTCTGCTGGAGGGAGTGATGGCAGCACGGGGAC.\ACTGGGACCCACTTGCCTCTCATCC CTCCTGGGGCAGCTTTCTGGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGG^CCCAGCTTCCT CCACAGGGCAGGACCACAGCTCACP>AG SZQ ID NO : 7 5 20 OMGN23544 25 30 35 40 45 50 GCT^CTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTGCACCTTTGCTGvGACCCG^C AACiCTCAATGACGAAGACGTCTCTATCCTGATCGACCGAAACCTTCGACTTCCAAACCTGGAGAGCTTCGTAAGG GCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGT；^TCTCCA.^CCATGTCTGCCCTCTGCC ACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTG^CCGTCT GGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAA^.GAATCTCAT.\AATCTCCAAACATGGCCATCTTCCTG AGCTTCC^.CACCTGCTCCGAGGAAAGGTGCGTTTCCTGATGCTTGTAG'GAGGGTCCACCCTCTGCGTCAGGGAA TTCGGCGGCA^.CGGCGGCAACATGGCGTCCCCAGCGCCGCCTGCTTGTGACCTCCGAGTCCTCAGT^^CTGCTT CGTGACTCCCATGTCCTTCACAGCAGACTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTCCTGCTG CCTGCTGTGGACTTTAGCTTGGGAG.^ATGGAAA-ACCCAGATGGAGGAGACC.\AGGCACAGGACATTCTGGGAGCA GTGACCCTTCTGCTGGAGGGAGTGATGGCAGCACGGGGAC.\ACTGGGACCCACTTGCCTCTCATCCCTCCTGGGG CAGCTTTCTGGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGCTTCCTCCACAGGGC AGGACCACAGCTCACAAGGATCCCAAT SEQ ID NO : 7 6 PMON23545 GCT^J\CTGCTCTAT^TGATCGA'TGAAATTATACATCACTT.aAAGAGACCACCTGCACCTTTCCTGGACCCGAAC AACCTCA.nTGACGPu^GACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCAA*ACCTGGAGAGCTTCGTA^.GG GCTGTCAAGP.-ACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCC*\ACCATGTCTGCCCTCTGCC ACGGCCGCACCCTCTCGACATCCAATCATCATCA^.GGCAGGTGACTGGCP>J\GAATTCCGGGAAAP--ACTGACGTTC TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCT GGTCCA^TCTCTACTATCA.\CCCGTCTCCTCCGTCTAAAGA.\TCTCATAAATCTCC^\ACATGGATCCC.\ATGCC ATCTTCCTGAGCTTCC^CACCTGCTCCGAGGA^^.GGTGCGTTTCCTGATGCTTGTAGGAGGGTCCACCCTCTGC； GTCAGGG^TTCGGCGGC^CATGGCGTCTCCCGCTCCGCCTGCTTGTGACCTCCGAGTCCTCAGT^J^ACTGCTT CGTCtACTCCCATGTCCTTCACAGCAGACTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTCCTGCTG CCTGCTGTGGACTTTAGCTTGGGAGAATGGAA*\ACCCAGATGGAGGAGACC.-^GGCACAGGACATTCTGGGAGCA GTGACCCTTCTGCTGGAGGGAGTGATGGCAGCACGGGGAC^.CTGGGACCCACTTGCCTCTCATCCCTCCTGGGG CAGCTTTCTGGACAGGTCCGTCTCCTCCTTGGGGCCCTGCAGAGCCTCCTTGG^CCCAGGGCAGGACCACAGCT CACAAG SEQ ID MO :77 、 PMOMI5981 :-I 1 1 1 1 Λ-ΓΙ 1 1 1 1- 1- 1 I L L L o 5 o 5 o 5 o 5 o 5 o 5 o 5 o 5 o s i-1 2 2 3 3 4 4 5 5 ,o 6 ’.，【，3 CC 9 5560657075

A.TGGCTAACT GCTCTATAAT GP'TCGATGAA ATTATAC.VTC ACTTAAAGAG ACCACCTGCA CCTTTGCTGG ACCCG.^AC^ CCTC.\ATGAC G^GACGTCT CTATCCTGAT GGATCGAA^.C CTTCGACTTC CA.\.-\CCTGGA GAGCTTCGTA AGGGCTGTCA AGAACTTAGA .^\TGCATCA GGTATTGAGG C.V..TTCTTCG T.^TCTCC.V\ CCATGTCTGC CCTCTGCCAC GGCCGCACCC TCTCGACATC C人二‘TCATCAT CAAGGCPvGGT GACTGGCAAG AATTCCGGGA AAAACTGACG TTCTATCTGG TTACCCTTGA GCA-^GCGCAG O^.CAACAGT ACGTAGAGGG CGGTGGAGGC TCCCCGGGTG AACCGTCTGG TCC.^TCTCT ACTATC^CC CGTCTCC丁CC GTCTAAAGAA TCTCATAAAT CTCCAAACAT GTCTTACAAG CTGTGCCACC CCGAGGAGCT GGTGCTGCTC GGACACTCTC TGGGCATCCC (：TGGGC7CCC CTGAGCTCCT OCCCCAGCCA GGCCCTGCAG CTGGCAGGCT Gv：TTGAGCCA ACTCCATAGC GGCCTTTTCC TCTACCAGGG GCTCCTGCAG GCZCTGGA^G GGATATCCCC CGAGTTGGGT CCCACCTTGG ACACACTGCA '：iCTGGACGTC GCCGACTTTG CCACCACCAT CTGGCAGCAG ATGG^AGAAC TGGGAATGGC CCCTGCCCTG CAGCCCACCC AGGGTGCCAT GCCGGCCTTC >：rTCTGCTT TCCAGCGCCG GGCAGGAGGG GTCCTGGTTG CTAGCCATCT •：-.：AGAGCTTC CTGGAGGTGT CGTACCGCGT TCTACGCCAC CTTGCGCAGC ^^OGCGGCGG CTCTGACATG GCTACACCAT TAGGCCCTGC CAGCTCCCTG .'；：7CAGAGCT TCCTGCTC.^n GTCTTTAGAG C.^GTGAGGA AGATCCAGGG ：OATGGCGCA GCGCTCCAGG AG.^GCTGTG TGCCPvCCTAA T.\A; SZQ ID MO ： */ B

O:\92\92747.DOC -127- 200413407 OM0N15932 5 o 5 o 2 -·—- X t{ -—< f—f rir—ί -__^ -—< Ί-4-I—ί I—* Tx 1 Ί ^ ΊίΓ1 5 〇 5 o 5 o 5 o 5 o 5 〇 5 o 5 Q 5 o 5 1 2 2 3 3 4 4 5 5.-0 6 773399 ATGGCTAACT GCTCTATA.\T GATCGATGAA ATTATACATC ACTTAAAGAG ACCACCTGCA CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT CTATCCTGAT GGATCGAAAC CTTCGACTTC CAAACCTGGA GAGCTTCGTA AGGGCTGTCA AG^CTTAGA A^TGCATCA GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG CGGTGGAGGC TCCCCGGGTG ^CCGTCTGG TCCAJ\TCTCT ACTATCAACC CGTCTCCTCC GTCTAAAGAA TCTCATAAAT CTCCAAACAT GTCTCCCGAG TTGGGTCCCA CCTTGGACAC ACTGCAGCTG GACGTCGCCG ACTTTGCCAC CACCATCTGG CAGCAGATGG A-\GAACTGGG .\ATGGCCCCT GCCCTGCAGC CCACCCAGGG TGCCATGCC3 GCCTTCGCCT CTGCTTTCCA GCGCCGGGCA GGAGGGGTCC TGGTTGCTAG CCATCTGCAG AGCTTCCTGG AGGTGTCGTA CCGCGTTCTA CGCCACCTTG CGCAGCCCGG CGGCGGCTCT GACATGGCTA CACCATTAGG CCCTGCCAGC TCCCTGCCCC AGAGCTTCCT GCTC^GTCT TTAGAGC.^G TGAGGAAGAT CCAGGGCGAT GGCGCAGCGC TCCAGGAGAA GCTGTGTGCC ACCTACAAGC TGTGCCACCC CGAGGAGCTG GTGCTGCTCG GACACTCTCT GGGCATCCCC TGGGCTCCCC TGAGCTCCTG CCCCAGCCAG GCCCTGCAGC TGGCAGGCTG CTTGAGCC^A CTCCATAGCG GCCTTTTCCT CTACCAGGGG CTCCTGCAGG CCCTGGAAGG GATATCCTAA ΤΛΑ; S£Q ID NO :79 25 ?MON15965 35 40 45 5 i 101 151 201 251 301 351 401 451 501 551 601 551 701 7 51 801 351 901 951

ATGGCTAACT ACCACCTGCA CTATCCTGAT AGGGCTGTCA TAATCTCCAA CAATCATCAT rrim/-^rn -i. V- 1 J-V i Or-^j r~^ ^ τ' ^ λ r^· ^ ^ lwLrvr i CGTCTCCTCC TTCCAGCGCC C' r^n^r··' ^ Λ i Lj GCTCTGACAT TTCCTGCTCA AGCGCTCCAG AGCTGGTGCT TCCTGCCCCA TAGCGGCCTT 广广/^广一 PC rnrp L L L d，、7 -'Lj i i TTTGCCACCA CCTGCAGCCC

GCTCTATAAT CCTTTGCTGG GGATCGAAAC AGP^ACTTAGA CCATGTCTGC CAAGGCAGGT TTACCCTTGA丄 i U GTCTAAAGAA TCGTACCGCG GGCTACACCA AGTCTTTAGA GAGAAGCTGT GCTCGGACAC GCCAGGCCCT TTCCTCTACC GGGTCCCACC CCATCTGGCA ACCCAGGGTG

GATCGATGAA ACCCGAACAA 广、m m c 广、广 rp rp 為.；.Λ. AAATGCATCA CCTCTGCCAC GACTGGCAAG GCAAGCGCAG AACCGTCTGG TCTCATAAAT GGTCCTGGTT TTCTACGCCA TTAGGCCCTG GCAAGTGAGG GTGCCACCTA TCTCTGGGCA GCAGCTGGCA AGGGGCTCCT TTGGACACAC GCAGATGGAA CCATGCCGGC

ATTATACATC CCTCAATGAC CAAACCTGGA GGTATTGAGG GGCCGCACCC AATTCCGGGA GAACAACAGT TCCAATCTCT CTCCAAACAT GCTAGCCATC CCTTGCGCAG CCAGCTCCCT AAGATCCAGG CAAGCTGTGC TCCCCTGGGC GGCTGCTTGA GCAGGCCCTG TGCAGCTGGA GAACTGGGAA CTTCGCCTAA ACTTAAAGAG GAAGACGTCT GAGCTTCGTA CAATTCTTCG TCTCGACATC AAAACTGACG ACGTAGAGGG ACTATCAACC GT^^TCTOCT TGCAGAGCTT CCCGGCGGCG GCCCCAGAGC GCGATGGCGC CACCCCGAGG TCCCCTGAGC GCCAACTCCA GAAGGGATA'T CGTCGCCGAC TGGCCCCTGC TAA SEQ ID MO:80 PMONI5966 o 5 60

4 4 tn 5--0 6 I 33 9 9 1 1.- 11111111 0 5 0 5 0 5 0 5 0^,-

ATGGCTAACT ACCACCTGCA CTATCCTGAT AGGGCTGTCA TAATCTCCAA CAATC.VTCAT TTCTATCTGG C G G T G G AGG C CGTCTCCTCC m ^ w .OV—Vw、-丄、广广' p L Ό Xw 。 TGGAGGTGTC TCTGACATGG CCTGCTCAAG 〇 V- i v- ΛΟvjj /-ν rr> ^ rr^ /^> nry 1 L V- 1. Lj Vw -n- V- GCGGCCTTTT ：CCGAGTTCG TGCCACCACC

p 广 nr> 广 r*p、rn **\ ' <*Ή OV^. i. v- i i .-V-T'* x CCTTTGCTGG C-GATCGAAAC > rpm λ ^ 人 j. r\<jr\ CCATGTCTGC CAAGGCAGGT TTACCCTTGA rp广^1 广广广广P广 *、w ,w ·ν— _«w_0L· 〇 GTCTAAAGAA AGCCCACCCA GCAGGAGGGG U 1 i· l k r ‘一九 r\H *n 1 1 TCTTTAGAGC GAAGC丁GTGT TCGGACACTC CAGGCCCTGC CCTCTACCAG ,,m P 广、广,，π™ι rp V-j i ':Ί ^ · ATCTGGCAGC l <jr\ i U rv-A ACCCGAACAA 广/-prr»/^广、广、«•丄 ^ JL «» w > λ > rr>^y /-» ^ rn/^» λ CCTCTGCCAC GACTGGCAAG GCAAGCGCAG AACCGTCTGG TCTCA.TAAAT ^ ^ rr\ ^ ^ > .*n i LjL· γλ i Lj TCCTGGTTGC CTACGCCACC AGGCCCTGCC AAGTGAGGAA GCCACCTACA TCTGGGCATC λ ,-n ^ > Γ"* Γ^* j. GGGCTCCTGC GGACACACTG 下广 > /'or** i jOru-Λ·口‘Λ

ATTATACATC CCTCAATGAC CAAACCTGGA GGTATTGAGG GGCCGCACCC AATTCCGGGA GAACAACAGT TCCAATCTCT CTCCAAACAT CCGGCCTTCG TAGCCATCTG TTGCGCAGCC AGCTCCCTGC GATCCAGGGC AGCTGTGCCA CCCTGGGCTC CTGCTTGAGC AGGCCCTGGA CAGCTGGACG ACTGGGATAA ACTTAAAGAG GAAGACGTCT GAGCTTCGTA CAATTCTTCG TCTCGACATC AAAACTGACG ACGTAGAGGG ACTATCAACC GTCTATGGCC 广广 rp 广 rpc「rp,"prp CAGAGCTTCC CGGCGGCGGC CCCAGAGCTT GATGGCGCAG CCCCGAGGAG CCCTGAGCTC CAACTCCATA AGGGATATCC TCGCCGACTT TAA SEQ ID MO ： B1

70 pMONi5967 1 ATGGCT,\ACT GCTCTAT.^T GATCGATGAA ATTATACATC ACTTAAAGAG 51 ACCACCTGCA CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT L0.L CTATCCTGAT GGATCGP^XAC CTTCGACTTC C.\AACCTGGA GAGCTTCGTA 75 151 AGGGCTGTCA AGAACTTAGA AAATGCATCA GGTATTGAGG CAATTCTTCG

O:\92\92747.DOC -128- 200413407 10 15 20 25 30 35 40 2〇i T.^ATCTCC^ CCATGTCTGC CCTCTGCCAC GGCCGCACCC TCTCGACATC 251 C.^TCATCAT C.^GGCAGGT GACTGGC.^G AATTCCGGGA AAAACTGACG 301 TTCTATCTGG TTACCCTTGA GC.V\GCGCAG G.^ACAACAGT ACGTAGAGGG 351 CGGTGGAGGC TCCCCGGGTG AACCGTCTGG TCCAATCTCT ACTATC.\ACC 4Q1 CGTCTCCTCC GTTCTAAAGAA TCTCATAAAT CTCCAAACAT GTCTACCCAG 451 GGTGCCATGC CGGCCTTCGC CTCTGCTTTC CAGCGCCGGG CAGGAGGGGT SOI CCTGGTTGCT AGCCATCTGC AGAGCTTCCT GGAGGTGTCG TACCGCGTTC 551 TACGCCACCT TGCGCAGCCC GGCGGCGGCT CTGACATGGC TACACCATTA 501 GGCCCTGCCA GCTCCCTGCC CCAGAGCTTC CTGCTCAAGT CTTTAGAGCA AGTGAGGAAG ATCCAGGGCG ATGGCGCAGC GCTCCAGGAG AAGCTGTGTG 701 CCACCTACA.\ GCTGTGCCAC CCCGAGGAGC TGGTGCTGCT CGGACACTCT 751 CTGGGCATCC CCTGGGCTCC CCTGAGCTCC TGCCCCAGCC AGGCCCTGCA 301 GCTGGCAGGC TGCTTGAGCC .^CTCCATAG CGGCCTTTTC CTCTACCAGG 851 GGCTCCTGCA GGCCCTGGAA GGGATATCCC CCGAGTTGGG TCCCACCTTG 901 GACACACTGC AGCTGGACGT CGCCGACTTT GCCACCACCA TCTGGCAGCA 951 GATGGAAGAA CTGGGAATGG CCCCTGCCCT GCAGCCCTAA TAA 5H：Q ID MO: 32 PMON15960 1 ATGGCTACAC CATTGGGCCC TGCCAGCTCC CTGCCCCAGA GCTTCCTGCT 51 CAAGTCTTTA GAGCAAGTGA GGAAGATCCA GGGCGA/TGGC GCAGCGCTCC 101 AGGAGAAGCT GTGTGCCACC TACAAGCTGT GCCACCCCGA GGAGCTGGTG 151 CTGCTCGGAC ACTCTCTGGG CATCCCCTGG GCTCCCCTGA GCTCCTGCCC 201 CAGCCAGGCC CTGCAGCTGG CAGGCTGCTT GAGCCAACTC CATAGCGGCC 251 TTTTCCTCTA CCAGGGGCTC CTGCAGGCCC TGGA.^GGGAT ATCCCCCGAG 301 TTGGGTCCCA CCTTGGACAC ACTGCAGCTG GACGTCGCCG ACTTTGCCAC 351 CACCATCTGG CAGCAGATGG AAC-AACTGGG AATGGCCCCT C-CCCTGCAGC 401 CCAGCCAGGG TGCCATGCCG GCCTTCGCCT CTGCTTTCCA GCGvCCGGGCA 451 GGAGGGGTCC TGGTTGCTAG CCATCTGCAG AGCTTCCTGG AGGTGTCGTA 5 01 CCGCGTTCTA CGCCACCTTG CGCAGCCCGG CGGCGGCTCT GACATGGCTA 551 CACCATTGGG CCCTGCCAGC TCCCTGCCCC AGAGCTTCCT GCTCAAGTCT 601 TTAGAGCAAG TGAGGAAGAT CCAGGGCGAT GGCGCAGCGC TCCAGGAGAA 651 GCTGTGTGCC ACCTACAAGC TGTGCCACCC CGAGGAGCTG GTGCTGCTCG 701 GACACTCTCT GGGCATCCCC TGGGCTCCCC TGAGCTCCTG CCCCAGCCAG 751 GCCCTGCAGC TGGCAGGCTG CTTGAGCCAA CTCCATAGCG GCCTTTTCCT 301 CTACCAGGGG CTCCTGCAGG CCCTGGAAGG GATATCCCCC GAGTTGGGTC 851 CCACCTTGGA CACACTGCAG CTGGACGTCG CCGACTTTGC CACCACCATC 901 TGGCAGCAGA TGGA-^GAACT GGGAATGGCC CCTGCCCTGC AGCCCACCCA 1001 TCCTGGTTGC TAGCCATCTG CAGAGCTTCC TGGAGGTGTC GTACCGCGTT 1051 CTACC-CCACC TTGCGCAGCC CTGATAA SEQ ID NO :33

PMON32132 45 50 55 60 65 70 TCTCCCGCTCCGCCTGCTTGTGACCTCCGAGTCCTCAGTAAACTGCTTCGTGACTCCCATGTCCTTCACAGCAGA CTGAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTCCTGCTGCCTGCTGTGGACTTTAGCTTGGGAGP'-A TGGAAJVACCCAGATGGAGGAGACCAAGGCACAGGACATTCTGGGAGCAGTGACCCTTCTGCTGGAGGGAGTGATG GCAGCACGGGGACAACTGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAGCTTTCTGGACAGGTCCGTCTCCTC CTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGCTTCCTCCACAGGGCAGGACCACAGCTCACAAGGATCCC^AT GCCATCTTCCTGAGCTTCC.^CACCTGCTCCGAGGAAAGGTGCGTTTCCTGATGCTTGTAGGAGGGTCCACCCTC TGCGTCAGG SEQ ID MO :34 、 PMOM32133 TCTCCCGCTCCGCCTGCTTGTGACCTCCGAGTCCTCAGTAAACTGCTTCGTGACTCCCATGTCCTTCACAGCAGA CTG^GCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTCCTGvCTGCCTGCTGTGGACTTTAGCTTGGGAGAA TGGA^^CCCAGATGGAGGAGACCA-AGGCACAGGACATTCTGGGAGCAGTGACCCTTCTGCTGGAGGGAGTGATG GCAGCACGGGGAC^CTGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAGCTTTCTGGACAGGTCCGTCTCCTC CTTGGGGCCCTGCAGAGCCTCCTTGGAACCCAGGGCAGGACCACAGCTCAC^GGATCCC^TGCCATCTTCCTG AGCTTCC^CACCTGCTCCGAGG^AGGTGCGTTTCCTGATGCTTGTAGGAGGGTCCACCCTCTGCGTCAGG SEQ ID MO :35 pMON3 213 4 TCCCCAGCGCCGCCTGCTTGTGACCTCCGAGTCCTCAGT^\ACTGCTTCGTGACTCCCATGTCCTTCACAGCAGA C^GAGCCAGTGCCCAGAGGTTCACCCTTTGCCTACACCTGTCCTGCTGCCTGCTGTGGACTTTAGCTTGGGAGA.^ TGGr^^CCCAGATGGAGGAGACC.^GGCACAGGACATTCTGGGAGCAGTGACCCTTCTGCTGGAGGGAGTGATG GCAGTACGGGGAC.^CTGGGACCCACTTGCCTCTCATCCCTCCTGGGGCAGCTTTCTGGACAGGTCCGTCTCCTC CTTGGGGCCCTGCAGAGCCTCCTTGGA.sCCCAGCTTCCTCCACAGGGCAGGACCACAGCTCAC^GGATCCCAAT GCCATCTTCCTGAGCTTCC.^CACCTGCTCCGAGG^AGGTGCGTTTCCTGATGCTTGTAGGAGGGTCCACCCTC TGCGTCAGG JSQ ID NO：36

Pmoni 3 1. S ί ! CCATGGCT^ CTGCTCTATA ATGATCGATG AAATTATACA TCACTTAAAG 75 agaccacctg cacctttgct GGACCCGAAC AACCTCAATG acgaagacgt

O:\92\92747.DOC -129- 200413407 5 101 CTCTATCCTG ATGGATCGA.^ ACCTTCGACT TCCAAACCTG GAGAGCTTCG L51 TAAGGGCTGT CA.^GAACTTA GAAAATGCAT CAGGTATTGA GGCAATTCTT 201 CGTAATCTCC AACCATGTCT GCCCTCTGCC ACGGCCGCAC CCTCTCGACA 251 TCCAATCATC ATCAAGGCAG GTGACTGGCA AGAATTCCGG GAAAAACTGA 301 CGTTCTATCT GGTTACCCTT GAGC^GCGC AGGAACAACA GTACGTAgag 351 ggcggtggag gctcCCCGGG TGAACCG丁CT GGTCCAATCT CTACTATCAA 401 CCCGTCTCCT CCGTCTAAAG AATCTCATAA ATCTCCAAAC ATGTAAGGTA 451 CCGCATGCAA GCTT 5EQ ID MO：37 10 PmonI3130.Seg 15 20 I CCATGGCT.^A CTGCTCTATA ATGATCGATG ^J^ATTATACA TCACTTAAAG 51 AGACCACCTG CACCTTTGCT GGACCCGAAC AACCTCAATG ACGAAGACGT 101 CTCTATCCTG ATGGATCGAA ACCTTCGACT TCC.^AACCTG GAGAGCTTCG 151 Ti^AGGGCTGT CAAGAACTTA GAAAATGCAT CAGGTATTGA GGCAATTCTT 201 CGTAATCTCC AACCATGTCT GCCCTCTGCC ACGGCCGCAC CCTCTCGACA 251 TCCAATCiVTC ATCAAGGCAG GTGACTGGCA AGAATTCCGG GAAAAACTGA 301 CGTTCTATCT GGTTACCCTT GAGCAAGCGC AGGAACAACA GTACGTAgag 351 ggcggtggag gcccCCCGGG TGGTGGTTCT GGCGGCGGCT CCAACATGTA 401 AGGTACCGCA TGC^GCTT SEQ ID NO: 38 pM〇N30237.seq GCCACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGC 25 TGTCAAAATCCGTGAC-CTGTCTGACTACCTGCTTCAAGATTACCCAGTCA CCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGCGCTCTGGCGG CTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTC CAAGATGC.^GGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCA CCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCC-TCCAGACC 30 AACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAA GCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTC AGCCC SEQ ID NO :89

35 pMOM30233.seq GCCACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGC TGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTC.^AGATTACCCAGTCA CCGTGGCCTCC.\ACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGG 40 CTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC.^AGACTGTCGCTGGGTC CAAGATGCA^.GGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCA CCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC AACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGA.^ GCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTC 45 AGCCCGACTCCTCAACCCTG SEQ ID MO :90 pMOM30239.seq 50 GCCACCCAGGACTGCTCCTTCC.^ACAC'AGCCCCATCTCCTCCGACTTCGC TGTCAAA.^.TCCGTGAGCTGTCTGACTACCTGCTTC^GATTACCCAGTCA CCGTGGCCTCC?>ACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGG CTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC.---\GACTGTCGCTGGGTC CAAGATGCA^.GCCTTGCTGGAGCGCGTGP^CACGGAGATACACTTTGTCA 55 CCPu\ATGTGCCTTTCAGGAGACCTCCGAGCAGCTGGTGGCGCTG^ GCCCTGGATCACTCGCCAG.^ACTTCTCCCGGTGCCTGGAGCTGCAGTGTC AGCCCGACTCCTCAACCCTG S£Q ID MO :91

60 pMOM3 2 3 2 9.seq GGAACTCAGGATTGTTCTTTCC^CACAGCCCC.\TCTCCTCCGACTTCGC TGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCA • CCGTGGCCTCC.^ACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGG ctggtcctggcacagcgctggatggagcggctc.^gactgtcgctgggtc C^GATGC^GGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCA CCA^^TGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC .\ACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGvl*TGGTGGCGCTGA.X GCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTC 70 AGCCC SEQ ID M〇：92

PMON32 3 3 G . jeq 75 CGTACCCAGGATTGTTCTTTCC^\CACAGCCCCATCTCCTCCGACTTCCC

O:\92\92747.DOC -130- 200413407 TGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCA CCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGG CTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTC CAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCA 5 CCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC AACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAA GCCCTGGATCACTCGCCAGP^ACTTCTCCCGGTGCCTGGAGCTGCAGTGTC AGCCCGACTCCTCAACCCTG SEQ ID NO :93 10 pMON3 2 3 4 I.seq GCCACTCAGGACTGTTCTTTCC.^ACACAGCCCCATCTCCTCCGACTTCGC TGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTTACCCAGTCA 15 CCGTGGCCTCC.\ACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGG CTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTC CAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCA CCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC AACATCTCCCC-CCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAA 20 GCCCTGGATCACTCGCCAG^CTTCTCCCGGTGCCTGGAGCTGCAGTGTC AGCCC SEQ ID NO :94 PMQN32342.seq 25 GCCACTCAGGACTGCTCTTTTCAACACAGCCCCATCTCCTCCGACTTCGC TGTC^^AATCCGTGAGCTGTCTGACTACCTGCTTC.^AGATTACCCAGTCA CCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGG CTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTC 30 CAAGATGCA*\GGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCA CCA.^.TGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC AACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTG*^A GCCCTGGATCACTCGCCAGA--.CTTCTCCCGGTGCCTGGAGCTGCAGTGTC AGCCCGACTCCTCAACCCTG SEQ ID NO :95 35 pMOM32320.seq GCCGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCG 40 CTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCA^.GATGCAAGGCTTGC TGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAG CCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC\ACATCTCCCGCCTCCT GCAGGAGACCTCCGAGCAGCTGGTGGCGCTGPu\GCCCTGGATCACTCGCC AGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACC 45 CTGTCTGGAGGTAACGGATCCGGTGGCAATGGGAGCGGCGGAAATGGAAC CCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCA A.^ATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTG GCCTCCAACCTGCAG SEQ ID MO :95 50 、 pMOM323 2 I .seq GCCGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCG CTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCC^GATGCAJ\GGCTTGC 55 TGGAGCGCGTG^.CACGGAGATACACTTTGTCACC.^^rGTGCCTTTCAG CCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC.-.ACATCTCCCGCCTCCT GCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCC AGA^.CTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTC^CC CTGTCAGGCGGT.^.CGGCAGTGGAGGT*\ATGGCACCCAGGACTGCTCCTT 60 CCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGT CTGACTACCTGCTTC^GATTACCCAGTCACCGTGGCCTCCAACCTGCAG ScQ ID NO：97 65 pMCM3：322.〇eq

GCCGACG.^GGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCG

CT'GGATCJGAGCGGCT'CAAGACTGTCGCTGGC/TCCAAGATGCAAGGCTT'GC

TGGAGCGCGTG.\ACACGGAGATACACTTTGTCACC.\AATGTGCCTTTCAG 70 CCCCCCCCCACjCTGTCTTCGCTTCGTCCAGACC.^ACATCTCCCCCCTCCT GCAGGAGACCTCCGAGCAGCTGGTGGCGCTG.\AGCCCTGGATCACTCGCC AGA^\CT7CTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTC^CC CTGTCTGCCCGC^CGGCACCCAGGACTGCTCCTTCC.^ACACAGCCCCAT CTCCTCCGACTTCGCTGTC.\AAATCCCTGAGCTGTCTGACTACCTGCTTC 75 A.^GATTACCCAGTCACCGTGGCCTCC.\ACCTGCAG SEQ ：D NO : 93 131 -

O:\92\92747.DOC 200413407 PMON32323.seq 5 GCCTCC.^AGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTT TGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCC AGACC^CATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCG CTGAAGCCCTGGATCACTCGCCAG^CTTCTCCCGGTGCCTGGAGCTGCA GTGTCAGCCCGACTCCTCAACCCTGTCTGGAGGTA.\CGGATCCGGTGGCA 10 ATGGGAGCGGCGGAAATGGAACCCAGGACTGCTCCTTCCAACACAGCCCC ATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCT TC.^AGATTACCCAGTCACCGTGGCCTCC^CCTGCAGGACGAGGAGCTCT GCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC AAGACTGTCGCTGGG SEQ ID NO:99 15 PMOM32324.seq

GCCTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTT 20 TGTCACC*\AATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCC AGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCG CTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCA GTGTCAGCCCGACTCCTCAACCCTGTCTGGAGGTAACGGATCCGGAGGTA ATGGCACCCAGGACTGCTCCTTCC.\ACACAGCCCCATCTCCTCCGACTTC 25 GCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTC.^AGATTACCCAGT CACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGC GGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCA.\GACTGTCGCTGGG SEQ ID MO:100 30 PMON32325.seq 、 GCCTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTT TGTCACCAA^.TGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCC AGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCG 35 CTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCA GTGTCAGCCCGACTCCTC^J\CCCTGTCTGGCGGCA.\CGGCACGCAGGACT GCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGT GAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAA CCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCAC 40 AGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGG SEQ ID NO: 101 PMON323 26. sec

45 GCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCT GCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCC AGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACC CTGTCTGGAGGTAACGGCAGTGGTGGCAATC-GGAGCGGTGGAAATGGAAC CCAGGACTGCTCCTTCCAACACAGCCCqATCTCCTCCGACTTCGCTGTCA 50 AAATCCGTGAGCTGTCTGACTACCTGCTTC^.GATTACCCAGTCACCGTG

GCCTCC^.CCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGT CCTGGCACAGCGCTGGATGGAGCGGCTC^.GACTGTCGCTGGGTCC^GA TGC^GGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACC.\AA _ TGTGCCTTTCAGCCC SEQ ID NO:102 PMON32327.seq 60 GCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC.^ACATCTCCCGCCTCCT GCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCC AGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCA.\CC CTGTCAGGCGGTA.\CGGCAGTGGAGGTAATGGCACCCAGGACTGCTCCTT CCA^.CACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGT 65 CTGACTACCTGCTTC.^AGATTACCCAGTCACCGTGGCCTCCAACCTGCAG GACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTG GATGGAGCGGCTCAAGACTGTCGCTGGGTCC.^AGATGCAAGGCTTGCTGG AGCGCOTG.^CACGGAGATACACTTTGTCACC.^AATGTGCCTTTCAGCCC SEQ :3 ：]〇： 103 70 pMOM3：3：8.seq

GCCCCCCCCAGCTCTCTTCGCTTCGTCCAGACC.\.ACATCTCCCGCCTCCT 75 GCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCCCC

O:\92\92747.DOC 132- 200413407 AGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTC^CC CTGTCTGGCGGCAACGGCACGCAGGACTGCTCCTTCCAACACAGCCCCAT CTCCTCCGACTTCGCTGTC^\AATCCGTGAGCTGTCTGACTACCTGCTTC _ AAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGC 5 GGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC.\A GACTGTCGCTGGGTCCA^.GATGCAAGGCTTGCTGGAGCGCGTGAACACGG AGATACACTTTGTCACCAAATGTGCCTTTCAGCCC SEQ ID NO :104 10 PMCN32343.seq GCCGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCG CTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGC TGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAAT'GTGCCTTTCAG 15 CCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC.\ACATCTCCCGCCTCCT GCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCC AGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACC CTGTCTGGAGGTAGTGGATCCGGAGGTTCTGGCA.^CCCAGGACTGCTCCT TCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTG 20 TCTGACTACCTGCTTCAAGATTA.CCCAGTCACCGTGGCCTCCAACCTGCAG SEQ ID NO：105 pMON32350.seq

25 GCCGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCG CTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGC TGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAG CCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCT GCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCC 30 AGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACC CTGTCTGGAGGTAGTGGATCCGGTGGCAGTGGGAGCGGCGGATCTGGAAC CCAGGACTGCTCCTTCC^J\CACAGCCCCATCTCCTCCGACTTCGCTGTCA AAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTG GCCTCCAACCTGCAG SEQ ID MO:106 35 FLT3N.seq CCATGGCCACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGAC 40 TTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTC.\AGATTACCC AGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCT GGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCT GGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGA.GATACACTT TGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCC 45 AGACC^CATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCG CTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCA GTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGATCC SZQ ID NO:IG7

50 FLT3C.seq GGATCCGGAGGTACCCAGGACTGCTCCTTCC^CACAGCCCCATCTCCTC CGACTTCGCTGTC^AATCCGTGAGCTGTCTGACTACCTGCTTC^GATT 55 ACCCAGTCACCGTGGCCTCC.^CCTGCAGGACGAGGAGCTCTGCGGGGGC CTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC^GACTGT CGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATAC ACTTTGTCACC^-.TGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTC GTCCAGACC^CATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGT 60 GGCGCTG^GCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGC TGCAGTGTCAGCCCGACTCCTC^CCCTGTAAGCTT SEQ ID MO: 103 65 FLT7M.seq

CCATGGCCACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGAC

TTCGCTGTC^^VICCGTGAGCTGTCTGACTACCTGCTTC^GATTACCC

AGTCACCGTGGCCTCC.VvCCTGCAGGACGAGGAGCTCTGCGGGGGCCTCT

70 GGCGGCT3GTCCTGGCACAGCGCTGGATGGAGCGGCTC.\AGACTGTCGCT

GGGTCC.-^GATGCA^GGCTTGCTGGAGCGCGTGAACACGGAGATACACTT TGTCAC".：^VaTGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCT?CGTCC AGACC.-V\CATCTCCCGCCTCCTOCAGGAGACCTCCGAGCAGCTGGTGGCG CTGAAGCCCTCGATC.\CTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCA 75 GTGTCAGCCCGr\CTCCTC.\ACCCTGGGCGGTGGGTCAGGAGGTGGATCC

O:\92\92747.DOC -133 - 200413407 SEQ ID NO：109 5 FLT4C.seq GGATCCGGAGGTGGCACCCAGGACTGCTCCTTCC^CACAGCCCCATCTC CTCCGACTTCGCTGTCA.\AATCCGTGAGCTGTCTGACTACCTGCTTC.\AG ATTACCCAGTCACCGTGGCCTCC^CCTGCAGGACGAGGAGCTCTGCGGG 10 GGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC*\AGAC TGTCGCTGGGTCCAAGATGC^GGCTTGCTGGAGCGCGTGAACACGGAGA TACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGC TTCGTCCAGACC.^ACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCT GGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGG 15 AGCTGCAGTGTCAGCCCGACTCCTCAACCCTGTAAGCTT SEQ ID MO:110 FLTllM.seq 20

CCATGGCCACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGAC TTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTC^-AGATTACCC AGTCACCGTGGCCTCC^CCTGCAGGACGAGGAGCTCTGCGGGGGCCTCT GGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC.^AGACTGTCGCT 25 GGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTT TGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCC AGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCG CTG^GCCCTGGATCACTCGCCAGA^.CTTCTCCCGGTGCCTGGAGCTGCA GTGTCAGCCCGACTCCTC*\ACCCTGGGCGGTGGGTCAGGAGGTGGGTCAG 30 GAGGTGGATCC SEQ ID MO:ill FLT10C.seq

35 GGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTT CCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGT CTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAG GACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTG GATGGAGvCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGG 40 AGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCC CCCCCCAGCTGTCTTCGCTTCGTCCAGACC.^CATCTCCCGCCTCCTGCA GGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGA ACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCA-ACCCTG TAAGCTT SEQ ID MO:112 45 - pMON3 2 3 6 5.seq

GCCGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCG 50 CTGGATGGAGCGGCTCAAGACTGTCGCiGGGTCCAAGATGC.\AGGCTTGC TGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAG CCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCT GCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCC AGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTC^CC 55 CTGGGCGGTGGATCCGGAGGTACCCAGGACTGCTCCTTCC^CACAGCCC CATCTCCTCCGACTTCGCTGTC.^AAATCCGTGAGCTGTCTGACTACCTGC TTC^GATTACCCAGTCACCGTGGCCTCCAACCTGCAG SEQ ID NO :113 60 pMCM32366.seq

GCCGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCG CTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCiAGGCTTGC TGGAGCGCGTGP*u\CACGGAGATACACTTTGTCACC^\ATGTGCCTTTCAG 65 CCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC^ACATCTCCCGCCTCCT GCAGGAGACCTCCGAGCAGCTGGTGGCGCTGA-\GCCCTGGATCACTCGCC AGAACTTCTCCCGGTCCCTGGAGCTGCAGTGTCAGCCCGACTCCTC.\ACC CTGGGCGGTGGATCCGGAGGTGGCACCCAGGACTGCTCCTTCC^CACAG CCCCATCrCCTCCGACTTCGCTGTC^-^ATCCGTGAGCTGTCTGACTACC 70 tgcttc.^gattacccagtcaccotgocctcc.ViCCTGCAG 5ZQ ID MO：114 ρΜΟΓΐ3：3 6~· . seq

75 GCCGACGAGGAGCTCTGCGGGGGCCTCTCGCGGCTGGTCCTGGCACAGCG

O:\92\92747.DOC -134- 200413407 ctggatggagcggctc.\agactgtcgctgggtcc4\agatgc^ggcttgc TGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAG CCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC.^ACATCTCCCGCCTCCT GCAGGAGACCTCCGAGCAGCTGGTGGCGCTGA.^GCCCTGGATCACTCGCC 5 AGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTC.\ACC CTGGGCGGTGGGTCAGGAGGTGGATCCGGAGGTACCCAGGACTGCTCCTT CC^CACAGCCCCATCTCCTCCGACTTCGCTGTC.\AAATCCGTGAGCTGT CTGACTACCTGCTTC.\AGATTACCCAGTCACCGTGGCCTCC.^CCTGCAG SEQ ID MO：115 10 PMOM32363.seq GCCGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCG CTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGC 15 TGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAG CCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCT GCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCC AGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTC^CC CTGGGCGGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGA 20 CTGCTCCTTCCAACACAGCCCCATCTCCTCCGAC丁TCGCTGTCAAAATCC GTGAGCTGTCTGACTACCTGCTTC^GATTACCCAGTCACCGTGGCCTCC AACCTGCAG SEQ ID M0:1I6

25 pMON32369.seq GCCGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCG CTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTCC TGGAGCGCGTGPvACACGGAGATACACTTTGTCACC^ATGTGCCTTTCAG 30 CCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCT GCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCC AGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACC CTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCAC CCAGGACTGCTCCTTCCA^.CACAGCCCCATCTCCTCCGACTTCGCTGTCA 35 AAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTG GCCTCCAACCTGCAG SEQ ID NO :117 pM〇N32370.seq 40

GCCGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCG CTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGC TGGAGCGCGTG-^ACACGGAGATACACTTTGTCACCAP-ATGTGCCTTTCAG CCCCCCCCCAGCTGCCTTCGCTTCGTCCAGACCA.^CATCTCCCGCCTCCT 45 GCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCC AG^CTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACC CTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTC AGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCC.^.CACAGCCCCATCT CCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAA 50 GATTACCCAGTCACCGTGGCCTCCAACi.TGCAG SEQ ID >J〇 : i 13 PMON3 02 47. sea GCT^CTGCTCTATAATGATCGATGA^JkTTATACATCACTT^^GAGACC 55 ACCTGCACCTTTGCTGGACCCG^C.^CCTCP'-ATGACG.^GACGTCTCTA TCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAGC丁TCGTWAGG GCTGTCMGAACT'TAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA TCTCC^.CCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCC^ TCATCATC^.GGCAGGTGACTGGCP'AGAATTCCGGG.-AAAACTGACGTTC 60 TATCTGGTTACCCTTGAGC^GCGCAGGAAC^ACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCACCCAGGAC TGCTCCTTCCt\ACACAGCCCCATCTCCTCCGACTTCGCTGTCAPAATCCG' TGAGCTGTCTGACTACCTGCTTC.^GATTACCCAGTCACCGTGGCCTCCA 65 ACCTGCAGGACGAGGAGCTCTGCGGGGCGCTCTGGCGGCTGGTCCTGGCA CAGCGC丁GGATGGAGCGGCTCAAGACTGT'CGCTGGGTCCAAGATGCAAGG CTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCT1 TTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC.-V^CATCTCCCGC CTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCAC 70 TCGCCAGAACTTCTCCCGGTGCCTGOAGCTGCAGTGTCAGCCC 5ZQ ]：D NO:丄 19 pMON3G：4R . ：3>2q

75 '.；CT.\.\CTGCTCTAT^TGATCGrtTGAAATTATACATCACTT,\A*^GAGACC

O:\92\92747.DOC 135- 200413407 ACCTGCACCTTTGCTGGACCCGAACA.^CCTC.^TGACGAAGACGTCTCTA TCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAGCTTCGTAAGG GCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCrTCGTAA ^ TCTCC.^ACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA 5 TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAA^CTGACGTTC TATCTGGTTACCCTTGAGCA^.GCGCAGGAAC^CAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCACCCAGGAC TGCTCCTTCC.V^CACAGCCCCATCTCCTCCGACTTCGCTGTCAA^^TCCG 10 TGAGCTGTCTGACTACCTGCTTCP^.GATTACCCAGTCACCGTGGCCTCCA ACCTGCAGGACGAGGAGCTCTGCGGGGCGCTCTGGCGGCTGGTCCTGGCA CAGCGCTGGATGGAGCGGCTC.^AGACTGTCGCTGGGTCCAi^.GATGCAAGG CTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACC^^TGTGCCT TTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGC 15 CTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTG^GCCCTGGATCAC TCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCT CAACCCTG SEQ ID NO：120 20 pMOM3 2 3 3 2.seq

GCTAACTGCTCTATAATGATCGATG.\A.\TTATACATCACTTA^JVGAGACC ACCTGCACCTTTGCTGGACCCGAACAACCTC.\ATGACGAAGACGTCTCTA TCCTGATGGACCGAAA.CCTTCGACTTCC.\AACCTGGAGAGCTTCGTAAGG 25 GCTGTC.\AGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGT*\A TCTCC.^ACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAAGTGACGTTC TATCTGGTTACCCTTGAGC^GCGCAGGA.\CAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGT'CTGGTCCAAT'CTCTACTATCAACCCGT 30 CTCCTCCGTCTAAAG^TCTCAT^AATCTCCA.^CATGGCCGACGAGGAG CTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCG GCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGA ACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGC TGTCTTCGCTTCGTCCAGACC.\ACATCTCCCGCCTCCTGCAGGAGACCTC 35 CGAGCAGCTGGTGGCGCT'GAAGCCCTGGATCACTCGCCAGAACTTCTCCC GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCA^.CCCTGTCAGGCGGT AACGGCAGTGGAGGTAATGGCACCCAGGACTGCTCCTTCCAACACAGCCC CATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCT'GACTACCTGC TTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAG SEQ ID MO : 12 1 40 pMON32333.seq 45 50 60 GCT^CTGCTCTATAATGATCGATGA.^TTATACATCACTTAAAGAGACC ACCTGCACCTTTGCTGGACCCGAAC*\ACCTCAATGACGAAGACGTCTCTA TCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAGCTTCGITAAGG GCTGTC.\AGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA TCTCC.^ACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA TCATCATCAAGGCAGG丁GACTGGCAAGAATTCCGGGAAAAACTGACGTTCΛ ^ ^ λ 、广 όλ λ λ ^ ^ λ ^ ^ 1- X Λ, Λ. ^ V_? J A^*b 'Ί—J ^ ·—Ϊ X V»- "sj* TGGAGGCTCCCCGGGTGAACCGTCTGGTCC^TCTCTACTATC^CCCGT CTCCTCCGTCTAAAGAATCTCAT 入AATCTCCAAACATGGCCGACGAGGAG CTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCG GCTCA.AGACTGTCGCTGGGTCC；^AGATGCAAGGCTTGCTGGAGCGCGTGA ACACGGAGATACACTTTGTCACCA.^\TGTGCCTTTCAGCCCCCCCCCAGC TGTCTTCGCTTCGTCCAGACC.^ACATCTCCCGCCTCCTGCAGGAGACCTC CGAGCJVGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCC GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTC^CCCTGTCTGGAGGT oLj/Λ I λ AA I I 1 I CTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGC TGTCTGACTACCTGCTTC^GATTACCCAGTCACCGTGGCCTCC^.CCTG CAG SEQ ID MO : i22

65 pMOM32 3 3-； . seq

GCTA,\CTGCTCTAT.\ATGATCGATGAAATTATACATCACTT^\AGAGACC ACCTGCACCT'TTGCT'GGACCCGAACAACCTCAATGA.CGAAGACGTCTCTA TCCTGATGGACCG；^\CCTTCGACTTCC.^^CCTGGAGAGCTTCGTAAGG 70 GCTCTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGT'AA TCTCC.-^CCATGTCTGCCCTCTGCCACGGCCCCACCCTCTCGACATCCAA TCATCA 丁 CAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC TATCT^GTTACCCTTGr\GC.\.-\GCGCAGG.^CA.^CAGTACG7AGAGGGCGG TGGAGGCTCrCCGGGTGA^CCGTCTCGTCCPunTCTCTACTATC.^CCCGT 75 CTCCTCCGTCT.^A.^GAATCTCAT.^AATCTCC.\*\ACATGGCCTCC.^AGATG

O:\92\92747.DOC -136- 200413407 CAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACC.\AATG TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC.\ACATCT CCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGG ATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGA CTCCTCAACCCTGTCTGGCGGCAACGGCACGCAGGACTGCTCCTTCCAAC ACAGCCCCATCTCCTCCGACTTCGCTGTCAA.\ATCCGTGAGCTGTCTGAC TACCTGCTTCAAGJVTTACCCAGTCACCGTGGCCTCCAACC丁GCAGGACGA GGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGG AGCGGCTC.^GACTGTCGCTGGG SEQ ID MO :12 3 PMON32335.〇eq

GCTA.^CTGCTCTAT.\ATGATCGATGAAATTATACATCACTTAA.\GAGACC 15 ACCTGCACCTTTGCTGGACCCGAACAACCTCAATGACGAAGACGTCTCTA TCCTGATGGACCGAAACCTTCGACTTCC^^ACCTGGAGAGCTTCGT^GG GCTGT.CAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA TCTCC^CCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCC.^ TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAA.^AACTGACGTTC 20 TATCTGGTTACCCTTGAGC.^AGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACAT'GGCCT'CCAAGATG CAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATG TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCT 25 CCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGA*AGCCCTGG ATCACTCGCCAG^CTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGA CTCCTCAACCCTGTCTGGAGGTAACGGATCCGGAGGTAATGGCACCCAGG ACTGCTCCTT'CCAACACAGCCCCATCTCCTCCGACTTCGCTGT'CAAAATC CGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTC 30 CAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGG CACAGCGCTGGATGGAGCGGCTC.^AGACTGTCGCTGGG SEQ ID NO:124 35 40 45 50 55 pMOM3 2 3 3 6.seq GCTA^.CTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC ACCTGCACCTTTGCTGGACCCGAACAACCTCAATGACGAAGACGT'CTCTA TCCTGATGGACCGA?^CCTTCGACTTCCAAACCTGGAGAGCTTCGTAAGG GCTGTCAAGAACTTAGAAAATGCJVTCAGGTATTGAGGCAATTCTTCGTAA TCTCC.\ACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCC.^\ TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACOGTCTGGTCCAATCTCTACTATCAACCCGT CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCTCCAAGATG CAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATG TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCT CCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGG ATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGA CTCCTC^CCCTGTCTGGAGGT^ACGG^TCCGGTGGCAATGGGAGCGGCG GAAATGGAACCCAGGACTGCTCCTTCCPJ\CACAGCCCCATCTCCTCCGAC TTCGCTG丁CAAAATCCGTGAGCTGTCTGACTACCTGCTTC.WGATTACCC AGTCACCGTGGCCTCC^CCTGCAGGACGAGGAGCTCTGCGGGGGCCTCT GGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC.VvGACTGTCGCT GGG SEQ ID MO: 12 5 PMCM32337.seq

GCT^CTGCTCTAT.^TGATCGATGAAATTATACATCACTT.^AGAGACC 60 ACCTGCACCTTTGCTGGACCCG^CAACCTC.\-\TGACGAAGACGTCTCTA TCCTGATGGACCGAA.i.CCTTCGACTTCC.\A*\CCTGGAGAGCTTCGTAAGG GCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA TCTCC^CCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC 65 TATCTGGT'TACCCTT'GAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT CTCCTCCGTCT.\AAG^TCTCATA.\ATCTCCAAACATGGCCCCCCCCAGC TGTCTTCGCTTCGTCCAGACC^CATCTCCCGCCTCCTGCAGC-AGACCTC CGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCC

70 GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTC.^CCCTGTCTGGCGGC AACGGCACCCAGGACTGCTCCTTCC^CACAGCCCCATCTCCTCCGACTT CGCTG丁CAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAG TCACCCTGGCCTCC.^CCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGG CGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC.^GACTGTCGCTGG 75 GTCCA^XGATGC^GGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTG

O:\92\92747.DOC 137- 200413407 TCACCA.^TGTGCCTTTCAGCCC 3EQ ID NO: 12 β OM0N32333.seq 5 GCT^CTGCTCTAT^TGATCGATGAA.\TTATACATCACTT^AAGAGACC ACCTGCACCTTTGCTGGACCCGAACAACCTCAATGACGAAGACGTCTCTA TCCTGATGGACCGAAACCTTCGACTTCCAAACCTGGAGAGCTTCGTAAGG GCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAArrCTTCGTAA 10 TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC TATCTGGTTACCCTTGAGC^AGCGCAGGAACPu^CAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCC^J\TCTCTACTATCAACCCGT CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCCCCCCCAGC 15 TGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTC CGAGCAGCTGGTGGCGCTGAAGCCCTG.GATCACTCGCCAGAACTTCTCCC GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTC^CCCTGTCAGGCGGT AACGGCAGT'GGAGGTAATGGCACCCAGGACTGCT'CCTTCCAACACAGCCC CATCTCCTCCGACTTCGCTGTC.\AAATCCGTGAGCTGTCTGACTACCTGC 20 TTCA^.GATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTC TGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCT CAAGACTGTCGCT'GGGTCCAAGPvTGCAAGGCT'TGCTGGAGCGCGTGAACA CGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCC SEQ ID MO:127

25 OM0N32339.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC ACCTGCACCTTTGCTGGACCCGAACAACCTCAATGACGAAGACGTCTCTA 30 TCCTGiVTGGACCGAAACCTTCGACTTCCAAACCTGGAGAGCTTCGTAAGG GCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCC^A TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC TATCTGGTTACCCTTGAGCAAGCGCAGG.\AC^CAGTACGTAGAGGGCGG 35 TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCCCCCCCAGC TGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTC CGAGCAGCTGGTGGCGCTGA^.GCCCTGGATCACTCGCCAGAACTTCTCCC GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTC^CCCTGTCTGGAGGT 40 AACGGCAGTGGTGGTAATGGGAGCGGCGGAAATGGAACCCAGGACrGCTC CTTCCAACACAGCCCC.VTCTCCTCCGACTTCGCTGTCAAAATCCGTGAGC TGTCTGACTACCTGCTTC^AGATTACCCAGTCACCGTGGCCTCCAACCTG CAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCG CTGGATGGAGCGGCTCAAC-ACTGTCGCTGGGTCCAAGATGCAAGGCTTGC 45 TGGAGCGCGTGA^.CACGGAGATACACTTTGTCACCAA^.TGTGCCTTTCAG CCC SEQ ID MO：12B ΌΜΟΝ32364.seq 、

50 -

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA TCCTGATGGAACGAJ^ACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG GCTGTCGGCACTTAGAAAATGCATCAGGT.VTTGAGGCAATTCTTCGTAA 55 TCTCC^CCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCP>A TCATCATC.^GGCAGGTGACTGGCAAGP>^TTCCGGG^V^A*^CTGACGTTC TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGA^.CCGTCTGGTCC^TCTCTACTATC.^CCCGT CTCCTCCGTCT^AAGAATCTCATAA.\TCTCC^^CATGGCGACTCAGGAC 60 TGTTCTTTCCAACACAGCCCCATCTCCTCCGAC丁丁CGCTGTCAAAATCCG TGAGCTGTCTGACTACCTGCTTC.^AGATTACCCAGTCACCGTGGCCTCCA ACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCA CAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCC；^\GATGC；^AGG CTTGCTGGAGCGCGTGAACACGGAGATA.CACTTTGTCACCAAATGTGCCT 65 TTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC^CATCTCCCGC CTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTG.^AGCCCTGGATCAC TCGCCAG.^.CTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCC SEQ ID NO :12 9 70 pMOMj 2 3^7. seq

GCT.VaCTOCTCTAT^TGATCGATG^\ATTATACATCACTTAA.^GAGACC ACCTAACCCTTTGCTGGACCCG^C.^CCTC.^TTCTG^GACATGGATA TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCJVTTCGTAAGG 75 GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA

O:\92\92747.DOC -138- 200413407 TCTCCAACCATGTCT'GCCCTCTGCCAC.GGCCGCACCCTCT'CGACATCCAA TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC TATCTGGTTACCCTTGAGC.^GCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTG^CCGTCTGGTCCAATCTCTACTATCAACCCGT 5 CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCAACCCAGGAC TGCTCTTTTC^.CACAGCCCCATCTCCTCCGACTTCGCTGTC.^AAATCCG TGAGCTGTCTGACTACCTGCTTC.^GATTACCCAGTCACCGTGGCCTCCA ACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCA CAGCGCT.GGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGG i〇 CTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACC.\AATGTGCCT TTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC.^CATCTCCCGC CTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGA.AGCCCTGGATCAC TCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCT CAACCCTG 5Ξ〇 ID MO:130 15 ' pMON323 92.seq GCCACTCAGGACTGCTCCTTCC^.CACAGCCCCATCTCCTCCGACTTCGC 20 TGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCA.^GATTACCCAGTCA CCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGG CTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC^-AGACTGTCGCTGGGTC CAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCA CCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC 25 AACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAA GCCCTGGATCACTCGCCAGA.ACTTCTCCCGGTGCCTGGAGCTGCAGTGTC AGCCCTACGTAGAGGGCGGTGCtAGGCTCCCCGGGTGAACCGTCTGGTCCA ATCfCTACTATC^CCCGTCTCCTCCGTCT.^AAGAATCTCATAAATCTCC AA^.CATGGCTAACTGCTCTAT.^TGATCGATGAAATTATACATCACTTAA 30 AGAGACCACCT^CCCTTTGCTGGACCCGAAC^CCTCAATTCTGAAGAC ATGGATATCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCiVTT CGTAAGGGCTGTCAAGCACTTAGA^u\ATGCATCAGGTATTGAGGCA.^TTC TTCGTAATCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGA CATCCAATCATCiVTC.^AGGCAGGT'GACTGGCAAGAATT'CCGGGAAAAACT 35 C-ACGTTCTATCTGGTTACCCTTGAGC^GCGCAGGAAC.^ACAG SEQ ID MO: 131 PMON32252.seq 40 GCT^CTGCTCTATAATGATCGATGAAATTATACATCACTT.^AAGAGACC ACCTAACCCTTTGCTGGACCCGAAC*\ACCTCAATTCTGAAGACP%TGGATA TCCTGATGGAACGAAACCTTCGPACTCCP>AACCTGCTCGCATTCGTAAGG GCTGTC^GCACTTAGAA.^TGCATCAGGTATTGAGGCAATTCTTCGTA^. TCTCC.\ACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCC^ 45 TCATCATCAAGGCAGGTGACTGGCAAG^-ATTCCGGGPL^AAACTGACGTTC TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT CTCCTCCGTCTAAAGAATCTCATAAATCTCCCAACATGGCCGACGAGGAG CTCTGCGGGGGCCTCTGGCGGCTGGTCqTGGCACAGCGCTGGATGGAGCG 50 GCTC*\AGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGA ACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGC TGTCTTCGCTTCGTCCAGACC.\ACATCTCCCGCCTCCTGCAGGAGACCTC CGAGCAGCTGGTGGCGCTG.\AGCCCTGGATCACTCGCCAG^CTTCTCCC GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTC^CCCTGTCAGGCGGT 55 .^CGGCAGTGGAGGT^TGGCACCCAGGACTGCTCCTTCC^CACAGCCC CATCTCCTCCGACTTCGCTGTC^A^.TCCGTGAGCTGTCTGACTACCTGC TTC；\.\GATTACCCAGTCACCC-TGGCCTCCAACCTGCAG SEQ ID MO: 132 60 DMON32353.seq

GCT^CTGCTCTATAATGATCGATG^AATTATACATCACTTAAAGAGACC ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA' TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG 65 GCTGTCAAGCPvCTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA TCTCC^CCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCC.^A TCAT'C.VTCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC TATCTGGTTACCCTTGAGCAr\GCGCAGG.\ACA.\CAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGP^ACCGTCTGGTCC^TCTCTACTATCA.^CCCGT

70 CTCCTCCGTCT.VvAGAATCTCAT.-^nTCTCC.V^CATOOCCGnCGAGGnG CTCTGCCGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCG GCTCAAGACTGTCGCTGGGTCC.'^GATGC^\GGCTTGCTGGAGCGCGTGA ACACGGAGATACACTTTGTCACC.^^TGTGCCTTTCAGCCCCCCCCCAGC TGTCTTCGCTTCGTCCAGACC；v\CATCTCCCGCCTCCTGCAGGAGACCTC 75 CGAGC,\GC7GCTCGCGCTGA.AGCCCTGGATCACTCGCCAGAACTTCTCCC 139-

O:\92\92747.DOC 200413407

GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTC^CCCTGTCTGGAGGT aacggatccggtggcaatgggagcggcggaaatggaacccaggactgctc CTTCCAVACACAGCCCCATCTCCTCCGACTTCGCTGTCAA.\ATCCGTGAGC TGTCTGACTACCTGCTTC.\AGATTACCCAGTCACCGTGGCCTCC.^ACCTG CAG 3SQ 10 NO：133 PMOM32354.seq

l〇 GCT.V-vCTGCTCTAT.^ATGATCGATG.^AATTATACATCACTTAAAGAGACC ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA TCCTGATGGAACGAAACCT'TCGAACTCCAAACCTGCTCGCAT'TCGTAAGG GCTGTCAAGCACTTAGA.-\AATGCATCAGGTATTGAGGC.\ATTCTTCGT.^A TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA 15 TCATCATCAAGGCAGGTGACTGGC.^GAATTCCGGGAAAAACTGACGTTC TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCT'CTACT.VTCAACCCG丁 CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCTCCAAGATG CAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATG 20 TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCT CCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGG ATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGA CTCCTCAACCCTGTCTGGCGGCAACGGCACGCAGGACTGCTCCTTCCAAC ACAGCCCCATCTCCTCCGACTTCGCTGTC*\AAATCCGTGAGCTGTCTGAC 25 TACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGA GGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGG AGCGGCTCAAGACTGTCGCTGGG SEQ ID MO:134 30 ΌΜΟΝ32355.seq

GCTAACTGCTCTAT^TGATCGATG^^ATTATACATCACTT^^AGAGACC ACCT^ACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG 35 GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCC^ TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC TATCTGGTTACCCTTGAGCiJVGCGCAGGAACA^.CAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT 40 CrTCCrTCCGTCTTAAAGAAT1CrrCATAAATCTCCAAACAfrGGCCTCCAAGAl'G C^GGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCiAATG TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCT CCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGG ATCACTCGCCAG^CTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGA 45 CTCCTCAACCCTGTCTGGAGGTAACGGATCCGGAGGTTAATGGCACCCAGG ACTGCTCCTTCC^ACACAGCCCCATCTCCTCCGACTTCGCTGTC^AAATC CGTGAGCTGTCTGACTACCTGCTTC^GATTACCCAGTCACCGTGGCCTC CAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGG CACAGCGCTGGATGGAGCGGCTCP.AGAi：TGTCGCTGGG SEQ ID MO: 13 5 P-MOM3 23 56 .seq

GCTA^.CTGCTCTAT^TGATCGATGA.^TTATACATCACTT>^GAGACC 55 ACCTiJ\CCCTTTGCTGGACCCGA.-\C^CCTCA.^TTCTGA.^GACATGGATA •TCCTGATGGAACGAAACCTT'CGAACTCCAAACCTGCTCGCATTCGTAAGG GCTGTCAAGCP'CTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA TCTCC^.CCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCC.\A TCATCATCA^.GGCAGGTGACTGGCAAG^.TTCCGGGAA.^^.CTGACGTTC 60 TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT CTCCTCCGT'CT'AAAGP'-ATCTCATAAATCTCCAAACATGGCCTCCAAGATG CAAGGCTTGCTGGAGCGCGTG.^ACACGGAGATACACTTTGTCACC.\AATG TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCA.\CATCT 65 CCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGG ATCACTCGCCAG^CTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGA CTCCT'CAACCC丁 G 丁 CTGGAGGTAACGGAT'CCGGTGGCAATGGGAGCGGCG GAAr\TGG^CCCAGGACTGCTCCTTCC.\ACACAGCCCCATCTCCTCCGAC TTCGCTGTC.V^XATCCGTGAGCTGTCTGACTACCTOCTTC.-^OnTTACCC 70 AGTCACCC；丁GGCCTCCAACCTOCAGGACGAGGAGCTCTGCGGGGGCCTCT GGCCGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC^-XGACTGTCGCT GGG IO MO：136 75 〇MOM3 ^3 57 .seq

O:\92\92747.DOC -140- 200413407 GCTA.^CTGCTCTATAATGATCGATGA.\ATTATACATCACTm\AGAGACC ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA TCCTGAtGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG 5 GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA TCTCC.^ACCATGTCTGvCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA TCATCATCAAGGCAGGTGACTGGC^GA.^TTCCGGGAAA.\ACTGACGTTC TATCTGGTTACCCTTGAGC.^AGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTG.^ACCGTCTGGTCCAATCTCTACTATC*\ACCCGT I〇 CTCCTCCGTCTAAAGAATCTC.VTAAATCTCCAAACATGGCCCCCCCCAGC TGTCTTCGCTTCGTCCAGACCA.\CATCTCCCGCCTCCTGCAGGAGACCTC CGAGCAGCTGGTGGCGCTGA.\GCCCTGGATCACTCGCCAG^CTTCTCCC GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCA.\CCCTGTCTGGCGGC .AACGGCACGCAGGACTGCTCCTTCC^ACACAGCCCCATCTCCTCCGACTT 15 CGCTGTCAAA.^TCCGTGAGCTGTCTGACTACCTGCTTC.\AGATTACCCAG TCACCGTGGCCTCC^CCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGG CGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC.^GACTGTCGCTGG GTCCAAGATGCAAGGCTTGCTGGAGCGCGTCAACACGGAGATACACTTTG TCACCAAATGTGCCTTTCAGCCC 5EQ ID MO:137 20 pMON3 2 3 5 3.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTT.\^J\GAGACC 25 ACCT^CCCTTTGCTGGACCCGAACAACCTC.^TTCTGAAGACATGGATA TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG GCTGTCMGCACTTAC-AAAATGCATCAGGTATTGApGCAATTCTTCGTAA TCTCCAA.CCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAi^AACTGACGTTC 30 TATCTGGTTACCCTTGAGC^GCGCAGGAAC.^CAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT CTCCTCCGTCT^aAGA^.TCTCAT^\TCTCC^AACATGGCCCCCCCCAGC TGTCTTCGCTTCGTCCAGACCP.-ACATCTCCCGCCTCCTGCAGGAGACCTC CGAGCAGCTGGTGGCGCTGA.iGCCCTGGATCACTCGCCAGAACTTCTCCC 35 GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTC.^ACCCTGTCAGGCGGT AACGGCAGTGGAGGTA^.TGGCACCCAGGACTGCTCCTTCCA^.CACAGCCC CATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGC TTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTC TGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCT 40 CAAGACTGTCGCTGGGTCC^GATGCAAGGCTTGCTGGAGCGCGTGAACA CGGAGATACACTTTGTCACCAA^.TGTGCCTTTCAGCCC SEQ ID NO:133 45 OM0N32359.seq 50 55 60

GCTAACTGCTCTATAATGATCGATGAAAT'TATACATCACTTAAAGAGACC ACCT.^CCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA TCCTGATGGMCGA^CC 丁 TCGAACTCC 丄AACCTGCTCGCATTCGTAAGG GCTGTC.^GCACTTAG^V-uHTGCATCAOGTATTGAGGCAATTCTTCGT.\A TCTCC^CCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGPvCGTTC TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCOTCTOGTCCAATCTCTACTPvTCAACCCGT CTCCTCCGTCTAJ^GAA.TCTCATAAATCT'CCAAACATGGCCCCCCCCAGC TGTCTTCGCTTCGTCCAGACC^CATCTCCCGCCTCCTGCAGvGAGACCTC ' 广/-'ί、 ^ r-n m p /<"-· rri/-' 、rp ' 广 rp r-» /—1 〇 .一、广、^ m m ^i 〇、一 λ * οόΛ i，一一九 ‘ U一一乂όγάΙ i -、一〜·“ GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCX\CCCTGTCTGGAGGT AACGGCAGTGGTGGC.V.TGGGAGCGGCGGA^ATGG^CCCAGGACTGCTC CTTCC^-.CACAGCCCCATCTCCTCCGACTTCGCTGTC^^AATCCGTGAGC TGTCTGACTACCTGCTTC^GATTACCCAGTCACCGTGGCCTCC^CCTG CAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCG

65 CTGGATGGAGCGGCTCAAGACTGTCGCTCGGTCCAAGATGCAAGGCTTGC TGGAGCGCGTGA.\CACGGAGATACACTTTGTCACC*-A^.TGTGCCTTTCAG CCC SEQ ID MO:139 pM0N3：360.3eq

GCTAACTGCTCTATA.Vr〇ATCGATG.V^TTAT?^ATCACTT^AAGAGACvC

70 ACCT,^ACCCTTTGCTGCACCCG^C^\CCTC.\ATTCTC.^.GACATGGATA TCC丁GATGG.WCGAAACCTTCGAACTCCAAACCTGC丁CGCATTCGTAAGG GCTCTC.^-XGCACTTAGr-vAAATGCATCAGGTATTGAGGCAATTCTTCGT^ TC T C C ；V%C C ATGT C TGC C C T CTG C C ACGG C CGC AC C CTCTC GAC ATC C ；vA TCATCA 丁 C.-VAGGCAGGTGACTGGCAAGAATTCCCiGGAAAAACTGACGTTC 75 TATCTGGTTACCCTTGAGC.^GCGCAGG^C^CAGTACGTAGAGGGCGG 141 -

O:\92\92747.DOC 200413407

TGGAGGCTCCCCGGGTCA.^CCGTCTGGTCC.^ATCTCTACTATCAACCCGT CTCCTCCGTCTAAAGAATCTCATAAA.TCTCCCAACATGGCCGACGAGGAG CTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCG GCTCAAOACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGA 5 ACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGC TGTCTTCGCTTCGTCCAGACC.AACATCTCCCGCCTCCTGCAGGAGACCTC CGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCC GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTC^CCCTGTCTGGAGGT AGTGGATCCGGAGGTTCTGGCACCCAGGACTGCTCCTTCC^.CACAGCCC i〇 CATCTCCTCCGACTTCGCTGTCA.\AATCCGTGAGCTGTCTGACTACCTGC TTC.^AGATTACCCAGTCACCGTGGCCTCCAACCTGCAG SEQ ID NO: 140 PMON32362.seq 15

GCTAACTGCTCTATAATGATCGATGAAATT.VTACATCACTTAAAGAGACC ACCT'AACCCTT'TGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG GCTGTCAAGCACTTAGAAAATGCATCAC-GTATTGAGGCAATTCTTCGTAA 20 TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCA^. TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCGACGAGGAG 25 CTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCG gctcaagactgtcgctgggtccaagatgcaaggcttgctggagcgcgtga ACACGGAGATACACTTTGTCACC.^AATGTGCCTTTCAGCCCCCCCCCAGC TGTCTTCGCTTCGTCCAGACC.^ACATCTCCCGCCTCCTGCAGGAGACCTC CGAGCAGCTGGTGGCGCTG^GCCCTGGATCACTCGCCAG^CTTCTCCC 30 GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCA.\CCCTGTCTGGAGGT AGTGGATCCGGTGGCAGTGGGAGCGGCGGATCTGG^CCCAGGACTGCTC CTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAA.^\TCCGTGAGC TGTCTGACTACCTGCTTC.\AGATTACCCAGTCACCGTGGCCTCC；aCCTG CAG SEQ ID NO:141 35 PMCN32393.seq

GCCACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGC 40 TGTCA.\AATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCA CCGTGGCCTCC.\ACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGG CTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC^GACTGTCGCTGGGTC CAAGATGC.^GGCTTGCTGGAGCGCGTGA^.CACGGAGATACACTTTGTCA CCA^^TGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC 45 AACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAA GCCCTGGATCACTCGCCAGA.^CTTCTCCCGGTGCCTGGAGCTGCAGTGTC AGCCCGACTCCTCAACCCTGTACGTAGAGGGCGGTGGAGGCTCCCCGGGT G^CCGTCTGGTCC^TCTCTACTATCAACCCGTCTCCTCCGTCTAA^.GA ATCT'CATA^JVTCTCCAAACATGGCTAACTGCTCT'A.TAATGATCGATGAAA 50 TTATACATCACTT.^vAAGAGACCACCT^CCCTTTGCTGGACCCG^C^C CTC^TTCTG.^AGACATGGATATCCTGATGG^CGA^CCTTCGAACTCC AAACCTGCTCGCATTCGTAAGGGCTGTCAAGCACTTAGAAAATGCATCAG GTATTGAGGC^TTCTTCGT.^.TCTCCAACCATGTCTGCCCTCTGCCACG 55 •VTTCCGGGAAAAACTGACGTTCTWTCTCCACCCTTGAGCAAGCGCAGG AACAACAG SEQ ID NO: 142 60

ΌΜΟΜ3227：.seq 65 70 75

GCT^CTGCTCTATAATGATCGATG.\A.^TTATACATCACTTA.^GAGACC ACCTPvACCCTTTGCTGGACCCGPu^C^CCTC.^ATTCTG^GACATGGATA TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG GCTGTCAAGCACTTAGAAAATGC.VrCAGGT.VTTGAGGCAATTCTTCGTAA TCTCC.\ACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA TCATCATC.^GGCAGGTGACTGGC^GAATTCCGGGAAA.\^.CTGACGTTC TATCTGGTTACCCTTG；^GC^GCGCAGG^CA.^CAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTv^.^CCGTCTGGTCC^TCTCTACTATC^CCCGT CTCCTCCGTCTA.\AG^TCTCAT.\.WTCTCC.W^CATGGCCGACGAGGAG CTCTGCCGGGCCCTCTGGCGGCTGGTCCTGCCACAGCGCTCGATGGAGCG GCTCAAGACTGTCGCTGGGTCC^GATGC^GGCTTGCTGGAGCGCGTGA ACACGGACATACACTTTGTCACC.\.-^TGTGCCTTTCAGCCCCCCCCCAGC TGTCTTCGCTTCGTCCAGACC^CATCTCCCGCCTCCTGCAGGAGACCTC CGAGCAGCTGGTGGCGCTGP'.AGvTCCTGGATCACTCGCCAG.^ACTTCTCCC GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTC.^CCCTGGGCGGTGGA

O:\92\92747.DOC 142- 200413407 TCCGGAGGTACCCAGGACTGCTCCTTCC.\ACACAGCCCCATCTCCTCCGA CTTCGCTGTC.\AAATCCGTGAGCTGTCTGACTACCTGCTTC.\AGATTACC CAGTCACCGTGGCCTCCAACCTGCAG 3EQ ID NO:143 OM0M32372.seq

GCTAACT'GCTCTATAATGATCGAT'GAAATTATACATCACTTAAAGAGACC ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA 10 TCCT'GATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG GCTGTdCACTTPvGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA TCATCATCAAGGCAGGTGACTGGCAAGAArrCCGGGAAAAACTCACGTTC TATCTGGTTACCCTTGAGC.^AGCGCAGGAAC^ACAGTACGTAGAGGGCGG 15 TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATC^CCCGT CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCGACGAGGAG CTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCG GCTC.^GACTGTCGCTGGGTCCA^.GATGCAAGGCTTGCTGGAGCGCGTGA ACACGGAGATACACTTTGTCACCA^^ATGTGCCTTTCAGCCCCCCCCCAGC 20 TGTCTTCGCTTCGTCCAGACCA.^CATCTCCCGCCTCCTGCAGGAGACCTC CGAGCAGCTGGTGGCGCTG^.GCCCTGGATCACTCGCCAGAACTTCTCCC GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTC^J\CCCTGGGCGGTGGA TCCGGAGGTGGCACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTC CGACTTCGCTGTCAAAATCCGTGAGCT'GTCTGACTACCTGCTTCAAGATT 25 ACCCAGTCACCGTGGCCTCCAACCTGCAG SEQ ID NO：144 pMON3 2 3 7 3.seq 30 GCTAACTGCTCTAT^J\TGATCGATGAAATTATACATCACTTAAAGAGACC ACCTAACCCTTTGCTGGACCCGAAC.\ACCTCAATTCTGAAGACATGGATA TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG GCTGTC^GCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCC.^ 35 TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC TATCTGGTTACCCTTGAGC*\AGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCT'CTACTAT'CAACCCGT CTCCTCCGTCTAAAGAATCT'CATAAATCTCCAAACATGGCCGACGAGGAG CTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCG 40 GCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCT'TGCTGGAGCGCGTGA ACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGvCCCCCCCCCAGC TGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTC CGAGCAGCTGGTGGCGCTGAAGCCCTGGA.TCACTCGCCAGAACTTCT'CCC GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTC^.CCCTGGGCGGTGGG 45 TCAGGAGGTGGATCCGGAGGTACCCAGGACTGCTCCTTCC^CACAGCCC CATCTCCTCCGACTTCGCTGTC^JivATCCGTGAGCTGTCTGACTACCTGC TTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAG SEQ ID NO: 145

50 pMON3 237 4.seq GCT^CTGCTCTATAATGATCGATGA^^\TTATACATCACTT^\AGAGACC ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCT'CGCAT'TCGTAAGG 55 GCTGTC.\.\GCACTTAGAAA.\TGCATCAGGTATTGAGG(：AATTv/：TTCGT^-A TCTCC.\ACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCC>A TCATCATCAAGGCAGGTGACT'GGCAAGAA.TTCCGGGAAAAACm'CGTTC TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTG.^CCGTCTGGTCCAATCTCTACTATCAACCCGT 60 CTCCTCCC/TCTAAAGAATCTCATAAATCTCCAAACATGGCCGACGAGGAG CTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCG GCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGA ACACGGAGATACACTTTGTCACC^^ATGTGCCTTTCAGCCCCCCCCCAGC TGTCTTCGCTTCGTCCAGACC.VvCATCTCCCGCCTCCTGCAGGAGACCTC 65 CGAGCAGCTGGTGGCGCTGPu^GCCCTGGATCACTCGCCAGPu-.CTTCTCCC GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCP^CCCTGGGCGGTGGA TCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCPx ACACAGCCCCATCTCCTCCGACTTCGCTGTCAA.^TCCGTGAGCTGTCTG ACTACCTGCTTC^GATTACCCAGTCACCGTGGCCTCC^CCTGCAG SSQ ID NO: 14 6 70 ' OMCN32375.〇eq

GCTAACTGCTCT'ATAATGATCGATGAAATTATACATCACT'TAPvAGAGACC 75 ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA

O:\92\92747.DOC 143 - 200413407 TCCTGATGGAACGAAACCTTCGAACTCCAi;\ACCTGCTCGCATTCGT.^AGG GCTGTC^GCACTTAGA.^AATGCATCAGGT.\TTGAGGCAATTCTTCGTAA TCTCC.^ACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC 5 TATCTGGTTACCCTTGAGCAAGCGCAGGAAC.^ACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCT'ACTATCAACCCGT CTCCTCCGTCTAAAGAATCTCATPu\ATCTCC^\ACATGGCCGACGAGGAG CTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCG GCTCAAGACTGTCGC丁GGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGA 10 ACACGGAGATACACTTTGTCACCA.\ATGTGCCTTTCAGCCCCCCCCCAGC TGTCTTCGCTTCGTCCAGACC.^ACATCTCCCGCCTCCTGCAGGAGACCTC CGAGCAGCTGGTGGCGCTGPu^GCCCTGGATCACTCGCCAGAACTTCTCCC GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTC^CCCTGGGCGGTGGG TCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCACCCAGGACTGCTC 15 CTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGC TGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTG CAG 3EQ ID NO:147 20 OM0N32376.seq

GCTA^.CTGCTCTAT^TGATCGATGPu\ATTATACATCACTT.AA.\GAGACC ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG 25 GCTGTC.\AGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGT^A TCTCC.\ACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCC.^vA TCATCATCAAGGCAC-GTGACTGGCAAGAA.TTCCGGGAAAAACTGACGTTC TATCTGGTTACCCTTGAGC.aAGCGCAGGA^.C^CAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT 30 CTCCTCCGTCT.-^G^TCTCATAAATCTCC.\AACATGGCCGACGAGGAG CTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCG GCTCAAGACTGTCGCTGGGTCC^J\GATGCAAGGCTTGCTGGAGCGCGTGA ACACGGAGATACACTTTGTCACCA.^.TGTGCCTTTCAGCCCCCCCCCAGC TGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTC 35 CGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGA.^CTTCTCCC GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTC^CCCTGGGCGGTGGG TCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTCAGGGGGAGGTAG TGGTACCCAGGACTGCTCCTTCC^CACAGCCCCATCTCCTCCGACTTCG CTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTC^AGATTACCCAGTC 40 ACCGTGGCCTCCAACCTGCAG SEQ ID MC:143 PMON22373.seq 45 50 60 GCT^CTGCTCTAT^-XTGATCGATGAAATTATACATCP^CTT.^^AGAGACC ACCTAACCCT丁T'GCT'GGACCCGAACAACC.rCAATTCTGAAGACATGGATA TCCTGATGG^CG^*ACCTTCGAACTCCAA.\CCTGCTCGCATTCGTAAGG GCTGTC.\AGCACTTAG^AA.\TGCATCAGGTATTGAGGC^.TTCTTCGT^. TCTCCAACCATGTCTGCCCTCTGCCACQGCCGCACCCTCTCGACATCCA.\ TATCTGGTTACCCTTGAGC^GCGCAGGA.\C.\r\CAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGG 丁 CCAATCTCTACTATCAACCCC-T： CTCCTCCGTCT.\AAG^TCTCAT^-\TCTCCAA^.CATGGCCTCCA^.GATG CAAGGCTTGCTGGAGCGCGTGP^CACGGAGATACACTTTGTCACC.W.TG TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC^CATCT CCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGA-^GCCCTGG ATCACTCGCCAGA.^CTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGA i L- i ^ ^ ^ i -^LjUL. oo i (ο1ο/λ I ^ i L oL. 1 ^ j. ^ ^ AjaCACAGCC^CATCTCCTCCGP-,CTTCGCTGTC^V\ATCCGTGAGCTGTCT GACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGA CGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGA TGGAGCGGCTC^GACTGTCGCTGGG SEQ 10 MO: 149

65 OM0M32379.seq

GCT^CTGCTCTAT,\ATGATCGATG；^TTATACATCACTT.\P^AGAGACC ACCTA^CCCTTTGCTGQACCCG^C^CCTCPvATTCTGAAGACATGGATA TCCTG；vTGG.^CG；^ACCTTCG^\CTCC^^ACCTGCTCGCATTCGT*\AGG 70 GCTGTC；aGCACTTAG^AATGCATCAGCTATTCAGCC^TTCTTCGT.^ TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA TCATCATC；^GGCAGGTGACTGGC.\AGA.ATTCCGGGAA--W\CTGACGTTC TATCTC-GTTACCCTTGAGC.\.-\GCGCAGG；^AC；^CAGTACGTAGAGGGCGG TGGAGGCTCCCCCGGTGA.^CCGTCTGGTCC.^TCTCTACTATC.\ACCCGT 75 CT'CCTCCGTCTAAAGAATCTCZAITAAATCTCCAAACATGGCCTCCAAGAT'G

O:\92\92747.DOC -144- 200413407 CAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACC.^ATG TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC^CATCT CCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGG ATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGA CTCCTCA.^CCCTGGGCGGTGGATCCGGAGGTGGCACCCAGGACTGCTCCT TCCAACACAGCCCCATCTCCTCCGACTTCGCTGTC^^TCCGTGAGCTG TCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCA GGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCT GGATGGAGCGGCTCAAGACTGTCGCTGGG SEQ ID NO :15 0 ΌΜΟΝ32330.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC 15 ACCTAACCCTTTGCTGGACCCGAAC.\ACCTCAATTCTO^GACATGGATA TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA TCTCC^CCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCC^ TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAA.\ACTGACGTTC 20 TATCTGGTTACCCTTGAGC^.GCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCTCCAAGATG CAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATG TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC.\ACATCT 25 CCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGG ATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGA CTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGATCCGGAGGTACCCAGG ACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTC^^AATC CGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTC 30 CAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGG CACAGCGCTGGATGGAGCGGCTCA^.GACTGTCGCTGGG SEQ ID MO： 151 PMON32231.3eq 35

GCTAACTGCTCTAT^-ATGATCGATGAAATTATACATCACTTA^GAGACC ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTG^GACATGGATA TCCTGATGGA^CGAA.ACCTTCGAACTCCAAACCTGCTCGCATTCGT*\AGG GCTGTCAAGCACTTAC'\AAATGCATCAGGTATTGAGGCAATTCTTCGTAA 40 TCTCC*\ACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCC^ TCAT'CATC^\AGGCAGGTGACrrGGCAAGAATTCCGGGAAAA^\CTGACGTTC TATCTGGTTACCCTTGAGCA^.GCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACT'AT'CAACCCG丁 CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCTCCAAGATG 45 CAAGPCTTGCTC-GAGCGCGTGAACACGGAGATACACTT'TGT'CACCAAATG TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCA-^CATCT CCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTG.\AGCCCTGG ATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGA CTCCTCA^.CCCTGGGCGGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTG 50 GTACCCAGGACTGCTCCTTCC.\.\CACAGCCCCATCTCCTCCGACTTCGCT GTCAAAATCCGTGAGCT'GTCTGACTACCTGCTTCAAGATTACCCAGTCAC CGTGGCCTCC^CCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGC TGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAP.GACTGTCGCTGGG SEQ ID MO:152 一 cMON3 2 2 32.seq

GCT^CTCCTCTAT^TGATCGATGA^ATTATACATCACTT^^GAGACC ACCTAACCCTTT'GCT'GGACCCGAACAACCTCAATTCTGAAGACATGGATA 60 TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCT'CGCATTCGTAAGG GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATl'CTTCGTAA TCTCC；^CCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAPy TCATCATCAAGGCAGGTGPvCTGGCAAGAATTCCGGGAAAAACTGACGTTC TATCTGGTTACCCTTGAGCAAGCGCAGGAAC^CAGTACGTAGAGGGCGG 65 TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCT'CTACTATCAACCCGT CT'CCT'CCGTCT'AAAGP^ATCTCATAAATCTCCAAACATGGCCTCCAAGATG CAAGGCTTGCTGGAGCGCGTGAACACGGPvGATACACTTTGT'CACCAAATG TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC^CATCT CCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTG.\AGCCCTGG 70 ATCACTCGCCAG；^CTTCTCCCCGTCCCTGGAGCTGCAGTGTCAGCCCGA CTCCTC\-ACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCG GAGGTGGCACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGAC TTCGCTGTC,\.^^\TCCGTGAGCTGTCTGACTACCTGCTTC.^GATTACCC AGTCACCGTGGCCTCC^CCTGCAGGACGAGGAGCTCTGCGGGGGCCTCT 75 CGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCr-uAGACTGTCGCT

O:\92\92747.DOC -145- 200413407 GGG SEQ ID MO：153 10 15 20 25 PMON32333.seq GCT^CTGCTCTAT.\ATGATCGATGAAATTATACATCACTTAAAGAGACC ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA TCTCCAACCATGTCTGCCCl'CTGCCACGGCCGCACCCTCTCGACATCCAA TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC TATCTGGTTACCCTTGAGC.\AGCGCAGGAAC.\ACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATC^CCCGT CTCCTCCGTCTAAAGAATCTCAT.^^ATCTCC^AACATGGCCTCCAAGATG C.\AGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATG TGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCT CCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGG ATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGA CTCCTC.^CCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCG GAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACAC AGCCCCATCTCCTCCGACTTCGCTGTC.\AAATCCGTGAGCTGTCTGACTA CCTGCTTC^GATTACCCAGTCACCGTGGCCTCCAP'.CCTGCAGGACGAGG AGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAG CGGCTCAAGACTGTCGCTGGG SEQ ID NO :154 CMON3 23 3 4 . seq

GCT^ACTGCTCTATA-ATGATCGATGAAATTATACATCACTTAAAGAGACC 30 ACCTAACCCTTTGCTGGACCCGPu^CAACCTCAATTCTGAAGACATGGATA TCCTGATGGA.\CGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA TCTCC^CCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAA.\AACTGACGTTC 35 TATCTGGTTACCCTTGAGCAAGCGCAGGAAC^-ACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGA.\CCGTCTGGTCC^-ATCTCTACTATCAACCCGT CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCCCCCCCAGC TGTCTTCGCTTCGTCCAGACC^JVCATCTCCCGCCTCCTGCAGGAGACCTC CGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCC 40 GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGA TCCGGAGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGA CTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACC CAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTC 45 TGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACT TTGTCACCAAATGTGCCTTTCAGCCC SEQ ID NO:155

pMON3 2 3 3 5.seq > 50 GCTAACTGCT'CTAT'AATGATCGATGAAATTATPvCATCACTTAAAGAGACC ACCTAACCCTTTGCTGGACCCGA^.CAACCTCAATTCTGAAGACATGGATA TCCTGAT'GGAACGAAACCTTCGAACTCCAAACCTC.CTCGCATTCGTAAGG GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTTCTTCGTAA 55 TCTCCAACC.VTGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA TCATCATCAAGGCAGGTGACTCGCAAGAATTCCGGGAAAAACTGACGTTC TATCTGGTTACCCTTGAGCAAGCGCAGGAAC.nACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTG^CCGTCTGGTCC.^TCTCTACTATC^CCCGT CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCCCCCrCCAGC 60 TGTCTTCGCTTCGTCCAGACC*\ACATCTCCCGCCTCCTGCAGGAGACCTC CGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCC GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTC.-JXCCCTGGGCGGTGGA TCCGGAGGTGGCACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTC CGACTTCGCTGT'CAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATT 65 ACCCAGTCACCGTGGCCTCC.\.-.CCTGCAGGATGAGGAGCTCTGCGGGGGC CTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCA.^GACTGT CGCTGGGTCCAAGATGC.^GGCTTCCTGGAGCGCGTG^CACGGAGATAC ACTTTGTCACC^\TGTGCCTTTCAGCCC SEQ ID NO： 15 6 70 pMOM3 Z 3 n 6.seq

GCT'AACTGCTCTATAATGATCGATGAAATTATAC.VTCACTTAAAGAGACC ACCT.\ACCCTTTGCTGGACCCG^ACAACCTC.^TTCTGAAGACATGGATA 75 TCCTGATGGPvACGAAACCTTCGAACTCC.\AACCTGCTCGCATTCGT.\AGG

O:\92\92747.DOC 146- 200413407 GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC TATCTGGTTACCCTTGAGC^GCGCAGGAACAACAGTACGTAGAGGGCGG 5 TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT CTCC丁CCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCCCCCCCAGC TGTCTTCGCTTCGTCCAGACCPuACATCTCCCGCCTCCTGCAGGAGACCTC CGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCC GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCA.^CCCTGGGCGGTGGG 10 TCAGGAGGTGGATCCGGAGGTACCCAGGACTGCTCCTTCC^CACAGCCC CATCTCCT'CCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGC TTCA.^GATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTC TGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCT CAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACA 15 CGGAGATACACTTTGTCACC.\AATGTGCCTTTCAGCCC SEQ ID MO:157 PMOM32337.seq

20 GCTA^.CTGCTCTATiATGATCGATGAAATTATACATCACTTAAAGAGACC ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA TCCTGATGGA^.CGAAACC丁TCGAACT'CCAAACCTGCTCGCAT'TCGTAAGG GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA TCTCC^CCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA 25 TCATCATCA^.GGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC TATCTGGTTACCCTTGAGCA^.GCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCC.^\TCTCTACTATC.\ACCCGT CTCCTCCGT'CTAAAGAATCTCATAAATCTCCAAACATGGCCCCCCCCAGC TGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTC 30 CGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCC GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTC^-ACCCTGGGCGGTGGA TCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCA ACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAJ^TCCGTGAGCTGTCTG ACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGAC 35 GAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGAT GGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGC.^GGCTTGCTGGAGC GCGTG^CACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCC SEQ ID MO: 158 40 pMON323S8.seq 45 50 55 60 GCTA.ACTGCTCTAT^TGATCGATGAAATTATACATCACTT.\AAGAGACC ACCT^.CCCTTTGCTGGACCCGAACAACCTCAATTCTGA^GACATGGATA TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATITCGTAAGG GCTGTC^GCACTTAGAAAATGCATCAGGTATTGAGGC.^ATTCTTCGT^ TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCC^A TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAA^ACTGACGTTC TATCTGGTTACCCTTGAGCA.\GCGCAGGAACAACAGTACGTAGAGGGCGG 'TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAJ^CATGGCCCCCCCCAGC TGTCTTCGCTTCGTCCAGACCA.\CATCTCCCGCCTCCTGCAGGAGACCTC CGAGCAGCTGGTGGCGCTC^GCCCTGGATCACTCGCCAG.\ACTTCTCCC GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTC^CCCTGGGCGGTGGG 广、广 θ、一，一 m rp rrp /> 一，、、r*n 广 r θ r,一广，' Ρ L V— i. O L 'w L Ο ίΛ. O VJ ίΛ'Ο'ν-Ι i i. v«7 i. V— CTTCC^.CACAGCCCCATCTCCTCCGACTTCGCTGTC^^TCCGTGAGC TGTCTGACTACCTGCTTC^.GATTACCCAGTCACCGTGGCCTCC.\ACCTG CAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCG TGGAGCGCGTG^CACGGAGATACACTTTGTCACC^^ATGTGCCTTTCPiG CCC SEQ ID MO：IS9

pMON3 2 3 3 9.seq 65 GCTA.-.CTGCTCTAT；^TGATCGATGAAATTATACATCACTT.^^.GAGACC ACCT；^CCCTTTGCTGGACCCGA^.CAACCTC.\ATTCTG；^GACATGGATA TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGC.VITCGTAAGG GCTGTCAAGCACTT.'GAAAATGC.VTCAGGTATTGAGGCAATTCTTCGTAA TCTCC^CCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCC^ 70 tcatcatc.\.^ggcaggtgactggc.\agaattccgggaa.^-.ctgacgttc

TATCTGGTTACCCTTGAGC^GCGCAGGAAC.^CAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATC-\.\CCCGT CTCCTCCGTCT.^^AGAATCTCAT.^^ATCTCC.^^CATGGCCCCCCCCAGC TGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTC 75 CGAGCAGCTGGTGGCGCTC.-\AGCCCTGGATCACTCGCCAGA*ACTTCTCCC

O:\92\92747.DOC -147- 200413407 GGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTC^CCCTGGGCGGTGGG TCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTCAGGGGGAGGTAG TGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCG _ CTGTC.^^AATCCGTGAGCTGTCTGACTACCTGCTTC.^GATTACCCAGTC 5 ACCGTGGCCTCCA.\CCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCG GCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC^GACTGTCGCTGGGT CCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATV\CACTTTGTC ACCAAA.TGTGCCTTTCAGCCC SEQ ID NO :16 0 10 heit3-2329iinki0.seq

GCT^.CTGCTCTAT^TGATCGATGAAATTATACATCACTT.\Pu^GPvGACC ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA 15 TCCTGATGGAACG.\AACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA TCTCC^CCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCC^ TCATCATCAAGGCAGGTGACTGGC.\AGA-^TTCCGGGAAAAACTGACGTTC TATCTGGTTACCCTTGAGCPvAGCGCAGGAAC.\ACAGTACGTAGAGGGCGG 20 TGGAGGC丁ccccgggtgaaccgtctggtccaatctctactXtcaacccgt

CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCGATTACCCA GTCACCGTGGCCTCCA.\CCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTG GCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC.^AGACTGTCGCTG GGTCCAAGATGC^GGCTTGCTGGAGCGCGTGAACACGGAGATACACTTT 25 GTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCA GACC^CATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGC TGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAG TGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGATCCGG AGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCG 30 CTGTCAA.iATCCGTGAGCTGTCTGACTACCTGCTTC.^ SEQ ID NO: 161 hflt3-2329IinkI5.seq

35 GCTAACTGCTCTATAATGATCGATGAAATTJVTACATCACTTAAAGAGACC ACCT^CCCTTTGCTGGACCCGA.\CAACCTCAATTCTG^-AGACATGGATA TCCTGATCGAACa二*AACCTTCGAACTCCAAACCT'GCTCGCATTCGTAAGG GCTGTCAAGCACTTAGAAA^.TGCATCAGGTATTGAGGCAATTCTTCGTAA TCTCC.\ACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA 40 TCATCATCAAGGCAGGTGACTGGCAAGAATTCC.GGGAAAAACTGACGTTC TATCTGGTTACCCTTGAGCAAGCGCAGGAJ\C^-CAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCGATTACCCA GTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTC 45 GCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCA.\GACTGTCGCTG GGTCCAAGATGCA^.GGCTTGCTGGAGCGCGTGAACACGGAGATACACTTT GTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCA GACC^CATCTCCCGCCTCCTGCAGGA^ACCTCCGAGCAGCTGGTGGCGC TGAAGCCCTGGATCACTCGCCAGA^.CTTCTCCCGGTGCCTGGAGCTGCAG 50 TGTCAGCCCGACTCCTC^CCCTGGGCGGTGGGTCAGGAGGTGGGTCAGG AGGTGGPvTCCGGAGGTGGCACCCAGGACTGCTCCTTCC^-CACAGCCCCA TCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTT CAA SEQ ID MC:L62 55 htlt:3-3435iinkl0.3eq GCT^CTGCTC7AT^TGATCGATGA.^.TTATACATCACTT^.AGAGACC ACCT.^CCCTTTGCTGGACCCG^.CAACCTCAATTCTG.^AGACATGGATA 60 TCCTGATGa^ACGAAACCTTCGAACTCCAAACCTGCTCGC.VTTCGTAAGG GCTGTCAAGCACTTAGAAAATGCATCAGGUTTGAGGCAATTCTTCGTAA TCTCC^.CCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCC.\A TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC TATCTGGTTACCCTTGAGC^nGCGCAGG^C^CAGTACGTAGAGGGCGG 65 TGGAGGCTCCCCGGGTG^CCGTCTGGTCCA.^TCTCTACTATCAACCCGT CTCCTCCGTC 丁AAGV.TCTCATAAATCTCCAAACATGGCCGCCTCCAAC CTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACA GCGCTGGATGGAGCGGCTC^-AGACTGTCGCTGC-GTCCPu-\GPvTGC^GGCT TGCTGCAGCGCGTGP*.ACACGGAGATACACTTTGTCACC.\A.-：rGTGCCTTT 70 CAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCT CCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTC GCCAG^CTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCA ACCCTGGGCGGTGGGTCAGGAnGTGGATCCGGAGGT.\CCCAGGACTGCTC CTTCC.^CACAGCCCCATCTCCTCCGACTTCCCTGTC.\AAATCCGTGAGC 75 TGTCTGACTACCTGCTTC.^GATTACCCAGTCACCGTG SEQ ID NO :16 3

O:\92\92747.DOC -148- 200413407 h£it3-3435Lmki5 .seq 5 GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTT.\AAGAGACC ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCT'CGCATTCGTAAGG GCTGTC.^GCACTTAGAAA.ATGCATCAGGTATTGAGGCAATTCTTCGTAA TCTCCAACCA丁GTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA 10 TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC TATCTGGTTACCCTTGAGCAAGCGCAGGAAC*\ACAGTACGTAGAAGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCA^TCTCTACTATCAACCCGT CTCCTCCCrrCTAAAGAATCTCA.TAAATCTCCAAACATGGCCGCCTCCAAC CTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACA 15 GCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCT TGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTT CAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC^CATCTCCCGCCT CCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTG^GCCCTGGATCACTC GCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCA 20 ACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGG CACCCAGGACTGCTCCTTCC^.CACAGCCCCATCTCCTCCGACTTCGCTG TCAAAATCCGTGAGCTGTCTGACTACCTGCTTC.^GATTACCCAGTCACC GTG SEQ ID NO:164 25 hf 1-62β3 iir.klO . seq GCTAACTGCTCTATAATGATCGATG^-AATTATACATCACTTAAAGAGACC ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA 30 TCCTGATGGP«J\CGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG GCTCTC 从 GCACTTAGAAAATGCJVTCAGGTATTGAGGCAATTCTTCGTAA TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAA?u^CTGACGTTC TATCTGGTTACCCTTGAGCA^.GCGCAGG^CAACAGTACGTAGAGGGCGG 35 TGGAGGCTCCCCGGGTG^CCGTCTGGTCCAATCTCTACTATCAACCCGT CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAr\CATGGCCGTCGCTGGG TCCA^.GATGCA_AGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGT CACC.^AATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGA CCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTG 40 AAGCCCTGGATCACTCGCCAG.\ACTTCTCCCGGTGCCTGGAGCTGCAGTG TCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGATCCGGAG GTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCT GTCPvAAATCCGTGAGCTGTCTGACTACCTGCTTC^GATTACCCAGTCAC CGTGGCCTCC^-ACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGC 45 TGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACT SEQ ID MO : 15 5 hflt3-52631in!<15 .seq 50 GCTAACTGCTCTAT'AATGiVTCGATGAAATTATACATCACTTAAAGAGACC ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA TCCTCATGGAACGPlAACCTTCGAACTCCA^vACCTGCTCGCATTCGTAAGG GCTGTCAAGCACTTAGAAAATGCATCAGC/TATTGAGGCAATTCTTCGTAA TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACC.CTCTCGACATCCAA 55 TCATCATCAAGGCAGGT'GACTGGCAAGAATTCCGGGAAAAACTGACGT'TC TATCTGGTTACCCTTGAGC.^GCGCAGG*\AC.^CAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAAT'CTCTACT'ATCAACCCGT CT'CCTCCGTCTAAAGAATCT'CATAAATCTCCAAACATGGCCGTCGCTGGG TCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGT 60 CACC^\.-\TGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGA CCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTG PvAGCCCTGGATCACTCGCCAG.^ACTTCTCCCGGTGCCTGGAGCTGCAGTQ TCAGCCCGACTCCTC；vACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAG GTGGATCCGGAGGTGGCACCCAGGACTGCTCCTTCCA.\CACAGCCCCATC 65 TCCTCCGACTTCGCTGTCAA.^TCCGTGAGCTGTCTGACTACCTGCTTCA AGATTACCCAGTCACCGTGGCCTCC；^CCTGCAGGACGAGGAGCTCTGCG GGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCA-^G ACT SEQ ：D NO :166 70 h f i c 3 - 9 ·! 9 5 1 i n k 10 .seq

GCTAACTGCTCTV'TAATGATCGATGAAATTATUCACTTAAAGAGAC’C ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA 75 TCCTGATCGAACGAAACCTTCGAACTCC.^nACCTGCTCGCATTCGT.^AGG -149-

O:\92\92747.DOC 200413407 GCTGTC^GCACTTAGAAAATGCATCAGGTATTGAGGC.\ATTCTTCGT^ TCTCC.\ACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC • TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG 5 TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCCGCTTCGTC CAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGC GCTG^.GCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGC AGTGTCAGCCCGACTCCTC^CCCTGGGCGGTGGGTCAGGAGGTGGATCC i〇 GGAGGTACCCAGGACTGCTCCTTCCA^.CACAGCCCCATCTCCTCCGACTT CGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTC^GATTACCCAG TCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGG CGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGC丁CAAGACTGTCGCTGG GTCC.-AGATGC*\AGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTG 15 TCACC.\AATGTGCCTTTCAGCCCCCCCCCAGCTGTCTT SEQ ID NO:I67 hflt3^94951inkI5.seq

20 GCT.^CTGCTCTATAATGATCGATGAAATTATACATCACTT^-AAGAGACC ACCT.\ACCCTTTGCTGGACCCGAACA.\CCTCAATTCTGA.^GACATGGATA TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGT'AAGG GCTGTCAAGCACTTAGAAAATGCATCAGGTATTC-AGGCAATTCTTCGTAA TCTCC*\ACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA 25 TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCCGCTTCGTC CAGACCA-ACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGC 30 GCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGvCCTGGAGCTGC AGTGTCAGCCCGACTCCTC^CCCTGGGCGGTGGGTCAGGAGGTGGGTCA GGAGGTGGATCCGGAGGTGGCACCCAGGACTGCTCCTTCCAACACAGCCC CATCTCCTCCGACTTCGCTGTCA^^TCCGTGAGCTGTCTGACTACCTGC TTCAAGATTACCCAGTCACCGTGGCCTCCA^.CCTGCAGGACGAGGAGCTC 35 TGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCT CAAGACTGTCGCTGGGTCC.^GATGCAA.GGCTTGCTGGAGCGCGTGAACA CGGAGATACACTTTGTCACC^^ATGTGCCTTTCAGCCCCCCCCCAGCTGT CTT SSQ ID NO:163 40 hfit;3-9399iiaki0 .seq 45

GCT^CTGCTCTAT.^ATGATCGATGAAJ\TTATACATCACTTA/*-AGAGACC ACCT^CCCTTTGCTGGACCCGAAC^CCTC.^ATTCTGAAGACATGGATA TCCT’GATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA TCTCC^CCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA 50 60 TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC TATCTGGTTACCCTTGAGC^GCGCAGGAAC^CAGTACGTAGAGGGCGG TGG^.GCTCCCCGGGTGA^.CCGTCTGGTCCAATCTCTACTATC^CCCGT CTCCTCCGTCT^AGA^TCTCAT.WvTCTCCA^CATGGCCACC^.CATC TCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTG GATCACTCGCCAGA^.CTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCG ACTCCTC.^CCCTGGGCGGTGGGTCAGGAGGTGGATCCGGAGGTACCCAG GACTGCTCCTTCC^.CACAGCCCCATCTCCTCCGACTTCGCTGTC^^-AT CCGTGAGCTGTCTGACTACCTGCTTC^GATTACCCAGTCACCGTGGCCT CCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTG GCACAGCGCTGGATGGAGCGGCTC^GACTGTCGCTGGGTCC^GATGCA AGGCTTGCTGGAGCGCGTGP^CACGGACATACACTTTGTCACC^^TGTG CCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAG SEQ ID MO: lo'：

'n f 113 - 9 3 9 9 1 i n k 15 .seq

65 GCTA^CTGCTCTAT^VrGATCGATG^^TTATACATCACTT.^-^GAGACC ACCTAACCCTTTGCTGGACCCGAACAACCTCAATl'CTGAAGACATGGATA TCCTGATGGAACGAAACCT.TCGPvACTCCAAACCTGCTCGCATTCGTAAGG GCTGTC.^GCACTTAG-V^TGCATCAGGTATTGAGGC.\.^TTCTTCGT.AA TCTCC.VvCCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCA-A 70 TCATCATCAAGGCAGGTGACTGGCAAGP^.TTCCGGGAAAAACTGACGTTC TATCTGGTTACCCrrTGAGC；-^GCGCAGGA.^C^ACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTG^CCGTCTGGTCC.\ATCTCTACTATC^CCCGT CTCCTCCGTCTAA^.GAA 丁 CTCATAAAITCTCCAAACATGGCCACCAACATC TCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGA.AGCCCTG 75 GATCACTCGCCAG^CTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCG

O:\92\92747.DOC -150- 200413407 ACTCCTC.\ACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCC GGAGGTGGCACCCAGGACTGCTCCTTCCAACAC^GCCCCATCTCCTCCGA CTTCGCTGTC.^AAATCCGTGAGCTGTCTGACTACCTGCTTC.^GATTACC _ CAGTCACCGTGGCCTCC^CCTGCAGGACGAGGAGCTCTGCGGGGGCCTC 5 TGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGC TGGGTCC^GATGCAAGGCTTGCTGGAGCGCGTG^CACGGAGATACACT TTGTCACCA.\ATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTC CAG SEQ ID NO：170 !0 hflt3-2329iiak6.seq GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC ACCTPl^CCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA 15 TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA TCATCATCAAGGCAGGTGACTGGC^AGAATTCCGGGPvAAAACTGACGTTC TATCTGGTTACCCTTGAGCAAGCGCAGGAAC^CAGTACGTAGAGGGCGG 20 TGGAGGCTCCCCGGGTGAACCGTCTGGTCCA.\TCTCTACTATCAACCCGT CTCCTCCGTCT.\AAGAATCTCATAA*^TCTCCAAACATGGCCGATTACCCA GTCACCGTGGCCTCC.^CCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTG GCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC.\AGACTGTCGCTG GGTCCAAGATGC^GGCTTGCTGGAGCGCGTGAACACGGAGATACACTTT 25 GTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCA GACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAG'CAGCTGGTGGCGC TGAAGCCCTGGATCACTCGCCAG.^CTTCTCCCGGTGCCTGGAGCTGCAG TGTCAGCCCGACTCCTC^CCCTGGGCGGTGGATCCGGAGGTACCCAGGA CTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTC.^AAATCC 30 GTGAGCTGTCTGACTACCTGCTTCAA SEQ ID ：·]〇 : 171 hflt3- 232 9 link?.seq 35 GCT.^ACTGCTCTATA*^TGATCGATGA^TTATACATCACTT.\A-\GAGACC ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGA.TA TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG GCTGTCAAGCACTTAGAP--AATGCATCAGGTATTGAGGCAATTCTTCGTA.^ TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCC^JV 40 TCATCATC^.GGCAGGTGACTGGC^GAATTCCGGGAAAAACTGACGTTC TATCTGGTTACCCTTGAGCAAGCGCAGGAAC.\ACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT CTCCTCCGTCT.^\AGAP-*TCTCAT.\AATCTCC>^CATGGCCGATTACCCA GTCACCGTGGCCTCCA^.CCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTG 45 GCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTG GGTCC^\GATGC.\AGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTT GTCACC.-^TGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCA GACCAACATCTCCCGCCTCCTGCAGGA^ACCTCCGAGCAGCTGGTGGCGC TGA^.GCCCTGGATCACTCGCCAGP*^CTTCTCCCGGTGCCTGGAGCTGCAG 50 TGTCAGCCCGACTCCTC.\ACCCTGGGCGGTGGATCCGGAGGTGGCACCCA GGACTGCTCCTTCC.^CACAGCCCCATCTCCTCCGACTTCGCTGTCAPJ^v TCCGTGAGCTGTCTGACTACCTGCTTC^ SEQ ID :、i〇：172 55 hfIc3-23291inki3.seq GCT'^CTGCTCTATP-J\TGATCGATGAA.^TTATACATCACTT^AAGAGACC ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG 60 GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAAT'TCTTCGTAA TCTCCAu\CCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCC.\A TCATCATC^GGCAGGTGACTGGC^GAATTCCGGGPJ^^CTGACGTTG TATCTGGTTACCCTTGAGCAAGCGCAGG.^AC.^ACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGT'GAACCGT'CTGGTCCAATCTCTACTATCAACCCGT 65 CTCCTCCGT'CTAAAGAATCTCATAAATCTCCAAACATGGCCGATTACCCA GTCACCGTGGvTCTCC.aACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTG GCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTG GGTCC^GATGC.-V\GGCTTGCTGGAGCGCGTG^CACGGAGATACACTTT GTCACC.-V^ATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCA 70 GACC,V\CATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGC - TGP^AGCCCTGC-ATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAG TGTCAGCCCGACTCCTC^CCCTGGGCGGTGGATCCGGAGGTGGCTCAGG GGCAGGTAG7GGTACCCAGGACTGCTCCTTCC.\*\CACAGCCCCATCTCCT CCGACTTCGCTGTC^^AATCCGTGAGCTGTCTGACTACCTGCTTC^ SEQ ID NO：173 75 -151 -

O:\92\92747.DOC 200413407 hflt3 -2329 imk2i .seq GCT^CTGCTCTATAATGATCGATG^\ATTATACATCACTT^\AGAGACC 5 ACCTPu^CCCTTTGCTGGACCCG^CAACCTCAATTCTGAAGACATGGATA TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCArrCGTAAGG GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA TCTCC^CCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCC.\A TCATCATCAAGGCAGGTGAC丁GGCAAGAATTCCGGGAAAAACTGACGTTC 10 TATCTGGTTACCCTTGAGC.\AGCGCAGGAAC^CAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCGATTACCCA GTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTG GCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCA.^GACTGTCGCTG 15 GGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTT GTCACCA^ATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCA GACC.\ACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGC TGA^.GCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAG TGTCAGCCCGACTCCTC^J\CCCTGGGCGGTGGGTCAGGAGGTGGGTCAGG 20 AGGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCT CCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAG CTGTCTGACTACCTGCTTC.V\ SEQ ID MG:174 25 hflt:3-343 51mk:6 .seq

35 40 45 GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTA*\GG GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCC-ACATCCAA TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGT'GAACCGTCT'GGTCCAATCTCTACTATCAACCCGT CTCCTCCCTCTAAAGMTCTCATAAATCTCCAAACVTGGCCGCCTCCAAC CTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACA GCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAG.YTGCAAGGCT TGCTGGAGCGCGTG^CACGGAGATACACTTTGTCACC^AATGTGCCTTT CAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC^CATCTCCCGCCT CCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTC GCCAGPu\CTTCTCCCGGTGCCTGGAC-CTGCAGTGTCAGCCCGACTCCTCA ACCCTGGGCGGTGGATCCGGAGGTACTGCTCCTTCCPu^CACAGCCCCATC TCCTCCGACTTCGCTGTCAP>^TCCGTGAGCTGTCTGACTACCTGCTTCA AGATTACCCAGTCACCGTG SEQ ID MO :17 5 hflt3-34351ink7.seq 50

GCT.^CTGCTCTAT^TGATCGATGA.nATTATACATCACTT.-AAGAGACC 55 60

TCCT'GATGGAACGAAACCTTCGAACTCCAJ^ACCTGCTCGCATTCGT'AAGG 广广 rp 广 ryi 广，i rn m ^ > λ 、广/、rpi 广，\ 广广》Τ*ι '「Τ' rr> 广，\ 广、f*-·、产、-s 、r·"· m 广 γτλ ro 广广、<"p、' 1 Ο 、•一一 * 1 Λ ^ λ L· ^ x L L· 广、λ r'' λ ^ ^ ^ ^ ^ ^ > 、 !· L -(二一、π ο * (一 1 -〇(一L 一 ‘、一 l L 1 ‘w 二一九·、丄心 · rp广、λ ,rnf·«、一一 *\ 、广 λ Λ *Ή广一々广，> ' 、 λ ,一r'p'广广，rnrp广、 i tw λ 二、二·'—1 i. ^ ovjoi λ 4.— TATCTGGTTACCCTTGAGC^.GCGCAGG.aAC^CAGTACGTAGAGGGCGG rp 广广 '广广々 ^ 广.一广，，广户一 ryi 广、,一 ηπ 广 rp 广 /**· m (^ 广、、rp 广广 m、广⑺、m r、 Λ Γ% ^ L V-7 a. ·»«. 1 — n-J *Γ^Ό ν.-. λ. L、χ*· Vw ·Γν^"\ · 'w λ. '-w I. ν— 、▲ ，s— T*W— L CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCGCCTCCAAC 、广.一、ά 一 -» /·**» /-，*. r^> rr» ζ·^* γ-»-> /->· /—»/-> >-> rn rn ^ ^ ^ ^ ^ rr^ ^ ^ ^ ^ ^ ^ ，一·*/"*，**·/"*» 广〆^、 -rt 广广、·广 /·*"» 广 /*> r·*-!p 、广「τ' 广 r~n广，《-n 广，f ^ 广、、ό λ m/—· ^ ，广 /"*· rn LjC'^V- i. ^ 1 ^.'-ur\loAL· ^ o i f-w'oL· i 1 λ . TGCTGGAGCGCGTGA^.CACGGAGATACACTTTGTCACC^^TGTGCCTTT CAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC^-ACATCTCCCGCCT

65 CCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTG.^GCCCTGGATCACTC GCCAG^CTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCA ACCCTGGGCGGTGGATCCGGAGGTGGCACTGCTCCTTCC^CACAGCCCC ATCTCCTCCGACTTCGCTGTC.^aA-^TCCGTGAGvCTGTCTGACTACCTGCT TCP^GATTACCCAGTCACCGTG SEQ ID MO: 17 6 hfic3-5435liaki3.seq 70

GCTA.ACTGCTCTATAATGATCGATGA.^ATTATACATCACTT.\.^GAGACC ACCTAACCCTT'TGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA T C C T G Λ TG G .:v.-\C G AP^.C (Γ T T C G .^^AC T C C A>*\AC C T G C T L G C .-λΤ T C G T AAG G GCTGTCAAGCACT'TAGAAAATGCATCAGGTA.TTGAGGCAATTCTTCGTAA / j 1 L L L i 〇 1 L· t * L· l A ^ i *ΛΑ

O:\92\92747.DOC 152- 200413407 TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC TATCTGGTTACCCTTGAGC.\AGCGCAGGAACP^ACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCGCCTCCAAC 5 CTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACA GCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCT TGCTGGAGCGCGTG.^CACGGAGATACACTTTGTCACC^ATGTGCCTTT CAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC.\ACATCTCCCGCCT CCTGC.^GGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTC 10 GCCAGAACTTCTCCCGCTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCA ACCCTGGGCGGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACTGC TCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGA GCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTG SEQ ID NO:177 15 hflt:3-3435i ink21 . seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA 20 TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCAITCGTAAGG GCTGTC^GCACTTAG^AATGCATCAGGTATTGAGGCAATTCTTCGTA.\ TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC TATCTGGTTACCCTTGAGC^GCGCAGGAAC.^ACAGTACGTAGAGGGCGG 25 TGGAGGCTCCCCGGGTGA.\CCGTCTGGTCCAATCTCTACTATCAACCCGT CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCGCCTCCAAC CTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACA GCGCTGGATGGAGCGGCT'CAAGACTGTCGCTGGGTCCAAGATGCAAGGCT TGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACC.\A.\TGTGCCTTT 30 CAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCX^CATCTCCCGCCT CCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGA.\GCCCTGGATCACTC GCCAGA^.CTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCA ACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGG CTCAGGGGGAGGTAGTGGTAGGACTGCTCCTTCCAACACAGCCCCATCTC 35 CTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTC^G ATTACCCAGTCACCGTG SEQ ID NO :178 hflt:3-5263 li n!<6 . seq 40

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA TCCTGATGGAACGAAACCT'TCGAACTCCAAACCTGCT'CGCATTCGTAAGG GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA 45 TCTCC^CCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCC^-A TCATCiVTCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC TATCTGGTTACCCTTGAGC.^AGCGCAGGAACAACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGC^TCCAATCTCTACT'jVTCAACCCGT _ CTCCTCCGTCTAAAGAATCT'CATAAATCTCCAAACATGGCCGTCGCTGGG 50 TCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGAT.'CACTTTGT CACC^nTGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGA CC.^CATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTG .\AGCCCTGGATCACTCGCCAG.\ACTTCTCCCGGTGCCTGGAGCTGCAGTG TCAGCCCGACTCCTC^CCCTGGGCGGTGGATCCGGAGGTACCCAGGACT 55 GCTCCTTCC；^CACAGCCCCATCTCCTCCGACTTCGCTGTC^AATCCGT ·*η m λ-· λ 、r mm λ ^ λ ^ ^ ^ Λ L c ‘一一 ‘ d ·丄 l 〜"VJnVjrrV l i v. 1 ^ ^ wΟV- x ^rV/Λ CCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCAC AGCGCTGGATGGAGCGGCTC^aGACT SEQ ID MO:17 9 60 hflt:3-6263Iink7 .seq 65 70

GCTA.\CTGCTCTAT^TGATCGATGAAATTATACATCACTT^-AAGAGACC ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA TCCTG.YrGGAACGAAACCTTCGAACTCCAAACdTCGCATTCGTAAGG GCTGTC^GCACTTAG^\AATGCATCAGGTATTGAGGC.\ATTCTTCGT^\ TCTCC^CCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA -TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC TATCTGGTTACCCTTGAGC.^GCGCAGG^C^CAGTACGTAGAGGGCGG 75

TGGAGCCTCCCCGGGTG^CCGTCTGGTCC.^TCTCTACTATCAACCCGT CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCGTCGCTGGG TCCAAGATGC^.GGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGT CACC；^-V：GTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGA CCAACATCTCCCGCCTCCTGCAGGAGACCTCCCAGCAGCTGGTGGCGCTG ^GCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTG

O:\92\92747.DOC -153 - 200413407 TCAGCCCGACTCCTCAACCCTGGGCGGTGGATCCGGAGGTGGCACCCAGG ACTGCTCCTTCC^CACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATC CGTGAGCTGTCTGACTACCTGCTTC.^AGATTACCCAGTCACCGTGGCCTC CAACCTGCAGGr\CGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGG CACAGCGCTGGATGGAGCGGCTCAAGACT SEQ ID NO：130 11111:3-6263 link!3 . seq 10 GCTAACT'GCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACC ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA TCCTGATGGAACGAAACCTT'CGAACTCCAAACCTGCTCGCATTCGTAAGG GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCC^

15 TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC TATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGG TCGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCGT'CGCTGGG TCC^GATGCAAGGvCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGT 20 CACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGA CC-\ACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTG ^GCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTG TCAGCCCGACTCCTCAACCCTGGGCGGTGGATCCGGAGGTGGCTCAGGGG GAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCC 25 GACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTA CCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCC TCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC.^GACT SEQ ID MO :1¾1 30 hflt:3-6263 1ink2i .seq

GCT^CTGCTCTATAATGATCGATG^J^ATTATACATCACTT^hGAGACC ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG 35 GCTGTCMGCACTTAGAAAATGCATCAGGTATTGAGGCAA.TTCT'T'CGTAA TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA TCATCATCAAGGCAGG丁GACTGGCAAGAATTCCGGGAAAAACTGACGTTC TATCTGGTTACCCTTGAGCAAGCGCAGGAAC-^ACAGTACGTAGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCA.\TCTCTACTATCAACCCGT 40 CTCCTCCG丁CTAAAGPuVTCTCATAAATCTCCAAACATGGCCGTCGCTGGG

TCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGT CACCAA.^TGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGA CCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTG AAGCCCTGGATCACTCGCCAGA.^CTTCTCCCGGTGCCTGGAGCTGCAGTG 45 TCAGCCCGACTCCTC^CCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAG GTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCC TTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCT GTCTGACTACCTGCTTCA.\GATTACCC^GTCACCGTGGCCTCC^-CCTGC

50 TGGATGGAGCGGCTC^GACT SEQ ID NO： 132 hf It3-5495imk6 , seq

55 GCT.\ACTGCTCTAT^-\TGATCGATGP'AATTATACATCACTT.\AAGAGACC ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGAC.VTGGATA TCCTGATGG.\ACG,V^.CCTTCG^CTCC；vAACCTGCTCGCATTCGT.\A.GG GCTGTCAAGCAC丁TAGPwXAATGCATCAGGTATTGPvGGCAATTCTTCGTAA TCTCC.^CCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCC^ 60 TCATCATCAAGGCAGGTGACT'GGCAAGAATTCCGGGAAAAACTGACGTTC TATCTGGTTACCCTTGAGCAAGCGCAGG.^C^CAGTACG^AGAGGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCCC.CTTCGTC CAGACC.^CATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGvC 65 GCTGA^GCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGC AGTGTCAGCCCGACTCCTC^CCCTGGGCGGTGGATCCGGAGGTACCCAG GACTGCTCCrTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAAT CCGTGAGCTGTCTGACTACCTGCTTC.^GATTACCCAGTCACCGTGGCCT CC^CCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCCGCTGGTCCTG 70 GCACAGCGCTGGATGGAGCGGCTC.^GACTGTCGCTGGGTCC^GATGCA AGGCTTGCTGGAGCGCGTG^CACGGAGATACACTTTGTCACC^^ATGTG CCTTTCACCCCCCCCCCAGCTGTCTT SEQ ID MO： L 3 3 h£ 1 c3 - 9 4 9 5 I i.nk7 . seq 75

O:\92\92747.DOC -154- 200413407 GCTA^\CTGCTCTATA.\TGATCGATGA.\.ATTATACATCACTT.\AAGAGACC ACCTAACCCTTTGCTGGACCCGAACA.^CCTC.^TTCTGAAGACATGGATA TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG GCTGTC.^AGCACTTAGAAAATGCATCAGGTATTGAGGC^TTCTTCGTAA 5 TCTCCA-^CCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA TC.VrC.VrCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC TATCTGGTTACCCTTGAGC.\AGCGCAGGAACAACAGTACGTAGAGGGCGG TCGAGGCTCCCCGGGTGAACCGT'CTGGTCCAATCTCTACTATCAACCCGT CTCCTCCGTCT^AAGAATCTCAT*\AATCTCC.\AACATGGCCCGCTTCGTC 10 CAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGC GCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGC AGTGTCAGCCCGACTCCTC.\ACCCTGGGCGGTGGATCCGGAGGTGGCACC CAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAA AATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGG 15 CCTCC^CCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTC CTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGAT GCAAGGCTTGCTGGAGCGCGTG^CACGGAGATACACTTTGTCACCAAAT GTGCCTTTCAGCCCCCCCCCAGCTGTCTT SEQ ID MO：134 20 hflc3-9495iink!3.seq

GCTAACTGCTCTAT^TGATCGATGA^ATTATACATCACTT^AAGAGACC ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA 25 TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTA^.GG GCTGTC.\AGCACTTAGAA.\ATGCATCAGGTATTGAGGCA.\TTCTTCGTAA TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCC^ TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC TATCTGGTTACCCTTGAGCAAGCGCAGGAAC.\ACAGTACGTAGAGGGCGG 30 TGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATC^CCCGT CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCCGCTTCGTC CAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGC GCTGA^.GCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGC AGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGATCCGGAGGTGGCTCA 35 GGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCC.\ACACAGCCCCATCTC CTCCGACTTCGCTGTCAA.^ATCCGTGAGCTGTCTGACTACCTGCTTCAAG ATTACCCAGTCACCGTGGCCTCC.\ACCTGCAGGACGAGGAGCTCTGCGGG GGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC.^GAC TGTCGCTGGGTCCA^.GATGCAAGGCTTGCTGGAGCGCGTG^ACACGGAGA 40 TACACTTTGTCACCAA.^TGTGCCTTTCAGCCCCCCCCCAGCTGTCTT SEQ ID NO:135 hf it3- 3 49 5iir.k2i . seq

45 GCTA.\CTGCTCTATAATGATCGATGAAATTATACATCACTT^AAGAGACC ACCT.\ACCCTTTGCTGGACCCGAACAACCTC^TTCTGAAGACATGGATA TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG GCTGTC；^GCACTTAGA.^.ATGCATCAGGTATTGAGGC；aTTCTTCGT.^A TCTCC^CCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCA.^ 50 TCATCATCAAGGCAGGTGACTGGCAAGAAT'TCCGGGA^^AAACT'GACGTTC TATCTGGTTACCCTTGAGC.\AGCGCAGGAAC^CAGTACGTAGAGGGCGG n1^ 广广、r ^ 广 ” ” ” .八 nn z*'· 、 /—»rn /— rr-> λ ' ro ^ m /—· rp、m 广/^ ^ i i w _ i i L. i ovj i U i v- * ^ ^ λ x i

CTCCTCCGTC了A^.GAATCTCATAAATCTCCAAACATGGCCCGCTTCGTC 55 GCTG^GvCCCTGGATCACTCGCCAGA.\CTTCTCCCGGTGCCTGGAGCTGC AGTGTCAGCCCGACTCCTC^CCCTGGGCGGTGGGTCAGGAGGTGGGTCA L?foAULj 1 *〇ΌΓ\ ; L ^ J. I L ^ I onj i L Lj CTCCTTCC^CACAGCCCCATCTCCTCCGACTTCGCTGTC.^^TCCGTG AGCTGTCTGACTACCTGCTTC?-«-AGATTACCCAGTCACCGTGGCCTCC^C 60 CTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACA GCGCTGGATGGAGCGGCTC.\AGACTGTCGCTGGGTCC^GATGC^GGCT TGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACC^A-^TGTGCCTTT CAGCCCCCCCCCAGCTGTCTT 3Ξ0 :D NO:136 65 h f 1 c 3 - 9 3 9 9 L i n>;6 . seq

GCTAACT：：CTCTAT；^TGATCGATG.^^.TTATACATCACTT^\GAGACC ACCT.^CCCTTTGCTGGACCCG^CAACCTC.^TTCTCA.-.GACATGGATA 70 TCCTGATGG；^CG.\AACCTTCGAACTCCA.^\CCTGCTCGCATTCGT^.GG GCTGTC^GCACTTAG^AA_VrGCATCAGGTATTGAGGCrwATTCTTCGT.\A TCTCC.VvCC.VrGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCC.^ TCATCATC；^GGCAGGTGACTGGC.\AGP*-ATTC-：GGGAAA^ACTGACGTTC TATCTGGTTACCCTTGAGC.\AGCGCAGG.\AC.-^CAGTACGTAGAGGGCGG 75 TGGA.^GCTCCCCGGGTG；*.ACCGTCTGGTCC.\ATCTCTACTATCAACCCGT

O:\92\92747.DOC -155- 200413407 CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCACCAACATC TCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTG GATCACTCGCCAG.^ACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCG ACTCCTCA.\CCCTGGGCGGTGGATCCGGAGGTACCCAGGACTGCTCCTTC 5 C.^ACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTC TGACTACCTGCTTC.\AGATTACCCAGTCACCGTGGCCTCC；^CCTGCAGG ACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGG ATGGAGCGGCTCAAGACTGTCGCTGGGTCC.^AGATGC^GGCTTGCTGGA GCGCGTGAACACGGAGATACACTTTGTCACC^ATGTGCCTTTCAGCCCC 10 CCCCCAGCTGTCTTCGCTTCGTCCAG 3EQ ID N〇：187 hflt:3-9 3 991ink7 .seq

15 GCTAACTGCTCTATAATGATCGATGAAiVTTATAC.VTCACTTAAAGAGACC ACCTAACCCTTTGCTGGACCCG^CAACCTCAATTCTGAAGACATGGATA TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAAT'TCTTCGTAA TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA 20 TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAA^jaCTGACGTTC TATCTGGTTACCCTTGAGC^AGCGCAGGAACPvACAGTACGTAGAGGGCGG TGGAAGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGT CTCCTCCGTCTAAAGAATCTCATAAATCTCC.\AACATGGCCACCAACATC TCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTG 25 GATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCG ACTCCTC^CCCTGGGCGGTGGATCCGGAGGTGGCACCCAGGACTGCTCC TTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCA.^^ATCCGTGAGCT GTCTGACTACCTGCTTCAAGATTACCCPvGTCACCGTGGCCTCCAACCTGC AGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGC 30 TGGATGGAGCGGCTCAAGACTGTCGCTGGC-TCCPu^GATGC^AGGCTTGCT GGAGCGCGTGAACACGGAGATACACTTT'GTCACCAAAT'GTGCCTTTCAGC CCCCCCCCAGCTGTCTTCGCTTCGTCCAG SEQ ID MC:138 35 hflt3-9S99iinkI3.seq

GCT^J\CTGCTCTAT.\ATGATCGATGAAATTATACATCACTTA^AGAGACC ACCTAACCCTTTGCT'GGACCCGAACAACCTCAAT'TCTGAAGACATGGATA TCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGG 40 GCTGTC^GCACTTAGAAAATGCATCAGGTATTGAGGCA^.TTCTTCGTAA TCTCCAACCJVTGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA TCJVTCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTC TATCTCGTTACCCTTGAGC^GCGCAGG^C.^CAGTACGTAGAGGGCGG TGGAAGCTCCCTCGGGTGAACCGTCTGGT'CCAATCTCTACTAT'CAACCCGT 45 CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCACC*\ACATC TCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTG GATCACTCGCCAGAA.CTTCTCCCGGTGCCTGGAGCTGCAGTGTCAC-CCCG ACTCCTCA-^CCCTGGGCGGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGT GGTACCCAGGACTGCTCCTTCC^ACACAGCCCCATCTCCTCCGACTTCGC 50 TGTC^^TCCGTGAGCTGTCTGACTACCTGCTTO-AGATTACCCAGTCA CCGTGGCCTCC^.CCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGG CTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCPv^.GACTGTCGCTGGGTC C^GATGCA.^GGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCA -· CC.^^TGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAG SEQ ID MO : 1 8 9 hnlt3-9i991ink2i.seq

GCTAACTGCTCTAT.^ATGATCGATGAAATTATACATCACTTA^GAGACC 60 ACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATA TCCTGATGGAACGAAACCTTCGAACTCCAAACCT'GCTCGCATTCGTAAGG GCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAA TCTCC^CCATGTCTGvCCCTCTGCCACGGCCGCACCCTCTCGACATCCAA TCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAACTGP'CGTTC 65 TATCTGGTTACCCTTGAGC^GCGCAGGA.AC*\ACAGTACGTAGP^GGGCGG TGGAGGCTCCCCGGGTGAACCGTCTGGTCC.\ATCTCTACTATCA.^CCCGT CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACVTGGCCACCAACATC

GATCACTCCCCAG；^ACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCG 70 ACTCCTC,\.-\CCCTGGGCGGTGGGTCAGC7AGGTGGGTCAGGAGGTGGATCC GGAGGTGvGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCC.\ACA CAGCCCCATCTCCTCCGACTTCGCTGTC.\.\AATCCGTGAGCTGTCTGACT ACCTGCTTC.\.-\GATTACCCAGTCACCGTGGCCTCC；u-\CCTGCAGGACGAG GAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGA 75 •JCGGCTC,V\GACTGTCGCTGGGTCCAAGATGC.^AGGCTTGCTGGAGCGCG

O:\92\92747.DOC -156- 200413407 TGAACACGGAGATACACTTTGTCACCA.\ATGTGCCTTTCAGCCCCCCCCC AGCTGTCTTCGCTTCGTCCAG SEQ ID NO:190 5 pMON32390

GGATCCACCATGAGCCGCCTGCCCGTCCTGCTCCTGCTCC.\ACTCCTGGT CCGCCCCGCCATGTCTACAAATCAAGATCTGCCTGTGATCAAGTGTCTTT TAATCAATCATAAGAACAATGiVTTCATCAGTGGGGAAGTCATCATCATAT i〇 CCCATGGTATCAGAATCCCCGGAAGACCTCGGGTGTGCGTTGAGACCCCA GAGCTCAGGGACAGTGTACGPJ\GCTGCCGCTGTGGAAGTGGATGTATCTG CTTCCATCACACTGCAAGTGCTGGTCGATGCCCCAGGGAACATTTCCTGT CTCTGGGTCTTTAAGCACAGCTCCCTGAATTGCCAGCCACATTTTGATTT ACAAAACAGAGGAGTTGTTTCCATGGTCATTTTGAAAATGACAGAAACCC 15 AAGCTGGAGAATACCTACTTTTTATTCAGAGTGAAGCTACC*^ATTACACA ATATTGTTTACAGTGAGTAT.^AGAAATACCCTGCTTTACACATT^GAAG ACCTTACTTTAGAAAAATGGAAAACCAGGACGCCCTGGTCTGCATATCTG AGAGCGTTCCAGAGCCGATCGTGG^TGGGTGCTTTGCGA'TTCACAGGGG GAAAGCTGTAAAGAAGAAAGTCCAGCTGTTGTTAA.\AAGGAGGAAAAAGT 20 GCTTCATGAATTATTTGGGATGGACATAAGGTGCTGTGCCAGAAATGAAC TGGGCAGGGA.^TGCACCAGGCTGTTCACAATAGATCTAAATCAAACTCCT CAGACCACATTGCCACAATTATTTCTTAAAGTAGGGGAACCCTTATGGAT AAGGTGCAAAGCTGTTCATGTGAACCATGGATTCGGGCTCACCTGGGAAT TAGAAAACAAAGCACTCGAGGAGGGCAACTACTTTGAGATGAGTACCTjVT 25 TCAACAAACAGA.^CTATGATACGGATTCTGTTTGCTTTTGTATCATCAGT GGC.^GAAACGACACCGGATACTACACTTGTTCCTCTTCAA-^GCATCCCA GTCAATCAGCTTTGGTTACCATCGTAGAAAAGGGATTTATAAATGCTACC AATTCA.^GTGAAGATTATG^\ATTGACCAATATGAAGAGTTTTGTTTTTC TGTCAGGTTTAAAGCCTACCCACA^ATCAGATGTACGTGGACCTTCTCTC 30 GAAAATCATTTCCTTGTGAGCAAAAGGGTCTTGATAACGGATACAGCATA TCCAAGTTTTGC^ATCAT.^GCACCAGCCAGGAGAATATATATTCCATGC AGAi^AATGATGATGCCC^TTTACCA^J^ATGTTCACGCTGAATATAAGAA GGAP.ACCTCPu^GTGCTCGCAGAAGCATCGGCAAGTCAGGCGTCCTGTTTC TCGGATGGATACCCATTACCATCTTGGACCTGGAAGAAGTGTTCAGACAA 35 GTCTCCCAACTGCACAGAAGAGATCACAGAAGGAGTCTGGAATAGAAAGG CTAACAGAAAAGTGTTTGGACAGTGGGTGTCGAGCAGTACTCTAAACATG AGTGAAGCCATAAAAGGGTTCCTGGTCAAGTGCTGTGCATACA.\TTCCCT TGGCACATCTTGTGAGACGATCCTTTTAAACTCTCCAGGCCCCTTCCCTT TCATCCAAGACAACGAATTCATCATCCTGGGCCTGTTCGGCCTCCTGCTG 40 TTGCTCACCTGCCTCTGTGGAACTGCCTGGCTCTGTTGCAGCCCCAACAG GAAGAATCCCCTCTGGCCAAGTGTCCCAGACCCAGCTCACAGCAGCCTGG GCTCCTGGGTGCCCACAATCATGGAGGAGGATGCCTTCCAGCTGCCCGGC CTTGGCACGCCACCCATCACCAP.GCTCACAGTGCTGGAGGAGGATGAA^J\ GAAGCCGGTGCCCTGGGAGTCCCATAACAGCTCAGAGACCTGTGGCCTCC 45 CCACTCTGGTCCAGACCTATGTGCTCCAGGGGGACCCAAGAGCAGTTTCC ACCCAGCCCCAATCCCAGTCTGGCACCAGCGATCAGGTCCTTTATGGGCA GCTGCTGGGCAGCCCCACAAGCCCAGGGCCAGGGCACTATCTCCGCTGTG ACTCCACTCAGCCCCTCTTGGCGGGCCTCACCCCCAGCCCCAAGTCCTAT GAG^-ACCTCTGGTTCCAGGCCAGCCCCTTGGGGACCCTGGT.\ACCCCAGC 50 CCCAAGCCAGGAGGACGACTGTGTCTTTGGGCCACTGCTCA.\CTTCCCCC TCCTGCAGGGGATCCGGGTCCATGGGATGGAGGCGCTGGGGAGCTTC SSQ ID MO： 191 PMOM30329.seq

GCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTCTTTAGAGCAAGTG AGA^^GATCCAGGGCGATGGCGCAGvCGCTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCAC CCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCC AGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCC.\ACTCCATAGCGGCCTTTTCCTCTACCAGGGG 60 CTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGAC GTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAG^.CTGGGAATGGCCCCTGCCCTGCAG CCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTT GCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCCTAC GTAGAGGGCGGTGGAGGCTCCCCGGGTG^CCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCT 65 CCGTCT 从AGAATCTCAT 从ATCTCCAAACATGGCCACCCAGGACTGCTCCTTCCAACACAGCCCC ATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTC ACCGTGGCCTCCPvACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAG CGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCC^.GATGOAGGCTTGCTGGAGCGCGTGAAC .nCGGAGATnCACTTTGTCACC^TGTGCCTTTCAGCCCCCCCCCAGCTG?CTTCGCTTCGTCCAG 70 ACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGA.^GCCCTGGATCACT CGCCAC^CTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTC.^ACCCTG SEQ ID NO:192 PMOM3 2 1*：" .〇eq 75

O:\92\92747.DOC 157- 200413407 GCCACTCAGGACTGCTCTTTTCAACACAGCCCCATCTCCTCCGACTTCGCTGTCiWXATCCGTGAG CTGTCTGACTACCTGCTTC^GATTACCCAGTCACCGTGGCCTCC^CCTGCAGGACGAGGAGCTC. TGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC^GACTGTCGCTGGG TCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTT 5 CAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC^\CATCTCCCGCCTCCTGCAGGAGACCTCC GAGCAGCTGGTGGCGCTGA.^GCCCTGGATCACTCGCCAG.^ACTTCTCCCGGTGCCTGGAGCTGCAG TGTCAGCCCGACTCCTCAACCCTGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGA.\CCGTCTGGT CCAATCTCTACTATCAACCCGTCT'CCTCCGTCT'AAAGAATCTCATAAATCTCCAAACATGGCTACC CAGGACTGCTCCTTCC.\ACACAGCCCCATCTCCTCCGACTTCCCTGTC.AAA<^TCCGTGAGCTGTCT 10 GACTACCTGCTTC^GATTACCCAGTCACCGTGGCCTCC.\ACCTGCAGGACGAGGAGCTCTGCGGG GGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCPu^GACTGTCGCTGGGTCC^AG ATGC^GGCTTGCTGGAGCGCGTGA.\CACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCC CCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAG CTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAG 15 CCCGACTCCTCAACCCTG 3EQ ID NO:193 PMOM32175.seq

GCCACCCAGGACTGCTCCTTTC^ACACAGCCCCATCTCCTCCGACTTCGCTGTCAAA^.TCCGTGAG 20 CTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAC-GACGAGGAGCTC TGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCA.nGACTGTCGCTGGG TCCA^.GATGCAAGGCTTGCTGGAGCGCGTGA-ACACGGAGATACACTTTGTCACC^-ATGTGCCTTT CAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCC GAGCAGCTGGTGGCGCTGAAGCCATGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAG 25 TGTCAGCCCGACTCCTC^ACCCTGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGT CCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATA^AATCTCCAAACATGGCTACA CCATTAGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTC.^AGTGCTTAGAGCAAGTGAGGAAG ATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCACCCCGAG GAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAG 30 GCCCTGCAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTG CAGGCCCTGGAAGGGATATCCCCCGAGTTC-GGTCCCACCTTGGACACACTGCAGCTGGACGTCGCC GACTTTGCCACCACCATCTGGCAGCAGATGGAAGAACTGGG^-ATGGCCCCTGCCCTGCAGCCCACC CAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGvGTCCTGGTTGCTAGC CATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTTTACGCCACCTTGCGCAGCCC SZQ ID 35 NO：194 DMON32204.seq

GCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTC^GTCTTTAGAGC.^GTG 40 AG^\AGATCCAGGGCGATGGCGCAGCGCTCCAGGAG^GCTGTGTGCCACCTACAAGCTGTGCCAC CCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCC AGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCC.^ACTCCATAGCGGCCTTTTCCTCTACCAGGGG CTCCTGCAGGCCCTGG^GGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGAC GTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGG^GAACTGGGAATGGCCCCTGCCCTGCAG 45 CCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTT GCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCCTAC GTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAJ\TCTCTACTATCAACCCGTCTCCT CCGTCT.^AAG^TCTCATAAATCTCCAAACATGGCCACTCAGGACTGCTCTTTTCA^CACAGCCCC ATCTCCTCCGACTTCGCTGTCAA.\P.TCCGTGAGCTGTCTGACTACCTGCTTCA.^GATTACCCAGTC 50 ACCGTGGCCTCC.^ACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAG CGCTGGATGGAGCGGCTC^GACTGTCGCTGGGTCC^GATGCAJVGGCTTGCTGGAGCGCGTG.^AC ACGGAGATACACTTTGTCACC^^TGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAG ACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGPu^GCCCTGGP^TCACT CGCCAG^\CTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGTACGTAGAG 55 GGCGGTGv3AGGCTCCCCGGGTG.\ACCGTCTGGTCC^.TCTCTACTATC^CCCGTCTCCTCCGTCT AA.\G^.TCTCAT.^ATCTCCA^CATGGCTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCC TCCGACTTCGCTGTCAAAi.TCCGTGAGCTGTCTGACTACCTGCTTC^GATTACCCAGTCACCGTG GCCTCC^CCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGG ATGGAGCGGCTC；vAGACTGTCGCTGGGTCC.\AGATGC^GGCTTGCTGGAGCGCGTGAACACGGAG 60 ATACACTTTGTCACC；-JL*\TGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC^C ATCTCCCGCCTCCTCCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAG .\ACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTp SEQ ID MO：195 pMON32205.seq 65 gct^ctgctctata^tgatcgatga^ttatacatcactt^^gagaccacctgcacctttgctg

GACCCG^u：.W；CTC.\ATGACG^GACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCPJ'vAC

CTGGAGAGCTTCGTAAGGGCTGTCAAGA^CTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGT

AATCTCC^CCATCTCTGCCCTCTGCCACGGCCCCACCCTCTCGACATCC；^TCATCATC.^GGCA 70 GGTGACTCGC^GA^TTCCGGG.^-AA^\CTGACGTTCTATCTGGTTACCCTTGr\GC^GCGCAGGAA CAACAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGT广CAATCTCTACTATCAAC CCGTCTCCTCCGTCTAAAG^TCTCAT.W.TCTCC.^CATGCCCAC^CAGGACTGCTCTTTTC^ CACAGCCCCATCTCCTCCGACTTCGCTGTC^^TCCGTGAGCTGTCTGACTACCTGvCTTC^GAT TACCCAGTCACCGTGGCCTCC.^ACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTC 75 CTGGCACAGCGv-rTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCC.^AGATGCr^GGCTTGCTGGAG

O:\92\92747.DOC -158- 200413407 CGCGTGAACACGGAGATACACTTTGTCACCA^^TGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGC TTCGTCCAGACC^CATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCC TGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTG TACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACT.\TCAACCCGTCT 5 CCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCTACCCAGGACTCCTCCTTCCAACACAGC CCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCA GTCACCGTGGCCTCCA.ACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCA CAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCC^GATGC^GGCTTGCTGGAGCGCGTG AA.CACGGAGATACACTTTGTCACC.\A.\TGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTC I〇 CAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTG^AGCCCTGGATC ACTCGCCAG^CTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTC^.CCCTG S£Q ID MO:196 PMCN32203.seq 15

GCCACTCAGGACTGCTCTTTTCAACACAGCCCCATCTCCTCCGACTTCGCTGTC.\AAATCCGTGAG CTGTCTGACTACCTGCTTC^GATTACCCAGTCACCGTGGCCTCC.^ACCTGCAGGACGAGGAGCTC TGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC.^GACTGTCGCTGGG TCC.\AGATGCAAGGCTTGCTGGAGCGCGTG.\ACACGGAGATACACTTTGTCACC.\AATGTGCCTTT 20 CAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC^CATCTCCCGCCTCCTGCAGGAGACCTCC GAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAG TGTCAGCCCGACTCCTCAACCCTGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGT CCAATCTCTACTATCAACCCGTCTCCTCCGTCTAA^.GAATCTCAT^\ATCTCC^nCATGGCTACA ^ CCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTC^-AGTCTTTAGAGCAAGTGAGAAAG 25 ATCCAGGGCGATGGCGCAGCGCTCCAGGAG^GCTGTGTGCCACCTACAAGCTGTGCCACCCCGAG GAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAG GCCCTGCAGCTGGCAGGCTGCTTGAGCC^CTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTG CAGGCCCTGGA.^GGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCC ^ GACTTTGCCACCACCATCTGGCAGCAGATGGAAG^CTGGG^TGGCCCCTGCCCTGCAGCCCACC

30 CAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGC CATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCCTACGTAGAG GGCGGTGGAGGCTCCCCGGGTG^J\CCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCT AAAGAATCTCATAAATCTCCAAACATGGCTACCCAGGACTGCTCCTTCCAACACAGCCCCA.TCTCC TCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTG 35 GCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGG ATGGAGCGGCTCAAGACTGTCGCTGGGT'CCAAGATGCAAGC-CTTGCTGGAGCGCG丁GAACACGGAG ATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC^C ATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAG AACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTG SEQ ID MO:197 40 pMOM3 5 7〇7.seq/pMCM3 219 I .seq

GGCCACTCAGGACTGCTCTTTTCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGA GCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCT 45 CTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGC.TCA.^GACTGTCGCTGG GTCC^GATGCAAGGCTTGCTGGAGCGCGTG^CACGGAGATACACTTTGTCACC^TGTGCCTT TCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTC CGAGCAGCTGGTGGCGCTG.^AGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCA GTGTCAGCCCGACTCCTCAACCCTGTA(5：GTAGAGGGCGGTGGAGGCTCCCCGGGTGGTGGTTCTGvO 30 CGGCGGCTCC^CATGvGCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTC.^ GTCTTTAGAGCAAGTGAGAAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGA.^GCTGTGTGCCAC CTAC^GCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGAC.\CTCTCTGGGCATCCCCTGGGCTCC CCTGAGCTCCTGCCCCPvGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCC^CTCCATAGCGGCCT TTTCCTCTACCAGGGGCTCCTGCAGGCCCTGG^GGGATATCCCCCGAGTTGGGTCCCACCTTGGA 55 CACACTGCAGCTGGACGTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGG^G.-J\CTGGGAAT GvGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGC AGGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCA CCTTGCGCAGCCG SEQ ID MO:198 60 〇lMOM3 2 3 97 . seq

GCTAACTGCTCTATAATGATCGATGA^.ATTATACATCACTT.\AAGAGACGACCTP^CCCTTTGCTG

GACCCG.^ACr\ACCTCAATTCTG^GACATGGATATCCTGATGGAACGAAACCTTCGAACTCC,\AAC 65 ctgctcgcattcgtaagggctgtcaagcacttagaaaatgcatcaggtattgaggcaattcttcg丁

AATCTCC.\ACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCC^TCATCATC^GGCA GGTGACTGGC^G.\ATTCCGGGAA.\^CTGACGTTCTATCTGGTTACCCTTGAGC^GCGCAGG^\

CAACAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTG^CCGTCTGGTCC.^TCTCTACTATC^C

ccgtctcctccgtct.^ga^tctcata^tctcc.^catggccgattacccagTvACCGTGGCC

70 TCC^CCTCCAGGACGAGGAGCTCTGCGGCGGCCTCTCGCGGCTGGTCCTGGCACAGCGCTGGATG GAGCGGCTC.\AGACTGTCGCTGGGTCC^GATGCAAGGCTTGCTGGAGCGCGTG.\ACACGGAGATA CACTTTGTCACCAP^TGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC^CATC TCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTG.^GCCCTGGATCACTCGCCAGAAC TTCTCCC5GTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTC.\ACCCTGGGCGGTGGGTCAGGAGGT

O:\92\92747.DOC 159- 200413407 GGATCCGGAGGTACCCAGGACTGCTCCTTCCA.^CACAGCCCCATCTCCTCCGACTTCGCTGTC.;^\A ATCCGTGAGCTGTCTGACTACCTGCTTC.^A SEQ ID MO ： 199 PMOM32398.seq 5 GCT*\ACTGCTCTAT^TGATCGATG^^TTATACATCACTT>AAGAGACCACCTA.ACCCTTTGCTG GACCCGAACAACCTC.UTTCTGMGACATGC'VTATCCTGATGGAACGAAACC 了 TCGMCTCCAAAC CTGCTCGCATTCGT^.AGGGCTGTC^GCACTTAGAAAATGCATCAGGTATTGAGGC^\TTCTTCGT AATCT'CCAACCATGTCTGCCCTCT'GCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCA 10 GGTGACTGGC^GAATTCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCPuiGCGCAGGAA CAACAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAAC CCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCGATTACCCAGTCACCGTGGCC TCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATG GAGCGGCTCAAGACTGTCGCTGGGTCC^<\GATGCAAGGCTTGCTGGAGCGCGTGPu\CACGGAGATA 15 CACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCT'TCGTCCAGACCAACATC TCCCGCCTCCTGCAGGAGACC^CCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAG^C TTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTC\ACCCTGGGCGGTGGGTCAGGAGGT GGGTCAGGAGGTGGATCCGGAGGTGGCACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCC GACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTC.\A SEQ ID NO:200 20 DMCN32399.seq GCTAACTGCTCTATAATGATCGATG^^ATTATACATCACTTAAAGAGACCACCTAACCCTTTGCTG GACCCGAAC^CCTCAATTCTGAAGACATGGATATCCTGATGGAACGAAACCTTCGA.\CTCCAAAC 25 CTGCTCGCATTCGTAAGGGCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCA.^TTCTTCGT AJ\TCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCA^.GGCA GGTGACTGGC^GAATTCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAA CAACAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATC.^C ^ CCGTCTCCTCCGTCTAAAG^JVTCTCATAAATCTCCAAACATGGCCGCCTCC^CCTGCAGGACGAG 30 GAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTC GCTGGGTCC.^AGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGT GCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCA^.CATCTCCCGCCTCCTGCAGGAG ACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAG ” CTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGATCCGGAGGTACCCAG 35 GACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTC^AAATCCGTGAGCTGTCTGAC TACCTGCTTCAAGATTACCCAGTCACCGTG SEQ ID MO:201 PMON35700.seq 40 GCTi^CTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTAACCCTTTGCTG GACCCGAACAACCTCAATTCTGAAGACATGGATATCCTGATGGAACGAAACCTTCGAACTCCAAAC CTGCTCGCATTCGTAAGGGCTGTC^GCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGT AATC.TCC^.CCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCA 45 GGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAA CAACAGTACGTAGAAGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCA^.C CCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCGCCTCCAACCTGCAGGACGAG GAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC^.GACTGTC . GCTGGGTCC^GATGC.^GGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGT 50 GCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCA^.CATCTCCCGCCTCCTGCAGGAG ACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAG CTGCAGTGTCAGCCCGACTCCTC^CCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCC GGAGGTGGCACCCAGGACTGCTCCTTCC.^ACACAGCCCCATCTCCTCCGACTTCGCTGTC^-^ATC CGTGAGCTGTCTGACTACCTOCTTCAAGATTACCCAGTCACCGTG SEQ MO:202 55 pMOM3S7〇I.seq GCT^ACTGCTCTATAATGATCGATG^A^.TTATACATCACTT^-AAGAGACCACCT.^ACCCTTTGCTG GACCCGA.;\C^CCTCAATTCTGr\AGACATGGATATCCTGATGGAACGAA^.CCTTCG^.CTCCP*^AC 60 CTGCTCGCATTCGT^GGGCTGTC.^AGCACTTAGAAAATGCATCAGGTATTGAGGC.^TTCTTCGT AATCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCA GGTGACTGGC^.G^TTCCGGGAA.^A^.CTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAA CAACAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCC^TCTCTACTATCAAC . CCGTCTCCTCCGTCTAAAGAATCTCVTAAATCTCCAAACATGGCCGTCGCTGGGT'CCAAGATGCAA 65 GGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCC AGCTGTCTTCGCTTCGTCCAGACCA.\CATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTG GCGCTG.\AGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGAC TCCTC^\CCCTGvGGCGGTGGGTCAGGAGGTGGATCCGGAGGTACCCAGGACTCCTCCTTCC*V»CAC AGCCCCATCTCCTCCGACTTCGCTGTCA.^AATCCGTGAGCTGTCTGACTACCTGCTTC.^AGATTAC 70 CCAGTCACCGTGGCCTCC^CCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTCGCGGCTCGTCCTG GCACAGCGCTGGATGGAGCGGCTCAAGACT SEQ ID MO：203 PMCM3570：.3eq 160-

O:\92\92747.DOC 200413407

GCTAACTGC丁CTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTAACCCTTTGCT'G GACCCGAAC^CCTCAATTCTGAAGACATGGATATCCTGATGGAACGAAACCTTCGAxXCTCC^^AAC CTGCTGGCATTCGTA.AGGGCTGTC.\AGCACTTAG*\AAATGCATCAGGTATTGAGGCAATTCTTCGT AATCTCC.\ACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCC^TCATCATCAAGGCA 5 ggtgactggcaagaattccggg4\aaa.^ctgacgttctatctggttacccttgagcaagcgcaggaa C.\ACAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGA.^CCGTCTGGTCC.\ATCTCTACTATCAAC CCGTCTCCTCCGTCTAAAGAATCTCAT^*\ATCTCC.\AACATGGCCGTCGCTGGGTCCAAGATGCAA GGCTTGCTGGAGCGCGTGPu^CACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCC AGCTGTCTTCGCTTCGTCCAGACC.^ACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTG 10 GCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGAC TCCTCA.\CCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCACCCAGGAC TGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTC^^TCCGTGAGCTGTCTGACTAC CTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTC TGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACT SEQ ID MO:204 15 pMON35703.seq GCTA.\CTGCTCTAT.\ATGATCGATGAAATTATACATCACTTAAAGAGACCACCTAACCCTTTGCTG GACCCGAACAACCTCAATTCTGAAGACATGGATATCCTGATGGAACGAAACCTTCGAACTCCAAAC 20 CTGCTCGCATTCGTAAGGGCTGTCAAGCACTTAGAAA.^TGCATCAGGTATTGAGGCAATTCTTCGT AATCTCC.\ACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCA GGTGACTGGCAAGAATTCCGGGAAA.^CTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAA CAACAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAAC CCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCCGCTTCGTCCAGACCAACATC 25 TCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAG^C TTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGT GGATCCGGAGGTACCCAGGACTGCTCCTTCC*\ACACAGCCCCATCTCCTCCGACTTCGCTGTCAAA ATCCGTGAGCTGTCTGACTACCTGCTTC^.GATTACCCAGTCACCGTGGCCTCCAACCTGCAGGAC GAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACT 30 GTCGCTGGGTCCAAGATGC^AGGCTTGCTGGAGCGCGTG^CACGGAGATACACTTTGTCACC.\AA TGTGCCTTTCAGCCCCCCCCCAGCTGTCTT SEQ ID NO : 205 pMON3 57 0 4. sea

35 GCTAACTGCTCTAT^J\TGATCGATGAAATTATACATCACTTAAAGAGACCACCT,\ACCCTTTGCTG GACCCGAACAACCTCAATTCTGAAGACATGGATATCCTGATGGAACGAAACCT'TCGAACTCCAAAC ctgctcgcattcgtaagggctgtcaagcacttaga^^atgcatcaggtattgaggcaattcttcgt AATCTCC^CCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCA GGTGACTGGCAAGAATTCCGGGAPu^AACTGACGTTCTATCTGGTTACCCTTGAGC^GCGCAGGAA 40 C.^ACAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCC.^ATCTCTACTATC^C CCGTCTCCTCCGTCT^J\AGAATCTCATAAATCTCC*2J^ACATGGCCCGCTTCGTCCAGACC^CATC TCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGC-CGCTGAAGCCCTGGATCACTCGCCAGAAC TTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTC*\ACCCTGGGCGGTGGGTCAGGAGGT GGGTCAGGAGGTGGATCCGGAGGTGGCACCCAGGACTGCTCCTTCC.^ACACAGCCCCATCTCCTCC 45 GACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTC^.GATTACCCAGTCACCGTGGCC TCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATG GAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGC^GGCTTGCTGGAGCGCGTGAACACGGAGATA CACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTT SEQ ID MG :206 50 CMON35705.seq GCT*\ACTGCTCTAT.\ATGATCGATGA^TTATACATCACTTAAAGAGACCACCTAACCCTTTGCTG GACCCGAAC^CCTC^TTCTGAAGACATGGATATCCTGATGG^CGAA^*CCTTCG^CTCC.\AAC CTGCT'CGCATTCGTAAGGGCTGT'CAAGCACT'TAGAAAATGC.VTCAGGTATTGAGGCAATTCTTCGT 55 .-J\TCTCC^CGATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCC；^TCATCATCA.;\GGCP^ GC3TGACTGGCAAGAATTCCGGGi\AA^ACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGG^ CAACAGTACGTAGAGGGCGGTGGAAGCTCCCCGGGTGAACCGTCTGGTCC.^.TCTCTACTATC^.C CCGTCT.CCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCCACCAACA.TCTCCCGCCTCCTG CAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAG^.CTTCTCCCGGTGC 60 CTGGAGCTGCAGTGTCAGCCCGACTCCTCA^.CCCTGGGCGGTGGGTCAGGAGGTGGATCCGGAGGT ACCCAGGACTGCTCCTTCC^CACAGCCCCATCTCCTCCGACTTCGCTGTC^^AATCCGTGAGCTG TCTGACTACCTGCTTC.^GATTACCCAGTCACCGTGGCCTCCiACCTGC^GGACGAGGAGCTCTGC GGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCC AAGATGC^.GGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCA^TGTGCCTTTCAG 65 CCCCCCCCCAGCTGTCTTCGCTTCGTCCAG SEQ ID MO :207 pMOM.357 06 .seq GCTA.ACT3CTCTATA.ATGATCGATGAAATTATACATCACTT-\AJvGAGACCACCT^CCCTTTGCTG 70 GACCCaGCAACCTCA^TTCTGMGACATGGATATCCTGATGGA乂 CGAAACCTTCGMCTCa^

CTGCTCGCATTCGT^\GGGCTGTC.^AGCACTTAG^AATGCATCAGGTATTGAGGC.\ATTCTTCGT .^ATCTCC^CCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCC.\ATCATCATCAAGGCA GGTGACTGGCA^GAATTCCCv3G.^\A^.CTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAA C^CAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATC.^AC 75 CCGTCTCCTCCGTCT.\AAGAATCTCATA^^TCTCC.\AACATGGCCACC.^ACATCTCCCGCCTCCTG -161 -

O:\92\92747.DOC 200413407 CAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGC CTGGAGCTGCAGTGTCAGCCCGACTCCTC^CCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGT GGATCCGGAGGTGGCACCCAGGACTGCTCCTTCCA^.CACAGCCCCATCTCCTCCGACTTCGCTGTC AAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCC.\ACCTC-CAG GACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCA.^G ACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACC AAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAG SEQ ID NO:208 CMON35733.seq 10 GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTAACCCTTTGCTG GACCCGAACAACCTCAATTCTGAAGACJVTGGATATCCTGATGGAACGAAACCTTCGAACTCCAAAC CTGCTCGCATTCGTAAGGGCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGT AATCTCC^CCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATC^J\GGCA 15 GGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAA CAACAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCC^TCTCTACTATC^C CCGTCTCCTCCGTCTA\GAATCTCATAAATCTCCAAACATGGCTTCTAATCTGCAAGATGAAGAG CTGTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC^GACTGTCGCT GGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCC 20 TTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACC TCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTG CAGTGTCP^GCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGA GGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCC^CACAGCCCCATCTCCTCCGAC TTCGCTGTCAA*\*\TCCGTGAGCTGTCTGACTACCTGCTTC*\AGATTACCCAGTCACCGTGGCC 25 SEQ ID NO :209 pMON3 57 3 4.seq · GCTAACTGCTCTATAATGATCGATGA.^.TTATACATCACTTAAAGAGACCACCTAACCCTTTGCTG 30 GACCCGMCAACCTCAATTCTGAAGACATCGATATCCTCATGGAACGAAACCTTCGAACTCCAAAC CTGCTCGCATTCGTAAGGGCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGT AATCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCA GGTGACTGGCA.\GAATTCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAA CAACAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAAC 35 CCGTCTCCTCCGTCT.\^AGAATCTCATAAATCTCCAAACATGGCCAACCTGCAAGATGAAGAGCTG TGTGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC^GACTGTCGCTGGG TCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACAOTTTGTCACCAAATGTGCCTTT CAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCA^.CATCTCCCGCCTCCTGCAGGAGACCTCC GAGCAGCTGGTGGCGCTGA^.GCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAG 40 TGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGT GGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTC GCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCA.\GATTACCCAGTCACCGTGGCCTCC SEQ ID NO:210 45 OMON35735.seq GCTAACTGCTCTATAATGATCGATGAu\ATTATACATCACTTAAAGAGACCACCT^CCCTTTGCTG GACCCGAACAACCTCAATTCTGAAGACATGGATATCCTGATGGAACGAAACCTTCGAACTCCAAAC CTGCTCGCATTCGT^GGGCTGTC.\AGXCACTTAGPu^^TGCATCAGGTATTGAGGC.^ATTCTTCGT 50 ^TCTCC^CCATGTCTGCCCTCTGCCACCtGCCGCACCCTCTCGACATCC.^TCATCATC.-AGGCA GGTGACTGGCAAGAATTCCGGGAAPl^ACTGACGT'TCTATCTGGTTACCCTTGAGCAAGCGCAGGAA CAACAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCA*\TCTCTACTATC.^C CCGTCTCCTCCGTCTAAAGAATCT'CATAAATCTCCAP^CJVTGGCT'CTGCAGGATGAGGAACTGT'GC GGCGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCC 55 ^GATGC^GGCTTGCTGGAGCGCGTGA.nCACGGAGATACACTTTGTCACC^^ATGTGCTTTTCAG CCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC.^CATCTCCCGCCTCCTGCAGGAGACCTCCGAG CAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGvCAGTGT CAGCCCGPvCTCCTC^XCCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGC TCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCT 60 G7CAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCC.-*AC SEQ ID NO：211 PMOM35735.seq '

65 GCT^.CTGCTCTAT.^ATGATCGATGA.^\TTATACATCACTT.\.\.^GAGACCACCT.\-\CCCTTTGCTG GACCCG.\AC.\ACCTC^TTCTGAAGACATGGATATCCTGATGGAACGAAACCTTCGAACTCCAAAC CTGCTCGCATTCGT^GGGCTGTC.^AGCACTTAGAA^^ATGCATCAGGTATTGAGGCAATTCTTCGT PlATCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCC-^TCATCATC.^\GGCA GGTGACTGGCAAGAATTCCGGGAAAAACTCACGTTC丁.VTCTGG丁TACCCrTGAGCAAGCGCAGGAA 70 C.\ACAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTG^ACCGTCTGGTCC^TCTCTACTATC.\AC CCGTCTrCCTCCGTCTAAAGAATCTCATAAATCTCC.^AACATGGCTCAAGATGAAG.AGCTGTGTCGT GGTCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC.\AGACTGTCGCTGGGTCC^G ATGCAAGGCTTGCTGGAGCCCGTGAACACGGAGATACACTTTGTCACC.^AATGTGCCTTTCAGCCC CCCCCCAGCTGTCTTCGCTTCGTCCAGACC.\ACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAG 75 CTGvGTGGCGCTGA^.GCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTCGAGCTGCAGTGTCAG 162-

O:\92\92747.DOC 200413407 7 4 V } CCCGACTCCTC.AACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTCA GGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCC*\ACACAGCCCCATCTCCTCCGACTTCGCTGTC AAAATCCGTGAGCTGTCTGACTACCTCCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTG SEQ ID NO:2i2 5 pM〇N3 57 3 3.seq GCT.\ACTGCTCTATA^.TGATCGATGA.^\TTATACATCACTT^J\GAGACCACCTAACCCTTTGCTG GACCCGAACPv.\CCTCAATTCTGAAGACATGGATATCCTGATGGAACGAAACCTTCGAACTCCA.\AC 10 CTGCTCGCATTCGTt\AGGGCTGTCA.\GCACTTAGAAAATGCATCAGGTATTGAGGC.\.\TTCTTCGT AATCTCCAACCVTGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCA GGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAA CAACAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAAC CCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCTGAAGAACTGTGTGGTGGTCTG 15 TGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAA GGCTTGCTGGAGCGCGTG.^CACGGAGATACACTTTGTCACCAAP.TGTGCCTTTCAGCCCCCCCCC AGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTG GCGCTG^GCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGAC TCCTC^CCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTCAGGGGGA 20 GGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATC CGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGAC SEQ ID NO：213 pMON35739.seq 25 GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTAACCCTTTGCTG GACCCGAACAACCTCAATTCTGAAGACATGGATATCCTGATGGAACGAAACCTTCGAACTCCAAAC CTGCTCGCATTCGTA^*GGGCTGTC.\AGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGT .\ATCTCCAACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCC^TCATCATCAAGGCA 30 GGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAA CAACAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAAC CCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCTGAGCTGTGTGGTGGCCTGTGG CGTCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCA.\GGC TTGCTGGAGCGCGTGA-\CACGGAGATACACTTTGTCACC.\AATGTGCCTTTCAGCCCCCCCCCAGC 35 TGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTC-GCG CTGAAGCCCTGGATCACTCGCCAAAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCC TCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTCAGGGGGAGv^T AGTGGTACCCAGGACTGCTCCTTCCA-^CACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGT GAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCA^.CCTGCAGGACGAG 40 SEQ ID NO：214 pMOM3 57 40.seq

GCTMCTGCTCTAT^TGATCGATGAAATTATACATCACTTAAAGAGACCACCTAACCCTTTGCTG 45 gacccgaacaacctcaattctgaagacatggatatcctgatggaacgaaaccttcgaactccaaac

CTGCTCGCATTCGT^GGGCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGC^TTCTTCGT ^J\TCTCC*\ACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCA.\TCATCATCAAGGCA GGTGACTC.GCAAGAATTCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAA _ CA^CAGTACGTAGAGGGCGGTGGAGGCfCCCCGGGTGAACCGTCTGGTCCA-VTCTCTACTATC^C

50 CCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACA+TGGCTCTGTGCGGTGGTCTGTGGCGT CTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC^GACTGTCGCTGGGTCC.^uXGATGC.-AGGCTTG CTGGAGCGCGTG^CACGGAGATACACTTTGTCACC^\ATGTGCCTTTCAGCCCCCCCCCAGCTGT CTTCGCTTCGTCCAGACC^CATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTG _ _ AAGCCCTGGATCACTCGCCAGPu-\CTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCA 55 ACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGT GGTACCCAGGACTGCTCCTTCC.\ACACAGCCCCATCTCCTCCGACTTCGCTGTC.\AAATCCGTGAG CTGTCTGACTACCTGCTTC.^AGATTACCCAGTCACCGTGGCCTCC^CCTGCAGGACGAGGAG SEQ ID NO：：15 60 pMOM3574i.3eq

GCTAACTGCTCTAT^TGATCGATGP^AATTATACATCACTT.^-AGAGACCACCT.^ACCCTTTGCTG GACCCGAACAACCTCAATTCT'GAAGACATGGATATCCTGATGGAACGAAPiCCTTCGAACT'CCAAAC ， CTGCTCGCATTCGT.\AGGGCTGTC.\AGCACTTAGAAAATGCATCAGGTATTGAGGC^TTCTTCGT

65 .AATCTCC*nACCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCC.^.TCATCATCA^.GGCA

GGTGACTGGCAA.GAATTCCCiGGAAAAACTGACG丁TCTATCTGGTTACCCTTGAGCAAGCGCAGGAA CAACAGTACG7AGAGGGCGGTGGAGGCTCCCCGGGTG^CCGTCTGGTCCA^TCTCTACTATC^-\C CCGTCTCCTCCGT'CTAAAGAATCTCATAAATCTCCAAACATGGCTTCTAATCTCiCAAGATGAAGAG

ctgtgcgggggcctctggcggctggtcctggcacagcgctggatcgagcggct'CAAGACTCTTCGCT

70 GGGTCCAAGATGCAAGGCT'TGCTGGAGCOCGTGAACACGGAGATACACTTTGT'CACCAAATGTCICC TTTCACCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC.^CATCTCCCGCCTCCTGCAGGAGACC TCCGAGCAGCTGGTGGCGCTGA.^GCCCTGGATCACTCGCCAG.\ACTTCTCCCGGTGCCTGGAGCTG CAGTGTCAGCCCGACTCCTC.^CCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGA GGTGGCTCAGaGGGAGGTAGTGGTACCCAGGACTGCTCCTTCC.^ACACAGCCCCATCTCCTCCGAC -163 -

O:\92\92747.DOC 200413407 TCCGCTGTCAAAATCCGTGAGCTGTCTGACTr\CCTGCTTCAAGATTACCCAGTCACCGTGGCC SEQ ID MO：216 5 〇MON3 57 4 2.seq GCT^CTGCTCTATPu^TGATCGATGAA^^TTATACATCACTTAAAGAGACCACCTAACCCTTTGCTG GACCCGAACAACCTCAATTCTGAAGAC-VTGGATATCCTGATGGAACGAAACCTTCGAACTCCAAAC CTGCTCGCATTCGTAAGGGCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGT 10 AATCTCC^CCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCA GGTGACT'GGCAAGAATTCCGGGAAAAACTGACGTT'C 丁 ATCTGGTTACCCTTGAGCAAGCGCAGGAA CAACAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAAC CCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCTCAAGATGAAGAACTGTGCGGT GGTCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC.\AGACTGTCGCTGGGTCCAAG 15 ATGCAAGGCTTGCTGGAGCGCGTG^CACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCC CCCCCCAGCTGTCTTCGCTTCGTCCAGACC.^ACATCTCCCGCCTCCTGCGGGAGACCTCCGAGCAG CCGGTGGCGCTGA.\GCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAG CCCGACTCCTC.^CCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTCA GGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCC.aACACAGCCCCATCTCCTCCGACTTCGCTGTC 20 AJiAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCA.\CCTG SEQ ID NO :217 pMON35743.seq 25 GCTAACTGCTCTAT^TGATCGATG.\A.\TTATACATCACTTAAAGAGACCACCTAACCCTTTGCTG GACCCGAACAACCTCAATTCTGAAGACATGGATATCCTGATGGAACGAAACCTTCGAACTCCAAAC CTGCTCGCATTCGTAAGGGCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGT AATCTCC^CCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCA^.GGCA GGTGACTGGCAAGAATTCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCA^.GCGCAGGAA 30 CAACAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAAC CCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCTCTGTGCGGTGGTCTGTGGCGT CTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC^GACTGTCGCTGGGTCCAAGATGC^GGCTTG CTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGT CTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTG 35 ^GCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCGGCCCGACTCCTCA ACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGT GGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAGATCCGTGAG CTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAG SEQ ID MO :213 40 OMCM32179.seq

GCTGATG.^G.^CTGTGTGGTGGTCTGTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC 45 AAGACTGTCGCTGGGTCCiJ\GATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTC ACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCA.^CATCTCCCGCCTC CTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGG TGCCTGGAGCTGCAGTGTCAGCCCGAC^CCTC^CCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGA GGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCC.^ACACAGCCCC 50 atctcctccgacttcgctgtcaaaatccgtgagctgtctgactacctgcttcaagattacccagtc ACCGTGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGPu^CCGTCTGGTCC-\*VTCTCTACTATC.^C CCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAAC.VTGGCTAACTGCTCTATAATGA'TCGAT GAAATTATACATCACTTA-AAGAGACCACCTAACCCTTTGCTGGACCCGAAC^CCTOATTCTGAA GACATGGATA/TCCTGATGGAACGAAACCT'TCGA^.CTCCAAACCTGCTCGCATTCGTAAGGGCTGTC 55 ^GCACTTAGAA^JVTGCATCAGGTATTGAGGCAATTCTTCGTAATCTCC^CCATGTCTGCCCTCT GCCACGGCCGCACCCTCTCGACATCCA.\TCATCATC.^GGCAGGTGACTGGCA*\GA^.TTCCGGGAJ\ AAACTGACGTTCTATCTGGTTACCCTTGAGC.^GCGCAGG^CAACAG SEQ ID NO :219 CMOM3 5 7 07. sea 60 .

GCGGATCAGGAGCTGTGCGGTGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC AAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTC ACC*\A*\TGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACiCA.\CATCTCCCGCCTC CTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAGGCCCTGGATCACTCGCCAGAACTTCTCCCGG 65 TGCCTGGAGCTGCAGTGTCAGCCCGACTCCTC^CCCTGGGCGGTGGGTCAGGAGGTGGATCCGGA GGTACCCAGGACTGCTCCTTCC.^CACAGCCCCATCTCCTCCGACTTCGCTGTCA.^J\TCCGTGAG CTGTCTGACTACCTGCTTC^JaGATTACCCAGTCACCGTGGCCTCC.\ACCTGCAGTACGTAGAGGGC GGTGGAGGCTCCCCGGGTGAACCGTC 丁 GGT'CCAATCTCTACTATCAACCCGTCTCCT'CCGTCT'AAA G^\TCTCAT.^TCTCC^CATGGCT.\ACTGCTCTAT^TGATCGATGA.\.\TTATACATCACTTA 70 .aAGAGACCACCT.\ACCCTTTGCTGGACCCGAACAACCTC\\ATTCTGAAGACATGGATATCCTGATG GAACGAAACCTT'CGAACTCCAAACCTGCTCGCATTCGTAAGGGCTGTCAAGC.ACTTAGAAAAT'GCA TCAGGTATTGAGGC；^TTCTTCGT.\ATCTCC；vACCATGTCTGCCCTCTGCCACGGCCGCACCCTCT CGACATCC^VrCATCATC.^AGGCAGGTGACTGGCAAGA,\TTCCGGGAAAAACTGACGTTCTATCTG GTTACCCTTCAGCAAGCGCAGG.^C^CAG SEQ ID MO : 220 75 -164-

O:\92\92747.DOC 200413407 y4 tvu y j v IOU / pM0N3 5 7 0 8.seq GCCGACGAGGAGCTGTGvCGGTGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC AAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTC 5 ACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTC CTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGG TGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGA GGTGGATCCGGAGGTGG^CCCAGGACTGCTCCTTCC.^ACACAGCCCCATCTCCTCCGACTTCGCT GTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCC^CCTG 10 CAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCG TCTCCTCCGTCTPu^-\GAATCTCATAAATCTCC^-ACATGGCTAACTGCTCTAT.\ATGATCGATGAA ATTATACATCACTTAAAGAGACCACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGAC ATGGATATCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGGGCTGTCAAG CACTTAGAAAATGC‘VTCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCATGTCTGCCCTCTGCC 15 ACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAA CTGACGTTCTATCTGGTTACCCTTGAGC.^AGCGCAGGAACAACAG SEQ ID MO :221 pMON357〇9.seq

20 GCAGACGAGGAGCTGTGCGGTGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC AAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTC ACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTC CTGCAGGAGACCT'CCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACT'CGCCAGAACTTCTCCCGG TGCCTGGAGCTGCAGTGTCAGCCCGACTCCTC^ACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGA 25 GGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCA.^CACAGCCCC ATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTC^GATTACCCAGTC ACCGTGGCCTCC.\.\CCTGCAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCA ATCTCTACTATCAi.CCCGTCTCCTCCGTCTAAAGAATCTCATA^ATCTCCAAACATGGCT.^CTGC TCTATAATGATCGATG^J\ATTATACATCACTTAAAGAGACCACCTAACCCTTTGCTGGACCCG^C 30 AACCTCA.VTTCTGAAGACATGGATATCCTGATGGAACGAAACCTTCGAACTCC^\ACCTGCTCGCA TTCGTAAGGGCTGTC^GCACTTAGAAAATGCATCAGGTATTGAGGCA.^TTCTTCGTA.\TCTCC.\A CCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGG CAAGAATTCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAG SEQ ID NO:222 35 PMOM35710.seq

GCGGACGAGGAGCTGTGCGGTGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC AAGACTGTCGCTGGGTCCAAGATGC^GGCCTGCTGGAGCGCGTGAACACGGAGATACACTTTGTC 40 ACC.\AJ\TGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCCTCGTCCAGACC.\ACATCTCCCGCCTC CTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGA^*GCCCTGGATCACTCGCCAGAACTTCTCCCGG TGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGA GGTGGATCCGGAGGTGC-AACCCAGGACTGCTCCTTCCA.^CACAGCCCCATCTCCTCCGACTTCGCT GTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTG 45 CAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCG TCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCTAACTGCTCTAT.\>.TGATCGATGAA ATTATACATCACTT.^AAGAGACCACCTAACCCTTTGCTGGACCCGAACA^rCTCAATTCTGAAGAC ATGGATATCCTGATGGAACGAAACCTTCGAACTCC.iAACCTGCTCGCATTCGTAAGGGCTGTC^VG CACTTAGAA.AATGCATCAGGTATTGAGbCAATTCTTCGTA.\TCTCC.\ACCATGTCTGCCCTCTGCC 50 ACGGCCGCACCCTCTCGPvCATCCAATCATCATC.^AGGCAGGTGACTGGCAAGAATTCCGGG^AAAA CTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAAC^*ACAG SEQ ID MO :223 pMOM357 i1.seq 55 GCGGATGAGGAGCTGTGTGGTGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGGGCGGCTC A-A.GACTGTCGCTGGGTCC^\GATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTC ACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCT'C CTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTG.^GCCCTGGr\TCACTCGCCAGAACTTCTCCCGG TGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGA 60 GGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCC ATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTC ACCGTGGCCTCC^CCTGCAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTG^CCGTCTGGTCCA ATCTCTACTATC^CCCGTCTCCTCCGTCT.^AAGAATCTCATAAATCTCCA.\ACATGGCTA.ACTGC TCTAT^TGATCGATGAAATTATACATCACTTAAAGAGACCACCTAACCCTTTGCTGGACCCG^C 65 AACCT'CAATTCTGAAGACAl'GGATATCCTGATGGAACGA^AACCTTCGAACTCCAAACCTGCTCGCA TTCGTAAGGGCTGTC.V'GCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAA CCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATC^-AGGCAGGTGACTGG CAAGAATTCCGGGAAXAACTa'CGTTCTATCTGGTTACCCrTGAGCAAGCGCAGGAACAACAG SEQ ID MO :2：4 70 PMON3571?.seq

GGCCCATTACCCAGTCACCGTGGCCTCC^CCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCG GCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC.\AGACTGTCGCTGGGTCC^GATGCrvAGGCTT 75 GCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTG

O:\92\92747.DOC -165 - TCTTCGCTTCGTCCAGACC^CATCTCCCCCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCT GAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTC AACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCACCCAGGACTGCTC CTTCCAACACAGCCCC'TCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCT TCAATACGTAGAGGGCGGTGGAGGCTCCCCGGGTGA.\CCGTCTGGTCCAATCTCTACTATCAACCC GTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCTAACTGCTCTATAATGATCGATGA AATTATACATCACTTAAAGAGACCACCT.\ACCCTTTGCTGGACCCGAACAACCTC^TTCTGAAGA CjVTGGATiVrCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGGGCTGTCAA GCACTTAGAAAATGCATCAGGT'ATTGAGGCAATTCTTCGT'AATCTCCAACCATGTCTGCCCTCTGC CACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAA ACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACA.\CAG SEQ ID NO:225 PMCM35720.seq GCCGCCTCC.\ACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGC TGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACG GAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC AACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGC CAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTC.^ACCCTGGGCGGTGGGTCA GGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCACCCAGGACTGCTCCTTCCAACACAGCCCCATC TCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTC.^AGATTACCCAGTCACC GTGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCC^TCTCTACTATC*\ACCCG TCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCTAACTGCTCTATAATGATCGATGAA ATTATACATCACTTAAAGAGACCACCTiU.CCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGAC ATGGATATCCTGATGGAACGAAACCTTCGAACTCC.^AACCTGCTCGCATTCGTAAGGGCTGTCAAG CACTTAGAA.\ATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCATGTCTGCCCTCTGCC ACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAi.GAATTCCGGGAAAAA CTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAG S£Q ID MO :226 ?MON35721.seq GCCGTCGCTGGGTCCAP*.GATGCAA.GGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACC AAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC.^CATCTCCCGCCTCCTG CAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGC CTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGT GGATCCGGAGGTGGCACCCAGGACTGCTCCTTCC.^CACAGCCCCATCTCCTCCGACTTCGCTGTC AA^^TCCGTGAGCTGTCTGACTACCTGCTTCAGGATTACCCAGTCACCGTGGCCTCC*\ACCTGCAG GACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAG ACTTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCG TCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCTAACTGCTCTATAATGATCGATGA.^ ATTATACATCACTT^AAGAGACCACCT^J\CCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGAC ATGGATATCCTGATGG^CGAAACCTTCGAACTCCAAACCTGCTCGCATTCGT^J\GGGCTGTCAAG CACTTAG^AA.\TGCATCAGGTATTGAGGC.^TTCTTCGTAATCTCCAACCATGTCTGCCCTCTGCC ACGGCCGCACCCTCTCGACATCCAATCATCATC.\AGGCAGGTGACTGGC^J\GAATTCCGGGAAAAA CTGACGTTCTATCTGGTTACCCTTGAGC^GCGCAGGA^.CAACAG SEQ ID NO: 2 27 pMON35722.seq GCCTCC.\.^GATGC^GGCTTGCTGGAG't：GCGTG.\ACACGGAGATACACTTTGTCACC^\ATGTGCC TTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC^-ACATCTCCCGCCTCCTGCAGGAGACC TCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAG^CTTCTCCCGGTGCCTGGAGCTG CAGTGTCAGCCCGACTCCTC.^CCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGA GGTGGCACCCAGGACTGCTCCTTCC^CACAGCCCCATCTCCTCCGACTTCGCTGTC^^TCCGT GAGCTGTCTGACTACCTGCTTC^GATTACCCAGTCACCGTGGCCTCC-^CCTGCAGGACGAGGAG CTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC^J\GP^CTGTCGCT GGCTACGTAGAGGGCGGTGGAGGCTCCCCGGGTG^CCGTCTGGTCC^TCTCTACTATC^CCCG TCTCCTCCGITCTAAAGAATCTCATAAATCTCCAAACATGGCTAACTGCTCTATAATGATCGATGAA ATTATACJVTCACTTAAAGAGACCACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGAC ATGGATATCCTGATGGAACG^\ACCTTCGAACTCC；^J\CCTGCTCGCATTCGTA.^GGGCTGTCAAG CACTTAGAAA^.TGCATCAGGTATTGAGGCP»ATTCTTCGTAATCTCC.\ACCATGTCTGCCCTCTGCC ACGGCCGCACCCTCTCGACAT'CCAATCATC.VrCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAA CTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAG SEQ ID MO :228 v pMON35723.seq

GCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC^CATCTCCCGCCTCCTGCAGGAGACCTCCGAG

CAGCTGGTGGCGCTGA-^GCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGT

CAGCCCGACTCCTC.^ACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGC

?ACCCAGGACTGCTCCTTCC.^nCACAGCCCCATCTCCTCCGACTTCGCTGTCAAA.^TCCGTGAGCTG

TCTGACTACCTGCTTC^GATTACCCAGTCACCGTGCCCTCCA*\CCTGCAGGACGAGGAGCTCTGC

GGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC.^AGACTGTCGCTGGGTCC

AAGATGC^GGCTTGCTGGAGCGCGTG^CACGGAGATACACTTTGTCACC^^ATGTGCCTTTCAG

CCGTACGTAGAGGGCCGTGGAGGCTCCCCGGGTG^CCGTCTGGTCC^TCTCTACTATC^CCCG tctcctccgtctaaagaatctcataaatctccaaacatggctaactgctctataatgatcgatgaa

ATTATACATCACTT.-V^GAGACCACCT^CCCTTTGCTGGACCCCAAC.^CCTC.^ATTCTGAAGAC 200413407 ATGGATATCCTGATGGAACG*\AACCTTCGAACTCC.\AACCTGCTCGCATTCGTAAGGGCTGTCAAG CACTTAGAAAATGCATCAGGTATTGAGGC^TTCTTCGTAATCTCCAACCATGTCTGCCCTCTGCC ACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAA CTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAG SEQ ID MO :229 pMOM3 5 7 2 5.seq GCCACC.kACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGPLAGCCCTGGATC . ACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTC^CCCTGGGCGGT 10 GGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCACCCAGGACTGCTCCTTCCAACACAGC CCCATCTCCTCCGACTTYGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTC^GATTACCCA GTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCA CAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGC^GGCTTGCTGGAGCGCGTG AACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTC 15 CAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCG TCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCTAACTGCTCTATAATGATCGATGAA ATTATACATCACTTAAAGAGACCACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGAC ATGGATATCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGGGCTGTCAAG CACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCATGTCTGCCCTCTGCC 20 ACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTC-GCAAGAATTCCGGGAAAAA CTGACGTTCTATCTGGTTACCCTTGAGC^AGCGCAGGAACAACAG SEQ ID MO：230 pMCN3 572 6.seq

25 GCCCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTG AAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTC^ ACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCACCCAGGACTGCTCC TTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTT CAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGG 30 CTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAA.GGCTTG CTGGAACGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGT TTTTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCG TCTCCTCCGTCTAAAGAATCTCAT^J^TCTCCAAACATGGCTAACTGCTCTATAATGATCGATGAA ATTATACATCACTTAAAGAGACCACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGAC 35 ATGGATATCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGGGCTGTCAAG CACTTAGAAA^.TGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCATGTCTGCCCTCTGCC ACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAA CTGACGTTCTATCTGGTTACCCTTGAGC^-AGCGCAGGAACAACAG 3EQ ：D NO： 231 40 pMCM35744.seq

GCTTCAAATCTGCAGGATGAAGAGCTGTGCGGGGGCCTCTGGCGGCTGGT'CCTGGCACAGCGCTGG ATGGAGCGGCTCAAGACTGTCGCTGGGTCCA^.GATGC^J\GGCTTGCTGGAGCGCGTGAACACGGAG ATACACTTTGTCACCA^J^TGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAAC 45 ATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAG AACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGA GGTGGGTCAGGAGGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTC CAACACAGCCCCA丁CTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAA GATTACCCAGTCACCGTGGCCTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAJkCCGTCTGGTCCA 50 ATCTCT'ACTJVTCAACCCGTCT'CCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCTAACTGC TCTATA^TGATCGATG^^ATTATACATCACTT^iGAGACCACCT^CCCTTTGCTGGACCCG^C AACCTCAATTCTGAAGACATGGA.TATCCTGPvTGGAACGAAACCT'TCGAACTCCAAACCTGCTCGCA TTCGTAAGGGCTGT'CAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAA CCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCC*\ATCATCATCV\GGCAGGTGACTGG 55 CAAGAATTCCGGGA^^CTGACGTTCTATCTGGTTACCCTTGAGCA-^GCGCAGG^.CPu^CAG SEQ ID NO :232 pMON3 57 4 5.seq 60 GCTAATCTGC^GATGAGGAGCTGTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATG GAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTOAACACGGAGATA CACTTTGT'CACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTC+GTCCAGACCAACATC TCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAAC TTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTC.^ACCCTGGGCGGTGGGTCAGGAGGT 65 GGGTCAGGAGGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCC.^A CACAGCCCCATCTCCTCCGACTTCGCTGTC.^AAATCCGTGAGCTGTCTGACTACCTGCTTC^.GAT TACCCAGTCACCGTGGCCTCCTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGA.^CCGTCTGGTCCA ATCT'CTACTATCAACCCGTCl'CCTTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCTAACT'GC TCTAT.WTGATCGATGAAATTATACATCACTT.\A.ACAGACCACCT.\ACCCTTTGCTGGACCCGA,AC 70 *\ACCTC.\ATTCTGP^.GACATGGATATCCTGATGGAACGAA.^CCTTCG*;\ACTCC*^AACCTGCTCGCA TTCGT.\AGGGCTGTC.\AGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTA^.TCTCC.^A CCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCC.^ATCATCATCAAGGCAGGTGACTGG CA.AGAATTCC3GGAAAAACTGACGTTCTATCTGGTTACCCTTGAGC.\AGCGCAGGAACAACAG SEQ ID NO：233 75

O:\92\92747.DOC -167- 200413407 OM0M35746.seq GCGCTGCAGGATC.^AGAGCTGTGTGGCGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTTGATGGAG CGGCTC^GACTCTCGCTGGGTCC.^GATGCAAGGCTTGCTGGAGCGCGTG.\ACACGGAGATACAC 5 TTTGTCACCA.\ATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCC CGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTC TCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGG TCAGGAGGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACAC AGCCCCATCTCCTCCGACTTCGCTGTC^^ATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTAC 10 CCAGTCACCGTGGCCTCC.^CTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGA-^CCGTCTGGTCCA ATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAAC-VTGGCTAACTGC TCTATAATGATCGATGAAATTATACATCACTT^^GAGACCACCTAACCCTTTGCTGGACCCGAAC AACCTCAATTCTGAAGACATGGATATCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCA TTCGTAAGGGCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATT'CTTCGTAATCTCCAA 15 CCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCC.^TCATCATC.\AGGCAGGTGACTGG CAAG^TTCCGGGAAA.\ACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGG^CA^.CAG SEQ ID MO :234 % pMOM35747.seq

GCGC.\AGATGAGGAACTGTGTGGTGGTCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGG CTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTT GTCACCPu\ATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC.\ACATCTCCCGC CTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCC 25 CGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCA GGAGGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCC*\ACACAGC CCCATCTCCTCCGACTTCGCTGTCA^AATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCA GTCACCGTGGCCTCCA.\CCTGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGr\ACCGTCTGGTCCA ^ ATCTCTACTATCAACCCGTCTCCCCCGTCTAJ^AGAATCTCAT^AATCTCC^AACATGGCT.^CTGC 30 TCTAT^TGATCGATGAAATTATACATCACTT.\^j\C-AGACCACCTA^.CCCTTTGCTGGACCCGAAC AACCTCP>J\TTCTGA^.GACATGGATATCCTGATGGAACGP-^CCTTCGAACTCC^J\CCTGCTCGCA TTCGTAAGGGCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAA CCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATC.-.AGGCAGGTGACTGG CAAGAATTCCGGGAAAAACTGACGTTCTATCTGGTTA.CCCTTGAGCAAGCGCAGGAACAACAG 35 SEQ ID MO：23 5 PMOM35743.seq GCTGAAGAACTGTGTGGTGGCCTGTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAG 40 ACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACC AAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTG CAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGC CTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGC-GTCAGGAGGT • GGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATC 45 TCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACC GTGGCCTCCAACCTGCAGGACTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCA ATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCTAACTGC TCTATAATGATCGATGA^J\TTATACATCACTTA^J\GAGACCACCT.^CCCTTTGCTGGACCCGA^.C 从 CCTCAATTCTGAAGACATGGATATCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCA 50 TTCGTAAGGGCTGTCAAGCACTTAGAA.^ATGCATCAGGTATTGAGGCAATTCTTCGT.\ATCTCCAA CCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCC^TCATCATC.-.AGGCAGGTGACTGG C.\AGA^.TTCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGA.\CAACAG SEQ ID MO：236 55 DMOM35749.seq

GCTCTGTGCGGTGGCCTGTGGCGTCTGGTCCTGGCACAGCGCTGGATGGAGCGvjCTCAAGACTGTC GCTGGGTCC?^AGATGCAAGGCTTGCTGGAGCGCGTG^CACGGAGATACPvCTTTGTCACC.\AATGT GCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAG 60 ACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAG CTGCAGTGTCAGCCCGACTCCTCA^.CCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCC GGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCC GACTTCGCTGTC^^AAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCC TCC^.CCTGCAGGACGAGGAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTG.\ACCGTCTGGTCCA 65 ATCTCTACTATC^.CCCGTCTCCTCCGTCTAAAGA^.TCTCATAAATCTCC*\AACATGGCTAACTGC TCTATAATGATCGATGAAATTATACATCACTTAA*\GAGACCACCT.\ACCCTTTGCTGGACCCGPaC AACCrrC.\ATTCTGAAGACATGGATATCCTGATGGA.^CG^\ACCTTCGAACTCCAAACCTGCTCGCA TTCGT.^GGGCTGTC.\AGCACTTAGAAAu\TGCATCAGGTATTGAGGCAATTCTTCGT^TCTCC^A CCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCC.^ATCATCATC.^GGCAGGTGACTGG 70 CAACAATTCCCGGAAAAACTCACGTrCTATCTCGTTACCCTZ'CAGC^AGCCCAGGAACAACAC SEQ ID MO；237 PMOM35750.seq -168-

O:\92\92747.DOC 200413407 GCACTGTGTGGTGGTCTGTGGCGTCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCA-AGACTGTC GCTGGGTCCAAGATGC.^AGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGT GCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAG ACCTCCGAGCAGCTGGTGGCGCTG^GCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAG 5 CTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCC GGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCC GACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCC TCC^CCTGCAGGACGAGGAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTG.^CCGTCTGGTCCA ATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCT'CATAAATCTCCAAACATGGCTAACTGC 10 TCTPvTAATGATCGATGAAATTWTACATCACTTAAAGAGACCACCTAACCCTTTGCTGGACCCGAAC AACCTCAATTCTGAAGACATGGATATCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCA TTCGTAAGGGCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAA CCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCA.\TCATCATC^GGCAGGTGACTGG CAAGAATTCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAG 15 SEQ ID NO:238 pMOM35769.seq

GCTCTGTGTGGCGGTCTGTGGCGTCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCA.^GACTGTC 20 GCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTG^CACGGAGATACACTTTGTCACC^^ATGT GCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC^CATCTCCCGCCTCCTGCAGGAG ACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAG CTGCAGTGTCGGCCCGACTCCTCAACCCTGGvGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCC GGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCC^CACAGCCCCATCTCCTCC 25 GACTTCGCTGTCAAGATCCG'TGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCC TCCAACCTGCAGGACGAGGAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCA ATCTCTACTATCA.\CCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCTA-\CTGC TCTAT^TGATCGATGAAATTATACATCACTTAAAGAGACCACCTAACCCTTTGCTGGACCCGAAC AACCTC^TTCTGAAGACATGGATATCCTGATGGAACG^JkACCTTCGAACTCCAAACCTGCTCGCA 30 TTCGTAPvGGGCTGTCAAGCACT'TAGAAAATGCATCAGGTATTGAGGCAATTCTTCGT'AATCTCCAA CCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCC^TCATCATC^GGCAGGTGACTGG CAAGAATTCCGGGAAAAACTGACGTTCTATTCTGGTTTACCCTTGAGCAAGCGCAGGAACAACAG SEQ ID MO：239 35 pMQN3577i.seq

GCCTCC^GATGC.^AGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCC TTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACC TCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTG 40 CAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGA GGTGGCACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAPu-.TCCGT GAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCC^J\CCTGCAGGACGAGGAG CTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCT GGCTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCG 45 TCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCTAACTGCTCTATAATGATCGATGAA ATTATACATCACTTAAAGAGACCACCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGA^.GAC ATGGATATCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCATTCGTAAGGGCTGTCAAG CACTTAG^^TGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCATGTCTGCCCTCTGCC acggccgcaccctctcgacatccaatcAtcatcaaggcaggtgactggcaag.^attccgggp^aa 50 CTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGG^-AC.^ACAG SEQ ID MO: 2 40 pM〇N3 577 4.seq GCTCAAGATGATGAGCTGTGTGGTGGTCTCTGGCGGCTGGTCCTGGCAC?-vGCGCTGGATGGAGCGG 55 CTCAAGACTGTCGCTGGGTCCA^GATGC^GGCTTGCTGGAGCGCGTG.^CACGGAGATACACTTT GTCACC.^\ATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGC CTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTG^AGCCCTGGATCACTCGCCAGPu^CTTCTCC CGGTGCCTGGAGCTGCAGTGTCAGCCCGPvCTCCTC^-ACCCTGGGCGGTGGGTCAGGAGGTGGGTCA GGCGGTGGTTCTGGCGGAGGATCCGGCGGCGG^AGCGGAGGTGGCTCTGGGGGAGGTAGTGGTACC 60 CAGGACTGCTCCTTCC^CACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCT GACTACCTGCTTC.\AGATTACCCAGTCACCGTGGCCTCC^CCTGTACGTAGAGGGCGGTGGAGGC TCCCCGGGTGAACCGTCTGGTCC^\TCTCTACTATCAACCCGTCTCCTCCGTCT.\AAGAATCTCAT .AAATCTCC.2^AACATGGCTA.\CTGCTCTATAATGATCGATGAA^TTATACATCACTTAAAGAGACCA CCTAACCCTTTGCTGGACCCGAACAACCTCAATTCTGAAGACATGGATATCCTGATGGAACGAAAC 65 CTTCGAACTCCAAACCTGCTCGCATTCGTAAGGGCTGTCAAGCACTTAGAAAATGCATCAGGTATT GAGGC.\ATTCTTCGT.^TCTCC.^CCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCA ATCATCATC^GGCAGGTGACTGGCAAGAATTCCGGGAA.^AACTGACGTTCTATCTGGTTACCCTT GAGCAAGCGCAGGAACAACAG 5EQ ID MO:241 70 seq

GCCC.\AGATGAAGA.ACTGTGTGGTGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGG CTC,\AGACTGTCGCTGGGTCCAAGATGCA^GGCTTGCTGGAGCGCGTGAACACGGAGATACACTTT GTCACC.^^ATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGC ) r- ▲CCTGmGGAGACCTCCGPvGCAGCTGGTGGCCCTGAAGCCCTGGATCACTCGCCAGAACTTCT'CC O:\92\92747.DOC -169- 200413407 V八 / 't W y ^ \ I /

CGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTC.^ACCCTCCCGCCACCGTGGAGCCCGCGTCCA CTCGGCGCCACCGCACCGACCACCCAGGACTGCTCCTTCC.\.ACACAGCCCCATCTCCTCCGACTTC GCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAAC CTGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAP-.TCTCTACTATCA^XCCCG 5 TCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCTAACTGCTTCTATAATGATCGATGAA ATTA?ACATCACTTAAAGAGACCACCTAACCCTTTGCTGGACCCGAACAACCTCA.^TTCTGAAGAC

Atggatatcctgatggaacgaaaccttcgaactccaaacctgctcgcattcgtaagggctgtcaag CACTTAG^AAATGCATCAGGTATTGAGGC^TTCTTCGTAATCTCCAACCATGTCTGCCCTCTGCC ACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAA l〇 CTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAG 3EQ ID MO: 242 pMON35776.seq GCCC.\AGATG^.AGAACTGTGTGGTGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGG 15 CTC.^AGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTT GTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC.\ACATCTCCCGC CTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCC CGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTC*\ACCCTGCCGCCACCGTGGAGCCCGCGTCCA CTCGGCGCCACCGCACCGACCGCTGGACAACCGCCTCTGACCCAGGACTGCTCCTTCCAACACAGC 20 CCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCA GTCACCGTGGCCTCCAACCTGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCA ATCTCTACTATC^CCCGTCTCCTCCGTCTAAAG*\ATCTCATAAATCTCC^AACATGGCTA^.CTGC TCTATAATGATCGATGAAATTATACATCACTT^AAGAGACCACCTAACCCTTTGCTGGACCCGAAC AACCTCAATTCTGAAGACATGGiVTATCCTGATGGAACGAAACCTTCGAACTCCAAACCTGCTCGCA 25 TTCGTAAGGGCTGTCAAGCACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAA CCATGTCTGCCCTCTGCCACGGCCGCACCCTCTCGACATCCAATCATCATC.^GGCAGGTGACTGG C^GAATTCCGGG^AAACTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAG SEQ ID NO：243 ' 30 pMOM32159.seq/pMGN40000.seq

GCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCA-^GTCTTTAGAGCA.\GTG AGAAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCAC 35 CCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCC AGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGGG CTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGAC GTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCTGCCCTGCAG CCCACCCAGGGTGvCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTT 40 GCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCCTAC GTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATC^CCCGTCTCCT CCGTCTAAAGAATCTCATAAATCTCC^-AACATGGCTGATGAAGAACTGTGTGGTGGTCTGTGGCGG CTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTG CTGGAGCGCGTG^CACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGT 45 CTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTG AAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCA ACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGT ggtacccaggactgctccttcc^.cacagccccatctcctccgacttcgctgtca^^tccgtgag CTGTCTGACTACCTGCTTC.^GATTACCCAGTCACCGTGGCCTCCP.JvCCTGCAG SEQ ID 50 NO :244 pMON32133.seq

GCTACACCATTGGGCCCTGCCAGvCTCCCTGCCCCAGAGCTTCCTGCTCA.^GTCTTTAGAGC.\AGTG 55 AGA.^AGATCCAGGGCGATGGCGCAGCGCTCCAGG,\GAAGCTGTGTGCCACCTAC^GCTGTGCCAC CCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCC AGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCA.\CTCCATAGCGGCCTTTTCCTCTACCAGGGG CTCCTGCAGGCCCTGGAA.GGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGAC GTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAG.\ACTGGGAATGGCCGCTGCCCTGCAG 60 CCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTT GCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCCTAC GTAGAGGGCGGTGGAGGCTCCCCGGGTGP^.CCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCT CCGTCTAAAGAATCTCATAAAT'CTCCAAACATGGCAAATCTGCAAGACGAGGAGCTGTGCGGGGGC CTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCA^\GATG 65 CAAGGCTT.GCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTCCCTTTCAGCCCCCC CCCAGCTGTCTTCGCTTCGTCCAGATCA.^CATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTG GTGGCGCTG^GCCCTGGATCACTCGCCAG.^CTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCC GACTCCTC.'vACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTCAGGG GGAGGTAGTGGTACCCAGGACTGCTCCTTCC^CACAGCCCCATCTCCTCCGACTTCGCTGTC*-iAA 70 ^TCCCTCACCTCTCTCACrACCTGCTT^GATTACCCAGTC^CCCTGGiX^ sr0 rn pMON32：73.seq 170-

O:\92\92747.DOC 200413407 GCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTCTTTAGAGCAAGTG AGA.^AGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCAC CCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCC _ AGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCC*\ACTCCATAGCGGCCTTTTCCTCTACCAGGGG 5 CTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGAC GTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCTGCCCTGCAG CCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTT GCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCCTAC GTAGAGGGCGGTGGAGGCTCCCCGGGTGA.\CCGTCTGGTCC*\ATCTCTACTATCAACCCGTCTCCT 10 CCGTCTAJ\AGAATCTCAT.^AATCTCC*\AACATGGCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC P^ACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGC CAGA.^CTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCA GGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCC TTCCAACACAGCCCCATC丁CCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTT 15 CAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGG CTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGC.^AGGCTTG CTGGAGCGCGTGAACACGGAGATACACTTTGTCACCA.^TGTGCCTTTCAGCCC SEQ ID MO:246 20 pMON35795.seq GCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTCTTTAGAGCAAGTG AGAAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCAC CCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCC 25 AGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGGG CTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGAC GTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGPu^CTGGGAATGGCCCCTGCCCTGCAG CCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTT GCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCCTAC 30 GTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCT CCGTCTA^^GAATCTCATA.^ATCTCC*\AACATGGCTCTGCAGGATGAGGAACTGTGCGGCGGCCTC TGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAA GGCTTGCTGGAGCGCGTGA^.CACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCC A.GCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTG 35 GCGCTGAAGCCCTGGATCACTCGCCAG^CTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGAC TCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTCAGGGGGA GGTAGTC-GTACCCAGGACTQCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATC CGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAAC SEQ ID M〇：247 40 PMOM35796.seq GCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTC.^AGTCTTTAGAGC^GTG AGAAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCAC 45 CCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCC AGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGGG CTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGAC GTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAG^CTGGGAATGGCCCCTGCCCTGCAG CCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTT 50 GCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCCTAC GTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATC^-ACCCGTCTCCT CCGTCTAAAGAATCTCATAAATCTCCAAACATGGCTCAAGATGAAGAGCTGTGTGGTGGTCTCTGG CGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCC.^GATGC^GGC TTGCTGGAGCGCGTGA^.CACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGC 55 TGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCG CTGA^.GCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCC TCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTCAGGGGGAGGT AGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCA.^-ATCCGT GAGCTGTCTGACTACCTGCTTCAi.GATTACCCAGTCACCGTGGCCTCCAACCTG SEQ ID 60 MO：243 pM〇M35797.seq

_ GCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTCTTTAGAGCAAGTG 65 AGAA.^GATCCAGGGCGATGGCGCAGCGCTCCAGGAG.^AGCTGTGTGCCACCTACAAGCTGTGCCAC CCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCC AGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCC.^CTCCATAGCGGCCTTTTCCTCTACCAGGGG CTCCTGCAGGCCCTGG.^AGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGAC GTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCTGCCCTGCAG 70 cccacccagggtgccatgccggccttcgcctctgctttccagcgccgggcaggaggggtcctggtt

GCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCCTAC GTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCT CCGTCTAAAGAATCTCATAAATCTCCAAACATGGCTGAAGAACTGTGTGGTGGTCTGTGGCGGCTG GTCCTGGCACAGCGCTCGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTG 75 GAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTT 171 -

O:\92\92747.DOC 200413407

CGCTTCGTCCAGACC^CATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAG CCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACC CTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGT ACCCA0GACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTG 5 不d'CTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGAC SSQ MO :249 OM0N35798.seq

10 GCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTCTTTAGAGC.^AGTG AGAAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCAC CCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCC AGCC?aGGCCCTGCAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGGG CTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGAC 15 GTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCTGCCCTGCAG CCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTT GCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCCTAC GTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCT CCGTCTAAAGA.^TCTCAT^J^ATCTCCAAACATGGCTGAGCTGTGTGGTGGCCTGTGGCGTCTGGTC 20 CTGGCACAGCGCTGGATGGAGCGGCTC^GACTGTCGCTGGGTCC.\AGATGC^J\GGCTTGCTGGAG CGCGTGAACACGGAGATACACTTTGTCACC*\AATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGC TTCGTCCAGACCA^.CATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCC TGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTC^CCCTG _ ggcggtgggtcaggaggtgggtcaggaggtggatccggaggtggctcagggggaggtagtggtacc 25 CAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCT GACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAG SEQ ID MO :250 dMON3 57 9 9.seq 30 - GCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTCTTTAGAGCA*^GTG AGAAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGPl^GCTGTGTGCCACCTACAAGCTGTGCCAC CCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCC ” AGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGGG 35 CTCCTGCAGGCCCTGG^GGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGAC GTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCTGCCCTGCAG CCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTT GCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCCTAC GTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCT 40 CCGTCTAAAGAATCTCATAAATCTCCAAACATGGCTCTGTGCGGTGGTCTGTGGCGTCTGGTCCTG GCACAGCGCTGGATGGAGCGGCTCA^.GACTGTCGCTGGGTCC^J\GATGCAAGGCTTGCTGGAGCGC GTGAP>.CACGGAGATACACTTTGTCACC^AATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTC GTCCAGACC.\ACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTG,\AGCCCTGG ATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCT'CAACCCTGGGC 45 GGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAG GACTGCTCCTTCC^CACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGAC TACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAG SEQ ID MO :251 50 pMOM39914.seq GCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTCTTTAGAGC^.GTG AGAAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCAC CCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCC 55 AGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCC^CTCCATAGCGGCCTTTTCCTCTACCAGGGG CTCCTGCAGGCCCTGGAAGGGATATCCCGCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGAC GTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGA^.CTGGGPu\TGGCCCCTGCCCTGCAG CCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTT GCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCCTAC 60 GTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCC^J\TCTCTACTATC^CCCGTCTCCT CCGTCTAAAGAATCTCATAAATCT'CCAAACATGGCTGATGAAGAACTGTGTGGTGGGCTGTGGCGG CTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC^-AGACTGTCGCTGGGXCC^-aGATGCAAGGCTTG CTGGAGCGCGTGAACACGGAGATACACTTTGTCACC.^AATGTGCCTTTCAGCCCCCCCCCAGCTGT CTTCGCTTCGTCCAGACC.^CATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTG 65 A^GCCCTGGATCACTCGCCAGA.\CTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCA ACCCTGCCGCCACCGTGGAGCCCGCGTCCACTCGGCGCCACCGCACCGACCACCCAGGACTGCTCC TTCC；^CACAGCCCCATCTCCTCCGACTTCGCTGTCA^^\TCCGTGAGCTGTCTGACTACCTGCTT CA-AGATTACCCAGTCACCGTGGCCTCC^.CCTGCAG SEQ ID MO: 252 70 pMOM39915.seq

GCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTCTTTAGAGCAP.GTG AGA.\AGATCCAGGGCGATGGCGCAGCGCTCCAGGAG.^AGCTGTGTGCCACCTAC^GCTGTGCCAC CCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCC 75 AGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCPu^CTCCATAGCGGCCTTTTCCTCTACCAGGGG 172-

O:\92\92747.DOC 200413407 CTCCTGCAGGvCCCTGG^GGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGAC GTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGG.^G.^CTGGGAATGCCCCCTGCCCTGCAG CCCACCC?aGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTT GCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCCTAC 5 GTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCC.^ATCTCTACTATCAACCCGTCTCCT CCGTCTAAAGAATCTCAT^AATCTCCAAACATGGCTGATGAAGAACTGTGTGGTGGGCTGTGGCGG CTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC^GACTGTCGCTGGGTCC.^GATGC.\AGGCTTG CTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGT CTTCGCTTCGTCCAGACC^CATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTG 10 ^GCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCA ACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGCGGTGGTTCTGGCGGAGGATCCGGCGGCGG*\AGC GGAGGTGGCTCTGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCC.^ACACAGCCCCATCTCCTCC GACTTCGCTGTCA*\AATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCC TCCAACCTGCAG SEQ ID MO :253 15 . DMON39916.seq GCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTC^AGTCTTTAGAGC^GTG AGAAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGA.\GCTGTGTGCCACCTPvCAAGCTGTGCCAC 20 CCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCG AGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCC*\ACTCCATAGCGGCCTTTTCCTCTACCAGGGG CTCCTGCAGGCCCTGGA.AGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGAC GTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGPu\CTGGGAATGGCCCCTGCCCTGCAG CCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTT 25 GCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCCTAC GTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCC.\ATCTCTACTATCAACCCGTCTCCT CCGTCTA^GAATCTCATAA.\TCTCCA.^CATGGCTGATGA^.GA.ACTGTGTGGTGGGCTGTGGCGG CTGGT'CCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGl'CGCTGGGTCCAAGATGCAAGGCTTG CTGGAGCGCGTG^J\CACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGT 30 CTTCGCTTCGTCCAGACC^CATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTG .^AGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCA ACCCTGCCGCCACCGTGGAGCCCGCGTCCACTCGGCGCCACCGCACCGACCGCTGGAC^CCGCCT CTGACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAG CTGTCTGACTACCTGCTTC^GATTACCCAGTCACCGTGGCCTCCAACCTGCAG SEQ ID 35 NO:2 5 4 * pMON3 57 12.seq 40 GCCGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGG CTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCA^.GATGCAAGGCTTG CTGGAGCGCGTGAACACGGAGATACACTTTGTCACCA^J^TGTGCCTTTCAGCCCCCCCCCAGCTGT CTTCGCTTCGTCCAGACC^.CATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTG AAGCCCTGGATCACTCGCCAG.^ACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCA 45 ACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCACCCPiGGACTGCTCC TTCCru\CACAGCCCCATCTCCTCCGACTTCGCTGTCAJ^\TCCGTGAGCTGTCTGACTACCTGCTT CPu\ SEQ ID NO ：255 DMCM3 57 13 .sea 、. 50 ‘ * GCCGCCTCC^ACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGC TGGATGGAGCGGCTC^GACTGTCGCTGGGTCCAAGATGC^-AGGCTTGCTGGAGCGCGTGP^.CACG GAGATACACTTTGTCACC.^^vTGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC _ ^CATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTG^GCCCTGGATCACTCGC 55 CAGA.nCTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTC^CCCTGGGCGGTGGGTCA ggaggtgggtcaggaggtggatccggaggtggcacccaggactgctccttcc^cacagccccatc tcctccgacttcgctgtca^atccgtgagctgtctgactacctgcttc.-j\gattacccagtcacc GTG SEQ ID NO：256 60 pMGN3 5 714.seq

GCCGTCGCTGGGTCC^GATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACC

AAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTG

. caggagacctccqagcagctggtggcgctgaagccctggatcactcgccagaacttctcccggtgc 65 CTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGT GGATCCGGAGGTGGCACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTC AAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCC.\ACCTGCAG GACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC.^G ACT 二C N〇：2 57 70 ρΜΟ：·/3 S seq

GCCT^C,^GATGC.\AGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACC；^ATGTGCC TTTCAGCCCCCCCCCAGCTGTrTTCGCTTCCTCCAGACC.\.\CATCTCCCGCCTCCTGCAGGAGACC 75 TCCGAGCAGCTGGTGGCGCTCAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTG -173 -

O:\92\92747.DOC 200413407 CAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGA GGTGGCACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGT GAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCC.^ACCTGCAGGACGAGGAG CTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCT GGG 3EQ ID NO :258 pMOM3 5716.seq GCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC^CATCTCCCGCCTCCTGCAGGAGACCTCCGAG 10 CAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGT CAGCCCGACTCCTC.^CCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGC ACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTG TCTGACTACCTGCTTC.\AGATTACCCAGTCACCGTGGCCTCC^CCTGCAGGACGAGGAGCTCTGC GGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC^GACTGTCGCTGGGTCC 15 AAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAA.\TGTGCCTTTCAG CCC SEQ ID MO :259 pM〇N35717.seq 20 GCCCGCTTCGTCCAGACCA.^.CATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTG AAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCA ACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCACCCAGGACTGCTCC TTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTT CAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGG 25 CTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCA*^GACTGTCGCTGGGTCCAAGATGCAAGGCTTG CTGGAGCGCGTGAACACGGAGATACACTTTGTCACC*^AATGTGCCTTTCAGCCCCCCCCCAGCTGT CTT SEQ ID NO:260 PMON357I3.seq 30

GCCACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCT'GGTGGCGCTGAAGCCCTGGATC ACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGT GGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCACCCAGGACTGCTCCTTCCAACACAGC ^ CCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCA

35 GTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCA CAGCGCTGGATGGAGCGGCTCAAGACT'GTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTG AACACGGAGATACACTTTGTCACC.^AATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTC CAG SEQ ID NO:261 40 pMCN32170.seq

GCTGATG^G^CTGTGTGGTGGTCTGTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC _ AAGACTGTCGCTGGGTCC^.GATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTC 45 ACCPu^ATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTC CTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGG TGCCTGGAGCTGCAGTGTCAGCCCGACTCCTC.\ACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGA GGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGv^TACCCAGGACTGCTCCTTCCAA.CACAGCCCC . ATCTCCTCCGACTTCGCTGTC^\ATCQGTGAGCTGTCTGACTACCTGCTTC^GATTACCCAGTC

50 ACCGTGGCCTCC^CCTGCAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGPu^CCGTCTGGTCCA ATCTCTACTATC^CCCGTCTCCTCCGTCT^AAG.^ATCTCAT.\.\ATCTCCAA^.CATGGCTACACCA TTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCA.^GTCTTTAGAGC*\AGTGAGAAAGATC CAGGGCGATGGCGCAGCGCTCCAGGAGPvAGCTGTGTGCCACCTAC.^AGCTGTGCCACCCCGAGGAG 〜 CTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCC 55 CTGCAGCTGGCAGGCTGCTTGAGCC^-ACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAG GCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGAC TTTGCCACCACCATCTGGCAGCAGATGGPu^G^CTGGGAATGGCCCCTGCCCTGCAGCCCACCCAG GGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCAT CTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCC SEQ ID· MO :262 PMON32137.seq

GCAGATGAA.G^CTGTGTGGGGGACTGTGGCGTCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC

AAGACTGTCGvCTGGGTCC.^GATGCAAGGCTTGCTGGAGCGCGTG.^ACACGGAGATACACTTTGTC

ACCAJ^\TGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCPu-.CATCTCCCGCCTC

CTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTG.^AGCCCTGGATCACTCGCCAGAACTTCTCCCCG

TGCCTGGAGCTCCAGTGTCAGCCCGACTCCTC^CCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGA ggtgcatcccgaggtggctcagggggaggtagtggtacccaggactgctccttcc^cacagcccc

ATCTCCTCCGACTTCGCTGTCA.\-\.^TCCGTGAGCTGTCTGACTACCTGCTTC.^AGATTACCCAGTC

ACCGTGGCCTCCA*\CCTGCAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCA

ATCTCTACTATCAACCCGTCTCCTCCGTCT.s-^AG^TCTCAT.^AATCTCC^\ACATGGCTACACCA

TTAGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCA.^GTGCTTAGAGCPu^GTGAGGAAGATC

CAGGGCCATGGCGCAGCGCTCCAGGAGA.sGCTGTGTGCCACCTACAAGCTGTGCCACCCCGAGGAG 174-

O:\92\92747.DOC 200413407

CTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCC

CTGCAGCTGGCAGGCTGCTTGAGCC.\ACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAG

GCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGAC

TTTGCGACCACCATCTGGCAGCAGATGGAAG^CTGGGAATGGCCCCTGCCCTGCAGCCCACCCAG

GGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCAT

CTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCG SEQ ID MO :263 PMOM3227I.seq 10

GCTGATGA.\GAACTGTGTGGTGGGCTGTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC AAGACTGTCGCTGGGTCC*\AGATGC.\AGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTC ACCAAATGTGCCTTTCAGCCCCCCCCCAGCT'GTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTC _ CTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGG 15 TGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGCCGCCACCGTGGAGCCCGCGTCCACTC GGCGCCACCGCACCGACCGCTGGAC*\ACCGCCTCTGACCCAGGACTGCTCCTTCC.\ACACAGCCCC ATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTa\AGATTACCCAGTC ACCGTGGCCTCCAACCTGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGGTGGTTCTGGCGGCGGC TCCAACATGGCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTC.^AGTCTTTA 20 gagcaagtgaggaagatccagggcgatggcgcagcgctccaggagaagctgtgtgccacctacaag CTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGC TCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTC TACCAGGGGCTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTG CAGCTGGACGTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGA.\CTGGGAATGGCCCCT 25 GCCCTGCAGCCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGG GTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCG CAGCCG SEQ ID NC：264 .· PMON32272.seq 30 GCTGATGAAGAACTGTGTGGTGGGCTGTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC AAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTC ACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTC ^ CTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTG^GCCCTGGATCACTCGCCAGAACTTCTCCCGG 35 TGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGC GGTCGTTCTGGCGGAGGATCCGGCGGCGGAAGCGGAGGTGGCTCTGGGGGAGGTAGTGGTACCCAG GACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAA^.TCCGTGAGCTGTCTGAC TACCTGCTTC.^AGATTACCCAGTCACCGTGGCCTCC.\A.CCTGCAGTACGTAGAGGGCGGTGGAGGC TCCCCGGGTGGTGGTTCTGGCGGCGGCTCCAACATGGCTACACCATTGGGCCCTGCCAGCTCCCTG 40 CCCCAGAGCTTCCTGCTCA^.GTCTTTAGAGC^GTGAGG^GATCCAGGGCGATGGCGCAGCGCTC CAGGAGAAGCTGTGTGCCACCTAC.^AGCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACACTCT CTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTG AGCCAJ\CTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGG^J\GGGATATCCCCC _ GAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGACTTTGCCACCACCATCTGGCAG 45 CAGATGGAAGAACTGGGAATGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCCTTCGCC TCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGGTG TCGTACCGCGTTCTACGCCACCTTGCGCAGCCG SEQ ID MO :2 65 pMOM3 227 4.seq 50 Λ

GCTGATGAAGPu^CTGTGTGGTGGGvCTGTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC AAGACTGTCGCTGGGTCCPu-.GATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTC ACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTC CTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGP«-ACTTCTCCCGG 55 TGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAP«.CCCTGCCGCCACCGTGGAGCCCGCGTCCACTC GGCGCCACCGCACCGACCACCCAGGACTGCTCCTTCC.VvCACAGCCCCATCTCCTCCGACTTCGCT GTC^^AATCCGTGAGCTGTCTGACTACCTGCTTC^AGATTACCCAGTCACCGTGGCCTCCAACCTC TACGTAGAGGGCGGTGGAGGCTCCCCGGGTGGTGGTTCTGGCGGCGGCTCC.\ACATGGCTACACCA TTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCPu^GTCTTTAGAGCA.^GTGAGR^^GATC 60 CAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCACCCCGAGGAG CTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCC CTGCAGCTGGCAGGCTGCTTGAGCC^CTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAG gccctggaagggatatcccccgagttgggtcccaccttggacacactgcAgctggacgtcgccgac

. TTTGCCACCACCATCTGGCAGCAGATGG*\AG^CTGGGAATGGCCCCTGCCCTGCAGCCCACCCAG 65 GGTGCCATGCCGGCCTTCGCCTCTGCTTTCCACCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCAT CTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCG SEQ ID MO：266 1 CMOM3 5 7 5 1.seq

GCGGAT3AGGAGCTGTGCGGTGGCCTCTGGCCGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTr ^GACTGTCGCTGGGTCC.'^GATCC.^AGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTC ACC.^-\TGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC^CATCTCCCGCCTC ” CTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAGGCCCTGGATCACTCGCCAGAACTTCTCCCGG

TGCCTGGAGCTCCAGTGTCAGCCCGACTCCTC.^ACCCTGGGCGGTGGGTCAGGAGGTGGATCCGGA -175 -

O:\92\92747.DOC 200413407

GGTACCCAGGACTGCTCCTTCC.\ACACAGCCCCATCTCCTCCGACTTCCCTGTCPvA.^-\TCCGTGAG

CTGTCTGACTACCTGCTTC^AGATTACCCAGTCACCGTGGCCTCC^CCTGCAGTACGTAGAGGGC

GGTGGAGGCT'CCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAA 一 gaatctc.vtaaatctccaaacatggctacacca/ttaggccctgccagctccctgccccagagcttc 5 CTGCTCAAGTGCTTAGAGC.^AGTGAGGAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGA.^GCTG TGTGCCACCTAC^GCTGTGCCACCCCGAGGAGvCTGGTGCTGCTCGGACACTCTCTGGGCATCCCC TGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCAACTCCAT AGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGGA-AGGGATATCCCCCGAGTTGGGTCCC ACCTTGGACACACTGCAGCTGGACGTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGG^GAA 10 CTGGG^TGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAG CGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTT CTACGCCACCTTGCGCAGCCC 3EQ ID NO:267 PMON35752.seq 15 GCCGACGAGGAGCTGTGCGGTGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC AAGACTCTCGCTGGGTCCAAGATGC.\AGGCTTGCTGGAGCGCGTGA.^CACGGAGATACACTTTGTC ACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACAT'CTCCCGCCTC CTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGG 20 TGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGA GGTGGATCCGGAGGTGGCACCCAGGACTGCTCCTTCC.^ACACAGCCCCATCTCCTCCGACTTCGCT GTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCA.^GATTACCCAGTCACCGTGGCCTCCAACCTG CAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGPvACCCTCTGGTCC^J\TCTCTACTATCAACCCG 一 TCTCCTCCGTCTAAAGAATCTCAT^AATCTCCAAACATGGCTACACCATTAGGCCCTGCCAGCTCC 25 CTGCCCCAGAGCTTCCTGCTC^GTGCTTAGAGCAAGTGAGGAAGATCCAGGGCGATGGCGCAGCG CTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACAC TCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGC TTGAGCC^CTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGG^GGGATATCC ^ CCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGACTTTGCCACCACCATCTGG 30 CAGCAGATGGAAGAACTGGGA.^TGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCCTTC GCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAG GTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCC SEQ ID ΝΟ:2β3 pMOM35753.sea 35 .

GCAGACGAGGAGCTGTGCGGTGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC AAGACTGTCGCTGGGTCC.\AGATGCA.^GGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTC ACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC^nCATCTCCCGCCTC CTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAA.GCCCTGGATCACTCGCCAGAACTTCTCCCGG 40 TGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGA GGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCC.^ACACAGCCCC ATCTCCTCCGACTTCGCTGTC^-AAATCCGTGAGCTGTCTGACTACCTGCTTC^aAGATTACCCAGTC ACCGTGGCCTCC.\ACCTGCAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGA^\CCGTCTGGTCCA ATCTCTACTJVTCAACCCGTCTCCTCCGTCTAAAGAATCTCA.TAAATCTCCAAACATGGCTACACCA 45 TTAGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTGCTTAGAGC^GTGAGG^.GATC

CAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCACCCCGAGGAG CTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCC CTGCAGCTGGCAGGCTGCTTGAGCCPvACTCCATAGvCGGCCTTTTCCTCTACCAGGGGCTCCTCCAG _ GCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGAC 50 TTTGCCACCACCATCTGGCAGCAGATGG^GA-^CTGGG^TGGCCCCTGCCCTGCAGCCCACCCAG GGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCAT CTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTGTACGCCACCTTGCGCAGCCC 3EQ ID MO :269 55 DMCN35754.seq GCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC.^CATCTCCCGCCTCCTGCAGGAGACCTCCGAG CAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAG^CTTCTCCCGGTGCCTGGAGCTGCAGTGT CAGCCCGACTCCTC.^ACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGC 60 ACCCAGGACTCCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTC；-^vATCCGTGAGCTG TCTGACTACCTGCTTCA^.GATTACCCAGTCACCGTGGCCTCCA-^CCTGCAGGACGAGGAGCTCTGC GGGGGCCTCTGGCGGCTGGTCCTGGCACAGvCGCTGGATGGAGCGGCTC^GACTGTCGCTGGGTCC ^GATGC^GGCTTGCTGGAGCGCGTG^CACGGAGATACACTTTGTCACC.-^TGTGCCTTTCAG _ CCGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCC.-vATCTCTACTATC.^CCCG 65 TCTCCTCCCTCT.^^AGA^TCTCATA^^TCTCC.^^CATGGCTACACCATTAGGCCCTGCCAGCTCC GTGCCCCAGAGCTTCCTGCTCP^GTGCTTAGAGvC.^-.GTGAGGAAGATCCAGGGCGATGGCGCAGCG CTCCAGGAG^GCTGTGTGCCACCTAC^GCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACAC TCTCTCGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGC ^ TTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGG；^GGGATATCC 70 CCCGAGTTGvGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGACTTTGCCACCACC.^TCTGG CAGCAGATGGA^.G^CTGGGA.\TGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCCTTC GCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAG GTGTCGTACCGCGTTATACGCCACCTTGCGCAGCCC 3EQ ID MO：270 75 pMOM3S?S5.3-q 176-

O:\92\92747.DOC 200413407 gcttc4\aatctgcaggatg*\agagctgtgcgggggcctctggcggctggtcctggcacagcgctgg ATGGAGCGGCTC.^AGACTGTCGCTGvGGTCCAAGATGC^GGCTTGCTGGAGCGCGTGAACACGGAG ATACAC-TTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAAC 5 ATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAG AJ\CTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGA GGTGGGTCAGGAGGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTC CAACACAGCCCCATCTCCTCCGACTTCGCTGTC^\ATCCGTGAGCTGTCTGACTA-CCTGCTTCX\ GATTACCCAGTCACCGTGGCCTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCA 10 ATCTCTACTATCAACCCGTCTCJVTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCTACACCA TTAGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTC.\AGTGCTTAGAGC.^AGTGAGGAAGATC CAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCACCCCGAGGAG CTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCC CTGCAGCTGGCAGGCTGCTTGAGCC^CTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAG 15 GCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGAC TTTGCCACCACCATCTGGCAGCAGATGG.^AGAACTGGGAATGGCCCCTGCCCTGCAGCCCACCCAG GGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCAT CTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCC SEQ ID NO:271 20 PMON35756.seq GCTAATCTGCAAGATGAGGAGCTGTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACi\GCGCTGGATG GAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGA-ACACGGAGATA 25 CACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCPu^CATC TCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAAC TTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGT GGGTCAGGAGGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCC.^A CACAGCCCCATCTCCTCCGACTTCGCTGTCAA^-ATCCGTGAGCTGTCTGACTACCTGCTTC^GAT 30 TACCCAGTCACCGTGGCCTCCTACGTAC-AGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCA ATCTCTACTATC^CCCGTCTCCTCCGTCTAAAGAATCTCAT^^TCTCCAAACATGGCTACACCA TTAGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTGCTTAGAGCAAGTGAGGAAGATC CAGGGCGATGGCGCAGCGCTCCAGGAGAP«.GCTGTGTGCCACCTACAAGCTGTGCCACCCCGAGGAG • CTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCC 35 CTGCAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAG GCCCTGG^GGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGAC TTTGCCACCACCATCTGGCAGCAGATGGAAGAACT'GGGAATGGCCCCTGCCCTGCAGCCCACCCAG GGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCAT CTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTATACGCCACCTTGCGCAGCCC SEQ ID 40 MO:272 pMOM3 5 7 57.seq ^ GCGCTGCAGGATGAAGAGCTGTGTGGCGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTTGATGGAG 45 CGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACAC TTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCWACATCTCC CGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTC TCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGG TCAGGAGGTGGATCCGGAGGTGGCTCAQGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCC^CAC 50 AGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCP-JkGATTAC CCAGTCACC3TGGCCTCC.\ACTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCA ATCT'CTACTATCAACCCGl'CTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCTACACCA TTAGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTC.^.GTGCTTAGAGC.^GTGAGGP>^GATC CAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTAC^GCTGTGCCACCCCGAGGAG 53 CTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCC CTGCAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAG GCCCTGGA.^GGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGAC TTTGCCACCACCATCTGGCAGCAGATGGA.nGA^CTGGG1\ATGGCCCCTGCCCTGCAGCCCACCCAG GGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCAT 60 CTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCC SEQ ID NO :273 pMOM35758.seq

65 GCACTGTGCGGTCGTCTGTGGCGTCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC.\AGACTGTC GCTGGGTCC.V\GATGC.^AGGCTTGCTGGAGCGCGTG4^ACACGGAGATACACTTTGTCACCA^^TGT GCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC^CATCTCCCGCCTCCTGCAGGAG ACCTCCGAGCAGCTGGTGGCGCTG^GCCCTGGATCACTCGCCAG^CTTCTCCCGGTGCCTGGAG CTACAGTGTCAGCCCGACTCCTC^CCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCC 70 GGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTCCTCCTTCCAACACAGCCCCATCTCCTCC GACTTCGCTGTC.Wv\TCCGTOAGCTGTCTGACTACCTGCTTC^GATTACCCAGTCACCGTGGCC TCC^CCTCCAGGACGAGGAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTG^CCGTCTGGTCCA ATCTCTACTATCAACCC.CrrC'rCCTCCGTCTAAAGAATCTC-VTAAATCTCCAAACATGGCTACACCA TTAGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTC.^GTGCTTAGAGCAAGTGAGG/vAGATC 75 CAGGC.CGArGGCGCAGCGCTCCAGCAGAAGCTGTGTGCCACCTAC.^AGCTGTGCCACCCCGAGGAG 177-

O:\92\92747.DOC 200413407 CTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTCCCCCAGCCAGGCC CTGCAGCTGGCAGGCTGCTTGAGCC.\ACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAG GCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGAC TTTGCCACCACCATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCTGCCCTGCAGCCCACCCAG 5 GGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCAT CTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCC 3EQ ID NO :27 4 ΌΜΟΝ35759.seq to GCCTCCAAGATGC.^AGGCTTGCTGGAGCGCGTG^CACGGAGATACACTTTGTCACCA*\ATGTGCC TTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC^CATCTCCCGCCTCCTGCAGGAGACC TCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTG CAGTGTCAGCCC+GACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGA 15 GGTGGCACCCAGGACTGCTCCTTCC.\ACACAGCCCCATCTCCTCCGACTTCGCTGTCA.\AATCCGT GAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCC.\ACCTGCAGGACGAGGAG CTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCA-^GACTGTCGCT GGCTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCC^TCTCTACTATCAACCCG TCTCCTCCGTCTAAAGAATCTCAT^^ATCTCCAAACATGGCTACACCATTAGGCCCTGCCAGCTCC 20 CTGCCCCAGAGCTTCCTGCTCAAGTGCTTAGAGCAAGTGAGGAAGATCCAGGGCGATGGCGCAGCG CTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACAC TCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGC TTGAGCCA-^CTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGG^GGGATATCC CCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGACTTTGCCACCACCATCTGG 25 CAGCAGATGGA.\GAACTGGGAATGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCCTTC GCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAG GTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCC SEQ ID MO :275 pMOM3 57 5 0. sea 30 ▲ GCCTCCAAGATGC.^AGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACC^J^TGTGCC TTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACC TCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTG CAGTGTCAGCCCGACTCCTC^ACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGA 35 GGTGGCACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGT GAGCTGTCTGACTACCTGCTTC^GATTACCCAGTCACCGTGGCCTCC^CCTGCAGGACGAGGAG CTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCT GGCTACGTAGAGGGCGGTGGAGGCTCCCCGGGTG^ACCGTCTGGTCCAATCTCTACTATCAACCCG TCTCCTCCGTCTAAAGAATCTCAT^^TCTCCA>^CATGGCTACACCATTAGGCCCTGCCAGCTCC 40 CTGCCCCAGAGCTTCCTGCTCAAGTGCTTAGAGC^GTGAGGAAGATCCAGGGCGATGGCGCAGCG CTCCAGGAGAAGCTGTGTGCCACCTAC^GCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACAC TCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGC TTGAGCC.^ACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGGAAGGGATATCC CCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGACTTTGCCACC^CCATCTGG 45 CAGCAGATGGAAGAACTGGGAATGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCCTTC GCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAG GTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCC SEQ ID MO: 27 5 pMON35761.seq > 50

GCGCTGTGTGGTGGTCTGTGGCGTCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC^GACTGTC GCTGGGTCC.-AGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACC^-ATGT GCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC^CATCTCCCGCCTCCTGCAGGAG … ACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGA^.CTTCTCCCGGTGCCTGGAG 55 CTGCAGTGTCGGCCCGACTCCTC^CCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCC GGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCC.^CACAGCCCCATCTCCTCC .\ACTTCGCTGTC.\AGATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCC TCC^CCTGCAGGACGAGGAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCA ATTTTTACTATC^CCCGTCTCCTCCGTCT.\.^G^TCTCAT^ATCTCC^^CATGGCTACACCA 60 TTAGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTC^GTGCTTAGAGCAAGTGAGGP>-AGATC CAGGGCGATGGCGCAGCGCTCCAGGAG^GCTGTGTGCCACCTACAAGCTGTGCCACCCCGAGGAG CTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTC.CTGCCCCAGCCAGGCC CTGCAGCTGGCAGGCTGCTTGAGCC^CTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAG 舞 gccctgg.-^gggatatcccccgagttgggtcccaccttggacacactgcagctggacgtcgccgac 65 TTTGCCACCACCATCTGGCAGCAGATGGA^.G^CTGGGAATGGCCCCTGCCCTGCAGCCCACCCAG GGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCAT CTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCC SSQ ID NO :2 7 7 70 Df40M3STi： .seq gctgaact^tgtggtggtctgtggcgtctggtcctggcacagcgctggatggagcggctc^gact gtccctcggtcc.^.gatgca.^ggcttgctggagcgcgtg.^acacggagatacactttgtcacc^\a

TGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC^CATCTCCCGCCTCCTGCAG 75 GAGACCTCCC-AGCAGCTGGTGGCGCTG^GCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTG -178-

O:\92\92747.DOC 200413407 GAGCTGCAGTGTCAGCCCGACTCCTC.^CCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGA TCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCC.\ACACAGCCCCATCTCC TCCGAC^TCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTG GCCTCC^CCTGCAGGACGAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTG^CCGTCTGGTCCA 5 ATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCTACACCA TTAGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTC^3TGCTTAGAGC*\AGTGAGGA^GATC CAGGGCGATGGCGCAGCGCTCCAGGAGPu\GCTGTGTGCCACCTAC.\AGCTGTGvCCACCCCGAGGAG CTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCC CTGCAGCTGGCAGGCTGCTTGAGCCA.\CTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAG 10 GCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGAC TTTGCCACCACCATCTGGCAGCAGATGG.\AGAACTGGGAATGGCCCCTGCCCTGCAGCCCACCCAG GGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCAT CTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCC SEQ ID NO:278 15 pMON3 57 6 3.seq

GCTGAAGAACTC-TGT'GGTGGCCTGTGGCGGCTGGTCCTGGCACAGCGCTGC'VTGGAGCGGCT'CAAG ACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACC 20 AAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC^CATCTCCCGCCTCCTG CAGGAGACCTCCGAGCAGCTGGTGGCGCTGA^.GCCCTGGATCACTCGCCAGA.\CTTCTCCCGGTGC CTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGT GGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCC*\ACACAGCCCCATC TCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTC^J\GATTACCCAGTCACC 25 GTGGCCTCC^CCTGCAGGACTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGvGTCCA ATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCTACACCA TTAGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTGCTTAGAGC.^GTGAGGAAGATC CAGGGCGATGGCGCAGCGCTCCAGGAG^.GCTGTGTGCCACCTACAAGCTGTGCCACCCCGAGGAG ^ CTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCC 3〇 CTGCAGCTGGCAGGCTGCTTGAGCC.^CTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAG GCCCTGG^GGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGAC TTTGCCACCACCATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCTGCCCTGCAGCCCACCCAG GGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCAT CTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCC S5Q ID 35 pMON3 576 4.seq

GCTCAGGACGAGGAACTGTGTGGTGGTCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGG 40 CTC^J\GACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTT

GTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCA.iCATCTCCCGC CTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTG^GCCCTGGATCACTCGCCAGA-^CTTCTCC CGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTC^\CCCTGGGCGGTGGGTCAGGAGGTGGGTCA _ GGAGGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCC*\ACr\CAGC 45 CCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCA GTCACCGTGGCCTCCAACCTGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCA ATCTCTACTATCAACCCGTCTCCTCCGTCTAAAG^TCTCATAAATCTCC^AACATGGCTACACCA TTAGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTGCTTAGAGC.^GTGAGGAAGATC _ CAGGGCGATGGCGCAGCGCTCCAGGAGA^.GCTGTGTGCCACCTACAAGCTGTGCCACCCCGAGGAG

50 CTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCC CTGCAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAG GCCCTGG^GGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGAC TTTGCCACCACCATCTGGCAGCAGATGGAAGAACTGGG^TGGCCCCTGCCCTGvCAGCCCACCCAG • GGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCAT CTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCC SEQ ID MO :230 pMON3 57 5 5.seq

60 GCCACC^CATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATC

ACTCGCCAG^CTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTC^CCCTGGGCGGT GGGTC；vGGAGGTGGGTCAGr；AGGTGGATCCGGAGGTGGCACCCAGGACTGeTCCTTCCAACACAGC cccatctcctcccactttgctgtc.\a.^tccgtgagctgtctgactacctgcttca^gattaccca gtcaccctggcctccaacctgcaggacgaggagctctgcgggggcctctggcggctggtcctggca

55 CAGCGCTGGATGGAGCGGCTC^GACTGTCGCTGGGTCCA.-XGATGC.^AGGCTTGCTGGAGCGCGTG

AACACGGAGATACACTTTGTCACC.V^TGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTC CAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTG.\ACCGTCTGGTCCA.^TCTCTACTATC^CCCG TCTCCTCCGTCTA^GAATCTCATA.^ATCTCC.\A.^CATGGCTACACCATTAGGCCCTGCCAGCTCC ctgccccagagcttcctgctc.\agtgcttagagc^gtgago^gatccaoggcgatggcgcagcg

CTCCACGAG^GCTGTGTGCCACCTAC^GCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACAC

TCTCTGGGvCATCCCCTOGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTGv^AGCTGGCAGGCTGC

TTGAGCC.^.CTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTCC3A.AGGGATATCC cccgagttgggtcccaccttggacacactgcagctggacgtcgccgactttgccaccaccatctgg

CAGCAGATGGAAGAACTGGGAATGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCCTTC -179-

O:\92\92747.DOC 200413407 GCCTCTCCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAG GTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCC SEQ ID MO :281 ^ ? HON 3 5 7 6 5.s eq/pMON 3 2 19 0.s eq/pMOM 4 0 0 01.3 eq GCTGATGAAG.^CTGTGTGGTGGTCTGTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC ^GACTGTCGCTGGGTCC.\AGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTC ACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC^-ACATCTCCCGCCTC CTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAG^CTTCTCCCGG ! 0 TGCCTGGAGCTGCAGTGTCAGCCCGACTCCTC.^ACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGA GGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCC.\ACACAGCCCC ATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTC.^GATTACCCAGTC ACCGTGGCCTCC.V\CCTGCAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGGTGGTTCTGGCGGC GGCTCC.^CATGGCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTC^AGTCT 15 TTAGAGC^GTGAGAAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTAC AAGCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTG AGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTC CTCTACCAGGGGCTCCTGCAGGCCCTGG^GGGATATCCCCCGAGTTGGGTCCCACCTTGC-ACACA CTGCAGCTGGACGTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGA^.GA-ACTGGG.^ATGGCC 20 CCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGA GGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTT GCGCAGCCG 5HQ ID NO：232 OM0M35758.seq GCTC.\AGATGAAG^CTGTGCGGTGGTCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGG CTC^GACTGTCGCTGGGTCC*\AGATGC^J\GGCTTGCTGGAGCGCGTGr.AC.^CGGAGATACACTTT GTCACC^JVTGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCA^.CATCTCCCGC CTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCC CGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCA GGAGGCGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCC^CACAGC CCCATCTCCTCCGACTCCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTC^J\GATTACCCA GTCACCGTGGCCTCCAACCTGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCA ATCTCTACTATQ.v.CCCGTCTClTCCGTCT^G^TCTCAT^TCTCC^aCATGGCTACACCA TTAGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTGCTTAGAGCAAGTGAGGAAGATC CAGGGCGATGGCGCAGCGCTCCAGGAG.^AGCTGTGTGCCACCTAC.\AGCTGTGCCACCCCGAGGAG CTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCC CTGCAGCTGGCAGGCTGCTTGAGCC.-J\CTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAG GCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGAC tttgccaccaccatctggcagcagatggaagaactgggaatggcccctgccctgcagcccacccag GGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCAT CTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCC ScQ ID NO :2 3 3 25 30 35 40 45 pMCN3577〇.seq GCGCTGTGTGGTGGCCTGTGGCGTCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC^GACTGTC GCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATAT GCCTTTCAGCCCCCCCCCAGCTGTCT^CGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAG 50 ACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAG CTGCAGTGTCGGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTCA GGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTC Pu^GATCCGTGAGCTGTCTGACTACCTGCTTCA-AGATTACCCAGTCACCGTGGCCTCCA^.CCTGCAG GACGAGGAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGA^\CCGTCTGGTCCA.^TCTCTACTATC 55 .^CCCGTCTCCTCCGTCT^^G^.TCTCAT^A^.TCTvCC^^CATGGCTACACCATTAGGCCCTGCC AGCTCCCTGCCCCAGAGCTTCCTGCTCAu\GTGCTTAGAGCAAGTGAGGAAGATCCAGGGCGATGGC GCAGCGCTCCAGGAG^.GCTGTGTGCCACCTACAAGCTGTGCCACCCCGAGGAGCTGGTGCTGCTC GGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCA GGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGG^.GGG 60 ATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGACTTTGCCACCACC ATCTGGCAGCAGATGG^GAACTGGGAATGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCG GCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTC CTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCC SEQ ID MO:284

65 OM0N357"：.seq GCCTCC^.GATCtC.^AGGCTTGCTGGAGCGCGTG^CACGGAGATACACTTTGTCACC.^^ATGTGCC TTTCr\GCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC^CATCTCCCCCCTCCTGCAGGAGACC TCCGAGCAGCTGGTGGCGCTC.^GCCCTGGATCACTCGCCAGAACTTCTTCCGGTGCCTGGAGCTG 70 CAGTGTCAGCCCGACTCCTC^CCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGA GGTGGCACCCAGGACTGCTCCTTCC.^CACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGT GAGCTGTCTGACTACCTGCTTC.\AGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAG rTCTGrGr.GGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC^GACTGTCGCT ggctacgtagagggcggtggaggctccccgggtgaaccgtctggtcc.^atctctactatc^cccg 75 TCTCCTCCGTCTA.\AG^TCTCATAA.ATCTCC-^CATGGCTACACCATTACGCCCTGCCAGCTCC

O:\92\92747.DOC 180- 200413407 CTGCCCCAGAGCTTCCTGCTC.^AGTGCTTAGAGC^GTGAGG.^GATCCAGGGCGATGGCGCAGCG CTCCAGGAGPu^GCTGTGTGCCACCTAC^GCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACAC TCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGC TTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGGA--\GGGATATCC 5 CCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGACTTTGCCACCACCATCTGG CAGCAGATGGAAGPu\CTGGGAATGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCCTTC GCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAG GTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCC ScQ ID MO :28 5 10 pMON3 57 7 3.seq

GCTCAAGACGAAGAACTGTGTGGTGGTCTCTGGCGGCTCGTCCTGGCACAGCGCTCGATGGAGCGG CTC^AGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTT GTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGC 15 CTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCC CGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCA GGCGGTGGTTCTGGCGGAGGATCCGGCGGCGGAAGCGGAGGTGGCTCTGGGGGAGGTAGTGGTACC CAGGACTGCTCCTTCC.\ACACAGCCCCATCTCCTCCGACTTCGCTGTCAA.^ATCCGTGAGCTGTCT GACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCC.^ACCTGTACGTAGAGGGCGGTGGAGGC 20 TCCCCGGGTG^CCGTCTGGTCC^.ATCTCTACTATC.\ACCCGTCTCCTCCGTCTAAAGAATCTCAT AAATCTCCAAACATGGCTACACCATTAGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTC.\AG TGCTTAGAGCAAGTGAGG^GATCCAGGGCGATGGCGCAGCGCTCCAGGAG^GCTGTGTGCCACC TACAAGCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCC CTGAGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTT 25 TTCCTCTACCAGGGGCTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGAC ACACTGCAGCTGGACGTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGG^.GA-^CTGGGAATG GCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCA GGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCAC CTTGCGCAGCCC SEQ ID MO :236 30 pMCM3 57 77.seq

GCCCAAGATGAAGAACTGTGTGGTGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGG CTCAAGACTGTCGCTGGGTCCAAGATGC.^-AGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTT 35 GTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGC CTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGA-.CTTCTCC CGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTC.^ACCCTGCCGCCACCGTGGAGCCCGCGTCCA CTCGGCGCCACCGCACCGACCACCCAGGACTGCTCCTTCCA-^CACAGCCCCATCTCCTCCGACTTC GCTGTCAA^J\TCCGTGAGCTGTCTGACTACCTGCTTC.^GATTACCCAGTCACCGTGGCCTCCAAC 40 CTGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCA.^CCCG TCTCCTCCGTCTPlAAGAATCTCATAAATCTCCAAACATGGCTACACCATTAGGCCCTGCCAGCTCC CTGCCCCAGAGCTTCCTGCTCAAGTGCTTAGAGCAAGTGAGGAAGATCCAGGGCGATGGCGCAGCG CTCCAGGAGA^GCTGTGTGCCACCTACAAGCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACAC TCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGC 45 * TTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGG^GGGATATCC CCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGACTTTGCCACCACCATCTGG CAGCAGATGGAAGAACTGGGAATGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCCTTC GCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAG GTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCC SEQ ID NO :287

50 OM0M35773.seq 60 65 70 GCCC^GATG.-.AGAACTGTGTGGTGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGG CTC^GACTGTCGCTGGGTCC^GATGC；^GGCTTGCTGGAGCGCGTGAACACGGAGATACACTTT GTCACC^\TGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC*\.nCATCTCCCGC L. 1 ' -w λ I jl i i 'vw-rvL· ^ ^ ^ CGGTGCCTCGAGCTGCAGTGTCAGCCCGACTCCTCA^.CCCTGCCGCCACCGTGGAGCCCGCGTCCA CTCGGCGCCACCGCACCGACCGCTGGAC.^CCGCCTCTGACCCAGGACTGCTCCTTCC^CACAGC CCCATCTCCTCCGACTTCGCTGTCA^J^TCCGTGAGCTGTCTGACTACCTGCTTC.^AGATTACCCA GTCACCGTGGCCTCCA^.CCTGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCA ATCTCTACT'ATCAACCCGTCTCCl'CCGTCTAAAGAATCTCATAAATCT'CCAAACJVTGGCTACACCA TTAGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTGCTTAG^GC^GTGAGGA.-\GATC CAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTAC.\AGCTGTGCCACCCCGAGGAG CTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCC CTGCAGCrGGCAGGCTGCTTGAGCCAACTCCATAGCGGvCCTTTTCCTCTACCAGGGGCTCCTGCAG GCCCTGG^GGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGAC TTTGCCACCACCATCTGGCAGCAGATGGAAGA.^CTGCG^TGGCCCCTGCCCTGCAGCCCACCCAG GGTGCCATGCCCGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCAT CTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTPvCGCCACCTTGCGCAGCCC SEQ 二3MO：239 pMON3 5 7~'9 . 3eq GCTGATG.^G；vACTGTGTGGTGGGCTGTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC 75 .\.\gactgtcgctgggtccx^gatgcaaggcttgctggagcgcgtga.^cacggagatacactttgtc 181 -

O:\92\92747.DOC 200413407 ACCA/vATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC.^CATCTCCCGCCTC CTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGG TGCCTGGAGCTGCAGTGTCAGCCCGACTCCTC.\ACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGC — GGTGGTTCTGGCGGAGGATCCGGCGGCGGAAGCGGAGGTGGCTCTGGGGGAGGTAGTGGTACCCAG 5 GACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTC.\AAATCCGTGAGCTGTCTGAC TACCTGCTTC^GATTACCCAGTCACCGTGGCCTCC.^ACCTGCAGTACGTAGAGGGCGGTGGAGGC TCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCAT AAATCTCCAAACATGGCTACACCATTAGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAG TGCTTAGAGCAAGTGAGGAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACC 10 TACAAGCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCC CTGAGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTT TTCCTCTACCAGGGGCTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGAC ACACTGCAGCTGGACGTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAG^CTGGGAATG GCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCA 15 GGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCQTACCGCGTTCTACGCCAC CTTGCGCAGCCC SEQ ID NO :239 pMOM35730.seq

20 GCTGATGAP..GAACTGTGTGGTGGGCTGTGGCGGCTGGTCCT3GCACAGCGCTGGATGGAGCGGCCC AAGACTGTCGCTGGGTCCA.\GATGC^GGCTTGCTGGAGCGCGTGA-ACACGGAGATACACTTTGTC ACC^*AATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCP>^CATCTCCCGCCTC CTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGG TGCCTGGAGCTGCAGTGTCAGCCCGACTCCTC.^ACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGC 25 GGTGGTTCTGGCGGAGGATCCGGCGGCGGAAGCGGAGGTGGCTCTGGGGGAGGTAGTGGTACCCAG GACTGCTCCTTCCAACACAGCCCCATCTC'CTCCGACTTCGCTGTCAAA^.TCCGTGAGCTGTCTGAC TACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGTACGTAGAGGGCGGTGGAGGC TCCCCGGGTGAJ\CCGTCTGGTCCAATCTCTACTATC.\ACCCGTCTCCTCCGTCTAA^.GAATCTCAT AAATCTCCAAACATGGCTACACCATTAGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTC^G 30 TGCTTAGAGCAAGTGAGGAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAG^GCTGTGTGCCACC TACAAGCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATGCCCTGGGCTCCC CTGAGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCC*\ACTCCATAGCGGCCTT TTCCTCTACCAGGGGCTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGAC ACACTGCAGCTGGACGTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGAACTGGGAATG 35 GCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCA GGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCAC CTTGCGCAGCCC SEQ IID N〇：2 90 pMCM3S782.seq 40

QCGGACGAGGAGCTGTGCGGTGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC AAGACTGTCGCTGGGTCCA.^GATGCAAGGCTTGCTGGAGCGCGTG^CACGGAGATACACTTTGTC ACCAA^\TGTCCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCA.^CATCTCCCGCCTC CTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCrCTGGATCACTCGCCAGAACTTCTCCCGG 45 TGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGCCGCCACCGTGGAGCCCGCGTCCACTC GGCGCCACCGCACCGACCGCTGGACAACCGCCTCTGACCCAGGACTGCTCCTTCCAACACAGCCCC ATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTC^GATTACCCAGTC ACCGTGGCCTCCAACCTGCAGTACGTAGAGGGCGGTGGAGGCACCCCGGGTGAACCGTCTGGTCCA ATCTCTACTATCAACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTTCC.^AACATGGCTACACCA 50 TTAGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTC.^.GTGCTTAGAGC^GTGAGGAAGATC CAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCPvCCTAC.^GCTGTGCCACCCCGAGGAG CTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCC CTGCAGCTGGCAGGCTGCTTGAGCCPvACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAG GCCCTGG^GGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGAC

C «C rpmrp广、·一内 '广广* ' «Τ' 广》"Π广♦ 〇 ' ' 广、、、广、，广' 、rr»广广广叫^ 内广 ' P J J L· L X. L ·Ί Η 上·ν- i od ,ό、一*k i ^V一 w ▲ jv* 一 V-1 •一,w GGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCAT CTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCC S£Q ID NO：29i 60 pMOM3990S.seq

GCTGATGAGGAGCTGTGTGGTGGTCTGTGGCGGCTGGTCCTGGCACAGCQCTGGATGGAGCGGCTC AAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTC ACCA^^.TGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTC 65 CTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAG^CTTCTCCCGG TGCCTGGAGCTGCAGTGTCAGCCCGTAGAGACGGTGTTTCACCGTGTCAGCCAGGATGGTCTAGAT CTCCTGACCTCGACCCAGGACTGCTCCTTCC^CACAGCCCCATCTCCTCCGACTTCGCTGTC.^^ ATCCGTGAGCTGTCTGACTACCTGCTTC.\AGATT^CCCAGTCA：CGTGGCCTCC.\ACCTGCAGTAC GTAGAGGGCGGTGGAGGCTCCCCGGGTGGTGGTTCTGGCGGCGGCTCCAACATGGCTACACCATTG 70 GGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTC.\AGTCTTTAGAGCAJ\GTGAG^-.GATCCAG GGCGA?GGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACT^C^Gv?TGTGCCACCCCGAGGAGCTG GTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTG CAGCTGGCAGGCTGCTTGAGCC.-^CTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCC CTGG^GGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGACTTT 75 GCCACCACCATCTGGCAGCAGATGGAAG^-ACTGGGAATGGCCCCTGCCCTGCAGCCCACCCAGGGT

O:\92\92747.DOC -182- 200413407 GCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCATCTG CAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCG SEQ ID MO :292 5 pMON32275.seq

GCTGATG.^AG^CTGTGTGGTGGGCTGTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC AAGACTGTCGCTGGGTCC.\AGATGCA^.GGCTTGCTGGAGCGCGTGA^CACGGAGATACACTTTGTC ACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC^.CATCTCCCGCCTC 10 CTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTG.\AGCCCTGGATCACTCGCCAGA.\CTTCTCCCGG TGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGTACGTAGAGGGCGGTGGAGGCTCCCCG GGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAA.^GAATCTCATAAA.TCT CCAAACATGGCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTCTTTA . GAGCAAGTGAGAAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGT'GTGCCACCTACAAG 15 CTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGC TCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTC TACCAGGGGCTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTG CAGCTGGACGTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCT GCCCTGCAGCCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGG 20 GTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCG CAGCCCTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCC^TCTCTACTATCAAC CCGTCTCCTCCGTCTAAAG 从 TCTCAT^ATCTCCAAACATGGCAACCCAGGACTGCTCTTTTCAA CACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTC*\AGAT _ TACCCAGTCACCGTGGCCTCCAACCTGCAG SEQ ID MO:293 pMON35781.seq

GCCACCCAGGACTGCTCCTTTCA^.CACAGCCCCATCTCCTCCGACTTCGCTGTC^^ATCCGTGAG ctgtctgactacctgcttcaagattacccagtcaccgtggcctccaacctgcaggagccgaagagc

CCGGACACCCATACTAGTCCGCCATCTCCGACACCATTAGGCCCTGCCAGCTCCCTGCCCCAGAGC TTCCTGCTCAAGTCTTTAGAGCAAGTGAGA^J\GATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAG CTGTGTGCCACCTACAAGCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATC ^ . CCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCA.\CTC J：> CATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGC CCCACCTTGGACACACTGCAGCTGGACGTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGG^J\ GAACTGGGA^.TGGCCCCTGCCCTGCACCCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTC CAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGC GTTCTACGCCACCTTGCGCAGCCCTCTGCAGAACCGAAATCTCCGGATACTCATACCAGCCCGCCA tccccgggttctaXtctgcaagatgaagagctgtgcgggggcctctggcggctggtcctggcacag CGCTGGATGGAGCGGCTC.^AGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAAC ACGGAGATACACTTTGTCACC^^ATGTGCCTTTCAGCCCCCCCCCAGCTCxCCTTCGCTTCGTCCAG ACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGP-^GCCCTGGATCACT CGCCAG.^CTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTG SEQ ID 45 MO:294 PMON35783.seq 50 55 60 65 GCCACCCAGGACTGCTCCTTTCAACAQAGCCCCATCTCCTCCGACTTCGCTGTC^^AATCCGTGAG CTGTCTGACTACCTGCTTC.^GATTACCCAGTCACCGTGGCCTCCAACCTGCPvGGACGAGGAGCTC tgcgggggcctctggcggctggtcctgc7cacagcgctggatggagcggctca.\gactgtcgctggg TCC^GATGC^GGCTGGCAGGGGCGCGTGAACACGGAGATACACTTTGTCACCAA.^TGTGCCTTT CCGAAGAGCCCGGACACCCATACTAGTCCGCCATCTCCGGGTACACCATTGGGCCCTGCCAGCTCC CTGCCCCAGAGCTTCITGCTCA^.GTCTTTAGAGCA^.GTGAG.^AAGATCCAGGGCGATGGCGCAGCG CTCCAGGAG^.GCTGTGTGCCACTAC^GCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACACT CTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCT TGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTGGAAGGGATATCCC CCGAGTTGGGTCCCACCTTGGACACACTGvCAGCTGGACGTCGCCGACTTTGCCACCACCATCTGGC AGCAGATGG^.G^CTGGGAATGGCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCCTTCG CCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGG TGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCCTCTGCAGAACCGAAATCTCCGGATACTCATA CCAGCCCGCCATCCCCGGGTAAGGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCA ACATCTCCCGCCTCvCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCC AGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTG SEQ ID NO:295

OC40M3 2 5 . 〇eq

GCTGaTC.^,〇AACTGTGTCGTGGTCTGTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC

A.^GACTGTC3CTGGGTCC.\AGATGC^.GGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTC

ACC.V-vATC'rGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC.^ACATCTCCCGCCTC

CTGCAGGAGAvl'CTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGG

TGCCTGGAGCTGCAGTGTCAGCCCGACTCCTC.-^CCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGA

GGTGGATCC-JCAGGTGGvCTCAGGGGGAGGTAGTGGTACCCAGGACTCCTCCTTCC.^ACACAGCCCC -183 -

O:\92\92747.DOC 200413407 pMON3 9 906.seq GCCACTCAGGACTGTTCTTTTCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAA.^TCCGTGAG CTGTCTGACTACCTGCTTC.\AGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTC 5 TGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC^GACTGTCGCTGGG TCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTT'TGTCACCAAATGT'GCCTT'T CAGCCCCCCCCCAGCTGTvCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCC GAGCAGCTGGTGGCGCTGPu^GCCCTGGATCACTCGCCAGAACTTCTCCCGGCGCCTGGAGCTGCAG TCTCAGCCCGACTCCTCAACCCTGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGGTGGTTCTGGC 10 GGCGGCTCCAACATGGCTACACCATITGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAG TCTTTAGAGC.\AGTGAGAAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACT AACAAGCTCTGCCACCCCGA.GGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCC CTGAGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCC^CTCCATAGCGGCCTT TTCCTCTACCAGGGGCTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGAC 15 ACACTGCAGCTGGACGTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGPu\G^CTGGGAATG GCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCA GGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCAC CTTGCGCAGCCG SEQ ID MO :3 04 20 pM〇N399〇9.seq

GCTGATGAAG^.CTGTGTGGTGGTCTGTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC AAGACTGTCGCTGGGTCCAAGAT'GCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTC ACC.\AATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCA^.CATCTCCCGCCTC 25 CTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGG TGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGA GGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCC ATCTCCTCCGACTTCGCTGTC^^ATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTC ACCGTGGCCTCCAACCTGCAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGGTGGTTCTGGCGGC 30 GGCTCCAACATGGCTACTCAAGGTGCTATGCCAGCTTTTGCTTCTGCTTTTC-\P>.CGTCGTGCAGGT GGTGTTCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTT GCGCAGCCCTCTGGCGGCTCTGGCGGCTCTCAGAGCTTCCTGCTOJKGTCTTTAGAGCAAGTGAGA AAGATCCAGGGCGATGGvCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCACCCC GAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGC 35 CAGGCCCTGCAGCTGGCAGGCTGCTTGAGCC.^CTCCATAGCGGCCTTTTCCTCTACCAGGGGCTC CTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTC GCCGACTTTGCCACCACCATCTGGCAGCAGATGGP<AGAACTGGG.-J\TGGCCCCTGCCCTGCAGCCC SEQ ID MO :3 05 40 pM0M3 9910.seq 45 50 55

GCTACTCA^.GGTGCTATGCCAGCTTTTGCTTCTGCTTTTCAACGTCGTGCAGGTGGTGTTCTGGTT GCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCCTCT GGCGGCTCTGGCGGCTCTCAGAGCTTCCTGCTCAAGTCTTTAGAGCAAGTGAGAAAGATCCAGGGv- GATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCACCCCGAGGAGCTGGTG CTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCCCTGCAG CTGGCAGGCTGCTTGAGCCA^.CTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAGGCCCTG GAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGACTTTGCC

ACCACCATCTGGCAGCAGATGGAAG.^TGGG^TGGCCCCTGCCCTGCAGCCCTACGTAGAGGGC GGTGGAGGCTCCCCGGGTG^CCGTCTGGTCC.^ATCTCTACTATC^.CCCGTCTCCTCCGTCTAJ^ GAATCTCATPu^TCTCCAA^.CATGGCCGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTG GCACAGCGCTGGATGGAGCGGCTCAP.GACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGC GTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTC GTCCAGACCA--.CATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGG ATCACTCGCCAGA.^CTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCA.ACCCTGGGC GGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAG

GACTGCTCCTTCC^CACAGCCCCATCTCCTCCGACTTCGCTGTCA-^ATCCGTGAGCTGTCTGAC TACCTGCTTC.^GATTACCCAGTCACCGTGGCCTCC.^CCTGCAG SEQ ：D MO : 3 0o 60 pMOM35727.seq

GCCGACGAGGAGCTGTGCGGTGGCCTCTGGv^GGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC ^GACTGTCGCTGGGTCCA.^GATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTCTC 65 accaaatgtgcctttc.'gcccccccccagctgtcttcgcttcgtccagaccaacatctcccgcctc CTGCAGGAGACCTCCGAGCAGCTGGTGGvCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGG TGCCTGGAGCTGCAGTGTCAGCCCGACTCCTC.\ACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGG；v GGTGGATCCGGAGGTGG*\ACCCAGGACTGCTCCTTCC.^CACAGCCCCATCTCCTCCGACTTCOCT GTC.^^TCCGTGAGCTGTCTGACTACCTCCTTC^GATTACCCAGTCACCGTGGCCTCC.^CCTG 70 CAGTACGTAGAGGCCGGTGGAGGCTCCCCGGGTG^CCGTCTGGTCC.\ATCrCTACTATC^CCCG TCTCCTCCGTCTA*\AG,\ATCTCATA.^TCTCCA；vACATGGCCGACGAGGAGCTCTGCGGGGGCCTC TGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC^.GACTGTCGCTGGGTCC.^AGATGC^ GGCTTGCTGGAGCGCGTG^CACGGAGATACACTTTGTCACC.^AATGTGCCTTTCAGCCCCCCCCC AGCTGTCTTCGCTTCGTCCAGACC.^ACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTG 75 GCGCTG.-\^.GCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGAC -184-

O:\92\92747.DOC 200413407 TCCTC.^ACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCACCCAGGAC TGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTC.\AAATCCGTGAGCTGTCTGACTAC CTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAG SEQ ID ：307 OM0M32163.seq GCTGATG.nAGAACTGTGTGGTGGTCTGTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC AAGACTCTCGCTGGGTCCAAGATGCAAGGCTTGCTCGAGCGCGTGAACACGGAGATACACTTTGT'C ACCAAATGT'GCCT'TTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTC 10 CTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGG TGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGA GGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCC*\ACACAGCCCC ATCTCCTCCGACTTCGCTGTCAAA.\TCGGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTC ACCGTGGCCTCCAACCTGCAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTG^CCGTCTGGTCCA 15 ATCTCTACTATCAACCCGTCTCCTCCGTCT^^GAATCTCAT.\AATCTCC^ACATGGCTACCCAG GACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTCAGCTGTCTGAC TACCTGCTTC.\AAATTACCCAGTCACCGTGGCCTCC.\ACCTGCAGGACGAGGAGCTCTGCGGGGGC CTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATG CAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTrTCAGCCCCCC 20 CCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTG GTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCC GACTCCTCAACCCTG SEQ ID NO :3 03 25 pMCN3 2195.seq GCTGATG^.GAACTGTGTGGTGGTCTGTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC AAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTC ACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC.-ACATCTCCCGCCTC 30 CTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGA-\GCCCTGGATCACTCGCCAGAACTTCTCCCGG TGCCTGGAGCTGCAGTGTCAGCCCGACTCCTC^J\CCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGA GGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCC ATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCA.^GATTACCCAGTC ACCGTGGCCTCCAACCTGCAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGGTGGTTCTGGCGGC 35 GGCTCCAACATGGCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTCT TTAGAGCAAGTGAGAAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTAC AAGCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTG AGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTC CTCTACCAGGGGCTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACA 40 CTGCAGCTGGACGTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGAACTGGG^ATGGCC CCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGA GGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTT GCGCAGCCCTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCA,.\TCTCTACTATC AACCCGTCTCCTCCGTCTPlAAGAATCTCATAAATCTCCAAACATGGCTGATGAAGAACTGTGTGGT 45 GGTCTGTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAG ATGC^GGCTTGCTGGAGCGCGTG^CACGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCC CCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAG CTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAG CCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTCA 50 GGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCTGTC A^^ATCCGTGAGCTGTCTGACTACCTGCTTC^GATTACCCAGTCACCGTGGCCTCC^CCTGCAG SEQ ID MO：309 OMCM32I36.seq 55 .

GCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCA^.GTCTTTAGAGCA^.GTG AGAA^.GATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTAC^.GCTGTGCCAC CCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCC AGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCA.nCTCCATAGCGGCCTTTTCCTCTACCAGGGG 60 CTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGAC GTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCTGCCCTGCAG CCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGGAGGAGGGGTCCTGGTT gctagccatctgcagagcttcctggaggtgtcgtaccocgttctacgccaccttgcgcagccctac

GTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACT.VTCAACCCGTCTCCT 65 CCGTCT，入'GAATCTCATAAATCTCCAAACATGGCTGATGAAGAACTGTGTGGTGGTCTGTGGCGG

CTGGTCCr：GGCACAGCGCTGGATGGAGCGGCTCA.\GACTGTCGCTGGGTCCAAGATGCAAGGCTTG CTGGAGCGCGTGAACP,CGGAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGT CTTCGCTTCGTCCAGACC^\CATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTG AAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCA 70 accctggccggtgggtcaggaggtgcgtcaggaggtggatccggaggtggctcagggggaggtagt

GGTACCCAGGACTGCTCCTTCCA.^CACAGCCCCATCTCCTCCGACTTCGCTGTC.\.^AATCCGTCAG CTGTCTGACTACCTGCTTC.\AGATTACCCAGTCACCGTGGCCTCC.\ACCTGCAGTACGTAGAGGGC GGTGGAGGCTCCCCGGGTG.\ACCGTCTGGTCC.\ATCTCTACTATCAACCCGTCTCCTCCGTCT.\AA GAATCT 二VTAAATCTCCAAACATGGCTACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCC 75 GACTTCGCTGTCA.^^TCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCC -185-

O:\92\92747.DOC 200413407

ATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTC^GATTACCCAGTC ACCGTGGCCTCCAACCTGCAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGGTGGTTCTGGCGGC GGCTCCAACATGGCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTCT _ TTAGAGCAAGTGAGAAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACTA.^C 5 AAGCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTG AGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCC^CTCCATAGCGGCCTTTTC CTCTACCAGGGGCTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACA ctgcagctggacgtcgccgacttioccaccaccatctggcagcagatggaagaactgggaatggcc cctgccctgcagcccacccagggtgccatgccggccttcgcctctgctttccagcgccgggcagga 10 GGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCOTTCTACGCCACCTT GCGCAGCCG SEQ ID NO：296 PMON32277.seq 15 GCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTC.\AGTCTTTAGAGCAAGTG AGAAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCAC CCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCC AGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCC^ACTCCATAGCGGCCTTTTCCTCTACCAGGGG CTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGAC 20 GTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAG.^ACTGGGAATGGCCCCTGCCCTGCAG CCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTT GCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCCTAC GTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCT CCGTCTAAAGAATCTCAT.\^J\TCTCCAAACATGGCTGATGAAGAACTGTGTGGTGGTCTGTGGCGG 25 CTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCC^.GATGCAAGGCTTG CTGGAGCGCGTG.\ACACGGAGATACACTTTGTCACCAAATCTGCCTTTCAGCCCCCCCCCAGCTGT CTTCGCTTCGTCCAGACC-^CATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTG AAGCCCTGGATCACTCGCCAG^ACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCA ACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGT 3〇 GGTACCCAGGACTCCTCCTTCC.^CACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGCGAG CTGTCTGACTACCTGCTTCA.\GATTACCCAGTCACCGTGGCCTCCAACCTGCAG S^Q ID NO :2 97 PMOW32273.seq 35 GCTGATG^G^CTGTGTGGTGGTCTGTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC A.^GACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTC ACCAAATGTGCCTTTCAGCCCCCCCCCAGCTCTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTC CTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGG 40 TGCCTAGAGCTGCAGTCTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGA GGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCCAACACAGCCCC ATCTCCTCCGACTTCGCTGTCJiJ^AATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTC ACCGTGGCCTCCAACCTGCAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGGTGGTTGTGvGCGGC GGCTCC*\ACATGGCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTC.\AGTCT 45 TTAGAGC^GTGAGAAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGA.AGCTGTGTGCCACT^AC AAGCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTG AGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCC^CTCCATAGCGGCCTTTTC CTCTACCAGGGGCTCCTGCAGGCCCTGGP.J\GGGATATCCCCCGAGTTGGGTCCCACCTTGGACACA CTGCAGCTGGACGTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGG^.G^CTGGGP.ATGGCC 50 CCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGA GGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTT GCGCAGCCG S5Q ID N〇：293 _ pMCM32279.seq

GCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTCTTTAGAGC^GTG AGA^JkGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGCCAC CCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCrTGAGCTCCTGCCCC AGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCC^nCTCCATAGCGGCCTTTTCCTCTACCAGGGG 60 CTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGAC GTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCTGCCCTGCAG CCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTT GCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCCTAC GTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCC^TCTCTACTATC^CCCGTCTCCT 65 CCGTCTAAAGAATCTCATAAATCTCCAAACATGGCAGATGAAGAACTGTGTGGGGGCCT'GTGGCGG CTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC.^.GACTGTCGCTGGGTCCAAGATGCAAGGCTTG CTCGAGCGCGTGAACACGGAGATACACTTTGTCACCr\P«J\TGTGCCTTTCAGCCCCCCCCCAGCTCT CTTCGCTTCGTCCAGACC.^CATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTG .\AGCCCTGGATCACTCGCCAG^CTTCTCCCGGTGCCTGGAGCTGCAGTCTCAGCCCGACTCCTCA 70 accctcggcogtgggtcaggaggtgggtcaggaggtggatccggaggtggctcagggggaggtagt GGTACTCACGACTGTTCTTTTC.\ACACAGCCCCATCTCCTCCGACTTCGCTGTr^AATCCG^GAG CTGTCTGACTACCTGCTTC.-^GATTACCCAGTCACCGTGGCCTCC^CCTGCAG SEQ ID MO : 2 9 '3 75 pMOM3579〇.seq -186-

O:\92\92747.DOC 200413407 GCCACTCAGGACTCCTCTTTTCAACACAGCCCCATCTCCTCCGACTTCGCTGTC^^ATCCGTGAG CTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTC TGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC.\AGACTGTCGCTGGG 5 TCCAAGATGCAAGGCTTGCTGGAGCGCGTG^CACGGAGATACACTTTGTCACCA.\ATCTGCCTTT CAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCC GAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAG TGTCAGCCCGACTCCTC.AACCCTGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGGTGGTTCTGGC GGCGGCTCC^CATGGCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAG 10 TCTTTAGAGCAAGTGAGAAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACT A^.CAAGCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCC CTGAGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCa\ACTCCATAGCGGCCTT TTCCTCTACCAGGGGCTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGAC ACACTGCAGCTGGACGTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGPu^G.^CTGGGAATG 15 GCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCA GGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCAC CTTGCGCAGCCG SSQ ID NO:300 PMON35791.seq 20 GCCACTCAGGACTGTTCTTTTCAACACAGCCCCATCTCCTCCGACTTCGCTGTCA^AATCCGTGAG CTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCAACCTGCAGGACGAGGAGCTC TGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC-^AGACTGTCGCTGGG TCCAAGATGCAAGGCTTGCTGGAGCGCGTG^-ACACGGAGATACACTTTGTCACC.^AATGTGCCTTT 25 CAGCCCCCCCCCAGCTCTCTTCGCTTCGTCC^GACCAACATCTCCCGCCTCCTGCAGGAGACCTCC GAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAG TCTCAGCCCGACTCCTCAACCCTGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGGTGGTTCTGGC GGCGGCTCCAACATGGCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTC^G TCTTTAGAGCAAGTGAGAAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACC 30 TACAAGCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCC CTGAGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCA.-.CTCCATAGCGGCCTT TTCCTCTACCAGGGGCTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGAC ACACTGCAGCTGGACGTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGAACTGGGAATG GCCCCTGCCCTGCAGCCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCA 35 GGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCAC CTTGCGCAGCCG SEQ ID MO :301 pMON35792.seq 40 GCCACTCAGGACTGTTCTTTTC.^CACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAG CTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCCA.^CCTGCAGGACGAGGAGCTC TGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGG TCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACT'TTGTCACCAAATGTGCCTTT _ CAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCC 45 GAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAG TACGTAGAGGGCGGTGGAGGCTCCCCGGGTGGTGGTTCTGGCGGCGGCTCCPl.\CATGGCTACACCA TTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTCTTTAGAGCAAGTGAGAAAGATC CAGGGCGATGGCGCAGCGCTCCAGGAGx\AGCTGTGTGCCACTAACAAGCTGTGCCACCCCGAGGAG CTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCCAGCCAGGCC 50 CTGCAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGGGCTCCTGCAG GCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGACGTCGCCGAC TTTGCCACCACCATCTGGCAGCAGATGGP-AGAACTGGGAATGGCCCCTGCCCTGCAGCCCACCCAG GGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTGGTTGCTAGCCAT CTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCG SEQ ID 55 MO:302 pMON39905.〇eq GCCACTCAGGACTGTTCTTTTC.\ACACAGCCCCATCTCCTCCGACTTCGCTGTC.-A^^TCCGTGAG 60 CTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCC.^CCTGCAGGACGAGGAGCTC TGCGGGGGGCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGG TCCAJ\GATGC.nAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTvCACCA.^ATGTGCCTTT CAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC^CATCTCCCGCCTCCTGCAGGAGACCTCC _ GAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGA*\CTTCTCC.CGGTGCCTGGAGCTGCAG 65 TCTCAGCCCGACTCCTC^CCCTGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGGTGGTTCTGGC GGCGGCTCCAA.CATGGCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTC^G TCTTTAGAGC^GTGAGPu^AGATCCAGGGCGATGGCGCAGCGCTCCAGGAG^GCTGTGTGCCACC TAC^GCTGTGCCACCCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCC CTGAGCTCCTGCCCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCC.\ACTCCATAGCGGCCTT 70 TTCCTCTACCAGGGGCTCCTGCAGGCCCTGG^GGGATATCCCCCGAGTTGGGTCCCACCTTGGAC ACACTGCAGvCTGGACGTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGA.^CTGGG*\ATG GCCCCTGCCCTGvCAGCCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCA GGAGGGGTCCTGGTTGCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCAC CTTGCGCAGCCG SEQ ID NO:303 75 -187-

O:\92\92747.DOC 200413407 TCC^CCTGCAGGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATG GAGCGGCTC.\AGACTGTCGCTGGGTCC*\AGATGC.\AGGCTTGCTGGAGCGCGTGAACACGGAGATA CACTTTGTCACC.^AATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATC TCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAJ\C 5 TTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTG SZQ I〇 NO :310 PMON32137.seq

GCTACACCATTGGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTC^AGTCTTTAGAGC.\AGTG 10 AGAAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTAC^GCTGTGCCAC CCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGCCCC AGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAGGGG CTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTGGAC GTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGAACTGGGPuATGGCCCCTGCCCTGCAG 15 CCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGG^GGGGTCCTGGTT GCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCCTAC GTAGAGGGCGGTGGAGGCTCCCCGGGTG^CCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCT CCGTCTAAAGAATCTCATAAATCTCCAAACA.I'GGCTGATGAAGAACTGTGTGGTGGTCTGTGGCGG CTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCC^AGATGC.^AGGCTTG 20 CTGGAGCGCGTGAACACGGAGATACACTTTGTCACC.^AATGTGCCTTTCAGCCCCCCCCCAGCTGT CTTCGCTTCGTCCAGACCAACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTG AAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCA ACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGT GGTACCCAGGACTGCTCCTTCC.^CACAGCCCCATCTCCTCCGACTTCGCTGTCAA.^ATCCGTGAG 25 CTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCC^JVCCTGCAGTACGTAGAGGGC GGTGGAGGCTCCCCGGGTG*^ACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAA GAATCTCATAA.ATCTCCAAACATGGCTGATGAAGPu\CTGTGTGGTGGTCTGTGGCGGCTGGTCCTG GCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGC GTGAACACGGAGATACACTTTGTCACCA.\ATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTC 30 GTCCAGACC^CATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTG^GCCCTGG ATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCA^.CCCTGGGC GGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAG GACTGCTCCTTCC^CACAGCCCCATCTCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGAC TACCTGCTTC.^GATTACCCAGTCACCGTGGCCTCCAACCTGCAG SEQ ID MO · 311 35 ' PMCN3220S.seq

GCTAACTGCTCTATAATGATCGATGAAATTATACATCACTTAAAGAGACCACCTGCACCTTTGCTG GACCCGAACAACCTCAATGACGAAGACGTCTCTATCCTGATGGACCGAAACCTTCGACTTCCAAAC 40 CTGGAGAGCTTCGTAAGGGCTGTCAAGAACTTAGAAAATGCATCAGGTATTGAGGCAi.TTCTTCGT AATCTCCAACCATGTCTGCCCTCTGCCACGGCCQCACCCTCTCGACATCCAATCATCATC.^.GGCA GGTGACTGGCiAGA^.TTCCGGGAAAAACTGACGTTCTATCTGGTTACCCTTGAGCA.\GCGCAGGAA CAACAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGA.^CCGTCTGGTCC^TCTCTACTATC^C CCGTCTCCTCCGTCTAA.^GAATCTCAT.\AATCTCCAAACATGGCTGATG^GAACTGTGTGGTGGT 45 CTGTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCAAGACTGTCGCTGGGTCC^-AGATG C*^AGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAA.\TGTGCCTTTCAGCCCCCC CCCAGCTGTCTTCGCTTCGTCCAGACCA.\CATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTG GTGGCGCTGAAGCCCTGGATCACTCGCCAGA.^CTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCC GACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTCAGGG 50 GGAGGTAGTGGTACCCAGGACTGCTCCTTCC^CACAGCCCCATCTCCTCCGACTTCGCTGTC^A ATCCGTGAGCTGTCTGACTACCTGCTTC^GATTACCCAGTCACCGTGGCCTCC.\ACCTGCAGTAC GTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCC^TCTCTACTATC^CCCGTCTCCT CCGTCTAAAGAA.TCTCATAAATCTCCAAACATGGCT'GATGAAGAACTGTGT'GGTGGTCTGTGGCGG CTGGTCCTGGCACAGCGCTGGATGGAGCGGCTCA.^GACTGTCGCTGGGTCC>AGATGCAAGGCTTG 55 CTGGAGCGCGTG^CACGGAGATACACTTTGTCACC.^TGTGCCTTTCAGCCCCCCCCCAGCTGT CTTCGCTTCGTCCAGACC.^ACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTG ^GCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCA ACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGAGGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGT GGTACCCAGGACTGCTCC7TCC.-.ACACAGCCCCA7CTCCTCCGACTTCGCTGTC^\ATCCGTGAG 60 CTGTCTGACTACCTGCTTC^.GATTACCCAGTCACCGTGGCCTCC.\ACCTGCAG SEQ ID MO：312 · PMON32207.seq ^

65 GCTGATG^G.^CTGTGTGGTGGTCTGTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC ^GACTGTCCCTGGGTCC^GATGCAAGGCTTGCTGGAGCGCGTG^CACGGAGATACACTTTGTC ACCX\.ATGTGvCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC^.CATCTCCCGCCTC CTGCAGGAOACCTCCGAGCAGCTGGTGGCGCTG^.GCCCTGGATCACTCGCCAG^CTTCTCCCGG

tgcctggagctgcagtctcagcccgactcctc.\accctgggcggtgggtcaggaggtgggtcagga 70 GGTGGATCCGGAGGTOGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCC^CACAGrCCC ATCTCCTCCGACTTCGCTGTC^^.TCCGTGAGCTGTGTGACTACCTGCTTC^GATTACCCAGTC ACCGTGGCCTCC.^CCTGCAGTACGTAGAGGGCGGTGGAGvClCTCCCCGGGTGGTGGTTCTGGCGGC GGCTCC^CATGCCTGATC^G.^ACTGTGTGGTGGTCTGTGGCGGCTGGTCCTGGCACAGCGCTGG ATGGAGCGGCTC.^GACTGTCGCTGGGTCC.^AGATGCA^GGCTTGCTGGAGCGCGTGAACACGGAG 75 ATACACTT^GTCACC^^ATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC.-^C

O:\92\92747.DOC 188- 200413407 ATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAG AACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGA GGTGGGTCAGGAGGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTC — CPu\CACAGCCCCATCTCCTCCGACTTCGCTGTCA.\AATCCGTGAGCTGTCTGACTACCTGCTTCAJ\ ^ gattacccagtcaccgtggcctccaacctgcagtacgtagagggcggtggaggctccccgggtgaa CCGTCTGGTCCMTCTCTACTATC\ACCCGTCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAAC ATGGCTACACCATTAGGCCCTGCCAGCTCCCTGCCCCAGAGCTTCCTGCTCAAGTGCTTAGAGCAA GTGAGGAAGATCCAGGGCGATGGCGCAGCGCTCCAGGAGAAGCTGTGTGCCACCTACAAGCTGTGC CACCCCGAGGAGCTGGTGCTGCTCGGACACTCTCTGGGCATCCCCTGGGCTCCCCTGAGCTCCTGC 10 CCCAGCCAGGCCCTGCAGCTGGCAGGCTGCTTGAGCCAACTCCATAGCGGCCTTTTCCTCTACCAG GGGCTCCTGCAGGCCCTGGAAGGGATATCCCCCGAGTTGGGTCCCACCTTGGACACACTGCAGCTG GACGTCGCCGACTTTGCCACCACCATCTGGCAGCAGATGGAAGAACTGGGAATGGCCCCTGCCCTG CAGCCCACCCAGGGTGCCATGCCGGCCTTCGCCTCTGCTTTCCAGCGCCGGGCAGGAGGGGTCCTG GTTGCTAGCCATCTGCAGAGCTTCCTGGAGGTGTCGTACCGCGTTCTACGCCACCTTGCGCAGCCC 15 TGATAAGGATCCGAATTCGGCAGC 3EQ ID NO :313 pMON3 57 2 3.seq

GCCGACGAGGAGCTGTGCGGTGGCCTCTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC 20 AAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTC ACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC^CATCTCCCGCCTC CTGCAGGAGACCTCCGAGCAGCTGGTGGCGCT'GAAGCCCTGGATCACTCGCCAGAACTTCTCCCGG TGCCTGGAGCTGCAGTGTCAGCCCGACTCCTCAACCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGA GGTGGATCCGGAGGTGGAACCCAGGACTGCTCCTTCCAACACAGCCCCATCTCCTCCGACTTCGCT 25 GTCAAAATCCGTGAGCTGTCTGACTACCTGCTTC.^AGATTACCCAGTCACCGTGGCCTCCAACCTG CAGTACGTAGAGGGCGGTGGAGGCTCCCCGGGTGAACCGTCTGGTCC^TCTCTACTATC^CCCG TCTCCTCCGTCTAAAGAATCTCATAAATCTCCAAACATGGCTAACTGCTCTATi^VTGATCGATGAA ATTATACATCACTTAAAGAGACCACCTA^.CCCTTTGCTGGACCCGAACAACCTCP^ATTCTGAAGAC ^ ATGGATATCCTGATGGAACGAAACCTTCG^CTCCAAACCTGCTCGCATTCGTAAGGGCTGTCAAG

30 CACTTAGAAAATGCATCAGGTATTGAGGCAATTCTTCGTAATCTCCAACCATGTCTGCCCTCTGCC ACGGCCGCACCCTCTCGACATCCAATCATCATCAAGGCAGGTGACTGGCAAGAATTCCGGGAAAAA CTGACGTTCTATCTGGTTACCCTTGAGCAAGCGCAGGAACAACAGTACGTAGAGGGCGGTGGAC-GC TCCCCGGGTG^ACCGTCTGGTCCAATCTCTACTATCAACCCGTCTCCTCCGTCTAAAG^TCTCAT AAATCTCCAAACATGGCCGACGAGGAGCTCTGCGGGGGCCTCTGGCGGCTGGTCCTGGCACAGCGC 35 TGGATGGAGCGGCTCAAGACTGTCGCTGGGTCCA.^GATGCA-^GGCTTGCTGGAGCGCGTGAACACG GAGATACACTTTGTCACCAAATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC AACATCTCCCGCCTCCTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGC CAGAACTTCTCCCGGTGCCTGGAGCTGCAGTGTCAGCCCGACTCCTC^CCCTGGGCGGTGGGTCA GGAGGTGGGTCAGGAGGTGCATCCGGAGGTGGCACCCAGGACTGCTCCTTCCAACACAGCCCCATC 40 TCCTCCGACTTCGCTGTCAAAATCCGTGAGCTGTCTGACTACCTGCTTCAAGATTACCCAGTCACC GTGGCCTCCAACCTGCAG SEQ ID NO :314 PMON32133. sea 45 *

GCTGATGAAGAACTGTGTGGTGGTCTGTGGCGGCTGGTCCTGGCACAGCGCTGGATGGAGCGGCTC AAGACTGTCGCTGGGTCCAAGATGCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTC ACCP>-AATGTGCCTTTCAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACCAACATCTCCCGCCTC CTGCAGGAGACCTCCGAGCAGCTGGTGGCGCTG^AGCCCTGGATCACTCGCCAG.^ACTTCTCCCGG 50 TGCCTGGAGCTGCAGTGTCAGCCCGACVCCTC^CCCTGGGCGGTGGGTCAGGAGGTGGGTCAGGA GGTGGATCCGGAGGTGGCTCAGGGGGAGGTAGTGGTACCCAGGACTGCTCCTTCC.^CACAGCCCC ATCTCCTCCGACTTCGCTGTCA^^TCCGTGAGCTGTCTGACTACCTGCTTC^GATTACCCAGTC ACCGTGGCCTCCAACCTGCAGGAATTCAAGCTTGAGCCCAGAGGGCCCACAATCAAGCCCTGTCCT CCATGCAAA.TGCCCAGCACCTAACCTCT'TGGGTGGACCATCCGTCTT'CATCTTCCCTCCAAAGrVTC 55 ^GGATGTACTCATGATCTCCCTGAGCCCCATAGTCACATGTGTGGTGGTGGATGTGAGCGAGGAT GACCCAGATGTCCAGATCAGCTGGTTTGTGA.^C.-ACGTGG^GTACACACAGCTCAGACAC^J\CC CATAGAGAGGATTAC.\ACAGTACTCTCCGGGCGGTCAGTGCCCTCCCCATCCAGCACCAGGACTGG ATGAGTGGCAAGGA.GT'TCAAATGCAAGGTCAACAACAJ^AGACCTCCCAGCGCCCATCGAGAGAACC ATCTC.^AACCCA.^GGGTCAGT^.GAGCTCCACAGGTATATGTCTTGCCTCCACCAG^G^*AGAG 60 ATGACT.^G.\.\ACAGGTCACTCTGACCTGCr\TGGTCACAGACTTCATGCCTGAAGACATTTACGTG GAGTGGACCAACAACGGGAAAACAGAGCTAAACTACAAGAACACTGAACCAGTCCTGGACTCTGAT GGTTCTTACTTCATGTACAGCAAGCTGAGAGTGGP'-^u^AGAAGAACTGGGTGGA.^.G.-^ATAGCTAC TCCTGTTCAGTGGTCCACGACGGTCTGCAC^TCACCACACGACTAAGAGCTTCTCCCGGACTCCG GGTAAA SEQ IS NO：3 i5 65 pMOM3：iR4.seq

GCCACCCAGGACTGCTCCTTTC^CACAGCCCCATCTCCTCCGACTTCGCTGTC^^.TCCGTGAG

CTGTCTGACTACCTGCTTCAAGATTACCCAGTCACCGTGGCCTCC^CCTGCAGGACGAGGAGCTC

70 TGCCGGGGCCTCTGOCGGCTGGTCCTGGCACAGCGCTGGnTGGAGCGGCTC^nGACTGTCGCTGGG TCCAAGATCCAAGGCTTGCTGGAGCGCGTGAACACGGAGATACACTTTGTCACCAAATGTGCCTTT rAGCCCCCCCCCAGCTGTCTTCGCTTCGTCCAGACC.^ACATCTCCCGCCTCCTGCAGGAGACCTCC OAGCAGCTGGTGGCGCTGAAGCCCTGGATCACTCGCCAGAACTTCTCCCGGTGCCTGGAGCTGCAG TGTCAGCCCGACTCCTC^\CCCTGGAATTC.\AGCTTGAGCCCAGAGGGCCCACAATC^GCCCTGT 75 CCTCCATGC^^ATGCCCAGCACCT.^ACCTCTTGGGTGGACCATCCGTCTTCATCTTCCCTCC.^G

O:\92\92747.DOC 189- 200413407 ATCAAGGATGTACTCATGATCTCCCTGAGCCCCATAGTCACATGTGTGGTGGTGGATGTGAGCGAG GATGACCCAGATGTCCAGATCAGCTGGTTTGTGAACAACGTGGAAGTACACACAGCTCAGACACAA ACCCATAGAGAGGATTACAACAGTACTCTCCGGGCGGTCAGTGCCCTCCCCATCCAGCACCAGGAC TGGATGAGTGGCAAGGAGTTCAAATGCAAGGTCAAC.^ACAAAGACCTCCCAGCGCCCATCGAGAGA 5 ACCATCTCAAAACCCAAAGGGTCAGTAAGAGCTCCACAGGTATATGTCTTGCCTCCACCAGAAGAA GAGATGACTAAGA^J\CAGGTCACTCTGACCTGCATGGTCACAGACTTCATGCCTGAAGACATTTAC GTGGAGTGGACCAACAACGGGAAAACAGAGCTAAACTACAAGAACACTGAACCAGTCCTGGACTCT GATGGTTCTTACTTTCATGTACAGCAAGCTGAGAGTGGAAAAGAAGAACTGGGTGGAAAGAAATAGC TACTCCTGTTCAGTGGTCCACGAGGGTCTGCACAATCACCACACGACTAAGAGCTTCTCCCGGACT 10 CCGGGTAAA SEQ ID NO:316

O:\92\92747.DOC -190- 200413407 TABLE 3 PROTΞΙM SEQUENCES oMCM26458cep 5 ^

SerProAlaProProAlaCysAopLeuArgValLeuSerLysLeuLeuArgAspSerHis ValLeuHisSerArgLeuSerGlnCysProGluValHis ProLeuProThrProValLeu LeuProAiaValAspPheSerLeuGlyGluTrpLysThrGlrLMetGIuGiuThrLysAla GlnAspIleLeuGiyAlaValThrLeuLeuLeuGluGlyValMetAlaAlaArgGlyGln 10 LeuGlyProThrCysLeuSerSerLeuLeuGlyGinLeuSerGlyGlnValArgLeuLeu LeuGlyAlaLeuGInSerLeuLeuGlyThrGlnLeuProProGlnGlyArgThrThrAla HisLysAspProAsnAlallePheLeuSerPheGlnHisLeuLeuArgGlyLysValArg PheLeui^etLeuValGlyGlySerThrLeuCysValArgGluPhe SEQ ID NO:467 15 pMON235 48pep

SerProAlaProProAlaCysAspLeuArgValLeuSerLysLeuLeuArgAspSerHis ValLeuHisSerArgLeuSerGInCysProGluValHisProLeuProThrProValLeu LeuProAlaValAspPheSerLeuGlyGiuTrpLysThrGlrLMetGluGluThrLysAla 20 GlnAspIleLeuGlyAlaValThrLeuLeuLeuduGlyValMetAlaAlaArgGlyGln LeuGlyProThrCysLeuSerSerLeuLeuGlyGlnLeuSerGiyGlnValArgLeuLeu LeuGlyAiaLeuGlnSerLeuLeuGlyThrGlaLeuProProGlnGlyArgThrThrAla HisLysAspProAsnAiallePheLeuSerPheGlnHisLeuLeuArgGlyLysValArg PheLeuMecLeuValGlyGlySerThrLeuCysValArgGluPheGlyGlyAsnMetAla 25 SerProAlaProProAlaCysAspLeuArgValLeuSerLysLeuLeuArgAspSerxHis ValLeuKisSerArgLeuSerGlnCysProGIuValHisProLeuProThrProValLeu LeuProAlaValAspPheSerLeuGiyGluTrpLysThrGlni^etGiuGluThrLysAIa G1 nA s p I i 0 L e u G1 y A1 a Va 1T h r L e u L e u L e uG 1 uG 1 y Va 1 Me t A1 a A1 a Ar gG 1 y G1 n LeuGIyProThrCysLeuSerSerLeuLeuGlyGlnLeuSerGlyGlnValArgLeuLeu 30 LeuGlyAlaLeuGlnSerLeuLeuGIyThrGInGlyArgThrThrAlaHisLysAspPro AsnA丄al； lePheLeuSerPheGlnHisIieuLeuArgGlyLysValArgPheLeuMetLeu ValGiyGlySerThrLeuCysValArg SEQ ID NO：453 OMON23500 35

SerProAlaProProAlaCysAspLeuArgValLeuSerLysLeuLeuArgAspSerHis ValLauHisSerArgLeuSerGlnCy5ProGIuVaiHisProLeuProThrProValLeu LeuProAlaValAspPheSerLeuGiyGluTrpLysThrGlmMetGluGluThrLysAla G1 nAs p 11 e Le uG I y Ai a Va IThr L e uL eu L e uG luG I v Va iMe t A i a A1 gG 1 yG 1 n

40 LeuGiyPrcThrCysLeuSerSerLeuLeuGlyGInLeuSerGIyGlnValArgLeuLeu LeuGlyAiaLeuGinSerLeuLeuGlyThrGlnLeuProProGlnGiyArgThrThrAla HisLysAspProAsnAlaliePheLeuSerPheGlnHisLeuLeuArgGlyLysVaiArg PheLeuMetLeuValGIyGlySerThrLeuCysValArgGluPheGlyAsrJietAlaSer ProAlaProProAlaCysAspLeuArgValLeuSerLysLeuLeuArgAspSerHisVal 45 LeuHisSerArgLeuSerGInCysProGiuValHisProLeuProThrProValLeuLeu ProAlaValAspPheSerLeuGlyGluTrpLysThrGlnMetGiuGluThrLysAlaGln Asp IieLeuGlyAlaValThrLeuLeuLeuGiuGlyValMetAlaAlaArgGlyGinLeu GlyProThrCysLeuSerSerLeuLeuGlyGlnLeuSerGiyGlnValArgLeuLeuLeu G1 y A i a L euG 1 n S er 乙eu LeuG 1 y‘T 1 n乙e u ? r c P r oG i nG 1 yArgThrThr· A1 aH i s 50 LysAsp?rc.AsnAiaIiePheLeuSerPhe<3inHisLeuLeuArgGly.LysValArg?he LeuMeCLeuVa1GIyGiySerThrLeuCysVaIArg SEQ ID MO :469 PMOM2B501 55 SerProA.laProProAlaCysAspLeuArgValLeuSerLysLeuLeuArgAspSerHis Va1Le uHis S e rArgLeuSe rGInCys P roG1uVaIHisProLeuProThrProValLeu LeuProAiaValAspPheSerLeuGlyGluTrpLysThrGlnMetGluGluThrLysAia GI nAs p 11 e L e uG 1 y A1 a Va 1T h r L e u L e u L e uG I uG i y Va i Me t A1 a A1 a Ar gG 1 y GI n LeuGlyPrcThrCysLeuSerSerLeuLeuGlyGInLeuSerGlyGlnValArgLeuLeu 60 LeuGiyAlaLeuGinSeirLeuLeuGlyThirGlnLeuPrOPiroGlnGlyArgThirThrAla HisLysAspProAsnAIallePheLeuSerPheGInHisLeuLeuArgGlyLysValArg PheLeuMetLeuVdlGlyGlySerThrLeuCysValArgGluPheGlyGlyAsnMetAla SerProAlaProProAlaCysAspLeuArgValLeuSerLysLeuLeuArgAspSerHis Va1LeuHis SerArgLeuSerG inCys ProGiuValHisProLeuProThrProValLeu 65 L eu P r 〇 A. 1 a Va 1 As p ? he S e r L euG 1 yG 1 uT r p Ly sThr G1 nMe tGluGluThrLysAla

GinAspIi^LeuGLyAlaValThrLeuLeuLeuGiuGlyValMetAlaAlaArgGlyGln LeuG LyPrcThrCysLeuSerSerLeuLeuGlyGInLeuSerG LyGlnValArgLeuLeu LeuGiyAlaLeuGir.SerLeuLeuGlyThrGlnLeuProProGlaGlyArgThrThrAla Η i 3 L y 3 Λ 3 p P r ο Λ 3 n A1 a I i e ? h e L e u S e r P h e G 1 η H i s L e u L e u A r g G1 y L y 3 V a IΛ r g 70 ?heLuM51LeuVa 1G1 yG iySerThrLeuC'/sVa 1Λrg SEQ ID MO :47 0 PMCN2850：

Ser ProAiaProProAlaCysAspLeuArgValLeuSerLysLeuLeuArgAspSerHis 75 '/a 1 LeuH is SerArgLeuSerG InC'/sProGi u'./a IHisProLeuProThr PiroVai Leu

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LeuProAlaValAspPheSerLeuGlyGlaTrpLysThrGiriMetGIuGluThrLysAla G1 nAs p 11 e L e uG 1 y A 丄 a Va 1 Th r· L e u L e u L e liG 1 uG i y Va iMe t A1 <a A1 j: gG 1 y G1 n LeuGlyProThrCysLeuSerSerLeuLeuGlyGlnLeuSerGlyGlnValArgLeuLeu ^ LeuGly-AlaLeuGlnSerLeuLeuGlyThrG InLeuProProGlnGlyArgThrThrAia 5 HisLysAspProAsnAlallePheLeuSerPheGlnHisLeuLeuArgGlyLysValArg PheLeuMetLeuValGlyGlySerThrLeuCysValArgGluPheGIyGlyAsnGlyGly AsnKetAlaSerProAlaProProAlaCysAspLeuArgValLeuSerLysLeuLeuArg AspSerHisValLeuHisSerArgLeuSerGlnCysProGluValHis ProLeaProThr 10 ThrLysAiaGiriAspIleLeuGlyAlaValThrLeuLeuLeuGluGlyValMetAiaAla ArgGlyGlnLeuGl'/ProThrCysLeuSerSerLeuLeuGlyGlnLeuSerGlyGlnVal ArgLeuLeuLeuGlyAIaLeuGlnSerLeuLeuGlyThrGlnLeuProProGinGlyArg Thrl'hrAiaHisLysAspProAsnAlallePheLeuSerPheGinHisLeuI^uArgGl：/ LysVaiArgPheLeuiMetLeuVaiGlvGlvSerThrLeuCvsValArg SEQ ID MO ： 471 15 - 13182.?ept 20 5 2 o 3

p s p AAGAG -olruannys rae*™I r-i r—I f—f f—ί *λ? V s GAG G G HTG 5 3 ?y u u p r a 1 rga r 1 e e r h 1 aer 1 llttavsaa

oreaau a y oasu p nrly Γ y sr reh 11 丄 1 lrlvlesl 1 lel y h ’ . ；PAC LAG G G s G LT a e 1 e o e .—I rHallr,JLl AI V I p p g p uer p u o s o a y r e o guyl s rsl i hrlryrl 1 h lrrl iay A A G I T T G ? c ?AG τ I p A G G V c H e ---ΪI A A G c I 一 y L G L· ga sno a oa e u PI Π

G

3S n yl r u u uuo 1 u r p esas i yl laeelel Γ aees rlAVAH L G G V SLGLG? V Γ1 sAj; ut acr*guny urnu nut u iny 4 e e 1 r r 11Γ : : ' ! ——· Ϊ L . lmaaag G -ougu r u rereerl e 1 e e i eei ? L A L s A G s G L· s A r- Μ λ V A s G T- n y u 〇 u n rnyVI ryeQ re-一.-Tik,I 1-「-vt r---1 -—ί Ξ •I G G G 0- G T G G G T G -1 s 0 1 s 1 1 0- 0 all : G L s GLG G MLV G Gio ru uraQtai g Γ d rereerl e Ieeieeiarei D G L sal mava- ^ptnsuou sr v‘0re

V- 0 r e yl e 7i 5 e IX 1~ r h I A L L p rlTG L c H GALAAA p G V- u s s Vi- u a a 9 e V- e . ! · L .

nuuoeeun.yryracasuua seer1 h lslelelel ieei AL Γ1 p I p GAG s G SAMAHLLA o naae r 1 ruo rei y e r s ua rs s 1 1，daeerelaihe.le,i PAAG I Tvs L p s IVG ? s H L A

A L n cn user VI c s n r._、v, ,!··/,,.—-l0-.-T-l.e T GMH G L

uoparuasu rslieelye PAAS LALL

3r「J.r lalye ee. A PA? AVG T L L L L A A ? s ? L G

'/T r u u u uaa ero u u alyeeeellhere- uunusuyaraeueoannrn e e s e yell elhlh rll- -.1 e I I :LL GAS Λ p G p ?AG G s G

p n r ryr y s y n r y r uae rur3 3 seel h 1 y i 1 y 1 hei helyAAS s GTGLG GTG TLG p s G L

uuya p urueunorngu ynu i e 11 3 e e e T- e 1- r h 1- r e 11 e AL s rl I L G PTGAL G G L 40 13133 . Pept: Asn Cys Ser 工Met lie Asp Giu He I Le His His Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Giu Asp 45 Val Ser He Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser -?he Vai Arg Ala Val Lys Asn Leu Glu Asp. Aia Ser Gly lie Glu Ala lie Leu Arg Asn Leu Gin Pro Cys，Leu Pro Ser Ala Thr Aia Ala Pro Ser Arg His Pro lie He lie Lys Ala Gly Asp Trp Gin Glu ?he Arg Glu Lvs Leu Thr Phe Tyr Leu Vai Thr Leu Giu 50 Gin Ala Gin Giu Gin 〇Ia Tyr val Giu Gly Gly Giv Gly Ser Pro Gly Glu Pro Ser Gly Pro lie Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Giu Ser His Lys Ser Pro Asn Met Ala Tyr Lys Leu Cys His Pro Giu Glu Leu Val Leu Leu Giy His Ser Leu Gly lie Pro Trp Aia Pro Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin. Leu Aia 55 Gly Cys Leu Ser Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Giy Leu Leu Gin Ala Leu Giu Giy lie Ser Pro Glu Leu Gly Pro Thr Leu A〇p Tar Leu Gin Leu Asp Vai Aia Asp Phe Aia Thr Thr lie Trp Gin Gin Mec Glu Glu Leu Gly Met Aia Pro Aia Leu Gin Pro Thr Gin Gly Ala Met Pro Aia Phe Ala Ser Ala Phe Gin Arg Arg 60 Ala Gly Giy Vai Leu Val Ala Ser Kis Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro Ser Gly Gly Ser Gly Giy Ser GLa Ser Phe Leu Leu Lys Ser Leu Glu Gin Vai Arg Lys Ili Gia Giy Asp Giy Ala. Aia Leu Gin Glu Lys Leu Cys Ala Thr SEQ ID MO：473 65 13184.?ept Asn Cys Ser lie Met He Asp GLu ILe lie His His Leu Lys Arg 70 Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Giu Asp VaI S,三!:· ： le Leu Mec Asp Arg Asn Leu Arg Leu Pro Asn Leu Giu Ser Hi Arrg .二.ia VVii Lys Asn Leu Glu Asn Ala Ser Gi'/ lie Glu Aid Leu Arg Asn Leu Ciin ?r:。Cys Leu ?r。Ser Aia Thr Ala Aia Pro Ser Arg His Pro lie lie lie Lys Ala Giy Asp Trp 75 Gin Giu Phe Arq GLu Lys Leu Thr Phe Tyr Leu Val Thr Leu Giu

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ny rnyyry eru u u 4 .—i.—- h ._ .~~^ .~ly_~_ .·—lyeee.. G GTG G GTG ITLL LNO urpnnyry srrae* >—<es,~~f lI-e,—ty_T*4e1 丄 JCJD G SAG G G s G L T SA? I nyupralr a-asnuQ i ierh laerl i leE G G LTTAVSAAH G L s ayreogu'/ls'/ryr 1 _—ί h *~Jrrl lay.~- 0 ^~- 0 A G τ I PAG Gvc G s G s nyornguynuuore rhl rell eer erl GGPTGALGGLLPSI

n y u 11 G G igrasynr eela rel ylly LKA V A s G L G GT4

casuuauoun eli e ell r el G A A M A H L L A G D' L G yclyersuaoasu .~lea.~ί he>ielriye GMVG ? s H LAPAC L u n p u a a 9 e V- 3 O' V- u lssel lrh i ir*-<e GAALAAAP GHTG L Iruuolurpsoay-aeeiraeesyrl 1 vslgpvlsacpag rynutulnyueun /111 e e all el 01 T'G G G M LVG G L I L G Γ SI e el* PAA s la ~<aa 111

Γ 1 h p GT

oyrunerususs/ 1 h e 1 h el ye y.l 1 lgpsgllchg ruaaerouulruu e e 1 1 xierel aee 1 s LAAP s p L G V s L G y ueo a nnrnu rnu ,—{.--lhdr<—< 1 *-He1xee,—le ggppaggsglsgl yoparuasuuura ί i y e 1 e e 1 LSA L L GL< 13185.Pept

Asn Pro Val Ser Glu Ala 25 Gin Gin Gly Ser Pro 30 Thr Gin Arg Leu Gly 35 Gin Leu Leu Pro Ser 40 lie 20

Cvs Pro Ser Phe Al s. Ala Glu Ala Glu Lys Thr He Pro Arg Glu Gly Val Cys Gly Ser Gly Ser

Ser Ala lie Val lie Pro Phe Gin Pro Glu Leu Trp Thr Ala Val Ser Arg Al<a. His Gin Leu SEQ

Ils Met lie Pro Leu Leu Leu Met Asp Arg Ala Val Leu Arg Asn Ser Arg His Arg Glu Lys Glu Gin Gin Ser Gly Pro Ser.’His Lys Asp Thr Leu Gin Gin Mec Gin Gly Ala Gly Gly V3.1 Ser Tyr Arg Gly Gly Ser Lys lie Gin Thr Tyr Lys Ser Leu Gly Ala Leu Gin Phe Leu Tyr ID NO :475

Asp Asp Arg Lys Leu Pro Leu Tyr lie Ser Gin Glu Met Leu Val Gin Gly Leu lie Leu Gin

Glu Pro Asn Asa Gin lie Thr Vai Ser Pro Leu Glu Pro Val Leu Ser Asp Cys Pro Ala Glv

He Asn Leu Leu Pro lie Phe Glu Thr Asn Asp Leu Ala Ala Arg Phe Gly His Trp Gly Leu lie Asn Arg G i u Cys r i_e Tyr Gly lie Ket Val Gly Phe Ser His Leu Aid Pro Ala Cys Leu

His Leu Leu Asn Leu Lys Leu Gly Asn Ala Ala Met Ala His Leu Leu Ala. Glu Pro Leu Gin

His Asn Pro Ala Pro Ala Val Gly Pro Pro Asp Ala Ser Leu Ala Lys Leu Glu Leu Ser Ala

Leu Asp Asn Ser Ser Gly Thr Gly Ser Glu Phe Pro Ala Gin Gin Ser Gin Leu Ser Gin Leu

Lys Arg Glu Asp Leu Glu Gly lie Ala Thr Asp Trp Leu Glu Ser Pro Pro Pro Leu Gly Ala Thr Ala Leu Phe Gin Ser.Phe Pro Ser Leu Glu Glu Lys Val Leu Ser Cys Leu Kis Glu Giv 13136.Pept ► 5 Asn Pro Vai Ser Glu )〇 Ala Gin Gin GLy Leu 55 Gin Phe Ser Glu Lys 60 Leu Cys His Gly 一 Asp 65 Leu

Cys Pro Ser Phe A13. Aid Glu Ala Giy Gin Arg Leu GI y Gin Leu Leu Pro Ser lie Val 01 v

Ser Ala lie Val lie Pro Phe Gin 1 '/ Pro Arg Glu Giy Val Cys Giy Ser Gly Ser Aid

He Met lie Pro Leu Leu Leu Met Asp Arg Ala Val Leu Arg Asn Ser Arg His Arg Glu Lys GLul Ολη Cjln Ser Gly Gly Thr Gin Giy Ala Gly Gly Vai Ser Tyr Ser Gly Gly Arg Lys He Ala Thr Tyr His Ser Leu Gin Ala Leu Leu Phe Leu Pro Glu Leu Asp Phe Ala ID' NO： 47 6

Asp Asp Arg Lys Leu Pro Leu Tyr Gly Ala Val Arg Ser Gin Lys Gly Gin Tyr Gly Thr

Glu ?ro Asn Asn Gin "lie Thr Val Ser Met Leu VaL Gin Giy Leu lie Leu Gin Prc Thr lie Asn Leu Leu Pro lie Phe Glu Asn Pro Val Leu Ser Asp Cys pro Ala Giy Thr Ue

He Asn Arg Glu Cvs lie Tyr Gly Met: Ala Ala Arg Phe Gly His Trp Gly Leu Leu Trp

His Leu Leu Asn Leu Lys Leu Giy Ala Phe Ser His Leu A JLcL Pro Aia. Cys Leu Asp Gin

His Asn Pro Ala. Pro Ala Val Gly Met Ala His Leu Leu Ala Glu Pro Leu Gin Thr Gin

Leu Asp Asn Ser Ser Gly Thr Gly A13. Ser Leu A1 «3. Lys Leu Giu Leu Ser Al <3. Leli Met

Lys Glu Leu Gly Ala Asp Leu Ser Pro Ala Gin Gin Ser Gin Leu Ser Gin Leu Gin Glu

Arg Asp Glu He Thr Trp Glu Pro A1 <3. ?he Ser Pro Leu Glu Vai Ser Leu Glu Leu Glu 13197 . Pept: 70 ;\sn Cys Ser lie Met lie Asp Glu He ㈠丄5 Hi3 Leu Lys Pro Pro Λία Pro Leu Leu Aso Pro Asn Asn Leu Asn Asp Glu Val Ser Ue Leu Met Asp Arg Asr. Lau Arg Leu Pro Asn Leu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn A^a ^er Glu Ala lie Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala 75 Ala Ala Pro Ser Arg Hls Pro Tie He lie Lys Ala Giy Asp

g puerp roi i hr A A G I TT

O:\92\92747.DOC -193-

Gin Glu Phe Arg Giu Ly〇 Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin Tyr Val Glu Giy Gly Giy Gly Ser Pro Giy Glu Pro Ser Gly Pro lie Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn MeC Ala Met Ala Pro Ala 5 Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gin Arg Ar^ Ala Gly Gly Val Lt5U Val Ala Ser His Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro Ser Gly Gly Ser Giy Gly Ser Gin Ser Phe Leu Leu Lys Ser Leu Glu Gin Vai Arg Lys lie Gin Gly Asp Gly Ala Ala Leu Gin Glu 10 Lys Leu Cys Ala Thr Tyr L'/s Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly Kis Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser Gly Leu Phe Leu Tyr Glrw Gly Leu Leu Gin Ala Leu Glu Gly lie Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu 15 Asp Val Ala Asp Phe Ala Thr Thr He Trp Gin Gin Mec Giu Giu Leu Gly SEQ ID NO :477 13133.Pept 20 o 3 5 3 40 e e LM8 7 r n 4 hi : TGIO p n L s rxD A G Ir aei e o e nyaag e y spy uup Q el tIQ T- -—I 1 lrh-1 _lr'leerE r,0 A 工 V I p Oi G GAAAp GHT G L L T s s oreaaua y 〇 i urpsoa yreQ y reh 11111 r a eesyr 11丄 h 1 r c p s p A A GAG p V L SAC ?AGT 工 p nolruannytulnyueunorn sraellllleeal 丄 lelelrhl apvsgagggmlvgglilgptg u a u 〇 un eeel rrl i 1 1丄 iee 1 lrel ML Μ AAA G G GAHLL A G p L G eoug urgurers u a oasu :: e hei e lrl ye .lapa ‘

rer eerI· p LAL SAG s p s H ： c T1 euplnssnyrua .: lesas i y 1 leel y e ieel ila<va<klggslallglsa suuuraut p p 一 s s Γ ' - .c :.......... 'I r aaallpltgaggsglsglgg gs u oury r y e riey annrn u 111- Θ 1 e el e r n u Π u suuyapuryyryeruuuu y 1--ier—~ 1—lsee.~1 .—fv-ΙΊ 一 _~~lvleeee Γ1 G rl GAArl s G G T G I TLLLLu pnrryrynyrysrraeu esseerl h 11 lel y hel h 1 LAAS s GTG G G s G L T SA? G snoaoalyralrgasnuo i srlrial h laerl i ler H A p A PAV G T A V s AAH G L p s u unu s uyagu yi s'/ryr -rieesevlel lr,--1 Ifayl-丄eie H L L A L L L G A A G G V c G 3 G s enguserytguynuuore isrl y 1 y lsrel leerel iaag c I T GMA L G G L L p s I enuuoeeurlnerusussy 1 s e e r 1丄 h 131 he1 yeyi 1 IAL L p I p GAG p s G L L c H G η n e r 1 r e r o uu，丄 ruu r s s 1 1 haeherer 丄aeel

uodnnerlrerouu rJ-Γ s s 1 1 haehere, G p A A G I ml V s p s p L G V s L G

rsl 1 hplr'Larel y，i 1 yl AA G I T T G p AVAS G L G G T G

A A e〇 hr p ? pa s -—t A A a c 1 e A Μι y af—t V G p u 5e A L uu el LG

g p uerp u ρβ1·σΪΓηΓ3ν-η.ΓΓ-γ1Γυ T.L 45 50 60 13139.Pept Asn Cys Ser Pro Pro Ala Val Ser lie Ser Phe Val He Pro Phe U i Π Pro Giu A L <3. Λ L 3. Arg Phe 65

G l Li A丄己 Ala. Ale. Gin Glu Gin Ala Giy Giu Ser Lys Met Pro Leu Val Val Leu Gin Ser Gly Asp G1v Leu Cys His lie Pro Trp Leu Ala GIy Gin Giy Leu Pro Thr Leu Thr lie Trp Gin Pro SEQ lie Met lie Pro Leu Leu Leu Met Asp Arg Ala Val Leu Arg Asn Ser Arg His Arg Giu Lys Gin Gin Ser Gly Pro Ser His Lys ? π s Aid S θ it Ser His Leu His Leu Ala Leu Leu Lys Ala Ala Leu Pro Glu Glu Ala Pro Leu Cys Leu Ser Leu Gin Ala Asp Thr Leu Gin Gin Met ID NO：479

Asp Giu Asp Pro Arg Asn Lys> Asn Leu Gin Pro lie Leu Thr Tyr Val lie Ser Ser Pro Ala Phe Gin Ser Gin Pro Ser Leu Gin Glu Leu Val Ser Ser Gin Leu Leu Glu Gin Leu Giu GLu lie Asn Leu Leu Pro lie Phe Glu rrU v Asn Gin p l·-! 0 Ser Glu Lys Leu Cys His Giy Asp Leu lie Asn Arg Glu Cys lia Tyr Gly lie Met Arg LeuGly Gin Leu Leu Pro Ser lie Vai Gly

His Leu Leu Asn Leu Lys Leu Gly Asn Ala Arg GLu Gly Vai Cys Gly Ser Gly Ser Ala Met

His Asn Pro Ala Pro Ala Val Giy Pro Thr Aid Val Ser Arg Ala His Gin Leu Pro Asp A L cl

Leu Asp Asn Ser Ser Gly Thr Gly Ser Gin Gly Ser Gly Lys Thr Ser Ai.8. Phe Glu Phe Pro

Lys Giu Leu Gly Aid Asp Leu Ser Pro Giy Gly Tvr Giy lie Tyr Leu Leu Leu Leu Ala Aid

Arg Asp Glu He Thr Trp Glu Pro Pro Alci. Val Arg Ser Gin Lys Gly Gin Tyr Gly Thr Leu 70 13190.?ept 75

Asn Cys Ser lie Mec He Asp Giu I i-a I Le His His Leu Lys Arg Pro Pro 1 a Pro Leu Leu Asp Pro Λ3Π Asn Leu Asn Asp Glu Asp Val Ser lie Leu Mec Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe V31 Arg A La Val Lvs Asa Lou Giu Asn Ala Ser Gly He

O:\92\92747.DOC -194- 200413407

Glu Aia rle Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro lie lie lie Lys Ala Gly Asp Trp

Gin Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu • Gin Ala Gla Glu Gla Gin Tyr Val Glu Gly Gly Gly Gly Ser Pro 5 Gly Gly Gly Ser Gly Gly Gly Ser Asn Met Ala Ser Ala Phe Gin

Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser Phe

Leu Glu Va1 Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro Ser

Gly Gly Ser Gly Gly Ser Gin Ser Phe Leu Leu Lys Ser Leu Glu

Gin Val Arg LyS He Gin Giy Asp Gly Ala Ala Lea Gin Glu Lys 10 Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu

Leu Giy His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys

Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin. Leu His

Ser Gly Leu ?he Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly — lie Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp 15 Val Ala Asp Phe Ala Thr Thr lie Trp Gin Gin Met Glu Giu Leu

Gly Met Ala Pro Ala Leu Gin Pro Thr Gin Giy Ala Met Pro Ala

Phe Ala SEQ ID NO :480 20 13191.Pept

Asn Cys Ser lie Mec lie Asp Glu lie lie His His Leu Lys Arg

Pro Pro Aia Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu 25 Ser Phe Val Arg Aia Val Lys Asn Leu Glu Asn Ala Ser Giy lie

Glu Aia lie Leu Arg Asn Leu Gin Pro Cys Lau Pro Ser Ala Thr

Aia Aia Pro Ser Arg His Pro lie lie lie Lys Ala Giy Asp Trp

Gin Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Vai Thr Leu Glu

Gin Aia Gin Glu Gin Gin Tyr Val Glu Gly Gly Giy Giy Ser Pro 30 Giy Glu Pro Ser Gly Pro lie Ser Thr lie Asn Pro Ser Pro Pro

Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Ser A丄a Phe Gin

Arg Arg Ala Gly Gly Val Leu Vai Ala Ser Kis Leu Gin Ser Phe

Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro Ser

Gly GLy Ser Gly Gly Ser Gin Ser Phe Leu Leu Lys Ser Leu Glu 35 Gin Val Arg Lys lie Gin Gly Asp Gly Ala Ala Leu Gin Giu Lys

Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu

Leu Gly His Ser Leu Gly lie Pro Trp Aia Pro Leu Ser Ser Cys

Pro Ser Gin Aia Leu Gin Leu Ala Giy Cys Leu Ser Gin Leu His

Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Aia Leu Glu Gly 40 lie Ser Pro Glu 乙eu Giy Pro Thr Leu Asp Thr Leu Gin Leu Asp

Val Aia Asp Phe Ala Thr Thr lie Trp Gin Gin Met Glu Glu Leu

Giy Met Ala Pro Aia Leu Gin Pro Thr Gin Gly Ala Met Pro Ala

Ph“ Ala SEQ N〇：481 45 13192.Pept

Asn Cys Ser He Met lie Asp Glu lie lie His His Leu L'/s Arg

Pro ?rc Ala Pro Leu Leu Asp. Pro Asn Asn Leu Asn Asp Glu Asp . 5〇 va1 Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Aia Val Lys Asn Leu Glu Asa Ala Ser Gly lie

Glu Ala lie Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro He lie He Lys Ala Gly Asp Tr?

Gin Glu Phe Arg Glu Lys Leu Thr Phe 'Tyr Leu Val Thr Leu Glu 55 Gin Ala Gin Glu Gin Gin Tyr Val Glu Gly Gly Giy Gly Ser Pro

Giy Glv GL·/ Ser Gly Gly GLy Ser Asn Me;: Aia Tyr Lys Leu Cys

His Pro GLu Glu Leu Val Leu Lau Gly Kis Ser Leu Giy lie Pro

Trp Aia Pro Leu Ser Ser Cys Pro Ser GLn Aia Leu Gin Leu Ala

Giy Cvs Leu Ser Gin Leu His Ser Giy Leu Phe Leu Tyr Gin Gly 60 Leu Leu Gin Ala Leu Glu Giy lie Ser Pro Giu Leu Gly Pro Thr

Leu Asp Thr Leu Gin Leu Asp Vai Aia Asp Phe Ala Thr Thr lie

Trp Gin Gin Met Giu Glu Leu Gly Mec Ala Pro Ala LNeu Gin Pro

Thr Gin Gly Ala Met Pro Ala Phe Aia Ser Ala Phe Gin Arg Arg

Ala Giy Gly Val Leu Val Ala Ser His Leu Gin Ser Phe Leu Glu 65 Val Ser T-/r Arg Val Leu Arg His Leu Ala GLn. Pro Thr Pro Leu

Gly Pro Aia Ser Ser Leu Pro Gin Ser Phe Leu Leu Lys Ser Leu

Giu Gin Val Arg Lys lie Gin Gly Asp Giy Aia Ala Leu Gin Glu

Lys Leu C'/s Ala Thr SEQ ID MO :432 70 L3L33.?epc

Asn C./3 Γ lie Me C Asp Giu i - lie Η i ^ His Leu L/〇 Arcj

Prr〇 Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp 75 Va 1 Ser lie Leu Met: Asp Arg Asn Leu Arg Leu Pro Asn Le\i Glu

O:\92\92747.DOC -195- 200413407 pb 10 5 20

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yapuroueunornguora IISes ^-elelr hirer el G AAL s p L I L G ? T GAL p s G r ryryrsy n ryr uae r s u eeli-h iey 1-f i y 1 herlh h ye s s G T G s L G GT'G T L G ? T L L aoalyoruuuuaaeroua i r 1 a lry eeee 11 h e r e i d-avgd*tllllaaps?la nusuynaraeueoannua y'eL s <—le>--Ihl-hrillelf AA SAP G p pAG G LA u seryet snu ο p a r u aey 1 yl yl 1 e -i 1 e r SI e elhl G 〇 I TGrlMH G LOJAAS LA? G u o0e urn y Γ yratas urQi erl h i hsleleiai iees L p I p G TAG s G s AMAHL s A 3 8 nnerlrouorelyersn>14 s L L haererel a 1 hei 1 1 : AG 工 Tvs p L p s IVGP· SHG GIO s uoureru ssy p u aam on yereYieeyi 1 se’il rrl D L LOJ L τ I s L c H G A LAAA? G I

se1 A L L L G 0 r p u ο o 1 h r lrr ITT G OL p

soayreoguuuu yr'.—t.· xi -—lrr-—leei c PAGTI PAG L L G 25190.?eot 25 30 35 40 45

As η Pro Vai Ser Glu Ala Gin Gin Gly Pro Thr Gin Arg Leu Pro Ser Gin Leu Ser Gin Leu

Cys Pro Ser p^g Ala Aia Glu Ala Gly Thr lie Pro Arg Glu Leu Leu Glu Val Ser Leu G i u

Ser Aia lie Va：l lie Pro ?he Gin Gly Leu Trp Thr Aia Val Gly Glu Lys Leu Cys His Gly lie Pro Leu Arg Leu Ser Arg Glu Ser Asp Gin Gin Gly Ser Pro Gin Leu Leu Pro Ser lie

Met: Leu Met Aia Arg Arg Glu Gin Gly Thr Gin Gly Gly Tyr A丄3· Val Cys Gly Ser Gly Ser

lie Leu Asp Vai Asn His Lys Gin Giy Leu Met Aia Val Arg Ser Arg Ala His Gin Leu SEQ

Asp Glu lie Asp Pro Asn Arg Asn Leu Lys Asa Leu Leu Gin Pro lie Leu Thr Tyr Val Giy Ser Gin Leu Glu Giu Met Pro Leu Val Val Leu Ser Leu Lys lie Gin. Thr Tyr Lys Ser Leu Gly Ala Leu Gin Phe Leu Tyr ID NO:434

Pro lie Phe Giu Asa Asp Leu Aid Alo. Arg Pro lie Asn Arg Glu Cys lie Tyr Gly Mec Vai Gly Phe Ser His Gin Gly Leu lie Leu Gin

His Leu Leu Asn Leu Lys Leu Giy Ala. Ala Met Ala His Leu Ser Asp Cys Pro Ala. Gly

His Asn Pro Ala Pro Ala Val Giy Pro Α3Ό Aia Ser Leu Ala Phe Gly His Trp Gly Leu

Lea Asp Asn Ser Ser Giy Thr Gly Glu Phe Pro Ala Gin Gin Leu Ala Pro Ala Cys Leu

Lys Glu Leu Glv Ala Asp Leu Ser Leu Aia A丄a Phe Ser Pro Leu Ala Glu Pro Leu c_i L π

Arg Asp Glu lie Thr Trp Glu Pro Gly Thr Leu Gin Phe Thr Lys Leu Glu Leu Ser Ala DMON2 5191. Pep 50 60 65 70

Asn ProVal Ser Glu Ala Gin Gin Gly Ser Pro Thr Gin Arg Leu Pro Ser Gin Leu Ser Gin Leu

Cys Pro Ser Phe Aia A i ci Glu Ala GLu L» y 3 •Τ» U ^ » A 4 lie Pro Arg Glu Leu Leu Glu Val Ser Leu Giu

Ser Aia1 Le val lie Pro ? h e Gin Pro Glu Leu Trp Thr Aia Val G 1 y Glu Lys Leu Cys H s

He ProLeu Arg Leu Ser Arg Giu Ser Ser Asp Gin Gin Gly Ser Pro Gin Leu Leu Pro Ser

Met: Leu Med A1 3. Arg Arg Giu Gin Gly His Thr Gin Gly Gly Tyr Ala Val Cvs Gly Ser

Tie Leu Asp Val Asn His Lys Gin Pro Lys Lau Me C Ala Val Arg Ser Arg Ala His Gin Leu SEQ

Asp' Glu As? Pro Arg Asn Lys Asn Leu Gin Pro lie Leu Thr Tyr Val lie Ser Sar Pro Gin Leu Glu Giu Mec Pro Leu Val Vai Leu Ser Leu

Asn Leu 乙eu Pro' lie ?hs Glu Th ^ Asn Asp Leu Ala Aid Arg Pro lie Asn Arg G i u

Lys lie Gin Thr Tyr Lys Ser Leu Giy Aia Leu Gin Phe Leu Tyr ID MO：485 lie Tyr Glv lie Met Val Gly Phe Ser His Gin Giy Leu 丄1 e Leu Gin

His Leu Leu Asn Leu Lys Leu Gly Asn Aia A13. Met Aia His Leu Ser Asp Cys Pro A 1 <3. Giy

His Asn Pro Ala Pro Ala Val Giy Pro Pro Asp Ala Ser Leu Ala Phe Gly His Trp Gly Leu

Leu Asp As n. Ser Ser Giy G L v Ser Glu Phe Pro Λ1 cl Gin Gin Leu A13. Pro Ala Cvs Leu

Li'/S Glu Leu Giy Ala Asp Leu Ser Pro Leu Ala Aid· PheSer Pro Leu Ala GLu Pro Leu Gin

Arg Asp Glu He Thr Trp Glu Pro Pro Giy Thr Leu Gin ?he Thr Lys Leu Glu Leu Ser A13. 75 13 194.?ect Asn Cv〇 -〇er

Le Mec lie Asp Glu lie lie His His Leu Lys Arg

O:\92\92747.DOC -196 - 200413407

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Giu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie

Glu Ala lie Leu Arg Asn Leu Gla Pro Cys Leu Pro Ser Ala Thr 5 Ala Ala Pro Ser Arg His Pro lie lie lie Lys Ala Gly Asp Trp

Gin Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Giu

Gin Ala Gin Glu Gin Gin Tvr Val Glu Gly Gly Gly Gly Ser Pro

Gly Gly Gly Ser Gly Giy Gly Ser Asn Met Ala Met Ala Pro Aia

Leu Gin Pro Thr Gin Gly Ala Met: Pro Ala Phe Ala Ser Ala Phe 10 Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser

Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro

Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser Phe Leu Leu

Lys Ser Leu Giu Gin Val Arg Lys lie Gin Gly Asp Giy Ala Ala

Leu Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Giu 15 Glu Leu Val Leu Leu Gly His Ser Leu Giy ILe Pro Trp Ala Pro

Leu Ser Ser Cys Pro Ser Gin Aia Leu Gin Leu Ala Giy Cys Leu

Ser Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin

Ala Leu Glu Gly lie Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr

Leu Gin Leu Asp Val Ala Asp Phe Aia Thr Thr lie Trp Gin Gin 20 Met Glu Glu Leu Gly SEQ ID MO :48 6 *

13195.Pept 25 Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser lie Leu Met: Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Giy He

Glu Ala 工le Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr 30 Ala Ala Pro Ser Arg His Pro lie lie Iie Lys Ala Gly Asp Trp

Gin Giu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gin A丄a Gin Glu Gin Gin Tyr ϋΐ Glu Gly Gly G!Ly Gly Seur Pro

Gly Glu Pro Ser Giy Pro lie Ser Thr He Asn Pro Ser Pro Pro

Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Met Ala Pro Ala 35 Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Phe

Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser

Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro

Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser Phe Leu Lsu

Lys Ser Leu Glu Gin Val Arg Lys lie Gin Gly Asp Gly Ala Ala 40 Leu Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Giu

Glu Leu Val Leu Leu Giy His Ser Leu Gly lie Pro Trp Ala Pro

Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu

Ser- Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin.

Ala Leu Glu Gly lie Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr 45 Leu Gin Leu Asp Val Ala Asp Phe Ala Thr Thr lie Tro Gin Gin

Met Glu Giu Leu Gly SSQ ID NO :437 "

13196.Peoc 、 50 、

Asn Cys Ser lie Met lie As? Giu lie Ile His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser Iie Leu Mec Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asa Ala Ser Glv Ile 55 Glu Ala lie Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr

Aia Ala Pro Ser Arg His Pro lie lie lie Lys Ala Gly Asp Trp

Gin Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gin Ala Gin Glu Gin Gin Tyr Val Glu Gly Giy Glv Giy Ser Pro

Gly Gly Gly Ser Gly Gly Gly Ser Asn Met Ala Thr Gin Glv Ala 60 Met Pro Ala Phe Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly Val

Leu Val Ala Ser His Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg

Val Leu Arg His Leu Aia Gin Pro Thr Pro Leu Gly Pro Ala Ser

Ser Leu Pro Gin Ser Phe Leu Leu Lys Ser Leu Glu Gin Val Arg

Lys lie Gin Gly Asp Gly Ala Ala Leu Gin Glu Lys Leu Cvs Ala 65 Thr Tyr Lys Leu Cys His Pro Giu Glu Leu Val Leu Leu Gly His

Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gin

Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser Gly Leu

Phe Leu Tyr Gin Giy Leu Leu Gin Aia Leu Glu Gly He Ser Pro

Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala Asp 70 Phe Aia Thr Thr lie Trp Gin Gin Met Glu Giu Leu Glv Met Ala

Pro Ala Leu Gin Pro SEQ ID MO:438 * ' 13197.Pept 75

O:\92\92747.DOC -197- 200413407

Asn Cys Ser lie Met: lie Asp Glu He lie His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Vai Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie 5 Glu Ala 1le Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro lie lie lie Lys Aia Gly Asp Trp

Gin Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gin Ala Gin Glu Gin Gin Tyr Vai Glu Gly Gly Gly Gly Ser Pro

Gly Glu Pro Ser Gly Pro lie Ser Thr lie Asn Pro Ser Pro Pro 10 Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Thr Gin Gly Ala

Met Pro Aia Phe Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly Val

Leu Val Ala Ser His Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg

Val Leu Arg His Leu Ala Gin Pro Thr Pro Leu Gly Pro Ala Ser _ Ser Leu Pro Gin Ser Phe Leu Leu Lys Ser Leu Glu Gin Val Arg 15 Lys lie Gin Gly Asp Gly Ala Ala Leu Gin Glu Lys Leu Cys Aia

Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His

Ser Leu Gly lie Pro Trp Aia Pro Leu Ser Ser Cys P.ro Ser Gin

Ala Leu Gin Lsu Ala Gly Cys Leu Ser Gin Leu His Ser Gly Leu

Phe Leu Tyr Gin Gl./ Leu Leu Gin Ala Leu Glu Gly lie Ser Pro 20 Glu Leu Gly Pro Thr Leu Asp Thr Leu Gla Leu Asp Val Ala Asp

Phe Ala Thr Thr lie Trp Gin Gin Mec Glu Glu Leu Gly Met Ala

Pro Ala Leu Gin Pro SEQ ID M〇：489

25 13153.?ept

Asn Cys Ser lie Met: lie Asp Glu lie lie His His L^u Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser lie Leu Met： Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu 30 Ser Phe Va 1 Arg Ala Val Lys Asn Leu Glu Asn Aia Ser Gly He

Glu Ala lie Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr

Ala Ala ?ro Ser Arg His Pro lie lie lie Lys Ala Glv Asp Trp

Gin Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu ” Gin Ala Gin Glu Gin Gin Tyr Val Glu Giv Gly Gly Gly Ser Pro 35 Gly Gly Gly Ser Gly Gly Gly Ser Asn Met Ala Ser Ala Phe Gin

Arg Arg Ala Gly Giy Val Leu Vai Ala Ser His Leu Gin Ser Phe

Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro Thr

Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser Phe Leu Leu Lys

Ser Leu Glu Gin Val Arg Lys lie Gin Gly Asp Gly Ala Ala Leu 40 Gin Glu Lys Leu Cys Ala Thr Tyr.Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly Kis Ser Leu Giy lie Pro Trp Ala Pro Leu

Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser

Gla Leu His Ser Giy Leu Phe Leu Tyr Gin Giy Leu Leu Gin Ala

Leu Glu Gly lie Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu 45 Gin Leu Asp Vai Ala Asp Phe Aia Thr Thr lie Trp Gin Gin Met

Glu Glu Leu Gly Met Ala Pro Ala Leu Gin Pro Thr Gin Gly Ala

Met Pro Aia Phe Aia SEQ ID ：490

50 13199.Pepc

Asn Cys Ser lie Met lie Asp Glu lie lie His Kis Leu Lys Arg

Pro Pro Aia Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp 55 Val Ser lie Leu Met: Asp Arg Asn Leu Arg Leu Pro Asa Leu Glu

Ser Phe Vai P\rg Ala Val Lys Asa Leu Glu Asn Ala Ser Gly lie

Glu Ala lie Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg Kis Pro He lie lie Lys Ala Gly Asp Trp

Gin Glu Phe Arg Glu Lys Leu Th.r Phe Tyr Leu Val Thr Leu Glu 60 Gin Ala Gin Glu Gin Gin Tyr Val Giu Gly Gly Giy Giy Ser Pro

Gly Glu Pro Ser Gly Pro lie Ser Thr Ile Asn Pro Ser Pro Pro

Ser Lys Glu Ser His Lys Ser Pro Asn Mec Ala Ser Ala Phe Gin

Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser Phe

Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro Thr 65 ?ro Leu Giy Pro Ala Ser Ser Leu Pro Gin Ser Phe Leu Leu Lys

Ser Leu Glu Gin Val Arg Lys :le Gin Gly Asp Gly Aia Ala Leu

Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu

Leu Va1 Leu Leu Gly His Ser Leu G iy lie Pro Trp Ala P-〇 Leu

Ser Ser c./s Pro Ser Gin Λία Leu Gla Leu Aia Gly Cys Leu Ser 70 Gin Leu His Ser Cly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala

Leu GLu Oly lie Ser Pro Glu Leu Giy Pro Thr Leu r\sp Thr Leu

Gla Leu Asp Val Ala Asp Phe Aia Thr Thr lie Trp Gin Gla Met

Glu Glu Leu Gly Mec Ala Pro Ala Leu Gin Pro Thr Gin Gly Ala

Met Pro Ala Phe Ala 3EQ ：D MO :491 75 O:\92\92747.DOC 198- 200413407 31104. Pep

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aoas upn 一 I—lrI—lyesI~ID puerputuosruasuuurau 亡 s i 1 h r 1 eerye e lye 1 e e 1 e e AGI^-TGMLPLSLALLGLSALH2 9 uuyapueoysa3uuauounrn4 e 1 lsel Γ L i 1 ieel lrelhl: 1GAAL Ξ p G HAH L r〕AG p L GTG 〇 ql e o eau u l-iaT-*-r^i!i .~^ lx IVIPD-GGGTAG reaaua s In .—i 1 ί I i s p aagaa lruann.ererannrnurnunu ae>~I，上.—I r—ί r—<y*~^e.~-.~ί，丄e<teel-tefi.~t , :, , ------s G L :.;

V s GAG G I τ I s A G G

s G L G G

plroerouulruuuu s aer h e rel aeeL e 1 A V s D- p s 0* L G V s L G L G tagguneyna:. ei r rilLl slr丄 laylelel 丄e guyl s yryrat ......r丄 *—taYl'ele-™i MAAAGGIGAAAGGVCGSGSAM ugurgueyeutnuynuuorely ereerllllerelleererlal lalsagigimalggllpsivg rnnerusussypu r h 111 h s 1 he「丄 yeyi ise p 0- G G GTAG ? s G L L chgal 31105. Pep 30 Asn Ala Ser Giy lie Glu Ala lie Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu ?he Arg Glu Lys Leu Thr ?he Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin Gly Giy Gly Ser Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 35 Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Giu Asp Val Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Tyr Val Glu Gly Gly Gly Gly Ser Pro Giy Giu Pro Ser Gly Pro lie Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Giu Ser His Lys Ser Pro Asn Met Ala 40 Thr Gin Gly Ala Met: Pro Ala Phe Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser Kis Leu Gin Ser Phe Leu· Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro Ser Gly Gly Ser Giy Giy Ser Gin Ser Phe Leu Leu Lys Ser Leu Giu Gin Val _ Arg Lys He Gin Gly Asp Gly Ala Ala Leu Gin Glu Lys Leu Cys 45 Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Giy lie Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Giy lie Ser Pro Glu Leu Gly Pro Thr Leu^Asp Thr Leu Gin Leu Asp Vai Ala 50 Asp Phe Ala Thr Thr lie Trp Gin Gin Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gin Pro SEQ ID MO :493

31106.Peo 55 ' Ala Pro Ser Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin. Giu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin Giy Gly Gly Ser Asn Cys Ser lie Msc lie Asp Giu lie Iie His His Leu Lys Arg Pro Pro Ala Pro Leu Leu 60 Asp Pro Asn Asn Leu Asn Asp Giu Asp Val Ser lie Leu Mec Asp Arg Asn Leu Arg Leu Pro Asa Leu Giu Ser Phe Val Arg Ala Val Lys Asn Leu Giu Asn Ala Ser Giy lie Glu Ala lie Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Tyr Val Glu Gly Gly ^ Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie Ser Thr lie Asn 65 Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Mec Ala Thr Gin Giy Ala Met Pro Ala Phe Ala Ser Ala Phe Gin Arg Arg Ala Giy Gly Val Leu Val Ala Ser His Leu Gin Ser Phe Leu Glu VaI Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro Ser Gly Gly Ser Gly Giy Ser Gin Ser Phe Leu Leu Lys Ser Leu Glu Gin Val 70 Arg Lys 11^ Gin Gly A^p G1y Ala Ala Leu Gin Glu Lys Leu Cys Ala Thr Tyr Lys Cys His Pro Giu Giu Leu Va 1 Leu Leu Gly His Ser Leu Gly He Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gin Ala Leu GLa Leu Ala Giy Cys Lea Ser Gla Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie Ser 75 Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala

O:\92\92747.DOC 200413407

Asp Phe Ala Thr Thr He Trp Gin Gin Met Glu Glu Leu ς

Ala Pro Ala Leu Gin Pro SEQ ID NO：494 * 5 3 1107. Pep

Ala Gly Asp Trp Gin Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu

Val Thr Leu Glu Gin Aia Gin Glu Gin Gin Gly Gly Gly Ser Asn

Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg Pro 10 Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val·

Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asa Leu Glu Ser

Phe Val Arg Ala Val Lys Asn Leu Giu Asn Ala Ser Gly lie Glu

Ala lie Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala

Ala Pro Ser Arg His Pro lie lie He Lys Tyr Val Glu Gly Gly 15 Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie Ser Thr Iie Asn

Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala

Thr Gin Gly Ala Met Pro Aia Phe Ala Ser Ala Phe Gin Arg Arg

Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser Phe Leu Glu

Val Ser Tyr Arg Val Leu Arg His Leu Aia Gin Pro Ser Gly Gly 20 Ser Giy Gly Ser Gin Ser Phe Leu Leu Lys Ser Leu Glu Gin Val

Arg Lys lie Gla Gly Asp GLy Ala Ala Leu Gin Glu Lys Leu Cys

Aia Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly

His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser

Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser Gly 25 Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie Ser

Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala

Asp Phe Aia Thr Thr lie Trp Gin Gin Met Glu Glu Leu Gly Met

Aia Pro Ala Leu Gla Pro SEQ ID MO :495 30 31108.?ep

Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val Ser lie Leu Met Αερ Arg Asn Leu Arg Leu Pro Asa Leu Glu Ser Phe Val Arg Aia 35 Val Lys Asn Leu Glu Asn Ala Ser Giy lie Glu Ala lie Leu Arg

Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg

His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin

Gin Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Asn Cys 40 Ser 工le Met lie Asp Glu Ils lie His Kis Leu Lys Arg Pro Pro

Ala Pro Leu Tyr Val Giu Giy Gly Gly Gly Ser Pro Giy Glu Pro

Ser Gly Pro lie Ser Thr 工le Asn Pro Ser Pro Pro Ser Lys Giu

Ser His Lys Ser Pro Asn Met Ala Thr Gin Gly Aia Met Pro Ala

Phe Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly Val Leu Val Aia 45 Ser His Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg

His’乙eu Ala Gin Pro Ser Gly Gly Ser Gly Gly Ser Gin Ser Phe Leu Leu Lys Ser Leu Glu Gin Val Arg Lys lie Gin Gly Asp Gly

Ala Ala Leu Gin Giu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His

Pro Giu Glu Lau Val Leu Lei^ Gly His Ser Leu Giy lie Pro Trp 50 Ala Pro Leu Ser Ser Cys Pro Ser Gin Aia Leu Gin Leu Ala Gly

Cys Leu Ser Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu

Leu Glxn Ala Leu Giu Giy lie Ser Pro Glu Leu Gly Pro Thr Leu

Asp Thr Leu Gin Lau Asp Va 1 Ala Asp Phe Aia Thr Thr He Trp

Gin Glr^ Mec Giu Giu Leu Giy Hec Aid Pro Aia Leu Gin Pro SEQ ID MO :496 3 110 9. Pep

Asn Aia Ser Giy lie Glu Ala lie Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Aia Pro Ser Arg His Pro lie lie lie 60 Lys Ala Giy Asp Trp Gla Glu Phe Arg Glu Lys Leu Thr Phe Tyr

Leu Val Thr Leu Glu Gin Ala Gin Giu Gin Gin Giy Gly Gly Ser

Gly Gly 〇 1V Ser Gl'/ Gly Gly Ser Asn Cys Ser lie MeC lie Asp

Glu He lie His His Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp

Pro Asn Asn Leu Asn Asp Glu Asp Val Ser lie Leu Met: Asp Arg 65 Asn Leu Arg Leu Pro Asn Leu Giu Ser Phe Val Arg Ala Val Lys

Asn Leu Glu Tyr Vai Glu Giy Giy Gly Giy Ser Pro Gly Glu Pro

Ser Giy Pro lie Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Giu

Ser Kis Lys Ser Pro Asn Mec Aia Thr Gin Gly Ala Met Pro Ala ph.0 A1 d 3r Aid Phe Gin. Arcj Arg Aid Giy Gly Vd 1 Leu v3.1 a 1 <a. 70 ser Leu Gin Ser Phe Leu Giu Vai Ser Tyr Arg Vai Lau Arg

His Leu Ala GLa Pro Ser Giy GLy Ser Giy Gly Ser Gin Ser Phe

Leu Leu Lys Ser Leu Glu Gin Val Arg Lys lie Gin Gly Asp GLy

Ala Ala Leu Gla Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His

Pro GLu G Lu Leu Val Leu Leu Gly HLs Ser Leu Gly lie Pro Trp 75 Ala Pro Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly

O:\92\92747.DOC -200- 200413407 C'/s Leu Ser Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Giy Lea

Leu Gin Ala Leu Glu Gly lie Ser Pro Glu Leu Gly Pro Thr Leu

Asp Thr Leu Gin Leu Asp Val Ala Asp Phe Ala Thr Thr lie Trp

Gin Gin Met Glu Glu Leu Gly Met: Ala Pro Ala Leu Gin ?ro 5 SEQ ID M〇：497 31110. Pep

Ala Pro Ser Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin 10 Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin

Ala Gin Glu Gin Gin Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly

Gly Ser Asn Cys Ser lie Mec lie Asp Glu lie He His His Leu

Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp

Giu Asp Val Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn 15 Leu Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser

Gly lie Glu Ai-a lie Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser

Ala Thr Ala Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro

Ser Gly Pro lie Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu

Ser His Lys Ser Pro Asa Met Ala Thr Gin Gly Ala Met Pro Ala 20 Phe Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala

Ser His Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg

His Leu Ala Gin Pro Ser Gly Gly Ser Gly Gly Ser Gin Ser Phe

Leu Leu Lys Ser Leu Glu Gin Val Arg Lys lie Gin Gly Asp Gly

Ala Ala Leu Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His 25 Pro Glu Glu Leu Val Leu Leu Giy His Ser Leu Gly lie Pro Trp

Ala Pro Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly

Cys Leu Ser Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu

Leu Gin Ala Leu Glu Gly lie Ser Pro Giu Leu Gly Pro Thr Leu

Asp Thr Leu Gin Leu Asp Val Ala Asp Phe Ala Thr Thr lie Trp 30 Gin Gin Mec Giu Giu Leu Gly Met Ala Pro Ala Leu Gin Pro SEQ ID NO:438 31111. Pep 35 Ala Gly Asp Trp Gin Glu Phe Arg Giu Lys Leu Thr Phe Tyr Leu

Val Thr Leu Gl'a Gin Ala Gin Glu Gin Gin Gly Gly Gly Ser Giy

Gly Gly Ser Gly Gly Gly Ser Asn Cys Ser lie Met: lie Asp Glu lie lie His His Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro

Asn Asn Leu Asn Asp Glu Asp Val Ser lie Leu Met Asp Arg Asn 40 Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys Asn

Leu Glu Asn Ala Ser Gly lie Glu Ala lie Leu Arg Asn Leu Gin

Pro Cys Leu Pro Ser Ala Thr Ala Ala ?ro Ser Arg His Pro lie lie He Lys Tyr Val Glu Gly Glv GIv Gly Ser Pro Gly Glu Pro

Ser Gly Pro lie Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu 45 Ser His Lys Ser Pro Asa Met Ala Thr Gla Gly Ala Met Pro Ala

Phe Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala

Ser His Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg

His Leu Ala Gin Pro Ser Gly Giy Ser Gly Gly Ser Gin Ser Phe

Leu Leu Lys Ser Leu Giu Gin, Val Arg Lys lie Gin Gly Asp Gly 50 Ala Ala Leu Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His

Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp

Ala Pro Leu Ser Ser Cys Pro Ser Gin A丄a Leu Gin Leu Ala Gly

Cys Leu Ser Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Giy Leu

Leu Gin Ala Leu Glu Gly lie Ser Pro Glu Leu Gly Pro Thr Leu 55 Asp Thr Leu Gin Leu Asp Val Ala Asp Phe Ala Thr Thr lie Trp

Gin Gin Met Glu Giu Leu Giy Met Ala Pro Ala Leu Gin Pro SEQ ID NO:499 PMON15931 60

MetAlaAsnCysSerIleMetlleAspGIullelleHisHisLeuLysArgProProAla ProLeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsn LeuArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSer GlyILeG luAlalieLeuArgAsnLeuGlaProCysLeuProSerAlaThrAlaAlaPro 65 SerArgHis ProlleileileLysAlaGlyAspTrpGlnGiuPheArgGluLysLeuThr

PheTyrLeuVaiThrLeuGluGInAlaGlaGluGlnGlnTyrValGluGlyGlyGlyGly SerProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGlu SerHisLysSerProAsnMetAlaTyrLysLeuCysHisProGluGluLeuValLeuLeu GiyHisSerLeuGl，/IieProTrpAlaProLeuSerSerCysProSerGlr‘AlaLeuGln 70 LeuAidGlyCysLeuSerGinLeuHisSerGlyLeuPheLeuTyrGInGlyLauLeuGIn AlaLeuGiuGlylleSerProGluLeuGIyProThrLeuAspThrLeuGlnLeuAspVal AlaAspPheAlaThrThrIleTrpGinGlnMetGluGLuLeuGlyMetAlaProAlaLeu GlnProThrGlnGlyAlaMetProAlaPheAlaSerAlaPheGlnArgArgAlaGlyGly ValLeuValAlaSerHisLeuGlnSerPheLeuGluValSerTyrArgValLeuArgHis 75 LeuAlaG lnProGlyGlyGlySerAspMeCAlaThrProLeuGiyProAlaSerSerLeu

O:\92\92747.DOC 201 - 200413407

ProGlnSeirPheLeuLeuLysSerLeuGluGinValArgLysILeGinGiyAspGlyAla AlaLeuGlnGluLysLeuCysAlaThr SEQ ID NO：500 PMON15932 5

Me tAlaAs nCys S e r11eMe 111eAs pGluIlelieHisHis LeuLysArg P ro Pr oA1a ProLeuLeuAspProAsaAsnLeuAsnAspGluAspValS^rlleLeuMeCAspArgAsa LeuAirgLeuPiTQAsnijeuGluSerPheValAirgAlaValLysAsnLeuGluAsnAiaSer· GlvlieGluAlalieLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAiaPro 10 SerArgHis?roIlelielleLysAlaGiyAspTirpGlnGluPheArgGluLysLeuThr PheTyrLeuValThrLeuGluGlr^laGlnGluGlnGlnTyrValGluGlyGlyGlyGly SerProGlyGIuProSerGIyPrcIleSerThrIleAsnProSerProProSerLysGlu SerHisLysSerProAsriMetAIaProG iuLeuGlyProThrLeuAspThrLeuGlnLeu AspVaiAlaAspPheAlaThrThrlleTrpGlnGlriMetGluGluLeuGlyMetAlaPro 15 AlaLeuGlnProThrGlaGlyAlaMetProAlaPheAiaSerAlaPheGlnArgArgAla GiyGlyValLeuVal*MaSerHisLeuGInSerPheLeuGluValSerTyrArgVaiLeu ArgH i s LeuA1aG1η P r oG1yG i yG1vS e rAs pMe tAlaThrProLeuGlyPrcAiaSer SerLeuProGlnSerPheLeuLeuLysSerLeuGluGlnValArgLysIleGlaGlyAsp GlyAlaAlaLeuGlnGiuLysLeuCysAlaThrTyrLysLeuCysHisProGluGluLeu 20 ValLeuLeuGlyHisSerLeuGlylie?roTrpAia?roLeuSerSerCys?roSerGln AlaLeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSerGiyLeuPheLeuTyrGlnGly LeuLeuGlnAlaLeuGiuGiylieSer SEQ ID MO:501

PMON15965 25

MetAlaAsnCysSerlleMeclleAspGluIlelLeHisHisLieuIjysArgProProAla ProLeuLeuAspProAsnAsnLeuAsnAspGluAspValSer HeLeuMecAspArgAsn LeuArgLeuProAsnLeuGluSerPheValArgAiaValLysAsnLeuGiuAsnAlaSer GlylleGluAlalleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAiaPro 30 SerArgHisProIIellelieLysAiaGiyAspTrpGlnGluPheArgGIuLvsLeuThr ? heTvr L eu V a 1T h r L euG 1 uG I nA 1 aG 1 nG 1 uG i r.G 1 nTyr Va 1G1 uG lyG 1 yG ivG I y SerProGlyGluProSerGIyProIleSerThrIleAsaProSerProProSerLysGlu SerHisLysSerPrcAsnMetAiaSerAiaPheGlnArgArgAlaGlyGlyValLeuVal AlaSerHisLeuGlnSerPheLeuGluValSerTyrArgValLeuArgHisLeuAlaGln 35 ProGlyGlyGlySerAspMetAlaThrProLeuGlyProAlaSerSerLeuProGlnSer PheLeuLeuLysSerLeuGiuGlnValArgLysIIeGlnGiyAspGiyAlaAlaLeuGln GluLysLeuCysAlaThrTyrLysLeuCysHisProGiuGiuLeuValLeuLeuGlyHis SerLeuGlylieProTrpAlaProLeuSerSerCysProSerGinAlaLeuGlnLeuAla GlyCysLeuSerGinLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAiaLeu 40 GluGlylleSerProGluLeuGIyProThrLeuAspThrLeuGlnLeuAspValAlaAsp PheAlaThrThrlieTrpGlnGlrjyietGluGluLeuGlyMetAlaProAlaLeuGlnPro ThrGInG 1 yAlaMet:ProA1 aPheAla SEQ ID MO :502 OM0N15956 45

Me t A1 aAs nCy s SerlleMetll e As pGiuIielleHisHisLeuIjysArgPiroProAla ProLeuLeuAspProAsnAsnLeuAsriAspGIuAspValSer IleLeuMetAspArgAsn LeuArgLeuProAsnLeuGIuSer PheValArgAiaValLysAsnLeuGluAsnAlaSer GlylleGLuAla二 ieLeuAirgAsnLeupinPrcCysLeuPrcSerAlaThrAiaA丄aPro 50 S e rArgH isProlie I lelleLysAiaG 1 y As pT rpG i r.G lu PheArgG 1 uLys LeuThr

PheTyrLeuVaiThrLeuGiuGlnAlaGlriGluGInGlnTyrValGluGlyGlyGlyGl·/ SerProGlyGiuProSerGlyProIIeSerThrlleAsnProSerProProSerLysGlu SerHisLysSerProAsnMetAlaMecAlaProAlaLeuGinProThrGlnGlyAiaMet: ProAiaPheAlaSerAlaPheGlnArgArgAlaGlyGI'/'/aiLeuValAlaSerHisLeu 55 GinSer PheLeuGluVa iSerTyrArgValLe'jArgHisLeuAlaGlnProGlyG iyGly

SerAspMecAiaThrProLeuGlyProAlaSerSerLeuProGinSerPheLeuLeuLys SerLeuGluGlaValArgLysIleGlnGlyAscGlvAlaAlaLeuGlnGluLysLeuCys AlaThrTyrLysLeuCysHisProGluGIuLeuVaiLeuLeuGlyHisSerLeuGiylle ProTrpAlaProLeuSerSerCysProSerGIr^laLeuGlnLeuAlaGiyCysLeuSer 60 GlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlpJklaLeuGiuGlylleSer ProGluLeuG IvProThrLeuAs pThrLeuG in ύθαΑερ^ΜίΑίαΛ^Β p PheAl aThrThr 11eTrpG1nGInMetG1uGLuLeuG1y SEQ ID NO :503 、 DMON15967 65 ^

MetAlaAsnCy〇SerrieMecIleAspGlurielLeHisKisLeuLysArgProProAla ProLeuLeuAspProAsnAsnLeuAsnAspGLuAspVaiSer I leLeuMetAspArgAsn LeuArgLeuProAsnLeuGluSerPheVa LArgAiaValLysAsnLeuGluAsnAlaSei： Gly I ieG luA ialleLeuArgAsnLeuGlaProCysLeuProSerAlaThrAlaAlaPro 70 Ser ArqK i s ? rο I i e 11 e 11 eLvsAi aG iyAspTrpG l nG 1 u?heArgG IuLys LeuThr

PheTyrLeuVaiThrLeuGiuGlp^iaGlr.GluGlaGlnTyrValGluGlyGlyGlyGly SerProG LyGluProSerGlyPro IleSerThrIleAsnProSerProProSerLysGlu S e I* hi i :3 L y s S e i： P i: o A s ruM e c A1 a T h r G i n G i A 丄 d M e t: P ：： o A 丄 a P h e A JL a S e i* A1 a P h e _ GinArgArgAlaGLyGLyVaiLeuValAlaSerHisLeuGlnSerPheLeuGluValSer 75 TyrArgVaiLeuArgKisLeuAlaGlnProGlyGlyGlySerAspMetAlaThrProLeu

O:\92\92747.DOC -202- 200413407 G 丄yProAiaSerSerLeuProGLnSerPheLeuLeuLysSeirLeuGluGlriValArgLys IleGJLnGLyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThr^ryrLysLeuCyisHis ProGluGluLeuVaiLeuLeuGlyHisSerLeuGlylleProTrpAlaProLeuSerSer CysProSerGInAlaLeuGlnLeuAiaGlyCysLeuSerGlnLeuHisSerGlyLeuPhe LeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlyIleSerProGluLeuGiyProThrLeu AspThrLeuGlnLeuAspValAlaAspPheAlaThrThrlleTrpGlaGiaMetiGiuGlu LeuGI'y MecAiaProAlaLeuGlnPro SEQ ID NO : 504 10 pMON31112. pep

MetAlaiAsnCysSeirAsrLHetlleAspGluIlelleThrHisLieuI-ysGlnPrOPr'OIjeii ProLeuLeuAspPheAsrLAsnLeuAsnGiyGluAspGlnAspIleLeuMeCAspAsnAsn LeuArgArgProAsnLeuGluAlaPhsAsnArgAlaVaiLysSerLeuGlruXsnAlaSer 15 AlalieGluSerlleLeuLysAsnLeuLeuProCysLeuProLeuAlaThrAlaAlaPro ThrArgHisProIleHislleLysAspGlyAspTrpAsnGluPheArgArgLysLeuThr P heTyr L eu L ysThrL e uG1uAs rL^IaG i nA1aG1nG1nTyrVa1G1uG1yG1yG1yG1y SerPrcGlyGlu?::oSerGlyProIleSerThr IleAsnProSerPrroProSeirLysGiu SerHisLysSerProAsnMetiAlaThirGlnGlyAlaMetiPr'oAlaPheAlaSerAiaPhe 20 GlnArgArgAlaGlyGlyValLeuValAiaSerHisLeuGlnSerPheLauGluValSer TyrArgValLeuArgHisLeuAlaGlnProSerGiyGlySerGlyGlySerGlnSerPhe LeuLeuLysSerLeuGluGinValArgLysIleGinGlyAspGlyAlaAlaLeuGlnGlu LysLeuCysAlaThrTyrLysLeuCysHisProGluGiuLeuValLeuLeuGlyHisSer LeuGlylleProTrpAlaProLeuSerSerCysProSerGlnAlaLeuGlnLeuAlaGly 25 CysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGiaAlaLeuGlu GlylleSerProGiuLeuGlyProThrLeuAspThrLeuGinLeuAspVaiAlaAspPhe AlaThrThrIleTrpGlnGinWetGluGiuLeuGlyMetAiaProAiaLeuGlnPro SEQ ID MO：505" 30 PMON31II3.pep

Me 匕 A1aAs nCys Se rAs nMe t 工1eAspG 丄 u 工 l· e11eThrH i s L euLysG1n ? rο P r o L eu ProLeuLeuAspPheAsnAsnLeuAsnGlyGluAspGlnAspIieLeuMetGIuAsnAsn 35 LeuArgArgProAsnLeuGluAlaPheAsnArgAlaValLysSerLeuGlnAsnAlaSer AlaiieGiuSerlleLeuLysAsnLeuLeuProCysLeuProLeuAlaThrAlaAlaPro Thr Ar gH isPrcIlellell eArgAspG l'/AspT rp As nG 1 u PheAr gArgLys Leu.Thr PheTyrLeuLysThrLeuGi uAs nA i aG1nA1aG1nG1nTyrVaIG i uG1yG1yG1yG1y SerProGlyGiuProSerGlyProIleSerThrIleAsn?roSerPro?roSerLysGlu 40 SerHisLysSerPrcAsnMecAlaThrGlnGiyAlaMec?roAIa?heAlaSerAla?he GlnArgArgAlaGlyGlyValLeuValAiaSerHisLeuGin.SerPheLeuGluVaiSer TyrArgVaiLeuArgHisLeuAiaGlnProThrProLeuGlyProAlaSerSerLeuPro GlnSerPheLe ii Le uLys S e rLeuG i uG inVa lAr g Ly s 11 eG 1 nG 1 yAs pG 1 yAl aA 1 a LeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHisProGluGluLeuValLeuLeu 45 GlyHisSerLeuGlylleProTrpAlaProLeuSerSerCysProSerGlnAiaLeuGin. LeuAlaGlyCysLeuSerGlnLeuHisSerGiyLeuPheLeuTyrGlaGIyLeuLeuGlr, AlaLeuGiuGlyIleSerProGluLeuGlyProThrLeuAspThrLeuGinLeuAspVal AlaAspPheAiaThrThrlleTrpGlnGLriMecGiuGluLeuGiyMetAlaPrcAlaljeu GlnPro SEQ ID MO：50b ' > ^ 50 pMON31114. pep

Me tAIaAs nCys S e rAsnMe c11eAs pG1u11eIi eThr H i s Leu LysGIn ? r o ? r o Leu 55 ? r 〇 L e u L e u As p P h e As nAs n L e nG i y G i uA s pG 1 p 11 e L e uM e C G i u A s nA s n

LeuArgArgProAsnLeuGluAlaPheAsnArgAiaVaiLysSerLeuGlriAsnAlaSer AlaiLeGluSerIleLeuLysAsriLeuLeuPrcCysLeuPrcLeuAlaThrAlaAlaPro ThrArgHisProIiellelleArgAspGlyAspTrpAsnGIuPheArgArgLysLeuThr P h eTy r L e u L y s Th r Le uG1uAs aA i aG1nA1aG1nG1nTyrVa1G1uG1vG1yG i yGIy 60 SerProGLyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGlu

SerHisLysSerProAsruMetAiaThrGInGlyAlaMetProAiaPheAlaSerAlaPhe G1 nArqArgAlaG1yGlyValLeuValAlaSerHisLeuGInSerPheLeuGluVaiSer TyrArgValLeuArgHisLeuAlaGlnProSerGiyGlySerGlyGlySerGlnSerPhe _ LeuLeuLysSerLeuGluGlnValArgLvsIleGlnGlyAspGiyAiaAlaLeuGlnGlu 65 LysLeuCysAlaThrTyrLysLeuCysHisProGluGluLeuValLeuLeuGiyKisSer LeuGiyIleProTrpAlaProLeuSerSerCysProSerGInAiaLeuGlnLeuAlaGLy Cy s Leu S e rGInL s u H13 3 e rG1yL eu Ph e L euTyrG1nG1y L e u LeuG1nA1a Le uG1u Glyl leSer PrcGLuLeuGly ProThrLeuAspThrLeuGlxnLeuAspValAlaAspPhe AlaThrThr I leTrpGlnGlni-letGluGluLeuGiyMecAiaProAlaLeuGlnPro 70 5EQ ID MO：S07 pMOM3 i11S. pep

MecAlaAsnCysSerAsriMetIleAspGluIleiieThrHisLeuLysGlnProProLeu 75 PiroLeuLeuAspPheAsnAsnLeuAsnGiyGiuAspGiaAsp I LeLeuMetAspAsoAsn

O:\92\92747.DOC -203 - 200413407

LeuAr gAr g ? r oAs nLeuG 1 uA 1 a PheAs nAr gA i aVa 1 Ly s S e r Le uG I r.Al a Se r

Alai ieGluSer Γ leLieuLysAsnLeuLieuProCysLeuProLeuAiaThirAiaAlaPro ThrArgHis ?roI leHis I ieLysAspGiyAspTrpAsnGluPheArgArgL'/sLeuThr • PheTy f Ceu L./sThr LeuG luAsnAl aG 1 oAl aG 丄 nG i nT：/r Va 1G1 uG 1 yG i yrG i yG 1 y 5 SerProGlyGluProSerGiyProlieSerThrIleAsnProSerProProSerLvsGlu SerHisLy3Ser?roAsnMei:AiaThrGlnGlyAlaMec?roAlaPheAlaSerAia?he GlnArgArgAiaGIyGlyValLeuValAlaSerHisLeuCInSerPheLeuGluValSer TyrArgValLeuArgHisLeuAlaGlnProThrProLeuGlyPrcAlaSerSerLeuPro GlnSerPheLeuLeuLysSerLeuGiuGlnValArgLysIIeGlnGlyAspGiyAlaAla 10 LeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHisProGluGluLeuValLeuLeu GlyHisSerLeuGlylIe?roTrpAia?roLeuSerSerCy〇ProSerGlnAiaLeuGln LeuAlaGlyCysLeuSerGinLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGln AlaLeuGluGiyIleSerProGluLeuGlyProThrLeuAspThrLeuGinLeuAspVal A1 a As p ?he A1 aT hr Thr I i eT r pG 1 nG 1 nMe tG 1 uG 1 u LeuG 1 yMe C Al a ? r c Λ i a Leu 15 GlnPro SEQ ID N〇：508 ' ^ PHOM23505

20 AlaAsnCysSerlleMetlleAspGluIIelleHisHisLeuLysArgProProAlaPro L euL e u Asp P:: o As nAs nlj e uAs nAs pG i uAs pVa 1S e r 11 e L euMe t: As pArg As nL e u ArgLeuProAsnLeuGiuSerPheValArgAlaValLysAsnLeuGluAsriAiaSerGly IleGluAlalieLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer ArgHisProIlellelleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe 25 Ty r L e u Va 1 Th r L e uG 1 uG 1 nA 1 aG 1 nG i uG 1 nG 1 nTy r V a 1G1 uG 1 yG i y GI y G1 y S e r

ProGlyGluProSerGlyProIleSerThrIleAsn?roSer?roProSerL>ysGiuSer HisLysSerProAsnMetGiuValHisPrcLeuProThrProValLeuLeuProAlaVal AspPheSerLeuGI'/GluTrpLysThrGirJ^etGiuGluThrLysAiaGlnAspIIeLeu GlyAlaValThrLeuLeuLeuGluGlyValMetAlaAlaArgGlyGlnLeuGlyProThr 30 CysLeuSerSerLeuLeuGiyGlnLeuSerGlyGlnValArgLeuLeuLeuGiyAiaLeu GlnSerLeuLeuGlyThrGlnLeuProProGlP.GiyArgThrThrAlaHisLysAspPro AsnAla工lePheLeuSerPheGlnHisLeuLeuArgGlyL./sVaiArgPheLeuMetLeu ValGlyGlySerThrLeuCvsValArgGluPheGlyGlyAsnMetAiaSerProAlaPro ProAlaCysAspLeuArgValLeuSerLysLeuLeuArgAspSerHisVaiLeuHisSer 35 ArgLeuSerGlnCysPro SEQ ID NO509 PMOM23506

AlaAsnCysSerlieMetlleAspGluIlelleHisHisLeuLysArgProProAiaPro 40 LeuLeuAspProAsnAsnLeuAsnAspGluAspValSer工 ieLeuMetAspArgAsnLeu

ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGiy IleGluAialleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer ArgH i s ?r ο 11 e 11 e 11 e Ly s A1 aG I y AspT r pG I nG 1 u P he A.r gG 1 uLy s LeuThr Phe _ TyrLeuValThrLeuGluGlaAlaGlriGluGlnGlnTyrValGluGlyGiyGlyGiySer 45 ProQlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer

HisLysSerProAsnX^etLeuProThrProValLeuLeuProAiavalAspPheSerLeu G1yG1uT rpLy 3 T h rGInMetG1uG1uT h r Lys AIaG1 r^s p11eL euG i yAIaVaiThr LeuLeuLeuGluGly^/aiMecAlaAiaArgGlyGlnLeuGIyProThrCysLeuSerSer LeuLeuGiyGiaLeuSerGlyGiaVai'ArgLeuLeuLeuGlyAlaLeuGinSerLeuLeu 50 GlyThrGinLeuProProGlnGlyArgThrThrAiaHisLysAspProAsrL^IallePhe L e u S e r ? h e G1 π H i 3 L e u L e u A r g G1 y L y s V a 1Λ r g P h e L· e u M e C L e u V a i G1 y G1 y S e r ThrLeuCysVaiArgGIuPheGiyGlyAsr^IetAlaSerProAIaProProAIaCysAsp LeuArgValLeuSerLysLeuLeuArgAspSerHisVaiLeuHisSerArgLeuSerGIn Cys?roGLuVa1HisPro S5Q ID NO：5iO 55 pMOM235Q7

AlaAsnCysSerIleMecIieAspGluIleiLeHisKisLeuLysArgProProAlaPro L euL eu As p P r o As nAs nLeuAs rJ\spG i uAs p Va IS e r 11 eL euMe t: Asp Ar ς As nL eu 60 ArgLeu?roAsnLeuGluSer?heValArgAlaValLysAsnLeuGluAsr^IaSerGly I leGluAlaIIeLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAla?roSer ArgHis ?roliellelleLysAlaGlyAspTrpGlnGluPheArgGluLysLeu.ThrPhe Ty r Le u Va 1 Th r Le uG 1 uG I rJ\l aG 1 nG 1 uG 1 nG I nTy r Va 1G1 uG 1 yG 1 yG 1 yG I y S er ProGl'/GluProSerGlyPfoIleSerThrlLeAsnProSerProProSerLysGiuSer 65 HisLysSerP r oAsnMe cVa1LeuLeu P roA1aVa1As p P he S er LeuG1yG1uT rp Lys

ThrGlnMe tGluGIuThrLysAlaGlnAspIXeLeuGlyAlaValThrLeuLeuLeuG iu GlyVaiMetAiaAlaArgGlyGInLeuGlyProThrCysLeuSerSerLeuLeuGlyGin LeuSerGlyGInValArgLeuLeuLeuGlyAlaLeucinSerLeuLeuGiyThrGlnLeu P ro ? r oG1nGIyArgThrTh rA1aH i s Lys As p P r oAs nA iallePheLeuSerPheGin 70 H i s Leu Le u A r gG I y Ly s Va i A r g Phe LeuMe t L eu '/a IG1 yG 1 y S e rThr LeuC y s Va 1

ArgGluPheGiyGlyAsruMecAlaSerProAlaPro ProAlaCysAspLeuArgVaiLeu SerLys LeuLeuArgAspSerHisValLeuHisSerArgLeuSerGlnCys ProGluVal HisProLou?roThrPro SEQ ID NO :511 75 pMON2R503

O:\92\92747.DOC -204- 200413407

AlaAsnCysSer Σ ieMe 11 leAspGluIlel leHisHisLeuLysArgPi：Q?rc)AlciPro LeuLeuAspProAsnAsnLeuAsnAGpGluAspValSerIleLeuMetAspArgAsnLeu • ArgLeuProAsnLeuGluSerPheVaiArgAlaValLysAsnLeuGluAsnAlaSerGL·/ 5 工 leGiuAlalleLeuArgAsnLeuGlnProCysLeuPiroSerAlaThrAlaAlaProSe]： ArgHisProIlellelIeLysAlaGlyAspTrpGln.Glu?heArgGluLysLeuThrPhe TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGivGlySer ProGiyGLuProSerGIyProIieSerThrIleAsnProSerProProSerLysGluSer HisLysSerProAsnMecAlaValAspPhsSerLeuGlyGluTrpLysThrGlnMetGiu 10 GluThrLysAlaGinAspIieLeuGiyAlaValThrLeuLeuLeuGluGlyValMetAla AlaArgGlyGlnLeuGIyProThrCysLeuSerSerLeuLeuGlyGlnLeuSerGlyGln ValArgLeuLeuLeuGlyAiaLeuGinSerLeuLeuGlyThrGlnLeuProProGinGly ArgThrThrAiaHisLysAspProAsnAlallePheLeuSerPheGlnHisLeuLeiL^rg GiyLysValArgPheLeuMetLeuValGlyGlySerThrLeuCysValArgGluPheGly 15 GlyAsn：^etAlaSerProAla?ro?roAlaCysAspLeuArgVaiLeuSerLysLeuLeu ArgAspSerHisVaiLeuHisSerArgLeuSerGlnCysProGluVaiHisProLeuPro ThrProValLeuLeuPro SZQ ID NO:512 一 PMON23509 20

AlaAsnCysSerIleMe匕工leAspGiullellsHisHisLeuLysArgProProAlaPro LeuLeuAspProAsnAsnLeuAsnAspGiuAspValSerlleLeuMetAspArgAsnLeu ArgLeuProAsHLeuGluSerPheValArgAlaValLysAsaLeuGluAsnAlaSerGly IleGluAlalleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer 25 ArgHisProIlellelleLysAlaGiyAspTrpGlnGluPheArgGluLysLeuThrPhe TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGiuGlyGlyGlyGiySer ProGlyGiuProSerGlyProIleSerThrlleAsnProSerProProSerLysGluSer KisLysSerProAsnMetAspPheSerLeuGlyGluTrpLysThrGlnMetGluGiuThr LysAlaGlnAspIleLeuGiyAlaValThrLeuLeuLeuGiuGlyValMetAlaAlaArg 30 GlyGlnLeuGlyProThrCysLeuSerSerLeuLeuGlyGlnLeuSerGlyGlnValArg LeuLeuLeuGIvAlaLeuGlnSerLeuLeuGlyThrGlnLeuProProGlnGlyArgThr ThrAlaHisLysAspProAsnAlallePheLeuSerPheGlnHisLeuLeuArgGlyLys ValArgPheLeuMeCLeuValGlyGlySerThrLeuCysValArgGluPheGiyGlyAsn MetAlaSerProAia?rc?roAlaCysAspLeuArgValLeuSerLysLeuLeuArgAsp 35 SerHisValLeuHisSerArgLeuSerGlnCysProGIuVaiHisProLeuProThrPro ValLeuLeuProAlaVai SEQ ID NO:513 PMON2S510

40 AlaAsnCysSerlleMecIieAspGluIlelleHisHisLeuLysArgProProAlaPro LeuLeuAspProAsnAsnljeuAsnAspGluAspValSerlleLeuMeCAspArgAsnLeu ArgLeuProAsnLeuGluSerPheVaiArgAlaValLysAsnLeuGluAsnAiaSerGIy IleGluAlalleLeuArgAsnLeuGInProCysLeuProSerAlaThrAlaAiaProSer ArgHisProIIelleileLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe 45 TyrLeuValThrLeuGluGlrLAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer ProGlyGluProSerGlyProIleSerThrIleAsnProSerPr〇ProSerLysGluSer HisLysSar ProAsnMetGlyGluTrpLysThrGlnMetGluGluThrLysAlaGlpJ^.sp IleLeuGIyAiaVaiThrLeuLeuLeuGIuGlyValMetAlaAlaArgGlyGinLeuGly ProThrCysLeuSerSerljeuLeuG丄yplnLeuSerGlyGlnValArgLeuLeuLeuGiy 50 AlaLeuGlnSerLeuLeuGlyThrGlnLeuProProGlnGlyArgThrThrAiaHisLvs AspPrcAsnAlallePheLeuSerPheGlnHisLeuLeuArgGiyLysVaiArgPheLeu Me t L eu Va IG1 y G X y S e r T h r L euCy s V a 1 Ar gG 1 u ? h eG I yG 1 y As ni4e t A i a S e r P r o AlaProPrcAlaCysAspLeuArgValLeuSerLysLeuLeuArgAspSerHisValLeu HisSerArgLeuSerGinCysProGluValHisProLeuProThrProValLeuLeuPro 55 AlaValAspPheSerLeu SEQ ID NO:514 pMOM235ii

AlaAsnCysSerIleMetILeAspGluIleiieHisKisLeuLysArgProProAiaPro 60 LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerlieLeuMetAspArgAsnLeu ArgLeuPrcAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAiaSerGly 工 leGluAlal ieLeuAjrgAsnLeuGlnPrcCysLieuProSerAiaThrA^aAlaProSer ArgHis ProllelleiieLysAlaGiyAspTrpGinGluPheArgGluLisLeuThrPhe TyrLeuVaiThrLeuGluGip^laGlnGluGlnGinTyrValGluGlyGlyGiyGlySer 65 ProGlyGiuProSerGlyProlieSerThrIleAsnProSerProProSerLysGluSer HisLysSer ProAsrU^tecGlyProThrCysLeuSerSerLeuLeuGlyGinLeuSerGly GlnVa LArgLeuLeuLeuGlyAlaLeuGlnSerLeuLeuGiyThrGlnLeuProProGla GlyArgThrThrAiaHisLysAspProAsnAlallePheLeuSerPheGLnHisLeuLeu ArgGiyLysValArgPheLeuMecLeuValGlyGlySerThrLeuCysValArgGluPhe 70 G1yG1yAs nMe C AIaS e r P r oA1a P r o Pr oA1aCy s As p LeuArg Va1LeuSer Lys Leu

LeuArqAspSerKisValLeuHisSerArgLeuSerGlnCysProGiuValHisProLeu ProThr ProVa iLeuLeu?roAlaVr3.lAspPheSerLeuGlyGlaTrpLysThrGln!4et GI uG 1 uT h r Ly 3 A1 aG 1 p I i e LeuG i y Λ1 a Va 1 Th r L eu Leu LeuG 1 uG 1 y V a 1 Me t

AlaAlaAraGivGlnLeu SEQ ID MO:515 75 ^

O:\92\92747.DOC 205 - 200413407 pMON2 3 512

AlaAsnCysSerlleMetIleAspGluIlelieHisHisLeuLysArgProPiroAlaPro LeuLeuAspProAsoAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeu

HeGluAlaneLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer ArgHis Pro IiellelleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGIyGivGlyGlySer ProGiyGluProSerGiyProlleSerThrIleAsnProSerProProSerLysGluSer 10 HisLysSer PrcAsnMetG 丄'/ThrGlnLeu?roPr〇GlnGlyAxgTh::ThrAlaHisLys

AspProAsnAlaliePheLeuSerPheGlnHisLeuLeuArgGlyLysValArgPheLeu MetLeuValGlyGlySerThrLeuCysValArgGluPheGlyGlyAsnWetAlaSerPro AlaProProAlaCysAspLeuArgValLeuSerLysLeuLeuArgAspSerHisValLeu HisSerArgLeuSerGlnCysProGluValHis ProLeuProThrProValLeuLeuPro 15 AlaValAspPheSerLeuGIyGluTrpLysThrGlaMetGIuGluThrLysAlaGlnAsp IleLeuGlyAlaValThrLeuLeuLeuGluGlyValMetAlaAlaArgGlyGinLeuGiy ProThrCysLeuSerSerLeuLeuGlyGlnLeuSerGlyGinValArgLeuLeuLeuGly AlaLeuGlnSerLeuLeu SSQ ID MO：516 20 pMON23513

AlaAsnCysSer工leMetIleAspGluIleIleHisHisLeuLysArgPrc?roAlaPro Ι^θΐιΙ^θυΑ5ρΡ：!：〇Α5ηΑ5ηΙ^θΐιΑ5ηΑ5ρ01ΐ·ΐΑ5ρ\/αΐ5«52：Ι1θΙαθΐιΜθ=Α3ρΑι：9Α5ηΙ^θΐ·ΐ

ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly 25 IleGluAlalleLeuArgAsnLeuGinProCysIjeiiProSerAlaThrAlaAlaProSer ArgHisProIlelielleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe TyrLeuVaiThrLeuGluGlaAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer ProGiyGluProSerGlyProIieSerThrlleAsnProSerProProSerLysGluSer HisLysSerProAsnMetGlyArgThrThrAlaHisLysAspProAsnAlaliePheLeu 30 SerPheGlnHisLeuLeuArgGlyLvsValArgPheLeuMecLeuValGlyGlySerThr LeuCysValArgGluPheGlyGlyAsnMetAlaSerProAIaProProAiaCysAspLeu ArgVaiLeuSerLysLeuLeuArgAspSerHisValLeuHisSerArgLeuSerGlnCys ProGluVaiHisProLeuProThrProValLeuLeuProAlaValAspPheSerLeuGly GluTrpLysThrGlnMeCGluGluThrLysAlaGliiAspIleLeuGlyAlaValThrLeu 35 LeuLeuGiuGiyValMetAlaAlaArgGlyGlnLeuGlyProThrCysLeuSerSerLeu LeuGlyGlnLeuSerGlyGlnValArgLeuLeuLeuGlyAiaLeuGlnSerLeuLeuGly ThrGlnLeuProProGln SEQ ID NO:517 PMON28514 40

AlaAsnCysSerlleMecIieAspGiullelleHisHisLeuLysArgProProAlaPro LeuLeuAspProAsnAsnLeuAsriAspGiiiAspValSerlleLeuMetAspArgAsr.Leu ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly IleGluAlalleLieuArgAsnLeuGlnProCysLeuProSerAiaThrAlaAiaProSer 45 ArgHisProIlellelleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe TyrLeuVaiThrLeuGIuGinAlaGlnGluGlnGlnTyrValGluGiyGlyGlyGlySer ProGlyGluProSerGIyProIleSerThrlieAsnProSerProProSerLysGluSer HisLysSerProAsnMecAlaHisLysAspProAsnAlallsPheLeuSerPheGinHis LeuLeuArgGlyLvsValArgPheLeu^etLeuValGlyGlySerThrLeuCysValArg 50 GiuPheGiyGiyAsnMeCAlaSerProAlaProProAlaCysAspLeuArgValLeuSer LysLeuLeuArgAspSerHi3ValLeuHisSerArgLeuSerGln.Cys ProGluValHis ProLeuProThrProValLeuLeuProAlaValAspPheSerLeuGlyGluTrpLysThr G1 ni4e cG 1 uG 1 uT h r L y s A1 aG 1 nAs p 11 e L e uG 1 y Λ1 a Va 1T h r L e uL eu L euG 1 uG 1 y ValMecAjLaAlaArgGlyGlnLeuGlyPrroThrCysLeuSerSerLeuLeuGiyGlnLeu 55 SerGlyGlnValArgLeuLeuLeuGlyAlaLeuGinSerLeuLeuGlyThrGlnLeuPro ?roGinGIyArgThrThr SEQ ID MO:513 PMOM23515 60 AlaAsnCysSerIleMecIleAspGluIleileHisHisLeuLysArgPrcProAlaPro LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMecAspArgAsnLeu ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAiaSerGly IleGluAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer ArgHisPiroIlellel leLysAlaGlyAspTrpGlnGluPheArgGluLysLeu.ThrPhe 65 TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGiuGlyGlyGlyGlySer ProGlyCUuPrOSerGlyProIleSeirThr J；；LeAsnPr〇SerP!：oPr〇SerLysGiuSei： HisLysSerProAsnMetAspProAsnAlalLePheLeuSerPheGlnHisLeuLeuArg GlyLysValArgPheLeuMetLeuValGlyGlySerThrLeuCysValArgGluPheGly GlyAsnMecAlaSerProAlaProProAlaCysAspLeuArgValLeuSerLysLeuLeu 70 ArgAspSerHisValLeuHisSerArgLeuS^rGinCygProGluValHisProLauPro ThrProVa J*LeuLeuProAla\/alAspPheSerLeuGlyGluTrpLysThrGiruMetGlu G I_uThi:Ly3 AlaGiaAsp 工 leLeuG LyAiaValThzrLeuIjeuLeuGluG lyValMecAla AlaArgGlyGinLeuGiyProThrCysLeuSerSerLeuLeuGlyGlnLeuSerGlyGln ValArgLeuLeuLeuGlyAlaLeuGlnSerLeuLeuGlyThrGlaLeuProProGlnGly 75 ArgThrThrAlaHisLys SEQ ID NO:519

O:\92\92747.DOC -206- 200413407 ΌΜΟΝ285Ι6

AlaAsnCysSer:工 leMecileAspGiullel leHisHisLeuLys ArgProPr〇AlaP]：〇 5 LeuLeuAspProAsnAsnjLeuAsnAspGluAspValSezrlleLeuMetAspAirgAsnLeu ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsoAlaSerGly IleGluAlalleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer ArgHisProIlellelleLysAlaGlyAspTrpGlnGluPheArgGluLysueuThrPhe TyrLeuValThrLeuGlaGlnAlaGlnGiuGlnGl^TyrValGluGlyGlyGlyGlySer 10 ProGlyG!luProSe2：GlyProIieSe2：Th;rIleAsnPr〇SerP:r〇Pr*〇SeirL)ysGluSer' HisLysSerProAsnMetAlallePheLeuSerPheGlnHisLeuLeuArgGiyLysVal ArgPheLeuMetLeuValGlyGlySerThrLeuCysVaiArgGluPheGlyGlyAsnMet: AlaSerProAlaProProAiaCysAspLeuArgValLeuSerLysLeuLeuArgAspSer HisValLeuHisSerArgLeuSerGlnCysProGluValHisProLeuProThrProVal 15 LeuLeuProAiaValAspPheSerLeuGlyGluTrpLysThrGlnWetGluGIuThrLys AlaGlnAspIleLeuGlyAlaValThrLeuLeuLeuGluGlyValMetAlaAlaArgGiy GlnLeuGlyProThrCysLeuSerSerLeuLeuGlyGlnLeuSerGlyGInValArgLeu LeuLeuGlyAlaLeuGlnSerLeuLeuGlvThrGlnLeuProProGlnGlyArgThrThr AlaHisLvsAsoProAsn SEQ ID MO:520 20 ^ ' pM〇N28519

AlaAsnCysSer'IleMeClleAspGluIlelieHisHisLeuLysArgProProAlaPro LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerl leLeuMetAspArgAsnLeu 25 ArgLeuProAsnLeuGluSerPheValArgAla'/alL^/sAsnLeuGluAsnAJLaSerGly IlsGluAlalleLeuArgAsnLeuGlaProCysLeuProSerAlaThrAlaAlaProSer ArgHis ProIiellelleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe TyrLeuValThrLeuGiuGlnAlaGLnGluGinGlnTyrValGluGlyGlyGlyGlySer i ProGlyGiu?roSerGIy?roIleSerThrIleAsnProSerProProSerLysGluSer 30 Ηΐ3Εγ5 5θ2：Ρ2：οΑ3ηΜθ^(31ι：ν·5ΐΐΗ:ΐ3Ρ2：οΓαβυΡχ·〇ΤΐΊ；Σ：Ρζ:〇ν^1Ι)0ΐιΙ*θΐιΡΓ·〇Αΐδν^1

AspPheSerLeuGlyGluTrpLysThrGlnMetGiuGluThrLysAlaGlnAspIleLeu GlyAlaValThrLeuLeuLeuGluGlyValMetAlaAIaArgGlyGlnLeuGlyProThr CysLeuSerSerLeuLeuGiyGlnLeuSerGlyGlnValArgLeuLeuLeuGlyAlaLeu GlnSerLeuLeuGlyThrGInLeuProPrcGlnGlyArgThrThrAlaHisLysAspPro 35 AsaAlallePheLeuSerPheGlnHisLeuLeuArgGlyLysValArgPheLeuMetLeu ValGiyGlySerThrLeuCysValArgGluPheGlyAsaMetAlaSerProAiaProPro AlaCysAspLeuArgValLeuSerLysLeuLeuArgAspSerHisValLeuHisSerArg LeuSerGlnCysPro SEQ ID NO:521 40 pMON2S520

AlaAsnCysSerlleMetlieAspGluIlelleHisHisLeuLysArgProProAlaPro LeuLeuAspProAsnAsnLeuAsnAspGluAspVaiSer IleLeuMetAspArgAsnLeu _ ArgLeu?roAsnLeuGluSer?heValArgAlaValLysAsnLeuGluAsrJ\laSerGly 45 IleGluAlalleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer ArgHisProIIellelieLvsAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe TyrLeuValThrLeuGluGiaAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer ProGIyGiuProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer HisLysSer ProAsn>Iet:LsuProThr ProVaiLeuLeuProAlaValAspPheSerLeu )0 GlyGluTrpLys'ThrGlnMetGliiGluYhrL./sAlaGlnAspIleLeuGlyAlaValTh:: LeuLeuLeuGIuGlyValMetAlaAiaArgGIyGlnLeuGlyProThrCysLeuSerSer LeuLeuG 1 yGlaLeuSerGiyGlnValArgLeuLeuLeuGlyAlaLeuGinSerLeuLeu GlyThrGlnLeuProProGlnGlyArgThrThrAlaHisLysAspProAsnAlallePhe _ LeuSerPheGlnHisLeuLeuArgGlyLysValArgPheLeuMetLeuValGiyGlySer 55 ThrLeuCysValArgGluPheGlyAsnMe tAlaSer?roAla?roProAlaCysAspLeu ArgValLeuSerLyGLeuLeuArgAspSerHisValLeuHisSerArgLeuSerGlnCys ProGluValHisPro SEQ ID MO：522 DMON23521 60

AlaAsnCysSerIleMeLlieAspGluIlelleHisHisLeuLysArgProProAlaPro LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerl leLeuMetAspArgAsnLeu ArgLeuProAsnLeuGluSerPheVaiArgAlaValLysAsnLeuGluAsnAlaSerGIy IleGluAlalleLeuArgAsnLeuGInProCysLeuProSerAlaThrAlaAlaProSer 65 ArgHisProIIslielleLysAlaGlyAspTrpGlnGluPneArgGluLysLeuThrPhe TyrLeuValThrLeuGluGInAlaGlnGIuGlnGlnTyrValGluGlyGlyGlyGlySer ProGlyG LuProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer HisLysSer ProAsnMetVa lLeuLeuProAlaValAspPheSerLeuGlyGluTrpLys ThirG 1 oMe LG iiiG LuThrlz/s Ai aG 1 nAsp I： 1 eLeuG 1 yA丄 aVa iThirLeuLeuLeuG 1 u 70 GlyVaiMecAieiAlaArgGiyGinLeuGlyProThrCysLeuSerSerLGuLeuGjLyGin LeuSerG lyGlnValArgLeuLeuLeuGlyAlaLeuGlnSerLeuLeuGlyThrGlnLeu ProProG i:飞G L'/ArrgThirThrALaHisLysAspPiroAsnAlal lePheLeuSerPheGln HisLeuLeuArgGlyLysValArgPheLeuMetLeuValGlyGlySerThrLeuCysVal ArgGiuPheGlyAsnMetAlaSerProAlaProProAlaCvsAspLeuArgValLeuSer 75 LysLeuLeuArgAspSerHisValLeuMisSerArgLeuSerGInCys ProGiuValHis O:\92\92747.doc -207- 200413407

ProLeuProThrPro SEQ ID NO：523 PMON28522 5 AlaAsnCysSerrlleMetlleAspGluIleileHisHisLeuLysArgProProAlaPro LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerlleLeuMetAspArgAsnLeu ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly IleGluA 丄 al Α：Γ9Ηΐ5?2：〇Ι；ΐ0ΐ1βΙΐ0ΐ//3Αΐ3〇1'/Α3ρΤΓρΟ1ηαΐιιΡΙΐθΑΓ9〇1ιιΙ//3[^ιιΓΓΗΓΡΐ^ 10 TyrLeuValThrLeuGluGlnAlaGlnGliuGlnGinTyrValGluGlyGlyGlyGlySer ProGlyGiuProSerGiyProIleSerThrIIsAsnProSerProProSerLysGluSer HisLysSer ProAsnl^letAiaValAspPheSerLeuGlyGluTrpLysThrGlrLMe tGlu GluThrLysAlaGlnAspIleLeuGlyAlaValThrLeuLeuLeuGluGlyValMetAla AlaArgGlyGinLeuGiyProThrCysLeuSerSerLeuLeuGlyGlnLeuSerGlyGln 15 ValArgLeuLeuLeuGlyAlaLeuGlnSerLeuLeuGlyThrGlnLeuProProGlnGly ArgThrThrAlaHisLysAspProAsnAlallePheLeuSerPheGlnHisLeuLeuArg GlyLysValArgPheLeuMecLeuValGlyGlySerThrLeuCysValArgGiuPheGly AsnMeCAlaSerProAlaProProAlaCysAspLeuArgValLeuSerLysLeuL^uArg AspSerHisValLeuHisSerArgLeuSerGlnCysProGluVaiHisProLeuProThr 20 ProValLeuLeuPro SEQ ID NO：524 pMON2 8 5 2 3

AlaAsnCysSerIleMetlleAspGluIlelleHisHisLeuLysArgProProAlaPro 25 LieuLeuAspProAsnAsnLeuAsnAspGluAsp’N/alSeirlleLeuMeuAspArgAsnLeLi ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGiuAsnAlaSerGly IleGluAlalleLeuArgAsnljeuGlnProCysLeLiProSerAlaThrAlaAlaProSer ArgHisPr〇IleIleIleLysAlaGlyAspTrpGlnGluPheArgGluLysL<euThrPhe TyrLeuValThrLeuGluGir^iaGlnGiuGinGlnTyrValGluGlyGlyGlyGiySer 30 ProGlyGluProSerGlyProlieSerThrIleAsnProSerProProSerLysGluSer HisLysSerProAsnMecAspPheSerLeuGlvGluTrpLysThrGlaMecGluGluThr LysAlaGlnAspIleLeuGlyAlaVaiThrLeuLeuLeuGluGlyValMetAIaAlaArg GlyGinLeuGlyProThrCysLeuSerSerLeuLeuGlyGlnLeuSerGlyGinValArg LeuLeuLeuGlyAlaLeuGlnSerLeuLeuGlyThrGlnLeuProProGinGiyArgThr 35 ThrAlaHisLysAspPrcAsnAlallePheLeuSerPheGlnHisLeuLeuArgGlyLys ValArgPheLeuMetLeuValGlyGiySerThrLeuCvsValArgGluPheGlyAsnMet AlaSerProAlaProProAlaCysAspLeuArgValLeuSerLvsLeuLeuArgAspSer HisVaiLeuHisSerArgLeuSerGlnCysProGluValHisProLeuProThrProVal LeuLeuProA丄aVal SEQ ID NO:525 40 PMON23524

AlaAsnCysSer I ieMet I leA.spGluIIe I leHisKisLeuLysArgPro ProAiaPro LeuLeuAspProAsnAsnLeuAsnAspGluAspValSer IleLeuMetAspArgAsnLeu 45 ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly IleGluAial leLeuArgAsnLeuGlnProCysLeuProSerAlaThrAiaAiaProSer ArgHisProIlellelleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGiyGiyGiyGlySer ProGlyGluProSerGlyProI leSeriThrlleAsnProSerProProSerLysGiuSer. 50 HisLysSer ProAsnl^letGlyGluTrpLysThrGlriMetGluGluThrLysAiaGinAsp 工 1 e L· e uG 1 y A i a Va 1T h r L e u L< «e u L e uG 1 uG 1 y'/a 1 Me t: A1 a A1 a Ar gGl y G1 n L e uG 1 y ProThrCysLeuSerSerLeuLeuGlyGlnLeuSerGlyGlnValArgLeuLeuLeuGly AlaLeuGinSerLeuLeuGlyThrGlnLeuProProGlnGlyArgThrThrAlaHisLys AspProAsnAlallePheLeuSerPheGlnHisLeuLeuArgGlyLysValArgPheLeu 55 MetLeuValGIyGlySerThrLeuCysValArgGiuPheGiyAsoMetAiaSerProAla ProProAlaCysAspLeuArgVaiLeuSerLysLeuLeuArgAspSerHisValLeuHis SerArgLeuSerGlnCys?roGiuValHis?roLeuProThrProVaiLauLeuProAla ValAspPheSerLeu SEQ ID NO :526 60 DMON23525

AlaAsnCysSerIleMetIieAspGluIleileHisHisLeuLysArgProProAiaPro LeuLeuAspProAsnAsnLeuAsnAspGluAspValSer IleLeuMetAspArgAsnLeu ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly 65 IleGiuAlal leLeuArgAsnLeuGlnPrroCyslieuProSeirAlaThrAlaAiaProSer ArgHisProIleilelleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValG.luGlyGlyGlyGlySer ProGlyGlu? roSerGiy?roIleSerThrILeAsnProSerProProSerLysGluSer HisLysSerProAsnMetGlyProThrCysLeuSerSerLeuLeuGlyGlnLeuSerGly 70 GlaValArgLeuLeuLeuGlyAlaLeuGlnSerLeuLeuGlyThrGlnLeuProProGln GlyArgThrThrAiaHisLysAspProAsnAiallePheLeuSerPheGlnHisLeuLeu ArgGlyLysValArgPheLeuMecLeuValGlyGlySerThrLeuCysValArgGluPhe GlyAsnMecAlaSerPro AlaProProAlaCysAspLeuArgValLeuSerLysLeuLeu ArgAspSerH i sVaILeuHisSerArgLeuSerGInCys ProGluValHi 3 ProLeuPro 75 ThrPiroVa iLeuLeuProA丄 dV.alAspPheSerLeuGlyGluTrpLysThrGinMetGiu

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GluThrLysAlaGJLnAspI LeLeuGlyAiaValThirLeuLeuLeuGluGlyValMetAla AlaArgGlyGlnLeu SEQ ID N〇：527 DMON235265 AlaAsnCysSerIleMetlieAspGluIielleHisHisLeuLysArgProProAlaPro LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeu ArgLeuPiroAsnLeuGluSerPhe'/aiArgAlaVa 丄 LysAsnLeuGluAsnAlaSerGly 工 leGJLuAlalleLeuArgAsnLeuGinPiroCysLeuProSerAlaThrAlaAlaProSeir 10 ArgHisProIlelLelleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe TyrLeuValThrLeuGluGloAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer ProGlyGiuProSerGlyProIleSerThrXleAsnPrcSerProProSerLysGluSer HisLysSerProAsniMetGlyThrGlnLeuProProGlnGlyArgThrThrAlaHisLys AspProAsnAlaliePheLeuSerPheGinHisLeuLeuArgGlyLysValArgPheLeu 15 MeCLeuValGlyGlySerThrLeuCysVaiArgGluPheGiyAsnMetAlaSerProAla ProProAlaCysAspLeuArgValLeuSerLvsLeuLeuArgAscSerHisValLeuHis SerArgLeuSerGinCysProGluValHisProLeuProThrProValLeuLeuProAla ValAspPheSerLeuGiyGluTrpLysThrGlnMetGluGLuThrLysAlaGlnAspIle LeuGlyAlaValThrLeuLeuLeuGiuGiyValMetAlaAlaArgGlyGInLeuGlyPro 20 ThrCysLeuSerSerLeuLeuGlyGlnLeuSerGlyGlnValArgLeuLeuLeuGlyAla LsuGlnSsirLeuLeu SEQ ID MO :528 PMON2S527 AlaAsnCysSerIleMetIleAspGluIielieHisHisLeuLysArgProProAlaPro LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIieLeuMeCAspArgAsnLeu ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGiijAsnAlaSerGly IleGluAlalleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer ArgHisProliellelleLysAlaGlyAspTrpGinGluPheArgGiuLysLeuThrPhe TyrLeuValThrLeuGiuGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer ProGlyGiuProSerGlyProIleSerThrlleAsnProSerProProSerLysGluSer HisLysSerProAsnMetGlyArgThrThrAlaHisLysAspProAsrJMaXIePheLeu SerPheGlnHisLeuLeuArgGlvLysValArgPheLeuMecLeuValGlyGlySerThr LeuCysValArgGluPheGlyAsnMetAlaSerProAlaProProAlaCysAspLeuArg ValLeuSerLysLeuLeuArgAspSerHisValLeuHisSerArgLeuSerGInCysPro GluValHisProLeuProThrProValLeuLeuProAlaValAspPheSerLeuGlyGlu TrpLysThrGlnMetGluGIuThrLysAlaGlnAspIieLeuGlyAlaValThrLeuLeu LeuGluGlyValMetAlaAlaArgGiyGlnLeuGlyProThrCysLeuSerSerLeuLeu GlyGlnLeuSerGlyGlnValArgLeuLeuLeuGlyAlaLeuGlnSerLeuLeuGlyThr GlnLeuProProGln SEQ ID NO :529 PMON23523 AlaAsnCysSerlleMecIIeAspGlulieIIeHisKisLeuLysArgPrc?roAla?ro LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeu ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAiaSerGly IleGluAlalleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAiaAlaProSer ArgHisProIlellelleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe TyrLeuValTh rL euG1uG1nAlaG1nS1uG1nG1nTyrVa1G1uG1yGlyG i yG1yS e r ProGIyGIuProSerGlyProIIeSerThrlleAsnProSerProProSerLysGluSer HisLysSerProAsnMetAiaHisLysAspProAsnAlallePheLeuSerPheGlnHis LeuLeuArgGlyLysValArgPheLeuMecLeuVaiGlyGlySerThrLeuCysValArg GluPheGlyAsnMetAlaSerProAlaProProAlaCysAspLeuArgValLeuSerLys LeuLeuArgAspSerHisValLeuHisSerArgLeuSerGlnCysProGluValHis Pro LeuProThrProValLeuLeuProAiaValAspPheSerLeuGlyGIuTrpLysThrGin Me tG1uGIuThr Lys A1aG1nAs p11eLeuG1vA1aValThrLeuLeuLeuGluGlyVaI MetAlaAlaArgGlyGlnLeuGlyProThrCysLeuSerSerLeuLeuGlyGlriLeuSer GlyGlnValArgLeuLeuLeuGlyAlaLeuGlnSerLeuLei:GlyThrGlnLeuP]：cPr*o GlnGlyArgThrThr SEQ ID NG:530 PMON23529 AlaAsnCysSerIleMetI1eAspGluIleiIeHisHisLeuLysArgProProAlaPro LeuLeuAspPrroAsrLAsnLeuAsnAspGluAspValSerlleLeuMetAspArgAsnLeu ArgLeuProAsnLeuGluSerPheValArgAlaValLvsAsnLeuGluAsnAlaSerGly IleGluAlalLeLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer ArgHisProl leiielleLysMaGiyAspTirpGlnGluPheArgGluLysLeuThr Phe Ty r Le u Va IT hr LeuG 1 uG 1 nA 1 aG i nG 1 uG I r.G 1 nTy r Va 1G1 uG 1 yG1 yG1 yG1 y S e r ProGIyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGiuSer HisLysSerProAsnMecAspProAsnAlaliePheLeuSerPheGlnHisLeuLeuArg GlyLysValArgPheLeuMecLeuValGlyGlySerThrLeuCysValArgGluPheGly AsnMetAiaSerProAlaProProAlaCysAspLeuArgValLeuSerLysLeuLeuArg AspSerHisVaiLeuHisSerArgLeuSerGlaCys ProGl'iValHis ProLeuProThr ProValLeuLeuProAlaValAspPheSerLeuGlyGiuTrpLysThrGlrLMecGluGlu 75 ThrLysAlaGlaAspIleLeuGlyAlaValThrLeuLeuLeuGluGlyVaiMecAlaAla 25

30 35 40 45 50

55 60

O:\92\92747.DOC -209- 200413407

ArgGiyGlnLeuGlyProThrCysLeuSerSerLeuLeuGlvGlnLeuSerGIyGInVal ArgLeuLeuLeuGiyAiaLeuGinSerLjeuLeuGiyThirGinLeuProPrcGlnGlyArg ThrThrAlaHisLys SEQ ID NO：531 5 pMON23530

AlaAsnCysSerIleMetIleAspGluIleileHisHisLeuLysArgProProAlaPro LeuLeuAspProAsnAsnLeuAsnAspGluAspValSer I'leLeuMetAspArgAsnLeu ArgLeuProAsnLeuGiuSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly 10 IleGluAlalleLeuArgAsnLeuGlnPrcCysLeuProSerAlaThrAlaAlaProSer ArgHisProIleilelleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe Tyr Le uVa1Thr L e uG1uG1nA1aGInG1uG1nGInTyrVa1G1uG1yG1yG1yG1yS e r ProGiyGliiProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSer HisLysSer Pro AsriMet Alai iePheljeuSerPheGlnHisLeuLeuArgGlyLysVal 15 ArgPheLeuHetLeuVaiG.iyGlySerThrLeuCysValArgGluPheGlyAsnMetAla SerProAlaProProAlaCysAspLeuArgValLeuSerLysLeuLeuArgAspSerHis ValLeuHisSerArglteuSerGlnCysProGluValHisProLeuProThrProValLeu LeuProAlaValAspPheSerLeuGlyGluTrpLysThrGlnMetGluGluThrLysAla G1nAsp11e L euG1yA1aVaiThr LeuLeuLeuG1uG1yVaiMe tAi aA1aArgGlyG1n 20 LeuGlyProThrCysLeuSerSerLeuLeuGlyGlaLeuSerGIyGlnValArgLeuLeu LeuGlyAlaLeuGlnSerLeuLeuGlyThrGlnLeuProProGlnGlyArgThrThrAla HisLysAspProAsn SEQ ID NO:532 PMON28533 25

AlaAsnCysSeirlleMetlieAspGiullelleHisHisLeuIjysArgProProAlaPro LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerlieLeuMecAspArgAsnLeu ArgLeu?roAsnLeuGluSer?heValArgAlaVaiLysAsnLeuGluAsnAlaSerGly ^ IleGiuAlalieLeuArgAsnLeuGlnProCysLeuProSerAlaThrAiaAlaProSer 30 ArgHis?roIleIleIleLysAlaGiyAspTrpGinGlu?heArgGluLysIjeuThrPhe Ty r L euVa IT hr L e uG I uG 1 nA 1 aG I nG 1 uG 1 nG 1 nTy rVa 1G1 uG 1 yG I yG I yG 1 yS e r ProGLyGluProSerGlyProIleSerThrlleAsnProSerProProSerLysGluSer HisLvsSerProAsnMetGluValHisProLeuProThrProValLeuLeuProAlaVal ^ AspPheSerLeuGlyGluTrpLysThrGlnMeCGluGluThrLysAlaGlnAspIleLeu 35 GlyAlaValThrLeuLeuLeuGluGlyValMeCAlaAlaArgGlyGinLeuGlyProThr CysLeuSerSerLeuLeuGlyGlnLeuSerGlyGinValArgLeuLeuLsuGiyAlaLeu GlnSerLeuLeuGlyThrGlnLeuProProGlnGlyArgThrThrAlaHisLvsAspPro AsnAlallePheLeuSerPheGlnKisLeuLeuArgGlyLysValArgPheLeuMetLeu Va 1G1 y GI y S e rT hr L e u Cy s Va 1 Ar gG 1 u P h eG i y G1 y A s nG 1 y G1 y As e t A1 a S e r 40 ProAlaProProAlaCysAspLeuArgValLeuSerLysLeuLeuArgAspSerHisVal LeuHisSerArgLeuSerGinCvsPro SEQ ID NO：533 PMOM28534 45 AlaAsnCysSer I leMet I ieAspGiulle I leHisHisLieuLysAjrgProPrQAiaPro LeuIleuAspProAsnAsnLeuAsnAspGluAspValSer 工 leLeuMetAspArgAsriLeu ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly IleGluAlalleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer — Ar g H i s P r ο 11 e 11 e I i e L y s A1 aG 1 pT rpG 1 nG 1 u P h e Ar aG 1 u Ly s LeuT h r ? he 30 Ty rL e u Va IT h r L e uG i uG i rL^ I aG 1 nG 1 uG 1 nG 1 nTy rVa 1G1 uG I yG I yG 1 yG 1 y S e r

ProGlyGluProSerGl'/ProIleSerrThrlleAsnProSerProProSerL'/sGluSer HisLysSerProAsni-tetiLeuProThrProValLeuLeuProAlaValAspPheSerLeu GlyGluTrpLysThrGlnl^ecGluGluThrLysAlaGlnAspIleLeuGiyAlaValThr •和 Leu乙euLeuGluG丄yValMecAiaAiaArgGlyGlnLeuGLyProThrCyslieuSerSer 55 LeuLeuGlyGlnLeuSerGlyGlr*VaIArgLeuLeuLeuGlyAlaLeuGinSerLeuLeu G1yThrG1nLeu ? rc Pr oGInG i yArgThrThrΛ L aH i s Ly3 As p ? r oAs nA1a11e Phe LeuSerPheGlnHisLeuLeuArgGiyLysValArgPheLeuMetLeuVaiGiyGlySer T hr L euCy 3 -/a 1 Ar gG 1 u P heG i yG I y As nG 1 y GI y As nMe t: Λ1 a S e r P r 〇 A1 a P r ο P r o AlaCysAspLeuArgValLeuSerLysLeuLeuArgAspSerHisValLeu*4is5erArg 60 LeuSerGlnCysProGluValHisPro SEQ ID MO：534 PMON2 853 5 ...

AlaAsnCysSerIleMetIleAspGluIleileHisHisLeuLysArgProProAlaPro LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerIleLeuMetAspArgAsnLeu ArgLeuPrcAsnLeuGiuSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGIy IleGiuAialleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAiaProSer ArgKisPro IleI LeiieLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe TyrLeuValThrLeuGluGl^iaGlnGluGlnGlnTyrVaiGluGlyGlyGIyGlySer 70 ProGiyGIuProSerGlyPro ILaberThrIleAsnProSerProProSerLysGluSer HisLysSerProAsnMetiValLeuLeuProAlaValAspPheSerLeuGiyGluTrpLys ThrG inl-le cG luG luThr Lys AlaGlnAsp I leLeuGiyAlaValThrLeuLeuLeuGlu

LeuSerGIvGlnValArgLeuLeuLeuGlyAlaLeuGlnSerLeuLeuGlyThrGlnLeu 75 ProPrcGlnGlyArgThrThrAlaHisLysAspProAsrLAlallePheLeuSerPheGln -210-

O:\92\92747.DOC 200413407

HisLeuLeuArgGlyLysValArgPheLeuMecLeuValGlyGlySerThrLeuCysVal ArgGluPheGlyGlyAsnGlyGlyAsnMetAlaSerProAlaProProAlaCysAspLeu ArgValLeuSerLvsLeuLeuArgAspSerHisValLeuHisSerArgLeuSerGlnCys ProGluValHisProLeuProThrPro SEQ ID NO：535 5 PMCM23536

AlaAsnCysSerIieMetIleAspGIullelleHisHisLeuLysAjrgProProAlaPro LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerlleLeuMeCAspArgAsnLeu 10 ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly IieGiuAlalleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer ArgHisProIlel JLelleLysAlaGlyAspTrpGinGluPheArgGiuLysLeuThrPhe TyrLeuVaiThrLeuGluGinAlaGinGluGlnGlnTyrValGluGlyGIyGlyGlySer ProGlyGluProSerGlyProIieSerThrlleAsnProSerProProSerLysGluSer 15 KisLysSerProAsnMecAiaValAspPheSerLeuGlyGluTrpLysThrGlnMetGlu GluThrLysAlaGlnAspIleLeuGlyAlaValThrLeuLeuLeuGluGlyValMetAla AlaArgGlyGlnLeuGlyProThrCysLeuSerSerLeuLeuGiyGlnLeuSerGlyGIn ValArgLeuLeuLeuGlyAlaLeuGlnSerLeuLeuGlyThrGlnLeuProProGinGiy ArgThrThrAlaHisLysAspProAsnAlallePheLauSerPheGlnHisLeuLeuArg 20 GlyLysValArgPheLeuMetLeuValGlyGlySerThrLeuCvsValArgGluPheGly GlvAsnGIyGlyAsaMetAlaSerProAlaProProAlaCysAspLeuArgValLeuSer LysLeuLeuArgAspSerHisValLeuHisSerArgLeuSerGlnCysPrcGluVaiHis ProLeuProThrProValLeuLeuPro SEQ ID NO：536

25 pMOM23537

Ala-A.snCysSer I leHet I ieAspGiullelleH is His LeuLy sArgProProAlaP.ro LeuLeuAspProAsnAsnLeuAsnAspGluAspValSarlleLeuMetAspArgAsnCeu ArgLeuProAsnLeuGIuSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGiy 30 IleGluAialleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAiaAlaProSer ArgHisProIiellelleLysAiaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGiuGlyGIyGlyGlySer PrcGiyGluProSerGlyProIIeSerThrlleAsnProSerProProSerLysGluSer HisLysSerProAsnMetAspPheSerLeuGlyGluTrpLysThrGlni^etGluGluThr 35 LysAiaGlnAspIieLeuGlyAlaValThrLeuLeuLeuGiuGiyValMetAlaAlaiArg GlvGInLeuGlyProThrCysLeuSerSerLeuLeuGlyGlnLeuSerGIyGlnValArg LeuLeuLeuGlyAIaLeuGlnSerLeuLeuGlyThrGinLeuProProGInGlyArgThr ThrAlaHisLysAspProAsnAiallePheLeuSerPheGinHisLeuIjeuArgGlyLys ValArgPheLeuMetLeuValGIyGiySerThrLeuCysValArgGluPheGlyGlyAsn 40 GlvGlyAsnMetAlaSerProAlaProProAlaCysAspLeuArgValLeuSerLysLeu LeuArgAspSerHisValLeuHioSerArgLeuSerGlnCysProGluValHis ProLeu ProTxhr?roValLeuLeu?roAlaVal SEQ ID N〇：537 OM0N23538 45

AlaA.snCysSerIleMetlleAspGluIlelleHisHisLeuLysArgProProAlaPro LeuLeuAspProAsnAsnLeuAsnAspGluAspVaiSerlleLeuMetAspArgAsnLeu ArgLeuProAsnLeuGluSerPheVaiArgAlaVaiLysAsnLeuGluAsnAiaSerGly _ IleGluAlal leLeuArgAsnLeuGir'ProC'/sLeuProSerAiaThrAlaAlaPiroSer 50 ArgHisProIlellelleLvsAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe Tyr L euVa1ThrLeuG1uG i nA1aG1nG1uG1nGInTyr Va1G1uGIyG1yG1yG1yS e r ProGlyGlu?roSerGIy?roIIeSerThrIIeAsnProSerPro?roSerLysGluSer HisLysSer?roAsnl4ecGlyGiuTrpLysThrGlrLMecGluGluThrLysAiaGInAs9 11e L e uG1vA i a VaITh r Le u Le uL e uG1uG1yVa1Me cAi aA1aAr gGIyG1nL euG1y 55 ProThrCysLeuSerSerLeuLeuGlyGlnLeuSerGlyGInValArgLeuLeuLeuGly

AlaLeuGlnSerLeuLeuGLyThrGlnLeuProProGlnGlyArgThrThrAlaHisLys AspProAsnAlaIle?heLeuSerPheGlnHisLeuLeuArgGiyLysValArgPheLeu Me t L eu Va 1G1 y G1 y S e r‘Γ h r L e uC y s Va 1 Ar gG L u P h eG 1 y G1 ’：/A s nG 1 y G1 y A s nMe t AlaSerProAlaProProAlaCysAspLeuArgValLeuSerLysLeuLeuArgAspSer 60 HisVaiLeUxHisSerArgLeuSerGlnCysProGIuValHis ProLeuProThrProVal LeuLeuProAlaValAspPheSerLeu SEQ ID MO :538 ΌΜΟΝ23539 65 AlaAsnCysSerIieMetlleAspGluIlelleHisHisLeuLysArgProProAlaPro

LeuLeuAspProAsnAsnLeuAsnAspGl'dAspVa丄SerileLeuMetAspArgAsnLeu ArgLeuProAsnLeuGluSerPheValArgAiaValLysAsnLeuGluAsnAlaSerGIy IleGluAlalleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAiaAlaProSer ArgHisProIleilelieLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe 70 TyrLeuValThrLeuGluGlrLAiaGlnGluGlnGinTyrValGluGlyGiyGlyGlySer ProGlyGluProSerGlyProIleSerThrIieAsn?roSerProProSerLysGluSer HisLysSerProAsnMetGlyProThrCysLeuSerSerLeuLeuGlyGlnLeuSerGly G LnVa LArgLeuLeuLeuGl'/AlaLeuGinSerLeuLeuGlyThrGlnLeuPrQProGln _ GlyArgThrThrAlaHisLysAspProAsnAlallePheLeuSerPheGlnHisLeuLeu 75 ArgGlyLysValArgPheLeuMecLeuValGlyGlySerThrLeuCysValArgG LuPhe

O:\92\92747.DOC -211 - 200413407

GlyGlyAsnGlyGlyAsnMetAlaSerProAlaProProAlaCysAspLeuArgValLeu SerLysLeuLeuArgAspSerHisVaiLeuHisSerArgLeuSerGlnCyo ProGluVal HisProLeuProThrProVaiLeuLeuProAlaValAspPheSerLeuG LyGluTrpLys ThrGlni4etGluGluThrLysAlaGlnAspIleLeuGlyAlaVaIThrLeuLeuLeuGlu 5 GlyValMetAiaAlaArgGlyGlnLeu SEQ ID NO：539 pMON2 3 5 4 0

AlaAsnCysSerlieMetlleAspGiuIleileHisHisLeuLysArgProProAlaPro 10 LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerl leLeuMetAspArgAsnLeu ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsr^laSerGly IleGluAlal LeLeuArgAsnLeuGinProCysLeuProSerAlaTrhirAlaAlaPrQSer ArgHis ProIleileileLysAlaGl/AspTrpGinGluPheArgGiuLysLeuThrPhe TyrLeuVaiThrLeuGluGlrL\laGlnGluGlnGlnTyrValGiuGlyGlyGlyGlySer 15 ProGIyGluProSerGlyProIleSerThrlleAsnProSerProProSerLysGluSer HisLysSerProAsnMetGlyThrGlnLeuProProGlnGlyArgThrTiirAlaHisLys AspProAsnAiallePheLeuSerPheGlnHisLeuLeuArgGlyLysValArgPheLeu Me tLeuVa1G1yG iyS erThrLeuCysValArgG1u PheG1yGlyAs nG iyGlyAsnMe t AlaSerProAlaProProAlaCysAspLeuArgValLeuSerLysLeuLeuArgAspSer 20 HisVaiLeuHisSerArgLeuSerGlnCysProGluValHisProLeuPrcThrProVal LeuLeuProAlaValAspPhsSerLeuGlyGluTrpLysThrGloMeCGluGluThrLys AlaGlnAspIleLeuGlyAlaValThrLeuLeuLeuGluGlyValMetAlaAlaArgGiy GlnLeuGlyProThrCysLeuSerSerLeuLeuGlyGlnLeuSerGlyGlnValArgLeu LsuLeuGlvAlaLeuGlnSerLeuLeu SEQ ID MO :540 25 ^ ΌΜΟΝ28541

AlaA.snCysSer IleMet lieAspGIullelleiiisHisLeuLysArgProProAlaPiro LeuLeuAspProAsnAsnLeuAsnAspGluAspVaiSer IleLeuHetAspArgAsnLeu 30 ArgLeuProAsnLeuGluSerPheValArgAiaValLysAsnLeuGluAsnAlaSerGly IleGluAIalleLeuArgAsnLeuGlnProCysLeuProSerAiaThrAlaAiaProSer ArgHisProIlellelleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe Ty r L eu Va 1 Thr L· e uC-1 uGl oA 1 aG 1 nG 1 uG 1 nG 1 nTy r Va i G1 uG 1 yG 1 yG 1 yG 1 ySer ProGlyGluProSerGlyProIleSerThrlieAsnProSerPrcProSerLysGluSer 35 KisLysSer PrcAsnMecGlyArgThrThrAlaHisLysAspProAsnAlaliePheLeu SerPheGInHisLeuLeuArgGlyLysValArgPheLeuMecLeuValGlyGlySerThr LeuCysValArgGluPheGlyGlyAsnGlyGlyAsnMetAlaSerProAlaProProAla CysAspLeuArgValLeuSerLysLeuLeuArgAspSerHisVaiLeuHisSerArgLeu SerGlnCys ProGluValKis ProLeu?roThrProValLeuLeu?roAlaValAspPhe 40 SerLeuGlyGluTrpLysThrGlnMecGluGluThrLysAlaGlnAspXleLeuGlyAla ValThrLeuLeuLeuGluGlyValMecAlaAlaArgGlyGinLeuGlyProThrCysLeu SerSerLeuLeuGlyGlnLeuSerGlyGlnValArgLeuLeuLeuGlvAiaLeuGlnSer LeuLeuGlyThrGlnLeuProProGln SEQ 工D NO·, 541 45 pMON28542

AlaAsnCysSerlleMetlleAspGluIlelleHisHisLeuLysArgProProAiaPro LeuLeuAspProAsnAsnLeuAsnAspGiuAspVaiSerl leLeuMetAspArgAsnLeu _ ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGiuAsnAlaSerGlv 50 IieGluAlalleLeuArgAsnLeuGln^roCysLeuProSerAlaThrAlaAlaProSer'

ArgHisProlieIleileLysAlaGlvAspTrpGlnGluPheArgGiuLysLeuThrPhe TyrLeuValThrLeuGluGlnAlaGlnGluGInGlnTyrValGluGlyGlyGIyGlySer ProGLyGluProSerGlyProIleSerThrIleAsnPrcSerPrcProSerLysGluSer _ HisLysSerProAsriHetAlaHisL'/sAspProAsnAlallePheLeuSerPheGinHis 55 LeuLeuArgGlyLysValArgPheLeuMecLeuValGlyGlySerThrLeuCysValArg GluPheGiyG IvA.snGlyGlyAsmMe tAlaSer ProAlaProProAlaCysAspLeuArg ValLeuSerLysLeuLeuArgAspSerHisValLeuHisSerArgLeuSerGlnCysPro GluValHis ProLeuProThrProValLeuLeuProAlaValAspPheSerLeuGlyGlu TrpLysThrGlr,MetGluGluThrLysAlaGlnAspIleLeuGlyAiaValThrLeuLeu 60 LeuGluGlyVaiMetAlaAlaArgGlyGInLeuGlyProThrCysLeuSerSerLeuLeu

GlyGlnLeuSerGlyGlnValArgLeuLeuLeuGlyAlaLeuGlnSerLeuLeuGlyThr GlnLeuProProG丄nGlyArgThrThr SEQ ID NO：542

V ΌΜΟΝ23543 65

AlaAsnCysSer工leMetIieAspGiuIlelleHisHisLeuLysArgProProAlaPro LeuLeuAspProAsnAsnLeuAsnAspGluAspValSer I leLeuMetAspArgAsnLeu ArgLeuProAsaLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly I leGluAialIeLeuArgAsnLeuGln?roCysLeu?roSerAlaThrAlaAlaProSer 70 ArgHisPro rielleileLysAlaGlyAspTrpGlnGLuPheArgGluLysLeuThrPhe

TyrLeuValThrLeuGluGInAIaGlnGluGinGlnTyrValGluGlyGlyGiyGlySer ProGl'/GluProSerGiyProI leSerThr工 ieAsnPiroSej：?roProSeirLysGluSer HisLysSerProAsnMetAspProAsnAlallePheLeuSerPheGlnHisLeuLeuArg GlyLysVa lArgPheLeuMeCLeuValGlyGlySerThrLeuCysVa lArgGiuPheGly 75 -212-

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LysLeuLeuArgAspSerHisValLeuHisSerArgLeuSerGInCysProGLuVaiHis ProLeuProThrProValLeuLeuProAlaValAspPheSerLeuGlyGluTrpLysThr Glni^lecGluGluThrLysAlaGlnAspI leLeuGlyAlaValThrLeuLeuLeuGluGly ValMetAlaAlaArgGlyGlnLeuGlyProThrCysLeuSerSerLeuLeuGlyGlnLeu 5 SerGlyGlnValArgLeuLeuLeuGlyAlaLeuGlnSerLeuLeuGlyThrGlnLeuPro ProGlnGlyArgThrThrAlaHisLys SEQ ID NO：543 OM0N23544 10 AlaAsnC'/sSerIleMetlieAspGiuIleIleHisHisLeuL/sArgProProAla?ro LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerXleLeuMetAspArgAsnLeu ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGiuAsnAlaSerGI'/ IleGluJ\l<aI leLeuArgAsnLeuG 丄 nProCysLeuPiroSerAiaThirAliaAlaPiroSer· ArgHis?roI lellel leLysAlaGl'/AspTrpGlnGluPheArgGluLysLeuThr Phe I 5 TyrLeuVaiThrLeuG LuGlnAlaGinGluGinGiaTyrVaLGluGlyGlyGlyGlySer

ProGlyGluProSerGlyPro IleSerThrIleAsnProSerProProSerLysGluSer HisLysSerProAsniMecAlaIIe?hsLeuSerPheGinHisLeuLeu*^rgGiyL73Val A r g P h e L e u M e c L e u V a 1G1 y GI y S e r T h r L e u C y s V a 1A r g G1 u P h e G1 y GI y A s n G1 y GlyAsnMstAiaSerProAlaProProAlaCysAspLeuArgValLeuSerLysLeuLeu 20 ArgAspSerHisValLeuHisSerArgLeuSerGlaCysProGluValHisProLeuPro ThrPrcValLeuLeuProAiaValAspPheSerLeuGiyGiuTrpLysThrGinMecGlu GluThrLysAlaGlnAspIleLeuGlyAlaVaiThrLeuLeuLeuGluGlyVaiMecAia AlaArgGlyGlnLeuGiyProThrCysLeuSerSerLeuLeuGlyGInLeuSerGlyGln _ ValArgLeuLeuLeuGIyAlaLeuGlnSerLeuLeuGlvThrGlnLeu?ro?roGlnGiy 25 ArgThrThrAlaHisLysAspProAsn SEQ ID NO：544 ΌΜΟΜ28545 ^ AlaAsnCysSer工leMetlleAspGluIielleHisHisLeuLysArgProProAlaPro 30 LeuLeuAspProAsnAsnLeuAsnAspGluAspValSerileLeuMetAspArgAsnLeu

ArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSerGly 工 leGloAlal leljeuAirgAsnLeuGinProCysLeuPrQSerAiaThr'AlaAlaProSer· ArgHisProIlellelleLysAlaGlyAsp.TrpGinGluPheArgGluLysLeuThrPhe ^ TyrLeuValThrLeuGluGirLAlaGlnGluGinGlnTyrValGiuGlyGiyGlyGlySer 35 ProGlyGluProSerGlyProIleSerThrlieAsnPrcSerProProSerLysGluSer

HisLysSerProAsnMetAspProAsnAlaliePheLeuSerPheGinHisLeuLeuArg GlyLysValArgPheLeuMetLeuVaiGlyGlySerThrLeuCysValArgGiuPheGly GlyAsnMetAiaSerProAiaProProAlaCysAspLeuArgVaiLeuSerLysLeuLe'j ArgAspSerKisValLeuHisSerArgLeuSerGlnCysProGluValHisProLeuPro 40 ThrProValLeuLeuProAIaVdiAspPheSerLeuGlyGluTrpLysThrGlr^letGIu

GluThrLysA laGinAsp 工 ieLeuGlyAlaValThrLeuIjeuLeuGliiGlyValMetAla AlaArgGlyGlnLeuGlyProThrCysLeuSerSerLeuLauGlyGlnLeuSerGlyGin ValArgLeuLeuLeuGlyAiaLeuGinSerLeuLeuGiyThrGlnGlyArgThrThrAIa HisLys SEQ ID NO:545 45 PMON32132

_ Ser?roAlaiP::o?roAlaCysAspLe\_a\i:gVaiLeuSerLiysLeuLeuAr<5AspSerHis 50 Va 1L euH i s S er Ar g LeuS er GI p*Cy 5 P r oG 1 uVa IH i s ? r o L eu ? r οT hr ? r ο Va IL a u

Leu Pro A laVai Asp A丄 a G1 nA 3 p 11 e L e u G i y AI a V a 1T h r L e u L e u L e u GI u G i y V a i M e t: Λ1 a A1 a A r g G1 y G i a LeuGiyProThrCysLeuSerSerLeuLeuGlyGInLeuSerGlyGlnValArgLeuLeu _ LeuGiyAlaLeuGInSerLeuLeuGlyThrGlr.LeuProProGlnGIyArgThrThrAla 55 H i s L v 3 A 3 p ? r ο Λ 5 n A1 a 11 e ? h e L e u S e r ? h e G1 η H i 5 L e u L e u A r g G1 y L y s V a IΛ r g

PheLeuMecLeuValGlyGlySerThrLeuCysValArg SEQ ID MO :546 PMOM32133 60

SerProAlaProProAlaCysAspLeuArgValLeuSerLvsLeuLeuArgAspSerHis ValLeuHisSerArqLeuSerG inCys PrcGluVaiHis PrcLeuProT^rProValLeu LeuProAlaValAspPheSerLeuGiyGiuTrpLysThrGir^ietGluGluThrLysAla _ GlriAspIleLeuGIyAiaVaiThrLeuLeuLeuGluGlyValMetAiaAlaArgGlyGln 65 LeuGlyProThrCysLeuSerSerLeuLeuGlyGlnLeuSerGlyGInValArgLeuLeu LeuG 1 yAI aLeuG 1 nS e r LeuLeuG i yTh rGI nG I yAr gThrThr A1 aH i s Lys As p ?r o AsnAlai JLePheLeu;3ei:?heGlnHisLeuLeuArgGlyLysValArgPheLeuMet:Leu Va1G1yGiySerThrLeuCysVa1Arg SEQ ID MO：547 70 PMOM32134

SerProAlaProProAlaCysAspLeuArgVaILeuSerLysLeuLeuArgAspSerHis Va i LeuH i 3 Se rΛrg LeuSerG L r.C'/s ? roC 1 uVa i H i s ?ro Leu ?roTh r ProVa 1Leu 75 LeuPr〇AlaValAspPheSerLeuGiyGiuTrpLysThrGIr.Met:GiuGluThrLysAla O:\92\92747.DOC -213 - 200413407

GlrtAspI ieLeuGi vAlaValThrLeuLeuLeuGluGlyVaiMecAlaAlaArgGlyGln LeuGlyProThrCysLeuSsrSerLeuLeuGlyGInLeuSerGlyGlnValArgLeuLeu LeuGLy/XlaLeuGlnSerLeuLeuGlyThrGlnLeuProProGlnGlyArgThrThrAla ^ HisLysAspProAsnAial lePheLeuSer PheGlnxHisLeuLeuArgGlyLysValArg 5 PheLeuMetLeuValGiyGlySerThrLeuCysVaiArg SEQ ID NO：548 pMON3 02 3 7. pep

AlaThrGloAspCysSerPheGInHisSerPro XleSerSerAspPheAlaValLys He 10 ArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGln AspGiuGIuLeuCysGlyAlaLeuTrpArgLeuValLeuAiaGlnArgTrpMetGluArg LeuLysThrValAlaGlySerLysMetGlp.GlyLeuLeuGLuArgValAsn'ThrGluIle H i s P h eVai Th r Lys Cy s A1a ? heG1η P r ο P r ο P ro S e rCys L e uArg P heVaIG i nThr AsnlleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAIaLeuLysProTrpIIe 15 ThrArgGloAsriPheSerArgCysLeuGluLeuGinC’/sGlnPro SEQ ID NO :549 pMON3 02 3 3. pep

20 AlaThrGlrLAspCysSerPheGlnHisSerProIIeSerSerAspPheAlaValLysIle ArgGluLeuSerAspTyrLeuLeuGinAspTyrProValThrValAlaSerAsnLeuGin AspGluGluLeuCysGlyGlyLeuTrpArgLeuVaILeuAlaGlpJ\rgTrpMetGluArg LeuLysThrVaiAiaGlySerLysMetGInGlyLeuLeuGluArgValAsnThrGluIle _ HisPhe'/alThrLysCysAlaPheGInPrcProProSerCysLeuArgPheValGInThr 25 AsnlleSerArgLeuLeuGlnGluThrSerGiuGlnLeuValAlaLeuLys ProTrpIle ThrArgGlnAsnPheSerArgCysLeuGIuLeuGInCvsGInProAspSerSerThrLeu SEQ ID MO :5 50 " ‘ pMON30239.ceo 30 '

AlaThrGInAscCysSerPheGInHisSerProIieSerSerAspPheAlavalLyslie ArgGluLeuSerAspTyrLeuLeuGinAspTyrProValThrVaiAlaSerAsnLeuGln AspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArg ♦ LeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIle 35 KisPheVaiThrLysCysAlaPheGlnGluThrSerGIuGlnLeuValAlaLeuLysPro TrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSer ThrLeu SEQ ID NO：551 40 OM0N32329.pep

GlyThrG LoAspCysSerPheGInHisSer?roIIeSerSerAspPheAlaValLyslie ArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrVaiAlaSerAsnLeuGln _ AspGiuGIuLeuCysGiyGiyLeuTrpArgLeuValLeuAlaGlnArgTrpMecGluArg 45 LeuLysThrValAiaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIIe His?heValThrLysCysAlaPheGlr.?roProProSerCysLeuArgPheVaiGlr.Thr AsnlleSerArgLeuLeuGlnGLuThrSerGluGlnLeuValAlaLeuLysProTrpIle ThrArgGlnAsnPheSerArgC'/sLeuGluLeuGInCysGlnPro SEQ ID NO :552 * 、 50 pMON3 2 3 30. cep < G1 yTh rG 1 nAs pC ys S e r ?heG InHisSerPrroIleSerSe r As p ?he A1 a'/a 丄 Ly s 工 1 e ArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGln 55 AspG i uGIu Le uCysGlyG1yL euT rpAr g LeuVa1LeuAIaGloArgTrpMe cGluArg

LeuLysThrValAiaG LySerLysMe tGInGlyLeuLeuG iuArgVa1AsnThrGlulie x4is PheValThrLysCysAIaPheGlnProProProSerCysLeuArgPheVaiGlr.Thr AsnlieSerArgLeuLeuGInGluThrSerGluGInLeuV’aiAiaLeuLys ?roTrpIie ThrArgG lrL.\sn?he5erArgCysLeuGiuLeuG InC^/sGlnProAspSerSerThrLeu 60 SEQ ID NO：553 pMOM32 34i. pep

ArgGiuLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGln AspGluGluLeuC73〇I'/GiyLeuTrpArgLeuValLeuAiaGlnArgTrpMet:GluArg LeuLysThrVa LAiaG 1 ySerLysMecG InG Ly LeuLeuG IuArgVa 1 AsnThrG I u lie

HisPheVaiThrLy3CysAla?heGln?roPro?roSerCysLeuArgPheVaLGlnThr 70 AsαI ieSerAr ：rLeuLeuG 1 r,G iuThrSerGluGInLeuVa lAlaLeuLys ProTrpI le T h r A r 7 G L r Λ s n ? h e S e r Λ r g C y 3 L e u G i u L e u C i a C y s G i n ? r o SEQ ID iiO :554 ^ _ pMOM3 2 3-i： . pep

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AlaThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaVa iLyslie ArgGluLeLLSeirAspTyrLeuLeuGlnAspTyirPrroValThr'/alAlaSerrAsnLeuGin AspGluGluLeuC'/sGlyGiyLeuTrpAr'gLeuValLeuAlaGlnArgTrpMetGiuArg _ LeuLys’ThrVaiAiaGl'/SeirLysMetGlnGl/LeuLeuGluArgValAsnThrGluIle 5 HisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGiaThr Asnl j_e

ThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeu SEQ ID NO:555 ^ 10 CMOM3 2 3 2 0. pep

AlaAspGiuGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGlu _ ArgLeuLysThrValAlaGiySerLysMetGlnGlyLeuLeuGluArgValAsnThrGlu 15 IleHisPheValThrLysCvsAlaPheGlnProProProSerCysLeuArgPheValGln ThrAsnl leSerArgLeuLeuGlnGluThrSerG JLuGinLeuValAlaLeuLys ProTrp IleThrArgGinAsnPheSerArgCysLeuGluLeuGlnCysGInProAspSerSerThr Leu S e rG i yG1yAs nG1yS erG1yGlyAs nG1yS e rG1yG1yAs nG1yThrG1nAs pCys SerPheGlnHisSerProIleSerSerAspPheAlaVaiLys 工 ieArgGiuLeuSerAsp 20 TyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGln SEQ ID MO :556' PMON32321.pep 25 AlaAspGluGiuLeuCysGlyGlyLeuTrpArgLeuValLeaAiaGirLArgTrpMetGlu

ArgLeuLysThrValAiaGlySerLysMetGlnGlyLeuLeuGluArgVaiAsnThrGiu I leHis pfieVa lThrLysCysAlaPheG.-inPro Pro ?r oSerCys LeuArg PheVa 1_G 1 n ThrAsnlleSerArgLeuLeuGlnGluThrSerGluGinLeuVaiAiaLeuLysProTirp ^ IleThrArgGIrJ\snPheSerArgCysLeuGluLeuGinCysGln?roAspSerSerThr 30 Leu S e rG1yGIyAs nG1yS erG1yGlyAs nG1yThrG1nAs pCysSerPheGlnHisSer

ProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlrJXsp TyrProValThrValAlaSerAsnLeuGIn SEQ ID NO：557 35 pMOM32322.pep

AlaAspGiuGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGlui ArgLeuLysThrValAiaGiySerLvsiyLecGlnGlyLeuLeuGluArgVaiAsnThrGlu IleHispfie'/alThrLysCysAiapfieGlnProProProSerCysLeuArgPheValGln 40 ThrAsnlleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrp lieThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThr LeuSerGlyGIyAsnGlyThrGInAspCysSerPheGlnHisSerProllsSerSerAsp PheAlaV’alLys IleArgGluIjeiiSerAspTYrLeiiLeuG丄nAspTyrProVal.ThrVal AlaSerAsnLeuGln SEQ ID MO： 558*" ^ 45 pMQN32323.pep A1 a S e r Ly s Me t GI nG i y L e uL e uG i uAr g Va 1 As nT h r GI u 11 eH i 3 P h e ν' a i T xh r Ly s 50 CysAlaPheGinProProProSerC’/sLeuArgPhe'/aiGLnT'hrAsrLi leSerArgLeu L euG 1 nG i uThr S e r GI uG 1 r.LeuVa 1A1 aLeuLy s P r oT r p I i eT hr Ar gG I r^.s η P he S e r Ar gC y s L e uG I li LeuG I nCysG I η P ro As p S e r S e rT hr L eu S erG1 yG I yAs r*G I y S e r G1 y G i y As nG 1 y S e r G1 y G1 y A.s nG I y T h r G1 nA3 pC y 3 S e r Ph eG1 nH i 5 S e r P r o I leSerSerAspPheAlaVaLLys 55 ProValThrVaiAlaSerAsnLeuGlnAscGluGluLeuCysGiyGlylieuTrpArgLeu VaILeuAIaGIr^ArgTrpMecG 1 uArgLeuLysThrVa 1AiaG 1 y SEQ ID MO :559 PMOM32324.pep 60

AlaSerLysMecGlnGlyLeuLeuGluArgValAsnThrGluIleHis PheValThrLys CysAla?heGlnProProProSerCysLeuArg?he'/alGlnThrAsnIle3erArgLeu LeuG 1 nG 1 uT h r S e r G1 uG 1 n L eu Va 1A1 a L eu Ly s ? r oT r p 11 eT h r Ar gG I nAs η P h 0 SerArgCysLeuGIuLeuGlnCysGlnProAspSerSerThrLeuSerGlyGlyAsnGiy 65 SerGiyGlyAsnGlyThrGlrLAspCysSerPheGlnHisSerProILeSerSerAspPhe A1 a V a i L y 311 e A r g GI u L e u S e r A s p T y r L e u L e u GI π A 3 p T y r P r ο V a IT h r V a IA1 a Se r As nLeuG 1 nAspG LuG luLeuCysG 1 yG ly LeuTrpAr gLeuVa 1 LeuA 1 aG 1 nArg TrpMecGluArgLeuLvsThrValAlaGiy SEQ ID MO：560 70 〇MON3 2 3 2 5. pep

AlaSerLysMetiG InGlyLeuLeuG luArgVaiAsnThrG iul leHis PheValThrLys C y s A1. ri P h e η P r ◦ P:: o P:: o S e r C y s L e u A r* g P h e V a i G L rr Γ h:: A s nrieSerAr.gLeu 75 LeuGLnGiu.rhrSerGLuGinLeuValAiaLeuLysProTrpUeThrAirqGinAsnPhe -215 -

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S e r Air gC γ s LeuG i u LeuG i nCy sG 1 η P iro As p S e r S e rTh r LeuS e rG 1 yG l y As nG 1 y ThrGlrJXspCysSerPheGir.HiGSerPro I ieSerSerAspPheAlaValLys I leArg GluLeuSerAspTyrLeuLeuGlaAspTyrProValThrValAiaSerAsaLeuGlnAsp G L uG 1 u L e uC y s C· i y G1 y L e uT r p A r g L e u Va i L e u A1 aG 1 rJvr gT r p ϊΊβ CG1 u Ar g L e u LysThrValAiaGly SEQ ID NO :56 I OMCN32326.pap 10 Ala?roProSerCysL,euArgPheVaIG ir/ThrAsnl leSerArgLeuLeuGlnGIuThr SerGluGInLeuValAlaLeuLys ProTrpIieThrArgGlaAsnPheSerArgCysLeu G1uLeuG i nCysG1η P ro As p S e r S e rTh r Leu S e rG1yG1yAs nG1y S e rGlyG i yAs n GlySerGlyGlyAsnGlyThrGlpLAspCysSer PheGlnHisSer Pro I leSerSerAsp ? heA1aVa1Lys11eAr gG1uL e u S e rAs pTy r L euLeuG1nAs pTyr ? r o Va1T h rVa1 1 5 AlaSerAsnLeuGlr^spGiuGluLeuCysGlyGiyLeuTrpArgLeuValLeuAlaGln

ArgTrpMetGluArgLeuLysThrVaiAiaGlySerLysMe cGlnGlyLeuLeuGluArg Va1ΛsπThrG1u11eHis?heVa1ThrLysCysAia?heG1η?ro SEQ ID NO：562 20 pMOM32327.pep

Ala?roProSerCysLeuArg?heValGlnThrAsnIIeSerArgLeuLeuGlnGluThr SerGluGlnLeuValAlaLeuLvsProTrpI leThrArgGlnJ^.snPheSerArgCysLeu ^ GluLeuGlnCysGlnProAspSerSerThrLeuSerGlyGlyAsnGlySerGlyGlyAsn 25 GlyThrGInAspCysSerPheGlaHisSerProIleSerSerAspPheAlaValLysIIe ArgGiuLeuSerAspTyrLeuLeuGln^.spTyrProValThrValAlaSerAsnLeuGln AspGIuGluLeuCysG1yGlyLeuTrpArgLeuVa1LeuAIaG inArgTrpMe tG1uArg LeuLvsThrVa1A1aGlyS e rLysMe tGInG LyLeuLeuG i uArgVa1As nThrG1uIle His?heValThrLvsCysAla?heGIn?ro SEQ ID MO :563 30 pMOM323 23. pep ^ AlaProProSsrCysLeuArgPheValGlnThrAsnlleSerArgLeuLeuGlnGluThr 35 SerGluGlnLeuValAlaLeuLys ProTrpIieThrArgGlrLA.snPheSerArgCvsLeu G1 uL euG I nCy 5G1 n ?r o As p S er S e rThr Leu S erG1 yG 1 y As nG 1 yTh rG i nAs pCy s Ser?heGlnHisSerProIieSerSerAsp?he；\laVaiLy;IleAr&GluLeuSerAsp TyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGLuLeuCys G1 y G i y L e uT r p Ar g L e u Va 1L e u A1 aG 1 aAr gT r p Me cG 1 u A r g L e u Ly s T h r V a 1A1 a 40 GlySQrLys M91GI nG 1V L Le uG 1 u Ar α V a 1 As nT hr 51 u ί 1 e Η i s ? h e '/a 1T h r L y s

CysAlaPheGInPro S£Q ID NO：564^ pMCN323 43. pep 45

AlaAspGiuGiuLeuCysGlyGIyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGiu ArgLeuLysThrVaiAlaGlySerLysMetGlnGlyLeuLeuGluArgVaiAsnThrGlu IleHis PheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGln _ ThrAsnlleSerArgLeuLeuGlnGIuThrSerGluGlnLeuValAlaLeuLysProTrp 50 lieThrArgGin^.snPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThr LeuSerG 丄 5 e r ? heG Ir.HisSerProIleSerSe r Asp P he A i a Va I Ly s I i e Ar gG 1 uLeu 5 e r As p TyrLeuLeuGinAspTyrProValThrVaiAlaSerAsnLeuGin SEQ ID NO：565 "- cMCM3 2 3 5 0. pep A1 aAs pG 丄 uG i u LeuCy sG L yG i y LeuT r p Ar ς Le u'/a i Le uA1 aG 1 nAr gT rpMe CG 1 u ArgLeuLysThrValAiaGiySerLysMecGlnGiyLeuLeuGluArgVaiAsnThrGlu 60 IleHis PheVaiThrLysCysAlaPheGlaProProProSerCysLeuArgPheValGin. ThrAsnl ieSer

IleThrArgGipJ^sriPheSeirArgCysLeuGLuLeuGlaCysGlnPrcA^pSerSerThr LeuSerGiyGlySerGlySerGlyGlySerGlyThrGlnAspC^/sSerPheGinHisSer ProIIeSerSerAspPheAlaValLysIleArgG LuLeuSerAspTyrLeuLeuGlnAsp 65 TyrProValThrValAlaSerAsnLeuGin SEQ ID MO：56〇' FLT3M.pep 70 Me t: A i a: h r GI nAs pC ys S e r ? heG i nH i s S e r ? rc 11 e 5 e r S e r As p ? h e AI a V a 1 Lys I leArgG ：uLeuSerAspTvrLeuLeuG：r.AspTyr?roValThrValAlaSer:AsaLeu GlnAspGluGluLeuCysGiyGIyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGlu A r g L e u L y 3 T h r V a 1Λ i a G1 y S e r L y s M e c G1 n G1 y L e u L e u G1 u A r g V a 1Λ s n T h r G1 u y IieHL3?heVaLThrLy3Cy3Ala?heGlrL?ro?roProSerCysLeuArgPheValGln / 5 ThrAsnI-^SerArgLeuLeuGlnGiuThrSerGluGlnLeuValAlaLeuLys ProTrp -216-

O:\92\92747.DOC 200413407 ILeThrArgGinAsnPheSerArgCys LeuGluLeuGinCysGlnProAspSerSerThr LeuGlyGlyGlySer SEQ ID NO :567 5 F乙T3C.pep

GlvSerGlvGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAla VaiLysIleArgGluLeuSerAspTyrLeuLeuGirLAspTyrPjroValThrVaLA 丄 aSer AsnLeuGlnAspGiaGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrp 10 Me tG i uAr g L e uLy s .Th r Va 丄 A1 aG 1 y S e r Ly sMe tG 1 nG 1 y L euLeuG 1 u Ar g Va 1 As n

ThrGluIleHis PheValThrLysCysAiaPheGlnProProProSerCysLeuArgPhe ValGlnThrAsnlLeSerArgLeuLeuGlnGluThrSerG LuGlnLeu'/alAlaLeuLys ProTrpI丄eThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSer SerThrLeu SEQ ID MO:568 15 FLT7N.pep

MetAlaThrGlnAspCysSejrPheGlnHisSerProIleSerSerAspPheAlaValljys 20 IleArgGIuLeuSerAspTyrLeuLeuGlaAspTyrProValThrValAIaSerAsnLeu GlrJ^spGluGIuLeuCysGiyGlyLeuTrpArgLeuVaiLeuAlaGlnArgTrpMecGIu ArgLeuLysThrValAlaGIySerLysMetGlnGiyLeuLeuGluArgValAsnThrGlu IleHisPheValThrLysCysAlaPheGlnProProProSerCysLeiL^rgPheVaiGin ThrAsnlieSerArgLeuLsuGlnGiuThrSerGluGlnLeuValAlaLeuLysProTrp 25 ILeThrArgGinAsnPheSerArgCysLeuGluLeuGinCysGlnProAspSerSerThr

LeuGlyGlyGlySerGiyGiyGlySer SEQ ID NO:569 FLT4C.ceo 30 ' G1ySerG iyGIyG1yThrG1nAspCys Sar PheG i nH is S er Prο 11eSer SerAs p ?he AlaValLysIleArgGluLieuSerAspTyrLeuLeuGlnAspTyrProValThrVaiAla S erAs nL euGInAs pGIuGIuL euCysGIyG1yLeuT rpArgLeuVaIL e uAlaG i nAr g ^ TrpMetGiuArgLeuLysThrValAlaGiySerLysMetGlnGlyLeuLeuGLuArgVal 35 AsnThrGiuIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeuArg

PheValGlnThrAsnlleSerArgLeuLeuGinGluThrSerGluGlnLeuValAlaLeu LysProTrpI J_eThrArgGioAsnPheSerArgC：/sLeuGluLeuGlnCysGlnProAsO SerSerThrLeu S£Q ID NO：570 ' 40 FLTllN.pep

Me t: A i aT h rGl nAs p C y s S e r P h eG 1 nH i s S e r ? r ο IL e S e r S e r As p ? he A1 a V，a 1L i/ s _ 工leArgGiuLeuSerAspTyrLeuLeuGliiAspTyrPrnValThrVaLAlaSerAsnLeu

45 GlnAsOGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGlu ArgLeuLysThrValAlaGlySerLysMetGInGlyLeuLeuGluArgVaiAsn'ThrGiu I leHis?he'/aiThrLysCysAlaiPheGln?ro?rc)ProSerCysLeuArgPhe'/aiGln ThrAsnl leSerArgLeuLeuGinGIuThrSerGluGlnLeuValAlaLeuLysProTrp _ IleThrArgGIr^snPheSerArgCysl.euGluLeuGinCysGlnProAspSerSerThr 50 LeuGiyGiyGiySerGlyGlyGlySerGlyGlyGlySer SEQ ID MC：571 FLTlOC.pep 55 GlySerGlyGIyGi/SerGlyGlyGIySerGlyThrGlnAspCysSerPheGlnHisSer ProIieSerSe rAs p PheAi aVai LysIi eArgGIuLeuS erAspTyrLeuLeuG i nAso

LeuValLe uA i aG L aA r gT r p Me t GI u Ar g L e u Ly s T h r Va 1AI aG 1 y S e r Ly s Me t Q i n G1 y L e u L e uG 1 u A r g Va 1 As nT h r G1 u 工 1 e H i s ? fi e Va 1 丁 h r Ly s C y s A1 a ? h eG 1 η P r o 60 ProProSerCysLeuArgPheValGlnThrAsnXleSerArgLeuLeuGinGiuThrSer G LuG LnLeu'-’alAlaLeuLysPrcTrpIleThrArgGlnAsnPheSerArgCysLeuGiu LeuGInCysGinPrcAspSerSerThrLeu SEQ ID NO :572 、 65 OM0M3235S.pep A1 a As pG IjjG ί u L e uC y s G1 y G i，/ L euT r p Ar g L eu'/a 1 Leu A1 aG 1 nA r gT r pMe tG 1 u ArgLeuLysThrValAlaGiySerLysKetGlaGlyLeuLeuGluArgValAsnThrGIu I ieHis PheVa lThrLysCysAla?heGlr.?ro ProProSerCysLeuArgPheVa iGln 70 ThrΛ3η IL eS e r A rg Leu LeuGI nG IuTh；r Se rGIuG1 nLeuVa 1A1 a LeuLy 3 Pr οTrp I leThrArgGlnAonPheSerArciCysLeuGluLeuGinCysGlnProAspSerSerThr LeuG L./C； i:/'J ]_'/SerG 丄 yG iyThrG InAspCysSer PheGlnHisSerPro IleSerSer AspPheAi jiVa iLysIleArgGluLeuSerAspTyrLeuLeuGlnAsDTyrProVaiThr • VdlAldSeirAsnLeuGin SEQ ID Ν〇··573' ' O:\92\92747.DOC 217- 200413407 〇MON3：366.pep • AlaAspGluGluLeuCysGlyGiyLeuTripArgLeuVallLeuAiaGlnArrg'rrpMetGiii 5 ArgLeuLysThrValAlaGlySerLvsMetGlaGlyLeuLeuGluArgValAsnThrGlu IleHisPheVaiThrLysCysAiaPheGlnProProProSerCysLeuArgPheVaiGln Τ4;τΑ：3ηηθ5θ：ΓΑ::.3[^€ϊΐιΐ6，」〇ΐΓ·〇1ιιΤΐΐΓ5θ]：Ο1ιιΟ1η：1-Ξα'Λ^ΐΑΐα1：0υί/:/：3Ρ::〇τι:ρ

IleThrArgGlnAsaPheSerArgCysLeuGluLeuGlnCysGinProAspSerSerThr LeuGlyGlyGlySerGlyGlyGlyThrGlnAspCysSerPheGlnHisSerProIieSer 10 S e r As p P h e A i a Va 1L y s 工 1 e Ar gG i u L e u S e r A s p.Ty r L >e u L e uG 1 nA s pTy r ? r 〇 Va 丄

ThrVaiAlaSerAsaLeuGln SEQ ID MO：574^ ' ^ DMOM32357.cep 15 ' *

AlaAspGIuGiuLeuCysGIyGlyLsuTrpArgLeuValLeuAiaGlr^.rgTrcMetGlu Ar g L e uL y s T h r Va i A1 aG 1 y S e r Ly s Me tG I nG 1 y Le uLeuG I u Ar g Va I As aT hr GI u IleHio PheValThrLysCysAlaPheGInProProProSerCysLeuArgPheValGln ThrAsnl leSerArgLeuLeuGlnGIuThrSerGluGlnLeuVaiAiaLeuL^/s ProTrp 20 I leThrArgGIrL^saPheSerArgCysLeuGluLeuGir.CysGlnProAspSerSerThr LeuG 1 yG 1 yG 1 y Ser G1 yG I yG 1 y SerG i yG 1 yThrG i r^spCy s S e r Ph eG I nH i s S er Pro IieSerSerAspPheAlaValLys 工 ieArgGluLeuSerAspTyrLeuLeuGinAsp TyrProvaiThrValAlaSerAsnLeuGln SEQ ID ^0:575^ ^

25 PMOM32363.pep

AlaAspG iuGluLeuCysGlyGlyLeuTrpArgLeuVa iLeuAlaG ir^.rgTrpMe cGlu Ar g Leu Ly sT hr Va I aI aG 1 y S e r Ly s Me tGI TiG 1 y LeuL euC* i uAr g Va ί As γ/Γ hr G1 u 30 IleHis PheVaiThrLysCysAIaPheGlnProProProSerCysLeuArgPheValGln ThrAsnl leSer ArgLeuLeuGlnGiuThrSerGluGlnUjeuValAlaLeuL'/s ProTrp 工leThrArgGinAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSeriSerThr LeuG I yG 1 yG i y S erG 1 yG 1 vG i y S e rG i yG I vG 1 y S er GI yThrG i rJ\s pCy s S e r Phe • GlnHisSerProIIeSerSerAspPheAiaValLysIleArgGluLeuSerAspTyrLeu 35 LeuG1nAspTyr ?roVaIThrVaIA1aSerAsnLeuGin SEQ ID MO :57 6 pMON3 2 3 6 9 pep 40 AlaAspGluGluLeuCysGiyGLyLeuTrpArgLeuVaiLeuAiaGlnArglTrpMetiGlu ArgLeuLysThrVa1Ai aGlySe rLysMe tGInG1yLeuLeuG1uArgVa iAs nThrGlu 11 e H i s P h e V a 1T h r L y s C y s A1 a ? h e G1 n ? r ο P r ο P r o S e r C y s L e u A r g ? h e V a IG i n ThrAsnlleSerArgLeuLeuGinGluThrSerGluGlnLeuVaiAlaLeuLys Pro.Trp IleThrArgGlnAsaPheSerArgCysLeuGluLeuGinCysGIaProAspSerSerThr 45 LeuGiyGIyGlySerGlyGlyGlySerGlyGiyGlYSerGiyGlyGlyThrGlnAspCys SerPheGinHisSerProIleSerSerAspPheAlaVaiLysIieArgGluLeuSerAsp TyrLeuLeuGinAsOTyrProVaiThrValAlaSerAsaLeuGln SEQ ID >】〇：577

50 pMON32 270. pep A1 a A s p G1 u G1 u L e u C y s G i y G1 y L e u T r p A r g L e u V a IL e u A i a G1 nA r g Ί' r p ί Ί e ϋ G i'j A r g L e u L v ^ s T h r V a IΛI a G1 y S e r L V s M e t GI n G1 y L e u L e u G1 u A r g V a 1A s r. T h r G1 u IleHis PheVa LThrLysCysAlaPheGIn?roProProSerCysLeuArgPheVaiGIn 55 ThrAsnlieSerArgLeuLeuGInGluThrSerGiuGlnLeuValAlaLeuLysProTrp 11 e T h r A r g GI s n ? h e S e r A r g C y s L e u G i u L e u GI n C 7 s G1 n ? r c A 3 p S e r S e r T h r LeuGiyGiyGlySerGIyGlyGlySerGlyGiyGIySerGiyGiyGlySerGlyGlyGly S e r G i y ‘T r· G1 nA s p C y s S e r ? h e G i η H i s S e r P r 〇工 i e S e:: S e:: A s p ? h e A. i a V a i L y s I L e Ar gG L u L e u S e r As p.Ty r L e u L e uG 1 nA s p T，/ r P r ο Va i Th r Va ]_ A i a S e r As nL e u 60 Gin SEQ ：D NO：573' " pMOM3 0247. pep 、

AlaAsnC’/sSei: I ieMec工 leAspGiuI lei ieHisHisLeuLysArgPiroProAlaPro 65 LeuLeuAspProAsriAsnLeuAsr^spGluAspVa LSer I leLeuMeCAspArgAsnLeu r g L e u P r o A s n L e u G1 u S r P h e V. a i A r g A1 sV a i 1// s A s n L έ u G1 u A s n^. 1 d S e r G1 neGiuAidlieLeuArgAsnLeuGlnPrcCysLeuPiroSerAiaThirAiaAlaProSer ArgHis?「oUe: leUeLysAidGl'/AspTrpGLnGliiPheAirgGiuLysLeuThrPhe TyrLeuVa IThrLeuGluGiruAiaG LnGluGlnGlr.TyrVaiGlaGlyGiyGiyGlySer 70 PrcGlyGluProSerGlyPrcIieSerThrliaA^nProSarPro?rc3erLysGluSer H i3Ly3Se r ProAsnMetAlaThrGInAspCysSer PheGlnHisSer ProlleSerSer

ValAlaSerAsr.LeuGInAspG LuGluLeuCvsGlyAiaLeuTrpArgLeuValLeuAla GlaAraTrcMecGluArgLeuLysThrVaIAlaGlySerLysMecGlnGiyLeuLeuGiu 75 Arg'/aiAjrvrhrGluIieHispfie'/dlThrLysCysAlaPheGlnProProProSerCys

O:\92\92747.DOC -218- 200413407 L e u A r g P K e V a i G1 η T h r A s η ： L e S e r Λ r g L e u L e u G 1 n G1 u T h r S e r G1 u G1 a L e u V a 1 A a L e u L· y c; P r ο T p I e T h r A r g G L n A s n ? h e S e r A r g C v s L e u G 丄丨a L e u G L n C y s G L n Pro 5EQ ID NO：579 ^ 5 CWOM3 02 43. pep A.laAs nCy s Ser 11 eMe til eAspG lu 11 e 11 eH i s H i s LeuLy s Arg Pro ? r o Ala Pro LeuLeuAspProAsnAsnLeuAsnAspGiuAspVaiSerIleLeuMecAspArgAsnLeu 10 Ar g L e u P r o As nL e uG I u S e r ? he Va I Ar g AI aVa i L y s As n L e uG 1 uAs n.-. I a 3 e rG 1 y

IlsGluAlal leLeuArgAsr.LeuGlnProCysLeuProSerAlaThrAlaAiaProSer Ar gH i s ? r ο 11 e 11 e 11 eLy s A LaG i yAs pTrpG 1 nG 1 u PheAr gG I uLy s LeuT h r ?he TyrLeuValThrLeuGiuGlnAlaGlriGiuGiaGlnTyrValGluGlyGlyGlyGlySer _ ?roGLyGlu?roSerGiyPro IieSerThrI丄eAsnProSerProProSerLysGluSer 15 H i s Ly s 3 e r ? r oAs ΓαΊθ t AI aT h rG I pCy s S e r P heG 1 nH i s S e r P r ο 11 e S e r S e r

AsppfieAlaV’aiLys I Pro'/alThr V a 1A1 a S e r A s n L e u G i πΛ s p G i，」G1 u L e u C y s G1 y A1 a L e u ? r p A r g Ij e1 j V a i L e u A1 a G1 nA r g T r p M e c G i u A r g L e u L y s T h r V a 1A1 a GI y S e r L y s M e t GI n GI y L e u L e u G1 u ArgValAsnThrGluIleHis PheValThrLysCysAlaPheGlnProProProSerCys 20 LeuArgPheValGlnThrAsnlleSerArgLeuLeuGInGiuThrSerGiuGinLeuVal AlaLeuLys ProTrpIleThrArgGlnAsnPheSerArgCysLeuGiuLaaGinCysGIn ProAspSerSerThrLeu SEQ ID MO :5 30

25 CMON32332.pep A1aAs nCys S e r11eMe 11i eAs pG1u11s11eH i s H i s LeuLys Ar g ? r o ? r o A1a ? ro Leu LeuAs p ? r c· As nAs nL euAs nAspG 1 uAs p Vra 丄 S e r 11 euMe t As p ArgAs nLeu Ar g L e u P r c A 5 n L e uG 1 u S e r ? h e Va I Ar g AI a Va 1L y s As n L e uG I u A s n.\ I a S er G1 y 30 Z]_eGluAldeLeuArgAsnLeuGin?roCysLeu?roSerAlaThrAlaA；L.dProSer ArgHisProIiellellsLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe T y r L eu Va 1T h r L euG 1 uG i I aG I nG i uG I nG I nTy r Va i GI uG I y GI y GI y G1 y S e r ProGiyGluProSerGlyProIleSerThrlleAsnProSerProProSerLysGiuSer 一 HisLysSerPrcAsnMetAlaAspGiuGluLeuCysGlyGlyLeuTrpArgLeuValLeu 35 A1 aG 1 r.Ar gT rp Me cG1 r g L e u Ly s T h r Va 1A i aG Iy S e r Ly s Me t GI nG 1 ·/ L e u L eu

GluArgValAsnThrGlu·工 ieHisP^ieValThrLi/sCysAlapfieGlnProProPiroSer CysLeuAr gPheVaiGlnThrAsnl leSerArgLeuLeuGlnGlu.ThrSerGluGlrLLeu Va 1AI aL eu Ly s P r oT rp I i eT hr Ar gG I nAsη P he 5 ar Ar gCy s LeuG I u L euG i nCy s G1 η P r o A s p S e r S e rT h r L e u S e r G1 y G1 y A s n G1 y S e i: G i y G i y A s n G1 vr ·Τ h r G .1 aA s p 40 CysSerPheGinHisSerPrclieSerSerAspPhsAlaValLys11eArgGIu Le u S e r

AscTyrLeuLeuGlnA〇οT'/rPrοVaIThrVaiΛ1aSerAsnLeuG1n SEQ ID MO :531 ' 45 pMCN3 2 3 3 3. pep

A1 aAs r.Cy s S erlleMec工 1 eAspGl u lie工 leHisHi s LeuLy s Arg ProProAlaPro L e u L e u A s p P r o A s nA s n L e'j A s nA s p G1 u A s p V a 1S e r I i e L e u M e t A s p A r g A s n L e u Λ r g L e u P r c A s π L e u GI u S e r ? h e' / a 1 r g AI a V a 1L y s A s n L e u G1 u A s 1 a 3 e r G1 y 50 I i eG i u A i a 工 1 e LeuAr ς: As nLe uG 1 n ? r cC>'s L eu ? r 3 S e r A1 aT hr A12A1 a ? r 3 S e r

ArgHis Pro IielielleLysAlaGIyAspTrpGlnGluPhe.^rgGluLysLeuThr?he TyrLeuVaiThrLeuGluGl^AiaGlnGLuGlnGinTyrValGiuGlyGlyGLyGiySer ProGiyGluProSerGlyPro!leSerThrlieAsnProSerProProSerLvsGluSer H i 3 L y 3 S e r ? r o A 5 nr ! e ί: Λ1 a Λ 5 p G1 u G1 u L e u C y 3 G1 y G i \, L e u T r ρ A r g L e u:- / a IL e u 55 AI a G L r g .T r p lM e c G i u A r g L e u L y s T h r V a i A1 a G i y S e r L ·/ s M e:: G L r.G [/ L e ii L e u G1 u A r· / a i A s η T h i: G i u 工 i e H i s ? h e V a i T h r L； y s C;/ 3 A. i a ? h e G i η P:: ο P r 〇 ? i: o S e r C y s L e u A r a ? h e V a 1GI η T h r A s η 11 e S e r A r g L e u L e u GI n GI u T h r S e r G1 u GI n L e u Va 1Λ1 a L e u Ly s ? r οT r p 11 eT h r Ar gG I p.A s n ? he S e r Λr gC y s Le uG I u L euG i nC y 3 G i η P r ο .λ 3 p S e r 3 e r T h r L e u S e r G i y G1 \ -r A s r. G1 y S e r G1 y GI y A s n GI y T h r G1 r. A s p 60 CysSerPheGinHiGSerProILeSerSerAspPheAlaVa iLysIleArgGiuLeuSer A3DTyrLeuLeuGir,AsoT-/r?roValThrValAiaSerAsr1LeuGln SEQ ID MO :532 · 65 CMON32334.pep

AiaAsnCysSerrleMecIIeAspGiuIielleHisHisLeuLysArgProProAiaPro L e u L e u A s p P r ο Λ s n A s n L e，a A s n A s p G i u A s p VH S e r I L 己 L e u M e t A s p Λ rgA s n L e u ArgLeuProAsr.LeuGiuSerPheVdiArgAiavaiLysAsaLeuGiuAs^AiaSerGly 70 iLeGiuAid: ieLeuArgAsnLeiiGinPrcCysLeiiProSerAlaThrAJiaA.LaPiroSGr

ArqH LG 3 ： ie I ie I ieLys AlaGiyAspTrpGlr.GiuPheArgG LuLys LeuThr ?he

TyrLeuva LThrLeuGiuGInAlaGlnGluGinG LnTyrVaiGluGlyGlyGiyGiySer ProG iyG Lu?roSerGly?roIieSerThrIleAsnProSerProProSerLvsGiuSer K L s L y s 〇 e r ? r ^ Λ 3 η M e t AI a S e r L y s M e t G1 n G1 ^ u L e u G1 u A r g V a IA s η T h r G1 u 75 r 1 e H i s ? h e V * a 1T h r L y 3 C y 3 A1 a ? h e G1 η P r o ? r ο P r o S e r C'/ s L e u A r g ? h e V a 1G1 ： 1

O:\92\92747.DOC -219- 200413407

ThrAsnI]_eSerArcgLeuLeiiGlr‘GJLurThrSer'GiuGlnLeuVaiAlaLeuL//srPr:orrrp Ile.ThrArgGinAsnPheSerArgCysLeuGluLeuGlnCysG 丄 riProAspJerSerThr LeuSerGlyGlyAsnGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAsp PheAiaVaiLysIieArgGiuLeuSerAspTyrLeiiLeuGloAspTyrProValThrrVa 丄 AlaSerAsnLeuGinAspGluGiuLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGla ArgTrpMetGluArgLeuLysThrValAlaGiv SEQ ID MO：533 10 pMOM32335.pep 15 20 Λ1aAs nCy 3 S e r11eMe C11eAs pG1u11e11eH i s K1s LeuLysArg Prc ?roAia?ro LeuLeuAspProAsnAsnLeuAsnAspGiuAspValSerlleLeuMetAspArgAsnLeu ArgLeuProAsnLeuGiuSerPheValArgAlaVaiLysAsnLeuGluAsn-AlaSerGIy I leGluAial ieLeuArgAsnIjeLiGInProCysLeuProSerAlaThrAlaAlaPrcSer ArgHisProlielielleLysAlaLGlyAspTrpGinGiuPheArgGluLysLeuThrPhe TyrLeu\/alThrLeuGiuGlnAiaGinGluGinGinTyrValGluGlyGIyGiyGlySer PrcGlyGIuProSerGlyProIieSerThrlLeAsnProSerProProSerLysGIuSer H i s Ly s S e r P r o As a>le CA1 aS e r Ly sM e cG 1 rG 1 y LeuL e uG 1 u Ar g Va I As nT h r G1 u IieHisPheVaiThrLysCysAlaPheGinProProProSerCysLeuArgPheValGIn ThrAsnl leSerArgLeuLeuGinGlxiThrSerGluGlnLeuValAlaLeuLysProT'rp 25

IleThrArgGlnAsnPheSerArgCysLeuGluLeuGinCysGlnPrcAspSerSerThr L e u S e r G1 y GI y As nG I y S e r G1 y G1 y A s r.G I y T h r G1 nA s p Cy s S e r P h eG I nH i s S e r ProIieSerSerAspPheAlaValLys 工leArgGiuLeuSerAspT'yrLeuLeuGinAsp T y r ? r ο V a 1T h r V a i A1 a S e r A s n L e u GI aA s p G1 u G i u L e u C y s G1 y G1 y L e u T r p A r g LeuVa1LeuA1aG1nArgTrpMetGIuArgLeuLysThrVa1A1aGIy SEQ ID MO :534 ^ ^

W P-MCN3233 6 .pep

AlaAsnCysSer IleMetlieAspGluI leIleHisHisLeuL'/sArgPro?roAlaPrci LeuLeuAsp ProAsnAsaLeuAsnAspG luAspVai Ser I i eLeuMe cAspAr gAsnLeu ArgLeuProAsnLeuGluSerPheValArgAiaValLysAsnLeuGluAsnAiaSerGly IleGluAlalleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer 35 ArgHisPrroIlellell eLy s A i aG I* y As pT r pG inG 1 u Ph e ArgG iuLy s LeuThr P he

Ty rLeuVa iThrLeuG1uG i aAlaGIaG1uG1nG1nTyrVa1G1uG i yGIyGIyG1yS e r ProGlyGluProSerGlyProIleSerThr二IsAsnProSerProProSerLysGluSer H i s L vr 3 S e r P r o A s nMe C A1 aAs pG 1 uG I l: L e uC y s G1 yG i y L euT r p Ar g L e u Va 1L e u AlaG1 nArgTrpMe tGluArgLeuLysThrValAlaG1ySerLysMe tGInGIyLeuLeu 40 GluArgValAsnThrGluIieHisPheVaiThrLysCysAIaPheGlr.ProProProSer C y s L e u A r g P h e V a i G1 η T h r A s η 11 e S e r A r g L e u L e u G1 n G1 u T h r S e r GI u G1 n L e u VaiAlaLeuLysPrcTrpIIeThrArgGir^snPheSerArgCysLeuGIuLeuGlnCys G1 n ? r c A s p S e r S e r T h r L e u S e r G1 yG 1 y A s n G L y S e:: G i y G i y A s n G1 v S e r G1 y G y _ As nG 1 y T h r G1 nJ^.s pCy s S e r ?h eG I nH i s S e r P r ο 11 e S e r S e r As p P h e A1 a Va 1L y s 45 1s Ar gG L u L e u S e 2： As pTy r L eu L e uG nAs ρΊ，/ r E5 r ο Va i Thr V’ai A1 a S e r As n L e u

Gin -SEQ ID NO:53 5~ * _ 〇M0^32237.pep 、

AlaAsnCysSerl LeMedeAspGlu二 iel ；LeHisHisLeLiLysArgPro?r.oAla?::o L euL e uAs p P r c As nAs nL e uAs nAs pG i uAs pVa1S e r:i sL euMe 匚As pAr gAs nL eu Ar g L e u ? r o As n L e uG I u 3 e r ?h eVa 1Λ r gA i aVa I Ly s As n L e uG I uAs 1 a S e rG1 y IleGiuAlalleLeuArgAsr.LeuGInProCysLeuProSerAlaThrAiaAlaPrcSer 55 ArgHisProIlelielleLysAlaGlyAspTrpGinGluPheArgGluLysLeuThrPhe .TyrLeu'/diT'hrLeuGiuGinAlaGinGiuGinGlrVTyrVaiGiLiGlyGlyGiyGlySer ProGlyGluProSerGiyProIleSerThrIleAsaProSerProProSerLysGiuSer H i s C y s 3 r P r ο A s r“M e c A i a ? r o ? r c S e i: C y s L 0 u A r g ? h e V a 1G1 η T h:: A s η 工 JL 2 S e r A r g L e u L euG 1 nG I uT hr S e r G1 uG 1 n L eu Va 1AI aLeu Ly 3 P r oT r p I i eT h r Λr gG 1 n 60 AsnPheSerArgCysLeuGluLeuGlnCysGInProAspSerSerThrLeuSerGIyGly AsnGU/ThrGlriA^pCysSerPheGinHisSerProIleSerSerAspPheAlaVaiLys I leArgGLuLeuSe'rA-pTyrLeuLeuGirLAspTyrProVaiThrValAiaSerAsnLeu Gln^.spGluGluLeuCysGlyGiyLeuTrpArgLeuValLeuAlaGlnAirgTrpMetiGlu Arg L e u Ly s T h rV a 1AIaGIy S e r Ly s Me tG1nGlyLeu LeuG1uArgVaIAs nThrG1u 65 IleHisPneVaiThrLysCysAiaPheGinPro SEQ ID MO :536 OM0M3233S.pep 70 Al_aAsr‘C-_/：3S>"2i：IieMecI； iePvspGiuIielleHisHiolieuLysAirgPrroPiroAid?：：·：) LeuLeuAsc?roP.snAsnLeuAsnAspGluA3pValSer £ LeLeuMetAspArgAsnLeu Arg Lei.： ?r nL-suG i u3er PheVa LArgAiaV a LLysAsnLeuG iuAs nA iaSerG Ly

IleGLaAlarleLeuArcjAsnLeuGlnProCysLeuProSerAlaThrAiaAiaProSer ArgHis ?r z lie l lei LeLysAlaGi'/AspTrpG InG iuPheArgG luLysLeuThrPhe 15 Tyr LeuVa iThr LeuG iuG 1 nAlaGlnG luO inG I nTy rV a 1G LuG L'/G I yG I yG ly Ser

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ProGlyGluProSerGiyProl LeSerThr：：丄eAsriProSerProProSerLysGluSef HisLysSerProAsruMetAiaPrroProSerCysLe'uArgPheVa 丄 GlrVThrAsnlleSer A r g L e u L e u G1 n G1 u T h r S e r G1 u G1 n L e u V a IAI a L e u L y 3 P r ο T r p 11 e T h r A r g G1 n Α3η?Κ35θ：τΑι：9ζ：ν-；Ξΐ>>0ΐι〇1/αΙ^<5']Ο1ηα：/3〇1ηΡΓ〇Α5ρ30；Γ3ί5ΓΤ!ΐΓί^θ\_ι3β::Ο1·，/Ο ly 5 AsnGl/SerGi’/GlyAsnGiyThrGinAspCysSerPheGlnHisSerProIleSerSer AspPheAlaVaiLys I leArgG LuLeuSerAspTyirLeuLeuGInAspTyrPrcrvAalThr V a i Λ i a S e r A 3 n L e u G1 n A s p G1 u G i u L e u C y 3 G1 y G i y L e u T r p A r g L e u V a IL e u AI a G1 oArgTrpMe tG 1 u/\rgLeuLy sThrVa I Ai aG 1 y S erLy sMe tG 1 r.G ly LeuLeuG I u ArgVaiAsnThrGIuIIeHi3PheValThrLvsCv3AlaPheGln?ro S：£Q ID 10 MO：537 PMCM32339.pep 15 Al aAs nCy s Ser 11 eMe c 11 e As pG 1 u I i e 11 eH i s H i s LeuLy s Ar g Pr 〇 ?r 〇 A丄 a P i: 〇

LeuLeuAspc?AsnAsnLeuAsnAspG luAspVa 1Se i: I ieLeuMe tAspArgAsnLeu A r g L e u P::〇 A s n L e u G i u S e r ? h e'/ a 1A r g A1 a V a 1L·/ s A s n L e u G1 u A s n A 丄 a S e it G 丄 ’/ 11eGluA1a11eL euAr gAs n L euG1η P r oCy3 Le u ? r o S erAi aThrAIaAIa P r o S e r ArgH is ProIlellelLeLysAlaGi yAs pTrpG i nGIu ?heArgG1uLys LeuThr Phe 20 Ty r L eu Va IT hr L euG l uGI I aG 1 nG 1 uG I nG I nTy r V a IG1 uG1 yG1 y GI yG1 y S e r

PrcGiyGluProSerGlyPro IleSerThrIieAsnProSerPro ProSerLysGluSer HisLysSe::ProAsnHetAia·?SerCysLeuArgPheValGlnThrAsril LeSer Ar g L e u L euG i nG i u'T h r S e rG i uG i n L e uT'/a 1A1 a L e u Ly s ? r oT rp 工 1 eT hr Ar gG 1 n AsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuSerGiyGiy 25 As nGIy S e rG1yG1yAsnG1y S e rG1yG1yAs nGIyTh rGInAs pCvs S e r P heG1nH i s

Ser ?roI leSerSerAsp-PheAlaValLyo I ieArgGluLeuSerAspTyrl.euLeuGia A s p T y r ? r ο V a IT h r V a 1A1 a S e r A s n L e u G1 nA s p G1 u G1 u L e u C y s GI y GI y L e u T r p A r g L e u V a 1L e u AI a GI n A r g T r p M e c G1 u A r g L e u L v s T h r ·/ a 1A1 a G1 y S e r L y s M e t G1 r* GI y L e u L e u GI u Λ r g' / a IA s η T h r G1 u 11 e n i s ? h e V a i T h r L y s C y s ΛI a ? h e G1 n 30 Pro SEQ ID MC：533 PMCN32364.pep 35 AI a A s n C y s S 0 r 11 e M 01:1 L e A s p GI u 11 e 110 H i 3 H i 3 L e u L y s A r g ? r o ? r o A 3 n ? r o

LeuLeuAspPrcAsnAsnLeuAsnSerGliiAspMecAspIleLeuMetGluArgAsnLeu Ar gThr ? r cs nL euL e '.I AI a ? he Va 1 Ar g A1 aVa 1 Ly s H i s LeuG 1 uAs I a S erGI y IleGluAialieLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer ArgH isProIleIlelleLysAiaGl :/As pTrpG i nG i u PheArgG1uLys LeuThr Phe 40 Ty r L e u Va IT h r Le uG 1 uG I πΛ I aG 1 nG 1 uG I nG 1 p.Ty r V a IG i uG 1 yG1 y G1 y G i y S e r

ProGiyGluProSerGlyProIleSerThrIleAsnProSsrProProSerLysGluSer HisLysSerProAsnMe tAiaThrGlriAspCysSerPheGinHisSerProlleSerSer Asp? h e A1 a Va 1L y s 11 e Λ r gG 1 u L e u S e r A s pTy r L e u L e uG i s p Ty r ? r ο V a 1T h r Va 1A1 aS e r As nL euG i πΛspG 1 uG 1 u LeuCy sGIyG1 y LeuT r p Ar g Leu Va ILeu.^ 1 a 45 G1nArgTrpMe tG L uArg LeuLys ThrVa iA丄 aG iyS e rLys Me cG1nG1yLeuLeuG iu

ArgValAsnThrGluIieHis PheValThrLy〇CysAla?heGLn?ro?ro?roSerC-/s LeuArg ?h eVa1G1nThrAs nlie SerArgLeuLeuG1nG i uThrSerG1uG1n LeuVa1 AI aL eu Ly 3 P r oT r ρ 11 eT hr Ar gG I n As η P h e S e r Ar gC y s L euG 1 u L euG 1 nCy s G1 n Pro SEQ ID MO：539 50 Λ pMOM3 2 3 77. pep A1 a A s n C y 3 S e r 11 e M e t e A s p G i u 工 1 e 11 e H i s H i s L e u L y s A r g P r 3 ?:: o A s n ? r o 55 L e u L e u A s p ? r 0 A 3 nA 3 n L e' j Λ s r. S e r G1 u Λ s p M e t Λ 5 ρ 11 e L e u M e t: G1 u A r g A s n L e u A r g T h r ? r o A s n L e u L e u Λ i a ? h e' / a 1Λ r g A1 a'/ a 1L y s H i 3 L e u GI u A s n A i a S e r GI y IieGluAiaileLeuArgAsnLeuGinPrcCysLeuProSerAiaThrAiaAiaProSer ArgHis Pro ILeI LeiLeLysAiaGLyAspTrpGInGluPheArgGluLysLeuThrPhe TyrLeuValThrLeuGluGinAIaGinGiuGlnGLaTyrVaiGluGIyGLyGiyGlySer 60 ?roGiyGlu?roSerGiyProlleSerThrIleAsnProSerProProSerLysGluSer H i s L y s S e r P r· c Λ s r“M e t Λ i a 丁 hG1 nA s p C，/ s S e r ? h e G1 η H i s :5 e r P:: c; 11 e S e r S e r AspPheAlaVaiLys11^ArgG iuLeuSerAspTyrLeuLeuGlaAspTyr PrcVaiThr Va IA1 a S e r A 3 n L e uG I ηΛ s pG i uG i u LeuCy s GI y G1 y L euT r p A r g L'e u Va 1L eu A1 a G i nA r g，r r p Me c: G 丄 u A r g L e u L y s T r Vd 1A i aGy S e it L y s M e c G i nG i:/ L e'j L euG i u 65 ArgValAsnThrGluIieKisPheVaiThrLvsCysAlaPheGlnPrcProProSerCys LeuArqPheVaiGlr.ThrAsnlleSerArgLeuLeuGlnGluThrSerGluGlnLeuVal

ProAspSerSerThrLeu SEQ :D NO：590 70 pMCM3 2 3 5 2. pep

AlaAsnCysGer·：： LeMec IleAspGiuIiel leHi：sHisLeu：L、/sAi:gPrc?:roAs;nPi:o L «5 u L ΰ u A · 3 p ? ir c A :· 5 η Λ 3 n L u A s n S e i: G j A s ρ M 21Λ .3 ρ I i e L e Li M e 匕 G i u A r* g A s n L e u 75 ArqThrPrcAjnLeuLeuAiuPhfi'/aiArgAidVaiLYGHisLeuduAsrwAidSerG 丄'/

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IleGluAlalieLeuArgAsnLeuGlnProCysLeuProSerAiaThrAlaAlaProSer ArgHisProIl^IielleLvsAlaGLyAspTrpGlnGluPheArgGluLysLeuThrPhe TvrLeuValThrLeuGluGInAlaGinGlLiGlnGinTyrValGluGiyGiyGlyGlySer ProGivGiuProSerGlyProIIeSerThrlleAsnProSerProProSerLysGluSer 5 HisLysSerProAsnMetiAlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeu AlaGirL^rgTrpMetGIuArgLeuLysThrVaiAlaGlySerLysMetGlnGlyLeuLeu GluArgValAsaThrGlulleHis PheValThrLysCysAlaPheG inProPro ProSer CysLeuArgPheVaiGlnThrAsnlleSerArg乙euLeuGlnGluThrSerGiuGlnLeu VaiAIaLeuLysProTrpIleThrArgGlaAonPheSerArgCysLeuGluLeuGlnCys 10 GlnProAspSerSerThr LeuSerrGlyGlyAsnG lySerGl'/G lyAsnGLyThrGlnAsp

AspTyrLeuLeuG1 p^spTyr?roVaiThrVaΙΛIaSerAsnLeuGin SEQ ID MO:591 15 piMOM32 353 .pep

AlaAsnCysSerIleMetlleAspGiuIielleHisHisLeuLysArgProProAsnPro LeuLeuAspProAsnAsnLeuAsnSerGluAspMetAspIieLeiiMetGiLiAr'gAsnLeu 20 Ar gThr ?r oAsnLeuLeuA 1 a P heVal Ar gAl a Va 1 Ly s H i s LeuG 1 uAs nAl aS erG 1 y

IleGluAlalieLeuArgAsnLeuGln?roCysLeu?roSerAlaThrAlaAlaProSer

ArgHisProIlelielieLv^sAiaGlyAspTrpGinGluPheArgGLuLysLeuThrPhe TyrLsuValThrLeuGluGlnAlaGlnGiuGlriGinTyrVaiGiuGlyGiyGlyGiySer _ ProGlyGluProSerGlyProIieSerThrlleAsnProSerProProSerLysGluSer 25 H i s Ly s S e r ? r o As ni^le t: Λ1 a As pG I uG 1 u L e uCy s GI y GI y L e uT r p Ar g L e u Va 1L e u

AlaGlnArgTrpMetGluArgLeuLysThrVaiAlaGlySerLvsHetGlnGlyLeuLeu GiuArgVaiAsnThrGluIIeHis?heValThrLvsCysAla?heGln?ro?ro?roSer CysLeuArgPheValGinTInrAsnIleSerArgLeuLeuGInGluT'hrSerGiuGInLeu ValAiaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGInCys 30 G1 η P r 〇 As p S e r S e r T h r L eu S e rG 1 yG 1 y As nG 1 y S e r G1 yG 1 y As nG I y S e r G1 y G1 y

AsnGlyThrGInAs pCys Se r PheG inHi s Ser Pro 11eSerSerAs p PheAlaVa1Lvs IleArgGiuLeuSerAspTyrLeuLeuGinAspTyrPiroValThrValAlaSerAsnLeu Gin 3EQ ID NO:592 35 PMON32354.pep

AlaAsnCysSerll eMe 匕 I ]. e A s pG 1 u Ϊ1 e 11 e H i s H i s L eu L<y s Ar g P r o ? ::〇 As n ?r o LeuLeuAspProAsnAsnLeuAsnSerGluAspMecAspIieLeuHetGiuArgAsnLeu Ar gT h r ? r ◦ As n L e u L eu A1 a P h e Va 1 Ar g a'/a 1 Ly s H i s L euG 1 u As nA 1 a S o r G 丄；/ 40 IleGluAlalleLeuArgAsnLeuGinProCysLeuProSerAlaThrAlaAlaPrcoer Ar gi s ? r ο 11 e 11 e 11 e Ly s AI aG 1 y As pT rpG i nG 1 u Ph eAr gG 1 u Ly s LeuT hr ? h e TyrLeuVaiThrLeuGluGinAlaGlnGiuGlnGlnTyrValGluGIyGlvGiyGlySer ProGlyGiuProSerGlyProIleSerThrlleAsriPiroSerProProSerLysGluSer 一 H i s Ly s S e r ? r οΛ s nMe t AI a 3 e r Ly s Me t G i nG 1 v L eu L euG 1 u Ar g Va IA s nT h r GI u 45 IleHisPheVaiThrLysCysAiaPheGlnProProProSerCysLeuArgPheValGla ThrAsnlleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLys ProTrp IleThrA^rgGlnAsnPheSerArgCysLeuGluLeuGinCysGlnProAspSerSerThr LeuSerGi y G1 y As nG I y T h r G1 s OCy s S e r ? h eG I η H i s S e r ? r ο 11 e S e r S e r As p _ PheA i a'/a 1 Ly s 工 i luLeuSepAspT'yr LeuLeuG LnAspTyr iThr'/a ]_ 50 AI a S e r A 3 n L e uG 1 nAs pG 1 uG 1 u L e uC y s GI y G i y L e uT r p Λ r g L e u Va IL e u AI aG 1 n

ArgTrpMecGiuArgLeuLysThrVaiAiaGly SEQ ID h〇:593 PMON32355.cec 55 A· 1 a A s n C y 3 S e j:工 i e M e c 工 1 e A s p G L u I ! e I i e H i s H i s L e u L y s A r g P r ο P r q A s η P r o LeuLeuAspPror'.sr.AsnLeuAsnSerGluAscMe tAsp I leLeuMecGl-j.ArgA〇rXeu Ar gT hr ? r oAs n LeuLeuAl a PheV’a i Ar gAl a:，/a 1 L‘/s H i s LeuG 1 uAs nA i a SerG ly I leGIuAlalleLeuArgAsnLeuGlaProCysLeuProSerAlaThrAlaAlaProSer 60 ArgHis ?roIleIleileLysAlaGiyAspTrpGInGiuPheArgGluLysLeuThrPhe

TyrLeuVaiThrLeuGluGInAlaGlnGiuGLnGlnTyrValGiuGlyGlyGiyGiySer ProGlyG iuProSerGlyProIleSerThrILeAsnProSerProProSerLvsGluSer HI i s Ly s S e i: P r: o As nMe CAl a S e ϊ： Ly sMe CG i nG i y Le u LeuG 1 u Arg'/a 1 As nT h rG L u __ 工 1 e H i s ? h e V a 1T h:: L y s C y 3 A1 a ? h eG i r‘ ？ r·〇？ o ? j: g S e r C y 3 L e u Ar g ? h e Va ]_ G i n 65 ThrAsnl ieSerArgLeuLeuGir.GluThrSerGluGiaLeuValAlaLeuLysProTrp I i e T n r A r :j G i n. A s η P h e S e r A r g C y s L e u G1 u L e u GI n C y 3 G1 n ? r o A s p S e r S e r T h r L e u S e r G i y G i y A s n G1 y 5 e r GI v* 1 y Λ s n G1 y T h r G1 nA s p C y s S e r P h e G i n ：4 i s 〇 e r P Ϊ： c I i e S e:: S e r· A s p ? h e A L λ V a i L y s r 15 A:: ς G L u L e u S e:: A s p T V，r L e u L e u G 丄 n A S p ^ TyrProVaiTi^rValAlaSerAsnLeuGlnA^pOluGluLeuCysGiyGiyLeuTrpArg

/0 L e u V a i L e u A1 a G L Λ r '-.r T r p M e c G1 u A r g L e u L '/ s T h r / a i AI a G 1 y SZQ ID MG:594 " * * pMON3 ：： 5 6 . 〇.-p 75 '

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AiaAsnCysSerl ieMet: I ieAspGi'jZ leI ieHisHisLeuLysArgProP;:oAsnPi:〇

LeuLeuAsp ProAsnAsnLeuAsr.SerG luAspMetiAspI leLeuMe tGluArgAsnLeu ArgThr.?roAsnLeuLeuAla?heVaiArgAlaValL7sHisLeuGiuAsnAla5erGly IleGluAla：[]LeIJeuA:rgj\£；nIJeuGLnPr*oCysL；euPi:oSer'Alarrhi:AlaAia?r'〇Sei: 5 ArgHisPro iLellelieLysAlaGiyAspTrpGinGiuPheArgGiuLysLeu-ThrPhe TvrLeuValThrLeuGiuGlriAIdGinGiuGlnGip.TyrVaiGiuGlyGiyGlyGiySer ProGlyGluProSerGiyPro IieSerThrIleAsnProSerProProSerLysGluSer HisLysSerProAsnMetAiaSerLysMscGlnGlyLeuLeuGiuArgValAsnThrGlu IleHisPhe'/aiThrL./sCysAlaPheGinPrcProProSerCysLeuArgPhe'/alGln 10 ThrAsriI leSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLys ProTTrp IleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlaProAspSerSerThr LeuSerGiyGlyAsr.GlySerGlyGlyAsnGlySerGlyGlyAsnGlyThrGip^spCys SerPheGlnHisSerPrcIleSerSerAspPheAlaVaijLysIleArgGluLeuSerAsp T y r L e u L e u G L nA s p T y r P r ο V a 1T h r V a ϊ λ I a S e r A s n L e u G i nA 5 〇 G L u G1 u L e u C y s 15 G1yG1yL e uT rp Arg L euVa1L euAIaG1aAr gT rpMe tG1uA r g L eu Lv s T hrVa1AIa Gly 3EQ ID MO：595 ^ ▲ dMON3 2 3 5 7.oep 20 ‘ '

Al aAs nCy s S e r 11 eMe t 二 i eAspG i u 11 e 11 eH i H i s LeuLy s Ar g ?r 〇 ?r 〇 As nP ro LeuLeuAspProAsnAsnLeuAsnSerGluAspMecAspIleLeuMecGluArgAsnLeu Ar gT hr P r o As n L e u L eu A1 a ? he Va I Ar g A1 a V a 1L· y s H i 3 L e uG i uA s I a S e r G1 y IleGluAlalleLeuArgAsnLeuGInProCysLeuPrcSerAIaThrAiaAlaProSer 25 ArgHisProIlelleiieLysAlaGlyAspTrpGlnGluPheArgGiuLysLeuThrPhe TyrLeuValThrLeuGIuGlrJUaGlnGluGlnGlnTyrVaiGiuGiyGiyGlyGlySer ProGlyGii:ProSerGl:/Prc)I IeSerThr I leAsnProSer ProProSerLysG iuSer H i s Ly s 3 e r Pr c As nMe tAla?ro?ro S er Cy s L eu Ar g ?he Va IGI nThr As η 11 e S er 30 Asn?heSerArgCysLeuGiuLeuGinCysGlrx?roAspSerSerThrLeuSerGlyGly As nG 1 yT hrG1 nAs pCy s Se r ?heG 1 nH i s Se r ?r ο I i eS e r Se r Asp ?he A i aV*a i Ly s G1 nAs pG 1 uG I u LeuCy sG 1 yG l y LeuT rp Ar g LeuVa 1L eu A1 aG I nAr gT r pMe tG 1 u Ar g L e uL· y s Thr Va i A1 aG 1 y S e r Ly s Me c G1 nG 1 y L e u L e uG I uAr g Va i As r.T hr G i u 35 IleKisPheValThrLysCysAlaPheGlnPro SEQ ZD NO :596 pMOM3 2 3 5 3. pep

40 M aAs nCys S e rIi eMe 111eAspG iu 工1e11eH i s H i s LeuLys Arg Pro ProAsn ?ro L e u L e u A s p ? r o A s aA s n L e u A s n S e r G i u A s p M e t: A s p 11 e L e u M e c G L u A r g A s r. L e u ArgThr?r3AsnLeuLeuAiaPheValArgAlaValL//sHi sLeuGiuAsnAlaSerGLy 工leGiuAialleLeuArgAsnLeuGlnProCysLeuProSerAiaThrAlaAlaProSer ArgHisProIlellelieLysAiaGlyAspTrpGlrxGiuPheArgGluLysLeuThrPlie 45 TyrLeuValThrLeuGluGlr^iaGInGliiGlnGinTyrValGluGiyGlyGIyGlySer ProGlyGluPro:3erGly?r〇IleSerThr IleAsriProSerProProSerLysGiuSer HisLysSerProAsaMetAiaProProSerCysLeuArgPheVaiGlnThrAsnlleSer Ar gLeuL euG i nG 1 uThr S e rG 1 uG I tnLeu Va 1AI aLeuLys ? r oT rp 11 eTh r Ar gG 1 n AsnPheSerArgCysLeuGluLeuGlntysGinProAspSerSerThrLeuSerGiyGiy 50 As nG 1 y S e r GI yG 1 ·/As nG I yT hr GI nAs pCys S e r PheG InHisSerProlieSerSer A s p ? h e AI a V a IL y s I i e A r g GI u L e u S e r A s p T r L e u L e u G1 s p T y r ? r oT / a 1T h r V a 1A1 a S e r Λ s n L e u G1 s p G i u G1 u L e u C y s G1 y G1 y L e α T r p A r g L e u V a 1L s u A1 a G i r g T r p M e t G i li A r g L e u L v s T h r V a 1ΛI a GI y S e r L y s M e c： G i n G1 y L e u L e u GI u ArgVa i As nThrG i工 i eH i s PheVa iThr LysCys Al a PheG Ln? ro SEQ ID 55 MO：597 * * pMOM3 2 3 5 9. pep 60 A1 a As nC y s 3 e r ： 1 e Me c 11 e As pG 1 u 11 e 11 e H i 5 H i s L e u Ly 3 A r g ? r c P r 〇 As n ? r 〇 L e u L e u A 5 p P r o A s a A s n L e u A s n S e r G1 u A s p M e c A s p 11 e L e u M e t G l u Λ r g Λ s n L e u ArgThr P r oAs n Leu LeuA La PheVa LAr g Ai aV a 1 Ly 3 H i s LeuG 1 uAS nA .1 aSe rG 1 y IieGluAia工 ieLeuArgAsnLeuGlnProC'/sLeuPr〇SerAiaThrAiaAiaProSer ArgHLSProIieHelleLysAlaGLyAspTrpGlnGiuPheArgGluLysLeu.ThrPhe 65 TyrLeuValThrLeuGLuGinAlaGinGIuGlnGinTyrValGLuGlyGiyGlyGlySer ProGlyGIuProSerGiyPro IIeSerThrIleAsaProSerProProSerLysGluSer HisLysSerProAsaMecALaProProSerCysLeuAraPheValGlnThrAspLl leSer ArgLeuLeuG inGiuThrSerGiuGlnLeuVaLAlaLeu^ysProTrpIleThrArgGln A s η P h e S e r r q C y 3 L e u G i u L e u G1 π C y s G1 π P r o A s p S e r S e r T h r L e u :3 e r G1 y G1 y 70 ΛsnG 1 ·/Se r'J； L'/C1 y AsnG I y SerG LyG1 yΛsnG1 yThrG Lr.A3pC'/s ier PheG ir.H i s

Ser ?r c; [ i eSe r Ser As ρ PeA iaVa 1Ly s I i eAr gG iuL<euSe r AspTy r L，ξuLeuG i n A s p T r ? r ^ ·/ a L T h r V a i Λ i a 3 e r Λ s ri L e u G i nA s p G1 u G1 u L e u C s G L y G1 y L e u T r p

ArgLeuVa iLeuAlaGlr.ArgTrpKetGluArgLeuLysThrVaiAlaGlySerLysMet G1 n G i ν' - ^ ^ ^ u G1 u Λ r ga IA 3 nT h r C L u 11 e H i s P n e V a 1T h r L y 3 C 3 Λ1 a ? h -a G1 n 75 Pro 3£Q ：3 MO ： S 98

O:\92\92747.DOC -223 - 5200413407 10 15 20 pMON32360.pep A i aAs nC，/s Se r I i eMe t ϋ i eAspG i u I i e 工 i eH i s H i s LeuLy s Ar g Pro P !：〇 As π P ro LeuLeuAspProAsnAsnLeuAsnSerGluAspMetAspIieLeuMetGluArcjAsnLeu ArgThr Ly IieGluALalleLeuArgAsnLeuGinProCyoLeuProSerAlaThrAlaAlaProSer T y r L e u Va IT h r L e uG 1 uG 1 pJ^ I aG 1 r.G I uG i nG 1 nT y r ·/ a i G1 uG 1 yG i y G i y GI y S e r ProGiyGluProSerGIyPrcIieSerThrIleAsnProSerProProSerLysGluSer HisLysSerProAsnMetAiaAspGluGiuLeuCysGlyGlyLeuTrpArgLeuValLeu AI a G i ηΛ r g T r p M e C GI u A r g L e u L y s T h r V a IA1 a G1 y S e r L y s M e t G1 n G1 y L e u L e u GluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProProSer Cy s L >2 uAr g Phe Va 1G1 nThr As η 11 e S e r Ar gLeuLeuG 1 nG 1 uThr Se rG1 uG 1 nLeu Va L A l a LeuLy s P r oT r p 11 eT hr Ar gG I nAs η P he S e r Ar gC y s LeuG 1 uLeuG 1 nCy s G1 n ? r c As p S e r S e rTh r Le u S e rG1 yG i y S e r G i y S e r GI yG 1 y S e r G i yT h r G1 nAsp CysSerPheGlr.HisSerProIleSerSerAspPheAlaVaiLysIleArgGIuLeuSer AsDTyrLeuLeuGln.AsOT'/r?roVaiThrValAiaSerAsnLeuGIn SEO ID NO：599 ' 25 30 35 40 pMCxM323 62 .pep Αΐ3_Α5Π〇，/3；3θ；Γΐ1·9Μθί:Ι1θΑ3ρΟ1'αΙ1；2ΐΐ5ΗΪ3Η:ΐ3ΐι<0ΐι：^/3Α：Γ9Ρ；Γ〇Ρ::〇Α3ηΡι:〇 LeuLeuAspProAs nAs nL e uAs n S e rG1uAs pMe cAs p11e L euMe cG1uArgAs nL eu ArgThrProAsnLeuLeuAiaPheya 丄 ArgALaV’alLi/sHisLeuGluAsnAlaSerGly I]_eGiuAiaIleLeuArgAsnLeu0inProCysLeu?rcS«erAla.ThrAlaAla?roSer ArgH s ?ro 11 e I le IL eLysALaG iyAspTrpG inG iu ?heArgG luLys LeuThr Phe TyrLeuValThrLeuGluGlnAlaGinGiuGlnGinTyrValGluGlyGiyGIyGlySer ProGlyGluProSerGlyProIleSerThr工 ieAsn?roSer?roPr〇SerLysGluSer Hi s Lys Ser ?r〇As nMe cAiaAspG iuG i uLeuCy sG lyG Lyljeu.TrpArgLeuVaiLeu A1aG1nArgT rpMe tG1uA rg L eu Ly 5T hrVaIΛIaGIyS e r Lys Me tG1nG iv L euLeu GluArgValAsnThrGiuIieHisPheVaIThrLysCysAla?heGInPro?roProSer CysLeuArgPheVaiGlnThrAsnlleSerArgLeuLeuGlnGiuThrSerGiuGinLeu V a 1AI a L e u L y s P r ο T r p I i e T h r A r g G i nA s n ? h e S 0 r Λ r g C y s L e u GI u L e u G1 n C y s GlnProAspSerSerThrLeuSerGlyGlySerGlySerGlyGlySerGlySerGlyGiy S e rG1yTh rG1nAs pCys SerPheGinHisSerProIleSerSerAspPheAlaVa i Lys IleArgGIuLeuSerAspTvrLeuLeuGlnAspTyrProVaLThrValAlaSerAsnLeu Gin SEQ ID NO：600

45 50 55 60 PMON32392.pep AlaThrGirL^spCysSerPheGinHisSerProIieSerSerAspPheAlavalLys HeArgGluLeuSerAspTyrLeuL^gi^SiTyrPruValTurValAleSernSnLeuGln As pG i uG i u l euC y s G1 yG 1 y L e uT r pAr g L e uVa IL eu A i aG 1 p^.\r gT r p Me t G1 uAr g L· e u s T h r Va i A1 aG 1 y S e r L y s M e tG 1 nG 1 ：/ L e uL e uG 1 u Ar g V a i A s n.T h r G u 11 e H i s ? n e · / a i T h r L y 3 C y s ΛI a P h e G1 n ? r ο P r o ? r c S e r C y s L e u A r g P h e * / a IG1 η T h r AsnlieSerArgLeuLeuGlnGiuThr^erGiuGlnLeuVaiAiaLeuLysProTrpIIe T h r y g G s η P h e S e r A r g C y s L e u G i u L e u G i n C y s G i ri ? r c T y r V a i G1 u G i y G i v GlyulySerProGiyGiuProSerG LyProIieSerThrlleAsnProSer?ro?roSer LysGIu S e r H i s Lys S e r P r oAs nMe cA1aAs nCy s 3 e r11eMe tIIeAs pOlullelie ^iisHisLeuL'/s ArgPr'oProAsnProLeuLeuAspProAsaAsnLeuAsnSerGluAsp 〒 fP 二上 e L e u M e t G L u A r g A· s n L e u A r gT h r ?o A s n L e .*! L e A1 a ? h e V a i A r g A i a yaiLysHisLeuGi'jAsnAiaSerG 1二/工 ieGiuAia工 i f o s e r A i aT hr A!_ aA 1 a ? r o Ser Ar g HisPiroIlellelicsLysAlaGL y AspT r p G i nG ^ u ? h e Ar gG 1 u L y s L e u T h r ? h eT y r L e u Va IT h r L e uG 1 uG i nA 1 aG I nG 1 uG 1 n Glr\ 3EQ ID MO： 601 一 65 70 pMOMj, ^ 9 3 _ pep A1 a Jt h r ^ A s p C y s S e r P h e G1 η H i s S e r P r ο 11 e S e r S e r Λ s p ? h e A1 a V a IL y s XI e A r g 〇 1 u l e u S e r A s p T y r L e u L e u G1 n. A s p T y r ? r ο V* a 1T h r V a 1A1 a S e r A s n L e u GI n A s p y I u ^ u 乙己,a 匚 y s g L y G1 y L e u T r p A i· g Ij eV’ a i L e u A i a G1 nA r g T r p M e 匕 GI u A r g 匕产 u u :·/ 3 T h r' /a 1A Ϊ aG 1 y S e r L·/ s M e 匕 G i nG 1./ L e u L e uG i u A r g V a 1A s n.T hr G1 u I i e ^1 s =卜1 e V a IT1 h r L y s C y s A i a P k e G L η P r c ? r c ? r o S e r C y 3 L e u A r g P h e V a 丄 G1 η T h r 么‘sn i leSe ：：a：：$leuLeuGinG1·uThrSerGl·uG ir:LeuV.a i AiaLeuLy3 ProTrpI ie T h r A r g c L a 5 p. ? h e 5 e r Λ r cj c ： y s L e u GI u L e u G1 r. C y s G 1 r. ? r o A 3 p S e r $ e r T h r L e u TyrYa W 丄yG iyG er ProG iyGiu?r jSerG i，/?rc ^ ?^〇：?er-〇SerLy3GLuSerHi3LysSer?roA3nMer.AlaAsnCyGSer IleMet ie^spG j_ei ]_eKj_sHisLeuLysA::gPir·:: ?rcAsnPrcLeuL<euAsp?rcAsnAsn LeuAsnSerGluAspMetAopr LeLeuMecGluArgAsnLeuArgThrProAsnLeuLeu AldPhe7.ii iArgAici\AilLysHisLeuGiuA：sr‘Aici;5erGiv，UeGiuAlaIieLeuAra O:\92\92747.DOC 224- 200413407

AsnLeuGlnProCysLeu?roSerAlaThrAlaAia?roSerArgHisPro lieHells LysAlaGlyAspTrpGlrLGluPheArgG LuLysLeuThr PheTyr LeuValTnr LeuGlu GlnAlaGinGluGlnGln SEQ ID MO：602 OM0N32396.pep

AiaAsnCysSerIIei4etIleAspGluIlelleHisHisLeuLysArgProProAsnPro LeuLeuAspProAsr^snLeuAsnSerGluAspMecAspr ieLeuMetiGluArgAsnLeu 10 Arg.ThrProAsnLeuLeuAlaPheValArgAlaVa LLysHisLeuGluAsnAlaSerGiy I ieC iuAialleLeuArgAsnLeuGln?roCy3 LeuProSerAlaThrAiaAlaProSer ProHis Prol leliel leLysAlaGiyAspTrpGlnGIu?heArgGi.uLysLeuThr ?he TyrLeuvaiThrLeuGiuGin^*iaGlnGluGlnGlnTyrVaiGiuGiyGivGlyGlySer _ PircGiyGiLiPiroSerGiyPro 工 ieSerThr 工 leAsriProSerProProSerLysGluSer· 15 HisL'/sSerProAsrLMetAlaThrGlriAspCysSer ?heGinHisSer?ro 工 leSerSer

AspPheAiaValLysIleArgGluLeuSerAspTyrLeuLeuGinAspTyrProValThr Va 1A1 a S e r As n L e uG 1 s pG i uG 1 u L e uC y s G1 yG 1 yL e uT r p Ar g LeuValLeuAla G1 riA. r g T r p M e c C-1 u r g L e u L y s T h r V a IA1 a G1 y S e r L s M e t GI r. G1 y L e u L e u G1 a ArgVa1As nThrG1u11eH i s ?heVaIThrLys Cys A i a PheG1nGIuTh rS e rGIuG1a 20 LeuValAiaLeuLys PrcTrpI leTThrArgGlnAsriPheSerArgCysLeuGluLeuGln CysGlnProAspSerSerThrLeu SEQ ID NO:603 ^ pMOM32371.oep 25 ^

AlaAsnCysSerIIeMe tl leAspGluI lei leHisHisLeuLysArg?!·〇?::〇AsnPro 乙 euLeuAspProAsnAsr;LeuAsnSerG]_uAspMet:AspIleLeuMetGiuA::gAsnLeu ArgThr Pr oAsnLeuLeuAla PheVaIArgAIavaILysH i s LeuG1uAs η-Λ IaSerGly I i e G i u A i a 11 e L e u A r g A s n L e u G1 η P r o C v s L 0 u P r o S e r AI a T h r A1 a Λ i a ? r o S e r 30 Ar gH isProIlellelle Ly s Al aG 1 '/As pTrpG l nG 1 u PheArgG luLy s Leu.Thr Phe

Ty r Leu Va IT hr LeuG 1 uG I ηΛ i aG I nG 1 uG I p.G i nTy r Va IG1 uG 1 yG I yG lyG I y S er ProGiyGlu?roSerGly?iroIieSerThrIleA；sn?roS>0r?roPi:oSerLysGluSer H i s L y3 S e r ? r o As nMe t A i aA s pGIuG1uL· euC ys GIyG1yLeuT rpArg L e uVa1L eu ^ A1 aG i r^Ar gT r p Me t: G1 uAr g L e uL· y s T h rVa 1AI aG 1 y S e r L y s Me t: G1 nC-1 y L e u L e u 35 GluArgValAsnThrGiulleHis PheVaiThrLysCysAlaPheGinProProProSer

Cys L euAr g P h e'/a iG i n.Thr As η 11 e S e rArgL e uL e uG i nG 1 uT hr S e rG 1 uG 1 nL eu ValAlaLeuLysProTrpIleThrArgGlrLnsnPheSerArgCysLeuGiuLeuGlnCys GlnPrcAspSerSerThrLeuGLyGlyGlySerGlyGIyThrGlaAspCysSerPheGin. H i s S e r ? r ο11e S e r S e rAs p Ph eA1aVa1Lys11eArgGIuLeu S e rAs pTy rL euL e u 40 GlriA.spTyrProValThrValAlaSerAsnLeuGln SEQ ：D NO： 604^ ^ PMCN32372.pep 45 Ai aAs nCys S er11eMe tileAs oGluIIelleHisHis LeuLysArg Pro ? roAs π Pro

LeuLsuAsp?roAsnA3r；LeuAsnSerGluAspMetAsplieLeuMecGiuArgAsnLeu Ar gT h r ? r o As n L e u L e u A1 a ? h e Va 1 Ar g A1 a Va 1L v s H i s L e uG 1 u A s nA 1 a 3 e r G1 y ILeGluAlalleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer ArgHis ?rollellellaLysAiaGlyAspTrpGlnGiuPheArgGiuLysLeuThr?he 50 TyrLeuVaiThrLeuGluGinAlaGlnGluGiriGlnTyrVaiGluGiyGiyGlyGiySer ?roG iyGluProSerG.ly Pro I leSerThr I leAsnProSer ?ro PrcSerLysGiuSer H i s L y 3 S e r ? r c A s η M e c A1 a A 3 p GI u G1 u L e u C y s G i y G1 y L e u T r p A r g L e u V a IL e u A1 aG 1 nAr gT r· p Me t G i li A r g L e u L y s T h rVa 1A i aG 1:/ S e r L 7 s Me t G i r.G 1 y L e u L e υ G L uAr gVa i As nT h r G1u11e H i s ? h eVa1T h r L γs Cy s A1a ? h eGIη P r o ? r o ? r c S e r 55 C y s L e u A r g P h e V’ a 1G1 η T h r A s η 工 1 e S e r A r g L e u L e u G1 n G i u T h r IS e r G i u G1 n L e u V a 1AI a L e u L y s ? r ο T r p 11 e T h r A r g G1 n A s n ? h e S e r A r g C y s L e u G1 u L e u G1 n C 7 s G1 η P r o As p S e r Se rT hr L e uG 1 yG i yG I y S e rG l yG I yG i yT hrG1 r.As cCy s S e r ? h e G1 nH i 3 ;5 e? r· ο I i e S e r S e r As p ? h· e A i d Va 1 Ly s I 丄 e Ar gG 1 u L e u S e r As pTy r L e u L a uG 1 η.λ3 oT v r P r o Va 1 Th r V ci IΛ1 a S e r As π L e uG i n SEQ ID NO :605 60 ' CMGN32373.pep A1 aAs nCy s Se r 11 eMe t: I ie As pG 1 u 11 e 11 eHi s H i s LeuLy sAr g ?ro Pro As n Pro 65 LeuLeuAs 〇 Pro.As nAs nLeuAs nSerG 1 uAspMe t:Asp 11 eLeuMe t:G I uArgAs nLeu A r g T h r ? r ο Λ s n L e u L e u ΛI a ? h e' / a IA r g Λ1 a V a i L y s K i s L e u G1 u A 5 nA 1 a S e r G L y 11eG1uA1aIi eLeuArgAsnLeuG LηProCy 3Leu?roSerAlaThrAlaAIaProSer ArgH13 Pro IlelieIieLvsAlaG LyAspTrpGInG1uPheArgGluLy3LeuThrPhe TyrLe'.iVdiThrLeuGLuGinAiciGiriGluGlriGLnTyrValGiuGLyGlyGLyGLySer 70 ?roCLy：：u?r〇berGLy?roIieSerThrIleAsnProSerProProSerLysGluSer H i s L//s S r c As r:M-22 As pG i uG l·] L此Cy sG1 yG W L θuT r p A r g Le^^ Λ Lad r. Λ r α T r c M e ^ G1 u Λ r g L e u L y 3 T h r V a IΛI a (Γ· lyS'arL· y 3 M e t G i n G1 y L e u L e u GluArq'；a iAsnThrG LulleH is PheVaLThrLysCysAi a?heGInProProPro5er 人n IG LnThrAsn I LeSerArgLeuLeuC inGiuThrSerG iuGinLeu 75 7 a i A i a L e u L y 3 P r: o 丁 r p I i e T h r A r g G i η Λ s n t? h .5 S e r A r g C y 3 L e u G 丄 u L e u G i r‘ C y s -225 -

O:\92\92747.DOC 200413407

GlnProAspSerSerThrLeuGiyGlyGlySerGlyGlyGlySerGlyGlyThrGinAsp CysSerPheGinHisSer?roIleSerSerAspPheAlaValLysIleArgGluLeuSer AspTyrLeuLeuGlnAspTyrProValThrValAiaSerAsnLeuGln SEQ ID NO ： 60»S PMON32374.pep AlaAsnCysSerlleMetlieAspGLuIielleHisHisLeuLysArgProPr〇AsnPro 10 LeuLeuAspProAsrLAsnLeuAsnSerGluAspMetAspIXeLeuMetGluArgAsnLeu A r gT h r P r o As n L eu L eu A1 a ? h e V a 1 Ar g A1 a V a 1 Ly 5 H i s L e uG 1 u As nA 1 a S e r G1 y IleGluAialieLeuArgAsnLeuGInProCysLeuProSerAlaThrAlaAiaProSer ArgHisProIlellelleLysAlaGlyAspTrpGlnGluPheArgGiuLysLeuThrPhe Ty r L e u V a 1T h r L euG 1 uG i aA I aG 1 nG 1 uG 1 nG I nTy r Va IG1 uG I y GI y GI y G1 y S e r i 5 ProGlyGluProSerGiyProlieSerThrlieAsnProSerProProSerL'/sGLuSei: HisLysSerProAsnMetAlaAspGiuGluLeuCysGiyGlyLeuTrpArgLeuValLeu GluArgValAsnThrGluIleKisPheValThrLysCysAlaPheGlnProProProSer Cy s L e uAr g ? he Va XGlnThrAsnlleSe r Ar g L euL e uG 1 r.G i uT h r S e rG I uG I r.L eu 20 ValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGiuLeuGinCys GlnProAspSerSerThrLeuGlyGlyGlySerGlyGiyGlySerGiyGlyGlySerGiy ThrG i nAs pC、/s Sei：?heGlnHisSer?rc)Ile S er S er As p P h eA 1 a'/a i Lys I i eAr g G1u L e u S e rAs pTyrL 8 uL euG1nAs pTyr ? ro VaIThrVa Ϊ A1a S e rAs nL euG1n SEQ ID ΝΟ：β0725 OMCN32375.pep AlaAsnCysSerIleMetlieAspGluIlelleHisHisLeuLysArgProProAsnPro 30

LeuLeuAspProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeu ArgThrProAsnLeuLeuAlaPheValArgAlaVaiLysHisLeuGluAsnAiaSerGly 35 40 45

IleGluAialieLeuArgAsnLeuGlaProCysLeuProSerAlaThrAlaAlaProSer Ar gK i s P r ο 11 e 11 e 11 e L vs A1 aG i yAs pT rpGI qG I u Ph eAr gG 1 uLy s Le uT h r Phe T y r L e u Va IT h r L e uG 1 uG I nA 1 aG 1 aG i uG I nG I n.T y r V a 1G1 uG 1 y G1 yG1 yG1 y S e r ?roGlyGlii?roSerGlyProIleSerThrIleAsnProSer?ro?roSerLysGiuSer HisLysSerProAsriMetAiaAspGluGiuLeuCysGlyGlyLeuTrpArgLeuValLeu AlaGIrJVrgTrpMetGluArgLeuLysThrValAlaGIySerLysMecGinGlyLeuLeu GluArg'/aiAsnThrGluIleHisPhe'/alT'hrLysCysAlapileGinProProiProSer CysLeuArgPheVaiGlnThrAsnlleSerArgLeuLeuGlnGiuThrSerGluGinLeu ValAlaLeuLys ProTrpIleThrArgGinAsnPheSerArgCysLeuGiuLeuGInCys GlnProAspSerSerThrLeuGlyGlyGiySerGlyGlyGlySerGlyGlyGlySerGiy GlyGlyThrGlnAspCysSerPheGlnHisSerProlieSerSerAspPheAlaValLys IleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAiaSerAsnLeu Gin SEQ ID MO :608 pM〇N32375-pep A1 aAs nCys Ser· I： leMe 匚 I i eAspG 1 u I i e 工 1 el·: i s H i s LeuLys Ar g Prc As n Pro 50 L e u L e u A s p ? r o As nAs nL eu As n S e r G i u As p Me t As p 110 L e uMe t GI uA r g A s r,L e u A r g T h r ? r o A s n L e u _L 3 u A ! a ? h e'/ a 1 r .g A1 a V a i Ls K i s L <2 u G ! u A s nA LaSerGl'/ IleGluAialle L eu Ar gAs nL euG i ρ· P r oCy s L eu P r o S e ιτΛΐ aT hr A1 aA i a ? r c S e i: Ar gH 1 eLys AiaG 丄 yAs p.TrpC七G1 u PheArgG i uLy s L6：uThr ?he T y r L e u Va 1T h r L e uG i uG I nA I aG 1 nG 1 uG 1 nG i nTy r Va IG i uG 1 yG i yG 1 y G1 y S e r H i s Ly “ Ser ?r ◦ As oHe t A iaAs pG iuG luLeuC'/sG i，/G i yLeuTrpAr gLeuVa i Leu A1 aG i nA r gT:: p He 匕 G i u Ar g L e u L y s T h r Va i A ；L aG 1 y S e r: Ly s W e tiG 1 nG i y L e u L e u GiuArgVaiAsn.Th‘rG1 u工 ieHisPheV，aiThr二ysCysAlaPheGinPr〇?ro?i：〇Ser Cy s LeuAr a ?he Va i G1 nThr As η 11 eS e r Ar g Leu LeuG i r；G 1 uThr S e rG i uG 1 nLeu 60 Va1A1aLe uLy 3 ? r οT rp11eThrArgΰInAs η Phe S e rAr gCy s LeuG i u Le uG1nCy s GlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGIyGIySerGly G1 y G L y S e r G iyG 1 yG JL y S e rG i '/ThrG nAspCy 3 Ser?heGinHisSerProIleSer SerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGIrL^spTyrProVal ThrValAIaS-erAsnLeuGln SEQ ID MO :609 65 pMON3：3 73. cep

AiaAsr.CysSerlieMet :ieAspGLdIieneHisHii3LeuLysArgPr：oP2roAsn?ro 70 L^uLeuAspPrroAsnAsnLeuAsnSerGluAscMecAspI LeLeuHeCGLuArgAsnLeu A r gT h ϊ* P it o A*s n L« e u L e u A 丄占 P h eV A1A it g A i 戈 7.¾ ]_ l y s H l s i_· e uC； 1 uA s r· A1 a S e rG i y 11 e G l u Λ i a I L e L e u A r g A s n L e u G1 n ? r 〇 C y 3 L e u ? r o S e r A1 a T h r Λ1 a ΛI a ? r 〇 S e r Λ r α H i 3 ? r ο I L e 11 e 11 e L y s A i a G1 y A s p T r p G1 n G i u P h e A r g G i u L y 3 L e u T h r P h e T v !： Le uVa LTh r IeuG i uG !· r\A i aG i nG L uG i nd nTyrVva id uG i '/G i '/G iyG 1 '/S*er 75 ?roGivG Lu?roSerGlyPr〇-Ie5erT^-IleAsnProSerProProSerLysGluSer

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HisLysSer ProA〇nMetAIaSerLysMet:GlnGlyL0uLeuGluArcjVaiA3nThrGiu IIsHisPheValThrLysCysAiaPheGinProProProSerCysLeuArgPheVciiGlri Thr Asnl ieSer ArgLeuLeuGinGluThrSerGluGlnLeLiValAlaLeuL./s ProTrp IleThrArgGlnAsnPneSerArgCys LeuG LuLeuGInCysGinProAspSerSerThr 5 LeuGIyGlyGiySerGlyGlyThrGiriAspCysSerPheGlnHisSerProlleSerSer As p ? heAIaVaILys11eArgGIu Le u S e rAs pTyrLeuL euG1nAs pTyr ProValThr Va 1A1 a 3 e r A.s n L e uG 1 oAs pG i uG 1 u L e uC ysG I yG 1 y L e uT rpAr g L eu Va i L eu A1 a GlnArgTrpMecGIuArgLeuLysThrVaiAlaGiy SEQ ID MO：610

iO pMON3 2 3 7 9. pep ΛΙaAs aCys S e r11eMe c11eAs pGIu11e11eH i s H i s LeuLy3 Arg P ro ? ro As n Pro LeuLeuAsp ?roAs oAs nLeuAs nSerG1uAspMe CAspIleLeuMe tG iuArgAs nLeu 15 ArgThrProAsnLieuLeuAiaPheValArgAlaValljysHisLeuGiuAsnAlaSerGiy IleGluAialleLeuArgAsnLeuGinProCysLeuProSerAiaThrAlaAlaProSer ArgHis ?roIleilelleL'/sAiaGlyAspTrpGlnG LuPheArgGluLysLeuThrPhe Ty r L e uVra 1T h r L e uG 1 uG i nA 1 a G1 nG 1 uG 1 nG i nTy:: Va 1G1 uG 1 yG 1 yG 1 yG i y S e r ProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysG LuSer 工ieHis?heValThrLysCysAia?iieGlnPr〇Pr3ProSerCysLeuArg?heValGln

IleThrArgGlnAsnPheSerArgCysLeuGiuLeuGInCysGlnProAspSerSerThr LeuGlyGlyGlySerGlyGlyGlYThrCinAspCysSerPheGlnHisSerProlieSer 25 SerAspPheAlaValLvsIleArgGiuLeuSerAspTyrLeuLeuGlnAspTyrProVal

ThrValAlaSerAsnLeuGlrLAspGluGluLeuCysGlyGl'/LeuTrpArgLeuV’alLeu AiaGl^rgTrcMetGiuArgLeuLysThrValAiaGly SEQ ID NO： 611 30 pMON3 2 3 3 0. pep aAs nCy s S r* I i eMe c 11 eAspG 1 u 11 e 11 eH i s H i s L euLy s Ar g Pro c As η P r ◦ LeuLeuAspProAsnAsnLeuAsnSerGiuAspMecAs? ΓleLeuHetGiuArgAsnLeu ” Ar gT h r ? r o As a L eu L e uA i a ? h 8 Va i Ar g A1 a Va i Ly 3 H i s L e uG I u As nA 1 a S e r G1 y 35 IleGluAialleLeaArgAsnLeuGInProCysLeuProSerAiaThrAlaAlaProSer

ArgHis Pro IleileileLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe Tyr L e uVa i Th r L euG1uG1nA1aG1nG1uG1nG1nTyrVa1GIuG1yG1yGIyGlySer ProGlyGlu?roSerGly?roIleSerThrIIeAsnProSerPro?roSerLysGluSer H i s L y s S e r P r o A s nM e t A1 a S e r L y s M e c G1 n G1 y L e u L e u G1 u A r g V a IΛ s η T h r G i u 40 11 eH i s Phe Va IThrLy sCy s A i a ?heG In ProPiroProSerCysLeuArgPhe'/aLG in

ThrAsnlleSerArgLeuLeuGinGiuThrSerGiuGlnLeuValAlaLeuLys ProTrp IleThrArgGirL^snPheSerArgCysLeuGluLeuGinCysGlnProAspSerSerThr L e uG I y GI y GI y S e r GI y G1 y G1 y S e r G i y GI yT h r GI nAs p Cy s S e r ? h eG i ηK i 3 S e r ^ Pro I丄eSerSerAspPheAlaVaiLysIleArgGluLeuSerAspTyrLeuLeuGlnAsp 45 Tyr ?ro-/aiThrVa1AlaSsrAs nLeuGInAspG1uGIuLeuCysGIyGlyLeuTrpArg L e u V a 1L e u AI a G i r g T r d M e t GI u A r g L e u L v s T h r V a 1AI a G1 vr SEQ ID MO：6 i 2 ^ ^ -

50 pMOM32331.pep a As nCy s S e r I： i eMe t 二 i pG i ’u 工 1 e I i eh·: i s M i s LeuLy s Ar g ? r c ? !：◦ As η P r o L e u L e u A s p ? r o A s n A 3 n L e u A s n S e r GI u A s p M e c Λ 3 p 11 e L e u M e c GI u A r g A s n L e u Ar gT h r P r ο Λ 3 n L e u L e u AI a ?h e -/a 1 Ar g A1 a V a I Ly s H i s L e uG 1 u As π-η I a S e r G1 y 55 I leGiuAia二 leLeuArgAsnLeuG AlaA丄a?rcSer A r g H 二 s ? r ϋ e 二 1 e I： i e L y s A i aG 1 y As ρΊ1 r pG 1 nG i 'j ? h e A r gG i u Ly s L e uT h r ? h e T y r L e u Va _ T h r L e uG 1 uG I n AI aG 1 nG i uG i r.G 1 nTy r V a 1G i uG 1 y GI yG I yG lySer ?roGiyGlu?ro:5erC；ly ?::〇工 leSerT’nr I leAsn?r.3Ser ProProSerLysG luSer H i s L γ s S e r· P:: o As nMe t A i «a :3 e 2： Ly s Me t:G 1 nG i y L eu L e uG 1 uArg iAs nThr^G 1 u 60 IleHis PheVaIThrLysCysAlaPheGinProProProSerCysLeuArgPheValGln

ThrAsnlleSerArgLeuLeuGlnGluThrSerGluGlnLeuVaiAiaLeuLys ProTrp IleThr ArqGlnAsnPheSerArgCysLe'jGiuLeuGlnCysGInProAspSerSerThr L e u G1 y G1 y G1 y S e r G i y G1 yG I y S e r G1 y G1 y G1 y S e r GI y T h r G i aAs pCysSerPhe GI η H i 3 S e r P r ο I i e 3 e r S e r As p ? h e A1 a Va 1 Ly 3 11 eAr gG I u L e u S e r As pT y r L e a 65 LeuG 1 nAs pTy r ? r o Va iT hr Va i A i aSe r As nLeuG I r^A3 pG 1 uG 1 u LeuCy sG i yG I y L e u T r p A r g L e u Vr a IL e u A i a G i r. A r g T r p M e t: G1 u Λ r g L e u L y s T h r V a 1A1 a G i y SEQ ID MO：6 1 3 70 pMOM3： . cep Λ i a As r.C y s S e r 11 eMe c ： 1 As pG 1 u 11 e 11 e H i s H i s Leu Ly 〇 Arg Pro P r o As n ? r o LeuLeuAsp ?::〇AsnAsnLeuAsnSerG LuAspMecAsp C leLeuMetGJ-uAr.gAsnLc'u Λ r ςΊ1 h r P r r Λ s n L e u L e u A1 a ? h e Va 1 Ar i a Va 1L y s H i s L euG 1 uAs nA 1 a S e rG I y 75 Γ ieG HeLeuArgAsnLeuuinProO/sLeuPiroSeirAliiThirAlaAlaPiroSei:

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ArgHisPrcIlelleileLysAlaGl'/AspTrpGinGLuPheArgGLuLysLeuThrPhe TyrLeuValThrLeuGiuGin.MaGInGLuGinGixnTyrVaiGluGlyGlyGiyGlySer ProGl'/GluProSerGiy ProIIeSerThr I LeAsnProSer ProProSerLysGluSer HisL'/sS"er?rcAsriMet:AiaSerLysMet:GlnGly[^uLeuGluArgValAsnThrGiu 5 I leHis?heV，a lThrLysCys AiaPheGlnPrro Pro PrcSerCysLeuArgPheVa 丄 Gin

ThrAsnlleSerArgLeuLeuGlnGluThrSerGluGlaLeuValAlaLeuLysProTrp IleThrArgGlr\Asn?heSerArgCysL.euGluLeuGLnCy3GlnProAspSerSerThr LeuGlyGlyGiySerGiyGIyGlySerGlyGiyGiySerGlyGlyGlyThrGlr^spCys SerPheGinHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAsp 10 TyrLeuLeuGlnAspTyrProVaiThrValAiaSerAsnLeuGinAspGluGluLeuCys GiyGlyLeuTrpArgLeuVaiLeuAldGlnArgTrpMecGluArgLeuLysThrValAla Gly SEQ ：D MO :614 15 OM0N3 23 3 3. pep

AlaAsnCysSerlieMetILeAspGluIlei1eHisHisLeuLysArgProProAsnPro LeuLeuAspProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeu ArgThr ?roAs nLeuLe uA i a ? heVaIArgAi aVa1LysH i s LeuG i uAs nA1a S e rGIy 20 IleGluAlalIeLeuArgAsnLeuGlnProCysLeuPro5erAlaThrAlaAIa?roSer Ar g H： i 3 P r ο I i e 工 1 e 11 e Ly s A i aG i y As p.T r pG i nG i u P he Ar gG 1 uLy s L euT hr ? he TyrLeuValThrLeuGIuGInAlaGIriGluGInGInTyrVaiGluGlyGlyGlyGlySer ProGIyGIuProSerGlyProIieSerThrlLeAsnProSerProProSerLysGluSer H i s Ly s S e r P r o As nMe C A1 a S e r Ly s Me cG I r.G 1 y L euLeuG 1 uAr g Va 1 As nThrG 1 u 25 IleHis?heVaiThrLysCysAla?heGIn?roPro?roSerCysLeui\rg?heVaIGln ThrAsnlieSerArgLeuLeuGlnGluThrSerGluGir.LeuValAlaLeuLysProTrp IleThrArgGIriAsnPheSerArgCysLeuGiuLeuGlnCysGlnProAspSerSerThr LeuGlyGiyGlySerGlyGiyGlySerGlyGiyGlySerGlyGlyGIySerGlyGlyGly S e rG1yT hrG1nAs pCys S e r Ph eG1nH i s S e r Prο11e S e r S e rAs p ? heAIaVa1Lys 30 IIeArgGluLeuSerAspTyrLeuLeuGInAspTyrProValThrVaIAlaSerAsnLeu G1 nAs pG L uG 1 u L e uCy 3 G1 yG 1 y L e uT r p Ar g L eu Va 1L eiJL\ 1 aG 1 nAr gT r pMe cG i u ArgLeuLysThrVaiAlaGly SEQ ID NO：615 35 pMCN3 2 3 3 4. pep A1 aA s nC y sSerlleM et 工 le A spGlu I IsIleHisHisLeuLysArgPro?!：：) As n Pro L e u LeuAs p Pr o As nAs nL· e uAs nS e rG1 uAs pMe t Asp 11 eL euMe cG 1 uAr gAs n^e u Ar gT h r P r o As nL euL e u A1 a ? h e Va 1 Ar g A1 a Va 1 Ly s H i 3 L e uG I u As rJ\i a S e r G i y 40 IleGIuAialleLeuArgAsnLeuGInProCysLeuProSerAlaThrAlaAiaProSer ArgHisProIlellelleLysAlaGlyAspTrpGlnGiuPheArgGiuLysLeuThrPhe Ty r L e u'/a IThrLeuGi uG 1 nA 1 aG 1 nG i uG 1 nG 1 nTyrVa 1G1 uG 1 yG i ’/G 1 yG 1 :/S e r ?r〇GlyCUroSerGlyProI ieSerThr 工 leAsn?rcSer?ro?roSerLysGluSer HisLysSerProAsnMecAlaProPiroSerCysrjeuAirgPheV’aiGlnThrAsrilieSer 45 ArgLeuL euG1nGIuT hr S e rG1uGInLeuVa iA1aL eu Ly s ? roT rp11eThrArgG1n

As n ?h e S e r Ar gCys L e uG1uL e uG1nCysG1ηPr oAs p S e r S e rThr Le uGIyG1yG1y SerGlyGiyThrGlnAspCysSerPheGInHisSerProIleSerSerAspPheAlaVal Lys I leArgGIuLeuSer Asp'TyrLeuLeuGipjAspTyr ProVaiThrVa iAiaSer Asa L e u G1 pJ-. s p GI u G i u L e u C y 3 G i y G1 y L e u T r p A r g L e u V a 1L e u A i a G1 r. Λ r g T r p M e t 50 G J- u Ar g L e u L y s 'Γ h ir'/a 1A1 aG 1 y S e r 1^/ s Me 匕 G1 nG 1 y L e u L< e uG 丄 u Ar g Vra 1 As nT h r Giu：leHi3?heValThrLy3CysAia?heGin?ro SEQ 二3 NO：516 ΌΜΟΜ3 23 3 5.oeo 55 ' A i a As nC，_/ s S r I i eMe c 11 e As pG 1 u 11 e 工 e H i s H i s L e ti Ly s Ar g P:: 3 ?o As n ? r o L e u L e u A s p ? r ο Λ s nA s n L e u A s n S e r: G1 u A s p M e t A 〇 p 11 e L e u M e t G1 j. A r g A s n L e u Ar gT a r ? r o A s n L e υ L e u A1 a ? h e Va 1 Ar g AI a Va 1L y s K i s L e uG I u As nA I a S e r GI y 11eGIuA i aIi e LeuArgA〇 nLeuG1n Pr oCys L eu P r o S e rAIaThrA1aA i a P rc S e r 60 ArgHisProIielielieLysAlaGlyAspTrpGlnGluPheArgGiuLysLeuThrPhe TyrLeuVaiThrLeuGiuGInAlaGinGluGInGinTyrValGluGlyGlyGlyGlySer ProGLyG LuPrroSerGiy Prol leSerThirl LeA.snPrroSeirProPrQSeirLysGlLiSe]： H i 3 Ly 5 S er ? r o As nMe t: A1 a ? ro ? r o S e r Cy s Le uAr g PheVa 1GI nTh r As η 11 e S er Λ r g L e u L e u G i r. G1 u T h r S e r ΰ 1 u G1 n L e u V* a 1AI a L e u L· y s P r ο T r p 11 e T h r A r g G1 n 65 AsaPheSerArgCysLeuGIuLeuGlnCyoGlnPrcAspSerSerThrLeuGlyGlyGly S e rG i yG i yG i yThrG L nAs pCy s S e i: ?heG i r‘H i 3 S e r E5 r ο I i e S e r S e r As p Phe A i a ValL，./s i： leArgG luLeuSerAs pTyirLeuLeuG InAspTyr ProValThrVal A Laser" .二·snLeuGh'spGluGluLeLiCysGlyGlyLeuTrpArgLeuValLeuAldGinArgTrp Me cd L uAr g uL'/sThrVa i A i aG i，/Se::Ly s Me cG 1 nG 丄 yLeuLeuG 1 uAr gVa i As n 70 ThrGl'jl ieHis PheVa IThrLysCysAlaPhaGlnPro SEQ ID MO :617 PMON3 23 36. cep 228-

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AlaAsnCysSerlleMetlleAspGluIlelleHisHisLeuLysArgProProAsnPro IieuLeuAspPiroAsriAsnLeuAsnSerGluAspMe tAspI leLeuMetGiuPLrgAsnLeu ArgThrProAsnLeuLeuAlaPheValArgAlaValLysHisLeuGluAsnAlaSerGly IleGluAlalleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer 5 ArgHisProIlellelleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer P:c〇GlyGluPi:〇Se:rGlyProIleS*2：i:Thi:Il<2AsnP2roSorPi：o?;r〇Sei:L；ysGluS*e2： HisLysSerProAsnMetAlaProProSerCysLeuArgPheValGlnThrAsnlleSer ArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGln 10 AsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGly SerG 1 yGlyG 1 ySerG lyGlyThrG InAspCysSerPheGlnHisSer Pro I lewder Ser AspPheAlaVaiLysIleArgGluLeuSerAspTvrLeuLeuGlnAspTyrProValThr ValAlaSerAsnLeuGinAspGluGluLeuCysGlyGlyLeuTrpArgLeu'/alLeuAla GlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGiyLeuLeuGlu 15 ArgValAsnThrGluIleHisPheValThrLvsCysAlaPheGlnPro 3EQ ID NO:618 ^ ΌΜΟΝ3 2 3 87.Oep 20 ΑΐαΑ3ηΟ：/3 3θΓΐ1θΜθΙ:Ι：ΐ0Α3ρΟ1\·ΐΙΐ0ΐ1βΗΐ5Ηί5ΐ^θΐιΙ^γ3ΑΓ9?::οΡΓ〇Α5ηΡΓ〇

LeuLeuAspProAsnAsnljeuAsnSerGluAspMe tAspI leLeuMe cGlaArgAsnljeu ArgThrProAsnLeuLeuAlaPheValArgAlaValLysHisLeuGluAsnAlaSerGly IleGluAlalleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAiaAlaProSer 25 ArgHisProIlellelleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe TyrLeuValThrLeuGluGlnAiaGlnGluGlnGlnTyrValGluGlyGlyGlyGiySer ProGlyGluProSerGlyProIleSerThr工leAsnProSerProProSerLysGluSer HisLysSerProAsnMetAlaProProSerCysLeuArgPheValGlnThrAsnlleSer ArgLeuLeuGlnGluThrSerGluGlnLeuVaiAlaLeuLysProTrpIleThrArgGlrL 30 AsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGly SerGlyGlyGlvSerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerPro IleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyr ProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeu ValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGly 35 LeuLeuGluArgValAsnThrGluIleHispiieValThrLysCysAlapFieGlnPrc) SEQ ID MO :619 pMON32383.oep 40 ‘

AlaAsnCysSerlleMetHleAspGluIlelleHisHisLeuLysArgProPrQAsnPro LeuLeuAspProAsnAsnLeuAsnSerGiuAspMetAspIieLeuMetGluArgAsnLeu ArgThrProAsnLeuLeuAJLaPheValArgAlaValLysHisLeuGluAsnAlaSerGly 工leGluAlalleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer 45 ArgHisProIlellelleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe TyrLeuValThrLeuGluGlnAlaGlnGiuGlnGlnTyrValGluGlyGlyGlyGlySer ProGlyGluProSerGlyProIleSerThrlleAsnProSerProProSerLysGluSer HisLysSerProAsnMetAlaProProSerCysLeuArgPheValGlnThrAsnlleSer ArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGln 50 AsnPheSerArgCysLeuGluLeuGiuiCysGlnProAspSerSerThrLeuGlyGlyGly SerGlyGlyGlySerGlyGlyGlySerGlyGlyGlyThrGinAspCysSerPheGlnKis SerProIIeSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGln AspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGiyGlyLeuTrp ArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMet 55 GlnGlyLeuLeuGluArgValAsnThrGiuIleHisPheValThrLysCysAlaPheGln Pro SEQ ID MO :620 PMON32339.pep 60

AlaAsnCysSerlleMetlleAspGluIlelleHisHisLeuLysArgProProAsnPro LeuLeuAspProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluAr'giXsnLeu ArgThrProAsnLeuLeuAlaPheValArgAlaValLysHisLeuGluAsnAlaSerGly IleGluAlalleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer 65 ArgHisProIlellelleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe TyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer ProGlyGluProSerGl'/ProIleSerThrlleAsnProSerProProSerLysGluSer HisLysSerPrcAsnMetAlaProProSerCysLeuArgPheValGlnThrAsnlleSer ArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGln 70 AsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGly SerGiyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyThrGln AspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGloLeu SerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGlu LeuCysGlyGlvLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThr O:\92\92747.DOC -229- 200413407

Va 1A i aG 1，/S erL ./s Me tG 1 nG JL y LeuLeuG 1 u ArgVa iAs nThrG 1 u I 丄 e H i s Phe 1 ThrLy3Cy〇A1aPheGIηPro SSQ ID MO :621 5 hflt3-23291inkl0.pep

AlaAs nCys S d i eMe 亡11eAs pGiuIlelleHisHis LeuLysArg P ro ProAs η P ro LeuLeuAspProA3n.AsnLeuAsnSerGluAspMetAspIieLeuMet:GluArgAsnLeu ArgThrProAsnLeuLeuAldPheValArgAlaValLysHisLeuGluAsnAlaSerGly 10 IleGluAlaIleLeuArgAsnLeuGlnPr〇CysLeu?roSerAlaThrAlaAlaProSer ArgHisProIiellelieLysAlaGlyAspTrpGlnGiuPheArgGIuLysLeuThrPhe iy^'i-i^uVcilTh.z' L euG i uu i πΑ 1 dG 1 nG 1 uG 1 nG lnTyrV<3.1GI uu 1 yG 1 yG 1 yG 1 y Ssir ProGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGIuSer HisLysSerPi:oAsaMe!：AlaAspTyrPr*〇V，arThi:ValAla_Se:r:AsnIjeuGlnAspGlu 15 GluLeuCysGlyGiYLeuTrpArgLeuVaiLeuAlaGlnArgTrpMetGIuArgLeuLys ThrValAlaGiySerL^/sMeCGlnGlyLeuLeuGluArgV’alAsnThrGluIleHisPhe ValThrLysCysAla?fieGln?ro?roProSerCysLeuArgPheValGlr‘ThrAsnI le SerArgLeiiLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIIeThrArg GlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGly 20 GlySerGlyGlyGiySerGlyGlyThrGlnAspCysSerPheGlnHisSerProXieSer SerAspPheAlaValLvsIleArgGIuLeuSerAspTyrLeuLeuGln SSQ ID NO：622 "

25 hf Ii:3-23291inkl5 .pep A1aAs nCys SerlleMetlleAs pGluIieIieHisHisLeuLysArg?ro?roAsn?ro ^ ArgThr ? r oAs nL euLeuAIa ? heVa1ArgA1aVa1Lys H i s L euG1uAs nA i a S erG i y 30 11 eG 1 u A1 a 11 e L e u Ar g As n L e uG 1 η P r 〇 C y s L e u P r 〇 S e r A i aT h r A i a A i a P r o S e r

ArgHisProIi-ellelleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe Ty r Le u Va 1Thr L e uG 1 uG 1 nA 1 aG 1 nG I uG 1 nG i nTy r Va 1G1 uG 1 y G1 yG 1 yG1 y S e r ProGlyGIuProSerGIyProIIeSerThrlleAsnPrcSerProProSerLysGluSer ^ H i s Ly s 3 e r P r o As n£4e c A1 a As ?Ty r P r o Va i T hr Va i AI a S e r As nL euG 1 p.As pG 1 u 35 GluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMeCGluArgLeuLys ThrVaiAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGiuIieHisPhe ValThrLysCysAIa?heGln?ro?ro?roSerCysLeuArgPheValGinThrAsnIie SerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysPrcTrp 工 leTDrg G1 nAs η Ph e S erArgCys LeuG1uLeuG i nCysG1η ? roAs p S e rSerThr Le uG1yG i y 40 GlySerGlyGlyGlySerGlyGlyGlySerGlyGiyGlyThrGlnAspCysSerPheGin HisSerProIleSerSerAspPheAlaValLyslIeArgGluLeuSerAsOTyrLeuLeu Gin SEQ ID NO：523 45 hflt.3-34351inki0.pep Λ1aAs nCys S e r11eMe tileAs pGluIlelleHisHis LeuLvs Ar g Pro ?r cAsnPr o LeuLeuAspProAsp一二.snLeuAsnSerGluAs?Met:AspIleLeuMetGluArgAsnLeu _ ArgThr P r o As nLeuLeuA 1 a ?heVa 1 Arg A ld\/a i Ly s H i s LeuGl uAs nAl aSerG i y

50 I leGiuAlalleLeuArgAsnLeuGinPircCysLeuPiroSerAiaThrAlaAlcaPrcSer ArgHisPrroIiell elleLys A1 aG lyAs pT rpG 1 nG 1 u PheArgG 1 u LLe u.Th r P he TyrLeuValThrLeuGiuGir^iaGlnGluGinClnTyrValGIuGIyGiyGiyGiySer ProGlyGiuProSerGlyProIieSerThrIieAsnProSerProProSerLysGluSer _ _ H i s L y s S e r ? r o A 3 α M e t A L a A1 a. S e r Λ s π L e u G i n A s p GI G1 u L e u C y s G1 y (31 y L e u 55 T rpAr g L euVaILeuA i aGI ru\rgT rpMe cG1uAr g L e uLysThrVa iAIaGIyS e rLys M.etGlnGlyLeuLeuGluArgVaiAsaThrGiuIieHisPheValThrLysCysAiaPhe GlnPro Pro ProSe rCys LeuArg Pheva IG Ir.ThrAsn I i eSer ArgLeuLeuG Ir.G iu T h r S e r G1 uG i n L e u Va IΛ1 a L e u L y s P r oT r p 11 eT h r A r gG I pJ\s η P h e S e r Ar gCy s L e uG 1 u L e uG I nCy 3 G1 n ? r o As p S e r S e r Th r L e uG 1 yG 1 yG 1 y S e rG i yG I yG i y S e r 60 G iyGlyThrGInAspCys Ser PheGInHis Ser ?roIleSerSerAsp PheAlaValLys Γ1eArgG1uLeu S e rAs oTyr LeuLeuGInAs pTyr P r oVaIT hrVa1 SSQ ID NO :624 " 65 hf lc3 -,M351inkl5 .pep Λ1aAs nCys S e r11eMe 111eAs pG1u11eIi eH i s H i s LeuLysArg P ro ProAs n Pro LeuLeuAspPiroAsnAsnLeuAsiiSeirGiuAspWecAsplieLeuMetGiuAirgAsnLeu Λ r g T h r P r o A 5 n L e u L e u Λ1 a ? h e V a 1A r g A1 a V a 1L y s H i 3 L e u GI u A s n A1 a S e r G1 y 70 11 e G1 u A i a 11 e L e u A r g Λ 3 n L e ii G1 η P r o C y s L e u ? r o S e r Λ1 a T h r A1 a AI a P r o S e r

ArgHij Pro :丄e I iel [•eL'/sAiaGi’/Asprrr'pGlnGluPheAr'gGluLysLeuThrPhe TyrLeuVarrhrLeuGiuGinAldGlnGiuGlnGinTyrValGluGlyGlyGlyGlySer ProG LyGiuProSerGly?roIleSerThrIIeAsn?roSerProProSerLysGluSer ^ H i 3 L V 3 S e r P r v〇 A 5 p.M e C A i a Λ i a S e r A s n L e uC i s pG 1 uG 1 u L e uC y s G1 yG 1 y Leu 75 TrpArgLeuValLeuAlaGinArqTrpMecGIuArgLeuLv^sThrValAlaGiySerLys O:\92\92747.DOC -230 - 200413407

MetGInG LyLeuLeuGluArgValAsnThrGiuIieHis PheValThrLysCysAlaPhe GlnProProProSerCysLeuArgPheValGinThrAsnlieSerArgLeuLeuGlnGlu ThrSerGiuGlnLeuValAiaLeuLysProTrpIleThrArgGlnAsnPheSerArgCys LeuGIuLeuGlnCysGInProAspSerSerThrLeuG 1：/G IvGlySerGIyG LyGlySer GlyGLyGlySerGlyGlyGlyThrGlnAspCysSerPheGlnHisSerProlieSerSer AspPheAlaVaiLysIleArgGluLeuSerAspTyrLeuLeuGlaAspTyrProValThr Val 3EQ ID NO :62 5 10 hflt:3-6263iinkI0.pep

AiaAsnCysSerlleMetlleAspGluIielieHisHisLeuLysAirgProProAsnPro LeuLeuAspProA〇nAsnLeuAsnSerGluAspMetAspIieLeuMetGluArgAsnLeu ArgThrProAsnLeuLeuAlaPheValArgAiaValLysHisLeuGluAsnAlaSerGiy 15 IleGiuAlaIleLeuArgAsnLeuGLnProCysLeuProSerAlaThrAldAiaProSer

ArgHis ProliellelleLysAlaGlyAspTrpGinGiuPheArgGluLysLeuThrPhe Ty r L e uVa IT h r L e uG 1 uG i n.\l aG I r.G i uG I r,G i nTy r Va 1G1 uG 1 yG 1 y G1 y G1 y S e r PiroGLyGluPtroSeirGlyPiroI leSerThr 二 leAsnProSerProPiroSeirLysGluSer· HisLysSer ProAsaLMetAiaVaiAIaGiySerLysMecGinGl'/LauLeuGiuArgVal 20 AsnThrGluIleHisPheValThrLysCysAiaPheGlnProProProSerCysLeuArg PheValGlnThrAsnlleSerArgLeuLeuGlnGluThrSerGluGlnLeuVaiAlaLeu LysProTrpIIeThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGinProAsp SerSerThrLeuGlyGiyGlySerGlyGlyGlySerGl^/GiyThrGlrLAspCysSerPhe GlnHisSerPro 工 LeSerSerAspPheAlaValLys IleArgGluLeuSeirAspTyr'Leu 25 LeuGin.^spTyr?roValThrVaiAiaSerAsnLeuGlnAspGluGluLeuCysGiyGly LeuTrpArgLeuValLeuAlaGlnArgTrpMetGIuArgLeuLysThr SEQ ID NO：625 30 hfit:3-62531inlcl5 .pep A1 a As nC y s S e r 1e Me c 11 eAspG luIlelleH is His L euLysAr gPro?ro As n Pro LeuLeuAspProAsnAsnLeuAsnSerGiuAspMstAspIieLeuMetGluArgAsnLeu ArgThr?roAsnLeuLeuAla?heValArgAlaVaiLysHisLeuGluAsnAlaSerGly 35 IleGluAlalLeLeuArgAsnijeuGinProCysLeuPiroSerAlaThrAlaAlaPr'oSer· ArgHisPro lielieIleLysAlaGlyAspTrpGInGiuPheArgGluLysLeuThrPhe TyrLeuValThrLeuGluGir^laGInGIuGlr.GlnTyrValGluGlyGIyGiyGlySer ProG 1 yG lu Pr〇S erG ly Pro I leSerThr I leAsnProSerPircDProSerLysGluSei： His Lys Ser ProAsnMe cAlaValAiaGlySerLysMetGInGlyLeuLeuGluArgVal 40 AsnThrGiuIleHis PheValThrLysCysAlaPheGinProProProSerCysLeuArg PheValGInThrAsnlleSerArgLeuLeuGinGIuThrSerGIuGlnLeuValAlaLeu Lys ProTrpIleThrArgGlr^snPheSerArgCysLeuGluLeuGinCysGlnProAsp SerSerThrLeuGlyGlyGlySerGiyGIyGiySerGlyGiyGlySerGiyGiyGlyThr G1 nAs pCy s S e r Ph eG 1 nH i s S er ? r o 工 1 e S er S er As p PheAl aVa 1 Lys 工 1 eArgG 1，j 45 LeuSerAspTyrLeuLeuGlnAspTyrProVaiThrValAlaSerAsnLeuGInAspGlu GluLeuCysGlyG LyLeuTrpArgLeuVaiLeuAlaGlriArgTrpMetGiuArgLeuLvs Thr SEQ" ID NO：β27 ^ 50 -949 5 iinkiO . pep Λ

AlaAs nCy s S e 2： I i eMe c 11 eAs pG lu I i e 工 1 i s H i s LeuLy s Ar g P it o Pro As η P r〇 LeuLeuAs p ?r oAs nAs nLeuAsnSerG 1 -^spMe cAsp 11 eLeuMe tG 1 uArgAsnLeu ArgThr ProAsnLeuLeuAlaPheValArgAiaVaiLysKisLeuGluAsn^.IaSerGly 55 IleGluAlalieLeuArgAsnLeuGInProCysLeuProSerAlaThrAiaAldProSer Ar'gHis Pro I ide I ieLysAlaGlyAspTrpGlnGiuPheArgGiuLysLeuThr Phe Ty r L e u Va i T h r Le uG 1 uG 1 nA I aG i nG I uG 1 aG 1 nTy r Va i G i uG I yG1 yG 1 y G iy S e r PrcGLyGLuProSerGiy?ro工leSerThrILeAsnProSerProProSerLysGluSer His L./s Ser ?ro AsnMe tAlaArg?he'/alG InThrAsriI ieSerAirgLeuLeuGlnGlu 60 ThrSerGIuGlnLeuValAlaLeuLysProTrpI leThrArgGlnAsnPheSerArgCys LeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySer G1 yG 1 y T h r G1 pJ^*s pCysSerPheGlr.HisSerProIieSerSerAspPheAlaValLys IleArgG luLeuSerAspTyrLeuLeuGinAspTyrProVaiThrValAlaSerAsnLeu G1 nAs pG 1uG1u L euCy sG1yGIv LeuT rpArg L euva1LeuA1aGInArgT rpMe tG1u 65 ArgLeuLy sThrVa lAiaG iySerLysMetG InG LyLeuLeuG iuArgVa LAsnThrGlu 11eK is ?haValThrLysCysΛ1aPheGIn?roPrc?ro5erCysLeu SEQ ID MO：623 70 h π 113 - ί/ 4 9 S 1 i:iki 5 . pep Λ丄dAsnC\/3：5t2r I leMec 二 ieAspGiLiI： iel leHisHisLeuLysArgProProAsnPiro LeuLeuAsp ProAsnAsnLeuAsnSeirG i.jAspMecAspΓieLeuMetG LuArgAsn乙eu Ar cj.T h r ?A g n Le u Leu A 丄 a Ph e Va JL Arς A i aV，a i Ly s H i s LeuG1 uAs nA i a Se rG1 y 75 i leG luAiaIleLeuPvrgAsnLeaGlaProCysLeuProSerAiaThrAlaAlaProSer -231 -

O:\92\92747.DOC 200413407 ΛrgH i 5 P r ο 11 e I ie 11 eLys A1 aG 1 yAspTrpG i nG 1 u ?heArgG 1 uLys LeuThr Phe Tyr LeuVaiThrLeuGluGlnA i aG1nGIuG1nGInTyrVa1G1uG1yG1yG1yG1yS e r PiroGlyGLuProSerGlyPiroIleSerThrl leAsnPrroSeirProPrOSeirLysGJLiiSei: HisLys'SerProAsrLMetAlaArgPheValGlnThrAsal LeSerArgLeuLeuGlnGlu 5 ThrSerG LuGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCys L e uG 1 u L e uG 1 nC y s G i η P r o As p S e r S e r T h r L e uG i yG 1 y G1 y S e r G1 y G1 y G1 y S e r G1 y G i y G1 y S e r G1 y G1 y G1 y T h r GI ρ〇Λ s p C y s 5 e r ? h e G1 η H i s S e r P r ο 11 e S e r 3 e r AspPheAiaValLysIleArgGluLeuSerAspTyrLeuLeuGln-^spTyrProValThr ValAIaSerAsnLeuGinAspGiuGiuLeuCysGr/GlyLeuTrpArgLeiiValLeuAla 10 GlrLArgTrpMecGluArgLeuLysThrValAiaGlySerLysMetGlnGiyLeuLeuGlu ArgVaiAsaThrGluIieHis PheValThrLysCysAiaPheGlnProProProSerCys Leu SEQ 工D NQ.-629 1 5 hflt3-9 3991inkl0.pep

Leu LeuAs p ? r o As nAs nLeuAs n S e r G i u·二.s pMe t As p 工 13L euMe tG 1 uAr g As nLe u ArgThrProAsnLauLeuAlaPheValArgAlaVaiLysHisLeuGiuAsrLAlaSerGly 20 IleGluAlalleLeuArgAsaLeuGiaProCysLeuProSerAiaThrAlaAlaProSer ArgH isProliellel1eLysAlaGIyAs pTrpG i nG1u ? heArgG1uLy3 LeuThr ?he Ty rL eu Va IT hr LeuG 1 uG 1 aA I aG 1 nG i uG I nG 1 nTy r Va 1G ί uG IyG1 yG I y S e r S e r PrGGlyGluProSerGlyProIleSerThrlleAsnProSerProProSerLz/sGluSer His Ly s S e r P r o As nMe t: A i aTh r As η 11 e 3 e r Ar gLe a LeuG 1 nG 1 uT h r 3 er G i uG 1 n 25 LeuVaiAlaLeuLysProTrpIleThrAjrgGlnAsnPheSer'ArgCysLeuGiuLeuGln C y s G1 χΊ P r o A s p S e r S e r T h r L e u G1 y G1 y GI y S e r G1 y G1 y G1 y S e r GI y GI y T h r G1 n AspCysSerPheGlnHisSerProIleSerSerAspPheAiaValLysIleArgGIuLeu Ser AspTy r L euLeuG I nAs pTy r ?r oVa lThrVa 1AI aS er As nLeuG 1 pG luG 1 u

LeuCysGlyGiyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThr 30 Va I Al aG IyS er LysMe tGInGlyLeuLeuG1uArgVa1As nThrG iu11eH i s PheVa1

ThrLysCysAlapfieGlni)r.3Pr〇Pr'〇SerCysLeui\rgPheVaiGln SZQ ID MO：530 35 hf!t:3-9 3 99 1 ink.15 . pep

AlaAsnCys S er11eMe C11eAs pG i u 工1e11eH i sH i s LeuLysArg ProAsnPro

LeuLeuAspProAsnAsnLeuAsnSerGluAspMetAspIieLeuMecGluArgAsnLeu Ar gThr ?r oAs nLeuLsuAi a PheVa I Arg*\l aVal Ly s H i s LeuG luAs r^Ai aSerG i y 40 I ieGluAlal leLeuArgAsnlieuGlnProCysLeuPiroSeirAlaThr'AlaAlaProSer

ArgKis Prclieliel1eLysAlaGlyAspTrpGInGluPheArgGluLys LeuThr ?he Ty rL e uVa i T h r L e uG 1 uG i「“仏iG 1 nG 二 G1 hG 1 nTy rT‘/a 1G1 uG i yG 1 θ 1 yG L y S e r ProGV/GiuProSeirGiyProIleSerThrlieAsnPiroSeirProPrcSerLysG 丄 uSer His 乙 ysSerProAs nM e 匕 A1 a T h r A s η 11. e S e r A r g L e U· L e u G1 n GI u T h r S e r G l· u G i n 45 LeuValAIaLeuLys?roTrpIieThrArgGlnAsn?hsSerArgCysLeuGIuLeuGIn CysGinProAspSerSerThrLeuGlyGiyGlySerGlyGlyGlySerGlyGlyGlySer G1 yG i yG 1 v^T h r G1 n.As pCy s S e r P heG 1 nH i s S e r ? r ο 11 e S e r S e r As p ? he A1 a Va 1 LysniAr&GluLeuSerAs'pTyzrLeuLeuGinAspTyrPrQValThr'/aiAlaSerAsr: LeuGip^spGluGluLeuCy3GlyGl：ALeuTrpArgLeuValLeuAlaGlr-\rgTrpMet 50 GIuArgLeuLysThrValAIaGIySerLysMecGlnGiyLeuLeuGiuArgVaiAsnThr GluIIeHisPheVaiThrLysCysAlaPheGlnProProProSerCysLeuArgPheVal

Gin SEQ ID MO :631 55 hfIt3-2329Iink6.pep

Al aAsnCys S er 工]_ eMe t 工 i eAs pG lu 工 1 e 工 1 eH i s H i s LeuLys Ar g Pr o o As nP tro L e u L e u A s p ? r ο Λ 5 π A 3 n L e u A s n S e r G1 u A s p M e c A 3 p 11 a L e u M e t G1 u Λ r g A s n L e u

ArgThr ?r o As nLeuLeuAi a PheVa 1 Ar g A i aVa I Ly s H i s LeuG I uAs r；Ai a S erGi y 60 I leGluAial leLeuArgAsnLeuGinPiroCysLeuPr'oSerAlaThr'ALaA 丄 aProSer

ArgHisProIieneneLysAlaGii/AspTr'pGlnGluPheArgGiuLysLeuprPhe Ty i: L e uVa 1T h r L e uG 1· uG 1 nA i aG 1 nG 1 uG 1 nG 1 nTy it Va l· G1 uG i yQ 1 L yG y S e r ?roGlyGlu?roSerGiy?roIleSerThrllsAsnProSerProProSerLysGiuSer H i s L y s S e r P r c A s η M e c A1 a A s p T y r P r ο V a IT h r' / a IA1 a S e r A s n L e u G1 r^A s p G i u 65 (31 u L e u C y s G1 y GI y L e u T r p A i: g L e u V a IL e u AI a GI n A r g T r p M e c G1 u A r g L 5 u L y s 丄，/LeuLeuGluArgValAsnThrGluIleHisP^ie V a 1T h r: L y 3 C y s A i a ? h e G i n ? r* o ? r ο P r 〇 S <e r Cs L e u A r g P h V a 1G i r‘ T h r Λ s n 工丄 e SerArgLeuL^uGlnGluThrSerGIuGlnLeuVaiAliiLeuLyGProTrp：leThrArg GLrLAsnPheSeirArgCysLeuGi'jLeuGLnC'/sGLriProAspSeirSerThrLeuGiyGL·/ 70 GiySerGiyGiyThrGlrLAspCysSerPheGlnHisSerProIi^SarS-arAspPheAia VaiLys I leAr-:rG luLeuSerAspTyrLeuLeuGIn SEQ 二D MC ： 6 3 2 h: U3-：^291Lnk7 .cep 75 232-

O:\92\92747.DOC 200413407 VA / ^ vv- \ 匕厶<J /

AlaAsnCysSer I ieMe 11 LeAspG 1 uI l·eI ieHisHisLe'」L//s ArgP!：〇 pr〇AsnPro LeuLeuAs p Pro As r^\s nLeuAsnSerGIuAs pMe t:Asp I leLeuMe tG luArgAs nLeu ArgThrProAsnLeuLeuAlaPheValArgAlaValLvsHisLeuGluAsrL^iaSerGiy IlsGluAlal LeLeuAirgAsnLeuGinProCysLeuProSerAiaThirAiaAiaProSer· 5 ArgHisProUelleneLysAlaGlyAspTirpGinGiuPheArgGiuLysLeuThirPhe TyrLeuValThrLeuGluGlnAlaGInGluGlnGlnTyrValGLuGLyGIyGiyGlySer ProGiyGlu?rc3erGiy?roIleSerThrIieAsnProSerProProSerLysGiuSer HisLysSer ProAsnMetAlaAspTYrProV'alThrVaL'laSerAsrLLeuGlnAspGlu GluLeuCysG lyGlyLeuTrpArgLeuVcaiLeuAlaGlnArgTrpMe tG jluArgLeuLys 10 T hrV alA1aG1y5 e rLysMe CG1aGlyLeuLeuG i uArgVaIAs nThrGlulleH i s ?he

ValThrLysCy3AiaPheGlnPro ProProSerCysLeuArgPheValGlnThrAsnlle S e r A r g L euLeuG 1 p.G 1 uThr Se r G i uG I nLeu Va IAI aL eu Ly s ? r oTr p 11 eTh r Ar g GI π.λ3 η P he S e rAr gCy 5 L e uG 1 uL· e uG I nC y 3 G i η P r c A s p S e r S erT h r L e uG i yG I y G1y S e rG i yG1yGIyT h rGI r^s pC ys SerPheGlnHisSerProIieSerSerAspPhe 15 A1aVaILysIieArgGiuLeuSerAspTyrLeuLeuGIn SEQ ID MO :533 h f113 - 2 3 2 9 1inkl3. pep 20 AlaAsnCysSerIleMetIIeAscGluIieIIeHisHisLeuLysArg?ro?roAsn?ro LeuLeuAspProAsr^snLeuAsnSerGluAspMetAspIleLeuMetGiuArgAsnLeu Ar gT h r ? r o As nL eu L e uA 1 a ? h e Va i Ar g A i a Va IL y 〇 H i s L e uG 1 uAs r.A 1 a S e r G i y 工leGluA丄alleLeLiArgAsnLeuGlnPrcCysLeuPrcSerAlaThrAlaAiaProSer _ Ar gH i s ?r ο 11 e I i e 11 eLys Ai aG IvAspTrpG 1 r.G luPheAr gG I uLy s LeuThr Phe 25 TyrLeuValThrLeuGluGi.^AlaGlnGiuGlnGlnTyrValGluGlyGlyGlyGlySer ProGlyGluProSerGiyProIleSerThrIieAsnProSerPrcProSerLysGiuSer Piis L'/s Ser ?roAsr‘He 匚AlaAspTyr Pro Va iThrVa iAlaSer AsnLeuG LnAspG l_u GluLeuCysGIyGlyLeuTrpArgLeuValLeuAiaGinArgTrpMecGluArgLeuLys ^ T hr V 三 i A1 a_G 1 y S e r Ly s Me t G1 nG 1 y L e ii L e uG 1 u Ax' g V a 1 As nT? h rG 1 u 11 e H i s P h e 30 '/alThrLysCys▲仏 PheGln?ro?rb?roSerCysLeiiArg?heValG；LrTThrAsnI；Le S e r A r g L e' j. L e u G1 p. G1 u T h r S e r G1 u G1 p. L e u V a I λ I a L e u L y s ? r ο T r p 11 e T h r A r g GlnAsnPheSerArgCysLeuGluLeuGinCysGlnPrcAspSerSerThrLeuGiyGiy Gly S e rG i yGIyG1y S e rG1yG1yG i yS e rGi yThrG1nAs pCys S e r ? heG i nH i s S e r P r ο 11 e S e r S e r As o Phe AI a Va I Ly s X1 e Ar gG I uLeu S e r As oT'/ r L e uL e uG I n 35 SEQ ID MO：634 ' hflt3-2B29i ir.k21. pep 40 AlaAsnCysSer 二 ieMetl leAspGiu工 lelleHisHisLeuLiysAirgPr'GProAsnPro LeuL·euAs p ?r c As nAs nLeuAs nS erGIaAs pMe tAs p11eLeuMe tGIuAr gAs nLeu A r g T h r P r o A s n L e u L e u ΛI a ? h e V a i Λ r g Λ i a V a IL y s H i s L e u G1 u Λ 3 ru~. 1 a 3 e r G i y IleGluAlalieLeiiArgAsnLeuGinProCys LeuProSerAlaThrAlaAlaProSer ArgHis Pro IIslleileLysAlaGIyAspTrpGInGluPheArgGluLysLeuThrPhs 45 fr：/rIJeu'/a；LThrIJeuGiuGinAlaGl?\GiuG：Li::Gl:rTyr'/5LlGluGiyG：LyGlyGlySer· PrcGlyGluProSerGlyProIleSerThr I LeAsnProSer PrroProSeirLysGiuSei: HisLysSerProAsriMetAI a Va IAI aG i y S e r Ly s M e c G1 nG 1 y L e u L e uG I u Ar g Va 1 A s n T h r G1 u 工 i e H i s P h e V a 1T h r L y s C y s A1 a ? h e G1 η P r c· P r 〇 P r 〇 S e r C v s L e u A r g ? h e V a IGI π T h r Λ 5 η 11 e S e r A r g L· e u L e u G1 r. G1 u T h r S e r G1 u G i n L e u V a 1AI a L e u 50 Ly s Pr οT rp 11 eThr ArgG1 r.A3n?h^Ser Ar gCy 3 LeuG1 uLeuG inCy sG1 ηPr o Asp

SerSerThr^euGiyGlyGlySerGiyGlyGiySerGlyGlyGiySerGlyGlyGlySer G L y G1 y G1'/ S e:: G ΙγΊ1 h r G i rJ\ s p Cs S e r ? h e G1 r· H i s S e r P r c 二 1 e S <2 r S e r λ s p ? h e A1aVaIL y sIi eAr gGIu L eu S e rAs pTy r L e u L euGIaAs pTy r ? r οVaITh r Va1A1a 5 e r A s nL e uG 1 rJ^.s pG I uG 1 u L e uC y s G1 y GI y L euT rp Ar g L e uVa 1Le u A i aG1 η-λr g 55 TrpilecGluArgLeuLysThr SEQ^ ID NO ： 63 5 hfic3 -3 435imk6 .pep 60 AlaAsnCysSerlieMetIleAspGiuIieIleHisHisLeuLysArgProProAsnPro LeuLeuAsp Pro As p,As nLeu AsnSerG luAspMetiAsp 11 eLeuMecG luArgAs nLeu A r g T h r P r o A s n L e u L e u Λ1 a ? h e V a i A r g A i a v* a 1L y 3 H i s L 0 u G1 u Λ 5 I a S e r GI y 11 e G b i A1 a 11 e L & u A r .g A s n L e u G1 η P r c C y s L e u ? r o S e rA i a T ’n r A'i a A1 a P r o S e r ArgHisProIlellelleL-'/sAlaGiyAspTrpGinGluPheArgGluLysLeuThrPhe 65 TyrLeuVaiTarLeuGiuGinAlaGl^GiuGlnClnTyrValGiuGiyGiyGiyGiySer ?roGlyG i uProSerG ly ?ro I leSerThr I leAsn?roSer Pro PrroSerLysGiuSei: H i s L y s 3 e r ? r c A 3 r. M e c A1 a A1 a S e r A s n L e u G1 p--. s p GI u GI u L e u C y s G1 y GI y L 0 u T r p Λ r g L e u' / a L L e u A1 a GI a A r g T r p M e c G1 u Λ r g L e u L y s T h r V a 1A L a GI y 3 e r L y s M e c G1 r.G 1 y L e u L e uG 1 uAr gVa I As nT h r G1 u I i e H i 3 P h e V a 1Th r Ly s C y s A1 a P h e 70 Gin?::c?:：3Pr3Sei:CysL^LiArgPhe'/a’；*G：LrVThi:A；3nI]_eSe]：ArgLeLiLeuGinGiu

ThrSerGiuGinLeuVaiALaLeuLysProTrpIieThrArgGIriAsnPheSerArgCys L e uG i u L e uG JL nC y s G i η P:: ο As ρ S e r :S e r T h r L e uG 1 '/G L y G L y S e r G .L y G i y ·Γ h rG 丄 n

AspCvr, Se r PheG laKisSer Pro I leSer SerAspPheAIaVa i Lys I ieArgG luLeu SerAsryr/rLeuLeuGinAisoTvr ProVa丄ThrV.cii SEQ ID ：·,Ό ： 5 3 b 75 ' 233 -

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AlaAsaCysSer I leMet I leAspGlu! lelieHisHisLeuLysArgProProAsnPro 5 LeuLeuAspProAsnAsnLeuAsnSerGiuAspMetAspIleLeuMetGluArgAsnLeu

ArgThrProAsnLeuLeuAlaPheValArgAlaValLysHisLeuGluAsnAlaSerGly IleGluAlalleLeuArgAsnLeuGLnProCysLeuProSerAlaThrAlaAlaProSer ArgHis Pro IleilelleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe T y r L e u V a i T h r L e uG 1 uG Ϊ nA 1 aG 1 nG 1 uG 1 nG 1 nTy r V a i G1 uG 1 yG 1 yG I y G1 y S e r 10 ?rGGiyGlu?roSerGlyPrcIleSerThr工leAsnPr〇SerPr〇ProSerLysGiuSer H i s L y s S er P r o As niMe c A1 aA 1 a 3 e r As nL e uG 1 nAs pG 1 uG 1 uL e uC y s G1 yG 1 y Le u TrpArgLeuValLeuAlaGln^rgTrpMetGluArgLeuLysThrValAlaGl：/SerLys Mei:GlnGiyLeuLeuGiuArgVaiAsnTh]：GluI]_eHisPiie\/alThrLysCysAla?iie GlnProProProSerCysLeuAr*gPhe\/alGlnTh:rAsnIleSe;rA:rgLeuLeuGlnGlu I 5 ThrSerGiuGinLeuValAlaLeuLysProTrpILeThrArgGlnAsnPheSerArgCys LeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlyThr GlnAspCysSerpfieGlnHisSerProIleSerSerAspPheAlaValLysIleArgGlu L· e u S e rAs pTvrL e u L euG i aAs pTyr ? rοv aIT hrVa1 SEQ ID NO：6 3 7 20 hfIu3-34351inkl3.pep '

AlaAsnCysSerIleMetlleAspGluIlelleHisHisLeuLysArgPrcProAsnPro LeuLeuAs p P r g As nAs nL eu As n S e r GI uAs pMe C As p 工]_ eLeuHe tG 1 uAr g As nLeu 25 ArgThr P r 〇As nLeuLeuAi a?heVa 1 Ar gAi aVaiLy s H i s LeuG 1 uAsflMaSerG1 y

IleGluAlalleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAIaAlaProSer ArgHis Pro IleileileLysAlaGIyAspTrpGlnGiuPheArgGluLysLeuThrPhe TyrLeuVa iThr LeuGIuGInAlaG1nG1uG1nG i nTyrVa1G1uGIyGIyGIyGIy S e r ， ProGlyGluPrcSerGlyProIleSerThrlleAsnPrGSeirProProSerL’/sGluSei: 30 H i s Ly s S e r P r oAs nti e t A i aA 1 a S er As nL e uG i nAs pG 1 uG 1 u L euCy s G1 yG i y L eu

TrpArgLeuValLeuAlaGIn.\rgTrpHetGIuArgLeuLysThrValAlaGlySerLys Me t G1 nG i y L e u L e uG 1 u A r g V a ί A s n.T h r G1 Li 工 1 e H i s ? h e V a 1 ·Τ h r Ly s C y s A1 a ? h e GlnProProProSerCysLeuArgPheValGlnThrAsnlieSerArgLeuLeuGinGlu ” ThrSerGiuGinLeuVaiAiaLeuLysPrcTrpIleThrArgGlnAsnPheSerArgCys 35 LeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGIySerGlyGlyGlySer

GlyGlyGlySeroiyThrGlnAspCysSerPheGlnHisSerProIieSerSerAspPhe A1aVa i L ys11eArgG1uL eu S e rAs oTvr Leu L euG1nAs oTvr P roVaIT hrVa i SEQ ID MO :63 3 … 40 hrlt:3-3435 1 iak.2 1. pep A1 己As nCy s S er 11 eWe 11LeAs pG L11· e 11*i s H i s LeuLys Ar g P]： o ?r oAs n ?r o _ LeuLeuAsp?roAsnAsnLeuAsnSerGiuAspMetAspIieLeuHet:GluArgAsnLeu 45 ArgThr ProAsnLeuLeuAIaPheValArgAlaValLysHisLeuGluAsnAlaSerGly IleGluAlal leLeuArgAsnLeuGin?rGCysLeu?r〇SerAlaThrJ\laA；la?roSer Ar g H i s ? r ο 工e 11 e 11 e L y s A1 a_G 1 y As ρ，Γ r pG 1 r‘G 1 u ? h e Ar gG 1 u Ly s L e u.T h r ? h e TyrLeuValThrLeuGiuGinAiaGlnGluGinGlnTyrValGluGlyGlyGlyGiySer 一 ProGlyGluProSerGIyProIleSerThrHeAsn?roSer?ro?rcSerLysGiuSer 50 卜:i s L y s S e r P〇 A s nH e c A i a A1 a S e r A s n L e u G i n A s p G1，J G1 u L e u C y s G i y G1 v. L e u

TrpArgLeuValLeuAlaGlnArgTrpMecGiuArgLeuLysThrValAlaGiySerLy〇 Me tG InG iyLeuLeuGluArgVaIAsnThrG iul1eH i s PheVaiThrLysCysAlaPhe GInPro?roProSerCysLeuArg?heValGlp.ThrAsnIleSerArgLeuLeuGIr.Glu -· ThrSerG 1 uG InLeuValAlaLeLilz/s ProTrpIieThrArrgGlnAsnPheSerAirgCys 55 L e u G1 u L e uG i nC y 3 GI n ? r 〇 A. s p S e r S e r T h r L e uG 1 y G1 y G1 y S e r G1 y G1 y G1 y S e r G1 yG i y GI y S e r GI y GI y G1 y S e r G1 yG 1 y GI y S e r G1 y T h r G1 aAs pC y s S e r ? h eG 1 a H i s S e r ? r c I i e S e r S er As p P h e A1 aVal Ly 311 eAr gG I uL eu S e r As pTy r Leu L eu GlnAspTvrProValThrVal SEQ ID MO : 63 9 60 hflt3-5253iink5.pep AlaAsnC’/sSer I LeMet I ieAspGluI l_el _ LeuLeuAsc?roAsn.AsnLeuAsnSerGluAspMecA3pIleLeuMetGIuArgAsnLeu 65 ArgThrProAsnLeuLeuAlaPheVaiArgAlaValLysHisLeuGluAsRAiaSerGly I LeG LuALal L-aLeuArgAsnLeuGip.ProCysLueuPiroSerAlaThrAlaAlaProSer: ArgHis Pro 1 le I IleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThr Phe Ty r L eu Va i Γ h r L e uG 1 uG 1 nA1 aG i r.G 1 uG I aG 1 p.Ty r Va 1GI uG 1 yG i yGI y GI y S e r PrcGlyG 1u?roSerGlyPro IieSerThrIleAsaProSerPro ProSerLysGluSer

70 HisLy3 J亡：：？:：ο·ΑsηMet:Aia'/aiAiaG!，/SerLysMetG Lr\G LyLeuLeuG1 uArgVaL s αT h] i u Ie h i :3 Phe Va L'Th r L/·/s Cy s A l a ?heG i η P r:c ? r ο P r· ο ε e rC7 s LeuAr g ?he'/.d l··.：； 1 :，.T hr As η I ieSe:: Arg LeuLeuG i nG :::3 e i:G LuG InLeuVa 1Λ la Leu Lys?r:〇Trp I le.ThrArgG inAsnPheSerA::gCysLeuGiuSLeuGlnCy3Gln?roAsp 3 e re rT h r uG I yG L yG L y S e rG1 yG 1 yThrGI r.As pCy 3 S e r P heG i aH i s S e r P ro 75 IleSerrSerAspPheAIaVaiLyslieArgGluLeuSerAspTyrLeuLeuGinAopTyr O:\92\92747.DOC -234- 200413407

ProValThrValAiaSerAsnLeuGInAspGiuGluLeuCysGlyGlyLeuTrpArgLeu ValLeuAlaGlnArgTrpMetGluArgLeuLysThr SEQ ID NO:d40 5 hf113-62 63link7. pep

AlaAsnCysSer I leMetilleAspGluI Le 工 leHisHisLeuLysArgPro?z:oAsn?i:o LeLiLeuAspProAsnAsnLeuAsnSerGluAspMetiAspIleLeuMetGluArgAsnLeu ArgThrProAsnLeuLeuAlaPheVaiArgAlaValLysHisLeuGluAsnAlaSerGly I 〇 IleGluAlalleLeuArgAsnLeuGlnPrcC'/sLeLiProSerAlaThrAlaAlaProSer ArgHis ProIlellelieLysAlaGLyAspTrpGlnGluPheArgGluLysLeuThrPhe TyrLeuVaiThrLeuGluGlnAlaGlnGiuGlnGlnTyrValGluGlyGlyGlyGiySer ProGlyGluProSerGlyProIleSerThrILeAsnProSerProPrcSerLysGluSer HisLysSerProAsni^etiAlaValAlaGlySerLysMecGlnGIyLeuLeuGluArgVal l 5 AsnThrGluIleHis PheValThrLysCysAlaPheGlnProProProSerCysLeuArg

PheValGlnThrAsr.IleSerArgLeuLeuGlnGluThrSerGluGlnLeuVaiAlaLeu LysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGInProAsp S e r S e rT hr L euG1yGIyG1yS e rGIyGIyG1yT h rG1nAs pCys S er P h eG1nH i s S e r ProIIeSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAsp 20 TyrProValThrValAiaSerAsnLeuGlnAspGiuGiuLeuCysGlyGlyLeuTrpArg LeuValLeuAlaGlnArgTrpMecGIuArgLeuLysThr SEQ ID MO：641

hflt3 -6263linkl3. pec 25 ·

AlaAsnCysSerIleMetIleAspGluIlelleHisHisLeuLysArgProProAsnPro LeuLeuAsOProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetCluArgAsnLeu ArgThr P roAsnLeuLeuAlaPheValArgA1aVaiLys Hi s LeuGluAsnAlaSerGly ^ IleGluAlalieLeuArgAsnLeuGlnPrcCysLeuProSerAlaThrAlaAlaProSer 30 ArgHis Prol LeII_«sIleLysAlaGl>yAsp.TrpGLr‘Glu?heArgGluL//sLeuTh;rPhe

Ty r L e u Va 1T h r L e uG 1 uG i nA i aG 1 nG I uG 1 nG i nTy r Va IGI uG i y G1 y G1 yG 1 y S er PrcGlyGluProSerGlyProIleSerThrlleAsnProSerPrQProSerLysGluSer HisLysSerProAsp^letAlaValAlaGlySerLysMecGinGlyLeuLeuGiuArgVal ^ AsnThrG；lu：CleHisPheVTalThrIjysCysAlapiieGlnPro?ro?roSerCysL«auArg 35 PheValGlnThrAsnlleSerArgLeuLeuGlnGluThrSerGiuGlnLeuValAlaLeu

LysProTrpIleThrArgGlnAsnPheSsrArgCysLeuGluLeuGInCysGInProAsp SerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGIyThrGlnAsp CysSerPheGlnHisSerPrcIleSerSerAspPheAlaVaiLysIleArgGiuLeuSer AspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeu 40 CysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMecGluArgLeuLysThr SEQ ID NO：642 ^ hflt3-62631ink21.pep 45

AlaAsnCysSer I leMetlleAspGluI l*el leHisHisLeuLysArgPrcPrcJXsnPro LeuLeuAspProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGiuArgAsnLeu A r gT h r ? r o As nL eu L euAIa P h eVa1ArgAIaVa1Lys H i 5 L euG1uAs nAIa S e rGIv _ IleGluAialleLeuArgAsnLeuGinProCysLeuProSerAiaThrAlaAlaProSer

50 Ar gH i s ? r 〇 11 e H e I i e Ly s A1 aG ! y As p.T r pG JL nG 1 u P he Ar gG 1 u Ly s L eii.T hr P he

TyrLeuValThrLeuGluGlnAlaGlnGluGinGinTyrValGiuGlyGlyGLyGlySer ProGlyGiu?roSerGlyProIleSerThrIleAsnProSerPro?roSerLysGluSer H i s L y s S e r ? r o A s nM e t A1 a V a 1A i a G1 y S e r L y s M e t: G i n G i y L e u L e u GI u A r g V a 1 “ As nTiirG 1 u 工 i eH i s PheVa lThr Ly s Cy s A la pfieG lnPr〇Pro?roSe r Cy s Le’a Ar g 55 ? h e V a IG1 η T h r A s η 11 e 5 e r A r g L e u L e u GI n G1 u T h r S e r G1 u GI n L e u V a IAI a L e u

LysProTrpIleThrArgGlnAsnPheSerArgCysLeuGiuLeuGlnCysGinProAsp SerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGLyGlyGiySer GlyGIyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIieSerSerAspPhe A1 a V a i L y s I i e A r g G i u L e u S e r A s ρ T y r L e u L e u GI n A s p T y r P r ο V a 1T h r V a 1A i a 60 S e r As nLeuG i nAs pG 1 uG I uLeuC y sG1 yG1'/LeuT rp Ar g LeuVa ILeuAI aG 1 nAr g

TrpMecGLuArgLeuLvsThr SEQ*ID MO :643 hfLc3-9495Iink6.oeo 65 '

AlaAsnCysSer·I LeMe11 丄eAspGiullel ieHisH‘isLeuL//sArgPro?roAsnP::〇 LeuLeuAsp ProAsnAsuLeuAsnSeirG LuAspMetAsp I leLeuMe tGluArgAsnLeu ArgThr ProAsn LeuLeu Ala PheValArgAi aVa·

IleGluAialieLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer Ar gH i 3 P r ο 11 e 11 e 11 e L v 3 A1 aO I yAs pT rp $ 1 nC ί u P he Λr gG 1 u Ly 3 LeuT hr P he TyrLeuValThrLeuGiuGiaAlaGinGluGinGlnTyrValGluGiyGLyGiyGlySer PiroGiyCLuProSerGl’/ProI ieSerThrl ieAsnProSerProProSerLysGluSei: HIsLysSerProAsaMetAiaArgPheVaiGinThrAsnlLeSerArgL-euLeuGlnGiu ^ ThrSerG 1 uG 1 nLeuVa iΛ laLeuLy3 ProTrρ 11 eThr Arg〇 1 nAsn?heSerArgCys 75 LeuG 1 u LeuG i nCy sG1 η ? r o As p S e r S e rTh r LeuG 1 yG I yG 1 y 3 e rG1 yG 1 yT hrG1 n O:\92\92747.DOC -235 - 200413407 isSezrPro 工 LeSeirSeirAspPlieAiaVcilLys I ieArgGluLeu SerAspTvrLeuLeuGlaAspTyrProVaiThrValAlaSerAsnLeuGinAspGluGlu LeuCysGlyGlyLeuTrpArgLeuVaiLeuAlaGlnArgTrpMecGluArgLeuLysThr ValAlaGl'/SerLysMetGiaGlyLeuLeuGluArgValAsnThrGiuIieHis PheVal ThrLysCysAiaPheGln?ro?roProSerCysLeu 3EQ ID MO :644 hfIt3-94951ink7.pep 10 AiaAsnCysSerl leMeclleAspGluIIelleHisHisLeuLysArgProProAoriPro LeuLeuAspProAsr^snLeuAsnSerGluAspMetAspIleLeuMetGiuArgAsnLeu ArgThrProAsnLeuLeuAlaPheValArgAlaVaiL'/sHisLeuGluAsnAlaSerGly 工leGluAla工 ieLeuArgAsnLeuGlnProCysLeuProSerAlaThrAiaAlaProSer Argh’isPro I le IlelleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPhe l 5 Tyr LeuVa1ThrLeuG1uG1nA1aG1nG1uG1nGinTyrVa1G1uGIyG1yGlyGlySer

ProGlyGiu?roSerGlyProIleSerThrIleAsnProSer?r〇ProSerLysGluSer HisLysSer?roAsr.Met:AlaArgPhsVaIGinThrA5nIleSerArgLeuLeuGlnGlu ThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGinAsnPheSerArgCys LeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGiyGlyGlyThr 20 GlnAspCysSer?fieGlnHisSerPr〇IleS«srSerAspPheAlaValLysIleArgGiu LeuSerAspTyrLeuLeuGlaAspTyrProValThrValAiaSerAsaLeuGlnAspGlu GluLeuCysGlyGlyLeuTrpArgLeuVaiLeuAiaGlriArgTrpMeCGIuArgLeuLys Th.rValAlaGlySerLysMecGiaGlyLeuLeuGiaArgVaiAsnThrGluIleHis?he VaiThrLvsCvsAlaPheGinProProProSerCysLeu SEQ ID NO：645 25 hflt3-9495iinkl3.pep A1 aAs nCy s S e r 12* eM e 111 e As pG 1 u 工 1 e 11 eH i s H i s L eu Ly s Ar g ? r c ? r o A s η P r ◦ 30 heuL euAs p P r o As nAs nLeuAs nS e rG i uAs pMe tAsp11eL euMe tG1uAr gAs nL eu ArgThrProAsnLeuLeuAiaPheVaiArgAlaValLysHisLeuGluAsnAlaSerGly IleGluAlalleLeuArgAsnLeuGInPrcCysLeuProSerAlaThrAiaAlaProSer ArgH i s ?r ο 11 e 11 e 11 eLys Ai <aG 1 yAspTrpG 1 nG 1 u PheArgG 1 uLys LeuThr ?he TyrLeuValThrLeuGluGinAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGlySer 35 ProGlyGluProSerGlyProIieSerl'hrlleAsnPrcjSerProProSerLysGluSer HisLysSerPrQAsaMetAlaArgPheVaiGlnThrAsrilieSerAirgLeuLeuGlnGlu ThrSerGiuGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCys LeuGluLeuGInCysGlnProAspSerSerThrLeuGlyGlyGlySerGiyGIyGlySer GlyGlyGlySerGlyThrGln.^spCysSerPheGlnHisSerProIleSerSerAsp?he 40 AlaValLysIieArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAla SerAsriLeuGlnAspGluGiuLeuCysGiyGlyLeuTrpArgLeuValLeuAlaGlnArg T r pMe tG i uAr g Le u Ly s·ΤhrV’a 1A1 aG i y S e i: Ly s Me tG 1 nG 1 y LeuLeuG 1 uAr gVa 1 AsnThrGiulieHisPheVaiThrLysCysAlaPheGlaProProProSerCysLeu SEQ ID MO :546 45 hf It:3-9495Iink2i . pep

AlaAsnCysSerlleMecIieAspGIuIlelleHisHisLauLysArgProProAsnPro 50 LeuLeuAsp Pr o AsnAs nLeuAs nSe rX} 1 uAscMe c*:\sp I i eLeuHe tG iuAr gAsnLeu

ArgThrProAsaLeuLeuAlaPheValArgAlaVaiLysHisLeuGluAsriAlaSerGly IleGiuAlalleLeuArgAsnLeuGlaPrcCysLeuProSerAlaThrAlaAlaProSer ArgHisPr'criellelieLysAlaGiyAspTr'pGlnGliiP’nsAr'gGiuLysLeLTrhrPhe TyrLeuVaiThrLeuGluGlaAiaGInGluGir.GlnTyrValGIuGiyGlyGlyGlySer 55 ProGlyGluProSerGivProIleSerThrlleAsnProSerProProSerLysGiuSer H i s L y s S e r ? r o A s η M e r_ A i a A r g P h e V a i G l· n 了 h r A s n 工 i e S e r A r g L e u L e G1 nG 1 υ ThrsirGluG：LnLeuVa：LAlaLeu：//sPr〇TrpI：le-ThrArgG：LrLAsn?heSerArgCys L e u G i u L e u G1 n C'/ 3 G1 n ? r o A s p S e r S e r T h r L e u G1 y GI y G1 y S e r GI y G1 y GI y S e r GlyGiyGiySerGiyGiyGlySerGIyGLyGiySerGlyThrGlru^spCysSerPheGln 60 HisSerProIleSerSerAspPheAIaValLysIieArgGluLeuSerAspTyrLeuLeu GlnAspTyrProValThrValAiaSerAsnLeuGlnAspGluGluLeuCysGlyGiyLeu TrpArgLeuVaiLeuAlaGlnArgTrpMetGiuArgLeuLysThrValAlaGiySerLys MetGlnGlyLeuLeuGluArgValAsnThrGiuIleHis?heVaIThrLysCysAlaPhe GinProProProSerCvsLeu SEQ ID NO:647 65 h f 113 - 93 9 9 1 i:i!<6 . pep

AlaAsaCysSerrleMecIieAspGluIIelleHisHisLeuLysArgProProAsnPro 7〇 LeuLeuAspProAsrLAsp.LeuAsnSerGLuAspMetiAspI-eLeuMetGiuArgAsnLeu

Arg^^hrPrcAonLeuLeuAiaPheValArgAiavalLysHisLeuGiuAsnAlaSerGly lieGLuAianeLeuArgAsnLeuGLnProCysLeuPrcSeirAlaThirAlaAiaPrcSer· ArgKLsPrcIlellelleLysAlaGlyAspTrpGlnGluPheArgGLuLysLeuThrPhe TyrLeuvalThrLeuGluGlr^laGlnGIuGlaGlnTyrVaLGluGlyGlyGiySerSer 75 ProGiy〇i^?roSerGly?roIleSerThrIleAsnPrcSerProProSerLysGluSer

O:\92\92747.DOC -236- 200413407

HisLysSerProAsniletAiaThrAsnlleSerArgLeuLeuGinGluThrSerGluGln LeuValAlaLeuLys ProTrpIleThrArgGlnAsnPheSerArgCysLeuG LuLeuGln CysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGiyThrG iaAspCysSerPhe GlnHisSerProIleSeirSerAspPheAlaValLys I leArgGluLeuSerAspTyirLeu 5 LieuGioAspTyirProValThxr'/aiAiaSerAsnLeuGlnAspGluGluLeuCysGiyGiy LeuTrpArgLeuVaiLeuAlaGInArgTrpMecGluArgLeuLysThrVaiAlaGlySer LysMetGlnGlyLeuLeuGiuArgValAsaThrGiuIleHisPheValThrLysCysAia PheGInProPrcProSerCysLeuArgPheVa1Gin SEQ ID MO：643 10 hflt3~9B991ink7.pep

AiaAsnCysSerIleMetliaAspGluIlelieHisHisLeuLysArgProProAsnPro LeuLeuAspProAsnAsnLeuAsnSerGluAspMetAspIleLeuMetGluArgAsnLeu 15 ArgThrProAsnLeuLeuAlaPheValAirgAiaValLysHisLeuGluAsrLAlaSerGiy IleGluAlalleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer ArgHisProIIelielleLysAlaGlyAspTrpGinGluPheArgGluLysLeuThrPhe Ty r L e u Va 1T h rL e uG 1 uG 10.¾ I aG 1 nG 1 uG I nG 1 nTy r Va 1G1 uG 1 yG 1 yG 1 y S e r S e r ProGlyGluProSerGlyProIieSerThrlleAsnProSerProProSerLysGiuSer 20 HisLysSe2：P:rcAsnMet:AlaTh;rAsnIleSe:rAi:gLeuLeuGlnG；luThi:SerGluGin LeuValAlaLeuLysProTrplIeThrArgGlnAsnPheSerArgCysLeuGluLeuGln CysGlnProAspSerSerThrLeuG丄'/GlyGlySerGlyGlyGlyThrGlnAspCysSer PheGlnHisSerProIIeSerSerAspPheAlaValLysIleArgG1uL eu S e rAs pTyr LeuLeuGlrLAspTyrProVaiThrValAlaSerAsr.LeuGinAspGluGluLeuCysGiy 25 GlyLeuTrpArgLeuValLeuJUaGlnArgTrpMecGiuArgLeuL^/sThrValAiaGiy SerLysMetGlnGlyLeuLeuGluArg'/alAsnThrGluIleHisPkeVaiThrLysCys AlaPheGlnProProProSerCysLeuArgPheValGln SEQ ID NO：649 30 hfIt3-98991inkl3.pep

AlaAsnCysSerIleMe tilsAspGluIleileHisHisLeuLysArgPro ProAsnPro LeuLeuAspProAsaAsnLeuAsnSerGluAspMetAspIieLeuKetGiuArgAsnLeu i _ ArgThrProAsnLeuLeuAiaPheVaiArgAlaValLysHisLeuGluAsnAlaSerGly 35 IleGluAlalleLeuArgAsnLeuGlnPrGCysLeuProSerAlaThrAlaAlaProSer ArgHisProIIelielleLysAlaGIyAspTrpGInGluPheArgGluLysLeuThrPhe T y r L e uVa IT h r L euG 1 uG 1 nA 1 aGI r.G I uG 1 nG 1 nT y r Va 1G i uG I yG 1 yG I y S e r S e r ProGlyGiuProSerGlyProIleSerThrlleAsnPrcSerProPrbseirl^/sGluSer HisLysSerProAsni4etAlaThrAsnIieSerArgLeuLeuGlaGluThr5erGluGln 40 LeuValAlaLeuLysProTrpIIeThrArgGlr^snPheSerArgCysLeuGluLeuGln CysGlnProAspSerSerThrLeuGlyGiyGlySerGlyGlyGlySerGlyGlyGlySer GlyThrGinAspCysSerPheGinHisSerProlleSerSerAspPheAiaVaiLysIIe ArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrVaiAiaSerAsnLeuGin 一 AspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGir^rgTrpMetGluArg 45 LeuLysThrValAlaGlySerLysMetGLnGiyLeuLeuGiuArgVaiAsnThrGiuIle HisPheValThrLysCysAla?heGlnPro?ro?roSerCvsLeuArgPheValGln SEQ ID MO:650 ^ 50 hflt:3-9099Iink21 .pep 、

AlaAsnCysSerIieMetIleAspGluIleileHisHisLeuLysArgProProAsnPro _ _ ArgThrProAsnLeuLeuAlaPheValArgAlaValL'/sHisLeuGluAsnAlaSerGly 55 IleGluAialleLeuArgAsnLeuGinPrcCysLeuProSeirAlaThrAlaAlaProiSer· ArgHi s Pr ο 11 e 11 eI i eLysAiaG IvAspTrpG inC-1 uPheArgG 1 uLys LeuThr Phe Ty r L e u Va IT h r L e uG i uGI aA 1 aG1 nG i uG i nG 1 nT y r Va 1GI uG 1 yG i yGI yG1 y S e r ProGlyGiuProSerGlyPro IieSerThrIleAsnProSerProProSerLysGiuSer His Ly s S 0r P r o As nMe t A i aThr As η 11 e Ser Ar gLeuLeuG 1 nG I uTh r 3 e rG 1 uG I n. 60 Leu Va 1AI aL euLy s ? r οT r p 11 eT hr Ar gG i nAs η PheS e r Ar gCy s LeliGI u Le uGI n CysGlnPrcAspSerSerThrLeuGlyGlyGlySerGlyGiyGlySerGiyGlyGlySer G1yG1yG i ySe rG1yGIyG1yS erG1yThrG1nAspCysS er PheGInH i s S er Prolie SerSerAsp?heAlaVaILysILeArgGluLeuSerAspTyrLeuLeuGlYiAspTyrPro _ ValThrValAlaSerAsnLeuGinAspGiuGiuLeuCysGlyGlyLeuTrpArgLeuVal 65 LeuAiaG Lr^rgTrpMetGiuArgLeuLysThrValAlaGlySerLysMeCGlnGlyLeu Le uG I u Ar g Va I As r.T hr G1 u 11 e H i 3 P he Va IT hr Ly sCy s A1 a PheG i n ? r o ?r o Pr o SerCy〇LeuArgPheVa1G1n SEQ ID MO：651 ^ ^ 70 G LySerThrMetSerArgLe^PrcValLeuLcuLeuLeuGinLeuLeuvaiArgProAlaMeCSerThrAsnGln AispLeuPro’/ai Γ ieLysCysV.a iLeuI： IreAsnHisLysAsnAsrLAspSezrSerVaiGlyLysSerSozrSejrTyr ProMecVa iSerG LuSerProGluAspLeuGIyCysAlaLeuArgProGlnSerSerGlyThrValTyrGluAla • AiaAia'/a i.J LuVa LAspVa iSerAlaSer I ieT^rLeuG LnVa iLeuV.a iAspAlaProG LyAsnl leSerCys 75 LeuTrrp'/ai PheLysHisSerSerLeuAsnCysG LnPiroHis PheAspLeuGinAsnArgG丄yVa丄ValSerMet O:\92\92747.DOC -237 - 200413407

VallleLeuLysMetThrGiuThrGinAIaGlyGluTyrLeuLeuPheli^GlnSerGiuAlaThrAsnTyrThr: I leLeuPheThrVaLSei：]；

GlnAspAiaLeuValCysIieSerGluSerVal?r〇GluProIleValGluTrpVaiLeuCysAspSerGlnGly _ GluSer.CysLysGluGluSerProAlaValValLysLysGluGiuLysVaiLeiiHisGluLeuPheGlyMetAsp 5 UeArgCysCysAiaArgAsnGluLeuGlyAi:gGiuCysThrArgLeuPheThrIieAspLeuAsnGirvThr?ro GlnThrThrLeuProGlnLeuPheLeuLysValGlyGluProLeuTrpIleArgCysLysAlaValHisValAsn H i s G1 y P h eG 1，y'L e uT h r T r pG 丄 u Le uG i uA s n L y s A1 a L e uG 1 uG i uG 1· w''s nT，〉r P h eG 1 uMe 匕 S e r T h r Ty r SerThrAsr^rgThrMecileArglleLeuPheAlaPheValSerSerVaiAlaArgAsr^soThrGlyTyrTyr ThrCysSerSerSerLysHisProSerGinSerAlaLeuVaiThrlleValGLaLysGiyPhelleAsnAiaThr 10 AfriSerSeirGiLiAspTyrGJLuneAspGlrvTyrGluGluPheC'/sPheSer'/alAlgPh^LysAlaTyrPiroGin IieArgCysThrTrpThrPheSerArgLysSerPhePrcCysGIuGlnLysGiyLeuAspAsnGlyTyrSerlle SerLysPheCysAsnHisLysHisGlnProGlyGl'jTyrriePheHisAlaGIuAsnAspAspAlaGinPheThr LysMetPheThrLeuAsnlleArgArgLysProGlnValLeuAIaGluAlaSerAiaSerGinAlaSerCysPhe SerAspGlyTyrProLeuProSerTrpThrTrpLysLysCysSer.AspLysSerProAsnCysThrGluG丄 Lille 15 ThrGluGIyValTrpAsnArgLysAiaAsnArgLysValPheGIyGlnTrpValSerSerSerTlnrLeUx^snMet SerGluAla 工 leLysGJiyPheLeuValLysCysCysAiaTyrAsnSerljeiiGi'/rhrSerCysGluThrneLeu LeuAsnSerPrciGlyProPheProPhel ieGinAspAsnGluPhellelleLeiiGl^/LeuPheGlyLeuIjeuLeu LeuLeuThrCysLeuCysGlyT'hrAlaTrpLeuCysCysSerProAsnArgLysAsi^ProLeuTrpProSerVal ProAspProAlaHisSerSerLeuGiySerTrpVaiFroThrlleMetGluGiuAspAiaPheGlnLeuProGly 20 LeuGlyThrProProIleThrLysLeuThrValLeuGluGluAspGiuLysLysProValPrcTrpGIuSerHis AsnSerSerGluThrCysGlyLeuProThrLeuValGlr.TxhrTyrVaiLeuGinGIyAspProArgAlaValSer ThrGlnProGlnSerGLnSerGlyThrSerAspGlnValLeuTyrGiyGinLeuLeiiGiySerProThrSerPro GlyProGlyHisTyrLeuArgCysAspSerThrGlnProLeuLeuAlaGlyLeuThrProSerProLysSerTyr _ GluAsnLeuTrpPheGlnAlaSerPrcLeuGlyThrLeuValThrProAiaProSerGlr^GluAspAspCysVal 25 PheGiyPr'oLeuLeuAsnPheProLeuLeuGlnGlvlLeArgValHisGl'/MecGluAlaLeuGlySerPhe SEQ ID MO :652 pMCM3 032 9 .pep ·_ j>0 AiaThr ProLeuGlyProAiaSerSerLeuProGlnSerPheLeuLeuLysSerLeuGluGinValArgLysIle GlnGlyAspGlyAiaAlaLeuGlnGluLysLauCysAlaThrTyrLysLeuCysHisProGluGluLeuValLeu LeuGlyHisSerLeuGlyllePrcTrpAlaProLeuSerSerCys ProSerGlnJi-laLeuGlnLeuAlaGlyCys LeuSerGlnLeaHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlr^-IaLeuGluGiyIleSerProGluLeu i _ GlyProThrLeuAspThrLeuGinLeuAspValAlaAspPheAlaT'hrThrneTrpGinGinMetGluGluLeu 35 GlyMecAlaProAlaLeuGlnProThrGInGlyAlaMet?roAla?heAlaSerAla?heGlnArgArgAlaGly GlyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSerTyrArgValLeuArgHisLeuAiaGlnPro TyrVsiGluGlyGlyGiyGlySerPrQGl’/GIliProSerGlyProlieSeirThrIleAsnProSer'PrGProSer*

PheGinHisSer ?roIleSerSerAsp?he AlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrPrc'/alThrValAlaSerAsnLeuGlnAsp

SerLysMecGinGiyLeuLeuGluArgVaiAsnThrGluIleHisPheValThrLysCysAlaPheGlnProPro ProSerCysLeuAirgPheValGLnThrAsriIleSerArgLeuLeuGInGiuT'hr'SerGluGInLeuValAiaLeii LysProTrpIl_sThrArgGlriAsri?heSerAraCvsLeuGluLeuGlnCvsGlri?roAsoSerSer1：hrLeu SEQ ID NO：653 … 45 pMON-3 217 3 .pep

AlaThrGlrJ\spCysSer PheGlnHisSer Prol ieSerSerAsp?heAlavralLys IleArgG LuLeuSerAsp __ TyrLeuLeuGlaAspTyrProValThrValAiaSerAsnLeuGlrL^spGiuGluLeuCysGlyGlyLsuTrpArg

50 LeuValLeuAlaGlnArgTrpMetGiuXrgLeuLysThrValAiaGlySerLysMecGlnGlyLeuLeuGiuArg V a 1A s η T h r G1 u I i e H i s P h e V* a 1T h r L y s C y s ΛI a ? h e G i η P r ο P r o ? r o S e r C y 5 L e u A r g ? h e v* a 1G i r：T h r As ri 11 e S e r Ar g Leu LeuG i nG i uTh r S erGl uG 1 nLeu Va 1A i aLeuLy s P r οΊ1 r p 工 i eT hr Ar gG 丄 riAs n ? he SerArgCysLeuGluLeuGir.CysGlnProAspSerSerThrLeuTyrVaiGIuGiyGiyGlyGlySerPrcGly —· GiuProSerGIyProIleSerThr IleAsnProSer?ro?roSerLysGiuSerHisLys5er?roAsn：-IetAla 55 ThrGInAspCysSerPheGlnHisSerProIIeSerSerAspPheAiavaiLysIleArgGiuLeuSerAscTyr L e u L e uG 1 π A s pTy r ? r ο V a i T h r V a IAI a S e r A s n L e uG 1 nA s p GI '-G i uL e uC y 3 G i y G1 y L e uT r p Ar a L e u Va 1LeuAi aG 1 iiAr gT rpMe cG 1 uArg LeuLy sT hrVa iΛ1 aG 1 y Ser Ly 3Me cG i r.G 1 y LeuLeuG 1 uArgVa I AsnThrGluIleHisPheVaiThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsn 11 e S e r· Ar g L e u L e uG i p‘G _L uT h:: S e rG i uG i nL e u Va ]_ A1 a L eu Lz/s ? rroT r ρ I i-sThr· Ar gG i nAs π P h e S e r* 60 ArgCys LeuGluLeuGlriCysGlnProAspSer SerThr Leu SEQ ID MO :654 PMOM32175.pep

AlaThrGinAspCysSerPh.eGInHisSerProlieSerSerAspPheAlaVaiLyslieArgGluLeuSeirAsp 65 TyrLeuLeuGlrL^spTyrProValThrValAlaSerAsnLeuGinAspGluGluLeuCysGlyGLyLeuTrpArq LeuValLeuAiaGinArgTrpMetGluArciLeuLysThrVaiAlaGlySeirLysMetiGinC-iyLeuLeuGiuAr'g ValA3nThrGIuIIeHisPheVaiThrLy3Cy〇Ala?heGIn?ro?r〇?roSerCysLeuArg?heValGlnThr AsnlieSerArgLeuLeuGinGluT'hrSerGiuGLnLeu'/aiALaLeuLysProTrpIle'rhrArgGlrrAsnPhe SerArgCysLeuGluLeuGinCysGInProAspSerSerThrLeuTyrValGluGlyGIyGlyGiySerProGl·/ 70 G luPrrcSerJ 丄:/Pro UisL'/sSerPiroAsaMetAia

TlirPi:cLJeuGi：/?r'〇AiciSerSerLJeu?roGLnSerPheLe，jLeuLv.sC’/sLeuGiuGinValArgLysIl-jdri

Gl'/AspGL'/AiaAidLeuGLnGLuI^/sLeuCysAlaThrTyirLysLeuC'/sHisPirGGiuGluLeuValLeuLeu

SerG inLeuH l3SerG L./Leu?heLeuTyrdnG l'/LeuLeuGirLALaLeuGiLiGiy 工 leSer ProGiuLeuG iy 75 ProThrLeuAspThrLeuGlnLea^spValAlaAspPheAidThrThrlleTrpGlnGlai-iecGluGluLeuGl/ O:\92\92747.DOC -238 - 200413407

MetAlaPrcAiaLeuGlnProThrGlnGl'/AlaMecProAlaPheAJLaSeirAiaP'neGlnArgArgAiaGl'/Gi'/ ValLeuValALaSerHisLeuGlr.SerPheLeuGiuValSerTyrArgVaiLeuArgHisLeuAlaGlnPro SEQ ID MO：655 ‘ 5 pMOM32204.pep

AiaThrProLeuGlyProAIaSerSerLeuProGlnSerPheLeuLeuLysSerLeuGiuGlnValArgLyslie GlnGl'/AspGiyAlaAlaLeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHis ProGiuGiuLeuVa LLeu LeuGlyHisSerLeuGlylleProTrpAiaProLeuSerSerCys ProSerGinAlaLeuGlnLeuAlaGlyCys

GlyProThrLeuAspThrLeuGlnLeuAspValAlaiAspiPheMaThrThr I ieTrpGlnGlnuMetGiuGluLeu GlyMetAla?roAlaLeuGLn?ro.ThrGlnGlyAlaMet:ProAlaPheAlaSerAlaPheGlnArgAxgAlaGiy GlyValLeuVaiAlaSerHisLeuGinSerPheLeuGluValSerTyrArgValLeuArgHisLeuAlaGlnPro TyrValGluGlyGlyGl'/Gl’/SerProGlyGluProSerGlyProIleSerThr I leAsnProSerProProSer i 5 LysGluSerHisLysSerPrcAsni-ietAlaThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPhe AlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAsp GluGluLeuCysGlyGIyLeuTrpArgLeuVaiLeuAlaGlnArgTrpMetGiuArgLeuLysThrVaiAlaGiy

ProSerCysLeuArgPheValGlnThrAsn工 ieSerArgLeuLeuGlnGluThrSerGiuGlnLeuVaiAlaLeu 20 LysPr〇TrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlr‘CysGln?roAspSerSerThrLeuTyr ValGluGl;/GiyGlyGlySer?roGlyGluProSerGl:/Pro：： leSerThrl leAsnProSerPro?r:oSerLys GluSerHisLysSerProAsoMecAiaThrGiaAspCysSerPheGlnHisSerProIieSerSerAsoPheAla Va lLys I leArgGl’dlieuSerAspTyrLeuLeuGlnAspTyrProValThrVa 111 _ GluLeuCysGlyGiyLeuTrpArgLeuValLeuAlaGInArgTrpMetGluArgLeuLysThrValAlaGlySer 25 LysMe tGlnGlyLeuLeuGlLiArgValAsriThrGiuIleHis Phe'/alThrLysCysAiaPheGlnProProPro

SerCysLeuArgPheVaiGlnThrAsnlleSerArgLeuLeuGlnGluThrSerGluGlnLeu'/aJLAlaLeiiLys ProTrpIleThrArgGlrJ\3n?heSerArgCysLeuGluLeuGlnCvsGin?roAsOSerSerThrLeu SEQ ID NO :655 ' 30 pMON3 2 20 5. pep

AlaAsnCysSerIleMetlieAspGIuIIelleHisHisLeuLysArgProProAlaProLeuLeuAsOPrcAsn Α5ηΕθΐιΑ3ηΛ；2ρ01ιιΑ3ρν^Ξΐ5<Β2Γΐ leLeuMetAspArgAsnLeuArgLeuProAsnLeuGluSerPheValArg ” AlaValLysAsnLeuGluAsnAlaSerGly二leGluAlaIleLeuArgAsnLeuGln?r〇CysLeu?roSerAla 35 ThrAlaAla?roSerArgHis ?Γ〇Ι1θΙ1θΙ1θΙ^5Αΐώ01'/Α3ρΤι:ρΟΐΓ^31ι_ιΡ]ΐθΑΓ9〇1’αΙ^5ΐ^ιιΊ^2： Phe TyrLeuValThrLeuGluGlnAlaGlnGiuGlnGlnTyrValGluGiyGlyGlyGlySerProGlyGluProSer GlyProI leSerThrl leAsnProSerProProSerLysGluSerHisLysSerProAsnl-ietAiaThrGinAsp CysSer?heGlnHi3Ser ?::〇 I leSerSerAspPheAlaValLys IleArgGluLeuSerAspTyrLeuIjeiiGin AspTyrProValThrValAlaSerAsnLeuGInAspGIuGiuLeuCysGlyGlyLeuTrpArgLeuValLeuAia

IleHisPhe'/alThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnlleSerArg LeuLeuGlr^GluThrSerGiuGinLeuValAiaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeu GluLeuGlr-.CysGlnPrcAspSerSerThrLeuTyrValGluGIyGiyGlyGlySer ProGiyGluProSerGly _ Prol leSerThr 工 leAsnProSeirPiroProSeirLysGluSerHisLysSerPrQAsrLMetAiaThrGinAspC’/s 45 SerPheGlnHisSerProlLeSerSerAspPheAiaValLysIleArgGluLeuSerAspT'/rLeuLeuGlnAsp

TyrProValThrValAIaSerAsnLeuGln-\spGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGin ArgTrpMe CGiuArgLeuLysThrValAlaLGlySerLysMetGinGlyljeuIjeuGluArgVaiAsnThrGiuIle His PheValThirLy sCys Ala PheGlnPro Pro ProS erCysLeuArgPheValGin.ThrAsnlleSerArgLeu LeuGlnGluThrSerGlLiGlnLeuVal^laLeuIjysPro.TirpIieThrArgGiaAsnPheSerArgCysLeuGlu 50 LeuGlnCysGlnProAspSerSerThrLeu SEQ ID ΙίΟ :657 PMON32203.cep

AlaThrGln-二.spCysSer PheGlr.HisSer Pro 二]_eSerSer AspPheAlaVaiLys 工 IsArgGluLeuSerAsp 55 TyrLeuLeuGlr^spTyrProVaiThrValAlaSerAsnLeuGiaAspGiuGluLeuCysGIyGlyLeuTrpArg Leu Va 1L e u AI aG I nAr gT r c Ma t:G1 uAr g L euLy sThr Va 1Λ i aG i y 5 e r Ly s Me cG1 r*G 1 y L e u L e uG i uAr g 7a1As nT h rG i uIi e H i s ? h eVa i T h r Ly s C y s A1a P h eG1n ? r o ?r o ? r o S e rCy 5 L e uAr g ? h eVa i G1nT h r AsnlLeSerArqLeuLeuGInGluThrSerGiuGlnLeuValAlaLeuLys ProTrpIieThrArgGlrL^snPhe SerArgCys LeuGIuLeuG inCysGIn P roAspSerSerThr LeuTyrVa1GluGIvGlyGlyGlySer ProG iy 60 GluProSerGLyPiro IleSerTArlieAsnProSer ProProSerLysGiuSerHisLysSerProAsoMetiAld ThrProLeuGIvProAlaSerSerLeuPrcGlnSerPheLeuLeuLysSerLeuGluGlnValArgLysIleGin GlyAspGiyAiaAlaLeuGir/GluLysLeuCysAlaThrTyrLysLeuC^sHisProGluGIuLeuValLeuLeu GlyHisSerLeuGiylleProTroAlaProLeuSerSerCysProSerGlnAlaLeuGlnLeuAiaGlyCyoLeu SerrGinLeuHisSerGiyLeuPheLeuTyrGlnGii/LeuLeuGlnAlaLeuGiLiGiy I leSer ProG丄 uLeuG 丄./ 65 ProThrLeuAspThrLeuGinLe'aAspValAlaAspPheAiaThrThr IleTrpGlnGlruMe CGluGluLeuGly

Me t A 丄 a P l- o A1 a L e uG 1 n ?二-ο T h rG 1 nG 1 y A1 a Me C P r cAi a P e A i a S e r A 丄 a P h eG Hr gA r g A1 aG 1 yG 1 y ValLeuValAiaSerHisLeuGlnSerPheLeuGluValSerTyrArgValLeuArgHisLeuAlaGlnProTyr '/alG luG LyG i’/G L’/Gi’/SerProG LyG LuPrcSerGl，：/?rc lleSerThr I

GluSerH is LysSer PrcAsp.MecAlaThrGiaAspCysSerPheGinHisSer ProIleSerSeirAspPheAia

70 ValL’/s l 丄uLeuSerAspT'/TLeuLeuG

GLuLeuC'/sG LyG LyLeuTrpArgLeuVaiLeuAlaG InAr g.T'irpMetGJLuArgLeuLys'ThrValAldGi'/Ser LysMe tG1 r.G iyLeuLeuGiuArgVaiAsnThrGluIleHis PheValThrLysCysAiaPheGlnProProPr 〇 SerCy：s LeuArq PheVa LG InThrAsnl leSerArgLeuLeuG LaG luThr SerGluG lriLeuVal AiaLeuLys ProTrplie rhrArqGiaAsnPKeSerArqCysLeuGluLeuGInCysGinProAspSerSerThrLeu SEQ 75 ID NO: HR •239-

O:\92\92747.DOC 200413407 pMON3 57 67. pep/pMOM3 2191. pep

AlaThrSlnAspCysSerPheGlnHioSerProlleSerSerAspPheAiaVaiLysIleArgGluLeuSerAsp 5 TyrLeuLeuGlaAspTyrProVaiThrValAlaSerAsnLeuGlnAspGluGiuLeuCysGlyGlyLeuTrpArg LeuValLeuAlaGlaArgTrpMetGluArgLeuLysThrValAXaGlySerLysMetGInGlvLeuLeuGluArg ValAsaThrGluIleHisPheValThrLysCysAiaPheGInProProProserCysLeuArgPheValGlnThr AsnlleSsrArgLeuLeuG LnGluThrSerGluGinLeuValAlaLeuLysProTrpIleThrArgGlnAsnPhe SerArgCvsLeuGiuLeuGInCysGlnProAspSerSerThrLeuTyrVaiGluGlyGlyGlyGlySerProGly 10 GivGiySerGlyG I'/GlvSerAsniMe tAlaThr ProLeuGiyProAlaSerSerLeuProGInSerPheLeuLeu

LysSerLeuGIuGlnValArgLys ΓleGlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrTyrLys LeuCysHis ProGluGiuLeuValLeuLeuGlyHisSerLeuGlyIle?roTrpAla?roLeuSerSerCys Pro S erG i nA 1 a L euG i r*L euA 1 aG lyCy s Leu S e rG 1 nLeuH i s SerG 1 y L eu ? he L euTy rG 1 nG lv LeuLeuG 1 n AlaLeuGluGly IleS er ProG luLeuGly?roThrLeuAspThrLeuGlnLeuAspValAlaAsp?heAlaThr 1 5 ThrIleTrpGlnGlni4etGluGluLeuGIyMetAlaProAlaLeuGinProThrGlnGiyAiaMetProAlaPhe A1 aSer A1 a ?heG 1 nAr gArgA1 aG I yG I y Va i L eu Va i A1 aSer H i s LeuG 1 r.S er PheL euG 1 uVa 1Se rTy r ArgVaiLeuArgHisLeuAiaGlnPro SEQ ID NO :659 ^ 20 pMON3 2 3 97. pep

AlaAsnC'/sSerrI ieMetl leAspGlu工 lei leHisHisLeuLysArg?:ro?roAsnProLeuLeuAsp)P:r〇Asn AsnLeuAsnSerGluAspMeCAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeuAlaPheVaiArg AlaValLysHisLeuGluAsnAlaSerGLyl 25 ThrAlaAiaProSerArgHisProIlellelleLysAlaGl'/AspTrpGlnGluPheArgGiuLysLeuThrPhe Ty r L euVa IT hr L euG 1. uG 1 nAl aG InG 1 uG 1 nG InTy rV a iG i uG 1 yG 1 yG 1 yG i y S er P r oG 1 yG lu P r o S e r GlyProIleSerThrlleAsnProSerProProSerLysGluSerHisLysSerProAsnMecAlaAspTyrPro ValThrValAlaSerAsnLeuGInAspGluGIuLeuCysGlyGl/LeuTrpArgLeuValLeuAlaGlriArgTrp MetGiuArgLeuLysThrVaiAiaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHis Phe 30 ValThrLysCysAlaPheGInProProProSerCysLeuArgPheValGlnThrAsnlleSerArgLeuLeuGin GluThrSsrGiuGinLe'j.ValAiaLeuLy5?roTrpIleThrArgGliiA3n?heSerArgCy3LeuGluLeuGIn CysGlnProAspSerSerThrLeuGlyGlyGlySerGiyGlyGiySerGiyGiyThrGlnAspCysSerPheGln HisSerProIieSerSerAspPheAlaValL/sIleArgGluLeuSerAsoTyrLeuLeuGIn. SEQ ID NO:660 、 35 pMON3 23 9 3. pep

AlaAsnCysSer I leMetl LeAspGiuIieIleHisHisLeuLys‘\rgPro?roAsnProLeuLeuAspProAsn AsnLeuAsnSerGluAspLMecAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeuAiaPheValArg 40 AlaValLysHisLeuGluAsnAlaSerGiylleGiuAlal leLeuArgAsr.LeuGlnProCysLeuProSerAla iel lei LeLysAlaGlyAspTrpGlr.GluPheArgGiuLysLeuThrPhe TyrLeuV 云 iThrLeuGluGlnAlaGlnGluGlnGlnTyr'/alGluGiyGiyGlyGlySerProGiyGiuProSer GlyProI leSerThr IleAsnProSerProProSerLysGluSeirHisLvsSerPrcAsnMecAlaAspTyr?!':：) _ ValThrValAlaSerAsnLeuGinAspGIuGluLeuCysGlyGiyLeuTrpArgLeuValLeuAlaGlriArgTrp 45 MetGluArgLeuLysThrVaiA1aGlySerLvsMetGInGlyLeuLeuGluArgValAsnThrGluIleHisPhe

GluThrSerGIuGlr.LeuValAlaLeuLysProTrpIleThrArgGlriAsnPheSerArgCysLeuGluLeuGln C y s GI n ? r o As p S e r S e rT h r L e uG i yG 1 yGI y S e rG1 yGI yG 1 y S e rGI yGI yG1 y S e rGI yGI yG1 yT h r G1 n AspCysSerPheGlnHisSerPrcIiegerSeirAspPheAlaVaiLysIieArgGiuLieuSerAspTyrLeuLeu 50 Gin SEQ ：D MC:661 " ' pMOM3 2 3 9 9. pep

AlaAsnCysSer I ieMe 11 LeAspGluI lei ieHisHisLeuLysArgProProAsnProLeuLeuAspPrcAsn 55 AsnLeuAsnSerGl'-iAspMetAspI ieLauMe tGluArgAsnLeuArgThr ProAsnLeuLeuAlaPheValArg

AiaV'a iLysHisLeuGluAsnAlaSerGly I leGluAial leLeuArgAspxLeuGir.ProCysLeuProSerAid ThrAlaAiaProSerArgHis ProlleiislLeLysAiaG LyAspTrpGlr.GiuPhsArgGluLysLeuThrPhe Ty r Le u Va 1T h r L euG 1 uG i nA 1 aG 1 nG 1 uG I nG 1 nTy r Va 1GI uG 1 yG 1 yG i yGI y Se r P r oG 1 yG I u Pr o S e r GiyPro I ieSerThr I ieAsnProSer ProProSerLysGiuSerHisLysSerProAsnl^etAlaAlaSerAsn 60 LeuGip^spGluG luLeuCysGlyGlyLeuTrpArgLeuV'aiLeuAiaGlnArgTrpMecGiuArgLeuLysThr ValAlaGiySerLysMecGlnGlyLeuLeuGluArgValAsnThrGluI leHis PheValThrLysCysAlaPhe GlnPi:o?r.::‘？roSerCysLeuArg?heVaiGlnThrAsnI leSerArgLeuLeuGlr.GluThrSerGluGlnLeu VaLAlaLeuLys ?ro.TrpI leThrArgGlnAsnPheSeirArgCysLeLiGlluLeuGlnCysGlnProAspSerSer ThrLeuGiyG iyGiySerG LyGlyGlvSerGLyGlyThrGlnAspCysSer PheGLaHisSerProIleSerSer 65 A3pPheALaVraiiLys I ieArgGiuLeuSerAspTyrLeuL丑ιι01·πΑ；3ρΤ;/：Γ?：Γ〇ν&1ΤϊΐΓ·ν3ΐ SEQ ID MO：6 b 2 〇MOM3 5- 0 0 . cep 70 Ai^AsnCyoSerlieMeriieAspGIuIielleHisHisLeuLysArgProProAsnProLeuLeuAjpProAon AsnLeuAsnSerGIuAspMecAspIleLeuMetGluArgAsnLeuArgThi-proAsnLeuLeuAiaPheValArq A 丄丄二·/j H LeuG LuAsnALaSerGi vdeGiuAial ieLieuArgAsnLeuGiriPiroCysLteuProSerAia

ThrAidAlaProSerArqHis Pro IlelielleLysAlaGlyAspTrpGlnGluPheArgGiuLysLeuThrPhe Ty r Leu.·/a i T h‘:: L euG 1 ud nA 丄 aCM nG L uG i nG 1 n*T，/ r'/a LG i uG i yG i，.，G 丄 y，] i yS e:: P::〇G 1 yG 1 u P r 〇 S e r: 75 GlyPro1leSerThrIieAsnProSerProProSerLysGluSerHisLysSerProAsnKecAiaAlaSerAsn -240-

O:\92\92747.DOC 200413407

LeuG 1ηΑ5ρΟ1ιιΟ1υΙ^θυ(Τ，_/3〇1^/Ο1·ν.Ι·ι«0ΐιΤΓ·ρΑι：3ΐ>0αν3ΛΙ^θαΑΐ2ΐΟΐΓΐΑ:：9Τϊ：ρΜθ!：Ο1ι：ΑΓς!^θ\ι!^γ·5Τΐι:： ValAiaG LySerLysMetGlnGlyLeuLeuGluArgValAsnThrGlulleHis PheValThrLysCysAlaPhe GlnProP-roProSerC'/sLeuArgPheValGinThrAsnl leSerArgLeuijeuGlnG.'LuThrSerGluGlnLeu ValAIaLeuLys ProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGInCysGlnProAspSerSer 5 ThrLeuGlyGiyGlySerGlyGlyGlySerGiyGlyGlySerGlyGiyGlyThrGlnAspC'/sSerPheGlnHis SerProIleSerSerAspPheAlaVaiL7SIleArgGluLeuSerAspTyrLeuLeuGlnA5pTyrProValThr Val SEQ ID MO：563 pMCN3 57 01.oeo 10 ^ ΑΐΑΑ5ηΟ;/3 3θΐ·Ιΐ0Μθϊ：Ι]_<5Α3ρΟ1ιιΙ1θΠ·βΗί3Ηί5!^βιαΙγ：3ΑΓ9Ρ2：οΡ::〇Α5ηΡΓ〇Ι^0υί^θΐαΑ5ρΡι:οΑ5η

AsnLeuAsnSerGiuAspMetAspileLeuMetGluArgAsnLeuArgThrPrOAsnLeuLeuAlaPheValArg AlaValLysHisLeuGluAsnAlaSerGlylleGluAlalleLeuArgAsaLeuGlnProCysLeuProSerAia ThrAlaAiaProSerArgHis ProllellelleLysAiaGlyAspTrpGlnGluPheArgGluLysLeuThr?he 15 TyrLeuValThrLeuGluGIru\laGlnGluGlnGirLTyrValGluGlyGiyGlyGlySerProGiyGIuProSer GlyProIleSerThrXieAsr*?roSer?roProSerLysGiuSerHisIJysSerProAsnHetAlaVaiAlaGly SerLvsMecGlnGlyLeuLeuGluArgValAsnThrGluILeHisPheValThrLysCysAiaPheGlnProPro ProSerCysLeuArgPheValGlnThrAsnlleSerArgLeuLeuGlnGlirThrSerGluGlnLeuV^lAlaLeu Lys ProTrpIleThrArgGlnAsnPheSerArgCysLeuGiuLeuGlnCysGlnProAspSerSerThrLeuGiv 20 GlyGlySerGlyGlyGlySerGlyGlyThrGInAspCysSerPheGlnHisSerProIleSerSerAspPhsAia ValLys I leArgGluLeuSer'AspTyrLeuLeuGlnAspTyrPro'/alThr'/alAlaSerAsnLeuGlnAspGlu NO:654 — ‘ ^

25 pMON35702.pep

AlaAsnCysSer lieMetlleAspGluIlelleHisHisLeuLi'/sArgPrcProAsnPrrcLeuLeuAspProAsn

AsnlieuAsriSeirGiuAspMe tAspI leLeuMe 匚GluArgAsnLeuArgThrProAsnLeuLeuAlaPheValAirg i AlaValLysHisLeuGluAsnAlaSerGlyIleGluAlalleLeuArgAsnLeuGlnProCy.sLeuProSerAld 30 ThrAlaAlaProSerArgHisProIlallelleLysAiaGlyAspTrpGlnGIuPheArgGluLysLeuThrPhe TyrLeuVaiThrLeuGluGlnAlaGlnGluGlnGlnTyrVaiGiuGlyGlyGlyGlySerProGi/GluProSer GlyProlieSerThrIleAsnProSerPrcProSerLysGiuSerHisLysSerProAsnxMetAlaVaiAlaGIy SerLysMetGlnGlyLeuLeuGluArgValAsnThrGiuIleHisPhevklThrLysCysAlaPheGlnProPro i ProSerCysLeuArgPhe'/alGlnThrAsnlleSerArgLeuLeuGlnGluThrsirGiuGlnLeuV.alAlaLeu 35 LysProTrpIIeThrArgGlnAsnPheSerArgCysLeuGluLeuGinCysGInProAspSerSerTarLeuGly GlyGlySerGIyGlyGlySerGlyGlyGiySerGlyGlyGlyThrGinAspCysSerPheGlnHisSerProIIe SerSerAspPheAlaValLysIleArgGluLeuSerAspTy^LeuLeuGliiA^pTyrProV’alThrValAlaSer As n L· e uG 1 nA s pG 1 uG i u L e uC· y s G1 y G1 y L e u.T r Ό A r g L e u V aiLeuAla_Gl nAr gT ϊΓΌ M e tG 1 u Ar g L e u L v s Thr SEQ ID NO :665 ‘ " ^ 40 PMOM25703.pep A1 aAsnCy s 3 e r11eMe 111eAs pG1u11e11eH i s H i s Le uLys Ar g P r o ? r oAsn ? r o Le uLe uAsp ? r oAs n • AsnLeuAsnSerGluAsijMecAspIleLeuMecGluArgAsnLeuArgThrProAsnLeuLeuAlaPheValArg 45 AlaVaxLvsHisLeuGluAsnAiaSerGlyIleGiuAlalieLeuAraAsnLeuGlnProCysLeuProSerAla

ThrAlaAlaProSerArgHisProIlellelleLysiUaGlyAsO.TriGlnGluPheArgG'iuLysLeiiThrPbie TyrLeuValThrLeuGluGlrJUaGlnGluGlnGInTyrValGiuGlyGlyGiyGl'/SerPrcGlyGiuProSer GlyProu.eSerThrileAsnProSerProProSerLysGIuSerHisLvsSerProAsnMetAlaArgPheVai GlnThrAsnlleSerArgLeuLeuGinGluThrSerGIuGlnLeuValAiaLeuLysProTroIleThrArgGIn D〇 AsnPheSerArgCysLeuLiluLeuGlnCysGInProAspSerSerThrLeuGlyGiyGIvSerGlyGlyGlySer

GlyGiyThrGlnAspLysberPheGlnHisSerProIleSerSerAspPheAlaValLysILeArgGIuLeuSer AspTyrLeuLeuGlnAspTyrProValThrVaiAiaSerAsnLeuGinAspGIuGiuLeuCysGlyGlyLeuTrp n.rgLeuvalLeuAlaGlr^\rgTrpMet:GluArgLeuLy3ThrVaiAiaGlySerLy3MecGlaGlyLeuLeuG iu ArgValA^rt i hrGlu j. Ιθηis -^ThrLiVsCysAlaPhsGInProPrc ProSerCvsLeu S5Q ID 55 MO： 666 ·* pMOM3 57 0 4. pep 60 AlaAsnCysSer 11 eMe Cl leAspGluI iej.leHi.3H isLeuLvsArg ProProAsnProLeuLeuAsDProAsa

AsnLeuAsnSerGluAspMecAspIieLeuMetGluArgAsnLeuArgThr?roAsnLeuLeuAla?heValArg AlaVa iLysHis 〇euG luAsn^MaSerG iy I leG luAial ieLeuArgAsULeuGlnProCysLeuProSerAla ThrAlaAiaProSerArgHis ProI j.elleIieLysAlaGlyAspTrpGinGluPheArgGluLysLeuThrPho • TyrLeuValThrLeuGluGlnAlaGlnGluGinGlnTyrVaiGluGlyGlyGiyGlySerProGlyGluProSer 65 GlyProIieSe rT ^-H'SAsnProSerProProSerLysGluSerHis Ly s S e r P r o As riMe t: A1 a Ar g Phe Va I

GlnThrAsnlieSerArgLeuLeuGlnGiuThrSerGluGInLeuValAiaLeuLysProTrpIleThrArgGLn AsnPheSerArgCysLeuGLuLeuGlaCysGinProAspSerSerThrLeuGiyGiyGlySerGlyGlyGlySer G ^ yG L yG 1 '/S e r〇 1 yo x yu ^ yT hr^r 1 r\As pC y s S e r P heG L nH isSerProIIeSerS e r As p Ph e A1 a Va i Ly 〇 rieArgGLuLeuSerAspTyrLeuLeuGIp^spTyrProValThrVaiAlaSerAsnLeuGlriAspGluGluLeu 70 Cj sGl /〇x v u rrpArg^euValLeuAlaGinArgTrpMe cGIuArgLeuLysThrValAlaGlySerL/sMet:

GmG^/LeuLeuGlu.-\rgVaI.\snThrbi.u I IeH is Phe ValThrLvsCvs Aid PheG In Pro Pro ProSerC vs

Leu S二Q ID ^ · pMON35705.oep 75 ‘ O:\92\92747.DOC 241 - 200413407

AlaAsnCysSerlleMetlieAspGluIielieHis-KisLeuLysArgPrQproAsnProLeuLeuAspPrcAsn AsnLeuAsnSerGluAspMetAsp I leLeuMecGluArgAsnLeuArgThr'ProAsnLeuLeuAliaPheValArg AlaValLysHisLeuGluAspJUaSerGlylleGiuAlalleLeuArgAsnLeuGinProCysLeuProSerAla ThrAlaAlaProSerArgHisProI丄elielleLysAlaGlyAspTrpGlnGiiiPheArgGluLysLeuThrPhe 5 TyrLeuVaiThrrLeuGluGlnAlaGlnGluGlnGlnTyr'/alGLuGlyGiyGl'/SerSerProGlyGiuProSer GiyProIleSerThrIleAsnProSerProProSerLysGLuSerHisLysSerProAsr^MetAlaThrAsnlie SerArgLeuLeuGlnGluThrSerGiuGlaLeuVaiAlaLeuLysProTrpIleThrArgGlriAsnPheSerArg CysLeuGluLeuGinCysGinProAspSerSerThrLeuGlyGlyGlySerGiyGlyGlySerGlyGlyThrGIn AspCysSerPheGInHisSerProIleSerSerAspPheAlaVaiLys!leArgGiuLeuSerAspTyrLeuLeu 10 〇1ηΑ5ρΤγΓ?][：〇ν3ΐΤΗ::\/3ΐΑΐΑ3β；ΓΑ3ηΙθΐι01ηΑ3ρ〇]<ιι〇1ιαΙ>Θΐ·Κ：'/5〇1'/01'/ΙίβαΤΓρΑ2：9ί^βιιν^ 丄 Leu

AlaGlnArgTrpMecGluArgLeuLysThrValAlaGlySerLysMetGinGlyLeuLeuGluArgValAsnThr GluIleHisPheVaiThrLysCysA丄aPh.eGlnProProProSerCysLeLLAirgPheValGLn SEQ ID NO :563 ^ 15 pM〇M35706.pep

AiaAsnCysSerIleMecIieAspGIuIIelleHisHisLeuLysArgProProAsnProLeuLeuAspProAsn AsnLeuAsnSerGluAspMetAspIleLeuMeCGiuArgAsnLeuArgThr?roA3nLeu.LeuAla?heVaiArg AlaValLysHisLeuGiuAsnAlaSerGly I： leGluAla工 leLeuArgAsnLeuGlnProCysLeiiProSerAia -〇 ThrAlaAlaProSerArgHisProIleIleIIeLysAlaGlyA〇pTrpGinGlu?heArgGluLysLeuThr?he TyrLeuValThrLeuGiuGir^IaGinGiuGinGinTyrValGiuGlyGlvGiyGlySerProGiyGluProSer GlyProIleSerThirneAsnPr'oSerProPiroSeirLysGiuSerHisLy-SeirPriAsrLMetAlkT'hrAsnne SerArgLeuLeuGlnGluThrSerGluGInLeuValAiaLeuLysProTrpIieThrArgGlnAsnPheSer'Arg 讀 CysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGiyGlySerGlyGlyGlySer -5 GlyGlyGlyThrGlnAspCysSerPlieGInHisSerProIleSerSerAspPhsAlaValLysIIeArgGIuLeu SerAsplyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeu TrpArgLeuValLeuAlaGlrJ^rgTrpMstGluArgLeuLysThrVaiAlaGlySerLysMecGIr.GlyLeuLeu GluArgVaiAsnThrGluIIeHisPheVaiThrLysCvsAlaPheGlnProProProSerCvsLe-AraPheVai Gin SEQ ID MO：559 30 pMON35733.pep

AiaAsnCysSerIleMetIleAspGluIleileHisHisLeuLysArgProProAsnProLeuLeuAspProAsn AsnLeuAsnSerGluAspMetAspIIeLeuMetGIuArgAsnLeuArgThrProAsnLeuLeuAlaPheValArg j5 AlaValLysHisLeuGluAsnAlaSerGIyllsGiuAIalleLeuArgAsnLeuGlniProCysLeuProSerAia ThrAlaAlaProSerArgHisProIlelleriGLysAlaGiyAspTrpGlnGiuPheArgGluLysLeuThrPhe TyrLeuValThrLeuGluGir^laGlriGluGlnGlnTyryaiGluGlyGlyGlyGlySerProGlyGluProSer GlyPro IleSerThr I leAsnProSerProProSerLysGluSerHisLysSerProAsrJ-letAlaSerAsnLeu GlnAspGiuGluLeuCysGiyGlyLeuTrpArgLeuValLeuAIaGInArgTrpMetGiuArgLeuLysThrVai 40 AlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAiaPheGLn ProProProSerCysLeuArgPheVaiGlnThrAsnlleSerArgLeuLeuGlnGluThrSGrGluGlnLeuVai AlaLeuLysProTrpne-ThrArgGinAsnPheSerAirgCYsLeuGiLiLeuGinCysGlnProAspSerSer.rhE· LeuGlyGlyGlySerGlyGiyGiySerGlyGlyGiySerGiYGiyGlySerGlvGiyGiySerGlyThrGinAsp CysSer?heGlnHisSer?roIIeSerSerAsp?heAiaVaiLysIIeArgGluLeuSerAsr)TvrLeuLeuG：n 45 AspTyrProVaiThrVaiAia SEQ ID NO :570 PMON35734.pep

AiaAsnCysSer I ieMec I I leHisHis LeuLysArg Pro ?rcAsnProL<eiiLieuAsp?rcA_sn 50 Α5ηΐ0ΐιΑ3η3θΓ〇1υ·Α13ρΜβ=‘:\3ρΙ1β^0ϋ·Μ·8ί：〇·Ι，·ν：Αι·9Α3ηΙ^<5^ιΑ:：3ΤΐΛ；τ ProAsnLeuLeuAlaPheV.a LArg

AlaVa iL'/sHisLeuGluAsnAlaSerGiv*]! ieGiuAlal ieLeuArgAsriLeuGlnPrcCysLeuProSerAia ThrAlaAldProSerArgHisProIlenelieLv.sAiaGlyAspTriGinGiuPheArgGiuLysLeuThrPhe TyrLeuvaiThrLeuGiuGinAlaGlnGluGInGlr.TyrVaiGiuGIyGlvGlvGlvSerProGlyGluProSer GlyProrieSerThrneAsnProSerProPrcSerLysGluSerHisLvsSerProAsp^IetAlaAsnLauGir. 55 AspGluGluLeuCysGlyGLyLeuTrpArgLeuVaiLeuAIaGIrL^rciTrcMetGluArgLeuLysThr'/aiAia GiySerLysMetiGinGlyLeuLeuGiuArg'/aiAsrvThrGiuIleHiSph^V-alThirLysCysAiaPheGinPro ProProSerCysLeuArgPheValGlnThrAsnlleSerArgLeuLeuGl-GiuThrSerGiuGlr.LeuVaiAla LeuLys?rcTrprieThrArgGlMsn?heSerArgCysLeuGluLe，jGlnCysGlnProAspSerSerT^^ GlyGiyGiySerGiyGiyGiySerGlyGiyGiySerGlyGlvGlvSerGl'/GlvGlvSerGlvThrGlaAspCys 60 SerPheGlnHisSerProIleSerSerAspPheAiaValLvsIleAraGliiLeuSerAsDTvrLeuLeuGlnAso TyrProValThrVaiAlaSer SEQ ID NO :671 ^ ^ pMON3 57 3 5. pep 、 65 AiaAsnCysSer I ieMetneAspGiu11θηθΗ13Ηί3ΐ^θΐιΙ//ί3Α：Γς?Γ·〇?::οΑ3ηΡϊ：〇ΙθυΙθΐιΑ5ρ?::οΛ5η AsnLeuAsnSrarG I^AspMetAspI leLeuMecG LuArgAsnLeuArg'Thr ProAsnLeuLeuAiaPheValArg P\laT7ai L/./sKisLeuGiuAsnAlaSerGly I ieGiuAlal leLeuAraAsnLeuGLnProCys LeuProSerAia ThrAlaAiaProSerArgHisProIlellelieLysAlaGl/AopTrpGlnGluPheArgGluLysLeuThrPh^ TyrLeuValThrLeuGiuGlaAlaGlnGiuGlaGlnTyrValGluGivGlyGlvGlySerProGlyGluPrcSer 70 Giy?roiieberTh>rrieAsnProSerProProSerLysG：uSerHisLvsS^rProAsnMecAiaLeuGlP^o GiuGLuLe'_:Cy3GiyGiyLeuTrpArgLeuVaiLeuAlaGIr^rgTrr:Mec:GluArgLeuLv3ThrValAiaGly SerLysMetOinGlyLeuLeuGL^ArgValAsnThrGiuIIeHis^heVaiThrLysCysAiaPheGinProPro ProSerCysLeuArgPheViiiGInThrAsnlieSerArgLeuLeuGlnGluThrSerGluGIaLeuValAlaLeu — Lys ProTrp i i'^^^^'^^-^snPheSerArgCysLeuG luLeuG InCysGlnProAspSerSerThrLeuGi / / 5 1^'/^ - rL71V ^ '/^ -'/ -3 e V,(^ l Y'^ - ySer1 yG 1 yG l ySerG 1 vG I yG 1 ySerG i yThrG1 oCv〇 Se r -ΊΑ(λ _ * ‘ ' -242-

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PheGlp.HisSerPro IieSerSerAspPheAlaValLysIieArgGluLeuSerAspTyrLeuLeuGlnAspTyr ProVaiThrVaiAlaSerAsn SSQ ID NO :572 ^ PMON35736.cep 5

AlaAsaCysSerlleMetIleAspGiuIlelleHisHisLeuLysArgProProAsnProLeuLeuAspProAsn AsnLeuAsnSerGiuAspMetAspIleLeuMetGIuArgAsnLeuArgThrPrcAsnLeuLeuAiaPheVaL^rg Ala'/alL'/sHisLeuGluAsnAlaSerGlyIleGluAl«aIleLeuArgAsnLeuGin?roCysLeuPr〇SerAla ThrAlaAlaProSerArgHis Pro IleileileLysAlaGiyAspTrpGlnG LuPheArgGluLysLeuThrPhe 10 TyrLeuVaiThrLeuG1uGIrJVlaG1nG1uG i nGInTyrVaIGIuGIyG1yGIyG1yS e r P rcG1yG i u ?r o S er

GlyPrroI leSerThirl leAsnProSer ProAsnMe tA丄aGinAspGlu

GluLeuCysGlyGlyLeuTrpArgLeuValLeQAlaGinAraTrpMetGluArgLeuLysThrValx^laGlySer LysMetGlnGlyLeuLeuGluArgValAsnThrGluIleKisPheValThrLysCysAlaPheGlaProProPro ^ SerCysLeuArgPheValGlnThrAsnlleSerArgLeuLeuGlnGluThrSerGiuGlnLeuValAiaLeuLys i 5 ProTrpIleThrArgGlaAsnPheSerArgCysLeuGluLeuGlnCysGinProAspSerSerThrLeuGiyGly G1 y S e r G1 y G1 y GI y S e r G1 y G1 yG 1 y S e r GI y GI y G1 y S e r G1 y GI y G1 y S e r G1 yT h rG 1 s p C y s S e r ? h e GlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrPro ValThrValAlaSerAsnLeu SEQ ID NO：〇73 ' ^ 20 ΌΜΟΝ35733.pep

AlaAsnCysSer工leMetlleAspGluIleileHisHisLeuLysArgPrcProAsnProLeuLeuAspPrcAsn AsnLeuAsnSerGiuAspMetAspIIeLeuMecGIuArgAsnLeuArgThrProAsnLeuLeuAlaPheValArg 截 AlaValLysHisLeuGiuAsnAlaSerGlylleGluAlalleLeuArgAsnLeuGinProCysLeuProSerAla 25 ThrAlaAlaProSerArgHisProIlelleileLysAlaGlyAspTrpGlnGluPheArgGluLysLauThrPhe

TyrLeuValThrLeuGluGinAlaGlnGluGlnGlnTyrValGluGlyGiyGlyGlySarProGlyGluProSer GlyProlieSerrThrIleAsnProSerProProSerLysGluSerHisLysSerProAsnMetAlaGluGLuLeu CysGlyGlyLeuTrpArgLeuVaiLeuAlaGlr.ArgTrpMetGiuArgLeuLysThrValAlaGlySerLysMet , GinGlyLeuLeuGluArgValAsnThrGluXleHisPheValThrLysCysAiaPheGlnProProProSerCys 30 LeuArgPheValGlnThirAsnlleSerArgLeuLeuGlnGluThrSerGiuGlnLeuValAlaLeuLysProTrp IleThrArgGlnAsriPheSerArgCysLeuGluLeuGlnCysGinProAspSerSerThrLeuGlyGlyGlySer GlyGlyGlySerGiyGlyGiySerGlyGlvGlySerGlyGlyGiySerGlyThrGlaAspCysSerPheGlnHis SerProIleSerSerAspPheAlaVaiLvsIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThr ” ValAlaSerAsnLeuGLriAsp SEQ IcTn〇:674 35 pMON3 57 3 9. pep

AlaAsnCysSerlleMecIleAspGluIlelleHisHisLeuLysArgProProAsnProLeuLeuAspProA.sn leLeuMetGluAirgAsnLeuAirgThirProAsnLeuLeuAlaPheVaiParg 40 AlaVaiLysHisLeuGluAsoAlaSerGlylleGluAlalleLeuArgAsnLeuGlnProCysLeuProSerAla

ThrAlaAlaProSerAraHisProIlell-alleLvsAlaGLyAspTrpGlnGluPheArgGluLysLeuThrP’ne TyrLeuVaiThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGiySerProGlyGluPrcSer GlyProIie5erThrIleA3nProSer?roProSerLysGlu5erHisLysSerProAsnI4etAlaGluLeuCy3 45 GlyLeuLeuGluArgValAsnThrGluIleHisPhe'/alThrLysCysAlaPheGlnProProProSerCysLeu AirgPiieVaAGliTThrAsnlleSerArgLeuLeuGlnGluThrSerGiLuGlnLeuValAlaLeiiLysProTrpIle ThrArgGlrLA.snPheSerArgCysLeuGluLeuGlnCysGinProAspSerSerThrLeuGlyGlyGlySerGly G1 y G1 y S e r G i y G1 y G1 y S e r G1 y G1 y G1 y S e r G i :/ G1:/ G1:/ S e r G i y T h r G i riA s p C y s S e r P h e G1 η H i s S e r* • ProIleSerSerAspPheAlaVaiLysLleArgGluLeuSerAscTyrLeuLeuGlnAspTyrProValThrVal

50 AlaSerAsnLeuGlr^spGiu SEQ^ID MO：675 pMOM3 57 4 0. pep

AlaAsnCysSerlieMetlleAspGiuIlelieHisHisLeuLysArgProProAsnProLeuLeuAspPrcAsn 55 AsnLeuAsnS-erGiuAspMecAspIleLeuMetGiuArgAsnLeuArgThrProAsnLeuLeuAlaPheVaiArg

AlaVaiLysHisLeuGIuAsnAIaSerGlylleGiuAlalleLeuArgAsnLeuGInProCysLeuProSerAia ThrAlaAiaProSerArgHisProIlelielleLvsAlaGlyAspTrpGlnGluPheArgGiLiLysLeuThrPhe TyrLeuvalThrLeuGluGlnAlaGlnGluGinGinTyrValGluGiyGlyGiyGiySerProGlyGluPrcSer GlyPrc I LeSerThrlieAsnProSerProPiroSerLysGluSerHisLysSeirProAsn^letAiaLeuCysG + y 60 GlyLeuTrpArgLeuVaLLeuAlaGlaArqTrpMecGluArgLeuLysThrValAiaGlySerLysMetGlnGly

LeuLeuGluArgValAsnThrGlulieHisPheValThrLysCysAlaPheGinProProProSerCysLeuArg ?heValGlnThrAsnIisSerArgLeuLeuGlnGluThrSerGluGlnLe.uVaIAiaLeuLys?roTrpIIeThr ArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnPrcAspSerSerThrLeuGlyGlyGlySerGiyGly _ GlySerGlyGLyGLySerGlyGlyGlySerGlyGiyGlySerGlyThrGln^.spCysSerPheGlnHisSerPro 65 I leSerSerAspPheAiaVaiLys 工 leArgGiu乙euSerrAspT'/rLeuLeuGlnAspTyrPro'/alThirVaiAla·

SerAsnLeuGinAspG1uG1u SEQ ID NO：67 6 CMON3S7 41. pep ‘UaAsnCys^rlleMeCleAspGluIlene:七 3!ύ5τυθ」ίγ5ΑΜΡπ?]：〇Α5η?：：.：ίΙ^ΙΐΙ^ΙΐΑ3ρΡ：：。/^ ΛsnLe'J：Λ5Γ.J-rGIϋΛsp^ίecAi；pIleLeuMet：σίLiΛrgAsnL·eϋArgThrProAsΓiL·euLeuAίd?he7aίΛrς ^δ f ^ ° ° ^I uAsnA I a〇erG 1 /1 i eG i uA1 a I i eLeu ArgAs nLeuG 1 η Pr oC vs Lea ?roSe r A1 a ^i；'；^；f-：：〇SerA^Hf3?roi：ieI^neLysAlaGiyA3pTrpGlnGlu?heArgClaLvsLeaThrPhe GivProit^^：i^^：?：^ia?inGiuGinGinTyrVdiGluG^GI/GiV^lySerPrcGIyGiuProSer - x -ProProSerLysGluSerHisL'/sSer ProAsaMecAla3erAspr1pii 70 75 -243 -

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GlrLAspGluGIuLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrVai AlaGiySerLysMetGlnGiyLeuLeuGluArgVaiAsn'ThrGluIleHisPheValThrLysCysAlaPheGln ProProProSerCysLeuArgPheValGlnThrAsnlleSerArgLeuLeiaGinGluThrSerGluGlnLeuVal AiaLeuLys ProTrpIleThrArgGinAsnPheSerArgCysLeuGluLeuGlnCysG LnProAspSerSerThr 5 LeuG 1 yG 1 yG 1 y S e r G1 yG 1 yG lySe rG 1 yG 1 yG 1 vS e rG lyG 1 yG 1 y S e rG lyG 1 yG 1 y S erG lyThrG 1 nAs p

CysSerPheGInHisSerPro IleSerSerAspSerAlaValLysIleArgGiuLeuSerAspTyrLeuLeuGIn AspTyrPrcvalThrValAla SEQ ID N〇：677 ' PMON35742.pep 10

AlaAsnCysSerIleMetlleAspGiu!lelleHisHisLeuLysArgProProAsnProLeuLeuAspProAsn AsnLeuAsnSerGluAspMecAspIieLeuMetGluArgAsnLeuArgThrPrcAsnLeuLeuAlaPheValArg AlaValLysHisLeuGluAsnAlaSerGiylleGluAlalieLeuArgAsnLeuGlnProCysLeuProSerAla ThrAlaAlaProSerArgHis ProlielielleLysAlaGlyAspTrpGln.Giu?heArgGluLysLeuThr?he 15 TyrLeuValThrLeuGluGlnAlaGinGluGlnGinTyrValGluGlyGlyGlyGlySerProGlyGluProSer GlyProI leSerThr I leAsnPrcSerProProSerLysGluSerHisL'/sSerProAsp-MetAlaGlrLAspGlu GluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMecGiuArgLeuLysThrVaiAlaGlySer LysMe tGlnGlyLeuLeuGluArgV’alAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProPiro SerCysLeuArgPheValGlnThrAsril ieSerArgLeuLeuArgGluThrSerGluGlnProValAlaLeuLys 20 ProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGinProAspSerSerThrLeuGIyGly GlySerGlyGlyGlySerGlyGlyGLySerGlyGiyGlySerGlyGiyGlySerGLyThrGinAspCysSerPhe GlnHisSerProI leSerSerAspPheAiaVaiLysIIeArgGiuLeuSerAspTyrLeuLeuGlnAspTyrPro ValThrVaiAlaSerAsnLeu SEQ ID NO：673

25 〇HOM3 57 43. pep

AlaAsnCysSedleMe Cl leAspGluI A5nLeuA3nSerGiuAscMet:AspIieLeuMetGluArgAsn.LeuArgThrProAsnLeuLeuAla?heValArg 、 AlaValLysKisLeuGluAsnAIaSerGlylleGiuAlalleLeuArgAsnLeuGlnPrcCysLeuProSerAla 30 ThrAl¢aAla?roSer1AιrgHisPr〇工ieIle工leLysAlaGl·yAspTrpGlr:Gl·uPheA::gGiuLysLeufΓhr?he Ty r L eu Va 1 Thr L a uG I uG i nA 1 aG I nG I uG 1 nGl nTy r Va IG1 uG 1 yG I yG 1 yG I yS e r ?r oG 1 yG 1 u P ro S e r GlyPro I leSerThr I leAsnProSer ProProSerLysGluSerHisLvsSer ProAsni-letAlaLeuCysGIy G1 y L e uT r p Ar g L eu Va 1L e uA 1 aG I nAr gTr p Me cG i uAr g L euLy s T hr Va 1A1 aG 1 y S e r Ly s Me t G i r*G I y i _ LeuLeuGIuArgVaiAsnThrGluIleHis?heValThrLysCy3AiaPhsGln?ro?ro?roSerCysLeuArg 35 PheVaiGlnThrAsnlleSerArgLeuLeuGlnGluThrSerGiuGlnLeu'/amaijeuLysProTrpIleT'hr

Ar gG 1 nAs n PheS er ArgCysLeuGiuLeuGlnCysArgPrcAspSerSerThr LeuG lyG iyGlyS erG lyG ly G lySerGlyGlyGlySerGiyGlyGlySerGlyGiyGlySerG lyThrG in*\spCysSerPheGlnKis Ser Pro IIsSerSerAspPheAlaValL/sIieArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAia S e r A s n L e uG 1 s pG 1 uG I u SEQ 工 D NO: 679 " "* ' 40 pMON3 2179. pep

AlaAspGiuGluLeuCysGXyGlyLeuTrpArgLeuVaiLeiiAlaGlnArgTrpMetGluArgLeuLysThrVai 45 AlaGlySerLysMetG.LnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGln ProPro?roSerCysLeuArgPheValGlrvThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuVal AlaLeuLysProTrpIieThrArgGinAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThr L e uG i y G1 yG V/ S e rG i yG 1 yG 1 y S e rG 1 yG i yG i y S e r G i yG i yG 1 y S e rG 1 yG i yG 1 y S e rG 1 yT h rG 1 riA 3 p CysSerPheGInHisSerPrQlleSer>SerA.spPheAlaValLys I leArgGluLeuSerAspTyrLeuLeuG In 50 AspTyrProVaiThrValTyrValGluGlyGlyGlyGlySerPrcGiyGluProSerGlyProIleSerThrl la AsnProSerPirc) PrcSerLysGluSerHisLysSerPrcAsoMecAlaAsnCysSer·]； leMe 匚 I ieAspGluI IJLeHisHisLeLiLysArgProProAsnPrcLeuLeuAspProAsnAsnLeuAsnSerGluAspMetAspIleLeu MetGluArgAsnLeuArgThrProAsnLeuLeuAiaPheValArgAlaValLysHisLeuGluAsnAlaSerGly IieGLuAlalleLeuArgAsr.LeuGlnProC/sLeuProSerAlaThrAlaAiaProSerArgHisProIlelle 55 I i e L y s A1 aG L y As pT r pG 1 nG i u P h e A:: gG 1 u L y s L e uT h r P h e‘T?y r L e u'/a 1T h r Ij e uG 1 uG 1 nA 丄 aG 1 nG 1 u

GlnGin SEQ ID MO :680 “ * pMON3 57 07. pep ' 60 AiaAspGluGluLeuCysGlyGlyLeuTrpArgLeuVaiLeuAlaGinArgTrpMeCGiuArgLeuLysThrVal AlaGLySerLysMetGlnGlyLeuLeuGluArgVaiAsnThrGluIleHisPheValThrLysCysAlaPheGIn ProPro ProSerCysLeuArgPheValGinThrAsnlleSerArgLeuLeuGlnGluThrSerGiuGlnLeuVai ；UaLeLiArgP::〇TrpI：LeThrArgGlnAsnPheSe::A:rgCysLeuGluL‘uGlnCysGlnProAspSerSerThr 65 PheAlaValLys I LeArgG丄

TyrVaiGluGiyGlyGlyGlySerProGIvGluProSerGiyProILeSerThrIleAsnProSerProProSer £J：/sGLuSerHisLysSerProAsnMet:；UaAsnCysSerIl·“Met:Il·eAspGluneIleHisHisLeuL·ys；\I：g ProProAsnProLeuLeuAspProAsnAsnLeuAsnSerGiuAspMetAspIleLeuMetGluArgAsnLeuArg ThrProAsnLeuLeuAlaPheVaiArgAiaValLysHioLeuGiuAsnAlaSerGlyIleGiuAlalieLeuArg

70 AsnLeuiinProCyskuProSy.AidThrAlaA 丄 aProSerArg.4isPr*〇nMierieLysAiaGiyAspTYp GinGiu?heArgGluL-/3LeuThr?heTvrLeuVaiThrLeuGiuGlnAidGlnGlL：GlnGln SEQ ID MO：C 3 I oMCM 3 S 7 0 3.ceo 75 … O:\92\92747.DOC -244- 200413407

AlaAspGluGluLeuCysGiyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrVal ProProProSerCysLeuArgPheValGlnThrAsnlleSerArgLeuLeuGlnGiuThrSerGiuGlnLeuVal . AlaLe\iLys?roTrpIieThrArgGinAsnPheSerArgCy〇LeuGluLeuGinCvsGln?roAspSerSerThr ) LeuGlyGlyGlySerGlv/GiyGlySerGlyGlyGlySerGlyGlyGlyThrGlnAspCysSerPheGlnHisSer ProlieSerSerAspPheAldValLys IieArgGluLeuSerAspTyrLeuLeuGirLAspTyr?:roValThr'/al AlaSerAsnLeuGlnTyrValGiuGlyGlyGlyGlySerProGlyGluProSerGlyProlieSerThrIleAsn PrroSerProPiTQSeirLysGluSeirHisLysSerPr'oAsrLMetAlaAsnCysSezrlleiMetlleAspGluIlelle KisKisLeuLysArgProProAsnProLeuLeuAspPrQAsnAsnLeuAsnSerGIuAspHetAspIIeLeuMet: K) GluArgAsnLeuArgThrProAsnLeuLeuAiaPheValArgAlaValLysHisLeuGlur'snA 丄 kserGl'/:le GluAlalleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSerArgHisProXIelielie LysAlaGiyAspTrpGlnGiuPheAraGiuLysLeuTiirPheTvrLeuVaiThrLeuGluGlnAlaGlnGluGln Gin SEQ ID MO：582 15 OMON35709.pep ：0 25 30 35 40 45

AlaAspGluGiuLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlxiArgTrpMecGluArgLeuL'/sThrVal Al aG 1yS e r LysMe 亡G1 :iG1yLeuLeuG1uArgVa1As nT hrGlulieHisP heVaIThrLys Cys a PheG i n ProProProSerCv^sLeuArgPheValGlnThrAsnlleSerArgLeuLeuGInGluThrSerGluGlnLeuVal AlaLeuLysProTrpIleThfArgGlnAsnPheSerArgCysLeuGluLeuGinCysGlnProAspSerSerThr LeuGlyGlyGiySerGiyGlyGlySerGlyGiyGiySerGiyGiyGlySerGlyGIyGlySerGlyThrGlr^.sp CysSerPheGir.HisSerProIIeSerSerAspPheAlaValLysIleArgGiuLeuSerAspTyrLeuLeuGln AspTv rProValThrValAlaSerAsaLeuGlr.TyrValGiuGlvGlyGlyGlySerProGlyGluProSerGly Pro I leSerThrl ieAsnProSerProProSeirLysGluSerHisIjysSeirPiroAsnMetAlaAsnCysSerl MetllsAspGluIleileHisHisLeuLysArgProProAsnProLeuIjeuAspProAsnAsnLeuAsnSerGlu ^spMetiAspneLeuMecGluArgAsnLiuArgThrProAsnLeuLeuAiaPh^ValArgAlaValLysHisLeu GluAsnAiaSerGiylieGluAlalleLeuArgAsnLeuGinProCysLeuProSerAlaThrALaAlaProSer ArgHis ProllellelieLysAlaGLyAspTrpGinGluPheArgGluLysLeuThrPheTyrLeuValThrLeu GluGinAlaGixiGluGinGin SEQ ID MO :633 PMOM35710.pep AlaAspGiuGluLeuCysGlyGiyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrVal AlaGlySerLr/sWetGlnGlyLeuLeuGluArgV-alAsnThrGluIleHis PheVaiThrLysCysAiaPheGln ProProProSerCysLeuArgLeuValGlnThrAsnlleSerArgLeuLeuGlriGiuThrSerGluGlnLeuVal AlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThr LeuGiyGlyGiySerGiyGlyGiySerGlyGlyGIySerGlyGlyGlyThrGlrL^spCysSerPheGlnHisSer ProlleSerSerAsp?heAla^/alLysIleArgGiuLeuSerAspTyrLeuLeuGlnAspTVrProValThr'Mi I IeSerThr UeAsn P’roSerPrcProSerLysGluSerHisLysSeirPrcAsnMetiAlaAsnCysSerlleMecIieAspGluIlel：]^ HisHisLeiiLysArgProProAsnProLeuLeuAspPr GluArgAsnLeuArgThrProAsHLeuLeuAlaPheValArgAlaValLysHisLeuGluAsnAiaSerGlylie GluAiaIleLeuArgAsnLeuGlnProCysLeu?roSerAiaThrA：LaAiaProSerArgH:Ls?r〇IleIle:：L«2 Ι//5ΑΐΑ〇1'/Α3；ρΤ；ΓρΟ1ηΟ1ΐ·ΐΡΐΐ0ΑΓ9〇ΐ·ΐα1<;/2：ΙιδΐιΤ]ηΓΡίΊθΓΓ，/Γΐ«0'ανβ1ΤΪΊ：Γΐ^0ΐι〇]·^ιΟ1ηΛΐβΟ1η〇1ι:〇1η Gin SEQ ID NO：634 "* PMON35711.pep

50 55 60 65 70 75

AlaAspGiuGiuLeuCysGIyGIyLeviTrpArgLeuValLeuAiaGlrL^rgTrp^etGIyArgLeuLysThrVai AlaGlySerL/sMe 匕 GinGC/LeuLeuGV丄ArgVaiAsn丁hrGluIieHisPhe'/alThrLysCysPaaPheGLn ProProProSerCysLeuArgPheValGlnThrAsalleSerArgLeuLeuGir.GiuThrSerGIuGlnLeuVal WaLeuLysProTrpI Le-ThrArgGlpJ.sn?heSerArgCysLeuGl_uLeuGlnCysGln?roAspSei:Se：rThr LeuGIyGlyGlySerGLyGlyGlySerGlyGiyGlySerGlyGlyGlyS8rGlyGlyGiySerGlyThrGlnA：sp CysSerPheGlnHisSerProrieSerSerAspPhsAlaValLysIieArgGIuLeuSerAspTyrLeuLeuGln AspTyrPrcValThrValAlaSerAsnLeuGinTyrVaiGiuGlyGiyGlyGlySerProGiyGluPrcSerGLy ProlieSerThrXleAsHProSerProProSerLysGiuSerHisLysSerProAsr^MetAlaAsnCysSerlie Metl ieAspGLuI ΐΘΐ；1·8Ηί3Ηί3ΐ^6\·ΐΙ/_/5ΑΓ3?Ί：〇？Γ〇Α2ηΡΓ·〇Ι^θΐ·ΐΙ^βΐΛΑ5ρΡΓ〇Α：3ηΑ3ηΙ^θΐ:Α3η5θ：:〇1ιι AspMetAspIleLeuMecGiuArgAsnL^uAr.gThrProAsnl^euLeuAlaPhe'/aiArgAla'/dHysKisLeu GluAsrLnlaSerGlylieGluAialleLeuArgAsnLeuGinProCysLeuPrcSerAlaThrAlaAIaProSer ArgHisProIIerielieLysAiaGlyAspTrpGinGluPheArgGluLysLeuThrPheTyrLeuValThrLeu GluGIr^iaGinGluGlnGin SEQ ID MO :635 S pMCN3 5 7 19. pep MetAlaAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuVal [θΐιΑΐ6ΐ^Γ‘Αι·3Τ1Γ·ρΜθΐ：〇]_αΑΓ9ΐ〇θΐιΙ;/3ΤΐΊΓν3]_Αΐαι31：/3ί2 2：1/：/5Μθΐ:(：ϊ1η0ΐ'/Ι^βιιΙθϋ01ιιΑ:：9,·Λ^ΐΓ'、·5η ThrGluIieHisPheValThrLysCysAlaPheGLnProProProSerCysLeuArgPheValGlnThrAsnlle SerArgLeuLeuGlnGluThrSerGiuGlnLeuVdlAiaLeuLysProTrpIleThrArgGlnAsnPheSerAr? C y s L te > ^ (3 L u L e u G1 n C y s G i n ? r c A 3 p S e r S e r T h r L e u G i 7 GI y G i y S e r G1 y G17 G1 y S e r G i y G1 v G1 y 3 e r G1 yG i yC ^ y^T h r G1 Π.Λ 3 p C y 3 b e r P h e G1 η H i 5 2 e r P r ο 11 e S e r S e r A s p ? h e Λ1 ar / a i L / 5 I i e A r g GI u L e u SerAspTy r LeuLeuG l p.TyrVaiG I uGlyGiyGiyGlySer ProGlyGluProSerGly Pro I IeSerThr I AsnProSerProProSerLysGluSerHisLyoSerProAsnMetAlaAsnCysSerIleMetlleAspGluIle Γ leHisH LsLeuLysArgProProAsnProLeuLeuAspProAsnAsnLeuAsnSerGluAspMetiAspIleLeu MetGiuArqAsnLeuArgThrProAsnLeuLeuAlaPheValArgAlaVaiLysHisLeuGluAsnAlaSerGiy IleGLuAialleLeuArgAsnLeuGinProCysLeuProSerAiaThrAlaAiaProSerArgHisProIlelie

O:\92\92747.DOC -245 - 200413407 lieLysAlaCIyAspTrpGLnGluPheArgGIuLysLeuThrPheTyrLeuvalThrLeuGluGlr^laGlr.Glu GlnGln SEQ ID MO：686 〇MCN3 5'7 2 0 .cep 5 、

AlaAlaSerAsnLeuGlnAspGluGluLeuCysGlyGiyLeuTrpArgLeuvalLeuAIaGlnArgTrpMetGlu ArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGiuArgValAsnThrGluIieHisPheValThr LysCysAlaPheGinProProPr'oSerrCysLeuArgPheValGlr/ThrAsnlleSerArgLeiiLeuGinGluThr SerGluGlnLeuVaiAlaLeuLys ProTrpIleThrArgGinAsnPheSerArgCysLeuGluLeuGlnCysGln 10 ProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGiyGlySerGIyGlyGiyThrGirL^spCys Ser PheGlnHisSerPro IleSerSerAspPheAlaVaILysIleArgGluLeuSerAsDTyrLeuLeuGirLnSp Tyr?roValThrVaiTyrValGluGlyGlyGlyGlySerProGlyGluProSerGiy?roIieSerThrIieA〇a tAlaAsnCysSer I leMet I leAspGiuliel le _ HisHisLeuLysArgProProAsnProLeuLeuAspProAsnAsnLeuAsnSerGluAspMetAspIIeLeuMet 15 GiuArgAsnLeuArgThrProAsnLeuLeuAlaPheValArgAiaValLysHisLeuGluAsnAlaSerGlylie GiuAlaIleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaPvlaProSerArgHis?r〇Il<eIleI： _le Ly s A1 aG 1 y As pT r pG 1 nG 1 u ?he Ar gG 1 uL '/s L e uT h r ?h eTy r L eu Va 1T h r L e uG 1 uG 1 nA 1 aG I* r‘G i uG i n Gin SEQ ID MO :587 ‘ 20 pMOM3 57 21. pep

AlaValAlaGlySerLysMetGlPxGlyLeuLeuGiuArgValAsnThrGiuIIeHisPheValThrLysCysALa PheGlnProProProSerCysLeuArgPheValGlnThrAsnlleSerArgLeuLeuGlnGiuT'hrSerGiuGlii _ LeuValAlaLeuLys?roTrpIleThrArgGlnAsn?heSerArgCysLeuGluLeuGlnCysGln?roAspSer 25 SerThrLeuGlyGlyGiySerGlyGlyGlySerGlyGiyGlySerGlyGlyGlyThrGlnAspCysSerPheGln HisSerProIleSerSerAsp?heAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProVai ThrVaiAlaSerAsnLeuGlnAspGluGluLeuCysGlyGiyLeuTrpArgLeixValLeuAlaGlnArgTrpMet GluArgLeuLysThrTyrValGluGlyGlyGl'/GlySerProGiyGluProSerGlyProIleSerThrlleAsn i PrQSerProProSerLysGluSerHisLysSerProPvsnHetAiaAsnCysSerlleMetlleAspGluIlelis )〇 HisHisLeuLysArgProProAsnProLeuLeuAspProAsnAsnLeuAsnSerGIuAspMetAspIleLeuMer. GluArgAsnLeuArgThrProAsnLeuLe'^AlaPheValArgAlaValLysHisLeuGiuAsnAlaSerGIylie

LysAlaGlyAspTrpGlnGluPheArgGluLysLeuThrPheTyrLeuValThrLeuGiuGloAiaGinGiuGln Gin SEQ ID NO :63 8 35 PMON35722.pep Λ1a S e rLy s Me CG1nG1yLeu LeuG1uAr gValAs nT h rG i u11e H i s ? h eVaIThr Ly3 Cy〇 AIa ? h eGIn ? r o ProProSerCysLeuArgPhe'/alGLnThrAsnlleSerArgLeuLeuGinGluThrSerGiuGlnLeuValAla 40 LeuLysProT'rpI le.ThrArgGlnAsnPheSer ArgCysLeuGiuLeuGinCysGlnProAspSerSerThrLeu

GlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGiyGlyGiyThrGlnAspCysSerPheGlnHisSerPrj IleSeirSerAspPheAlaValLys Ιΐ0Αι：3〇1υ1_ι0ΐι5·2ΓΑ3ρΤγ2：[αθΐιΙ_1·0ΐιΰ]·ηΑ5ρΤ'ν,2：?：!：〇νΑΐΤΐ^Γν·ΕΐΛΐ3 Ser Asr.LeuG InAspG luG iuLeuCy sG lyG ly LeuTrp Ar gLeuVai LeuAiaG IrJ^rgTrpMe CG luAr gLeu 一 LysThrValAlaGlyTyrValGluGiyGlyGlyGIySerPrcGiyGluPrcSerGlyPrcIleSerThrlieAsn 45 ProSerProProSerLysGluSerHisLysSerProAsri-letAiaAsnCysSer II-2MetIieAspGluIieIIe HisHisLeuLysArgProProAsnProLeuLeuAspProAsnAsnLeuAsnSerGluAspMetAspIleLeuMec GluArgAsnLeuArgThrProAsnLeuLeuAlaPheValArgAiaVaiLysHisijeuGLuAsrLAlaSerGlyl l_e GluAlal leLeuArgAsnLeuGlnProCysLeuPrcSerAlaT’ndaAiaProSerArgHis?ro二ellelie Ly s AI aG 1 y Λs pTr pG I nG I u P he Ar gG i u Ly s LeuT h r ?heT v r Le uVa 1T h r L e uG 1 uG I nA i aG 1 nG 1 uG 1 n 50 Gin SEQ ID NO:639 PMCM35723.pep

_ AlaProProSerCysLeuArgPheValGinThrAsnlleSerArgLeuLeuGinGluThrSerGluGinLeuVaL 55 AldLeuLysProTrpI leThrArgGlpJVsnPheSerArgCy^LeuGiuLeuGlr.CysGlnProAspSerSerThr

LeuGiyGiyGlySerGLyGiyGiySerGlyGlyGiySeroiyGlyGiyThrGinAspCysSerPheGLnHisSrir ?roI leSerSerAspPheAlaValLys I leArgGluLeuSerAspTyrLeuLeuGlnAspTyr ?ro’'/aiThr、’a· l AiaSerAsnLeuGin.AspGluGIuLeuCysGly^ly^^^TrpArgLeuVaiLeuAlaG In^.rgTrpMecG LuArg LeuLysThrValAlaGlySerLysMetGInGIyLeuLeuGluArgVaiAsnThrGluIleKisPheVaiThrLys 60 C ys A1a ?heG i η P r oTyrVa1G1uGIyG1yG1yGIyS er P r oG1yG1u ? ro S erG1y p ro1i e S e rThr11eAs n

ProSerProProSeirLysGiuSerHisLysSerPiroAsnMe tAlaAsnCysSerl LeMeCl leAspGiullelie HisHisLeuLysAirgProProAsnPrGLeuLeuAspProAsnAsnLeuA^nSerGluAspMetAspIieLeuMe?: G1 u A r g A s n L e uA r gT h r ? r c Λ s n L e u L e u AI a ? h e Va IA r g A i a Va 1 Ly s K i s L e uG 1 u A s I a S e r G i y XI *2 GluAla工leLeuArgAsr丄 euGlnProCysLeuProSerAlaThrAlaAlaProSerArgH isProIielielle 65 L ys A1 aG 1 y As pT r pG 1 nG 1 u ? h e Ar gG i uL y s L e uT h r ? h eT y r L e u Va 1T h r L e uG I uG I nA i aG I nG 1 uG I n

Gin SEQ ID NO : 690 pMON3 57 2 5. pep 70 AlaThrAGn I ieSerArgLeuLeuC Ip.C LuThrSerG luG lr.LeuVa iAiaLeuLys ?roTrp I ieThrArqGlri A s n ? h e S e r A r g C y 3 L e u G i u L e u G1 n C y s G L n ? r o A s p S e r S e :r T h:: L e u G L·/ G 丄 7 G1· y S e r G1 y G i y G1 y ΰ e i: GLyG LyG Iz/SerGlyGLyG Lv'rhrGinAspCysSerPheGlnHisSerProIleSerSerAspPheAia'/alL./s ILeArqGluLeuSerAspTyrLeuLeuGLaAspTyrProVaiThrVaLAlaSerAsnLeuGl.aAspGluGluLeu CysO LyGiyLeuTrpArgLeuValLeuAlaGlnArqTrpMecGluArgLeuLvsThrValAlaGlySerLy〇Mec 75 Gir.G LyLeuLeuGiuAr-gVaLAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCys -246-

O:\92\92747.DOC 200413407

Leu Arg PheVa iG In’TyrVa 1G luG丄 yG LyG LyG LySer ProG LyG lu PrroSerrGiyPro I leSerThr 11 e As η

XieAspGluIlelle

HisHisLeuLysArgPro ProAs4nProLeuLeuAspProAsnAsnLeuAsn5erGluAspMet:Asp I leLeuMet GluArgAsnLeuArgThrProAsnLeuLeuAiaPheVaJLArgAiaValLysHisLeuGluAsnAlaSerGlyrie 5 GluAlalleLeuArgAsnLeuGLaProCysLeuProSerAlaThrAlaAlaProSerArgHisProIlellelle Ι^ν^Αΐ301，；/Α5ρΊ'::ρ〇1ηΟ1ιαΡΗθΑι·9〇1υιΙ//3ΐ4θΐαΤ1ιι:Ε>’ηθΤ7ΓίιβυνΑΐΤΚ2：Ια€ΐα(31，α(31ηΑΐ^Ο1η0ΐιι0·Ιη Gin SEQ ID MO :691 ^ PMOM35726.ceD 10 …

AlaArqjPheV’aiGinThrAsnlleSerArgLeuL^uGlnGluThrSerGluGlnLeuVUAlaLeuLysPrQTrp I leThrArgGiiiAsnPheSerArgCysLeuGiuLeuGinCysGlnProAspSerSerThrLeuGlyGIyGlySer GlyGlyGlySerGlyGlyGlySerGiyGIyGlyThrGlnAspCysS'arPheGlnHisSerProIleSerSerAsp PheAlaValLysI ieArgGiaLeuSerAspTyrLeuLeuGinAspTyrProValThrValAiaSerAsnLeuGi-n 15 AspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAla GlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheVaiThrLysCysAlaPheGlnPro Ρ：Γ〇5β2：Ρ::οΡ2：ο5<2ΐ·Ι；·/5〇1ι:2θ：:Ηΐ3ί·Γ；/ί3 5θΐ:Ρ：Γ〇Α.5ηΜ0ί：ΑΐβΑ5η€'/35θ2Γΐ leMe t IleAspGiuI lei ie HisHisLeuLysArgPrcProAsnProLeuLeuAspProAsnAsnLeuAsnSerGiuAspMetAspIleLeuMet 20 GluArgAsnLeuArgThrProAsnLeuLeuAlaPheValArgAlaValLysHisLeuGluAsnAIaSerGlylle GluAiaIleLeuArgAsnL<ei:Gln?roCysLeuProSerAlaThrAlaAla?roSerArgHis?roIleI lei ie LysAlaGlyAspTrpGinGluPheArgGluLysLeuThrPheTyrLeuValThrLeuGiuGlnAlaGlnGIuGin Gin SEQ ID MO :592 25 pMON35744.pep

AlaSerAsnLeuGlr^spGiuGl'JLLeuCysGiyGiyLeuTrpArgLeuValLeuAlaGinP.rgTrpMetGiuArg LeuLysThrVaiAiaGlySerLysMetGlnGlyLeuLeuGiuArgValAsnThrGIuIleHiaPheValThrLys CysAlaPheGlnProProProSerCysLeuArgPheValGlrVThrAsnlleSerArgLeuLeuGlnGluThrSer 30 GluGlnLeuVaiAiaLeuLys ProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnPro

AspSerSerThrLeuGlyGlyGiySerGlyGiyGiySerGlyGlyGlySerGiyGlyGlySeirGlyGlyGlySer GlyThrGlnAspCysSezrPheGlnHisSeirPiroIleSeirSerAspPheAlaValLys IleArgGluLeuSerAsp TyrLeuLeuGlnAspTyrProValThrValAlaTyrValGluGiyGlyGlyGlySerProGlyGIuProSerGiy ProlieSerThrIieAsnProSerProProSerLysGiuSerHisLysSerProAsnMetAlaAsnCysSerlie 35 Me 111eAs pG1uIi e11e H i s H i s L euLys Arg Pr ο P r oAs n ? r oLeuL euAsp ? ro As nAs nL euAs n S e r〇1u

AspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeuAiaPheValArgAlaValLysHisLeu GluAsnAlaSerGlylleGluAlalisLeuArgAsnLeuGlnProCysLeuPrcSerAlaThrAlaAlaProSer ArgHisProliellelleLysAlaGlyAspTrpGlriGluPheArgGluLysLeuThrPheTyrLeuValThrLeu GluGlnAlaGlnGluGinGlxn SEQ ID NO :693 40 ρΜ0Ν3 57 45. pep

AlaAsnLeuGlnAspGiuGlLiLeuCysGlyGlyLeuTrpArgLeuVaiLeuAiaGlnArgTrpMetiGluArgLeu 45 AiaPheGlnProProProSerCysLeuArgPheValGlnThrAsnlleSerArgLeuLeuGlnGluThrSerGlu GinLeuValAlaLeuLysPro.TrpIleThrArgGlnAsnPheSerArgCysLeuGiuLeuGlnCysGlnProAsp S e r S e r T h r L e uG 1 yG I yG 1 y S e r G1 yG 1 yG 1 y S e rG I y G1 yG 1 y S e r G1 yG 1 y G1 y S e r G1 yG 1 yG 1 y S e r G1 y •ThrGJLrLAspCysSerPheGlnHisSerProIleSerSerAspPheAiaVaiLysIleArgGluLeuSerAspTy：： LeuLeuGinAspTyr?roValThrVal\ia5erTyrVaiGluGlyGiyGlyGiy5er?rcGiyGiu?roSerGiy 50 ?::〇 lieSer.Thr I LeAsnProSerProPrroSerLysGiuSerHisLysSeirPrOAsnMetAlaAsnCysSerii·^;

Me tl LeAspGLul lei leHisHisLeuLysArgProProAsnPrcLeuLeuAspProAsnAsnLeuAsnSerGi'j AspMe 二\sp 1

GluAsnAiaSerGi:/I LeG luAial LeLeuArgAsriLeuGiriProCysLeviProSerAiaTh.rAlaAlaProSer A r g K i s ? r ο I i e I i e 二 1 e L y s A1 a G1 y A s p 丁 r p G1 r‘ G1 u ? h e A r g G1 u L·/ s L e u T h r P h e T y r L e u V a 1T h r ^ 55 GluGinAlaGinGluGlnGin SEQ ID NO :694 pM0M3 57 4 δ . cep

AlaLeuG ir.AspGiuGluLeuCysGIyGlyLeuTrpArgLeuvdlLeuAlaGlr.ArgLeuKetGluArgLeuL.ys 60 ThrVa LAlaGi./SerLysMecGinGiyLeuLeuGiuArgValAsnThrGluIleHisPhe'/aiThrljysCysPda

PheGin?ro?ro?roSerCysLeuArgPheValGInThrAsnI ieSerArgLeuLeuGInGluThrSerGluGIp. LeuValAlaLeuLys ProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGInCysGinProAspSer S e r T h r L e uG 1 yG i yG I y S e rG1 yG i yGI y S e rG1 yG1 yG1 y S e r G1 yG1 yG1 y S e rG1 yG i yG1 y S e rG1 yT h r GlnAspCysSerPheGlnHisSerPiroIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeu 65 LeuGlnAspTyrProVaiThrValAiaSerAsnTyrValGluGiyGiyGlyGlySerProGlyGluProSerGiy ?ro工 leSerThrl ieAsnProSeirPiroPrGSerLi/sGiuSerHisLysSer PrcAsnMetAlaAsnC'/sSer I Me 111 eAs pG 1 u 11 e 11 e H i s l·： i s L e u L y s A r g P r ο ? r o As n ? r o L eu L e uAs p ? r o As nAs nL eu As n S 0 r G1 u As pMe cAs p 11 e Le uMe tG i u Arg As nLeuArgTh r ? rroAs n LeuLeuA JL a PheV’a i Arg Ai aVa 1 Lys H i s Le、二

GliaAsnALiiSerGLyl LeGluALaUeLeuArgAsrieuGinPr^CysLeuPlTCSerAlaThrAlaAlaProSer 70 .ArqiHis?i-〇：； iel iel： LeLysAiaGlyAspTrpGirvGiuPheArgGLuLysLeuThrPheT'yrLeuVaLThirL士u

GluGlnAiaGlnGiuGinGla SEQ ID NO：β95 〇M0M3 5 7-； 7 . pep .

O:\92\92747.DOC -247- 200413407

ValAlaGl’/Seri^/sMeCGinGiyLeuLeuGiiaAr&ValAsnThrGiuIieHisPheValT'jirLysCysAiaPhe

Gln?ro?ro?roSerCysLeuArgPheValGlnThrAsnIleSerArgLeuLeuGln.G LuThrSerGiuGlaLeu

ValAiaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSer 5 ThrLeuGlyG；yGIySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyThrGln AspCysSerPheGlaHisSerProIIeSerSerAspPheAlaValLysIleArgGiuLeuSerAspTyrLeuLeu GinAspTyrProValThrValAiaSerAsr.LeuTyrValGluGlyGIyGlyGlySerProGlyGluProSerGly ProIieSer.ThrlleAsnProSerProProSerL'/sGluSeirHisLysSerProAsnMetAlaAsnCysSerrie MetIleAspGluIlelleHisHisLeuLysArgProProAsnProLeuLeuAspProAsnAsnLeuAsnSerGlu 10 AspMetAGpIieLeuMetGluArgAsnLeuArgThrProAsnLeuLeuAiaPheValArgAlaValLvsHisLeu GluAsnAlaSerGlyl leGluAlal leLeuArgAsriLeuGlnProC'/sLeuPiroSeirAlaThrAlaAlaProSer ArgKis?r〇rieIIeIleLysAlaGiyAspTrpGlnGlu?heArgGluLysLeuThr?heTyrLeuValThrLeu GluGloAlaGinGiuGlnGln SEQ ID NO :696 1 5 pMON3 57 43. pep

AiaGIuGluLeuCysGlyGlyLeuTrpArgLeuVaiLeuAiaGlnArgTrpMetGluArgLeuLysThrVaiAla GlySerLysMetiGinGiyLeiiLeuGluArgValAsrVrhrGiuIleHisPhe-'/aiThrLysCysAiaPheGlnPro ProProSerCysLeuArgPheVaiGIriThrAsnlieSerArgLeuLeuGinGIuThrSerGluGInLeuVaiAia G1 yG 1 yG 1 y S e r G1 y G1 vG 1 y S e rG 1 yG I yG I y S e r G1 y G1 y G1 y S e r GI y G i y G1 y 5 e r G1 y T h r G i nA 3 p (： y s SerPheGlnHisSerProIieSerSerAspPheAlaValLysIieArgGluLeuSerAspTyrLeuLeuGlrL^sp Ty r P r o Va lThr Va 1 Ai a S e r As nL euG 1 nAs pTy r Va 1G1 uG 1 yG i yG i yC* i y S e r P r oG I yG I u ? r o S e r G1 y 身 ProIleSerThrl JLeAsnPiroSerPiroPirQSeirLysGiuSerHisIjysSeirPrQAsrLHetAlaAsnCysSerl 1¾ 25 MetllsAspGliillelleHisHisLeuLysArgPrQPrOAsnProLeuLeuAspPzroAsnAsnLeiiAsnSerGiii AspMetAspIleLeuMetGluArgAsnLeuArgThrProAsnLeuLeuAlaPheValArgAlaVaiLysHisLeu GluAsnAlaSerGlyIleGluAlaIieLeuArgAsp.LeuGin?roCy3LeuProSerAlaThrAla..nIa?rcSer ArgHisProIlelielieLysAlaGiyAspTrpGlr.GiuPheArgGluLysLauThrPheTyrLeuVaiThrLeu GluGl^IaGlnGiuGinGin SEQ ID ΜΟ:β97 30 PMON35749.pep

AlaLeuC'/sGlyGi:，LJeuTrpArgLeuValLeuAiaGlnArgTrpMet:GluA;rgLeuI/:/sThr\/alAlaGlySer LysMetGlnGiyLeuLeuGluArgValAsnThrGluIieHisPheValThrLysCysAlaPheGinProP::^)?::：) 35 SerCy3L<auArg?heValGlnThrAsnI leSerArgLeuLeuGlnGluThrSerGiuGlnLeuVamaLeuLys PrroTrpIle，ThrArgGlnAsnPheS«2rArgCysLeuGluLeuGlnCysGln?roAspSerSerThrLeiiGl'/Gly G1 y3erGIyGIyG1 y Se rG1 yG 1 yG 1 y Se rG .1 yG iyG 1 y SerG 1 yG 1 yG 1 y SerG I vThrGInAspCy s Ser Phe GlnHisSer ?roIleSerSerAspPheAiaValLyslieArgGluLeuSerAspTyrLeuLeuGinAspTyrPro ValThrValAlaSerAsnLeuGIrL^spGluGluTyrVaiGluGlyGlyGlyGiySerProGiyGluProSerGly 40 ProIleSerThr HeAsn?roSer?roPro3erLysGluSerHisLysSer?roAsrLHecAlaAsnCysSer lie

MetlleAspGiuIlelleHisHisLeuLysArgProProAsnProLeuLeiiAspProAsnAsnLeuAsnSerGiu AspMetAspIieLeuMetGiuArgAsnLeuArgThrProAsnLeuLeuAlaPheValArgAlaValLysHisLeu G1 uAs nA i aS e rG ly I i eG 1 uA 1 a 11 eLeuAr g AsnLeuG in? r oCy s Leu ? r o S er A iaThr AI a P ro S -3 r 4) GiuGlnAIaGlnGiuGlnGln SEQ ID NO :693 pMOM35750.pep

AlaLeuCysGlyGlyLeuTrpArgLeuVaiLeuAiaLGiRArgTrpMstGiuArgLeuLysThrVaiAlaGiySer

LysMetGInGiyLeuLeuGiuArgVaiAsp.ThrGluIIeHisPheVaiThrLysCvsAiaPheGinProProPro

SerCysLeuArgPheValGlnThrAsnlleSerArgLeuLeuGinGluThrSerGluGlnLeuvalAlaLeuLys

ProTrpIieThrArgGlnAsnPheSsrArgCysLeuGluLeLiGlnCysGinProAsOSarSerThrLeuGlyGiy

GlySerGiyGlyGlySerGiyGlyGlySerGlyGlyGLySerGiyGlyGlySerGlvThrGlr^spCysSerPhe

GlnHisSerProIieSerSerAspPheAlaValLysIleArgGluLeuSerAsOTvrLeuLeuGlnAsoTyrPro

ValThrVaiAlaSerAsnLeuGlnAspGi-aGLuTyrValGiuGlyGLyGIyGlySerPioGlvGiuProSerGi·/

FroiUSerrT^irlLeAsnProSerProPrcSerLi/sGluSerHisLysSe^Pr^AsnMecAlkAsnCysSerl.U

AspMer.AspIieLeuMetGluArgAsnLeuArgThr?rcAsnLeuLeuAla?hevalArgAla'/alLy5HisLeu GluAsaAlaSerGIyX LeGluAlalieLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaProSer ArgHisPro：iellelleLysAIaGiyAspTrpGlnGluPheArgGiuLvsLeuThrPheTvrLeuValThrLeu GluGinAiaGlnGiuGlnGin SEQ ID MO： 699 * PMON35769.pep '

AiaLeuCysGLyGlyLeuTrpArgLeuMlLeuAlaGlnArgTrpMecGl^ArgLeuLvsThrValAlaGiySej：

LysMetGir.GiyLeuLeuGiuArgVaiA3aThrGluIieHis?heValThrLysCysAia?heGln?roPro?ro

SerCysLeuArgPheVaiGlnThrAsnlleSerArgLeuLeuGlnGluThrSerGiuGInLeuValAlaLeuLys oTrp ^ -9 ： ^PheSerArgCysLeuG luLeuGInCvsArgProAspSerS^rThrLeuG 1 '/G Ly

GiySerGiyGlyGlySerGlyGIyGlySerGiyGlyGiySerGlvGivGivSerGlvThrGinAsaCvsSerPhe GinhisSerProIIeSerSerAscPheAldValLysIieArgGluLeuSerAsOTvrLeuLeuGinAspTyrPro ^AxdSeΓA3nLeuGlΓu\spGL^Gl·αTyr7alGiuGlyGivGLvGLvSerProGiyGlu?roSeΓGLy ProtieJerThrlUAsnProSerProProSerLysGluSerHisLysSerProAsruMetAlaAsnCysSerrie Metl ieAspGiuIiel leHisl-iisLeuLysArqProProAsnPr-cLeuLeuAsoProAsnAsnLeuAsaSerGlu AopMecAsp：LeLeuMecGluArgAsnLeuArgThrProAsr.LeuLeuAiaPheVaiArgAiavdlLysHisLeu ^.uAsnAlaSerGlylieGiuAIalieLeuArqAsnLeuGIr.ProCysLeuProSerAlaThrAlaAlaProS^c -248-

O:\92\92747.DOC 200413407

ArgHis Pro IleileileLvsAlaGiyAspTrpGInGiuPheArgGluLyoLeuThrPheTyrLeuVaIThrLeu GluGlirAiaGlnGluGlnGln SEQ ID N0:7〇〇 pM〇N3 5771. pep AlaSerLysMetGinGlyLeuLeuGluArgVaiAsnThrGluIleHisPhe'/aLThrL/y.sCysAlaPheGlnPro LeuLysProTrpIleThrArgGiaAsnPheSerArgCysLeuGluLeuGlnCysGinProAspSerSerThrLeu GlyGlyGlySerGiyGlyGlySerGlyGlyGlySerGiyGlyGiyThrGInAspCysSerPheGinHisSerPro 10 I leSerSerAspPheAiavaiLys IleArgGiuLeuSerAspTyrL-auLeuGlriAspTyr ProValThrValAia SerAsnLeuGlnAspGluGluLeuCysGlyGlyLsuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeu LysThr'/alAlaGiyTyrValGluGiyGlyGlyGiySerProGlyGluProSerGlyProIIeSerThrlieAsn HisHisLeuLysArgProProAsnProLeuLeuAspProAsaAsnLeuAsnSerGluAspMetAspIleLeuMet: 15 GluArgAsnLeuArgThrProAsnLeuLeuAlaPheValArgAlaValLysHisLeuGIuAsrL^laSerGlyIle GluAlalleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAiaProSerArgHis ProllelleIle LysAiaGlyAspTrpGlnGluPheArgGluLysLeuThrPheTyrLeuValThrLeuGiuGlr^laGlnGluGla Gin SEQ ID NO：701 - 20 pMON35774.pep AlaGlnAspAspGluLeuCysGlyGiyL.euTrpArgLeuVaiLeuPvlaGlnArgTrpMecGluArgLeuLvsThr ValAlaGlySejrLysMetGinGlyLeuLeuGluArgValAsnThirGiuIieHisPheVaiThirL^/sCysAlaPhe GlnProProProSerCysLeuArgPheValGlnThrAsx^IleSerArgLeuLeuGlnGiuThrSerGluGlnLeu ThrLeuG 1 yG 1 yG 1 yS erG 1 yG 1 yG 1 '/S erG 1 yG 1 yG 1 yS erGi yG 1 yG 1 yS erG i yG 1 yG 1 ySerG i yG 1 yG i y ArgGluLeuSerAspTyrLauLeuGinAspTyrProValThrVaiAiaSerAsnLeuTyrValGluGiyGlyGiy Giy3er?roGlyGIuProSerGiyProIleSerThrIleAsnProSerPrc?roSerLysGlu3erHisLysSer ProAsnMetAlaAsnCysSerlleMetlieAspGluIlelleHisHisLeuLysArgProProAsnProLeuLeu AspProAsnAsnLeuAsnSerGluAspMetAspIieLeuMetGluArgAsnLeuArgThrProAsnLeuLeuAIa PheValArgAlaValLysHisLeuGluAsnAlaSerGlylleGiuAlalieLeuArgAsnLeuGlnProCysLeu ProSerAiaThrAlaAiaProSerArgHisProIlellelieLysAlaGiyAsp'TrpGlnGluPheArgGluLys 乙011<1112：卩11已-丁：/2：乙01^/彐1<1?112：乙已11〇丄11〇111^彐〇1：1〇11_1〇11^3丄11 SEQ ID NO :7 02 PMON35775.pep AlaGlnAspGiuGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThr ValAlaGlySerLysMetGinGlyLeuLeuGluArgvalAsnThrGluIleHisPheVaiThrLysCysAiaPhe ValAlaLeuLysProTirpIleThrArgGlriAsnPheSeirArgCysLeuGlujLeuGlnCysGlnPiroAspSerSer ThrLeu?ro?ro?roTrpSerProArgProLeuGlyAlaThrAla?roThrThrGlrL^spCysSerPheGlnHis Ser?roIIeSerSerAspPheAlaValLysIieArgGIuLeuSerAspTyrLeuLeuGlaAspTyr?roValThr _ Va 1A1 a S e r As nLeuTyrVa iG1 uG 1 yG!yG 1 yG 1 y Ser P roG 1 yG 1 u?SerG 1 y Pr ο 11 eSerThr 工 1 eAs n 45 ProSerProPrroSerLysGluSerHisLysSerProAsaMetAlaAsnCysSerlleMetlieAspGiullene HisHisLeuLysArgProProAsnProLeuLeuAspProAsnAsnLeuAsnSerGluAspMecAspIIeLeuMet: GluArgAsnLeuArgThrProAsnLeuLeuAlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlylie GluAialleLeuArgAsriLeuGlnPrcCysLeuProSerAiaThrAlaAiLaProSerArgHisProIlellelLe LysAlaGlyAspTrpGinGluPheArcSliiLysLeu.ThrPheTyrLeuValThrLeuGiuGlrJUaGlnGluGLri 50 Gin S£Q ID MO :703 ' ?MOM35776.pep 一 AiaGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGLnArgTrpMecGluArgLeuLysThr 55 7alAlaGlySerLysMecGlnGlyLeuLeuGLuArgValAsaThrGiuIieHi3?heValThrLysCy3Ala?he GlnProPrcProSerCysLeuArgPheValGInThrAsnlieSerArgLeuLeuGinGluThrSerGluGlnLeu ValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGinCysGlr.ProAspSerSer ThrLeuProPro?roTrpSer?roArgProLeuGlyAlaThrAla?roThrAiaGlyGlnProProLeuThrGia AspCysSerPhsGLnHisSeirProIl^SerSerAspPheAlaVal-LysIleArgGluLeuSerAspTyrLeuLeu 60 GirLAspTyrProValThrValAlaSerAsnLeuTyrValGluGlyGlyGlyGlySerProGlyGluProSerGl·/ ProIleSerThrIleAsnProSerProProSerLysGluSerHisLysSerProAsnHecAlaAsnCysSerlle MetlleAspGiuIlelieHisHisLeuLysArgProProAsnProLeuLeuAspProAsnAsnLeuAsp.SerGlu AspMetAspIleLeuMetGluArgAsnLeuArgThrProAsaLeuLeuAiaPheValArgAlaValLysHisLeu 65 ArgHisProIlellelieLysAiaGlyAspTrpGlaGluPheArgGluLysLeuThrPheTyrLeuValThrLeu GluGLaAiaGinGliiGlnGin SSQ ‘ID ;i〇：7 04 pMOM3216 9.oep/pM〇N40000. pep 70 AidThrProLeuGiyProAlaSerSerLeuProGinSerPheLeuLeuLysSerLeuGluGlnValArgLyslie L*euGlyHi：3：5erL«euG：Lv'.i； LePrroTrpAiaProLeuSerSerCys ProSerrG LoAlaLeuGlnLeuAidGLy-Cyg LeuSerGlp.LeuHiGSerGlyLeuPheLeuTyrGlnGiyLeuLeuGlriAlaLeuGluGly I leSerProGLuLeu _ GI y P r oT h r L e uA 3 cT h r L euG I n L eu A s p Va i AI a As ρ P h e A i aT h r T h r I L -eT r pG I nG 1 rdie cC 1 uG I u L e u 75 GiyMetAlaProAlaLeuGinProT'hrGlnGiyAlaMetiProAldPheAlaSerAlaPheGiaAr'gArgAiaGiy 25

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O:\92\92747.DOC -249- 200413407 5 10 15 20 25 GLyValLeuVaiAidSerHisLeuGlnSerPheLeuGluValSerTyrArgVaiLeuArgHisLeuAlaGlriPrci TyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProXleSerThr IleAsnProSerProProSer LysGluSerKisLysSerProAsnMetAlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGla ArgTrpMe tGluArgLeuLysThrValAlaGlySerLysMe tGlnGlyLeuLeuGluArgVaiAsnThrGlu He HisPheValThrLysCvsAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnlleSerArgLeu LeuGInGluThrSerGiuGlnLeuVaiAiaLeuLyoProTrpIIeThrArgGlnAsnPheSerArgCysLeuGlu LeuGlnCysGInProAspSerSerThrLeuGlyGlyGiySerGiyGlyGlySGrGlyGlyGiySerGiyGlyGly SerGlyGlyGiySerGlyThrGLnAspCysSerPheGlnHisSerProiieSerSerAspPheAlaVaiLysIle ArgGluLeuSerAspTyrLeuLeuG；LrLAspTyrProValThrT/a：LAla_Se::；\snLJeuG：Lii SEQ ID NO： 70 5 OM0N32133.pep AlaThrProLeuGlyProAiaSerSerLeu?roGiaSer?heLeuLeuLysSerLeuGluGlnValArgLysIle GinGlyAspGlyAlaAiaLeuGInGluLysLeuCysAiaThrTyrLysLeuCysHisProGluGluLeuValLeu LeuGlyHisSerLeuGlylleProTrpAlaProLeuSerSerCysProSerGiaAlaLeuGlnLeuAiaGlyCys GlyProThrLeuAspThrLeuGlnLeuAspValAiaAsp?heAiaThrThr：ieTrpGlriGlni4etGiuGluLeu GlyMetAlaProAiaLeuGlnProThrGlr.GlyAlaMecProAlaPheAiaSerAlaPheGlnArgArgAlaGiy GlyValLeuValAiaSerHisLeuGlnSerPheLeuGiuVaiSerTyrArgValLeuArgKisLeuAlaGlnPro TyrValGluGlyGIyGlyGlySer ProGiyGiuProSerGlyProIleSerThr11eAsnProSerProPrcSer LysGluSerH i s Lys Ser ProAsnMe tAlaAsnLeuG inAspG iuGluLeuCysGIvGlyLeuTrpArgLeuVa i LeuAlaGlnArgTrpMetGiuArgLeuLysThrValAiaGIySerLysMetGlnGIyLeuLeuGluArgValAsn ThrGluIleHisPheValThrLysC'/sAlaPheGinPr'oProProSerCysLeuAirgPheValGinlleAsrilie SerArgLeuLeuGlnGluThrSerGluGlnLeuValiUaLeuLysProTrpIleThrArgGlnAsnPheSerArg CysLeuGluLeuGlnCysGlnProAspSeirSer'ThrLeuGlyGlyGlySerGlyG 丄 yGlySerGlyGl’/Gl'/Ser GlyGlyGlySerGlyGiyGIySerGIyThrGlpJ^scCysSerPheGinHisSerProneSerSerAspPheAla ValLysIIeArgGIuLeuSerAspTyrI；euLauGinAspTyr?roVaiThrVaIAlaSer SEQ ID :705

30 35 40 45 50 55 60 65 70 75 PMON32273.pep AlaThrProLeuGlyProAlaSerSerLeuPrcGInSerPheLeuLeuLysSerLeuGluGlnValArgLyslie GlnGlyAspC小丨 a LeuGlyKisSerLeuGiyIIeProTrpAlaProLeuSerSerCys?roSerGInAlaLeuGlnLeuAl.aGiyCys LeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlriAlaLeuGluGiylleSerProGIuLeu GlyProThrLeuAspThrLeuGInLeuAspValAlaAspPheAiaThrThrlleTrpGinGirLMetiGiuGluLeu GlyMetAlaProAlaLeuG 丄 η?Γ·〇Τΐΐ2：ΟΐΓ^31;/ΑΐαΜ2 = ?：Γ〇Αΐ^?ΙΐθΑΐΑ5βι:ΑΐαΡίΊεΟΙ·ηΑΓ·9Αχ9Αΐ3〇1：/ GlyValLeuVaiAlaSerHisLeuGinSerPheLeuGluVaiSerTyrArgVaiLeuArgHisLeuAlaGlnPro TyrValGluGlyGlyGIyGiySerProGlyGluProSerGlyPrcIleSerThrIleAsaProSerProProSer LysGluSerHisLysSerProAsaMecAIaProProSerCysLeuArgPheValGlnThrAsnlieSerArgLeu LeuGlnGluThrSerGiuGlnLeuValAlaLeuLys ProTrpIieThrArgGInAsnPheSerArgCysLeuG Lu Le uG 1 nC y sGI n ? r o As o S e r S e rT hr LeuG 1 yG 1 yG1 y S e rGI yG1 yG1 y S e rG1 yG1 yC- i y S e rG1 yG i yG L'/ SerGlyGiyGiySerGl’:/ThrGlnAspCysSe:r?heGlnHisSer ProIleSerSerAspPheAlaV’alLysI le ArgGluLeuSerAspTyrLeuLeuGlnAspTyrProvalThrVaiAlaSerAsnLeuGinAspGiuGluLeuCys GlyGlyLeuTrpArgLeuValLeuAiaGj-nArgTrpMetGiuArgLeuLysThrValAlaGlySerLysMetG In GlyLeuLeuGluArgVaiAsnThrGluIIeHisPheValThrLysCysAlaPhsGinPro SEQ ID NO:707 PMON3 57 9 5. pep > AiaThrProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeuLysSerLeuGiuGlnValArgLyslie GlaGlyAspGlyAlaAlaLeuGinGiuLysLeuCysAlaThrTyrLysLeuCysHisPrcGiuGiuLeuValLeu LeuG 1 y H i 3 S e r LeuG 1 y 11 e P r oT rp AI a ? r o L eu S e r S e r C y s ? r o S e r GI nA I aL euG 1 r\LeuA I aG L yC y s LeuSerGlnLeuHisSerGIyLeuPheLeuTyrGlnGlyLauLeuGlnAiaLeuGiuGlyIieSerProGluLen LeTrpGinGinMecGLuGiuLeu GlyMetAia?roAlaLeuGin?roThrGInGlyAlaMet:?roAlaP'neAia3erAla?heGInArgArgAlaGIy GlyValLeuValAiaSerHisLeuGInSerPheLeuGluVaiSerTyrArgValLeuArgHisLeuAiaGlnPi-o TyrVaiGluGlyGIyGIyGiySer?roGlyGlu?roSerGiy?rolleSerThrlLeAsnProSerProPrcSer LysGluSerHisLysSerProAsnMetAlaLeuGiaAspGiuGluLeuCysGlyGlyLeuTrpArgLeuValLe-a AlaGlnArgTrpMetiGIuArgLeuLysThrValAlaGiySerLiysMetGlnGlyLeuLeuGluArgValAsnThr ArgLeuLeuGlnGiuThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGloA.snPheSerArgCys LeuGluLeuGinCy〇GlnProAspSerSerThrLeuGlyGIyOIy5erGlyGlyGlySerGlyGlyGlySerGly GlyGlySerGlyGLyGlySerGlyThrGln.\spCys3erPheGlnHisSerProIleSerSerAspPheAlaVaL LysIleArgGluLeuSerAspTyrLeuLeuGinAspTyrProValThrVaiAlaSerAsn SEQ ID NO：703 pMON3 57 9 6. pep AlaThr?roLeuGIy?roAlaSerSerLeu?roGinSer PheLe'jLeuLysSerLeuGiuGlnVaiArgLys I L-2 LeuG1'/K isr kuG i'/ : iePrοTrpAiaPrcLeuSer :5erCys ?roSerG inA1 aLeuGi r丄euA1 aG1 yCy3 LeuSerGInLeuHisSerGiyLeuPheLeuTyrGlnG LvLeuLeuGiP^laLeuGIuGLyIleSerProGluLeu GiyProThrLeuAspThrLeuGlnLeuAspValAiaAspPheAidThrThrIleTrpGlnGInMecGluGluLeu GlyMecAla?roAldLeuGinProThrGlnGlyAlaMet.ProAiaPheAlaSerAla?heGlrLArgArgAlaGly G1 yVa i LeuVa 1 AidSerHis LeuG 1 nSer ?h“LeuG luVaLSerTyirAirgVcULeuArgH is LeuAlaG in Pro TyrVaiGluG LyGlyGLyGlySerProGLyGiuProSerGiyPro IieSerThrIieAsnProSer?ro?roSer

O:\92\92747.doc -250 - 200413407 !0 15

Ly sG 1 uSe r H i 3 L ys Se r P r oAs r.Me t A1 aG 1 ru\s pG luG 1 uLeuCy sG 1 yG i y LeuTrp Ar gLeuVa 1 LeuA 1 a GlriArgTrpMetiGiuArgLeuLysThrValAiaGlySerLysMeCGlnGlyLeuLeuGiuArgValAsnThrGIu LeuLeuGlnGLuThrSei:GiiiGlnLeu\/alAiaLeuLy3ProTrpI leThrArgGlnAsnPiieSerArgCysLeu GiuLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGly GlySerGlyGlyGlySerGlyThrGirL^spCysSerPheGInHisSerPrcIieSerSerAspPheAlaValLyG IleArgGiuLeuSerAspTyrLeuLeuGinAspTyrProVaiThrValAlaSerAsnLeu SEQ ID NO :709 ρΜΟΜ3 57 97. pep AlaThrProLeuGIyProAlaSerSerLeuProGlnSer PheLeuLeuLysSerLeuGluGlnValArgLyslie GlnGlyAspGiyAlaAiaLeuGlnGiuLysLeuCysAlaThrTyrLysLeuCysHis ProGiuGluLeuVaiLeu LeuGiyHisSerLeuGiylleProTrpAlaProLeuSerSerCysProSerGinAlaLeuGlnLeuAlaGiyCys LeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlr.GlyLeuLeuGlnAlaLeuGiuGIyIleSerProGluLeu 20 25

GlyPro'rhrLeuAspThrLeuGlnLeuAspValAlaAspPheAlaThrThrlieTrpGlnGlnKetiGluGluLeu GlyMetA.iaProAlaLeuGlnProThrGlnGiyAlaMetProAlaPheAlaSerAlaPheGinArgAirgAlaGly GlyValLeuVaiAiaSarHisLeuGlnSerPheLeuGluVaiSerTyrArgVaiLeuArgHisLeuAlaGlnPro TyrValGiuGIyGlyG LyGlySer?roGiyGlu?roSerGIy?roIleSerThrIieAsn?roSer?roProSer LysGluSerHisLysSerProAsnMecAlaGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlrJVrc; ΓΤ:τρΜθΙ:Ο1ιιΑΓ9ΐίβι<ιΙ·/γ3Τ1ΐ2：νΑΐΑΐαΟ1γ3βι:1^γ5Μβε〇1ηΟ1γ]110ΐιΙ^βυΟ1ιιΑΓ9ντ5ΐ]·Α3ηΤΐιι·〇1ιιΙ leHis PheVaiThrLysCysAlaPheGinPrcProProSerCysI^uArgPheValGlrvThrAsnlleSerArgLeuLeu GlnGiuThrSerGluGlnLeuValAlaLeuLysProTrpIIeThrArgGlr^snPheSerArgCysLeuGluLeu GlnCysGlnProAspSerSerThrLeuGlyGlyGiySerGlyGlyGlySerGlyGlyGl'/SerGlyGlyGlySer GlyGlyGiySerGlyThrGlriAspCysSerPheGlxnHisSerProIieSerSerAspPheAiaVaiLysIIeArg GluLeuSerAspTyrLeuLeuGinAspTyrProValThrValAlaSerAsnLeuGlnAsp SEQ ID N〇：710 PMON35793.pep

30 35

AlaThrProLeuGiyProAlaSerSerLeuProGlnSerPheLeuLeuLysSerLeuGluGinValArgLys：le GlnGlyAspGlyAIaAlaLeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHisProGIuGluLeuVaiLeu LeuGiyHisSerLauGlyrieProTrpAlaProLeuSerSerCysProSerGlnAlaLeuGInLeuAlaGlyCys LeuSerGlnLeuHisSerGlyLeuPheLeuTyrGInGlyLeuLeuGlaAlaLeuGluGlylleSerProGluLeu GlyProThrLeuAspThrLeuGlnLeuAspValAiaAspPheAlaThrThrlleTrpGIriGlraMetGiuGluLeu GlyMetAiaProAiaLeuGlnProThrGlnGiyAlaMetProAlaPheAlaSerAlaPheGlnArgArgAlaGiv GlyValLeuValAlaSerHisLeuGinSerPheLeuGluValSerTyrArgValLeuArgHisLeuAlaGlnPro 40

TyrVAlGluGlyGlyGlyGlySerPrcGlyGluProSeirGlyProIleSerThrllsAsnProSerProProSer LysGluSerHisLysSerProAsnMetAlaGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlr^rgTrp MetGIuArgLeuLysThrValAlaGIySerLysMetGinGIyLeuLeuGluArgValAsnThrGluIieHisPhe ValTnrLysCysAla?heGln?ro?ro?roSerCysLeuArg?heVaiGinThrAsnIleSarArgLeuLeuGla GluThrSerGIuGlnLeuV alAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGIn CysGinProAspSerSerThrLeuGiyGlyGiySerGIyGIyGlySerGlyGiyGlySerGiyGlvGlySerGly GlyGlySerGlyThrGinAspCysSerPheGlnHisSerProIIeSerSerAspPheAiaValLysIlsArgGl-a LeuSerAspTyrLeuLeuGlnAspTyrProValThrValAIaSerAsnLeuGInAspGlu SEQ ID NO：711 45 pMON35799.pep 50 60

AlaThr?roLeuGiy?roAlaSerSerLeuPrcGInSerPheLeuLeuLysSerLeuGluGInValArgLyslie G1 nG 1 y As cG I y A i aA 1 aLeuG 1 nG 1 u Ly s L e uC y 3 Λ1 aT h rTy r L y s L e uC y s H i s ? r oG 1 uG 1 uLe uVa 1L e u LeuGlyHisSerLeuGlylleProTrp^iaProLeuSerSerCysProSerGinAlaLeuGinLeuAlaGlyCys LeuSerGlr.LeuHisSerGiyLeuPheLeuTyrGInGlyLeuLeuGInAlaLeuGluGlylieSerProGluLeu GiyProThrLeuAspThrLeuGinLeuAspValAiaAspPheAlaThir.ThrlieTrpGi-iiGinMetGluGluLeu GlyMeCAIa?rcAIaLeuGin?roThrGInGIyAiaMet:?rcAia?heAlaSerAla?heGlr^rgArgAiaGiy Ty rVa iG 1 uG 1 yG1 yG i yG i y S e r Pr cG iyG I u P r o Se rG iy ? r ο 11 e S e rT hr 11 e Asn ?r c 3e r Pr〇 ? ro Ser LysGluSerHisLysSerProAsnMetAlaLeuCysGlyGIyLeuTrpArgLeuValLeuAlaGlnArgTrpMet G1 u A r g ^ e u L y s T h r V a i AI aG 1 y S e r L y s Me tG i nG 1 y L e u L e uG i u A r g Va i Λs nTh rGI u I i e H i s P h e Va 1 ThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGInThrAsp.IleSerArgLeuLeuGlaGlu ThrSerG - uGIr.LeuVaiAlaLeuLvs ProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGinCys GlnProAspSerSerThrLeuGiyGiyGiySerGIyGlyGlySerGlyGlyGlySerGlyGlyGivSerGiyGly G1 y S e rG i yT h r GI nAs pC y s S e r P heG 1 nH i 3 S e r P r ο 11 e S e r S e r As p ? he A1 a Va i L*/s 11 e Ar gG I uLe u SerAspTyrLeuLeuGinAspTyrProValThrValAlaSerAsnLeuGlp^.spGluGlu SEQ ID MO：712 PMOM39914.pep 、

65 70 75

AiaThr: Pro^euG i，/Pr〇i\iaSerSerLeuProG InSer PheLeuLeuLysSerLeuGluGlnValArgLys 11 e GinGiyAspdyAiaAlaLeuGir.GiuLysLeuCysAlaThrTyrLysL^uCysHisProGluGluLeuValLeu LeuGlyHisSerLeuGlylleProTrpAlaProLeuSerSerCysProSerGlaAlaLeuGlnLeuAlaGiyCys LeuSerGLriLeuHisSerGli/LeuPheLeuTyrGinGiyLeuLeuGip^AiaLeuGluGlvIieSerProGiuLeu GLyProThrLeuAspThrLeuGlp.LeuAspValAlaAspPheAlaThrThrlleTrcGinGlnHetGiuGluLeu GlyMer.A；aPrcAidLeuGinProThrGinGiyAiaMetProAla?h^Alab^rAia?heGir.ArgArgAlaGly GlyVaiLe^ValAlaSerHisLeuGlnSerPheLeuGluVaiSerTyrArgValLeuArqHisLeuAiaGlnPro TyrV.-uiG 1 JGlyG iyG lyGlySerProGlyGluProSerGiyProI leSerThrl leAsnProSerProPrcSer LysGluSerHisLysSerProAsnMetAlaAspGluGluLeuCysGLvGlyLeuTrpArgLeuVaiLeuAlaGin ArgTrpMenJluArgLeuLysThrValAlaGlySerLysMetGinGIvLeuLeuGluAraVdlAsnThrGluIie HisPh^VaiThrLysCysAiaPheGLnProProProSerCvsLeuArgPheValGlnThrAsnlleSerArgLeu O:\92\92747.DOC -251 - 200413407

LeuGlnGiuThrSerGLuGlnLeuValAlaLeuLysProTrpIleThrArgGInAsnPheSerArgCysLeuGlu LeuG LnCysGlnProAscSerSerThrLeuProProProTrpSerProArgProLeuGlyAlaThrAlaProThr T'hrGip^AspCysSerPheGlnHisSerProIleSerSerArspPheAlaVaiLysIleArgGluLeuSerAspT'/r LeuLeuGlaAspTyrProValThrValAiaSerAsnLeuGin SEQ ID MO：713 5 PMOM39915.pep

AiaThr?roLeuGiy?roAlaSerSerLea?roGinSerPheLeuLeuLysSerLeuGluGlnValArgLysIl-2 GlnGlyAspGlyAiaAIaLeuGlriGluLysLeuCysAlaThrTyrLysLeuCysHis PrcGluGluLeuValLeu 10 LeuGlyHisSerLeuGlyX ie?roTrpAia?roLeuSerSerCy3?roSerGIrLAlaLeuGlnLeuAlaGlyCys LeuSerGinLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlRAlaLeuGluGIyIleSerProGluLeu GlvProThrLeuAspThrLeuGInLeuAspValAiaAspPheAlaThrThrlIeTrpGlnGlm4etGluGiuLeu GlyMetAlaPrcAlaLeuGlnProThrGlnGIyAlaMeCProAlaPheAlaSerAlaPheGlnArgArgAlaGiy GiyValLeuV’alAlaSerHisLeuGlnSerPheLeuGluValSerTyrArgValLeuArgHisLeuAlaGlnPro 15 Tyr'/alGluGlyGiyGiyGlySerProGlyGiuPr〇SerGlyProI ieSer.Thr IleAsnProSerProProSer· LysGluSerHisLysSerProAsnMetAlaAspGluGluLeuCysGlyGIyLeuTrpArgLeuVaILeuAlaGln ArgTrpMecGluArgLeuLysThrvalAIaGlySerLysMetiGip.GIyLeuLeuGluArgValAsr.ThrGluIle HisPheValThrLysCysAlaPheGlnProPro?roSerCysL.euArgPheVaiGlnThrA5aIieSerArgLeu LeuGlnGluThrSerGluGinLeuVaiAlaLeuLys ProTrpIleT'hrArgGlnAsnPheSerArgCysLeuGlu 20 LeuGinCysGlaProAspSerSerThrLeuGlyGlyGlySe'rGlyGlyGlySerGlyGlyGlySerGlyGlyGLy SerGlyGiyGlySerGiyGIyGlySerGlyGlyGlySerGlyThrGlr^spCysSerPheGlnHisSerProIIe SerS<2rAspPheAia’'/aiLysIleArgGluLeuSerAspTyrIJeuLeuGlnj\spTyrPrcValTh::ValAlaSer AsnLeuGln SEQ ID NO :714 25 ρΜΟΜ3931β.pep

AlaThr ProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeuLysSeirLeuGiuGln'/aiArgLysIle GlnGlyAspGlyAlaAiaLeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHis PrcGluGluLeuValLe1」 ^ LeuGlyHisSerLeuGlylleProTrpAlaProLeuSerSerCys ProSerGlnAlaLeuGlnLeuAlaGlvCys 30 LeuSerGlnLeaHisSerGIyLeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlylleSerPrcGIuLeu GiyPro-ThrLeuAspThrLeuGInLeuAspValAlaAspPheAiaThrThrlleTrpGinGIrJ-lecGluGluLeu GlyMetAia?roAlaLeuGlnPrcThrGlnGlyAlaMetProAla?heAla5erAia?heGlnArgArgAlaGly GiyVaiLeuValAlaSerHisLeuGlnSerPheLeuGiuValSerTyrArgValLeuArgHisLeuAlaGinPro ” TyrValGiuGlyGlyGiyGlySerProGlyGluProSerGlyProlIeSerThrIleAsnProSerProProSer 35 LysG luSer Hi s ILeuAlaGln

ArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGiuArgValAsnThrGluIle HisPheValThrLysCysAlaPheGinProProProsirCysLeuArgPheValGlnThrAsnlIeSerArgLeu LeuGlnGluThrSerGluGlnLeuValAIaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGlu Ι^θΐι〇]_ηΟ’；/3〇]·ηΡ2：οΑ；3ρ3θ：Γ5θΐ:ΊΊΊ2Γΐβ1·αΡ2：οΡΓ〇Ρ；Σ：οΤ：Γρ50；ΓΡι·〇Αι：9Ρ:*·〇Ι^ΘΐιΟ1γΑ]ΐΑΤΐι：ΓΑΐ<5ΐΡ：Γ〇ΤΐΊΓ 40 AlaGlyGinPro?roLeuThrGinAspCysSer?heGlnHisSer?roIieSerSerAspPheAlaVaiLysIie ArgGiuLeuSerAspTyrLeuLeuGln^.spTyrProVaiThrValAlaSerAsnLeuGln SEQ ID NO :715 piMON3 57 12 .oeu 45

AlaAspTyrProVallrVaLAlaSerAsnLeuGlnAspGluGliiLeuCysGli/GlyLeuTrpArgLeLiValLeu A1 aG 1 nAr gT rpMe tG 丄 uArgLeuLysThr V，a i A1 aG 1 yS erLysMe CG i nG 1 y Leu L euG 1 uArg'/a 1 As nrr:n r GiuIleHisPheValThrLysCysAlaPheGInProProProSerCysLeuArgPheVaiGlnThrAsnlleSer _ ArgLeuLeuGlnGiuThrSerGluGia'LeuValAlaLeuLysProTrpIieThrArgGlnAsnPheSerArgCys 50 L e uG 1 υ L e uG 1 nC y s G1 n ? r o As p S e r S e r T h r L e uG i y G l y GI y S e r GI y〇 -· 1 y S e r G1 yG I y G i y S e r GI y G1 yG 1 y T hr G1 nA 〇 pCy s S e r ? heG lr.HisSerProlieSer S er As p ?heA 15-V a IL y 311 e Ar gG luLeuSer AspTyrLeuLeuGln SEQ ID MO：7 L6 PMOM35713.oep 55 A1 a A l a S e n Le uG 1 rAs pG 1 uG 1 uL e uC y s G WG1 v L eu.T rc Ar.g L 2 u 7 a 1L e u A i aG 1 nArgT rp Me t G L u

ArgLeuLysThr'MiAiaGiySerLysMetGlnGV;.LeGLeuGi^rgVaLMnThrG^

SerG LuG lrXeu'/a iA.laLeuLys ProTrO J： LeThr ArgG IriAsriPheSerAr gCysLeuGiuLeuG IriCysG La 60 ProAspSerSerThrLeuGiyGiyGlySerGiyGiyGiySerGiyGlyGlySerGlyGlyGiyThrGlr^spCys

SerPheGInHisSerProIieSerSerAspPheAlaValLysIieArgGluLeuSerAspTyrLeuLeuGir^sp TvrProVaiThrVai SEQ ID N〇:717“ " ^ ^ DMON35714.oeo 65

AlaValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGiuIleHisPheValThrLysCysAia PheGir^ProProProSerCysLeuArgPheValGinThrAsnlleSerArgl-euLeuGInGluThrSerGluGln LeuVaiAiaLeuLysProTrp I leThrAraGlp.AsaPheSer-AraCv3LeuGluLeuGinCysGln?roA5pSer SerThrLeuGlyGlyGLySerGlyGlyGlvSevGlvGlyGly'SerGivGlyOiyThrGip^.spCysSerPheGLn 70 HisSerPrcIUSerSerAspPheAIaValLysIieArgCiuLeu^erAsp^yrLeuLeuGlnAspTyrProVaL Th rVa 1Λi aSe r As nLeuG I r.As pG i uG IuLeuCvsG I vG I y LeuT roArg^eu1 LeuA1 aG 1 ru-\rgT rpMe c GLuAirq^euLz/sThr· SEQ ID MO :713 』 ^ 、 PMON3 57 15 . 75 、 O:\92\92747.DOC 252 - 200413407 ΑΐΑ50Γΐ//3Μβ£σΐ：ν3ν/Γ^θΐιΙ·2ΐιΟ1·ΐιΑΓ9νΑΐΑ·3ηΤ1ΐΓ〇1υηθΗί_：3ΡΐΊθ'/βΐτΗΓ·τυ：/：3〇/3Αΐ5ΐΡΐΐθΟ1η?Γ〇 PrcPiroSerCysLeuArgPheVaiGLnThrAsnl leSerArgLeuLeuGlnGLuThrSerGiuGlnLeiiVaiAia LeuLysProTrpI leThrArgGinAsnPheSerArgCysLeuGluLeuGinCysGlnProAspSerSerThrLeu σΐγ〇ίν<^'/56Γ〇1·，/σΐγσ：1，/30Γΰ1γΟ1·γσΐ'/5θ：^1^1ι/Ο1’/ΓΐΐΓσΐΓΐΑ3ρε*/；3 5θΐ·ΙΡΐ^Ο：ΙηΗί5 5θ2：?Γ〇 5 IleSerSerAspPheAlaValLys I ieArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAla SerAsnLeuGlaAspGluGiuLeuCy〇GiyGlyLeuTrpArgLeuVaiLeuAlaGln.ArgTrpMet:GluArgLeu LysThrValAlaGly 5EQ ID N〇：719“ pMCM3 5 7 1β. pep 10

AlaProProSerCysLeuArgPheValGlnThrAsnlleSerArgLeuLeuGlnGiuThrSerGluGlnLeuVal AiaLeuL73?roTrpIleThrArgGiriAsnPheSerArgCysLeuGluLeuGln.CysGln?roAspSerSerThr LeuGi'/Gli/GlySerGlyGlyGiySerGlyGlyGlySerGlyGlyGlyThrGlnAspCysSerPheGlnHisSer ProlLeSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrVal {5 MaSerAsnLeuGloAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArg LeuLysThr'/alAiaGlySerLysMetGinGlyLeuLeuGluArgValAsnThrGldeHisPhe'/aiThrLys CysAlaPheGinPro 5EQ ID N〇：720 " pMCM3 5 717.peo 20 '

AlaArgPheValGlnThrAsnlleSerArgLeuLeuGinGiuThrSerGluGlnLeuValAlaLeuLysProTrp I le.ThrArgGlaAsnPheSerArgCysLeuGluLeuGinCysGlnProAspSerSerT'hrLeuGlyGiyGiySer GlyG IvG1yS e rG1yGIvG i yS erGIyG1yG1yThrG1 rj^s pCys Se r PheGInHisSerProlieSerSerAsp PheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrPr〇’\/alThrV*alAlaSerAsnLeuGln 25 AspGluGiuLeuCysGlyGIyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAia

GlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGiuIleKis PheVaiThrLysCysAlaPheGinPrc PrcProSerCysLeu SEQ ID NO :721 〇MON3 5713. cep 30

AlaThrAsnlleSerArgLeuLeuGlnGluThrSerGluGinLeuValAiaLeuLysProTrpIleThrArgGln AsnPheSerArgCysLeuGluLeuGinCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySer GlyGlyGlySerGlyGlyGlyThrGinAspCysSerPheGinHisSerPrcIleSerSerAspPheAlaValLys ” I leArgGluLeuSerAspTyrLeuLeuGirLA.spTyr ProValThrValAlaSerAsnLeuGlnAspGluGluLeu 35 Cy sG 1 yGlyLeuTrpArgLeuValLeuA I aGloArgTrpMetGluArgLeuLysThrValAlaGlySerLysMec

GlnGlyLeuLeuGiuArgVaiAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCys LeuArgPheValGin SSQ ID NO :722 一 40

PMOM3217G.pep 45 50 60 65 70

AlaAspGiuGluLeuCysGlyGlyLeuTrpArgLeuValLeuAiaGinArgTrpMetGluArgLeuLysThrVai AlaGlySerLysMetGlnGiyLeuLeuGluArgValAsnThrGluIlsHisPheValThrLysCysAlaPheGIn Pro ProProSerCysLeuArgPheValGlnThrAsnlieSerArgLeuLeuGlnGluThrSerGluGlnLeuVdl AlaL’uLysProTrplleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThr LeuGiyGiyGiySerGlyGlyGiySerGlyGlyGlySerGlyGlyGiySerGlyGlyGlySerGlyThrGlaAsp CysSer?neGlnKisSer?roIleSerSsrAsp?heAlaValLysIleArgGluLeuSerAspTyrLeuLeuGin AspTyr ProValThr7alAlaSerAsn.LeuGlnTyrValGiuGlyGlyGlyGIySerProGlyGLuProSerGi·/ Pro -sSerThr i leAsnProSer Pro-ProSerLysGluSerHisLysSer ProAsni4e cAlaThrProLeuGly ProAiaSerSerLeuProGlnSerPheLeuLeuLysSerLeuGluGlnValArgLysIieGlnGl'/AspGlyAla A1 aueuG i r.G 1 uLy s Le uCy s ΛI aT hrTy r Ly s LeuCy s H i s ? r oG 1 uG 1 uLeuVa 1 Le u LeuG 1 yH i 3 S e r Leu Glyi^eProTrpAlaProLeuSerSerCysProSerGInAlaLeuGlnLeuAlaGlyCysLeuSerGlnLeuHis SerGlyLeu?heLeuTyrGinGlyLeuLeuGlnAlaLeaGIuGlyIleSer?roGiuLauGly?roThrLeuAsp Thr LeuG i. nLeu Asp ·./ a i AI aAs p P he Ai aThrThr 11 eT rpG 1 r.G I ni4e tG I uG I aL euG 1 y Me t Al a ? r oA i a u e u G i n ? r ο T h r G1 n g 1 y Λ i a M e t: ? r o AI a ? h e Λ i a S e r A1 a ? a e G1 nA r a A r a A1 a GI v G1 y V a IL e u V a 1Λ L a SerHisLeuGinSerPheLe^GiuValSerTyrArgVaiLeuArgHisLeuAiaGlnPro SEQ ID NO：723 PMCM321S7.peppiaGt'ySer- /SMeCG^nG""/LeuLeuG'!'uArgVa'!LAsrLT，rirG'1'uI^eH^s?*rieVaiTirirL^sCysAla?^eGin .roPrcProberCysLeuArgPheValGinThrAsnlleSerArgLeuL^uGlnGluThrSerGluGlnLeuVaL AlaLeuLysProTrpi iexpiri\rgG].nAsnPheSerArgCysLeuGluLeuGlnCysGlnPrcAspSerSerThr $ e u(^ 1 y G i y g y s e r G i y G i yG 1 y S e i:G 1 y G L y G i y S e rrG i yG i yG 1 y S e rG 1 yG 1 y G1 y S e i:G L yT h i:G 1 nAs p fys 三 er?he。:丄▽Hiss er?ro I ieSerSerAspPheAlaVaiLys I ieArgGluLeuSerAspTyrLeuLeuG In P 2 r ? r c 二 a 1 r 1A1 a S e r As n L e uG i nT y i: '/a 1G1 uG i y G1 y G ly G1 y S e r P r o G i y G1 u P r o S e r G i ：/ \Τ〇Αiab.er；:：erLeu?rcG ^-nSer pheLeuLeuL，/sCYs luGlaValArgLys 11 eGlnGlyAspG lyAla AlaLeuG In-〇 LuLysLeuC'/GAiaThrTyrLysLeuCysHis ProGiuGluLeuValLeuLeuGiyHisSerLeu 5. :/ 上 Γ e ? Γ 〇 : Γ P十丄 d P r 0 ^ u S 占 r S e r C V，s P r 〇 S e r G i 1 a L e u G i n L e u A1 a G1 v，C y s L e u S e r G1 n L e u H i s ^er^i.'/L.euPhe^euTyrGinGi vLeuLeuGIaAiaLeuGluGlyl leSerProGluLeuGlyProThrLeuAsp ^ -P^eu*^3pva lAiaAspPheAlaThrThr IleTrpGlnGlnMetGluG LuLeuG I'/MeCAiaProAla Leuuia?roThrGiaGIyAIaHecProAla?heAlaSerAlaPheGlp^rgArgAlaGlyGlyValLeuValAld berHisLeuGinSerPheLeuGiuValSerTyrArgValLeuArgHisLeuAlaGlnPro SEQ ID MO :724

-253 -

O:\92\92747.DOC 200413407 …pMON32271.pep

AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuvaiLeuAiaGir^rgTrpMetGluArgLeuLysThrVal AlaGIySerLy5MetGlnGlyLeuLeuGiuArgVaiAsnThrGiuIieHi3?heValThrLysCysAiaPheGLa 5 ProProProSerCysLeuArgPheValGinThrAsnlleSerArgLeuLeuGlnGluThrSerGluGlnLeuVai AlaLeuLysProTrpIleThrArgGinAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThr LeuProProProTrpSerProArgProLeuGlyAlaThrAla?roThrAlaGlyGln?roProLeuThrGla*\sp CysSerPheGlnHisSerPrcIleSerSerAspPheAlaValLysIleArgGiuLeuSerAspTyrLeuLeuGln AspTyrProValThrValAlaSerAsaLeuTyrValGiuGlyGlyGIyGlySerProGlyGIyGlySerGlyGly i 〇 GlySerAsnMetAlaThrProLeuGlyProAlaSerSerLeu?roGlnSer?heLeuLeuLysSerLeuGluGln

ValArgLys IleGlnGlyAspGlyAlaAlaLeuGinGluLysLjeuCysAlaThrTyrLj/sLeuC'/sHisProGJLu GluLeuValLeuLeuGlyHisSerLeuGlylleProTrpAlaProLeuSerSerCys ProSerGIrLAlaLeuGin LeuAlaGlyCysLeuSerGlnLeuHisSerGiyLeuPheLeuTyrG inGIvLeuLeuGinAlaLeuGluGlyIle SerProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAlaThrThrIleTrpGinGin 15 MecGluGluLeuGlyMetAIaProAlaLeuGlnProThrOlnGlvAlaMeCProAlaPheAlaSerAiaPheGΙα

ArgArgAlaGlyGlyValLeuValAiaSerHisLeuGlp.SerPheLeuGluValSerTyrArgValLeuArgHis LeuAlaGlnPro SEQ ID NO：725 oM〇N3 2 27 2. pep 20

AlaAspGluGluLeuCysGiyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrVal AlaGlySerLysMetLGinGlyLeuLeuGluArgV-alAsn.ThrGluIleHisPheValT’nrLysCysAiaPheGln ProProProSerCysLeuArgPhe'/alGlnThrAsnlleSerArgLeuLeuGlnGluThrSerGluGlnLeuVai AlaLeuLys?rGTrpIleThrArgGlnAsn?heSerArgCysLeuGluLeuGinCysGlnProAspS<erSerThr 25 LeuGlyGlyGiySerGlyGlyGlySerGlyGlyGlySerGlyGlyGiySerGlyGlyGlySerGlyGlyGlySer GlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAla/'/aiLys 工 ieArg GluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAiaSerAsnLeuGlnTyrValGiuGiyGlyGly GlySerProGlyGlyGIySerGlyGlyGlySerAsnMetAiaThrProLeuGiyProAlaSerSerLeuProGln Ser?heLeuLeuLysSerLeuGluGlnValArgLysIleGlnGlyAspGlyAlaAlaLeuGlr:GluLysLeuCy3

SerSerCysPrQSerGinAlaLeuGlnLeuAlaGIyCysLeuSerGlnLeuHisSerGLyLeuPheLeuTyrCTln GlyLeuLeuGlnAlaLeuGluGi'/IleSerProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspValAla AspPhsAiaThrTxhrlleTrpGlnGlaMecGluGluLeuGIyMeCAlaProAlaLeuGlnPrcThrGlnGiyAla Met?raAiaPheAlaSerAla?heGlaArgArgAiaGlyGlyVaiLeuVaiAIaSerHisLeuGlnSer?heLeu 35 G1uVa1SerTyrArgVa1LeuArgHisLeuA1aGIn?ro SEQ ID NO：72β pMON32274.pep 40 AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGl^rgLeuLysThrVai

ProProProSerCysLeuAirgPheValGlnThrAsnlleSerAirgLeuLeuGlnGluThrSerGluGlnLeuVa-l AlaLeuLys ProTrpIleThrArgGinAsnPhsSerArgCysLeuGluLeuGInCysGlnPrcAspSerSerThr Leu?ro?roProTrpSerProArgProLeuGiyAlaThrAlaPrcThrThrGInAspCysSerPheGlnHisSer 45 ProIieSerSerAspPheAlaVaiLysIleArgGluLeuSerAspTyrLeuLeuGinAspTyrProValThrVai A1 a S e r A s n L e uTy r Va 1G1 uG I yG I yG 1 yG 1 v S e r ? r o G1 yG 1 yG I y S e rG I yG 1 yG 1 y S e r A s rJ-ie t A1 aT h r ProLeuGi'/ProAlaSerSerlieuProGlnSer PheLeuLeuLY.sSerLeuGluGJLnValArgLys 工 leGlnGly AsdGiyΛΙaAIaLeuGInG1uLysLeuCysAlaThrTyrLysLeuCysHis ?rcGIuG LuLeuv a1LeuLeuG Ly HisSeirLeuGiylieProTrpAlaProLeuSerSerCi/sProSeirGlnAlaLeuGlnLeuAlaGlyCysLeuSer 50 GinLeuHisSerGiyLeuPheLeuTyrGlnGiyLeuLeuGir^\IaleuGiuGIyIieSer?raGluLeuGly?ro Thr LeuAs pThr LeuG 1 nLeuAspVa 1A laAs p PheAl aThrTh:: I i eTrpG 1 p‘G i aMe tG 丄 uG i uLeuG 1 yMe c A1 a ? r o A i a L e uG 1 η P r ο T h r G1 nG 1 y A1 aMe t: ? r o A1 a ? h e A1 a S e r A1 a ? h eG i Ar g Ar gΛI aGI yG i y V -a 1 LeuVa 1Aia:5erH i sLeuG 1 nSer PheLeuG 1 uVa 1SerTyrAr*g'/a 1LeuArgHi sLeuA丄aG ηP::o SEQ ID MO：7：7 55 pMOM3 57 5 1. pep Λ1 a As pG i uG I u L euCy s G1 y G1 y Le uT r pAr g L e uVa 1L a u A i aG 1 nAr gT r pMe tG L a Ar g L e u Ly 3 Th r Va i AlaGiySerLysMetGlnGiyLeuLeuGiuArgValAsnThrGluIleHisPheVaiThrLysCysAiaPheGiri 60 Pr〇ProProSerCy3LeuArg?heValGLnThrAsnIleSe;cAi:,gLeuLe\jGlnGluThrSei：G luGinLeu'/ai AlaLeuArgProTrp 'I LeThrArgGlaAsnPheSerArgCysLeuGluLeuGinCysGlnProAspSerSerThr LeuGLyGLyGiySerGlyGiyGlySerGIyGlyThrGip^spCysSerPheGlnHisSerProIleSerSerAsp PheAlaVaiLysI.UAr^ikeGserAsp'TyrLeuLeuGirAspTyr?F〇ValThr'/alAla;9eL'\snLeiiGin 65 LysGluSerHisLysSer?roAsnMecAlaThr?roLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeu L y s C y 3 L e uG 1 uG i η V a i A r g Ly s 11 eG 1 nG 1 y Λ s pG 1 y A1 a A i a L e uG 1 nG 1 u L y s L e uC y s AI aT h r T y r L y 3 LeuCysHisProGliiGiuLeu'/aJLLeuLeuGiyHisSerLeuGiy I ieProT'rpAiaProLeuSerSerC'/s Pro S e r G i rir\ i a L 己 uG 1 n L eu A1 aG 丄 y C y s L e u S e r G i n L e u H i s S e r G i ：/ L e u P he L e uT v. i: G1 nG 1'/ L e u L e uG i n AlaLeuGluGlylieSerProGiuLeuGiyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAlal'hr 70 Th r I i eT r pG i nG 1 nMe ^:01 uG I u L euG lyMe c AI a ? r o AI a LeuG I n ? r oT hrG1 nG i y Λ i aHe ϋ ? r o AI a ? h e

AldSer.Ud?heGinArqArgAlaGl,/GiyValLeu:/aiAiaSerHisLeuGinSerPheLeuGiuVaiSyTv,r ArgVa LLeuArgHisLeuAiaGinPro SEQ ID MO：72 S oMOMJ 57 5 ?. . cep 75 ' -254-

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AlaAspGluGiuLeuCysGlyGiyLeuTrpArgLeuValLeuAiaGlaArgTrpMetGluArgLeuLyoThrVal AlaGl/SerLysMe t:G InG IvLeuLeuG 1 uArg'/a lAsnThrG iu 11 eHi s PheValThrLysCysAiaPrieG In ProProProSerCysLeuArgPheValGlnThrAsnlLeSerArgLeuLeuGlnGluThrSerGluGlnLeuVal AlaLeuLys ProTrpI LeThrArgCLnAsaPheSerArgCysLeuGluLeuGinCysGiaProAspSerSerThr 5 LeuGlyGLyGlySerGlyGiyGlySerGlyGlyGIySerGiyGiyGlyThrGInAspCysSerPheGLnHisSer ProIIeSerSerAspPheAiaValLyoIleArgGluLeuSerAspTyrLeuLeuGl aAs pTy r ? r o Va 1T h r V a i AlaSerAsnLeuGlnTyrValGluGlyGlyGlyGlySerProGlyGiaProSerGlyProI leSerThr I leAsn ProSer ProProSerLysGluSerHisLysSer ProAsnMetiAIaThr PrcLeuG.ly?roAlaSerSerLeu?ro GlnSer PheLeuLeuLysCysLeuGluGlnValArgLys I leGinGlyAspGlyAiaAlaLeuGinGluLysLeu 10 CysAlaThrTyrLvsLeuCysHis ProGluGIuLeuValLeuLeuGlyHisSerLeuGly IleProTrpAlaPro

GlnGlyLeuLeuGloAlaLeuGluGLylleSeirProGluLeuGiy ProThzrLeuAspThrLeuGlnLeuAsp'/ai AlaAspPheAlaThrThr HeTrpGlnGinMet:GluGiuLeuGlyMet:Ala?roAlaLeuGln?roThrGlnGly AlaMetProAiaPheAlaSerAiaPheGlnArgArgAiaGlyGlyValLeuValAlaSerHisLeuGlnSerPhe I 5 LeuGIuVa 1SerTyrArgVaiLeuArgHIsLeuAlaGlnPro SEQ ID MO :729 pMON35753.pep

AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAiaGlriArgTrpMetGluArgLeuLysThrVai

ProProPrcSerCysLeuArgPheValGirLThrAsnlieSerArgLeuLeuGinGluThrSerGiuGinLeuVai AlaLeuLys ProTrp I XeThrArgGIr^sriPheSerArgCysLeuGluLeuGinCysGlnProAspSerSerThr LeuGlyGlyGlySerGiyGIyGiySerGlyGlyGiySerGiyGIyGlySerGiyG：yGlySerGlyThrGin.\sp CysSerPheGlnKisSerProIleSerSerAspPheAlaValLys I leArgGluLeuSerAspTyrLeuLeuGin 25 AspTyrProValThrValAiaSerAsnLeuGlp/TyrValGJLuGiyGlyGlyGlySerProGlyGluProSerG 丄:./

ProIIeSerThr IleAsnProSerPro?roSerLysGluSerHisLysSerPr〇i\snMecAlaTh.r ProLeuGiy ProAlaSer SerLeuPr 1 leGinGlyAspGlyA 丄 a

AlaLeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHis PrcGiuGluLeuVaiLeuLeuGIyHisSerLeu GlylleP'roTrpAlaPrGLeiiSerSerCysProSerGlnAlaLeuGlnljeuAlaGlyCysLeuSerGlnLeuHis 30 SerGIyLeuPheLeuTyrGInGlyLeuLeuGlnAlaLeuGluGlylleSerProGluLauGIyProThrLeuAsp Thr LeuG InLeuAspVa iAiaAsp PheAlaThrThr 11 eTrcG InG lai-!e tG LuGluLeuG lyMe tAlaPro Ala LeuGin?roThrGlnGlyAlaMetProAia?heAlaSerAia?heGlnArgArgAlaGiyGiyValLeuValAla SerHisLeuGlnSerPheLeuGluValSerTyrArgValValArgHisLeuAiaGinPro SEQ ID NO :73 0 35 pMON35754.pep

AlaProProSerCysLeuArg

AlaLeuLys ProTrp I leThrArgGInAsnPheSerArgCysLeuGluLeuGlnCysGInPrcAspSerSerThr LeuGlyGiyGlySerGiyGlyGlySerGlyGiyGlySerGiyGlyGlyThrGlaAspCysSerPheGInHisSer 40 ProIleSerSerAspPheAlaValLysIIeArgGluLeuSerAspTyrLeuLeuGlnAspTyrProVaiThrVai AlaSerAsaLeuGlnAspGluGiuLeuCysGlyGlyLeuTrpArgLeuVaiLeuAlaGlnArgTrpMetGiuArg LeuLysThrValAlaGiySerLysMecGInGlyLeuLeuGi'dArgValAsnThrGluIleHisPheValThrLy.?, CysAiaPheGinProTyirValGluGlyGlyGlyGlySerProGlyGluPrroSeirGlyProIleSerThrlleAsn _ ProSerProProSerLyGGluSerHisLysSerProAsnMetAiaThrProLeuGlyProAlaSerSerVaiPro 45 GlnSerP’neLeuLeuLysCysLeuGluGln'/alArgL'/sIleGlnGlyAspGlyAlaAlaLeuGiriGiuLysLeu CysAlaThrTyrLysLeuCysHisProGluGiuLeuValLeuLeuGIyHisSerLeuGlylleProTrpAiaPro LeuSerSerCysProSerGinAlaLeuGInLeuAlaGlyCysLeuSerGinLeLiHisSerGlyLeuPheLeuTyr GlnGlyLeuLeuGlnAlaLe^GluGlylieSerProGiuLeuGlyProThrLeuAspThrLeuGinLeuAspVai _ AlaAspPheAlaThrThrlieTrpGinSlniMetGluGluLeuGiyMetAlaProAiaLeuGinPrcThrGlnGly

50 AlaMet?roAla?heAlaSerAla?heGir.ArgArgAiaGiyGiyVaiLeuValAlaSerHi3LeuGlnSer?he LeuGluValSerTyrArgVailiaArgHisLeuAlaGinPro SEQ ID NO :731 pMON3 57 5 5. pep 55 AlaSerAsnLeuGlr.AspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAiaGInArgTrpMetGiuArc L e u L y 3 T h r a IA1 a GI y S e r L y s M e c G i n GI y L e u L e u G ： u A r g V a 1A 5 η T h r G1 u I i e H i 3 P h e V a i T h r L y ：:； C’/sAiaPheGln?r〇ProProSerCysLeuArgPheValG]_nThrAsriI ieSerArgLeuLeuGinGluThrSe:: G1 uG i n L e u i A1 a L e u L· ys ? r ο T rp 11 e T h rAr gG 1 nAs n ? h e S e rAr gC ν' s L e uG 丄 u L e uG 1 nCys G i n ? r As p S e r S e r T h r L e uG i y G1 y G i y S e r G1 yG 1 y GI y S e r GI y G1 yG I y S e rG 1 yG 1 yG i y S e r G1 y G1 '/〇 ly3^ r 60 GiyT'hrGlnAspCysSerPheGiriHisSerProIieSerSerAspPheAla'/alLysneArgGluLeuSerAsp TyrLeuLeuGInAspTyzrPrcValThrValAlaTyrVaiGiuGlyGlyGiyGiySerPiroGjLyGluProSerGly ProIlsSerThr IleAsnProSerHisProSerLysGluSerHisLysS^rProAsr^IetAlaThrProLeuGL·/ ProAlaSerSerLeuProGlnSerPheLeuLeuLysCysLeuGluGinValArgLysIleGlnGlyAspGlyAIa _ AlaLeuGlnGluLysLeuC'/sAlaThrTyrLysLeuCysHis ProGluGluLeuValLeuLeuGlyKiGSerLeu 65 Glyl Ie?roTrpALa?rcLeuSerSerCys?rv〇SerGLnAiaLeuGlnLeuAlaGLyCysLr3uSerGlnLeuHi3

SerG iy Leu Phe LeuTy rG 1 nG ly Leu LeuG inAl a LeuG iuG ly 11 eSe r ?r oG LuLeuG i γ P roThr LeuAsp Ί1 h r L e uG i π L e u A s p Va 1A i_ a A s p P h e A1 aT h r T h r I i eT r pG 丄 nG 1 e t G i u G1 u L e uG i y M e C A1 a ? r o A i a L e uG 1 η P r oT h r G i nG i y Λ1 aMe t ? r 0Λ1 a ? he A1 a S e r A1 a ? ；n eG i r gAr g A i aG 1 y GI y Va IL e u Va 1Λ1 a Ser H i 13 LeuG 1 r.S er PheLeuG I uVa 1 SerTyrArgVa LLeuAraH is LeuAlaG I a Pro SEQ ID NO ： 7 3 2 70 ^ pMOMi 5 T 5 5. pep

AlaAsnLeuCInAspGiuGluLeuCysG lyGlyLeuTrpArqLeuValLeuAiaGinArgTrpMeciGluArgLeM L·/ s T h r V jl 1A i a G L·/ S e r L·/ s M e t G i n G i y· L e u L e u G1 u A r g'/ a L A s η T h r G L u IL e H l s ? e V a 1T h r L y s C y s 75 AiaPheG Lr:Pro Pro ProSerCysLeuA:rg PheV’alGlnThrAsnl ieSerAfgLeuLeuGlnG luThrSerG

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GlnLeuVa lAiaLeuLys ProTrpI leThrArgGioAsnPheSerArgCysLeuGluLeuGlnCysGlnProAsp SerSerThrLeuGlyGl'/GlySe‘rGlyGlyGlySerGiyGiyGlySerGlyGl*yGiySerGlyGlyGlySerGly ThrGlnAspCysSerPheGinHisSerProIleSerSerAspPheAlaValLys!leArgGluLeuSerAspTyr LeuLeuGlnAspTyrProValThrValAlaSerTyrValGluGlyGlyGlyGiySer?roGlyGlu?roSerGIy 5 Pro!leSerThrIleAsnProSerProProSerLysGluSerHisLysSerProAsnMetAlaThrProLeuGiy ProAlaSerSerLeu?roGlnSer PheLeuLeuLysCysLeuGliiGln'/alArgLysI leGlnGlyAspG 丄yAlci AlaLeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHisProGluGluLeuVaiLeuLeuGlyHisSerLeu GlylleProTrpAiaPrcLeuSerSerCysProSerGlaAlaLeuGinLeuAlaGlyCysLeuSerGlnLeuHis SerGlyLeuPheLeuTyrGlnGIyLeuLeuGl〇-\laLeuGluGlyIIeSerProGluLeuGlyProThrLeuAsp 10 ThrLeuGlnLeuAspValAlaAspPheAlaThrThrIleTrpGInGlnMetGiuGluLeuGlyMeCAlaProAIa LeuG 1 n ? r oThrG 1 nG 1 y A i aMe c?r〇 A laPhe A laSer A laPheGl nArgAr g A1 aG 丄 yG 1 '/Va 1L euVa 1A1 a SerHisLeuGinSerPheLeuGluValSerTyrArg'/allleArgHisLeuAlaGlnPiro SEQ ID M〇：73 3 pM〇N35757.Oep 15 "

AlaLeuGlnAspGluGluLeuCysGlyGl7LeuTrpArgLeuValL·euAiaGinΛrgLeuMetGluArgLeuL·ys ThrValAlaGlySerLysMecGlnGlyLeuLeuGluArgVaiAsnThrGluIieHisPheValThrLysCysAla PheGlnProProProSerCysLeuArgPheVaiGlnThrAsnlieSerArgLeuLeuGlnGliiThrSerGluGin LeuValAlaLeuLysProTrpIieThrArgGInAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSer 20 SerThrLeuGlyGlyGlySerGIyGlyGIySerGlyGlyGiySerGlyGlyGIySerGlyGlyGlySerGlyThr

LeuGlaAspTyrProValThrValAiaSerAsnTyrValGluGlyGlyGIyGlySerProGlyGluProSerGly ProIleSerThrIlsAsnProSerProProSerLysGIuSerHisLysSerProAsRMetAlaThrProLeuGly ProAlaSerSerLeuProGlnSerPheLeuLeuLysCysLeuGluGlnValArgLysIleGlnGlyAsOGlyAia 25 AlaLeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHisProGluGlLiLeuVaiLeuLeuGlyHisSerLeu GiyllePro.TrpAlaProLeuSerSerCysProSerGlnAlaLeuGlnLeuAiaGlyCysLeuSerGlnLeuHis SerGlyLeuPheLeuTy.i-GlnGlyLeuLeuGlnAlaLeuGluGlylleSerProGluLeuGlyProThrLeuAsp ThrLeuGlnLeuAspVaiAlaAspPheAlaT'hrThr IleTrpGlnGirLMezGluGluIjeLiGlyMecAlaProAia LeuGlnProThrGlnGlyAlaMecProAlaPheAlaSerAlaPheGlnArgArgAlaGlyGlyValLeuValAId 30 SerHisLeuGlnSerPheLeuGluValSerTyrArgValLeuArgHisLeuAlaGlnPro SEQ ID NO :734 CMON3 57 53. pep 35 LysMetGinGiyLeuLeuGluArgValAsnThrGluIleHis?heVaIThrLysCysAiaPheGlnPro?ro?ro SerCysLeuArgPheValGlriThrAsnlleSerArgLeuLeuGirLGluThrSerGiuGlnLeuValAlaLeuLys ProTrpIieThrArgGlnAsnPheSerArgCysLeuGiuLeuGln.CysGIn?roAspSerSerThrLeuGIyGiy G1 y S er G lyG 1 yG 1 y SerG 1 yG 1 yG iy Ser G1 yG I yG I y S erG lyG lyG i y SerG 1 yThrG 1 nAspCys Ser ?he GlnHisSerProlleSerSerAspPheAlaVaiLys!leArgGIuLeuSerAspTyrLeuLeuGlnAspTyrPro 40 ValThrVaiAlaSerAsnLeuGlnAspGIuGIuTyrValGiuGIyGlyGlyGlySerProGlyGluProSerGly ProIleSerThrIleAsnProSerProProSerLysGluSerHisLysSer?roAsnMetAlaThr?roLeuGIv ProAlaSerSerLeuProGlnSerPhelieuLeuLysCysLeiiGluGlnVaiArgljys IleGlnGlyAspGlyAla AlaLeuGlnGIuIjysLeuCysAlaThrTyrLysLeuCysHisProGIuGluLeuVaiLeuLeuGIyHisSerLeu GlyIIe?roTrpAlaProLeuSerSerCys ProSerGinAlaLeuGInLeuAiaGiyCysLeuSerGlnLeuHi s 45 SerG-lyLeuPheLeuTyrGInGIyLeuLeuGlnAlaLeuGluGIylleSerProGluLeuGlyProThrLeuAsp ThrLeuGinLauAspValAlaAspPheALaThrThr I ieTrpGlnGlnMecGluGluLeuGlyMetiAlaProAla LeuG 1 nPr oT hrG i nG 1 yA 1 aMe tPiroAla? he A laSerAiaPheGl nAr gArgAl aG lyG 1 y Va 1 LeuVa 1A _! a SerHisLeuGlnSerPheLeuGiuValSerTyrArgValLeuArgHisLeuAlaGInPro SEQ ID NO :735 50 pMON3 57 5 9. pep

AlaSerLysMecGlnGlyLeuLeuGluArgValAsnThrGiuIleHisPhe'/alThrLysCysAlaPheGinP:：··:〕 ?roProSerCysLeuArgPheVaiGlnThrAsnlieSerArgLeuLeuGlnGluThrSerGiuGlnLeuValAla LeuLysProTrpIieThrArgGlnAsnPheSerArgCysLeuGIuLeuGlnCysGlr.ProAspSerSerThrLeu 55 G i yG 1 yG 1 y S e r G1 y G1 y G1 y S e r G i y G1 v G1 y S e r G1 y G1 y GI y T h r G1 n.-* s p C y s S e r ? h e G1 nH i s S e r ? r o

IleSerSerAspPheAlaValLysIleArgGluLeaSerAspTyrLeuLeuGlrLAopTyrProValThrVaiAia S e r As aLeuG I nAs pG I uG 1 uLeuCy sG 1 yG Iy LeuT r pAr g Leu Va ILe1^ IaG 1 ri^.r gTrpMe tG i uArg Leu LysThrVal AiaGiyTyrVaiGluGlyGlyGlyGlySer ProGlyGiu?roSerG.ly?roI leSerThr I leAsn ProSer ProProSerLysGluSerHisLysSex'ProAsnMetAlaThrProLeuGlyProAlaSerSerLeuPro 60 GlnSerPheLeuLeuLysCysLeuGluGlnValArgLysIleGlnGlyAspGLyAlaAlaLeuGlnGluLysLeu CysAlaThrTyrLysLeuCysHis ProGluGluLeuVaiLeuLeuGlyKisSerLeuGlylleProTrpAlaPro LeuSerSerCys ProSerGInAlaLeuGlnLeuAlaGiyCysLeuSerGJ.nLeuHisSerGiyLeuPheLeuTyr GlnGlyLeuLeuGInAlaLeuGluGlyIleSerProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspVaI A1aAs ρ P heA i aT h rThr11eT rpG1nG i nMe CG L uG1uLeuG LyMe tΛ1a ? r oA1a LeuG L π P r oTh rG1nGly 65 AiaMet: ProAlaPheAlaSerAlaPheGlriArgArgAlaGlyGlyVa iLeuValAlaSerHisLeuGlnSer ?he

LeuGiuVaiSerTyrArgValLeuArgHisLeuAiaGlnPro SEQ ID MO :736 ΌΜΟΜ3 57 6 0. pep 70 AlaSerL'/sMe tGlnGlyLeuLeuGluArgVaiAsnThrG Lu 二 Phe.'/alThrLysCysAlaPheGlnPiro

Pro ProSerCysLeuArgPheVa iGirrrhrAsnl leSerArgLeuLeuGirvGluThrSerG!uGlnLeuVal Aid LeuLysProTrpI LeThrAirgGlaAsnPheSeirArgCysLeuGLuLeuGinCysG LriProAspSerSerThrLeu GI yG 1 yG 1yS erG1yG1yG1yS e rG1yG1yG1vS e rG1yG1yG1yTh rG1 oAs pCys SerPheGlnHisSerPro IleSerSerAspPheAlaVa LLvrsIleArgGluLeuSerAspTyrLeuLeuGinAspTyrProValThrVaiAia 75 SerAsnLeuGlrJXspGluG LuLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGirLArgTrpMetGluArgLeu -256-

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LysThrValAlaGlyTyrValGluGlyGlyGlyGlySerProGIyGluProSerGlyProIleSerThrlleAsn ProSeirPrQPiroSerIjysGiuSerHisLysSerProAsrLHetAlaThirProIjeuGlyProAlaSerSerlieuPro GlnSerPheLeuLeuLysCysLeuGluGlnValArgLysIleGlnGlyAspGlyAlaAlaLeuGlaGluLysLeu CysAlaThrTyrLysLeuCysHis ProGluGluLeuValLeuLeuGlyHisSerLeuGlylleProTrpAlaPro 5 LeuSerSerCysProSerGlnAlaLeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPheLeu'Tyr GlnGlyLeuLeuGlnAlaLeuGiuGlylleSerPrQGluLeuGlyProThrljeuAspThrLeuGlnljeuAspVa 丄

AlaMetProAlaPheAlaSerAlaPheGlnArgArgAlaGlyGlyValLeuValAlaSerHisLeuGlnSerPhe LeuGluValSerTyrArgValLeuArgHisLeuAlaGlnPro SEQ ID N〇：737 10 pMON35761.pep

AlaLeuCysGlyGlyLeuTrpArgLeuValLeijAIaGlnArgTrpMetGluArgLeuLysThrValAlaGlySer LysMetGlnGlyLeuXjeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProPro 15 SerCysLeuArgPheValGlnThrAsnlleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLys ProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysArgPr〇i\spSerSerThrLeuGlyGly GlySerGlyGlyGlySerGlyGlyGlySerGlyGIyGlySerGlyGlyGlySerGlyThrGlnAspCysSerPhe GlnHisSerPr◦工leSerSerAsnPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrPro ValThrValAlaSerAsnLeuGlnAspGluGluTyrVaiGluGlyGlyGlyGlySerProGlyGluProSerGly 20 ProIlePheThrIleAsnProSerProProSerLysGluSerHisLysSerProAsnMetAlaThrProLeuGly

ProAlaSerSerLeuProGlnSerPheLeuLeuLysCysLeuGluGlnValArgLysIleGlnGlyAspGlyAla AlaLeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHis ProGluGluLeuValLeuLeuGlyHisSerLeu GlylleProTrpAlaProLeuSerSerCysProSerGlnAlaLeuGlnLeuAlaGlyCysLeuSerGlnLeuHis SerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlylleSerProGluLeuGlyProThrLeuAs? 25 ThrLeuGlnLeuAspValAlaAspPheAlaThrThr IleTrpGlnGlnMet:GluGluLeuGlyMet:AlaProAla LeuGlnProThrGlnGlyAlaMetProAlaPheAlaSerAlaPheGinArgArgAlaGlyGlyValLeuValAia SerHisLeuGlnSerPheLeuGluValSerTyrArgValLeuArgHisLeuAIaGlnPro SEQ ID NO :738 pMOM35762.όθό 30 ~

AlaGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGly SerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleKisPheValThrLysCysAlaPheGlnProPro ProSerCysLeuArgPheValGlnThrAsnlleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeu 供 LysProTrpIieThrAx'gGinAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGly 35 GlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyThrGlnAspCysSer PheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyr ProValThrValAlaSerAsnLeuGlnAspGluTyrValGluGlyGlyGlyGiySerProGlyGluProSerGiy ProIleSerThrlleAsnProSearProProSerLysGluSeirHisLysSerProAsnMetAlaThrProLeLiGly ProAlaSerSerLeuProGlnSerPheLeuLeuLysCysLeuGluGlnValArgLysIleGlnGlyAspGlyAla 40 AlaLeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHisProGluGluLeuValLeuLeuGlyHisSerLeu GlylleProTrpAlaProLeuSerSerCysProSerGlnAlaLeuGlnLeuAlaGlyCysLeuSerGlnLeuHis SerGlyLeuPheLeuTyrGInGlyLeuLeuGlnAlaLeuGluGlyIleSerProGluLeuGlyProThrLeLL*\3p ThrLeuGlnLeuAspValAlaAspPheAlaThrThrlleTrpGlnGlnMetGluGluLeuGlyMetAlaProAla LeuG 丄 nProThirGlnGlyAlaMetPiroAiaPheAlaSerAlaPheGlnArgArgAlaGlyGlyValLieiiValAia 45 SerHisLeuGlnSerPheLeuGluValSerTyrArgValLeuArgHisLeuAlaGlnPro SEQ 工D NO :739 pMON3 5763. pep

AlaGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAla 50 GlySerLysMetGlnGlyLeuLeuGluArg'/alAsnThrGluIleHisPheValThrLysCysAiaPheGlnPro ProProSerCysLeuArg?heValGlnThrAsriIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValALa LeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLGU GlyGlyGlySerGlyGlyGlvSerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyThrGlriAspCys Ser?heGlnHisSer?roIleSerSerAspPheAlaVaiLys工leArgGluLeuSerAspTyrLeuLeuGlnAsp 55 TyrProValThrValAlaSerAsnLeuGlnAspTyrValGluGlyGlyGlyGiySerProGlyGluProSerGiy ProIleSerThrIleAsnProSerProProSerLysGluSerHisLysSerProAsnMetAlaThrProLeuGiy ProAlaSerSerLeuProGlnSerPheLeuLeuLysCysLeiiGluGlnValArg乙ysIleGlnGlyAspGlyAla AlaLeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHisProGluGluLeuValLeuLeuGlyHisSerLou GlylleProTrpAlaProLeuSerSerCysProSerGlnAlaLeuGlnLeuAlaGlyCysLeuSerGlnLeuHis 60 SerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlylleSerProGluLeuGlyProThrLeuAsp

LeuGlnProThrGlnGlyAlaMetProAlaPheAlaSerAlaPheGlnArgArgAlaGlyGlyValLeuValAIa SerHisLeuGlnSerPheLeuGluValSerTyrArgValLeuArgHisLeuAlaGinPro SEQ ID NO :740 65 pMON3 57 64. pep

AlaGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThr

ValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPhe

GinProProPr'oSerCysLeuArgPheValGinThrAsriIleSerArgLeuIjeuGinGluThrSerGluGinLiei: 70 ValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSer

ThrLeuGlyGlyGlySerGiyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyThrGln AspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLfju GlnAspTyrProValThrValAlaSerAsnLeuTyrValGluGlyGlyGlyGlySerProGlyGluProSerGly PiroIleSerThrlleAsnPiroSer'PircProSerLjysGluSerHisIjysSerProAsrLMetAlaThirPiroIjeuGly 75 ProAlaSerSerLeuProGlnSerPheLeuLeuLysCysLeuGluGlnValArgLysIleGlnGlyAspGlyAla -257·

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AlaLeuGlnGluLysLeuCysAiaThrTyrLysLeuCysHisProGluGluLeuVaileuLeuGlyHisSerLeu GiylleProTrpAiaProLeuSerSerCysProSerGlnAlaLeuGlnLeuAlaGlyCysLeuSerGInLeuHis SerGlyLeuPheLeuTyrGinGlyLeuLeuGlnAiaLeuGluGlylleSer?rcGluLeuGlyProThrLeuAsp 一 ThrLeuGInLeuAspValAiaAspPheAlaThrThrlleTrpGlnGlnMecGiuGlu^euGlyMetAlaProAla 5 LeuGlnProThrGlnGlyAlaMetPrcAlaPheAlaSerAlaPheGlnArgArgAlaGlyGlyValLeuVaiAla SerHisLeuGlnSerPheLeuGiuValSerTyrArgValLeuArgHisLeuAIaGlnPro SEQ ID MO :7 41 PMON35765.pep

AsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySer GlyGlyGiySerGlyGIyGlyThrGinAspCysSerPheGlnHisSerProI leSerSerAsoPheAlavalLys IleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeu CysGlyGlyLeuTrpArgLeuValLeuAiaGlnArgTrpMetGIuArgLeuLysThrValAlaGlySerLvsMet: 15 GlnGiyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCys LeuArgPheValGlnTyrValGluGlyGlyGiyGlySer?roGlyGiu?roSerGly?roIleSerThrIleAsn ProSerProProSerLysGluSerHisLysSerProAsnMetAiaThrProLeuGlyProAiaSerSerLeuPro GlnSerPheLeuLeuLysCysLeuGiuGlnValArgLysIleGlnGlyAspGlyAlaAlaLeuGlnGluLysLeu CysAlaThrTyrLysLeuCysHisProGluGluLeuValLeuLeuGlyHisSerLeuGlylleProTrpAlaPro 20 LeuSerSerCysProSerGlnAlaLeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyr GlnGli/LeuLeuGlnAlaLeuGIuGlylleSerProGluLeuGlyProThrLeuAspThrLeuGinLeuAspVal AlaAspPheAlaThrThrlleTrpGlnGlnMetGIuGluLeuGlyMecAlaPrcAiaLeuGlnProThrGlnGly AiaWetProAlaPheAlaSerAlaPheGlaArgArgAlaGlyGlyValLeuVaiAiaSerHisLeuGlaSerPhe LeuGluValSerTyrArgVaiLeuArgHisLeuAlaGlnPro SEQ ID Ni〇：742 25 PMON3 57 5 5 . pep/'cMON3 2190 . pep/pMON40001. pep ,

AlaAspGluGluLeuCysGlyGlvLeuTrpArgLeuValLeuAlaGinArgTrpMetGIuArgLeuLysThrVai AlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIlsHisPheValThrLysCysAlaPheGln 30 ProProProSerCysLeuArgPheValGlnThrAsnlleSerArgLeuLeuGlnGluThrSerGluGlnLeuVal MaLeuLysProTrpIle.ThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThr L euG 1 1 yG 1 y S e r G1 yG 1 yG i yS e r G1 yG 1 yG lyS erG ί yG 1 yG 1 yS e rG 1 yG i yG 1 yS e rG 1，ThrG InAs p

CysSerPheGinHisSerProIleSerSerAspPheAlaValLysIleArgGiuLeuSerAspTyrLeuLeuGln ” AspTyrProValThrValAlaSerAsnLeuGInTyrValGluGlyGlyGlvGlySerProGIyGIyGlySerGiy 35 GiyGlySerAsnMetAlaThrProLeuGlyProAiaSerSerLeuPrcGlnSerPheLeuLeuLvsSerLeuGlu GlnValArgLysIIeGlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHisPro GluGluLeuValLeuLeuGlyHisSerLeuGlylleProl'rpAiaProLeuSerSerCysProSerGlnAlaLeu GlnLe'jAiaGiyCysLeuSerGinLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeuGluGly IleSerProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAlaThrThrIleTrpGln 40 GlnMetGluGluLeuGlyMetAlaProAlaLeuGlnProThrGlnGlyAlaMetProAiaPheAlaSerAlaPhe G1 nAr g Ar g A1 aG 1 yG 1 y V a 1L e u Va 1A laSerKis LeuG I n S e r ? he L e uG i uVa 1S e rTy r Ar g Va i Leu Ar g HisLeuAlaGlnPro SEQ ID NO :743 PMON35763.oec 45 *

AlaGlpxAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGiuArgLeuLysThr ValAlaGlySerLysMetGinGlyLeuLeuGluArgValAsnThrGluIleHisPheVaiThrLysCysAlaPhe GlnProProProSerCysLeuArgPheValGlnThrAsnlleSerArgLeuLeuGinGluThrSerGiuGlnLeu ValAlaLeuLy3?roTrpIleThrArgGrrLAsn?heSerArgCysLeuGiuLeuGlnCysGlr.?roAspSerSer 50 ThrLeuGIyGiyGlySerGlyGlyGiySerGiyGlyGlySerGiyGIyGlySerGiyGlyGiySerGIyThrGln AspCysSerPheGlnHisSerProIleSerSerAspSerAlaVaILys11eArgG1uL eu S erAs p'Tyr LeuL eu G1 nAs pT y r ? r o Va 1T h r Va 1A1 a S e r A s a L e uTy r Va 1G1 uG 1 y G1 y G1 y G1 y S e r ? r o G1 yG 1 u ? r o 3 e r GI y Prol ieSerThr IleAsnProSerProProSerLysGluSerHisLysSer ProAsnKecAlaThr ProLeuGly ProAlaSejrSerrjeuPrcGlnSerPheLeuLeuIjysCysLeuGluGirLValAr.gljys 工]_eGlr‘GlyAspGl，/AJLa 55 AI aL e uG i nG 1 u L y s L e uC y s AI aT h rTy r Ly s L euC y s H i s P r oG I uG 1 u L e u va 1L e u L e uG 1 y H i s S e r L e u

Glyl iePiroTirpAlaPiroLeuSerSeirCysPirQSeirGlnAlaLeuGlnLeuAlaGlyCysLeuSerGlriLeuHis SerGlyLeuPheLeuTyrGlnGlyLeuLeuGIaAiaLeuGiLiGlylleSerProGluLeuGlyProThrLeuAsp Thr L e uG 1 n L e u As p Va 1A1 a As ρ P h e A1 aT h r T h r 11 eT r pG 1 nG 1 n^Me t G i uG i u Le uG 1 '/Me cAiaProAia L e uG 1 η P r oT h r G1 nG 1 y A1 aMe t ? r o A1 a ? h e A1 a S er A1 a P heG 1 rJ\rg Ar g A1 aG 1 yG i y va i L e u Va IΛ i a 60 SerHisLeuGinSerPheLeuGluValSerTyrArgValLeuArgHisLeuAiaGlnPro SEQ ID MO :7 44 pMON3S770.pep — AlaLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySer 65 LysMe tGinGiyLeuLeuGiuArgVaiAsnThrGluIleHis PheV.alThrLysTyrAlaPheGlnProProPiro

SerCysLeuArgPheVaiGlnThrAsnlleSerArgLeuLeuGlnGluThrSerGiuGlnLeuValAiaLeuLvs ProTrpIleThrArgGinAsnPheSerArgCysLeuGluLeuGlnCysArgProAspSerSerThrLeuGlyGly GlySerG lyG lvGlySerGivrG lyGlySerGlyGlyGlySerGlyThrGlpJ^spCysSer PheGInHisSer Pro IleSerSerAspPheAlaValLyslieArgGluLeuSerAspTyrLeuLeuGlaAspTyrPrcVaiThrValAia 70 S e r As n L e uG 1 n As pG I uG 1 uT y r V a 1G1 uG i y G1 yG i y G1 y S e r ? r c-G 1 yG 1 u ? r o S e r G1 y ? r ο 11 e S e r T h r 工 oSerProProSerLysGiuSerHisLysSerProAsnMetAlaThrProLeuGly?roAlaSerSeir

LeuPrcGinSerPheLeuLeuLysCys LeuGluGlnValArgLysIleGlaGlyAspGlyAiaAlaLeuGlaGlu LysLeuCysAlaThrTyrLysLeuCysHis PrcGluGluLeuValLeuLeuGlyHisSerLeuOiylleProTrp AlaProLeuSerSerCys ProSerG In-AlaLeuGlnLeuAlaG lyCysLeuSerGlnLeuHisS-erGlyLeuPhe 7 5 LeuTy rG LnG LyLeuLeuGlaAiaLeuG luG ly I leSerPrcGluLeuGly ProThrLeuAspTiirLeuGlnLeu - 258 -

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AspValAlaAspPheAiaThrThrl 1βΤι:ρ01η〇1ηΜθί：01ιισ：ΙαΙ<θυι〇1γΜβί:ΑΐΑ?Γ3ΑΐΑΐ^θΐ·ΐ01ηΡι·〇τ4}： GlnGlyAlaMetProAlaPheAlaSerAlaPheGlnArgArgAlaGlyGlyValLeuValAlaSerHisLeuGln SerPheLeuGluValSerTyrArgValLeuArgHisLeuAlaGlnPro SEQ ID NO :745 5 pM〇N35772.pep AlaSerLysMenGlnGlyLeuLeuGluArg'/alAsnThrGliil leHisPheValThrLysCysAlaPheGlnPro ProProSerCysLeuArgPhe'/aiGlnThrAsri 工 leSerArgLeuLeuGlnGluThrSerGluGlnLeuValAla LeuLysProTrpI leThrArgGlnAsnPhePheArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeu 10 GlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGIyGlyGlyThrGlnAspCysSerPheGlnHisSerPro IleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlaAspTyrProValThrValAla SerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeu LysThrValAiaGlyTyrValGluGlyGlyGlyGlySer ProGlyGluProSerGlyProlisSerThrIleAsn ProSarProProSerLvsGluSerHisLysSerProAsnMetAlaThrProLeuGlyProAlaSerSerLeuPro 15 G1 nSe r PheLeuLeuLy sCys LeuGluGlnVa iAr gLys I leGlnG lyAspGlyAiaAl aLeuGlnGluLys Leu CysAlaThrTyrLysLeuCysHisProGiuGluLeuValLeuLeuGlyHisSerLeuGlylleProTrpAlaPro LeuSerSerCysProSerGlnAlaLeuGlnLeuAiaGlyCysLeuSerGlaLeuHisSerGlyLeuPheLeuTyr GlaGlyLeuLeuGlrJ\laLeuGIuGlyIleSer?roGiuLeuGlyProThrLeuAspThrLeuGlnLeuAspVaI AlaAspPheAlaThrThrIleTrpGInGinMecGluGiuLeuGlyMeCAlaProAlaLeuGlnProThrGlnGly 20 AlaJMetProAlaPheAIaSerAlaPheGlPLArgArgAlaGlyGlyValLeuValAlaSerHisLeuGinSerPhe LeuGluValSerTyrArgValLeuArgHisLeuAlaGinPro SEQ ID N〇：746 PMON35773.pep AlaGlrJ\spGluGluLeuCysGlyGlyLeuTrpArgLeuVaiLeuAlaGlnArgTrpMet:GluArgLeuLysThr ValAlaGlySerLysMetGlnGlyLeuLeuGluArgyalAsnThrGluIleHisPheValThrLysCysAiaPhe GlnProProProSerCysLeuArgPheValGlnThrAsnlleSerArgLeuLeuGlnGluThrSerGiuGlnLeu VaiAlaLeuLysProTrpIieThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSer ThrLeuGlyGiyGlySerGiyGiyGlvSerGlyGlyGlySerGlyGlyGlySerGlyGl'/GlySerGlyGlyGly SerGlyGlyGiySerGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLiys lie ArgGiuLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuTyrValGluGlyGlyGly GlySerProGlyGluProSerGlyProIleSer.ThrlleAsnProSerProProSerLysGluSerHisLysSer ProAsnMecAlaThrProLeuGly?roAlaSerSerLeu?roGlnSer?heLeuLeuLysCysLeuGluGlnVal ArgLysI leGlnGlyAspGlyAlaAiaLeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHisProGluGlu LeuValLeuLeuGlyHisSe;rLeuGlyIleProT::pAlaP::oLeuSei:SerCysPi:oSerGlnAlaLeuGlnLeu AlaGlyCysLeuSerGlnLeuKisSerGlyLsuPheLeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlylleSer GluGluLeuGlyMe tAlaProAlaLeuGlnProThrGlnGlyAlaMeCProAlaPheAiaSerAlaPheGlaArg ArgAlaGlyGlyValLeuValAlaSerHisLeLiGinSerPheLeuGluValSerTyrArgVaiLeuArgHisLeu AlaGlnPro SHQ ID N〇：747 · pMOM 35777.pep AlaGlrL^spGIuGluLeuCysGlyGlyLeuTrpArgLeuVaiLeuAlaGlnArgTrpMetiGluArgLeuLysThr ValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluI LeHisPheValThrLysCysAlaPhe GlnProProProSerCysLeuArgPheValGlnThrAsnlleSerArgLeuLeuGlnGluThrSerGluGlnLeu ValAlaLeuLysProTrpIleThrArgGlrLAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSer ThrLeuPro ProProTrpSerProArgProLeuGlyAlaThrAlaPrcThrThrGlnAspCysSerPheGlnHis SerPrcIieSerSerAspPheAlaValLtsIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThr ValAlaSerAsnLeuTyrValGluGlyGlyGlyGlySerPrcGiyGluProSerGlyProIleSerThrlleAsn ProSerProProSerLysGIuSerHisLysSerProAsnMecAlaThrProLeuGlyProAlaSerSerLeuPro GlnSerPheLeuLeuLysCysLeuGiuGlaValArgLysIleGlnGlyAspGlyAlaAlaLeuGlnGluLysLeu CysAlaThrTyr LysLeuCysHisProGluG luLeuVaiLeuLeuGIyHisSerLeuGiylleProTrpAlaPro LeuSerSerCys ProSerGlnAlaLeuGInLeuAlaGlyCysLeuSerGInLeuHisSerGlyLeuPheLeuTyr GlnGlyLeuLeuGInAlaLeuGluGlyIleSerPrcGluLeuGlyProThrLeuAspThrLeuGinLeuAspVaI AlaAsp?heAiaThr_rhrIleTrpGlnGlruMecG AlaMetProAlaPheAlaSerAlaPheGlr^rgArgAlaGlyGlyVaiLeuValAlaSerHisLeuGlnSer Phe LeuGluValSerTyrP-.rgVaiLeuArgHisLeuAlaGinPro SEQ ID NO :7 43 60 pMOM3 5 7 7 3. pep AlaGinAspGiuGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGInArgTrpMetGluArgLeuLysThr ValAiaGlySerLysMetGlnGiyLeuLeuGluArgValAsnThrGiuIleHisPhe'/alThrLysCysAlaPhe GlnProProProSerCysLeuArgPneVaiGlnThrAsnlLeSerArgLeuLeuGlnGluThrSerGluGlnLeu ValAlaLeuLys ProTrpI ieThrArgGlnAsnPheSerArgCysLeuGluLeuGinCysGlnProAspSerSer ThrLeuProPro ProTrpSer ProArgProLeuGlyAlaThrAlaProThrAlaGlyGlnProProLeuThrGln AspCysSer PheGinHisSerProIleSerSerAspPheAIaValLys I IeArgGluLeuSerAspTyrLeuLeu GlrLAspTyrProValThrVaiAlaSerAsnLeuTyrVaiGluGlyGlyGlyGlySerProGlyGluProSerGly Pr〇工丄eSerThr 11<ΞΐΑ3ηΡ::ο3θΓΡΐΓ〇Ρι·〇3€ίΐΓΐ^/5ΰ1<α5βι:Ηί3ΐ^/；55θ：ΓΡΐ··οΑ3ηΜΘΐ:ΑΐΑΤΐιι:ΡΓ〇]1(θΐα0·1'/ ProAlaSer Ser LeuProG laSerPheLeuLeuLysCysLeuGluGlnVaiArgLys I leGlnGlyAspGlyAla AlaLeuG 1 nG i li Lys LeuCy sA 1 aThrTy r Ly s LeuCy sH i s ProGiuGluLeuVa iLeuLeuG I yHi.sSer Leu GlylleProTrpAlaProLeuSerSerCys ProSerGlnAlaLeuGlnLeuAlaGlyCysLeuSerGlnLeuHis SerG I'/LeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlyILeSerProGiuLeuGlyProThrLeuAsp ThrLeuGinLeuAspValPvlaAspPheAlaThirThrlieTrpGlnGiruMecGluGluLeuGlyMetAlaPzroAla 25

30 35 40 45 50

55

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LeuGlnProThrGinGlyAlaMet:Pi:oAlaPheAlaLSerAlaPheGlnA:rgArgAlaGlyGly\/aL JLLeuValAla SerHisLeuGlnSerPheLeuGluValSerTyrAxgValLeuArgHisLeuAlaGlnPro SEQ ID MO :74 9 PMCN35779.pep 5

AlaAscGiuGluLeuCysGlyGIyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrVal AlaGlySerLysMecGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAldPheGln ProPrcProSerCysLeuArgPheValGlnThrAsnlleSerArgLeuLeuGlnGluThrSerGluGlnLeuVal AlaLeuLys ProTrpIleThrArgGlnAsnPheSerArgCysLeuGiuLeuGiaCysGlnProAspSerSerThr 10 LeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGiyGlyGlySerGlyGlyGlySer GlyGlyGIySerGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArg GluLeuSerAspTyrLeuLeuGlrLA.spTyrProValThrValAlaSerAsnLeuGinTvrValGluGlyGlyGly

ProAsrJ^etAlaThr ProLeuGlyProAlaSerSerLeuProGlr.SerPheLeuLeuLysCysLeuGluGlnVal 15 ArgLysIleGlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHisProGluGlu LeuVaiLeuLeuGlyHisSerLeuGlyllsProTrpAlaProLeuSerSerCysProSerGlnAlaLeuGlnLeu AlaGlyCysLeuSerGinLeuHisSerGlyLeuPheLsuTyrGlnGlyLeuLeuGlnAlaLeuGluGlylleSer ProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAlaThrThrlleTrpGlnGlnMet: GluGIuLeuGlyMetAlaProAlaLeuGlnProThrGlrxGlyAlaMetProAlaPheAlaSerAlaPheGlnArg 20 ArgAlaGlyGlyValLeuValAlaSerHisLeuGlnSerPhsLeuGluValSerTyrArgValLeuArgHisLeu AlaGlnPro SEQ ID ：750 pMON3 5 78 0. pep 25 AlaAspGluGiuLeuCysGlyGlyLeuTirpArgLeuValLeuAlaGlnArgTrpMetGiuArgProIjysThrVal AlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGlu工leHisPheValThrLysCysAiaPheGln ProProProSerCysLeuArgPheValGlnThrAsnlleSerArgLeuLeuGlnGluThrSerGluGlnLeuVai AlaLeuLysProTrpIleThrArgGinAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThr LeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySer 30 GlyGlyGlySerGlyThrGlnAspCysSer*PheGlnHisSer?roIleSerSerAspPheAlaValLysIleArg GluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnTyrValGluGlyGlyGly GlySerPrcGlyGluProSerGlyProIIeSerThrlleAsnProSerProProSerLysGluSerHisLysSer ProAsnMetAlaThrProLeuGlyProAiaSerSerLeuProGlnSerPheLeuLeuLysCysLeuGluGlnVal ArgLysIIeGinGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHisProGluGlu 35 LeuValLeuLeuGlyHisSerLeuGlyIXeProTrpAlaProLeuSerSerCysProSerGlnAlaLeuGlnLeu

AlaGlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlylleSer ProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAlaThrThrlleTrpGlnGlnMet GluGIuLeuGlyMetAlaProAlaLeuGlnProThrGinGlyAlaMetProAlaPheAlaSerAlaPheGlnArg ArgAlaGlyGlyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSerTyrArgValLeuArgHisLeu 40 AlaGlnPro SEQ ID NO :751 PMON35782.pep

AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeu^.IaGlnArgTrpMetGluArgLeuLysThrVal 45 AlaGiySerLysMetGinGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLiysCysAlaPheGin ProProProSerCysLeuArgPheValGlnThrAsnlleSerArgLeuLeuGlnGluThrSerGluGlnLeuVal AlaLeuLys ProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThr LeuPro?roProTrpSer?roArgProLeuGlyAiaThrAlaProThrAiaGlyGlnProProLeuThrGlnAsp CysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGin 50 AspTyrProValThrValAlaSerAsnLeuGlnTyrValGiuGiyGlyGlyGlyiThrPrcGlyGluProSerGl·/ ProIleSerThrl leAsnProSerProProSerljysGluSerHisLysSer P::oAsn>!etAlaThrP::oLeuGl：/ ProAiaSerSerLeuProGlnSerPheLeuLeuLysCysLeuGluGlnValArgLysIieGlnGlyAspGlyAia AlaLeuGInGluLysLeuCysAiaThrTyrLysLeuCysHisProGluGluLeuValLeuLeuGlyHisSerLeu GlylleProTrpAlaProLeuSerSerCysProSerGlnAlaLeuGinLeuAlaGlyCysLeuSerGlnLeuHis 55 SerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAiaLeuGluGlyIleSerProGluLeuGiyProThrLeuAsp ThrLeuGlnLeuAspVaiAlaAspPheAlaThrThrllsTrpGlnGlnHetGIuGluLeuGlyMetAlaProAla LeuGInProThrCinGlyAlaMetProAlaPheAlaSerAlaPheGlnArgArgAlaGlyGlyValLeuValAla SerHisLeuGiaSerPheLeuGluValSerTyrArgValLeuArgHisLeuAlaGlnPro SEQ ID NO :7 52 60 〇MOM3990 8. pep

AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlp^rgTrpMetGluArgLeuLysThrVai

ProProProSerCysLeuArgPheValGlnThrAsnlieSerArgLeuLeuGlnGluThrSerGluGlnLeuVal 65 AlaLeuLys ProTrpIleThrArgGlr^snPheSerArgCysLeuGluLeuGlnCysGlnProValGluThrVal PheHisArgValSerGlnAspGlyLeuAspLeuLeuThrSerThrGlnAspCysSerPheGlnHisSerPro lie SerSerAsp?heAlaValLys XleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProVaXThrValAlaSer

LeuGi/ProAlaSerSerLeuPrcGlnSerPheLeuLeuLysSerLeuGluGlnValArgLysIleGlnGlyAsp 70 GlyAlaAlaLeuGinGluLysLeuCysAlaThrAsnLysLeuCysHis ProGluGluLeuVa XLeuLeuGlyHis

SerLeuGlyIleProTrpAlaProLeuSerSerCysProSerGinAlaLeuGlnLeuAlaGlyCysLeuSerGin LeuHisSerGlyLeuPheLeuTyrGlaGlyLeuLeuGlnAlaLeuGIuGlyIleSerProGluLeuGlyProThr LeuAspThrLeuGlnLeuAspValAlaAspPheAlaThrThrIleTrpGlnGlnJMetGluGluLeuGlyMecAla ProAlaLe^GinProThrGlnGlyAlaMecProAlaPheAlaSerAlaPheGlnArgArgAlaGlyGIyValLeu 260-

O:\92\92747.DOC 200413407

ValAlaSer'HisLeuGlnSerPheLeuGluValSerTyrArgValLeuArgHisLeuAlaGlnPro SEQ ID NO：753 5 pMON3227 5. pep

AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrVal AlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGln ProProProSerCysLeuArgPheValGlnThrAsnlleSerArgLeuLeuGlnGluThrSerGluGlnLeuVal 10 AlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluI>euGlnCysGlnPr〇AspSerSerThr LeuTyrValGluGl'/GlyGlyGlySerProGlyGluProSerGlyProIleSerTfirlleAsnProSerProPro SerLysGiuSerHisLysSerProAsnMetAlaThrProLeuGlyProAlaSerSerLeuProGlnSerPheLeu

LysLeuCysHisProGluGluLeuValLeuLeuGlyHisSerLeuGlylleProTrpAlaProLeuSerSerCys 15 ProSerGlnAlaLeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeu GlnAlaLeuGluGlylleSerPjroGluLeuGl'/ProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAla ThrThrlleTrpGinGinMetGluGiuLeuGlyMetAlaProAlaLeuGinProThrGinGlyAlaMetPrQAla PheAlaSerAlaPheGlnArgArgAlaGlyGlyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSer TyrArgValLeuArgHisLeuAlaGlnProTyrValGluGlyGlyGlyGlySerProGlyGluProSerGiyPro 20 IleSerThirlleAsnProSerProPiroSeirLysGluSerHisLysSerPrcAsnMetAlaThrGlnAspCysSei: PheGlnHisSerProIleSerSerAspPheAla'/alLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyr ProValThrValAlaSerAsnLeuGln SEQ 工D NO :754 *" - pMON35781.pep

25

AlaThrGlnAspCysSerPheGlnHisSerProIieSerSerAspPheAlaValliysIleArgGluLeuSerAsp TyrLeuLeuGlnAspTyrProValThrValAiaSerAsnLeuGlriGluProLysSerProAspThrHisThrSer ProProSerProThrProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeuLysSerLeuGluGlnVal , ArgLys工leGlnGlyAspGl於laAlaLeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHisProGluGlu 30 LeuValLeuLeuGlyHisSerLeuGlylleProTrpAlaProLeuSerSerCysProSerGlnAlaLeuGlnLeu AlaGlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlylleSer ProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAlaThrThrlleTrpGlnGlnMet GluGluLeuGlyMetAlaProAlaLeuGlnProThrGlnGlyAlaMet?roAla?heAlaSerAla?heGlnArg i _ ArgAlaGlyGlyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSerTyrArgValLeuArgHisLeu 35 AlaGlnProSerAlaGluProLysSerProAspThrHisThrSerProProSerProGlySerAsnLeuGlnAsp

GluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGly SerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProPro ProSerCysLeuArgPheValGlnThrAsnlleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeu LysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAsOSerSerThrLeu 40 SEQ 工D NQ:755 ‘ pM0N3 57 83. pep _ AlaThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAsp

LeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyTrpGlnGlyArg ValAsnThrGluIleHis PheValThrljysCysAiaPhePiroLysSerProAspThrHisThrSerProProSer ProGlyThrProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeuLysSerLeuGluGlnValArgLys 工leGlnGlyAspGlyAlaAlaLeuGlriGluLysLeuCysAlaTyrLysLeuCysHisProGluGluLeuValLeu 50 IjeuGlyHisSerLjeuGlylleProTrpAlaProLeuSerSerCysProSerGlnAlaLeuGlnLeuAlaGlyCys LeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlylleSerProGluLeu GlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAlaThrThrIieTrpGlnGlnMetGluGluLeu GlyMetAlaProAlaLeuGlnProThrGlnGlyAiaKetProAlaPheAlaSerAlaPheGlnArgArgAlaGly GlyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSerTyrArgValLeuArgHisLeuAlaGlnPro 55 SerAlaGl-uProLysSerProAspThrHisThrSerProProSerProGlyLysAlaPheGlnProProProSer CysL<auArgPheValGlnThrAsnIleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLys?ro TrpIleThrArgGinAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeu SEQ ID NO :756 60 pM〇N32276.pep s

AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrVal AlaGlySerLysMetGlrxGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysSerAlaPheGin 65 ProProProSerCysLeuArgPheValGlnThrAsnlleSerArgLeuLeuGlnGluThrSerGluGlnLeuVal AlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThr LeuGlyGlyGlySerGlyGlyGlySerGlyGlyGIySerGlyGlyGlySerGlyGlyGlySerGlyThrGlnAsp SerSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuC7ln AspTyrProValThrValAlaSerAsnLeuGlnTyrValGluGlyGlyGlyGlySerProGlyGlyGlySerGly 70 GlyGl'/SerAsnMetAla/ThrPiroLeuGlyPiroAlaSerSerLeuPrQGlnSeirPheLeuLeLiIjysSerljeuGiu GlnValArgljysIleGlnGlyAspGlyAlaAlaljeuGlnGluLysLeLiCysAlaThirAsnljysLeuCysHis Pro GluGluLeuValLeuLeuGlyHisSerLeuGlylleProTrpAlaProLeuSeirSerCysProSerGlnAlaLeu GlnLeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeuGluGl/ IleSerProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAlaThrThr 工 leTrpGln 75 Glni4etGluGluLeuGlvMetAlaProAlaLeuGlnProThrGlnGlvAlaKet:ProAlaPheAlaSerAlaPhe O:\92\92747.DOC -261 - 200413407 10 15 20 25 30 35

GlrL^rgArgAiaGIyGIyVaiLeuVaiAlaSerHisLeuGlnSerPhsLeuGiuVaiSerTvrArgVaiLeuAr^ HisLeuAiaGLaPro SZQ ID MO：757 ^ pMON3 2277. pep AlaThrProLeuGlyProAlaSerSerLeuProGInSerPheLeuLeuLysSerLeuGluGlnVaiArgLysIie GlnGlyAspGIyAlaAlaLeuGinGluLysLeuCysAlaThrTyrLysLeuCysHisProGluGluLeuValLeu LeuGlyHisSerLeuGIylieProTrpAlaProLeuSerSerCysProSerGInAlaLeuGlnLeLLAlaGlyCys LeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGinAlaLeuGluGiylieSerProGluLeu GlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAlaThrThrlleTrpGInGlnl^etGluGluLeu GlyMetAlaProAlaLeuGlnProThrGlnGlyAlaMeCProAlaPheAlaSerAlaPheGInArgArgAlaGiy GlyValLeuValAiaSerHisLeuGlnSerPheLeuGluValSerTyrArgValLeuArgHisLeuAlaGlnPro TyrVaiGluGlyGiyGIyGlySerProGlyGluProSerGlyProIleSerThrIIsAsnProSerProProSer LysGluSerHisLysSerProAsnMetAlaAspGluGluLeuCysGIyGlyLeuTrpArgLeuValLe^iaGin ArgTrpMetGluArgLeuLysThrValAlaGlySerLvsMetGlnGlyLeuLeuGluArgValAsnThrGIuIle HisPheValThrLysSerAlaPheGinProProPrQSerCysLeuAirgPheValGlrLThrAsnlleSerAxgLeu LeuGlnGluThrSerGIuGlnLeuVaiAlaLeuLysProTrpIieThrArgGlp^snPheSerArgCysLeuGlu LeuGlnCysGinProAspSerSerThrLeuGiyGlyGlySerGlyGlyGiySerGJLyGiyGiySerGlYGiyGly SerGlyGiyGlySerGlyThrGlnAspSerSerPheGlnHisSerProIleSerSerAspPheAlaV.alLysILe ArgGluLeuSerAspTyrLeuLeuGInAspTyrProValThrValAlaSerAsnLeuGIn SEQ 10 NO :753 pM〇N32278.pep AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGinArgTrpMe C.GluArgL.euLysThrVa.1 AlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHis PheVaiThrLysCysAlaPheGlr: ProProProSerSerLeuArgPheValGlnThrAsnlleSerArgLeuLeuGLnGluThrSerGiuGlnLeuVaL AlaLeuLysProTrpIleThrArgGlrLAsfiPheSerArgCysLeuGluLeuGlnSerGlnProAspSerSerThr LeuGlyGlyGlySerGlvGlyGlySerGlyGlyGlySerGlyGlyGlySerGIyGiyGlySerGlyThrGlrJ^sp CysSerPheGlnHisSerProIleSerSerAspPheAlaVairjysIleArgGluLeuSerAspTyrLeuLeuGlr· AspTyrProValThrValAlaSerAsnLeuGlnTyrValGluGlyGlyGiyGlySerProGlyGiyGlySerGly GlyGlySerAsnHetAlaThrProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeuLysSerLeuGiu GlnValArgLysIleGlnGlyAspGlyAlaAlaLeuGInGluLysLeuCysAIaThrAsnLysLeuCysHisPro GluGluLeuVaiLeuLeuGlyHisSerLeuGlylleProTrpAiaProLeuSerSerCysProSerGlnAlaLeu GlaLeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeuGluGiv IleSerProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAlaThrThrlleTrpGln GlaMetGluGluLeuGlyMetAlaProAlaLeuGlnProThrGlnGlvAlaMet?roAla?heAlaSerAlaPhe GlnArgArgAlaGlyGlyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSerTyrArgVaiLeuArg HisLeuAlaGlnPro SEQ ID N〇：759

40 45 50 55 60 65 70 pMON32279.pep AlaThrProLeuGlyProAiaSerSerLeuProGlnSerPheLeuLeuLysSerLeuGIuGlnValArgLysIle GlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHisProGiuGluLeuValLeu LeuGlyHisSerLeuGlylleProTrpAlaProLeuSerSerCvs ProSerGinAlaLeuGlaLeuAlaGlyCys LeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeuGiuGlylIeSerProGluLeu GlyProThrLeuAspThrLeuGJinLeuAspValAlaAspPheAlaThrThrl leTrpGinGlruMetGluGluLe1」 GlyMetAla?roAlaLeuGlaProThrGlnGlyAlaMetProAlaPheAlaSerAla?heGlr^\rgArgAlaGIy GlyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSerTvrArgVaiLeuArgHisLeuAlaGlnPro TyrValGluGIyGlyGlyGlySerProGlyGluProSerGlyProIIeSerThrlieAsnProSerProProSer LysGluSerHisLysSerProAsnKetAlaAspGluGluLeuCysGIyGlyLeuTrpArgLeuValLeuAlaGIn ArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGinGlyLeuLeuGI^jArgValAsnThrGluIle HisPheValThrLysCysAlaPheGlnProProProSerSerLeuArgPheValGInThrAsnlleSerArgLeu LeuGlnGluT'hrSerGluGlnLeuValAlaLeuL'/sProTrpI leThrAirgGlnAsr-PheSerArgCysLeuGLu LeuGlnSerGlnProAspSerSerThrLeuGlyGlyGlySerG lyGlyGlySerGlyGIyGlySerGlyGlyGIy SerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaVaiLysIle ArgGluLeuSerAspTyrLeuLeuGlaAspTyrProValThrValAlaSerAsnLeuGin SEQ ID N〇：760 PMON35790.pep AlaThrGlnAspSerSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAsp TyrLeuLeuGinAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeaTrpArg LeuValLeuAlaGlnArgTrpMecGluArgLeuLysThrValAlaGlySerLvsMecGlnGlyLeuLeuGluArg ValAsnThrGluIleHisPheVaIThrLysSerAlaPheGlnProProProSerCysLeuArgPheValGlnThr AsnlleSerArgLeuLeuGlnGluThrSerGluGlaLeuValAlaLeuLysProTrpIieThrArgGlnAsnPhe SerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuTyrValGluGlyGlyGlyGiySerProGiy GlyGlySerGlyGlyGlySerAsrLMeCAlaThrProLeuGlyProAIaSerSerLeuProGlaSerPheLeuLeu LysSerLeuGiuGInValArgLyslieGlnGlyAspGlyAlaAlaLeuGlnGluLvsLeuCysAlaThrAsnLys LeuCysHisProGluGluLeuValLeuLeuGlyHisSerLeuGlyIieProTrpAlaProLeuSerSerCysPro SerGioAiaLeuGlnLeuALaGlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGln AlaLeuGluGlyXleSerProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAiaThr Thl：IieTr·pGlnGlαMetGiuGluΓJeuGlyMet:AlaPl：oAlaIJeuG：Lp‘Pi：oThl：GlnG丄yAl·aMetP2：oAi£lPhe AlaSerAIaPheGLaArgArgAlaGlyGlyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSerTyr ArgValLeuArgHisLeuAlaGlnPro SEQ ID NO :7 61

75 pMON35791-pep O:\92\92747.DOC -262- 200413407 *八 / Υ — / ·» \ ^〇Q /

AlaThrGlnAspCysSerPheGlnHisSerPro IleSerSerAspPheAiaValLysIieArgGiuLeuSerAsp TyrLeuLeuGinAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArg LeuVaiLeuAlaGlnArgTrpMetGiuArgLeuLysThrValAlaGlySerLysMetGIaGiyLeuLeuGiuArg 5 ValAsnThrGluI leHis Phe'/alThrLysCysA 丄 aPheGlnPi:oProPr〇SerSerLeuArgPh‘e'/alGlnTinr

AsnlleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPhe SerArgCysLeuGLuLeuGlnSerGlnProAspSerSerThrLeuTyrValGluGlyGlyGlyGlySerProGly GlyGiySerGlyGlyGlySerAsnMeCAiaThrProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeu LysSerLeuGluGlnValArgLysIleGlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrAsnLys 10 LeuCysHis ProGluGluLeuValLeuLeuGl/HisSerLeuGlylleProTrpAiaProLeuSerSerCysPro SerGlnAlaLeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGln AiaLeuGiuGl'/I leSerProGluLeuGlyProThrLeuAspThrlieuGlnLeuAspValAlaAspPheMaThr ThrIleTrpGlnGlnMetGluGluLeuGlyMetiAlaProAlaLeuGlnProThrGlnGlyAlaMetProAlaPhe AlaSerAlaPheGlnArgArgAlaGlyGiyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSerTyr 15 ArgValLeuArgHisLeuAlaGinPro SEQ ID NO：762 PMON35792.pep

AlaThrGInAspCysSerPheGlnHisSerProIleSerSerAspPheAiaValLysIleArgGluLeuSerAsp 20 TyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGIuGiuLeuCysGlyGlyLeuTrpArg LeuValLeuAlaGlnArgTrpMecGluArgLeuLysThrValAlaGlySerLysMetoinGIyLeuLeuGluArg ValAsnThrGJLu工 leHisPheValT'hrLysCysAlaPheGlnProPiroProSerCysLeuArgPheValGlnThr AsnlleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLys ProTrp二leThrArgGlnAsnPhe SerArgCysLeuGluLeuGlnTyrValGluGlyGlyGl/GlySerProGlyGlyGlySerGlyGlyGlySerAsn 25 MetAlaThrProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeuLysSerLeuGluGlnValArgLvs

LeuLeuGiyHisSerLeuGb/IleProTrpAlaProLeuSerSerCysProSerGlnAlaLeuGlnLeuAlaGiv CysLeuSeirGlnLeuHisSerGlyLeuPheljeuTyirGlnGlyLeiaLeuGinAlaLeuGluGlylleSerProGiu 、 LeuGlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAlaThrThrIleTrpGlnGlnMetGiuGla 30 LeuGlyMetAlaProAlaLeuGlnProThrGlnGlyAlaMecProAlaPheAlaSerAlaPheGlaAxgArgAIa GlyGlyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSerTyrArgValLeuArgHisLeuAlaGln Pro SEQ ID NO:763 ” PMON39905.pep

AlaThrGlnAspC'/sSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAsp TyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArg LeuValLeuAlaGlnArgTrpMetGJLuArgLeuLysThrValAlaGlySeirLysMetGinGlyLeuLeuGluArg ValAsnThrGluIleHisPheValThrLysCysAi>aPheGlnPi:oProPr〇SerCysIJeuA;rgPheValGlnThr 40 AsnlleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnP’ne SerArgCvsLeuGluLeuGlnSerGlnProAspSerSerThrLeuTyrValG.luGIyGlyGlyGlySerProGly GlyGlySerGlyGlyGlySerAsnMetAlaThrProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeu LysSerLeuGluGlnValArgLysIleGlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrTyrLys LeuCysHisPrcGluGluLeuValLeuLeuGlyHisSerLeuGlyl leProTirpAlaPiroLeuSerSerCys 45 SerGlaAlaLeuGlnLeuAlaGlyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGin AlaLeuGluGlylleSerProGluLeuGlyProThrLeuAspThrLeuGlnLeuAsp'/alAlaAspPheAlaThr Thr 工 leTi:pGlnGlrLMet:GluGlu；LeuGlyMet:Alap]：oAlaLeuGlnP；!r〇Th::GlnGlyAlaMet:P2：oAla?he AlaSerAlaPheGlnArgArgAlaGlyGlyValLeuValAlaSerHisLeuGinSerPheLeuGluValSerTyr ArgValLeuArgHisLeuAlaGinPro SEQ ID N〇：764 50 PMON39906.pep 、

AlaThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAsp 〜 TyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlyLeuTrpArg 55 LeuValLeuAlaGlriArgTrpMetGluArgLeuLysThrValAlaGlySerLysMecGlnGlyLeuLeuGluArg ValAsnThrGluIleHis?heValThrLysCysAlaPheGln?roProProSerCysLeuArgPheValGlaThr AsnlleSerArgLeuLeuGlnGluThrSerGiuGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsr.Phe SerArgArgLeuGluLeuGlnSerGlnProAspSerSerThrLeuTyrValGluGiyGlyGlyGlySerProGly GlyGlySerGlyGlyGlySerAsnMetAlaThrProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeu 6〇 LysSerLeuGiuGinVaiArgLysIleGlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrAsnLys LeuCysHisProGLuGLuLeuValLeuLeuGiyH.isSerLeuGlylleProTTrpAlaProLeuSerSerCys Pro SerGlnA 丄

AlaLeuGluGlvIleSerProGluLeuGlvProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAlaThr ThrIleTrpGlnGlnMetGluGluLeuGlyMeCAlaProAlaLeuGlnProThrGlnGlyAlaMetProAlaPhe 65 AlaSerAlaPheGIaArgArgAlaGlyGlyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSerTyr ArgValLeuArgHisLeuAlaGlnPr SEQ ID NO :7 65 pMON39909. pep

AlaAspGluGIuLeuCysGlyGiyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrVa1

AiaGlySerLysMecGlnGiyLeuLeuGluArgValAsnThrGluIlGHisPhGValTlirLysCysAiaPhGGin ProProProSerCysLeuArgPheValGlnThrAsnlleSerArgLeuLeuGlnGluThrSerGluGlnLeuVal AlaLeuLysProTrpIleThrArgGlaAsnPheSerArgCysLeuGluL.euGlnCysGlnProAspSerSerThr LeuGlyGlyGlySerGlyGlyGlySerGiyGlyGlySerGIyGlyGlySerGlyGlyGlySerGlyThrGlaAsp O:\92\92747.DOC 263 - 200413407 …· CysSerPheGinHisSerProIleSerSerAspPheAlaValLysIleArgGiuLeuSerAspTyrLeuLeuGin AspTyrProVaiThrValAlaSerAsnLeuGlnTyrVaLGluGlyGlyGlyGi'/SerPrcGlyGl/GlySerGIy GlyGlySerAsaMecAiaThrGInGiyAiaMetProAlaPheAiaSerAlaPheGlnArgArgAlaGlyGlyVal LeuValAlaSerHisLeuGlnSerPheLeuGluValSerTyrArgValLeuArgHisLeuAlaGlnProSerGIy 5 GlySefGlyGlySerGlnSerPheLeuLeuLysSerLeuGluGlnValArgLysIleGlnGlyAspGlyAlaAla

LeuGlnGluLysLeuCysAiaThrTyrLvsLeuCysHi3 ProGluGluLeuValLeuLeuGlyHisSerLeuGly IleProTrpAlaProLeuSerSerCysProSerGlnAlaLeuGlnLeuAlaGIyCysLeuSerGlnLeuHisSer GlyLeuPheLeuTyrGlaGlyLeuLeuGlnAlaLeuGluGlylleSerProGluLeuGlyProThrLeuAspThr LeuGinLeuAspVaiAlaAspPheAlaThrThrlleTrpGlnGloMetGiLiGliiLeuGlyMetAlaLProAlaLeu 10 GlnPro SEQ ID NO:7 β β ' PMCN39910.pep

AlaThirGlnGlyAlaMeCPrOAiaPheAlaSerAlaPheGlnArgAirgAlaGlyGlyValLeuValAlaSerHis 15 LeuGlnSerPheLeuGluValSerTyrArgValLeuArgHisLeuAlaGlnProSerGlyGlySerGlyGiySer GlnSerPheLeuLeuLysSerLeuGluGlnValArgLysXlsGlnGlyAspGlyAlaAlaLeuGlnGluLysLeu CysAlaThr'TyrLysLeuCysHisProGluGluLeuValLeuLeuGlyKisSerLeuGlyIleProTrpAlaPro LeuSerSerCysProSerGlnAlaLeuGlnLeuAiaGIyCysLeuSerGlnLeuHisSerGlyLeuPheLeuTyr GlnGl'/LeuLeuGinAlaLeuGiuGlyl leSer ProGluLeuGlyPrroTbirLeuAspThrLeuGlnLeuAsp'/al 20 AlaAspPheAlaThrThrIleTrpGlnGlni^etGluGluLeuGlyMetAlaProAlaLeuGlnProTyrValGiu

GlyGlyGlyGlySerProGlyGluProSerGlyProIieSerThrlleAsnProSerProProSerLysGluSer HisLysSerProAsriMetAiaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMet GluArgLeuL'/sThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheVal ThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnlleSerArgLeuLeuGlnGlu 25 ThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCys GlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGiyGlyGlySerGlyGly GlySerGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeu SerAspTyrLeuLeuGlrJ^spTyrProValThrValAlaSerAsnLeuGln SHQ ID NO :767 30 pMON35727. pep ,

AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpiMetiGluArgLeuLysThrVal ^ AlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGln 35 ProProProSerCysLeuArgPheValGlnThrAsnlleSerArgLeuLeuGlnGiuThrSerGluGlnLeuVal AlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThr LeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlvThrGlnAspCysSerPheGlnHisSer Pr◦工leSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrVal AlaSerAsnLeuGlnTyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIIeSerThrlleAsn 40 ProSerProProSerLysGluSerHisLysSerProAsnMetAlaAspGluGluLeuCysGlyGlyLeuTrpArg

LeuValLeuAlaGinArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArg ValAsnThrGluIleHisPheValThrLysCysAiaPheGlnProProProSerCysLeuArgPheValGlnThr AsnlleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaljeuLysProTrpIleThrArgGlnAsnPhe SerArgCysLeuGluLeuGlnCysGinProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGly 45 GlySerGlyGlyGlyThrGlnAspCysSer?he<3lnHisSerProIleSerSerAspPheAlaVaiLysIleArg GluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGln SEQ ID NO：763 pMON32168.pep

50 AlaAspGluGluLeuCysGlyGlyLedTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrVal AlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHis PheValThrLysCysAlaPheGln ProProProSerCysLeuArgPheVaiGlnThrAsnlleSerArgLeuLeuGlnGiuThrSerGluGlnLeuVal AlaLeuLys ProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThr L euG 1 y G1 y G1 y S e r G1 y G1 y G1 y S e r G L yG 1 yG I y S e r G1 yG 1 y G1 y S e r G i y G i y G1 y S e r G1 yT h r G1 nAs p 55 CysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGln AspTyrProValThrValAlaSerAsnLeuGlnTyrValGluGlyGlyGlyGlySerProGlyGluProSerGiy Prrol leSerThrlleAsnProSerProPjroSerLysGluSeirHisLysSerProAsnMecAlaThrGlrLAspCys SerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAsa TyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGlvGlyLeuTrpArgLeuValLeuAlaGln 60 ArgTrpMetGluArgLeuLysThrValAlaGlySerLysMecGlnGlyLeuLeuGluArgValAsnThrGluIle

HisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsnlleSerArgLeu LeuGlnGiuThrSerGluGlaLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGIu LeuGlnCysGlnProAspSerSerThrLeu SEQ ID MO :769 、 65 pMON32195.pep

AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuVaiLeuAlaGlnArgTrpMeCGluArgLeuLysThrVal AlaGIySerLysMecGlnGlyLeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGln ProProProSerCysLeuArgPheValGInThrAsnlleSerArgLeuLeuGlnGIuThrSerGIuGLnLeuVal AlaLeuLys ProTrpIleThrArgGln^.snPheSerArgCysLeuGluLeuGlnCysGLnProAspSerSerThr L.euGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyThrG LnAsp CysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGiuLeuSerAspTyrLeuLeuGln AspTyrProValThrValAlaSerAsnLeuGlnTyrValGIuGlyGlyGlyGlySerProGlyGlyGlySerGiy GlyGlySerAsnNecAlaThrProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeuLysSerLeuGlu

O:\92\92747.DOC -264 - 200413407

GlnValArqLysI LeGlr.GlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHisPro GluGLuLeuValLeuLeuGlyHisSerLeuGlyneProTrpAlaProLeuSerSerCysProSerGlnAlaLeu GlnLeuAlaGlyCysLeuSerGlnLeuHisSerGIyLeuPheLeuTyrGlnGlyLeuLeuGinAiaLeuGluGly IleSerProGiuLeuGl'/ProThrLe'oAspThrLeuGlnLeuAspValAlaAspPheAlaThrThr IleTrpG la 5 GlaMecGluGluLeuGlyMeCAlaProAlaLeuGInProThrGlnGlyAlaMetProAiaPheAlaSerAlaPhe GlnArgArgAlaGlyGlyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSerTyrArgValLeuArg HisLeuAlaGLnProTyrValGluGlyGlvOlyGlySer PrcGiyGluProSerGly Prol laSerThrl ieAsn ProSerProProSerLysGluSerHisLysSerProAsnMetAlaAspGluGluLeuCysGlyGlyLeuTrpArg LeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMecGlnGlvLeuLeuGluArg 10 ValAsnThrGluILeHis PheValThjrL'/sCysAlaPheGl_n?roProProSerCysLeuArgPhe\/alGlnThr AsnlleSerArgLeuLeuGlnGiuThrSerGluGlnLeuValAiaLeuLysProTrpIleThrArgGlnAsnPhe SerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGiy GlySerGiyGiyGlySerGlyGlyGlySerGiyThrGlnAspCysSerPheG InHisSerProIleSerSerAsp PheAlaValLvs I leArgGluLeuSerAspTyrLeuLeuGinAspTyr Pro ValThrVal A laSerAsnLeuG In 15 SEQ ID M〇 ‘ 一 PMON32I96.pep

AlaThrProLeuGiyProAlaSerSerLeuProGlnSerPheLeuLeuLysSerLeuGluGlnValArgLys lie 20 GlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrT'yrLysLeuCysHis ProGluGluLeuValLeu LeuGlyHisSerLeuGlyIleProTrpAlaProLeuSerSerCysProSerGlnAlaLeuGlnLeuAlaGlyCys LeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAiaLeuGluGlyIleSerProGIuLeu GlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAlaThrThrIleTrpGlnGlnMetGluGIuLeu GlyMetAlaProAlaLeuGlnProThrGlnGlyAlaMecProAlaPheAlaSerAlaPheGlnArgArgAlaGly 25 GlyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSerTyrArgValLeuArgHisLeuAlaGlnPro TyirValGluGlyGlyGlyGlySerPiroGlyGluProSerGlyPrQlleSerThrlleAsnPiroSerrPrQProSer LysGluSerHisLysSerProAsaMetAlaAspGiuGluLeuCysGlyGlvLeuTrpArgLeuValLeuAIaGin ArgTrpMetGluArgLeuLysThrVarAlaGlySerLysMecGlnGlyLeuLeuGiuArgValAsnThrGluIle His PheValThrLysCysAiaPheGlnProProProSerCysLeuArgPheValGlnThrAsnlleSerArgLeu 30 LeuGInGluThrSerGluGinLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCvsLeuGlu LeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGiy SerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIIeSerSerAspPheAlaValLysI Le ArgGluLeuSerAspTyrLeuLeuGloAspTyrProValThrValAlaSerAsnLeuGlnTyrValGluGlyGly GlyGlySerProGlyGiuProSerGlyProIleSerThrlleAsnProSerProProSerLysGluSerHisLys 35 SerProAsnMetAlaThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArg GluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCvsGly GlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGl7 LeuLeuGluArgValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeuArg PheValGlnThrAsnlleSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIieThr 40 ArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeu SEQ IID NO:771 PMOM32197.pep

AlaThrProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeuLysSerLeuGluGlnValArgLysIle 45 GinGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrTyrLvsLeuCysHis ProGluGluLeuValLeu LeuGlyHisSerLeuGlylLeProTrpAlaProLeuSerSerCysProSerGInAlaLeuGlnLeuAlaGlyCys LeuSerGlnLeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeuGluGiy IleSerProGIuLeu GlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAlaThrThr I leTrpGlnGlnMetGluGluLeu GlyMetAlaProAlaLeuGlnProThrGlnGlvAlaMe tProAlaPheAlaSerAlaPheGlnArgArgAlaGly 50 GlyValLeuValAlaSerHisLeuGlriSerPheLeuGluValSerTyrArgValLeuArgHisLeuAlaGlnPro TyrValGluGlyGlyGlyGlySerPr〇GlyGiuProSerGlyProIleSerThrIleAsn?roSerProProSer LysGluSerHisLysSerProAsnMetAlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGln ArgTrpMecGluArgLeuLysThrValAlaGlySerLysMet：GInGlyLeuLeuGluArgVaiAsnThrGiuIIe HisPheValThrLysCysAlaPheGlnProProPr〇SerCysLeuArgPheValGlnThrAsnIleSerArgLeu 55 LeuGlnGluThrSerGluGlnLeuValAlaLeuLys PrcTrpIleThrArgGlaAsaPheSerArgCysLeuGIu

LeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGly SerGlyGivGlySerGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysI le ArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnTyrValGluGlyGly GlyGlySerPrcGlyGluProSerGlyProIleSerThrIleAsnProSerProProSerLysGluSerHisLys 60 Ser ProAsaMetAlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpHetGiuArg LeuLysThrVaiAlaGlySerLysMetGlnGl_yLeuLeuGluArgValAsnThrGluIle‘His ?heValThrLys CysAiaPheGlnProPiroPr'oSerCysLeuArgPheValGlnThrAsnlleSerArgLeuLeuGlnGluThrSer GluGlnLeuValAlaLeuLvs ProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnPro AspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySer 65 GlyThrGLnAspCysSe::PheGlr\HisSer?r〇neSerSerAspPheAJ*a'/alLysIleArgGluIjeuSerAsp TvrLeuLeuGloAspTyrProValThrValAlaSerAsnLeuGla SEQ ID N〇：772 pMOM3 2 2 06. pep 70 AlaAsnCysSer ileMetl leAspGiuIielleHisHisLeuLysAirgProProAiaProLeuIjeuAspPiroAsn AsnLeuAsnAspGluAspValSer IleLeuiMecAspArgAsaLeuArgLeuProAsnLeuGluSerPheVaiArg AlaValLysAsnLeuGluAsnAlaSerGiylLeGLuAlalleLeuArgAsnLeuGlnProCysLeuProSerAld T'hrAiaAlaProSerArgHi^ProIlellelleLysAiaGlyAspTrpGlnGliiPheArgGiuLysLeuThrPhe TyrLeuValThrLeuGluGlrL\laGlnGluGlaGlnTyrVaIGluGlyGlyGlyGlySerProGlyGluProSer 75 GlyProIleSerThrIleAsnProSerProProSerLysGluSerHisLysSerProAsnMecAlaAspGluGiu -265 -

O:\92\92747.DOC 200413407

LeuCysG L，/G lyLeuTirpArgLeuVaiLeuAlaGlrLArgTrpMe CG 丄 uArgLeuLysThirVa· iAiaGL'/SerLys MecGinGl'/LeuLeuGiuArqValAsnThrGlulLeHisPheValThrLysCysAlaPheGlnProProProSer CysLeuArgPheValGlnThrAsnlleSerArgLeuLeuGinGluThrSerGIuGInLeuValAlaLeuLysPro TrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeaGlyGIyGly 5 SerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGiyThrGlnAspCysSerPheGin HisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProVal ThrValAlaSerAsnLeuGlnTyrValGIuGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThr IleAsnProSerProProSerLysGluSerHisLysSerProAsnHetAlaAspGluGluLeuCysGlyGlyLeu TrpArgLeuValLeuAlaGlaArgTrpMetGluArgLeuLysThrValAlaGlySerLysMetGlnGlyLeuLeu 10 GluArgValAsnThrGluIleHisPheValThrLysCysAiaPheGlnProProProSerCysLeuArgPheVal

GlnThrAsnlleSerArgLeuLeuGlnGIuThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGln AsnPheSerArgC'/sLeuGiuLeuGlnCysGlnProAspSerSerThrLeuGlyGIyGlySerGlyGlyGlySer GlyGiyGlySerGlyGlyGlySerGlyGlyGlySerGlyThrGlnAspCysSerPheGlnHisSerProIieSer SerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsn 15 LeuGin SEQ ID NO :773 ' ▲ PMON32207.pep

AlaAspGluGluLeuCysGlyGlyLeuT'rpArgLeuValLeuAlaiGlnAirgTirpMeCGluArgLeuLysThrVal 20 AlaGlySerLysMet:GlnGlyLeuLeuGlu.ArgVaiAsnThrGIuIleHisPheValThrLysCysAlaPheGIn

AlaLeuLvsProTrpIieThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThr LeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGiyGlySerGlyThrGlnAsp CysSer PheGlnHisSerProIleSerSerAspPheAla'/alLys I JLeArgGluLeuSerAspTyrLeuLeuGln 25 AspTyrProValThrValAlaSerAsnLeuGlnTyrValGluGlyGlyGlyGlySerProGLyGlyGlySerGly GlyGlySerAsnMetAlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuVaiLeuAlaGlnArgTrpMetGIu ArgLeuLiysThrValAlaGlySerLysMetGinGlyLeuLeuGluArgValAsnThrGluIleHisPheValTr.r LysCysMaPheGlnProProProSerCysLeuArgPheValGlnThrAsnlleSerArgLeuLeuGlnGluThr SerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGIuLeuGlnCysGlr. 30 ProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGi'/ SerGlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArgGluLeuSer AspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnTyrValGiuGiyGlyGlyGlySerPro GlyGluProSerGlyProIleSerThrlleAsnProSerProPrQSerLysGiuSerHisLiysSerProAsnMet AlaThrProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeuLysCysLeuGluGlnValArgLysIle 35 GlnGlyAspGlyAlaAlaLeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHisProGluGluLeuVaiLeu LeuGlyHisSerLeuGlylleProTrpAlaPiroLeuSerSerCysProSerGinAJLaLeuGinLeuAlaGlyCys LeuSerGln乙eiiHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlylleSerProGluLeu GlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAlaThrThrlleTrpGlnGlnMetGluGluLeu GlyMetAiaProAlaLeuGlnProThrGlnGlyAlaMetProAlaPheAlaSerAlaPheGlnArgArgAlaGiy 40 GlyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSerTyrArgValLeuArgHisLeuAlaGlnPro STPSTPGlySerGluPheGlySer SEQ ID NO :774 pMON35728. pep ' 45 AlaAspGluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGIuArgLeuLysThrVal

AlaGiySerL>ysMetGlnGly乙euLeuGluArgV^alAsnThrGlu工leHisPheVal^Γh:rLysCysAlaPheGl·n

ProProProSerCysLeuArgPheValGlnThrAsnlleSerArgLeuLeuGlnGluThrSerGluGlnLeuVal AlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlaCvsGlnProAspSerSerThr LeuGl'/GlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGli/ThrGinAspCysSerPheGinHisSer 50 ProIleSerSerAspPheAlaValLysk LeArgGluLeuSerAspTyrLeuLeuGlnAspTyrProValThrVal

AlaSerAsnLeuGlnTyrValGluGlyGlyGlyGlySerProGlyGluProSerGIyProIleSerThrIleAsn ProSerPrQProSerLysGluSerHisLysSerProAsnMetAlaAsnCysSeirlleMetlleAspGLuIlelie HisHisLeuLysArgProProAsnProLeuLeuAspProAsnAsnLeuAsnSerGIuAspMetAspIleLeuMe»: GluArgAsnLeuArgThrProAsnLeuLeuAlaPheValArgAlaValLysHisLeuGluAsnAlaSerGlylle 55 GluAlalleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAla?roSerArgHis?rolielieILe

LysAlaGlyAspTrpGlaGluPheArgGluLysLeuThrPheTyrLeuValThrLeuGluGlnAlaGlnGluGln GlnTyrVaiGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrlleAsnProSerProPro SerLysGluSerHisLysSerProAsnMetAlaAspGluGluLeuCysGiyGlyLeuTrpArgLeuValLeuAla GlnArgTrpMetGluArgLeuLvsThrValAlaGlySerLysMecGlnGlyLeuLeuGluArgValAsnThrGlu 60 IleHisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheVaiGlnThrAsrilleSerArg LeuLeuGlr.GluThrSerGluGlnLeuValAlaLeuLysProTrpIleThrArgGlnAsnPheSerArgCysLeu GluLeuGlnCysGlnProAspSerSerThrLeuGlyGlyGlySerGlyGlyGlySerGlyGLyGlySerGlyGIy GlyThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValL'/sIleArgGluLeuSerAsp TvrLeuLeuGlnAspTyrProVaiThrValAlaSerAsnLeuGln SEQ ID NO :77 5 65 ^ pMOM3 213 3. pep

AlaAspGluGluLeuCysGlyGLyLeuTrpArgLeuValLeuAlaGlnArgTrpMecGluArgLeuLysThrVai 70 AlaGlySerLysMecGinGlyLeuLeuGiuArgValAsnTlirGluIleHisPh^VaiThirLysCysAlaPheGin ProProProSerCysLeuArgPheValGinThrAsnlleSerArgLeuLeuGlnGiuThrSerGiuGlnLeuVal AlaLeuLys ProTrpIleThrArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThr LeuGlyGiyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlvGlySerGlyThrGlnAsp CysSerPheGlaHisSerProIieSerSerAspPheAlaValLysIleArgGluLeuSerAspTyrLeuLeuGIn 75 AspTyrProValThrValAlaSerAsnLeuGlnGluPheLysLeuGluProArgG-lyProThrIleLysProCys

O:\92\92747.DOC -266- 200413407

ProProCysLysCys ProAlaProAsnLeuLeuGlyGlyProSerValPhellePheProProLysIieLysAsp ValLeuMecIIeSerLeuSerProIieValThrCysValValValAspValSerGluAspAspProAspValGin IleSerTrpPheValAsnAsnValGluValHisThrAlaGlnThrGlnThrHisArgGluAspTyrAsnSerThr LeuArgAlaValSerAlaLeuProIleGinHisGinAspTrpMetiSerGlyLysGluPheLysCysLysValAsn 5 AsnLysAspLeuProAlaProIleGluArgThrlleSerLysProLysGlySerValArgAlaProGlnValTyr ValLeuProProProGluGluGluMetThrLysLysGlnValThrLeuThrCysMetiValThrAspPheMetPro GluAspIleTyrValGluTrpThrAsaAsnGlyLysThrGluLeuAsnTyrLysAsnThrGluProValLeuAsp SerAspGlySerTyrPheMecTyrSerLysLeuArgValGluLysLysAsnTrpValGluArgAsnSerTyrSer CysSerValValHisGluGlyLeuHisAsnHisHisThrThrLysSerPheSerArgThrProGlyLys SEQ 10 ID N〇：776 pMON3 213 4. pep

AiaT?hrGlnAspCysSerPheGlnHisSerPro!LeSerSerAspPheAlaValLysIleArgGluLeuSerAsp 15 TyrLeuLeuGlrJ^spTyrProValThrValAlaSerAsnLeuGlnAspGluGluLeuCysGlyGlvLeuTrpArg LeuValLeuAlaGlnArgTrpMecGiuArgLeuLysThrValAlaGlySerLysMeCGlnGlyLeuLeuGluArg ValAsnThrGluIleHisPheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThr Asril leSerArglieuLeuGlnGluThrSerGluGinLeuVaiAlaljeuLysPiroTirpI leThrArgGlnAsnPhe SerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeuGluPheLysLeuGluProArgGlyProThr 20 工 leLysPiroCysProPrcCysLysCysProAlaPiroAsnLeuIjeuGlyGiyProSerValPhellePheProPrQ LysIleLysAspValLeuMetlleSerLeuSerProIleValThrCysValValValAspValSerGluAspAsp ProAspValGlnlleSerTrpPheValAsnAsnValGluValHisThrAlaGlnThrGlnThrKisArgGluAsp TyrAsnSerThrLeuArgAlaValSerAlaLeuProIleGlnHisGlnAspTrpMetSerGlyLysGluPheLys CysLysValAsnAsnJLysAspLeuProAlaProIleGluArgThrIleSerLysProLysGlySerValArgAla 25 ProGlnValTyrValLeuProProProGluGluGluMetThrLysLysGlnValThrLeuThrCysMetValThr-AspPheMetProGluAspIleTyrValGluTrpThrAsnAsnGlvLysThrGluLeuAsnTyrLysAsnThrGlU ProValLeuAspSerAspGlySerTyrPheMetTyrSerLysLeuArgValGiuLysLysAsnTrpValGluArg AsnSerTyrSerCysSerValValHisGluGlyLeuHisAsnHisHisThrThrLysSerPheSerArgThrPro GlyLys SEQ 工D N〇：777 · 30 下列之實例進一步詳述本發明，惟應明暸本發明並不為此等特定實例限制。實例1 母細胞BHK表現載體之建構 A. 將Afllll位點自哺乳動物表現載體移除建構新穎之哺乳動物表現載體，以接受Ncol-Hindlll或 Afllll-Hindlll基因片段，並使其符合閱讀框構且位於hIL-3 受體促效劑pMON13146 (WO 94/12638)基因及小鼠IgG2b 連接子片段之3’。首先，將唯一之Afllll位點自pMON3934 ( 其為pM〇N3 3 59之一衍生物）移除。pMON3359係一種以 pUC 1 8為基礎之載體，其含有一哺乳動物表現基因盒。該基因盒包括單純皰疹病毒啟動子IE1 10 (-800至+120)，接續經修飾之人類IL-3信號肽序列及SV40晚期聚腺苷酸化 (poly-A)信號（其已被次選殖進入pUC 18之多連接子中（參見 O:\92\92747.DOC -267 - 200413407 ，Hippenmeyer et al·，Bio/Technology，1993, pp.1037-1041)) 。經修飾之人類IL-3信號序列（其可協助基因產物分泌至細胞外部）之兩侧係5’端之BamHI位點及3,端之獨特Ncol位點。一獨特之11丨11(1111位點位於該^^〇1位點之3’側及9〇17-八序列之5’侧。編碼該信號肽之DNA序列如下所示（限制酶位點標示於上）。Ncol位點中之ATG (甲硫胺酸）密碼子與該信號肽之起始子ATG (畫底線者）係呈符合閱讀框構之狀態。

BamHI Ncol

5' GGATCCACCATGAGCCGCCTGCCCGTCCTGCTCCTGCTCCAACTCCTGGTCCGCCCCGCCATGG (序列編號NO: 857) 以Afllll切割處理，再添加DNA聚合酶及核甞酸補齊突出端，以將唯一之Afllll位點自pMON3934移除。以Magic PCR Clean up套組（Promega)純化經切割處理之DNA片段，並以 T4 DNA稼接酶進行稼接。將稼接產物轉形進入DH5〇：tm，並將該等細胞於添加胺苄青黴素之LB-凝膠上進行平板培養。以Afllll及Hindlll之限制分析，篩選各集落Afllll位點之喪失，如ΑΠΙΙΙ位點已經移除，其即會產生單一片段。所得之質體稱為PMON30275。 B. 將hIL-3受體促效劑pMON13146 / IgG2b基因盒轉移進入 PMON30275 將取自 pMON30245 之 Ncol-Hindlll 片段（約 425 bp)與 pMON30275 之 Ncol-Hindlll 片段（約 3800 bp)稼接。 pMON30245 (WO 94/12638)含有編碼hIL-3受體促效劑卩乂01\[13146之基因連結小鼠1§〇213鉸鏈片段。於毗鄰該 O:\92\92747.DOC -268 - 200413407

IgG2b鉸鏈之3’及毗鄰該Hindlll位點之5’處即為一 Afllll位點。可將基因以Ncol-Hindlll或Aflllll-Hindlll片段之形式，以與該hIL-3變體pMON13146 / IgG2b鉸鏈呈符合閱讀框構之狀態，將基因選殖進入該Aflllll-Hindlll位點，以創造新穎之嵌合體。Ncol位點及ΑΠΙΙΙ位點具有可相容之突出端，且可進行稼接，但兩辨識位點皆會喪失。此一選殖產生質體PMON303 04，其含有（序列編號NO: 1)之DNA序列，編碼 hIL-3變體pMON13146連結小鼠IgG2b鉸鏈區域。實例2 含有二元體樣板之一拷貝c-mpl配位體（1-153)基因之中間質體之建構為產生具有c-mpl (1-153)配位體之編碼序列接續獨特 EcoRI限制位點之質體DNA，先以逆轉錄酶/聚合酶連鎖反應（RT/PCR)分離基因。人類胎（編號#38130)及成人肝（編號 #46018) A+ RNA係由 Clontech (Palo Alto, CA)取得，以作為c-mpl配位體信使RNA (mRNA)之來源。第一股之cDNA 反應係使用取自 Invitrogen (San Diego，CA)之 cDNA Cycle tm Kit進行。在RT反應中，其使用隨機引子及寡dT引子，以自人類及胎肝mRNA之組合物中產生cDNA。為擴增編碼胺基酸1-153之c-mpl配位體基因片段，以該RT產物作為樣板，進行使用下列引子組合之PCR，正向引子（Forward primer) : c-mplNcoI (序列編號NO: 317)及反向引子 (Reverse primer) : Ecompl。該 c-mplNcoI 引子可與 c-mpl 配位體基因黏連（鹼基#279-3 1 1，根據取自Gene bank編號 O:\92\92747.DOC -269 - 200413407 #L33410或 de Sauvage et al.，Nature 369:533-538 (1994)之 c-mpl配位體序列），且編碼一她鄰c-mpl配位體第一密碼子 (Ser+Ι)之5’側之Ncol限制酶位點。該Ncol限制酶位點編碼位於在Ser+Ι之前之甲硫胺酸丙胺酸密碼子，且包括該Ala 密碼子及c-mpl配位體之前四個密碼子（Ser，Pro，Ala，Pro) 之密碼子簡併性。該Ecompl引子可與c-mpl配位體之驗基 #720-73 7黏連，且編碼緊接於Arg-153之後，並符合該c-mpl 配位體基因之閱讀框構之EcoRI位點（GAATTC)。該EcoRI 位點於Arg-153之後創造Glu及Phe密碼子。純化該約480 bp 之PCR產物，以Ncol及EcoRI進行切割處理，並與pMON3 993 之 NcoI_EcoRI 載體片段（約 4550 bp.)。pMON3993 係 PMON33 5 9之衍生物（其如實例1中所述）。該人類IL-3信號肽序列（其已以BamHI片段之形式經次選殖進入介於IE110啟動子及poly-A信號間之獨特BamHI位點中）於其3’端含有一 Ncol位點，且其後緊接一獨特之EcoRI位點。此一選殖產生質體pMON26458，其含有（序列編號NO: 2)之DNA序歹|J，編碼c-mpl配位體胺基酸1_1 53 (序列編號NO: 467)。實例3 含有二元體樣板第二基因之母質體之建構為擴增始於胺基酸1 (Ser)且在胺基酸1 53 (Arg)之後具有終止密碼子之c-mpl配位體基因片段，以取自實例2之RT產物作為樣板，進行使用下列引子組合之PCR; c-mplNcoI ( 序列編號NO: 317)(正向引子）及c-mplHindlll (序列編號NO: 3 19)(反向引子）。c-mplNcoI引子係如實例2中所述。 O:\92\92747.DOC -270 - 200413407 c_mplHindIII (序列編號NO: 319)引子（其與c-mpl配位體之驗基# 71 6-73 7黏連）則在她鄰終密碼子Arg153之後之位置同時加入一終止密碼子及一 Hindlll限制酶位點。該RT cDNA樣本產生兩種類型之PCR產物，一種具有胺基酸11 2-11 5之密碼子之缺失，而另一種則無此等密碼子之缺失。以Ncol及Hindlll限制酶切割處理此等c-mpl配位體 PCR產物，以將其轉移至哺乳動物表現載體pm〇N3934中。 pMON3934已經Ncol及Hindlll切割（約3800 bp)且可接受該等PCR產物。此一選殖產生質體pMON32132 (序列編號NO: 84)，其編碼c-mpl配位體胺基酸1-1 53 (序列編號NO: 546)。此一選殖產生質體PMON32134 (序列編號NO: 86)，其編碼c_mpl配位體胺基酸1-153 (序列編號NO: 548)。此一選殖亦產生質體 pMON32133 (序列編號NO: 85)，其編碼具有密碼子ι12_115 之缺失（△ 112-115)之c-mpl配位體胺基酸1 -1 53 (序列編穿 NO: 547)。實例4 PCR二元體樣板5L (其於第二c-mpl配位體基因中具有— 112-115之缺失）之製備黏連 pMON26458 之 3.7 Kbp BstXI/EcoRI 片段， pMON32133之1 Kbp NcoI/BstXI片段（其含有胺基酸 112-115之缺失），以及£〇〇111/八01151^合成寡核苷酸連接子 5L-51 (序列編號NO: 322)及5L-3’（序列編號NO·· 323)，以建構用於製備新穎形式c-mpl配位體之PCR樣板。 O:\92\92747.DOC -271 - 200413407 該連接子之EcoRI端可與pMON26458之EcoRI端稼接。該連接子之ΑΠΙΙΙ端可與pMON32133之Ncol端稼接，且在稼接之後兩限制位點皆不會被保留。PMON26458及pMON32133 之BstXI位點亦可進行稼接。此一選殖產生質體PM0N28548 ，其含有（序列編號NO: 3)之DNA序列，其編碼經 GluPheGlyGlyAsnMet (序列編號NO: 783)連接子與含有胺基酸112 -11 5缺失之胺基酸1 -1 5 3 c - m p 1配位體融合之胺基酸1-153 c-mpl配位體（序列編號NO: 468)。實例5 PCR二元體樣板4L之製備黏連 PMON26458 之 3.7 Kbp BstXI/EcoRI 片段， PMON32132 之 lKbpNcoI/BstXI片段，以及EcoRI/AflIII4L 合成寡核苷酸連接子4L-5’（序列編號NO: 320)及4L-3’（序列編號NO: 321) j以建構用於製備新穎形式c-mpl配位體之 PCR樣板。該連接子之EcoRI端可與pMON26458之EcoRI端稼接。該連接子之ΑίΊΙΙΙ端可與pMON32132之Ncol端稼接，且在稼接之後兩限制位點皆不會被保留。pMON26458及pMON32132 之BstXI位點亦可進行稼接。此一選殖產生質體pMON28500 ，其含有（序列編號NO: 4)之DNA序列，其編碼經 GluPheGlyAsnMetAla (序列編號 NO: 223)連接子（4L)與胺基酸1-153 c-mpl配位體融合之胺基酸1-153 c-mpl配位體（序列編號NO: 469)。實例6 O:\92\92747.DOC -272- 200413407 PCR二元體樣板5L之製備黏連 pMON26458 之 3·7 Kbp BstXI/EcoRI 片段， pMON32132 之 lKbpNcoI/BstXI片段，以及EcoRI/AflIII5L 合成寡核甞酸連接子5L-5’（序列編號NO: 322)及5L-3’（序列編號NO: 323)，以建構用於製備新穎形式c-mpl配位體之 PCR樣板。該連接子之EcoRI端可與pMON26458之EcoRI端稼接。該連接子之Afllll端可與pMON32132之Ncol端稼接，且在稼接之後兩限制位點皆不會被保留。PMON26458及pMON32132 之BstXI位點亦可進行稼接。此一選殖產生質體PMON28501 ，其含有（序列編號NO: 4)之DNA序列，編碼經 GluPheGlyGlyAsnMet (序列編號 NO: 783)連接子（5L)與胺基酸1-153 c-mpl配位體融合之胺基酸1-153 c-mpl配位體（序列編號NO·. 470)。實例7 PCR二元體樣板8L之製備黏連 pMON26458 之 3.7 Kbp BstXI/EcoRI 片段， pMON32134 之 lKbpNcoI/BstXI片段，以及EcoRI/AflIII8L· 合成寡核苷酸連接子8L-5’（序列編號NO: 324)及8L-3’（序列編號NO: 325)，以建構用於製備新穎形式c-mpl配位體之 PCR樣板。該連接子之EcoRI端可與pMON26458之EcoRI端稼接。該連接子之Afllll端可與PMON32134之Ncol端稼接，且在稼接之後兩限制位點皆不會被保留。PMON26458及pMON32134

O:\92\92747.DOC -273 - 200413407 之BstXI位點亦可進行稼接。此一選殖產生質體pM〇N28502 ，其含有（序列編號NO·· 6)之DNA序列，且編碼經

GluPheGlyGlyAsnGlyGlyAsnMetAla (序列編號NO: 224)連接子（8L)與胺基酸^53 c-mpl配位體融合之胺基酸1-153 c-mpl配位體（序列編號NO: 471)。實例8-44 具有新穎N-端及C-端之新穎c-mpl配位體基因之製備 A·以PCR製備編碼新穎c-mpl配位體受體促效劑之基因使用方法III (Horlick et al·，Prot· Eng. 5:427-433，1992) 製備編碼新穎c-mpl配位體受體促效劑之基因。PCR反應係使用二元體樣板（1)%€^28500、28502、28502、或 28584)以及下列合成引子組之一進行（在下列引子組中，第一個數字係指原始序列中第一胺基酸之位置。舉例而言’ 3 1 - 5 ’及3 14 係分別代表用於製備始於對應原始序列殘基3 1之密碼子之序列的5’及3’寡引子。） 31-5，（序列編號NO: 326)及31-3，（序列編號NO: 327)， 35-5f (序列編號NO·· 328)及 35-3,（序列編號NO: 329)，39-5’ (序列編號NO: 330)及39-3,（序列編號NO: 331)，43-5’（序列編號NO: 332)及43-3’（序列編號NO: 333) ’ 45-5’（序列編號 NO: 334)及 45-3,（序列編號NO: 335)，49-5’（序列編號NO: 336)及49-3,（序列編號NO: 337)，82-5f (序列編號NO·· 338) 及82-3’（序列編號NO: 339)，109-5’（序列編號NO: 340)及 109-3，（序列編號NO: 341)，115-5，（序列編號NO: 342)及 115-3f (序列編號 NO: 343)，120-5f (序列編號 NO: 344)及 O:\92\92747.DOC -274- 200413407 120-3’（序列編號NO: 345)，123-5’（序列編號NO: 346)及 123-3’（序列編號NO: 347)，126-5’（序列編號NO: 348)及 126-3’（序列編號NO: 349)。用於此等PCR反應中之樣板及寡核甞酸組如表4所示。所產生之產物約為480 bp，且以Magic PCR Clean up套組 (Promega)純化。 B. 將新穎之c-mpl配位體受體促效劑基因產物次選殖進入哺乳動物表現載體中以製備嵌合體以Ncol及Hindlll，或Afllll及Hindlll限制酶切割處理該等新穎之c-mpl配位體受體促效劑基因產物（約470 bp)，以將其轉移至哺乳動物表現載體中。表現載體PMON30304已經 Ncol 及 Hindlll 切割（約 4200 bp)，且可接受 Ncol-Hindlll 或 Afllll-Hindlll片段形式之PCR產物。該等PCR產物之限制性切割處理及所得之產物如表4所示。 O:\92\92747.DOC -275 - 200413407 表4 PCR PCR產物所得 c-mpl配位實例# PCR 產物限制性連接子質體體中之樣板引子切割處理 pMON 斷裂點對實例8 pMON28501 31 Ncol/Hindlll 5L 28505 30-31 實例9 pMON28501 35 Afllll/HindHI 5L 28506 34-35 實例10 PMON28501 39 Ncol/Hindlll 5L 28507 38-39 實例11 PMON28501 43 Ncol/Hindlll 5L 28508 42-43 實例12 pMON28501 45 Ncol/Hindlll 5L 28509 44-45 實例13 pMON28501 49 Ncol/Hindlll 5L 28510 48-49 實例14 pMON28501 82 Ncol/Hindlll 5L 28511 81-82 實例15 pMON.28501 109 Ncol/Hindlll 5L 28512 108-109 實例16 pMON28501 116 Ncol/Hindlll 5L 28513 115-116 實例17 pMON28501 120 Ncol/Hindlll 5L 28514 119-120 實例18 pM〇N28501 123 Ncol/Hindlll 5L 28515 122-123 實例19 pMON28501 126 Ncol/Hindlll 5L 28516 125-126 實例20 pMON28500 31 Ncol/Hindlll 4L 28519 30-31 實例21 pMON28500 35 Afllll/HindHI 4L 28520 34-35 實例22 pMON28500 39 Ncol/Hindlll 4L 28521 38-39 實例23 pMON28500 43 Ncol/Hindlll 4L 28522 42-43 實例24 pMON28500 45 Ncol/Hindlll 4L 28523 44-45 實例25 pMON28500 49 Ncol/Hindlll 4L 28524 48-49 O:\92\92747.DOC -276 200413407 表4續實例# 實例26 實例27 實例28 實例29 實例30 實例31 實例32 實例33 實例34 實例35 實例36 實例37 實例38 實例39 實例40 實例41 實例42 實例43 實例44 PCR PCR產物所得 c-mpl配位 PCR 產物限制性連接子質體體中之樣板引子切割處理 pMON 斷裂點對 pMON28500 82 Ncol/Hindlll 4L 28525 81-82 pMON28500 109 Ncol/Hindlll 4L 28526 108-109 PMON28500 116 Ncol/Hindlll 4L 28527 115-116 pMON28500 120 Ncol/Hindlll 4L 28528 119-120 pMON28500 123 Ncol/Hindlll 4L 28529 122-123 pMON28500 126 Ncol/Hindlll 4L 28530 125-126 pMON28502 31 Ncol/Hindlll 8L 28533 30-31 pMON28502 35 AflUI/Hindlll 8L 28534 34-35 pMON28502 39 Ncol/Hindlll 8L 28535 38-39 pMON28502 43 Ncol/Hindlll 8L 28536 42-43 pMON28502 45 Ncol/Hindlll 8L 28537 44-45 pMON28502 49 Ncol/Hindlll 8L 28538 48-49 pMON28502 82 Ncol/Hindlll 8L 28539 81-82 pMON28502 109 Ncol/Hindlll 8L 28540 108-109 pMON28502 116 Ncol/Hindlll 8L 28541 115-116 pMON28502 120 Ncol/Hindlll 8L 28542 119-120 pMON28502 123 Ncol/Hindlll 8L 28543 122-123 pMON28502 126 Ncol/Hindlll 8L 28544 125-126 pMON28548 123 Ncol/Hindlll 5L 28545 122-123

O:\92\92747.DOC -277 - 200413407 實例45 pMON15960之建構建構pMONl 5960，其為一中間質體，用於建構含有編碼具有新N-端及C-端之G-CSF Ser17之DNA序列之質體。以限制酶Hindlll及BamHI切割處理質體PACYC177 (Chang， A.C.Y. and Cohn? S.N. J. Bacteriol. 13 4:1 141-1 156) DNA 5 得到3092鹼基對之Hindlll、BamHI片段。以Bglll及FspI切割處理質體 pMON 13037 (WO 95/21254) DNA，得到 61 6驗基對之Bglll、FspI片段。以Ncol及Hindlll切割處理第二樣本之質體pMONl 3037 DNA，得到 556鹼基對之Ncol、Hindlll 片段。使合成DNA寡核苷酸IGGGSfor (序列編號NO: 380) 及lGGGSrev (序列編號NO: 381)互相黏連，並以ΑΠΙΙΙ及 FspI對其進行切割處理，得到21鹼基對之ΑΠΙΙΙ、FspI片段。稼接此等限制片段，並使用稼接反應混合物轉形大腸桿菌K-12菌株JM101。於含有胺苄青黴素之培養平板上篩選轉形株菌。分離質體DNA並以限制分析進行分析，以確認正確之插入子。實例46 pMON15981之建構建構pMONl 5 981，其為含有編碼一多功能造血素受體促效劑之DNA序列之質體。以限制酶Smal切割處理質體 pM〇N15 960 DNA，並以其作為樣板，用於使用合成DNA寡核嘗酸38 stop (序列編號NO: 369)及39 start (序列編號no: 368)作為引子之PCR反應中，得到一 576鹼基對之DNA片段 O:\92\92747.DOC -278 - 200413407

擴增物。以限制酶Hindlll及Ncol切割處理該經擴增之片段，得到558鹼基對之Hindlll、Ncol片段。以Hindlll及Afllll 切割處理質體pMON 13 1 81 DNA，得到4068鹼基對之Hindlll 、Afllll片段。稼接此等限制片段，並使用稼接反應混合物轉形大腸桿菌K-12菌株JM1 01。於含有胺苄青黴素之培養平板上篩選轉形株菌。分離質體DNA，以限制分析進行分析，並進行定序，以確認正確之插入。質體pMONl 5981含有（序列編號NO: 78)之DNA序列，其編碼下列胺基酸序列：

MetiAlaAsnCysSexrlleMeCileAsipGIullGlleHisHisLeuLysAirgPrcjPi'CJAld

ProL^uLeuAspProAsnAsnLeuAsnAspGluAspValSerlleLeuMetAspArgAsn

LeuArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSer

GlylleGluAlalleLeuArgAsnljeuGliaProCysLeuProSerAlaThirAlaAlaPro

SerAirgiiisPjro 工 lellelleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThr

PheTyrrjeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGly

SerPrcjGlyGluPrc^erGlyProIleSerThrlleAsnProSerProPxruSerLyaGlu

SerHisLys Ser ProAsnMetAlaTyrLysLeuCy^H i sProG luGluT.euVa 1T

GlyHisSerLeuGlylleProTrpAlaProLeuSerSerCysProSerGlnAlaLeuGln

AlaAspPheAlaThrThrlleTrpGlnGlnMetGluGluLeuGlyMetAlaProAlaLeu GlnProThrGlnGlyAlaMetProAlaPheAlaSerAlaPheGlnArgArgAlaGlyOly V^lLeuVciiAlaSerHisLeuGlnSexPheLeuGluValSerTyrAxgValLeuArgHis LeuAlaGlnProGlyGlyGlySerAspMetAlaThrProLeuGlyProAlaSerSerLeu ProGlnSerPheLeuLeuLysSerLeuGluGlnValArgLysIleGlnGlyAspGlyAla Al^LeuGlnGluLysLeuCysAlaThr Λ (SEQ XD NO :500) (序列編號NO: 500) 實例47 pMON15982之建構建構pMONl 5982，其為含有編碼一多功能造血素受體促效劑之DNA序列之質體。以限制酶Smal切割處理質體 pMONl 5960 DNA，並以其作為樣板，用於使用合成DNA寡核苷酸96 stop (序列編號NO: 371)及97 start (序列編號NO: O:\92\92747.DOC -279- 200413407 370)作為引子之PCR反應中，得到一 576鹼基對之DNA片段擴增物。以限制酶Hindlll及Ncol切割處理該經擴增之片段，得到558鹼基對之Hindlll、Ncol片段。以Hindlll及Afllll 切割處理質體pMON13181 DNA，得到4068鹼基對之Hindlll 、Afllll片段。稼接此等限制片段，並使用稼接反應混合物轉形大腸桿菌K-12菌株JM101。於含有胺芊青黴素之培養平板上篩選轉形株菌。分離質體DNA，以限制分析進行分析，並進行定序，以確認正確之插入。質體pMONl 5982含有（序列編號NO: 79)之DNA序列，其編碼下列胺基酸序列：

MetAlaAsnCysSerlleMetlleAspGluIlelleHisHisLeuI/ysArgProProAla ProLeuLeuAspProAsnAsnLeuAsnAspGluAspValSerlleLeuMetAspArgAsn LeuArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSer GlylleGluAlalleLeuArgAsnLeuGlnProCysIjeuProSerAlaThrAlaAlaPro SerArgHisProIlellelleLysAl&GlyAspTrpGlnGluPheArgGluLYsLeuThr PheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGly^lyGlyGly SerProGlyGluProSerGlyProIleSerThrlleAsnProSerProProSerLysGlu SerHisLy$SerPr〇AsnMetAlaProGluLeuGlyProThrLeuAspThrLeuGlnLe\J Α3ρνα1Α1θΑ3ρΡ1ΐθΑ1&Ί1ϋΐ:ΤϊΐΓ：Ι；1θΤι:：ρ(?1η0ΐΓίΜ«ΐ01ιι01νιΙ^ί\ιΟ1：/Μθζ:Α1^Ρι:ο AlaljeuGlnProTIirGlriGlyAlaMetiProAlaPheAlaSerAlaPheGlnArgArgAla GlyGlyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSerTyrArgValLeu ArgHisLeuAlaGlnProGlyGlyGlySerAspMetAlaThrProLeuGlyProAlaSer SerlaeuProGlriSeirPheLieii 丄 nValAirgliysI leG 丄 nGlyAsp

GlyAlaA.laLeuGlnGluLysLeuCysAlaThxTyrLysLeuCysHisProGluGluLeu ValLeuLeuGlyHisSerLeuGlylleProTrpAlaProLeuSerSerCysProSerGln AlaLeuGlnLevLAlaGlyCysLouSer^lnLeviHisSerGlyLeuPheLeuTyrGlnGly LeuLeuGlnAlaLeuGluGlylleSer (SEQ 工D NO:5 01> (序列編號NO: 501) 實例48 pMON15965之建構建構pMONl 5 965，其為含有編碼一多功能造血素受體促效劑之DNA序列之質體。以限制酶Smal切割處理質體 pMONl 5 960 DNA，並以其作為樣板，用於使用合成DNA寡 O:\92\92747.DOC -280- 200413407 核苷酸142 stop (序列編號NO: 377)及141 start (序列編號 NO·· 376)作為引子之PCR反應中，得到一 576鹼基對之DNA 片段擴增物。以限制酶Hindlll及Ncol切割處理該經擴增之片段，得到558鹼基對之Hindlll、Ncol片段。以Hindlll及 Afllll切割處理質體pm〇N13181 DNA，得到4068鹼基對之 Hindlll、Afllll片段。稼接此等限制片段，並使用稼接反應混合物轉形大腸桿菌K-12菌株JM1 0 1。於含有胺苄青黴素之培養平板上篩選轉形株菌。分離質體DNA，以限制分析進行分析，並進行定序，以確認正確之插入。質體 PMON15965含有（序列編號ΝΟ_· 80)之DNA序列，其編碼下列胺基酸序列：

MetAlaAsnCysSerlleMetlleAspGluIlelleHisHisLeuLysArgProProAla

LeuArgLeuProAsnLeuGluSerPheValArgAl aValLysAsnLeuGluAsnAlaSer GlylleGluAlalleLeuArsAsnLeuGlnProCysLeuProSerAlaThrAlaAlaPro SerAirgHisPiroIlelle 工 1«Ιιγ3Α]^01：/Α3ρΤΓρα1η01\χΕ>1ΐΘΑΓ9〇1ΐΐΙιγ*3ΐαθαΤΐπ： PheTyrLeuValThrLeuGluGlnAlaGTnGluGlnGlnTyrValGluGlyGlyGlyGly 3β:ι:ΡΓ〇α1γα1\ιΡι:ο5θΓαΐγΡι:οΙ1θ3〇ΓΤΐιτΙΐ€：Α3ηΡ;ι:ο3(^Ρι*οΡ3：ο；2〇3：Ι»γ·3〇1τα SerHisLysSerProAsnMetAlaSerAlaPheGlnArgArgAlaGlyGlyValLeuVal AlaSerHisLeuGlnSerPh.eLeuGluValSerTyrArgVa.lLeuArgHisLeuAlaGln ProGlyGlyGlySerAspMetAlaThrProLeuGlyProAlaSerSerLeuProGlnSer PheLeuLeuLy s Ser LeuGluGlnVal ArgLys 11 eGlnG lyAs pG lyA 1 aAl aLeuG In GluLysLeuCysAlaThrTyrLysLeuCYsHisProGluGluLeuValLeuLeuGlyHis

GlyCysLeuSerGlnX-euHisS^rGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeu GluGly工leSerProGluLeuGlyProThrLieuAspThrLeuGlnLeuAspV^lAlaAsp PheAlaThrThrlleTrpGlnGlnMetGluGluIjeuGlyMetAlaPiroAleiLieuGlnPro ThrGlnGlyAlaMetProAlaPheAla (SEQ ID NO :502) (序列編號NO: 502) 實例49 pMON15966之建構建構pMON 15966，其為含有編碼一多功能造血素受體促 O:\92\92747.DOC - 281 - 200413407 效劑之DNA序列之質體。以限制酶Smal切割處理質體 pMON15 960 DNA，並以其作為樣板，用於使用合成DNA寡核甞酸126 stop (序列編號NO: 372)及125 start (序列編號 NO·· 373)作為引子之PCR反應中，得到一 576鹼基對之DNA 片段擴增物。以限制酶Hindlll及Ncol切割處理該經擴增之片段，得到558鹼基對之Hindlll、Ncol片段。以Hindlll及 Afllll切割處理質體PM0N13181 DNA，得到4068鹼基對之 Hindlll、ΑΠΙΙΙ片段。稼接此等限制片段，並使用稼接反應籲混合物轉形大腸桿菌K-12菌株JM1 01。於含有胺爷青徽素之培養平板上篩選轉形株菌。分離質體DNA，以限制分析進行分析，並進行定序，以確認正確之插入。質體 pMON15966含有（序列編號NO: 81)之DNA序列，其編碼下列胺基酸序列：

MetAlaAsnCysSerlleMetlleAspcruIlelleHisHisLcuLysArgProProAlai

LeuArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlaSer GlylleGluAlalleLeuArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaPr。 SerArgHisProIlellelleLysAlaGlyAspTrpGlnGluPheArgGluLysLeuThr PheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGly SerProGlyGluProSerGlyPro丄leSerThr工leAsnProSerProProSerLysGlu SerHisLysSerProAsnMetAlaMetAlaProAlaLe\iGlnProThrGlnGlyAlaMet ProAlaPheAlaSerAlaPheGlnArgArgAlaGlyGlyValLeuValAlaSerHisLeu GlnSerPheLeuGluValSerTyrArgValLeuArgHisLeuAlQGlnProGlyGlyGly SerAspMetAlaThrProLeuGlyProAlaSerSerLeuProGlnSerPheLeuLeuLys

ProTrpAlaProLeuSerSerCysProSerGlnAlaLeuGlnLeuAlaGlyCysLeuSer ΡιτσΟΙυΙίθυ^ΙγΡχΌΤΐυΓί^^ιΑΒρΤίιΐΓΐ^ιιαίηΙϋβλίΑθρναΐΑΐαΑ^ρΡ^ιβΑΙδίΤϊ^ΤΙιι: 11 eTrpG 1 nGlnMetG 1 uGluLeuGly (SEQ ID NO:5Q3) (序列編號NO: 503) 實例50 pMON15967之建構 O:\92\92747.DOC 282 - 200413407

建構pMONl 5967，其為含有編碼一多功能造血素受體促效劑之DNA序列之質體。以限制酶Smal切割處理質體 pMON15960 DNA，並以其作為樣板，用於使用合成DNA寡核苷酸132 stop (序列編號NO: 375)及133 start (序列編號 NO: 374)作為引子之PCR反應中，得到一 576鹼基對之DNA 片段擴增物。以限制酶Hindlll及Ncol切割處理該經擴增之片段，得到558鹼基對之Hindlll、Ncol片段。以Hindlll及 Afllll切割處理質體pMON13181 DNA，得到4068鹼基對之 Hindlll、ΑΠΙΙΙ片段。稼接此等限制片段，並使用稼接反應混合物轉形大腸桿菌K-12菌株JM101。於含有胺苄青黴素之培養平板上篩選轉形株菌。分離質體DNA，以限制分析進行分析，並進行定序，以確認正確之插入。質體 pMON15967含有（序列編號NO: 82)之DNA序歹J，其編碼下列胺基酸序列：

MetAlaAsnCysSerlleMetlleAspGluIlelieHisHisLeuLysArgProProAla Τ?τ:〇τ：ι€κιΙΆυΑί5ρΡΓ〇Α5πΑ8ηΙιβιιΑ5ηΑ5ρ(31ιιΑβρν3ΐ；5βι·工 leLeuMetAspArgAsn LeuArgLeuProAsnLeuGluSerPheValArgAlaValLysAsnLeuGluAsnAlQSer GlylleGluAlalleLeiiArgAsnLeuGlnProCysLeuProSerAlaThrAlaAlaPro SerArgHisProIlellelleLYsAlaGlyAspTrpGlnGluPheArgGluLysLeuThr PheTyrLeuValThrLeuGluGlnAlaGlnGluGlnGlnTyrValGluGlyGlyGlyGly SerProGlyGluProSerGlyProIleSerThi:工 leAsnProSerProProSerljysGlii SerHisLysSerProAsnMetAlaThrGlnGlyAlaMetProAlaPheAlaSerAlaPhe GlnAzgArgAlaGlyGlyValLeuValAlaSerHisLeuGlnSerPheLeuGluValSer TyrArgValLeuArgHisIieuAlaGlnProGlyGlyGlySe-rAspMetAlaTbrProLeu GlyProAlaSerSerLeuProGlnSerPheLeuLeuLysSerLeuGluGlnValArgLys

ProGluGluLeuValLeuLeuGlyHisSerLeuGlylleProTrpAlAProLeuS^rSer

CysProSerGlnAlaLeuClriLeuAlaGlyCyGLouScrGlnLeuHisSerGlyLeuPhe LeuTyrGlnGlyLeuLeuGlnAlaLeuGluGly 工 leSerProGluLeuGlyProThrLeu AspThrLeuGlnLeuAspValAlaAspPheAlaThrThrlleTrpGlnGlriMeCGluGlu LeuGlyMetAlaProAlaLeuGlnPro SEQ ID NO: 504 (序列編號NO: 504) 實例51 O:\92\92747.DOC -283 200413407 pMON13180之建構，其為一中間質體，用於建構含有編碼多功能造血素受體促效劑之DNA序列之質體以限制核酸内切酶Xmal及SnaBI切割處理質體 pMON13046 (WO 95/21254) DNA，得到 4018鹼基對之載體片段。使用 Magic DNA Clean-up Sustem 套組（Promega， Madison，WI)純化該4018鹼基對之Xmal-SnaBI片段，該片段未保有該25鹼基對之Xmal-SnaBI插入子片段。設計合成寡核甞酸之互補對，glyxal (序列編號NO: 378)及glyxa2 ( ^ 序列編號NO: 379)，以除去編碼因子Xa切割位點之序列。在適當組裝時，此等寡核苷酸亦可產生Xmal及SnaBI終端。在黏連緩衝溶液中（20 mM Tris-HCl，pH 7.5m 10 mM MgC12， 50 mM NaCl)，將引子glyxal及glyxa2於70°C下加熱10分鐘，再將其緩慢冷卻，以使其進行黏連。使用T4 DNA聚合酶 (Boehringer Mannheim， Indianapolis， IN)，使取自 pMON13 046之4018鹼基對XmaI-SnaBI片段與經組裝之寡核嘗酸進行稼接。使用部分之稼接反應物轉形大腸桿菌菌株 · DH5 α 細胞（Life Technologies，Gaithersburg，MD)。於含有胺苄青黴素之培養平板上篩選轉形株菌。自轉形株中分離質體DNA，並使用基於PCR之分析進行分析。對取自經篩選轉形株中之質體DNA進行定序，以確認寡核苷酸之正確插入。所得之質體稱為pMONl 3180 (序列編號NO: 88)。實例52 pMON13181之建構，其為一中間質體，用於建構含有編碼多功能造血素受體促效劑之DNA序列之質體 O:\92\92747.DOC -284 - 200413407 以限制核酸内切酶Xmal及SnaBI切割處理質體 pM〇N13047 (WO 95/21254) DNA，得到 4063 鹼基對之載體片段。使用 Magic DNA Clean-up Sustem 套組（Promega， Madison，WI)純化該4063驗基對之Xmal-SnaBI片段，該片段未保有該25鹼基對之Xmal-SnaBI插入子片段。設計合成寡核嘗酸之互補對，glyxal (序列編號NO: 378)及glyxa2 ( 序列編號NO: 379)，以除去編碼因子Xa切割位點之序列。在適當組裝時，此等寡核苷酸亦可產生Xmal及SnaBI終端。φ 在黏連緩衝溶液中，將引子glyxal及glyxa2於70°C下加熱1 〇分鐘，再將其緩慢冷卻，以使其進行黏連。使用T4 DNA聚合酶（Boehringer Mannheim，Indianapolis，IN)，使取自 pMON 13 047之4063鹼基對Xmal-SnaBI片段與經組裝之寡核苷酸進行稼接。使用部分之稼接反應物轉形大腸桿菌菌株 DH5 α 細胞（Life Technologies，Gaithersburg，MD)。於含有胺苄青黴素之培養平板上篩選轉形株菌。自轉形株中分離質體DNA，並使用基於PCR之分析進行分析。對取自經篩 _ 選轉形株中之質體DNA進行定序，以確認寡核苷酸之正確插入。所得之質體稱為PM0N13181 (序列編號NO: 87)。實例53 PMON13182之建構使用述於「材料及方法」乙節中之方法I創造pMONl3 182 中之新N-端/C-端基因。使用引子組39 start (序列編號N〇： 368)及 L-ll start (序列編號NO: 364)，自 PM〇N13037 中之 G-CSF Ser17序列創造並擴增片段起點（Fragment Start)。使 O:\92\92747.DOC -285 - 200413407 用引子組38 stop (序列編號NO: 369)及L-11 stop (序列編號 NO: 365)，自pMON13037中之G-CSF Ser17序列創造並擴增片段終點（Fragment Stop)。使用引子39 start及38 stop，自經黏連之片段起點及片段終點創造並擴增全長之新N-端 /C-端 G-CSF Ser17基因。以限制核酸内切酶Ncol及Hindlll切割處理含有新基因之所得DNA片段，並使用Magic DNA Clean-up Sustem套組 (Promega，Madison，WI)進行純化。以限制核酸内切酶 Hindlll及ΑΠΙΙΙ切割處理中間質體pMON13180 ，得到4023 鹼基對之載體片段，並使用Magic DNA Clean_up Sustem套組（Promega，Madison，WI)進行純化。結合經純化之限制片段，並使用 T4 DNA 聚合酶（Boehringer Mannheim， Indianapolis，IN)進行稼接。使用部分之稼接反應物轉形大腸桿菌菌株 DH5 α 細胞（Life Technologies，Gaithersburg， MD)。於含有胺苄青黴素之培養平板上篩選轉形株菌。分離質體DNA，並進行定序，以確認正確之插入。所得之質體稱為 PMON13182。以PMON13182轉形大腸桿菌菌株JM101，以進行蛋白質表現，並自包含體内分離蛋白。質體PMON13182含有（序列編號NO: 17)之DNA序歹J，其編碼下列胺基酸序列： O:\92\92747.DOC -286 - 200413407

Asn Cys Ser He Met lie Asp Glu He lie His His Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala· Ala Pro Ser Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu Lys Leu Thx Phe Tyr Leu Val Tiir Leu Glu Gin Ala Gin Glu Gin Gin Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Gly Gly Ser Gly Gly Gly Ser Asr Met Ala Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie Ser Pro Glu Leu Gly Pro Thx Leu Asp Thr Leu Gin Leu Asp Val Ala Asp Phe Ala Thr Thr lie Trp Gin Gin Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gin Pro

Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gin Arg Arg Ala Gly (51y Va丄 Leu Val Ala Ser His Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro Ser Gly Gly Ser Gly Gly Ser Gin Ser Phe Leu Leu Lys Ser Leu Glu Gin Val Arg Lys Up. Gin Gly Asp Gly Ala Ala Leu Gin Glu Lys Leu Cys Ala Thr ($£Q ID NO :472) (序列編號NO: 472) 實例54 pMON13183之建構使用述於「材料及方法」乙節中之方法I創造pMONl 3 183 中之新N-端/C-端基因。使用引子組39 start (序列編號NO: 368)及 L-ll start (序列編號 NO: 364)，自 pMON13037 中之 G-CSF Ser17序列創造並擴增「片段起點（’’Fragment Start”) 」。使用引子組38 stop (序列編號NO: 369)及L-11 stop (序列編號NO: 365)，自pMON13037中之G_CSF Ser17序列創造並擴增片段終點（Fragment Stop)。使用引子39 start及38 stop，自經黏連之片段起點及片段終點創造並擴增全長之新 N-端/C-端 G-CSFSer17 基因。以限制核酸内切酶Ncol及Hindlll切割處理含有新基因之所得DNA片段，並使用Magic DNA Clean-up Sustem套組 O:\92\92747.DOC -287- 200413407 (Promega，Madison, WI)進行純化。以限制核酸内切酶 Hindlll及Afllll切割處理中間質體pm〇N13181 ，得到4068 驗基對之載體片段’並使用Magic DNA Clean-up Sustem套組（Promega，Madison，WI)進行純化。結合經純化之限制片段’並使用 T4 DNA 聚合酶（Boehringer Mannheim， Indianapolis, IN)進行稼接。使用部分之稼接反應物轉形大肪寺干囷囷株 DH5 α 細胞（Life Technologies，Gaithersburg， MD)。於含有胺苄青黴素之培養平板上篩選轉形株菌。分離質體DNA，並進行定序，以確認正確之插入。所得之質體稱為 PMON13183。以pMON13183轉形大腸桿菌菌株JM101，以進行蛋白質表現，並自包含體内分離蛋白。質體PMON13183含有（序列編號NO: 18)之DNA序列，其編碼下列胺基酸序列：

Asn Cys Ser lie MeL lie Asp Glu lie 工le His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg A-la Val Lys Asn Leu Glu Asn Ala Ser Gly 11^

Giu Ala lie Leu Arg Asn Leu Gin Pro Cys L$u Pro Ser Ala Thr

Ala Ala Pro Ser Arcf His Pro He lie lie Lys Ala Gly Asp Trp

Gla Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gin Ala Gin Glu Gin Gin Tyr Val Glu Gly Gly Gly Gly Ser Pro

Gly Glu Pro Ser Gly Pro lie Ser Thr lie Asn Pro Ser Pro Pro

Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Tyr T.ys Leu Cys

His Pro Glu Glu Leu Val Leu Leu Qly His Ser Leu Gly lie Pro

Trp Ala Pro Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu Ala 〇ly Cys Leu Ser Gin Leu His Ser Gly Php. L^u Tyr Gin Gly

Leu Leu Gin Ala Leu Glxa Gly He Ser Pro Glu L台u Gly Pro Thr

Leu Asp Thr Leu Gin Leu Asp Val Ala Asp Phe Ala. Thr Thr lie

Trp Gin Gin Met Glu Glu Leu Gl.y Met Ala Pro Ala Leu Gin Pro

Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gin. Arg Arg

Ala Gly Gly Val Leu Val Ala Ser his Leu Gin Ser Phe Leu Glu

Val Ser Tyr Arg Val Leu Arg His T.eu Ala Gin Pro Ser Gly Gly

Ser Gly Gly Ser Gin Ser Phe Leu Leu Lys Ser Leu Glu Gin Val

Arg Lys lie Gin Gly Asp Gly Ala Ala Leu Gin Glu Lys Leu Cys

Ala Thr (SEQ ID NO :473) O:\92\92747.DOC -288 - 200413407 (序列編號NOM73) 實例55 pMON13184之建構使用述於「材料及方法」乙節中之方法I創造pMONl 3 184 中之新N-端/C-端基因。使用引子組97 start (序列編號NO: 370)及 L-ll start (序列編號 NO: 364)，自 pMON13037 中之 G-CSF Ser17序列創造並擴增片段起點（Fragment Start)。使用引子組96 stop (序列編號NO: 371)及L-ll stop (序列編號鲁 NO: 365) ^自pMONl 3 037中之G-CSF Ser17序列創造並擴增片段終點（Fragment Stop)。使用引子97 start及96 stop，自經黏連之片段起點及片段終點創造並擴增全長之新N-端 /C-端 G-CSF Ser17基因。以限制核酸内切酶Ncol及Hindlll切割處理含有新基因之所得DNA片段，並使用Magic DNA Clean-up Sustem套組 (Promega，Madison，WI)進行純化。以限制核酸内切酶 Hindlll及Afllll切割處理中間質體pMON13180 ，得到4023 φ 鹼基對之載體片段，並使用Magic DNA Clean-up Sustem套組（Promega，Madison，WI)進行純化。結合經純化之限制片段，並使用 T4 DNA 聚合酶（Boehringer Mannheim， Indianapolis，IN)進行稼接。使用部分之稼接反應物轉形大腸桿菌菌株 DH5 α 細胞（Life Technologies，Gaithersburg， MD)。於含有胺苄青黴素之培養平板上篩選轉形株菌。分離質體DNA，並進行定序，以確認正確之插入。所得之質體稱為 PMON13184。 O:\92\92747.DOC -289 - 200413407 以pMON13184轉形大腸桿菌菌株JM101，以進行蛋白質表現，並自包含體内分離蛋白。質體PMON13184含有（序列編號NO: 19)之DNA序列，其編碼下列胺基酸序列：

Asn Cy3 Ser lie Met lie hsp Glu lie lie His His Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val Ser lie Leu Met Asp Arg Asti Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie Leu Arg Asn T^eu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro lie lie lie Lys Gly Asp Trp Gin Glu Phe Arg Glu Ly3 Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gin Ala Gin Glu Gin Gin Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Gly Gly Ser Gly Gly Gly Ser Asn Ala Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala Asp Phe Ala Thr Thr lie Trp Gin Gin Met Glu Glu Leu Gly Mot Ala Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala. Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser Hia L«u Gin S«i Pli^ Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro Ser Gly Gly Ser Gly Gly Ser Gin Ser Phe Leu Leu Lys Ser Leu Glu Gin Val Arg Lys lie Gin Gly Asp Gly Ala Ala Leu Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala. Pro Leu Ser Ser Cys Pro Ser Gin Ala L^u Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu L^u Gin Ala Leu Glu Gly He Ser (SEQ ID NO :474) (序列編號NO: 474) 實例56 pMON13185之建構使用述於「材料及方法」乙節中之方法I創造pMONl3 1 85 中之新N-端/C-端基因。使用引子組97 start (序列編號NO: 370)及 L-ll start (序列編號 NO: 364)，自 pMON13037 中之 G-CSF Ser17序列創造並擴增片段起點（Fragment Start)。使用引子組96 stop (序列編號NO: 371)及L-11 stop (序列編號 NO: 365)，自pMON13037中之G-CSF Ser17序列創造並擴增片段終點（Fragment Stop)。使用引子97 start及96 stop，自 O:\92\92747.DOC -290- 200413407 經黏連之片段起點及片段終點創造並擴增全長之新N-端 /C-端 G-CSF Ser17基因。以限制核酸内切酶Ncol及Hindlll切割處理含有新基因之所得DNA片段，並使用Magic DNA Clean-up Sustem套組 (Promega，Madison，WI)進行純化。以限制核酸内切酶 Hindlll及ΑΠΙΙΙ切割處理中間質體pMON13181 ，得到4068 鹼基對之載體片段，並使用Magic DNA Clean_up Sustem套組（Promega，Madison，WI)進行純化。結合經純化之限制片段，並使用 T4 DNA 聚合酶（Boehringer Mannheim, Indianapolis，IN)進行稼接。使用部分之稼接反應物轉形大腸桿菌菌株 DH5 α 細胞（Life Technologies，Gaithersburg， MD)。於含有胺苄青黴素之培養平板上篩選轉形株菌。分離質體DNA，並進行定序，以確認正確之插入。所得之質體稱為 PMON13185。以PMON13185轉形大腸桿菌菌株JM101，以進行蛋白質表現，並自包含體内分離蛋白。質體PMON13185含有（序列編號NO: 20)之DNA序列，其編碼下列胺基酸序列： O:\92\92747.DOC -291 - 200413407

Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg Pro Pro Ala Pro Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie Leu Arg Asn Leu Gin Pro Cys heu Prn Ser Ala Thr Ala Ala Pro Ser Arg His Pro lie lie 工 1c Lys Alai Gly Asp Trp Gin Glu Phe Arg Glu Ly3 Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala Asp Phe Ala Thr Thr Tie Trp Gin Gin Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser PhG Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro Ser Gly Gly Ser Gly Gly Ser Gin Scr Phe Leu Leu Lys Ser Leu Glu Gin Vdl Arg lie Gin Gly Asp Gly Alei Ala Leu Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie Ser (SEQ ID NO:475> (序列編號NO: 475) 實例57 pMON13186之建構使用述於「材料及方法」乙節中之方法I創造pMONl 3 186 中之新N-端/Ο端基因。使用引子組126 start (序列編號NO: 372)及 L-ll start (序列編號 NO: 364)，自 pMON13037 中之 G-CSF Ser17序列創造並擴增片段起點（Fragment Start)。使用引子組125 stop (序列編號NO: 371)及L-11 stop (序列編號NO: 365)，自pMON13037中之G-CSF Ser17序列創造並擴增片段終點（Fragment Stop)。使用引子126 start及125 stop ，自經黏連之片段起點及片段終點創造並擴增全長之新N-端/C-端 G-CSF Ser17基因。以限制核酸内切酶Ncol及Hindlll切割處理含有新基因之 O:\92\92747.DOC -292 - 200413407 所得DNA片段，並使用Magic DNA Clean-up System套組 (Promega，Madison，WI)進行純化。以限制核酸内切酶 Hindlll及Afllll切割處理中間質體pMON13180 ，得到4023 鹼基對之載體片段，並使用Magic DNA Clean-up System套組（Promega，Madison，WI)進行純化。結合經純化之限制片段，並使用 T4 DNA 聚合酶（Boehringer Mannheim， Indianapolis，IN)進行稼接。使用部分之稼接反應物轉形大腸桿菌菌株 DH5 α 細胞（Life Technologies，Gaithersburg, MD)。於含有胺芊青黴素之培養平板上篩選轉形株菌。分離質體DNA，並進行定序，以確認正確之插入。所得之質體稱為 PMON13186。以pMON13186轉形大腸桿菌菌株JM101，以進行蛋白質表現，並自包含體内分離蛋白。質體pMON13186含有（序列編號NO: 21)之DNA序列，其編碼下列胺基酸序列： O:\92\92747.DOC -293 - 200413407

Asn Cys Ser lie Met 工le Asp Glu Tie lie His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Άαη Asn Leu Asn Asp Glu Asp

Val Scr lie Leu Met: Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Sex: Phe Val Arg Ala Va]. r,ys Asn Leu Glu Asn Ala Ser Gly lie

Glxi Ala lie Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro lie lie 11¾ Lys Ala Gly Asp Trp

Gin Glu Phe Arg GHi Lys Leu Thr Ph^ Tyr Leu Val Thr Leu Glu

Gin Ala Gin Glu Gin Gin Ίγτ Val Glu Gly Gly Gly Gly Ser Pro

Gly Gly Gly Ser Gly Gly Gly Ser Asn Met Α1λ Met Ala Fro Ala

Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Phe

Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu G丄n Ser

Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Xi€tu Ala Gin Pro

Ser Gly Gly Gly Gly Ser Gin Ser Phe Leu Leu Lys Ser Leu

Glu Oln Val Arg Lys lie Gin Gly Asp Gly Ala Ala Leu Gin Glu

Lys Leu Cys Alci Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val

Leu Leu Gly His Ser Leu C5丄y lie Pro Trp Ala Pro Lieu Ser Ser

Qys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu

His Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Qlu

Gly lie Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu GJLn Leu

Asp Val Ala Asp Phe Ala Thr Thr lie Trp Gin Gin Met Glu Glu

Leu Gly (SEQ ID NO :476) (序列編號NO: 476) 實例58 pMON13187之建構使用述於「材料及方法」乙節中之方法I創造pMONl 3 186 中之新N-端/C-端基因。使用引子組126 start (序列編號NO: 372)及 L-ll start (序列編號NO: 364)，自 pMON13037 中之 G-CSF Ser 17序列創造並擴增片段起點（Fragment Start)。使用引子組125 stop (序列編號NO: 371)及L-11 stop (序列編號NO: 3 65)，自pMONl 3037中之G-CSF Ser 17序列創造並擴增片段終點（Fragment Stop)。使用引子126 start及125 stop ，自經黏連之片段起點及片段終點創造並擴增全長之新N-端/C-端 G-CSF Serl7基因。以限制核酸内切酶Ncol及Hindlll切割處理含有新基因之所得DNA片段，並使用Magic DNA Clean-up System套組 O:\92\92747.DOC -294- 200413407 (Promega，Madison，WI)進行純化。以限制核酸内切酶 Hindlll及Afllll切割處理中間質體pm〇N13181 ，得到4068 驗基對之載體片段，並使用Magic DNA Clean_up System套組（Promega, Madison，WI)進行純化。結合經純化之限制片段’並使用 T4 DNA 聚合酶（Boehringer Mannheim, Indianapolis, IN)進行稼接。使用部分之稼接反應物轉形大腸桿菌菌株 DH5 α 細胞（Life Technologies，Gaithersburg， MD)。於含有胺苄青黴素之培養平板上篩選轉形株菌。分離質體DNA，並進行定序，以確認正確之插入。所得之質體稱為 PMON13187。以pMON13187轉形大腸桿菌菌株JM101，以進行蛋白質表現’並自包含體内分離蛋白。質體PMON13187含有（序列編號NO: 22)之DNA序列，其編碼下列胺基酸序列：

Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser lie L»eu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Vai Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie

Glu Ala lie Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro lie lie He Lys Ala Cly Asp Trp

Gin Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gin Ala Gin Glu Gin Gin Tyr Val Glu Gly Gly Gly Gly Ser Pro

Gly Glu Pro Ser Gly Pro 工le Sex Thr 工le Asn Pro S^r Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Me匕 Ala Met Ala Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Phe

Gin Axg Arg Ala Cly Gly Val Leu Val Ala Scr His Leu Gin Ser

Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro

Ser Gly Gly Ser Gly Gly Ser Gin Ser Phe Leu Leu Lys Ser Leu

Glu Gin Val Arg Lys lie Gin Cly Asp Gly Ala Ala Leu Gin Glu

Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val

Leu Leu Gly His Ser Leu Gly lie Pio Trp Ala Pro Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Qln Lau His Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala Asp Phe Ala Thr Thr lie Trp Gin Gin Met Glu Glu Leu Gly (SEQ ID NO :477) O:\92\92747.DOC -295 - 200413407 (序列編號NO·· 477) 實例59 pMON13188之建構使用述於「材料及方法」乙節中之方法I創造pMONl 31 88 中之新N-端/C-端基因。使用引子組133 start (序列編號NO: 374)及 L-ll start (序列編號 NO: 364)，自 pMON13037 中之 G-CSF Ser17序列創造並擴增片段起點（Fragment Start)。使用引子組132 stop (序列編號NO: 375)及L-l 1 stop (序列編號NO·· 365)，自pMON13037中之G-CSF Ser17序列創造並擴增片段終點（Fragment Stop)。使用引子133 start及1 32 stop ，自經黏連之片段起點及片段終點創造並擴增全長之新N-端/C-端 G-CSF Set*17基因。以限制核酸内切酶Ncol及Hindlll切割處理含有新基因之所得DNA片段，並使用Magic DNA Clean-up System套組 (Promega，Madison，WI)進行純化。以限制核酸内切酶 Hindlll及Afllll切割處理中間質體pMON13180 ，得到4023 驗基對之載體片段，並使用Magic DNA Clean-up System套組（Promega，Madison，WI)進行純化。結合經純化之限制片段，並使用 T4 DNA 聚合酶（Boehringer Mannheim， Indianapolis，IN)進行稼接。使用部分之稼接反應物轉形大腸桿菌菌株 DH5 α 細胞（Life Technologies，Gaithersburg， MD)。於含有胺苄青黴素之培養平板上篩選轉形株菌。分離質體DNA，並進行定序，以確認正確之插入。所得之質體稱為 PMON13188。 O:\92\92747.DOC -296 - 200413407 以pMON13188轉形大腸桿菌菌株jmIOI，以進行蛋白質表現，並自包含體内分離蛋白。質體PMON13188含有（序列編號NO: 23)之DNA序列，其編碼下列胺基酸序列：

Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu bys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn ksn Leu Asn Asp Glu Asp

Val Ser 工le Leu Met: Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe yal Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie

Glu Ala lie Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro lie lie lie Lys Ala Gly Asp Trp

Gin Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gin Ala. Gin Glu Gin Gin Tyr Val Glu Cly Gly Gly Gly Ser Pro

Gly Gly Gly Ser Gly Gly Gly Ser Asn Met Ala. Thr Gin Gly Ala

Ket Pro Ala Phe Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly Val

Leu Val Ala. Ser His Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg

Val Leu Arg His Leu Ala Gin Pro »Ser Gly Gly Ser Gly Gly Ser

Gin Ser Phe Leu Leu Lys Ser Leu Glu Gin Val Arg Lys He Gin

Gly Asp Gly Ala Ala Leu Gin Glu Lys Leu Cys Ala Thr Tyr Lys

Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin

Leu Ala· Gly Cys Leu Ser Gin T：p.u His Ser Gly Leu Phe Leu Tyr

Gin Gly Leu Leu Gin Ala Leu Glu Gly lie Ser Pro Glu Leu Gly

Pro Thr Leu Asp Thx Leu Gin Leu Asp Val Ala Asp Phe Ala Thr

Thr lie Trp Gin Gin Met Θΐύ Glu Leu Gly Met Ala Pro Ala Leu

Gin Pro (SEQ ID NO:478} (序列編號NO: 478) 實例60 · pMON13189之建構使用述於「材料及方法」乙節中之方法I創造pMON 1 3 1 89 中之新N-端/C-端基因。使用引子組133 start (序列編號NO: 374)及 L_ll start (序列編號 NO: 364)，自 pMON13037 中之 G-CSF Ser17序列創造並擴增片段起點（Fragment Start)。使用引子組132 stop (序列編號NO: 375)及L-l 1 stop (序列編號NO: 3 65)，自pMON13037中之G-CSF Ser17序列創造並擴增片段終點（Fragment Stop)。使用引子133 start及132 stop O:\92\92747.DOC -297- 200413407 ，自經黏連之片段起點及片段終點創造並擴增全長之新N-端/C-端 G-CSF Ser17基因。以限制核酸内切酶Ncol及Hindlll切割處理含有新基因之所得DNA片段，並使用Magic DNA Clean-up System套組 (Promega，Madison，WI)進行純化。以限制核酸内切酶 Hindlll及Afllll切割處理中間質體pMON13181 ，得到4068 驗基對之載體片段’並使用Magic DNA Clean-up System套組（Promega，Madison，WI)進行純化。結合經純化之限制片段’並使用 T4 DNA 聚合酶（Boehringer Mannheim, Indianapolis, IN)進行稼接。使用部分之稼接反應物轉形大腸才千囷囷株 DH5 (2 細胞（Life Technologies，Gaithersburg， MD)。於含有胺苄青黴素之培養平板上篩選轉形株菌。分離質體DN A ’並進行定序’以確認正確之插入。所得之質體稱為 PMON13189。以PMON13189轉形大腸桿菌菌株JM101，以進行蛋白質表現，並自包含體内分離蛋白。質體PMON13189含有（序列編號NO: 24)之DNA序列，其編碼下列胺基酸序列：

Asn Cys Ser lie Met 工le Asp Glu lie lie His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Giu Asp

Val Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Cjlu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie

Glu Ala lie Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro lie lie lie Lys Ala Gly Asp Trp

Gin Glu Phe Arg Glu Ly$ Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gin Ala Gin Glu Gin Gin Tyr Val Glu Gly Gly Gly Gly Ser Pro O:\92\92747.DOC -298 - 200413407

Gly Glu Pro Ser Gly Pro He Ser Thr 工lc Asn Pro Ser Pro Pro

Ser L«ys Glu Ser His hys Ser Pro Asn MeU Ala Thr Gin G丄y Ala

Met Pro Ala Phe Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly Val

Leu Val Ala Ser His Leu G.ln Ser Phe Leu Glu Val Ser Tyr Arg

Val Leu Arg His Leu Ala Gin Pro Ser Gly Gly Ser Gly Gly Ser

Gin Ser Phe Leu Leu Lys Ser Leu Glu Gin Val Arg Lys lie Gin

Gly Asp Gly Ala. Ala Lexi Oln Glu Lys Leu Cys Ala Thr Tyr Lys

Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Sor Cys Pro Ser Gin Ala Leu Gin

Lqu Ala Gly Cys Leu Ser Gin Leu His Ser Gly Leu Phe Leu Tyr

Gin Gly Leu Leu Gin Ala Leu Glu Gly lie Ser Pro Glu Leu Gly

Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala Asp Phe Ala Thr

Thr 工le Trp Gin Gin Met: Glu Glu Leu Gly Met Ala Pro Ala_ Leu G丄n Pro <SKQ ID NO: 479 ) (序列編號NO: 479) 實例61 PMON13190之建構使用述於「材料及方法」乙節中之方法I創造pMONl 31 中之新N-端/C-端基因。使用引子組142 start (序列編號N〇: 376)及 L-ll start (序列編號 NO: 364)，自 pMON13037 中之 G-CSF Ser17序列創造並擴增片段起點（Fragment Start)。伏用引子組141 stop (序列編號NO: 377)及L-l 1 stop (序列編號NO: 365)，自pMON13037中之G-CSF Ser17序列創造旅擴增片段終點（Fragment Stop)。使用引子142 start及141 stop ’自經黏連之片段起點及片段終點創造並擴增全長之新N-端/C_端 G-CSF Ser17基因。以限制核酸内切酶Ncol及Hindlll切割處理含有新基因之所得DNA片段，並使用Magic DNA Clean-up System套雜 (Promega，Madison，WI)進行純化。以限制核酸内切_ Hindlll及Afllll切割處理中間質體PMON13180 ，得到4023 驗基對之載體片段，並使用Magic DNA Clean-up System套 200413407 組（Promega, Madison，WI)進行純化。結合經純化之限制片段，並使用 T4 DNA 聚合酶（Boehringer Mannheim， Indianapolis，IN)進行稼接。使用部分之稼接反應物轉形大腸桿菌菌株 DH5 α 細胞（Life Technologies，Gaithersburg， MD)。於含有胺苄青黴素之培養平板上篩選轉形株菌。分離質體DNA，並進行定序，以確認正確之插入。所得之質體稱為 pMON13190。以PMON13190轉形大腸桿菌菌株JM101，以進行蛋白質籲表現，並自包含體内分離蛋白。質體pMON13190含有（序列編號NO: 25)之DNA序列，其編碼下列胺基酸序列：

Asn Cys Ser He Met He Asp Glu lie lie Kis His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly Tie

Glu Ala lie Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro lie lie lie Lys Ala Gly Aap Trp

Gin Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gin Ala Gin Glu Gin Gin Tyr Val Glu Gly Gly Gly Gly Ser Pro

Gly Gly Gly Ser Gly Gly Gly^ Ser Asn Met Ala Ser Ala Phe Gin

Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser Phe

Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro Ser

Gly Gly Ser Gly Gly Ser Gin Ser Phe Leu Leu Lys Ser Leu Glu

Gin Val Arg Lys lie Gin Gly Asp Gly Al.a Ala Leu Gin Glu Lys

Leu Cys Ala Thr Tyr Lys Lou Cys His Pro Glu Glu Leu Val Leu

Leu Gly His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys

Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His

Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Lgu Glu Gly lie Ser Pro Glu Leu Gly Pro Tiir Leu Aap Thr Leu Gin Leu Asp

Val Ala Asp Phe Ala Thr Thr Tie Trp Gin Gin Met Glu Glu Leu

Gly Met: Ala. Pro Ala Leu Gin Pro Thr Cln Gly Ala Met Pro Ala

Phe Ala (SEQ ID NO :480) (序列編號NO: 480) 實例62 pMON13191之建構 O:\92\92747.DOC -300- 200413407 使用述於「材料及方法」乙節中之方法I創造pMONl 3 191 中之新N-端/C-端基因。使用引子組142 start (序列編號NO: 376)及 L-ll start (序列編號 NO: 364)，自 pMON13037 中之 G-CSF Seri7序列創造並擴增片段起點（Fragment Start)。使用引子組141 stop (序列編號NO: 377)及L-l 1 stop (序列編號NO: 365)，自pMON13037中之G-CSF Ser17序列創造並擴增片段終點（Fragment Stop)。使用引子142 st art及141 stop ，自經黏連之片段起點及片段終點創造並擴增全長之新N-端/C-端 G-CSF Ser17基因。以限制核酸内切酶Ncol及Hindlll切割處理含有新基因之所得DNA片段，並使用Magic DNA Clean-up System套組 (Promega，Madison，WI)進行純化。以限制核酸内切酶 Hindlll及Afllll切割處理中間質體pMON13181 ，得到4068 鹼基對之載體片段，並使用Magic DNA Clean-up System套組（Promega，Madison，WI)進行純化。結合經純化之限制片段，並使用 T4 DNA 聚合酶（Boehringer Mannheim， Indianapolis，IN)進行稼接。使用部分之稼接反應物轉形大腸桿菌菌株 DH5 α 細胞（Life Technologies，Gaithersburg， MD)。於含有胺苄青黴素之培養平板上篩選轉形株菌。分離質體DNA，並進行定序，以確認正確之插入。所得之質體稱為 PMON13191。以pMON13191轉形大腸桿菌菌株JM101，以進行蛋白質表現，並自包含體内分離蛋白。質體PMON13191含有（序列編號NO: 26)之DNA序列，其 O:\92\92747.DOC -301 - 200413407 編碼下列胺基酸序列：

Asn Cys Ser lie Met He Asp Glu 11¾ lie His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser lie Leu Met Asp Arg Ajsri Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Ala. Val Lys Asn Leu Glu Asn Ala Ser Gly lie

Glu Ala lie Leu Arg Asn Leu Girt Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro 工le lie 工le Lys Ala Gly Asp Trp

Gin Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gin Ala Gin Glu Gin Gin Tyr Val Glu Gly Gly Gly Gly S^r Pro

Gly Glu Pro Ser Gly Pro lie Ser Thr lie Asn Pro Ser Pro Pro

Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala ser Ala Piie Gin

Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser Phe

Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro Ser

Gly Gly Ser Gly Gly Ser Gin Ser Phe Leu Leu Lys Ser Leu Glu

Gin Val Arg Lys lie Gin Gly Asp Gly Ala Ala Gin C.lu Lys I；eu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu beu Val Leu

Leu Gly His Ser L白u Cily lie Pro Trp Ala Pro Leu Ser Ser cys

Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His

Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie Sor Pro Glu Leu Cly Pro Thr Leu Asp Thr Leu Gin Leu Asp

Val Ala Asp Phe Ala Thr Thr lie Trp Gin Gin itet: Glu Glu T*eu

Gly Met Ala Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala

Phe Ala <SEQ 工D NO:481) (序列編號NO: 481) 實例63 pMON13192之建構使用述於「材料及方法」乙節中之方法II創造pMONl3192 中之新N-端/Ο端基因。使用引子組39 start (序列編號NO: φ 368)及 P-bl start (序列編號 NO: 366)，自 ρΜΟΝ13037 中之 G-CSF序列創造並擴增片段起點（Fragment Start)。使用引子組 38 stop (序列編號NO: 369)及P-bl start stop (序列編號NO: 367)，自pMON13037中之G-CSF Ser17序列創造並擴增片段終點（Fragment Stop)。以限制核酸内切酶Ncol切割處理片段起點，並以限制核酸内切酶Hindlll切割處理片段終點。在純化之後，結合經切割處理之片段起點及終點，並稼接成為約3800鹼基對之Ncol-Hindlll載體片段pMON3934。 O:\92\92747.DOC -302 - 200413407 如上所述之中間質體含有全長之新N-端/C-端G-CSF Se;r17基因，且已經限制核酸内切酶Ncol及Hindlll切割處理。於1%之TAE凝膠上分離經切割之DNA，以溴化乙錠染色，並使用Geneclean (BiolOl，Vista，CA)純化該全長之新N-端/C-端G-CSF Ser17基因。以限制核酸内切酶Hindlll及Afllll 切割處理中間質體pMONl 3180 ，得到4023鹼基對之載體片段，並使用 Magic DNA Clean-up System 套組（Promega， Madison, WI)進行純化。結合經純化之限制片段，並使用 φ 丁4 DNA聚合酶（Boehringer Mannheim，Indianapolis，IN)進行稼接。使用部分之稼接反應物轉形大腸桿菌菌株DH5 α 細胞（Life Technologies，Gaithersburg，MD)。於含有胺爷青黴素之培養平板上篩選轉形株菌。分離質體DNA，並進行定序，以確認新基因之正確插入。所得之質體稱為 PMON13192。以PMON13192轉形大腸桿菌菌株JM101，以進行蛋白質表現，並自包含體内分離蛋白。籲質體PMON13192含有（序列編號NO: 27)之DNA序列，其編碼下列胺基酸序列： 13192.Pept

Asn Cys Ser Tie Met lie Asp Glu lie lie His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser lie Leu Met Asp Arcj Asn Lgu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly He

Glu Ala IXe Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro He lie lie Lys Ala Gly Asp Trp

Gin Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gin Ala Gin Glu Gin Gin Tyr Val Glu Gly Gly Gly Gly Ser Pro O:\92\92747.DOC - 303 - 200413407

Gly Gly Gly Ser Gly Gly Gly Ser Asn Met Ala Tyr Lys Leu Cys

His Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly lie Pro

Trp Ala Pro Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu Ala

Gly Cys Leu Ser Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly

Leu Leu Gin Ala Leu Glu Gly lie Ser Pro Glu Leu Gly Pro Thr

Leu Asp Thr Leu Gin Leu Asp Val Ala. Asp Phe Ala Tlu Thr lie

Trp Gin Gin Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gin Pro

Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gin Arg Arg

Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser Phe Leu Glu

Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro Thr Pro Leu

Gly Pro Ala Ser Ser Leu Pro Gin Ser Phe Leu Leu Lys Ser Leu

Glu Gin Arg Lys lie Gin Gly Asp Gly Ala Ala JLeTJ Gin Glu

Lys Leu Cys Ala Thr (SEQ ID NO:482} (序列編號NO: 482) 實例64 pMON13193之建構使用述於「材料及方法」乙節中之方法II創造pMONl 3 193 中之新N-端/C-端基因。使用引子組39 start (序列編號NO: 368)及 P-bl start (序列編號 NO: 366)，自 pMON13037 中之 G-CSF Ser17序列創造並擴增片段起點（Fragment Start)。使用引子組38 stop (序列編號NO: 369)及P_bl start stop (序列編號NO: 367)，自pMON13037中之G-CSF Ser17序列創造並擴增片段終點（Fragment Stop)。以限制核酸内切酶Ncol切割處理片段起點，並以限制核酸内切酶Hindlll切割處理片段終點。在純化之後，結合經切割處理之片段起點及終點，並稼接成為約3800鹼基對之Ncol-Hindlll載體片段 pMON3934 ° 如上所述之中間質體含有全長之新N-端/C-端G-CSF Ser17基因，且已經限制核酸内切酶Ncol及Hindlll切割處理。於1%之TAE凝膠上分離經切割之DNA，以溴化乙錠染色 O:\92\92747.DOC -304- 200413407 ，並使用Geneclean (BiolOl，Vista，CA)純化該全長之新N-端/C-端G-CSF Ser17基因。以限制核酸内切酶Hindlll及Afllll 切割處理中間質體pMON13 181 ，得到4068鹼基對之載體片段，並使用 Magic DNA Clean-up System 套組（Promega， Madison，WI)進行純化。結合經純化之限制片段，並使用 T4 DNA 聚合酶（Boehringer Mannheim，Indianapolis，IN)進行稼接。使用部分之稼接反應物轉形大腸桿菌菌株DH5 α 細胞（Life Technologies, Gaithersburg，MD)。於含有胺爷青黴素之培養平板上篩選轉形株菌。分離質體DNA，並進行定序，以確認新基因之正確插入。所得之質體稱為 pMON13193。以PMON13193轉形大腸桿菌菌株JM101，以進行蛋白質表現，並自包含體内分離蛋白。質體PMON13193含有（序列編號NO: 28)之DNA序列，其編碼下列胺基酸序列： O:\92\92747.DOC - 305 - 200413407

Asn Cys Ser 工le Met lie Asp Glu lie 工le His His Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie CHu Ala lie Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pr。、lie He lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Clu Lys Leu Thr Phe Tyr Lou Val Thr Leu Glu Gin Ala Gin Glu Gin Gin Tyr Val Glu Gly Gly Gly Gly 2er Pro Gly Glu Pro Ser Gly Pro lie Ser Thr Tie Asn Pro Pro Pro Scr Lys Glu Ser His Lys Ser Pro Asn Met Ala Tyr Lys Leu Cys His Pro Glu Glu Leu Vel Leu Leu Gly His Ser Leu Cly lie Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu Ala. Gly Cys Leu Ser Gin Leu His Ser Gly Le\i Phe t«eu Tyr Gin Gly Leu Leu Cln Ala Leu Glu Gly lie Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala Asp Phe Ala Thr Thr lie Trp Gin Gin Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His I.eu Ala Gin Pro Thr Pro Leu Gly Pro Ala. Ser Ser Leu Pro Gin Ser Phe Leu Leu Lys Ser Leu Glu Gin Val Arg Lys lie Gin Gly Asp Gly Ala Ala Leu Gin Glu Lys Leu Cys Ala Thr (SEQ ID NO :483) (序列編號NO: 483) 實例65 pMON25190之建構使用述於「材料及方法」乙節中之方法II創造pMON251 90 中之新N-端/C-端基因。使用引子組97 start (序列編號NO: 370)及P-bl start (序列編號NO: 366)，自 pMON13037 中之 G-CSF序列創造並擴增片段起點（Fragment Start)。使用引子組 96 stop (序列編號NO: 371)及P-bl start stop (序列編號NO: 367)，自pMON13037中之G-CSF Ser17序列創造並擴增片段終點（Fragment Stop)。以限制核酸内切酶Ncol切割處理片段起點，並以限制核酸内切酶Hindlll切割處理片段終點。在純化之後，結合經切割處理之片段起點及終點，並稼接成為約3800鹼基對之Ncol-Hindlll載體片段pMON3934。 O:\92\92747.DOC -306 - 200413407 如上所述之中間質體含有全長之新N-端/C-端G-CSF Ser17基因，且已經限制核酸内切酶Ncol及Hindlll切割處理。於1%之TAE凝膠上分離經切割之DNA，以溴化乙錠染色，並使用Geneclean (BiolOl，Vista, CA)純化該全長之新N-端/C-端G-CSF Ser17基因。以限制核酸内切酶Hindlll及Afllll 切割處理中間質體pMONl 3180 ，得到4023鹼基對之載體片段，並使用 Magic DNA Clean_up System 套組（Promega， Madison，WI)進行純化。結合經純化之限制片段，並使用丁4 DNA聚合酶（Boehringer Mannheim，Indianapolis，IN)進行稼接。使用部分之稼接反應物轉形大腸桿菌菌株DH5 a 細胞（Life Technologies，Gaithersburg，MD)。於含有胺爷青黴素之培養平板上篩選轉形株菌。分離質體DNA，並進行定序，以確認新基因之正確插入。所得之質體稱為 PMON25190。以PMON25190轉形大腸桿菌菌株JM101，以進行蛋白質表現，並自包含體内分離蛋白。質體PMON25190含有（序列編號NO: 29)之DNA序列，其編碼下列胺基酸序列： O:\92\92747.DOC - 307 - 200413407

Asn Cys Ser lie Met lie Asp Glu lie II« His His Leu Lys Arg

Pro Pro Alu Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg* Ala Lys Asn Leu Glu Asn Al^ Ser Gly 工丄e

Glu Aid lie Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro lie lie He Lys Ala Gly Asp Trp

Gin Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gin Ala Gin Glu Gin Gin Tyr Val Glu Gly Gly Gly Gly Ser Pro

Gly Gly Gly Ser Gly Gly Gly Ser Asn Met Ala Pro Glu Leu Gly

Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala Asp Phe Ala Thr

Thr lie Trp Gin Gin Met Glu Glu Leu Gly Met Ala Pro Ala Leu

Gin Pro Thr Gin Gly Ala M^t Pro Ala Phe Ala Ser Ala Phe Gin

Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser Phs L»eu Glu Val Ser Tyr Arg Val Leu Arg Hiss Leu Ala Gin Pro Thr

Pro T.eu Gly Pro Ala Ser Ser Leu Pro Gin Ser Ph^ Leu Leu Lys

Ser Leu Glu Gin Val Arg Lys 工le Gin Gly Asp Gly Ala Aisi Leu

Gin Glu Lys Leu Cys Ala Thr Tyr Lys T«eu Cys His Pro Glu Glu lieu Val Leu heu Gly His Ser Leu Gly lie Pro Trp Ala Px*o Leu

Ser Ser Cys I*ro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser

Gin Leu His Ser Gly Leu Phe Leu Ty^ Gin Gly Leu Leu Gin Ala

Leu Glu Gly lie Ser (SEQ ID NO:484) (序列編號NO: 484) 實例66 pMON25191之建構使用述於「材料及方法」乙節中之方法11創造PMON25190 中之新N-端/C-端基因。使用引子組97 start (序列編號NO: 370)及P-bl start (序列編號NO: 366)，自 pMON13037 中之 G-CSF Ser17序列創造並擴增片段起點（Fragment Start)。使用引子組96 stop (序列編號NO: 371)及P-bl start stop (序列編號NO: 367)，自pMON13037中之G-CSF Ser17序列創造並擴增片段終點（Fragment Stop)。以限制核酸内切酶Ncol切劉處理片段起點，並以限制核酸内切酶Hindlll切割處理片段終點。在純化之後，結合經切割處理之片段起點及終點’ 並稼接成為約3800鹼基對之Ncol-Hindlll載體片段 pMON3934 °

O:\92\92747.DOC - 308 - 200413407 如上所述之中間質體含有全長之新N-端/C-端G-CSF Ser17基因，且已經限制核酸内切酶Ncol及Hindlll切割處理。於1%之TAE凝膠上分離經切割之DNA，以溴化乙錠染色，並使用Geneclean (BiolOl，Vista，CA)純化該全長之新N-端/C-端G-CSF Ser17基因。以限制核酸内切酶Hindlll及Afllll 切割處理中間質體pMON13 181 ，得到4068鹼基對之載體片段，並使用 Magic DNA Clean-up System 套組（Promega， Madison，WI)進行純化。結合經純化之限制片段，並使用 φ Τ4 DNA聚合酶（Boehringer Mannheim，Indianapolis，IN)進行稼接。使用部分之稼接反應物轉形大腸桿菌菌株DH5 α 細胞（Life Technologies，Gaithersburg, MD)。於含有胺爷青黴素之培養平板上篩選轉形株菌。分離質體DNA，並進行定序，以確認新基因之正確插入。所得之質體稱為 PMON25191。以pMON25191轉形大腸桿菌菌株JM101，以進行蛋白質表現，並自包含體内分離蛋白。 _ 質體PMON25191含有（序列編號NO: 30)之DNA序列，其編碼下列胺基酸序列： O:\92\92747.DOC - 309 - 200413407

Asn Cys Ser 工le Met 工le Asp Glu lie lie His His Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Giu Asp Val Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro A^n L^u Glu Ser Phe Val Arg Ala Val Ly3 Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro lie Tl.e Tie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala Asp Phe Ala Thr Thr 工le Trp Gin Gin Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gin Arg Arg Ala G丄y Gly Val Leu Val Ala Ser His Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro Thr Pro Leu Gly Pro Ala Ser Ser L^u Pro Gin Ser Phe Leu Leu Lys Ser Leu Glu Gin Vai Arg Lys lie Gin Gly Asp Gly Ala Ala Leu Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly He Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gin Ma Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala. Leu Glu Gly lie Ser (SEQ ID MO :485) (序列編號NO·· 485) 實例67 pMON13194之建構使用述於「材料及方法」乙節中之方法11創造PM0N13194 中之新N-端/C-端基因。使用引子組126 start (序列編號NO: 372)及P-bl start (序列編號NO: 366)，自 pMON13037 中之鲁 G-CSF Ser17序列創造並擴增片段起點（Fragment Start)。使用引子組125 stop (序列編號NO: 371)及P-bl start stop (序列編號NO: 367)，自pMON13037中之G-CSF Ser17序列創造並擴增片段終點（Fragment Stop)。以限制核酸内切酶Ncol 切割處理片段起點，並以限制核酸内切酶Hindlll切割處理片段終點。在純化之後，結合經切割處理之片段起點及終點，並稼接成為約3800鹼基對之Ncol-Hindlll載體片段 pMON3934 ° O:\92\92747.DOC -310- 200413407 如上所述之中間質體含有全長之新N-端/C-端G-CSF Ser17基因，且已經限制核酸内切酶Ncol及Hindlll切割處理。於1%之TAE凝膠上分離經切割之DNA，以溴化乙鉸染色，並使用Geneclean (BiolOl，Vista，CA)純化該全長之新N-端/C-端G_CSF Ser17基因。以限制核酸内切酶Hindlll及Afllll 切割處理中間質體pMONl 3180 ，得到4023鹼基對之載體片段，並使用 Magic DNA Clean-up System 套組（Promega， Madison，WI)進行純化。結合經純化之限制片段，並使用 T4 DNA 聚合酶（Boehringer Mannheim，Indianapolis，IN)進行稼接。使用部分之稼接反應物轉形大腸桿菌菌株DH5 α 細胞（Life Technologies，Gaithersburg，MD)。於含有胺爷青黴素之培養平板上篩選轉形株菌。分離質體DNA，並進行定序，以確認新基因之正確插入。所得之質體稱為 PMON13194。以pMONl 3 194轉形大腸桿菌菌株JM101，以進行蛋白質表現，並自包含體内分離蛋白。質體pMON13194含有（序列編號NO: 31)之DNA序列，其編碼下列胺基酸序列：

Asn Cys Ser lie Met lie Asp Glu lie 工le His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie

Glu Ala Tie Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro lie Tie lie Lys Ala Gly Asp Trp

Gin Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gin Ala Gin Glu Gin Gin Tyr Val Glu Gly Gly Gly Gly Ser Pro

Gly Gly Gly Ser Gly Gly Gly Ser Asn Met Ala Ala Pro Ala

Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Phe

Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Sor

Phe Leu Glu Val Sf；r Tyr Arg Val Leu Arg His Leu Ala Gin Pro

Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser Phe Leu Leu O:\92\92747.DOC -311 - 200413407

Lys Ser Leu Glu Gin Val Arg Lys lie Gin Gly Asp Gly Ala

Leu Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu

Glu Leu Val Leu Leu Gly His Ser Leu Gly lie Pro Pr〇

Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu

Ser Gin Leu Kis Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin

Ala Leu Glu Gly He Ser Pro Glu Leu Gly Pro Thr T.^11 Asp Thr

Leu Gin Leu Asp Val Ala Asp Phe Ala Thr Thr He Trp Gin Gin

Met Glu Glu Leu Gly (SEQ ID NO:4S6) (序列編號NO: 486) 實例68 pMON13195之建構使用述於「材料及方法」乙節中之方法Π創造pMONl3195 中之新N-端/C-端基因。使用引子組126 start (序列編號NO: 372)及 P-bl start (序列編號 NO: 366)，自 pMON13037 中之 G-CSF Ser17序列創造並擴增片段起點（Fragment Start)。使用引子組125 stop (序列編號NO: 373)及P-bl start stop (序列編號NO: 367)，自pMON13037中之G-CSF Ser17序列創造並擴增片段終點（Fragment Stop)。以限制核酸内切酶Ncol 切割處理片段起點，並以限制核酸内切酶Hindlll切割處理片段終點。在純化之後，結合經切割處理之片段起點及終點，並稼接成為約3800鹼基對之Ncol-Hindlll載體片段 PMON3934 ° 如上所述之中間質體含有全長之新N-端/C-端G-CSF Ser17基因，且已經限制核酸内切酶Ncol及Hindlll切割處理。於1%之TAE凝膠上分離經切割之DNA，以溴化乙錠染色，並使用Geneclean (BiolOl，Vista，CA)純化該全長之新N-端/C-端G-CSF Ser17基因。以限制核酸内切酶Hindlll及Afllll O:\92\92747.DOC -312- 200413407 切割處理中間質體pMON13 181 ，得到4068鹼基對之載體片段，並使用 Magic DNA Clean-up System 套組（Promega， Madison，WI)進行純化。結合經純化之限制片段，並使用 T4 DNA聚合酶（Boehringer Mannheim，Indianapolis，IN)進行稼接。使用部分之稼接反應物轉形大腸桿菌菌株DH5 α 細胞（Life Technologies，Gaithersburg，MD)。於含有胺字青黴素之培養平板上篩選轉形株菌。分離質體DNA，並進行定序，以確認新基因之正確插入。所得之質體稱為 pMON13195。以PMON13195轉形大腸桿菌菌株JM101，以進行蛋白質表現，並自包含體内分離蛋白。質體PMON13195含有（序列編號NO·· 32)之DNA序列，其編碼下列胺基酸序列：

Asn Cys Ser lie Met lie Asp Glu llq 工le His His I.eu Lys Axy Pro Pro Ala Pro Leu Leu Asp Pro A_sn Leu Asn Asp Glu Asp Val Scr lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Scr Arg His Pro Xle 工le lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val T"h.r T»e.u Glu Oln Ala. Gin Glu Gin Gin Tyir Val Gl*u Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie Sor Thr 工le Asn Pro Ser Pro Pro Ser Lys Glu Ser H.is Lys Ser Pro Asn Met Ala Met Ala Pro Ala Leu Gin Pro Thr Gin Gly Al^ Met Pro Ala Phe Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly Val Leu Va.1 Alei Ser His Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His T^eu Ala Gin Pro Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser Phe L^u Leu Lys Ser Leu Glu Gin Val Arg Lys lie Gin Gly Asp Gly Ala Ala Lgu Gin Glu Lys Leu Cys Ala Thx Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser Gly Leu Phe Len Tyr Gin Gly Γ-eu Leu Gin Alci Leu Glu Gly lie Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala Asp Phe Ala Thr Thr lie Trp Gin Gin Met: Glu Glu Leu Gly (SEQ ID N〇：487) (序列編號NO: 487) O:\92\92747.DOC -313 - 200413407 實例69 PMON13196之建構使用述於「材料及方法」乙節中之方法II創造pMONl 3 196 中之新N-端/C-端基因。使用引子組133 start (序列編號NO: 374)及 P-bl start (序列編號 NO: 366)，自 PMON13037 中之 G-CSF Ser17序列創造並擴增片段起點（Fragment Start)。使用引子組132 stop (序列編號NO: 375)及P_bl start stop (序列編號NO: 367)，自pMON13037中之G-CSF Ser17序列創造 · 並擴增片段終點（Fragment Stop)。以限制核故内切酶Ncol 切割處理片段起點，並以限制核酸内切酶Hindlll切割處理片段終點。在純化之後，結合經切割處理之片段起點及終點，並稼接成為約3800鹼基對之Ncol-Hindlll載體片段 pMON3934 ° 如上所述之中間質體含有全長之新N-端/C-端G_CSF Ser17基因，且已經限制核酸内切酶Ncol及Hindlll切割處理。於1%之TAE凝膠上分離經切割之DNA，以溴化乙錠染色修，並使用Geneclean (BiolOl，Vista，CA)純化該全長之新N-端/C-端G-CSF Ser17基因。以限制核酸内切酶Hindlll及ΑίΊΙΙΙ 切割處理中間質體pMONl3180 ，得到4023鹼基對之載體片段，並使用 Magic DNA Clean-up System 套組（Promega， Madison，WI)進行純化。結合經純化之限制片段，並使用 T4 DNA聚合酶（Boehringer Mannheim，Indianapolis，IN)進行稼接。使用部分之稼接反應物轉形大腸桿菌菌株DH5 α 細胞（Life Technologies，Gaithersburg，MD)。於含有胺；青 O:\92\92747.DOC -314- 200413407 黴素之培養平板上篩選轉形株菌。分離質體DNA，並進行定序，以確認新基因之正確插入。所得之質體稱為 pMON13196。以PMON13196轉形大腸桿菌菌株JM101，以進行蛋白質表現，並自包含體内分離蛋白。質體pMON13196含有（序列編號NO: 33)之DNA序列，其編碼下列胺基酸序列：

Asn Cys Ser 工le Het lie Asp Giu lie lie His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Giu Asp

Val Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Giu

Ser Phe Val Arg Ala. Val Lys Asn Leu Giu Asn Ala Ser Gly lie

Giu Ala lie Leu Arg Asn Leu Gin Pro Cy3 Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arcj His Pro lie lie lie Lys A丄a G丄y Asp Trp

Gin Giu Phe Arg Giu Lys Leu Thr Phe Tyr Leu Val Thr Leu Giu

Gin Ala Gin Giu Gin Gin Tyr Val Giu Gly Gly Gly Gly Ser Pro GLy GLy Gly Ser Gly Gly Gly Ser Asn Met Ala Thr Gin G_Ly A丄a

Met Pro Ala Phe Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly Val

Leu Val Ala Ser His Leu Gin Ser Phe Leu Giu Val Ser Tyr Arg

Val Leu Arg His Leu Ala Gin Pro Thr Pro Leu Gly Pro Ala Ser

Ser Leu Pro Gin Ser Phe Leu Leu Lys Ser Leu Giu Gin Val Arg

Lys lie Gin Gly Asp Gly Ala Ala Leu Gin Giu Lys Leu Cys Ala

Thr Tyr Lys Leu Cys His Pro Giu Giu Leu Val Leu Leu Gly His

Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gin

Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu Hi3 Ser Gly Leu

Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Giu Gly lie Ser Pro

Giu Leu Gly Pro Thx* Leu Asp Thr Leu Gin Leu Asp Val Ala Asp

Phe Ala Thr Thr lie Trp Gin Gin Met Giu Giu Leu Gly Met Ala

Pro Ala Leu Gin Pro (SEQ ID NO; 488) (序列編號NO: 488) 實例70 pMON13197之建構使用述於「材料及方法」乙節中之方法11創造PMON13 197 中之新N-端/C-端基因。使用引子組133 start (序列編號NO: 374)及 P-bl start (序列編號 NO: 366)，自 pMON13037 中之 G_CSF Ser17序列創造並擴增片段起點（Fragment Start)。使

O:\92\92747.DOC -315- 200413407 用引子組132 stop (序列編號NO: 375)及P-bl start stop (序列編號NO: 367)，自pMON13037中之G-CSF Ser17序列創造並擴增片段終點（Fragment Stop)。以限制核酸内切酶Ncol 切割處理片段起點，並以限制核酸内切酶Hindlll切割處理片段終點。在純化之後，結合經切割處理之片段起點及終點，並稼接成為約3800鹼基對之Ncol-Hindlll載體片段 PMON3934 〇如上所述之中間質體含有全長之新N-端/C-端G-CSF φ Ser17基因，且已經限制核酸内切酶Ncol及Hindlll切割處理。於1%之TAE凝膠上分離經切割之DNA，以溴化乙錠染色，並使用Geneclean (BiolOl，Vista，CA)純化該全長之新N-端/C-端G-CSF Ser17基因。以限制核酸内切酶Hindlll及Afllll 切割處理中間質體pMON13 181 ，得到4068鹼基對之載體片段，並使用 Magic DNA Clean-up System 套組（Promega， Madison，WI)進行純化。結合經純化之限制片段，並使用 T4 DNA聚合酶（Boehringer Mannheim，Indianapolis，IN)進鲁行稼接。使用部分之稼接反應物轉形大腸桿菌菌株DH5 α 細胞（Life Technologies，Gaithersburg，MD)。於含有胺爷青黴素之培養平板上篩選轉形株菌。分離質體DNA，並進行定序，以確認新基因之正確插入。所得之質體稱為 pMON13197。以pM〇N13 197轉形大腸桿菌菌株JM101，以進行蛋白質表現，並自包含體内分離蛋白。質體PMON13197含有（序列編號NO: 34)之DNA序歹!J，其 O:\92\92747.DOC -316- 200413407 編碼下列胺基酸序列：

Asn Cys Ser Tie Met lie Asp Glu lie lie His His Leu Lys Arg

Pro Pro Ala Pro L«u Leu Asp Pro Asn Asn Leu Asr； Asp Glu Asp

Va丄 Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie

Glu Ala lie Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro He lie 11^ Lys Ala Gly Asp Trp

Gin Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gin Ala Qln Glu Gin Gin Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Gly Gly Ssr Giy Gly Gly Ser Asn Met Ala Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin hew Ala Gly Cys Leu Ser Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Aia Leu Glu Gly lie Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val A]a Asp Phe Ala Thr Thr lie Trp Qln Gin Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly Val Leu Val A.la Ser His I.eu Gin Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser Phe Leu Leu Lys Ser Leu Glu Gin Val Arg liys lie Gin Gly Asp Gly Ala Ala Leu Gin Glu Lys Leu Cy^ Al^ Thr (SEQ ID NO:489) (序列編號NO: 489) 實例71 pMON13198之建構使用述於「材料及方法」乙節中之方法II創造pMONl3 198 中之新N-端/C-端基因。使用引子組142 start (序列編號NO: 376)及 P-bl start (序列編號 NO: 366)，自 pMON13037 中之 G-CSF Ser17序列創造並擴增片段起點（Fragment Start)。使用引子組141 stop (序列編號NO: 377)及P-bl start stop (序列編號NO: 367)，自pMON13037中之G-CSF Ser17序列創造並擴增片段終點（Fragment Stop)。以限制核酸内切酶Ncol 切割處理片段起點，並以限制核酸内切酶Hindlll切割處理片段終點。在純化之後，結合經切割處理之片段起點及終點，並稼接成為約3800鹼基對之Ncol-Hindlll載體片段 O:\92\92747.DOC -317- 200413407 pMON3934 ° 如上所述之中間質體含有全長之新N-端/C-端G-CSF Ser17基因，且已經限制核酸内切酶Ncol及Hindlll切割處理。於1%之TAE凝膠上分離經切割之DNA，以溴化乙錠染色，並使用Geneclean (BiolOl，Vista，CA)純化該全長之新N-端/C-端G-CSF Ser17基因。以限制核酸内切酶Hindlll及Afllll 切割處理中間質體pMONl 3180 ，得到4023鹼基對之載體片段，並使用 Magic DNA Clean-up System 套組（Promega， Madison，WI)進行純化。結合經純化之限制片段，並使用 T4 DNA聚合酶（Boehringer Mannheim，Indianapolis，IN)進行稼接。使用部分之稼接反應物轉形大腸桿菌菌株DH5 α 細胞（Life Technologies，Gaithersburg，MD)。於含有胺爷青黴素之培養平板上篩選轉形株菌。分離質體DNA，並進行定序，以確認新基因之正確插入。所得之質體稱為 pMON13198。以PMON13198轉形大腸桿菌菌株JM101，以進行蛋白質表現，並自包含體内分離蛋白。質體PMON13198含有（序列編號NO: 35)之DNA序列，其編碼下列胺基酸序列： O:\92\92747.DOC -318- 200413407

Asn Cys Ser 工le Met lie Asp Glu lie lie His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser lie Leu Met Asp Arg Asn Leu Arg lieu Pro A^n Leu Glu

Sei: Phe Val Arg Ala Val Lys Asn L^u Glu Asn Ala Ser Gly lie

Glu Ala lie Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg Kis Pro 工le lie Tie Lys Ala Gly Asp Trp

Gin Glu Phe Arg Glu hys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gin Ala Gin Glu Gin Gin Tyr Val Glu Gly Gly Gly Gly Ser Pro

Gly Gly Gly Ser Gly Gly Gly Ser Asn Met A丄a Ser Ala Phe Gin

Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser Phe

Lgu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro Thr

Pro Leu Gly Pro Ala S纪;r Ser Leu Pro d丄n Ser Phe Leu Leu Lys

Ser Leu Glu Gin Val Arg Lys lie Gin Gly Asp Gly Ala Ala Leu

Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro <31u Clu

Leu Val Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala Pro Leu

Ser Ser Cys Pro Ser Gin Ala T.eu Gin Leu Ala Gly Cys Leu Ser

Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala

Leu Glu Gly lie Ser Pro Glu Leu Gly Pro Thr Leu Asp Thi' Leu

Gin Leu Asp Val Ala Asp Phe Ala Thr Thr lie Trp Gin Gin Met

Glu Glu Leu Gly Met Ala Pro Ala Leu Gin Pro Thr Gin Gly Ala

Met Pro Ala Phe Ala (SEQ ID NO:490) (序列編號NO: 490) 實例72 pMON13199之建構使用述於「材料及方法」乙節中之方法II創造pMONl 3199 中之新N-端/C-端基因。使用引子組142 start (序列編號NO: 376)及P-bl start (序列編號NO: 366)，自 pMON13037 中之 G-CSF Ser17序列創造並擴增片段起點（Fragment Start)。使用引子組141 stop (序列編號NO: 377)及P-bl start stop (序列編號NO: 367)，自pMON13037中之G-CSF Ser17序列創造並擴增片段終點（Fragment Stop)。以限制核酸内切酶Ncol 切割處理片段起點，並以限制核酸内切酶Hindlll切割處理片段終點。在純化之後，結合經切割處理之片段起點及終點，並稼接成為約3800鹼基對之Ncol-Hindlll載體片段 pMON3934 °

如上所述之中間質體含有全長之新N-端/C-端G-CSF O:\92\92747.DOC -319- 200413407

Ser17基因，且已經限制核酸内切酶Ncol及Hindlll切割處理。於1%之TAE凝膠上分離經切割之DNA，以溴化乙錠染色，並使用Geneclean (BiolOl，Vista，CA)純化該全長之新N· 端/C-端G-CSF Ser17基因。以限制核酸内切酶Hindlll及 Afllll切割處理中間質體pMON13181 ，得到4068鹼基對之載體片段，並使用Magic DNA Clean-up System套組 (Promega，Madison，WI)進行純化。結合經純化之限制片段，並使用 T4 DNA聚合酶（Boehringer Mannheim，Indianapolis， IN)進行稼接。使用部分之稼接反應物轉形大腸桿菌菌株 DH5a 細胞（Life Technologies，Gaithersburg，MD)。於含有胺苄青黴素之培養平板上篩選轉形株菌。分離質體DNA，並進行定序，以確認新基因之正確插入。所得之質體稱為 pMON13199。以PMON13199轉形大腸桿菌菌株JM101，以進行蛋白質表現，並自包含體内分離蛋白。質體PMON13199含有（序列編號NO: 36)之DNA序列，其編碼下列胺基酸序列： O:\92\92747.DOC -320 - 200413407

As:i Cys Ser lie Met 工le Asp Glu lie lie His His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie

Glu Ala lie Lqu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr

Ala Ala Pro Ser Arg His Pro Tie lie lie Lys Ala Gly Asp Trp

Gin Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu

Gin Ala Gin Glu Gin Gin Tyr Val Giu Gly Gly Gly Gly Ser Pro

Gly Glu Pro Ser Gly Pro He Ser Thr lie Asn Pro Ser Pro Pro

Ser Lys Glu Ser His Lys Ser Pro Asn Mot Ala Ser Ala Phe Gin

Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser Phe

Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro Thr

Pro Leu Gly Pro Ala Sex Ser Leu Pro Gin Ser Phe Leu Leu Lys

Ser Leu Glu Gin Val Arg Lys lie Gin Gly Asp Gly Ala Ala Leu

Gin Glu Lys Leu Cys 八la Thr Tyr Lys Leu Cys His Pro Glu Glu

Leu Val· Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala Pro Leu

Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser

Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala

Leu Glu Gly lie Ser Pro Gill Leu Gly Σ’γο Thr Leu Asp Thr Leu

Gin Leu Asp Val, Ala Asp Phe Ala Thr Thr lie Trp Gin Gin Met

Glu Glu Leu Gly Met Ala Pro Ala Leu Gin Pro Thr Gin Gly Ala

Met Pro Ala Phe Ala (SEQ ID NO :491} (序列編號NO: 491) 實例73 串聯重複性質體樣板Sy n tan 1之建構為建構串聯重複性之hIL-3受體促效劑pMON13416樣板 Syntanl，使用 T4 DNA聚合酶（Boehringer Mannheim)，稼接連結三段DNAs。此三段DNAs為：1)經BstEII及SnaBI切割 · 處理之PMON13046，其含有hIL-3受體促效劑pMON13416 ;2)經黏連之合成寡核嘗酸互補對Llsyn.for (序列編號NO: 3 52)及1^13乂11^¥(序列編號1^0:3 53)，其含有編碼連接原始蛋白C-端及N-端之連接子之序列，以及少量之週邊 pMONl3416序列，且此兩合成寡核苷酸互補對已經恰當組裝而產生BstEII及Clal端；及3) hIL-3受體促效劑 pM〇N13416之部分，其係以ClaI(DNA培養於dam-細胞DMl (Life Technologies)中）及 SnaBI 自 pMONl 3046切下。於 0.9% O:\92\92747.DOC -321 - 200413407 之TAE凝膠上分離經切割之DNAs，以溴化乙錠染色，並使用 Geneclean (BiolOl)分離。使用部分之稼接反應物轉形大腸桿菌菌株DH5 α細胞 (Life Technologies，Gaithersburg，MD)。將微製備之DNA 自轉形株中分離，並使用基於PCR之分析篩選轉形株。對取自經篩選轉形株中之質體DNA進行定序，以取得正確之樣板。所得之質體稱微syntanl，且其含有（序列編號NO: 7)之 DNA序列。實例74 串聯重複性樣板syntan3之建構為建構串聯重複性之hIL-3受體促效劑樣板syntan3，使用 T4 DNA聚合酶（Boehringer Mannheim)，稼接連結三段 DNAs 。此三段DNAs為：1)經BstEII及SnaBI切割處理之 pMON13 046，其含有hIL-3受體促效劑pMON13416 ; 2)經黏連之合成寡核甞酸互補對L3syn.for (序列編號NO: 354)及 L3syn.rev (序列編號NO: 355)，其含有編碼連接原始蛋白C-端及N-端之連接子之序列，以及少量之週邊pMON13416序列，且此兩合成寡核苷酸互補對已經恰當組裝而產生BstEII 及SnaBI端；及3) hIL-3受體促效劑pM〇N13416之部分，其係以 Clal (DNA培養於 dam-細胞 DM 1 (Life Technologies)中）及SnaBI自pMONl 3 046切下。於0.9%之TAE凝膠上分離經切割之DNAs，以溴化乙鍵染色，並使用Geneclean (Bio 101) 分離。使用部分之稼接反應物轉形大腸桿菌菌株DH5 α細胞 O:\92\92747.DOC -322- 200413407 (Life Technologies，Gaithersburg, MD)。將微製備之DNA 自轉形株中分離，並使用基於PCR之分析篩選轉形株。對取自經篩選轉形株中之質體DNA進行定序，以取得正確之樣板。所得之質體稱微syntan3，且其含有（序列編號NO: 8)之 DNA序列。實例75 pMON31104之建構使用述於「材料及方法」乙節中之方法III創造 pMON3 11 04中之新N-端/C-端基因。使用引子組35 start (序列編號NO: 356)及34 rev (序列編號NO: 357)，自中間質體 Syntanl創造並擴增全長之新N-端/C-端liIL_3受體促效劑 pMON13416基因。以限制核酸内切酶Ncol及SnaBI切割處理含有新基因之所得片段。於1%之TAE凝膠上分離經切割之DNA，以溴化乙錠染色，並使用Geneclean (BiolOl，Vista，CA)分離。使用 T4 DNA聚合酶（Boehringer Mannheim，Indianapolis，IN) ，使純化之經切割DNA片段稼接進入表現載體pMONl3189 中。該pMON13189 DNA已先經Ncol及SnaBI切割，以除去 hIL-3受體促效劑pMONl 3416編碼序列，且該4254鹼基對之載體片段係在於0.8%之TAE凝膠上分離，並以溴化乙錠染色後，使用Geneclean (BiolOl，Vista，CA)分離。使用部分之稼接反應物轉形大腸桿菌菌株DH5 α細胞（Life Technologies, Gaithersburg，MD)。於含有胺字青黴素之培養平板上篩選轉形株菌。分離質體DNA，並進行定序，以 O:\92\92747.DOC - 323 - 200413407 確認正確之插入。所得之質體稱為pM〇N311〇4。以PMON31104轉形大腸桿菌菌株JM1〇1，以進行蛋白質表現，並自包含體内分離蛋白。質體pMON3 1104含有（序列編號NO: 9)之DNA序列，其編碼下列胺基酸序列：

Leu Asp Pro Asn Asri Leu Asn Asp Glu Asp ，\7a丄 Ser ΙΙβΕθιίαΜβΙ

Asp Arg Asn Leu Arg Leu Pro Asa Leu Glu Ser Phe Val Arg Ala

Val I.ys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie Leu Arg

Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg

His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phc Arg Glu

Lys Tieu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin

Gin Gly Gly Gly Ser Asn Cys Ser I] e Met:工le Asp Glu 工 1¾ lie

His His Leu Lys Arg Pro Pro Ala Pro Leu Tyr Val Glu Gly Gly

Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie Ser Thr lie Asn

Pro Sor Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala

Thr Gin Gly Ala Met. Pro Pine Ala Ser Ala Phe Gin Arg Arg

Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser Phe Leu Glu

Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro Ser Gly Gly

Ser Gly Gly Ser Gin Ser Phe Leu L^u Lys Ser Leu Glu Gin Val

Arg Lys lie Gin Gly Asp Gly Ala Ala Leu Gin Glu Lya Leu Cys

Ala Thr Tyr Lys L<du Cya His Pro Glu Glu Leu Val Leu Leu Gly

His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser

Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser Giy

Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie Ser

Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala

Asp Phe Ala Thr Thr lie Trp Gin Gin M^t Glu Glu L^u Gly Met

Ala Pro Ala Leu Gin Pro (SEQ ID MO :492) (序列編號NO: 492) 實例76 pMON31105之建構使用述於「材料及方法」乙節中之方法III創造 pMON3 1105中之新N-端/C-端基因。使用引子組70 start (序列編號NO: 3 58)及69 rev (序列編號NO: 359)，自中間質體 Syntanl創造並擴增全長之新N-端/C-端hIL-3受體促效劑 pM〇N13416基因。 O:\92\92747.DOC -324- 200413407 以限制核酸内切酶Ncol及SnaBI切割處理含有新基因之所得片段。於1%之TAE凝膠上分離經切割之DNA，以溴化乙錠染色，並使用Gene clean (Bio 1 01，Vista，CA)分離。使用 T4 DNA聚合酶（Boehringer Mannheim，Indianapolis，IN) ，使純化之經切割DNA片段稼接進入表現載體pMONl 3 189 中。該pMON13189 DNA已先經Ncol及SnaBI切割，以除去 hIL-3受體促效劑pMONl 3416編碼序列，且該4254鹼基對之載體片段係在於0.8%之TAE凝膠上分離，並以溴化乙錠染色後，使用Geneclean (BiolOl，Vista，CA)分離。使用部分之稼接反應物轉形大腸桿菌菌株DH5 α細胞（Life Technologies，Gaithersburg，MD)。於含有胺爷青黴素之培養平板上篩選轉形株菌。分離質體DNA，並進行定序，以確認正確之插入。所得之質體稱為pMON31105。以PMON31105轉形大腸桿菌菌株JM101，以進行蛋白質表現，並自包含體内分離蛋白。質體PMON31105含有（序列編號NO: 10)之DNA序列，其編碼下列胺基酸序列： O:\92\92747.DOC - 325 - 200413407

Asn Ala Ser Gly lie Clu Ala lie Leu Arg Asn Leu Gin Pro Cys L^u Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro lie lie lie

Lys Ala Gly Asp Trp Gin Glu Pine Arg Glu Lys Leu Thr Phe Tyr

Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin Gly Gly Gly Ser

Asn Cys Ser lie Met 工le Asp Glu lie lie H丄s His Leu Lys Arg

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp

Val Ser 工le Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu

Ser Ph.e Val Arg Ala Val Lys Asn Leu Glu Tyr Val Glu Gly Gly

Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie Ser Thr lie Asn

Pro Ser Pro Pro Scr Lys Glu Ser His Lys Ser Pro Asn Met Ala

Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gin Arg Arg

Ala Gly Gly Val Leu Val Ala Ser His Lqu Gin Ser Phe Leu Glu

Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro Ser Gly Gly

Ser Gly Gly Ser Gin Ser Phe Leu Leu Lys Ser Leu Glu Gin Val

Arg Lys lie Gin Gly Asp Gly Ala Ala Leu Gin Glu Lys Leu Cys

Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly

His Ser Leu Giy lie Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser

Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser Gly

Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly 工le Ser

Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala

Asp Phe Ala Thr Thr lie Trp Gin Gin Met Glu Glu Leu Gly Met

Ala Pro Ala Leu Gin Pro (SEQ ID NO :4935 (序列編號NO: 493) 實例77 pMON31106之建構使用述於「材料及方法」乙節中之方法III創造 pMON31106中之新N-端/C-端基因。使用引子組91 start (序列編號NO: 360)及90 rev (序列編號NO·· 361)，自中間質體 Syntanl創造並擴增全長之新N-端/C-端hIL-3受體促效劑 pMON13416基因。以限制核酸内切酶Ncol及SnaBI切割處理含有新基因之所得片段。於1%之TAE凝膠上分離經切割之DNA，以溴化乙錠染色，並使用Gene clean (Bio 101，Vista，CA)分離。使用 T4 DNA聚合酶（Boehringer Mannheim，Indianapolis，IN) ，使純化之經切割DNA片段稼接進入表現載體pMONl3 189 中。該pMON13189 DNA已先經Ncol及SnaBI切割，以除去 O:\92\92747.DOC - 326 - 200413407 hIL-3受體促效劑pMON13416編碼序列，且該4254鹼基對之載體片段係在於0.8%之TAE凝膠上分離，並以溴化乙錠染色後，使用Geneclean (BiolOl，Vista，CA)分離。使用部分之稼接反應物轉形大腸桿菌菌株DH5 α細胞（Life Technologies，Gaithersburg，MD)。於含有胺芊青黴素之培養平板上篩選轉形株菌。分離質體DNA，並進行定序，以確認正確之插入。所得之質體稱為pMON3 11 06。以PMON31106轉形大腸桿菌菌株JM101，以進行蛋白質表現，並自包含體内分離蛋白。質體PMON31106含有（序列編號NO·· 11)之DNA序列，其編碼下列胺基酸序列··

Ala Pro Ser Arg His Pro lie lie He Lys Ala Gly Asp Trp Gin

Glu Phe Arg Glu Lys Leu Thr Pile Tyr Leu Val Thr Leu Glu Gin

Ala Gin Glu Gin Gin Gly Gly Gly Ser Asn Cys Ser He Met lie

Asp Glu lie lie His His Leu Lys Arg Pro Pro Ala Pro Leu Leu

Asp Pro Asn Asn Leu Asn Asp. Glu Asp Val Ser lie Leu Met Asp

Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arq Ala Val

Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie Leu Arg Asn

Lgu Gin Pro Cys Leu Pro Ser Ala Thr Ala Tyr Val Glu Gly Gly

Gly Giy Ser Pro Gly Glu Pro Ser Gly Pro lie Ser Thr lie Asn

Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala

Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gin Arg Arg

Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser Phe Leu Glu

Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro Ser Gly Gly

Ser Gly Gly Ser Gin Ser Phe Leu Leu Lys Ser Leu Glu Gin Val

Arg Lys lie Gin Gly Asp Gly Ala Ala Leu Gin Glu Lys Leu Cys

Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly

His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser

Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Lgu His Ser Gly

Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie Ser

Pro Glu Leu Gly Pro Thr Leu Asp Thi： Leu Gin LfiU Asp Val Ala

Asp Phe Ala Thr Thr lie Trp Gin Gin Met: Glu Glu lieu Gly Met Ala Pro Ala Leu Gin Pro (SEQ ID (序列編號NO: 494) 實例78 pMON31107之建構 O:\92\92747.DOC -327- 200413407 使用述於「材料及方法」乙節中之方法III創造 pMON3 1107中之新N-端/C-端基因。使用引子組101 start ( 序列編號NO·· 362)及100 rev (序列編號NO: 363)，自中間質體Syntanl創造並擴增全長之新N-端/C-端hIL-3受體促效劑 pMON13416基因。以限制核酸内切酶Ncol及SnaBI切割處理含有新基因之所得片段。於1%之TAE凝膠上分離經切割之DNA，以溴化乙錠染色，並使用Geneclean (BiolOl，Vista，CA)分離。使鲁用 T4 DNA聚合酶（Boehringer Mannheim，Indianapolis，IN) ，使純化之經切割DNA片段稼接進入表現載體pMONl3 189 中。該pMON13189 DNA已先經Ncol及SnaBI切割，以除去 hIL-3受體促效劑pMON13416編碼序列，且該4254鹼基對之載體片段係在於0.8%之TAE凝膠上分離，並以溴化乙錠染色後，使用Geneclean (BiolOl，Vista，CA)分離。使用部分之稼接反應物轉形大腸桿菌菌株DH5 α細胞（Life Technologies，Gaithersburg，MD)。於含有胺爷青黴素之培 _ 養平板上篩選轉形株菌。分離質體DN A，並進行定序，以確認正確之插入。所得之質體稱為pMON3 1107。以pMON31107轉形大腸桿菌菌株JM101，以進行蛋白質表現，並自包含體内分離蛋白。質體PMON31107含有（序列編號NO: 12)之DNA序歹|J，其編碼下列胺基酸序列： O:\92\92747.DOC - 328 - 200413407 (i) 序列特性： (A) 長度：281胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO.· 579

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30

Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45

Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser 145 150 155 160

Asp Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp 165 170 175

Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly 180 185 190

Ala Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys 195 200 205

Thr Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr 210 215 220

Glu lie His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys 225 230 235 240

Leu Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser 245 250 255

Glu Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser 260 265 270

Arg Cys Leu Glu Leu Gin Cys Gin Pro 275 280 (2)序列編號NO: 580資料： (i)序列特性： (A)長度：286胺基酸 O:\92\92747.DOC -329- 200413407 hIL-3受體促效劑pMONl 3416編碼序列，且該4254驗基對之載體片段係在於0 · 8 %之TAE凝膠上分離，並以溴化乙鍵染色後，使用Geneclean (BiolOl，Vista，CA)分離。使用部分之稼接反應物轉形大腸桿菌菌株DH5 α細胞（Life Technologies，Gaithersburg，MD)。於含有胺芊青黴素之培養平板上篩選轉形株菌。分離質體DNA，並進行定序，以確認正確之插入。所得之質體稱為pMON31108。

以pMON31108轉形大腸桿菌菌株JM101，以進行蛋白質表現，並自包含體内分離蛋白。質體PMON31108含有（序列編號NO: 13)之DNA序列，其編碼下列胺基酸序列：

Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val Ser lie Leu Met:

Asp Arg Asn Leu Arg Leu Pro Asn Lau Glu Ser Phe Val Arg Ala

Val Lys Aan Leu Glu Asn Ala Ser Gly 工le Glu Ala I丄e Leu Airg

Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg

His Pro lie lie Tie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu G丄n Ala Gin Glu Gin

Gin Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Asn Cys

Ser lie Met lie Asp Glu lie He His His Leu Lys Arg Pro Pro

Ala Pro Leu Tyr Val Clu Gly Gly Gly Gly Ser Pro Gly Glu Pro

Ser Gly Pro lie Ser Thr lie Asn Pro Ser Pro Pro Ser Lyss Glu

Ser His Lys Ser Pro Asn Met Ala Thr Gin Gly Ala Met Pro Ala

Phe Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala

Ser His Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg

His Leu Ala Gin Pro Ser G丄y Gly Ser Gly Gly Ser Gin Ser Phe

Leu Leu Ly3 Sex' Leu Glu Gin Val Arg Lys lie Gin Gly Asp Gly

Ala Ala Leu Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His

Pro Glu Glu Le^u Val Leu Leu Gly His Ser Leu Gly lie Pro Trp

Ala Pro lieu Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly

Cys Leu Ser Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu

Leu Gin Ala Leu Glu Gly lie Ser Pro Glu Leu Gly Pro Thr Leu

Asp Thr Leu Gin Leu Asp Val Ala Asp Phe Ala Thr Thr lie Trp

Gin Gin Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gin Pro {SEQ ： NO :496) (序列編號NO: 496) 實例80 O:\92\92747.DOC 330 - 200413407 pMON31109之建構使用述於「材料及方法」乙節中之方法III創造 pM〇N31109中之新N-端/C-端基因。使用引子組70 start (序列編號NO: 358)及69 rev (序列編號NO: 359)，自中間質體 Syntan3創造並擴增全長之新N-端/C-端hIL_3受體促效劑 pMON13416基因。以限制核酸内切酶Ncol及SnaBI切割處理含有新基因之所得片段。於1%之TAE凝膠上分離經切割之DNA，以溴化乙鍵染色，並使用Geneclean (Bio 1 01，Vista，CA)分離。使用 T4 DNA聚合酶（Boehringer Mannheim，Indianapolis，IN) ，使純化之經切割DNA片段稼接進入表現載體pMONl 3 189 中。該pMON13189 DNA已先經Ncol及SnaBI切割，以除去 hIL-3受體促效劑pMON13416編碼序列，且該4254鹼基對之載體片段係在於0.8%之TAE凝膠上分離，並以溴化乙錠染色後，使用Geneclean (BiolOl，Vista，CA)分離。使用部分之稼接反應物轉形大腸桿菌菌株DH5 α細胞（Life Technologies，Gaithersburg，MD)。於含有胺爷青黴素之培養平板上蒒選轉形株菌。分離質體DNA，並進行定序，以確認正確之插入。所得之質體稱為pMON31109。以pMON31109轉形大腸桿菌菌株JM101，以進行蛋白質表現，並自包含體内分離蛋白。質體pMON31109含有（序列編號NO: 14)之DNA序列，其編碼下列胺基酸序列： O:\92\92747.DOC -331 - 200413407

Asn Ala Ser Gly lie Glu Ala lie Leu Arg Asn Leu Gin Pro Cys

Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg Hi.s Pro lie lie lie

Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu Lys Leu Thr Phe Tyr

Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin Gly Gly Gly Ser

Gly Gly Gly Ser Gly Gly Gly Ser Asn Cys S^r 11^ Met lie Asp

Glu lie 工le His His Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp

Pro Asn Asn Leu Asn Asp Glu Asp Val Ser lie Leu MeC Asp Arg

Asn Leu Arg Leu Pro Asn Leu G1u Ser Phe Val Arg Ala Val Lys

Asn Leu Glu Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro

Ser Gly Pro lie Ser Thr 工le Asn Pro Ser Pro Pro Ser Lys Glu

Ser His Lys Ser Pro Asn Met Ala Thr Gin Gly Ala Met: Pro Ala

Phe Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala

Ser His Leu Gin. Ser Phe Leu Glu Val Ser Tyr Axg Val Leu Arg

His L·各a Ala Gin Pro Ser Gly Giy Ser Gly Gly Ser Gin Ser Phe

Leu Leu Lys Ser Lou Glu Gin Val Arg Lys lie Gin Gly Asp Gly

Ala Ala Leu Gin Glu Lys beu Cys Ala Thr Tyx Lys Leu Cys His

Pro Gl'.i Glu Leu Val Leu Leu Gly His Ser Leu Gly lie Pro Trp

Ala Pro Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly

Cys Leu Ser Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu

Leu Gin Ala Leu Glu Gly He Ser Pro Glu Leu Gly Pro Thr Leu A&p Thr Leu Gin hen Asp Val Ala Asp Phe Ala Thr Thr lie Trp

Gin Gin Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gin Pro (SEQ ID NO:497) (序列編號NO: 497) 實例81 pMON31110之建構使用述於「材料及方法」乙節中之方法III創造 pMON3 1110中之新N-端/C-端基因。使用引子組91 start (序列編號NO: 360)及90 rev (序列編號NO: 361)，自中間質體 Syntan3創造並擴增全長之新N-端/C-端hIL-3受體促效劑 pMON13416基因。以限制核酸内切酶Ncol及SnaBI切割處理含有新基因之所得片段。於1%之TAE凝膠上分離經切割之DNA ’以溴化乙鉸染色，並使用Gene clean (BiolOl，Vista，CA)分離。使用 T4 DNA聚合酶（Boehringer Mannheim，Indianapolis，IN) ，使純化之經切割DNA片段稼接進入表現載體pMON13189 中。該pM〇N13189 DNA已先經Ncol及SnaBI切割，以除去

O:\92\92747.DOC - 332 - 200413407 hIL-3受體促效劑pMON13416編碼序列，且該4254鹼基對之載體片段係在於0.8%之TAE凝膠上分離，並以溴化乙錠染色後，使用Geneclean (BiolOl，Vista，CA)分離。使用部分之稼接反應物轉形大腸桿菌菌株DH5 α細胞（Life Technologies，Gaithersburg，MD)。於含有胺爷青徽素之培養平板上篩選轉形株菌。分離質體DNA，並進行定序，以確認正確之插入。所得之質體稱為pMON3 1110。以PMON31110轉形大腸桿菌菌株JM101，以進行蛋白質表現，並自包含體内分離蛋白。質體PMON31110含有（序列編號NO: 15)之DNA序列，其編碼下列胺基酸序列：

Ala Pro Ser Arg His Pro lie lie lie Lys Ala Gly Asp Tip Gin

Gl*u Phe Arg Glu Lys Thr Phe Tyr Leu Val Thr Leu Giu Gin

Ala Cln Glu Gin Gin Gly Gly Gly Scr Gly Gly Gly Ser Gly Gly

Giy Ser Asn Cys Sez· lie MeL 工le Asp Glu lie lie Kis His Leu I«ys Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp

Glu Asp Val Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn

Leu Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser

Gly lie Glu Ala lie Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser

Ala Thr Ala Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro

Ser Gly Pro lie Ser Thr lie A3n Pro Ser Pro Pro Ser Lys Glu

Ser His Lys Ser Pro Asn Met Ala Thr Gin Gly Ala Met Pro Ala

Phe Ala Scr Ala Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala

Ser His Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg Arg

His L^u Ala Gin Pro Ser Gly Gly Ser Gly Gly Ser Gin Ser Phe

Leu Leu Lys Scr Leu Glu Gin Val Arg Lys lie Gin Gly Asp Gly

Ala Ala Leu Gin Glu Lys Leu Cys Ala Thr Tyr Lya Leu Cys Hia

Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly lie Pro Trp

Ala. Pro Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly

Cys Leu Ser Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu

Lgu Gin Ala Leu Glu Gly lie Ser Pro Glu Len Gly Pro Thr Leu

Asp Thr Leu Gin Leu Asp Val Ala Asp Phe Ala Thr Thr lie Trp

Gin Gin Met Glu Gin L«u Gly Met Ala Pro Ala Leu Gin Pro (SEQ ID NO :493) (序列編號NO: 498) 實例82 O:\92\92747.DOC - 333 - 200413407 pMON31111之建構使用述於「材料及方法」乙節中之方法III創造 pMON31 111中之新N-端/C-端基因。使用引子組1 0 1 start ( 序列編號NO: 362)及100 rev (序列編號NO: 363)，自中間質體Syntan3創造並擴增全長之新N-端/C-端hIL-3受體促效劑 pMON13416基因。以限制核酸内切酶Ncol及SnaBI切割處理含有新基因之所得片段。於1%之TAE凝膠上分離經切割之DNA，以溴化乙鍵染色，並使用Gene clean (BiolOl，Vista，CA)分離。使用 T4 DNA聚合酶（Boehringer Mannheim，Indianapolis，IN) ，使純化之經切割DNA片段稼接進入表現載體pMONl31 89 中。該pMON13189 DNA已先經Ncol及SnaBI切割，以除去 hIL-3受體促效劑pMONl 3416編碼序列，且該4254鹼基對之載體片段係在於0.8%之TAE凝膠上分離，並以溴化乙錠染色後，使用Geneclean (BiolOl，Vista，CA)分離。使用部分之稼接反應物轉形大腸桿菌菌株DH5 α細胞（Life Technologies，Gaithersburg，MD)。於含有胺爷青黴素之培養平板上篩選轉形株菌。分離質體DNA，並進行定序，以確認正確之插入。所得之質體稱為PMON31111。以ρΜΟΝ31111轉形大腸桿菌菌株JM101，以進行蛋白質表現，並自包含體内分離蛋白。質體PMON31111含有（序列編號NO: 16)之DNA序歹，其編碼下列胺基酸序列： O:\92\92747.DOC - 334 - 200413407

Ala Gly Asp Trp G.ln Glu Phe Atrg Glu Lys Lmi Thr TPhe Tyr Leu

Val Tlir Leu Glu Gin Ala Gin Glu Gin Gin Gly Gly Gly Ser Gly

Gly Gly Ser Gly Gly Gly Ser Asn Gys Ser 工le Met 工le Asp Glu lie lie His His Leu Lys Arg Pro Pro Ala Pro Leu L^u Asp Pro

Asn Asn Leu Asn Asp Glu Asp Val Ser lie Leu Met Asp Arg Asn

Leu Arg Leu Pro Asn Leu Glu Ser Ph.e Val Arg Ala Val Lys Asn

Leu Glu Asn Ala Ser Gly lie Glu Ala He L^u Arg Asn Leu Gin

Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro lie 工le lie Lys Tyr Val Glu Gly* Gly Gly Gly Ser Pro Gly Glu i)ro

Ser Gly Pro Tie Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu

Ser His Lys Ser Pro Asn Met Ala Thr Gin Gly Ala Met Pro Ala

Phe Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala

Ser His Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg

His Leu Ala Gin Pro Sor Gly Gly Ser Gly Gly Ser Gin Ser Phe

Leu Leu Lys Ser Leu Glu Gin Val Arg Lys lie Gin Gly Asp Gly

Al.a Ala Leu Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His

Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly lie Pro Trp

Ala Pro Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly

Cys Leu Ser Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu

Leu Gin Ala Leu Glu Gly Tie Ser Pro G\n Leu Gly Pro Thr Leu

Asp Thr Leu Gin Leu Asp Val Ala Asp Phe Ala Thr Thr 工le Trp

Gin Gin Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gin Pro (SEQ ID NO:499) (序列編號NO·· 499) 實例83 pMON31112之建構建構pMON31112，其係含有編碼可活化hIL-3受體及 G-CSF受體之多功能造血素受體促效劑之DNA序列之質體。以限制酶Ncol及Xmal切割處理質體pMON13189，產生鲁 Ncol、Xmal載體片段，並將其自〇·8%瓊脂凝膠中分離並純化。以Ncol及EcoRI，對取自第二質體pMON13222 (WO 94/12639 ，US系列編號#08/411，796)之DNA進行切割處理，產生281鹼基對之Ncol、EcoRI片段。自1.0%瓊脂凝膠中分離並純化此片段。黏連兩寡核苷酸SYNNOXA1.REQ (序列編號NO: 350)及 SYNNOXA2.REQ (序列編號NO: 351)，並使其與取自pMON 13 222之281鹼基對DNA片段一同稼接進 O:\92\92747.DOC - 335 - 200413407 入取自pMON13189之DNA載體片段中。再將部分之稼接反應混合物轉形大腸桿菌K-12菌株JM101。於含有胺苄青黴素之培養平板上篩選轉形株菌。分離質體DNA，以限制分析進行分析，顯示一EcoRV片段之存在，並進行定序，以確認正確之插入子。質體pMON31112含有（序列編號NO: 37)之DNA序列，其編碼下列胺基酸序列：

MetAlaAsnCysSerAsnMetlleAspGluJleTleThrHisLeiiLysGlnPfoProLeuProLeu

LeuAspPheAsnAsnLeuAsnGlyGluAspGlnAspIleLeuMetAspAsnAsnLeuArgArgPro

AsnLeuGluAlaPheAsnArgAlaValLysSerLeuGlnAsnAlciSerAlalleGluSerlleLeu

LiysAsriLeuLeuProCysLeuProLeuAlaThrAlaAlaProThrArgHisProIleHisIleLys

AspGlyAspTrpAsnGluPheArgArgLysLeuThrPheTyrLeuLysThrLeuGluAsnAlaGln

AlaGlnGlnTyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrlle

AsnProSerProProSerLysGluSerHisLysSerProAsnMetAlaThrGlnGlyAlaMetPro

AlaPheAlaSerAlaPheGlnArgArgAlaGlyGlyValLeuValAlaSerHisLeuGlnSerPhe

LeuGluValSerTyrArgValLeuArgHisLeuAlaGlnProSerGlyGlySerGlyGlySerGln

SeΓPheL·euJL·euL·ysSerLeuGluGlnValArgIιys工leGlΓlGlyAspGlyAleιAlέiIJeuGlLlGlu

LysLeuCysAlaThrTy^LysLeTjCysHisProGluGluLeuValLeuLeuGlyHisSerlieuGly

IleProTrpAlaProLeuSerSerCysProSerGlnAlaLeuGlnLeuAlaGlyCysLeuSerGln

LeuHisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAlciLeuGluGlylleSerProGluLeu

GlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAlaThrThrlleTrpGlriGlnMat

GluGluLeuGlyMetAlaProAlaLeuGlnPro (SEQ ID NO:505) (序列編號NO: 505) 實例84 pMON31113之建構建構pMON3 1113，其係含有編碼可活化hIL-3受體及 G-CSF受體之多功能造血素受體促效劑之DNA序列之質體。以限制酶Ncol及Xmal切割處理質體PMON13197，產生 Ncol、Xmal載體片段，並將其自0.8%瓊脂凝膠中分離並純

化。以Ncol及EcoRI，對取自第二質體PMON13239 (WO 94/12639 ，US系列編號#08/411，796)之DNA進行切割處理，產生281鹼基對之Ncol、EcoRI片段。自1·〇%瓊脂凝膠中 O:\92\92747.DOC -336 - 200413407 分離並純化此片段。黏連兩寡核嘗酸SYNNOXA1.REQ (序列編號NO·· 350)及 SYNNOXA2.REQ (序列編號no: 351)，並使其與取自pMON 13 23 9之281鹼基對DNA片段一同稼接進入取自pMON13197之DNA載體片段中。再將部分之稼接反應混合物轉形大腸桿菌K-12菌株JM101。於含有胺苄青黴素之培養平板上篩選轉形株菌。分離質體DNA，以限制分析進行分析，顯示一EcoRV片段之存在，並進行定序，以確認正確之插入子。質體PMON31113含有（序列編號NO: 38)之DNA序列，其編碼下列胺基酸序列：

Met-AlaAsnCysSerAsnMet 工 1βΑ3ρ01ιιΙ1θΙ1βΤ1ΐΓΗΐ3ΐιβυΧιγ36ΐηΡι:οΡι：ϋΙιβυΙ)Γ〇ΐ4€ΐι LeuAspPheAsnAsnLeuAsnGlyGluAspGlnAspIleLeuMetGluAsnAsnLeuArgArgPro AsriLeuGluAlaPheAsnArgAlaValLysSerLeuGlnAsnAlaSerAlalleGluSerlleLeu Ι^ΑδϋΙ^ιιΙ^ιιΡΓοΟγΞΐιβιιΡΓοΙιβιιΑίαΤίιι-ΑΐέΐΑΐάΡίΓοΤϊίΓΑΜίϋβΡΓΟΙΙβΙΙβΙΙοΑΝ AspGlyAspTrpAsnGluPheArgArgLysLeuThrPheTyrLeuLysTbrLeuGluAsnAlaGln AlaGlnGlnTyrValGluGlyGlyClyGlyS^xProGlyGluProSerGlyProIleSerThrlle AsnProSerProProSerLysGluSerHi3LysSerProAsnMetAla.ThrGlnGlyAldMetPro AlaPheAlaSerAlaPheGlnArgArgAlaGlyGlyValLeuValAlaSerHisLeuGlnSerPhe LeuGluValSerTyrArgValLeuArgHisLeuAlaGlnProThrProLeuGlyProAlaSerSGr

LeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHisProGluGluLeuValLeuLeuGlyHis SerLeuGlyllcProTrpAlaProIieuSerSerCysPiroSerGlnAlaLeuGlnLeuAlaGlyCYs LeuSerGlnLeuRisSerGlyLeuPheLeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlylleSer ΡΊ：ο01·αΙ^θΐι01γΡΓ〇ΤΒΓΐ^υΛ5ρΤ1ΐΓΐΙβιιβ1ηΙ^ϋΑ3；ρν3·ΐΑΐϋΑίφΡϊΐθΑΐ2Τ1ιι'Ί1ι;ι:工 leTrp GlnGlnMotGluGluLeuGlyMetAlaProAlaLeuGlnPro (SEQ ID NO：506) (序列編號NO: 506) 實例85 pMON31114之建構建構ρΜΟΝ31114，其係含有編碼可活化hIL-3受體及 G-CSF受體之多功能造血素受體促效劑之DNA序列之質體。以限制酶Ncol及Xmal切割處理質體pMON13189，產生 Ncol、Xmal載體片段，並將其自0.8%瓊脂凝膠中分離並純 O:\92\92747.DOC - 337 - 200413407 化。以Ncol及EcoRI，對取自第二質體pMON13239 (WO 94/12639 ，US系列編號#08/411，796)之DNA進行切割處理，產生281驗基對之Ncol、EcoRI片段。自1 ·〇%瓊脂凝膠中分離並純化此片段。黏連兩寡核苷酸SYNNOXA1.REQ (序列編號NO: 350)及 SYNNOXA2.REQ (序列編號NO: 351)，並使其與取自PMON13239之281鹼基對DNA片段一同稼接進入取自PMON13189之DNA載體片段中。再將部分之稼接反應混合物轉形大腸桿菌K-12菌株JM101。於含有胺芊青黴素之培養平板上篩選轉形株菌。分離質體DNA，以限制分析進行分析，顯示一EcoRV片段之存在，並進行定序，以確認正確之插入子。質體pMON31114含有（序列編號NO: 39)之DNA序列，其編碼下列胺基酸序列：

MetAlaAsnCysSerAsnMet 工 1θΑ3ρΟ1ιιΙΐ0ΐΐ€Τΐι:ι:Η:ί3ΐί〇ιιΙι]/3〇1ηΡ2：οΡι:οΙ^0ΐιΡΓ〇Ι»βιι Le\iAspPheAsnAsnLe,aAsnGlyGluAspGlnAspIleLeuMetGluAsnA3nI.euArgArgPro

LysAsnLeuLeuProCysLcuProLeuAlaThrAlaAlaProThrArgHisProIleTlelleArg AspGlyAspTrpAsnGluPheArgArgLysLeuThrPheTyxLeuLysThrLeuGluAsnAlaGln Α1β0ίΐΓ^1ηΤγ2：ν3ΐβ1ι^1γΟ1γΟ1γ^γ·36ΓΡΓ〇(^1γΟΐΛΐΡΓ〇3β；Γαΐ;γ：ΡΓ〇Ι1θ3〇ΓΤΐΐτΙ1β AsnProSerProProSerLysGluSerHisLysSerProAsnMetAlaThrGlnGlyAlaMetPro AlaFheAlaSerAlaPheGlnArgArgAlaGlyGlyValLeuValAlaSerHiaLGuGlnSerPhe LeuGluVaISerTyrArgValLeuArgHisLeuAlaGinProSerGlyGlySerGiyGlySerGla 3θ：Σ：ΡΐΐθΙ^θυΙ^θ\ιΙϋ}/3：2ζ：ι:Ι^β\ι01ια01πν5ΐ1Α：Γ9ΐιγ3ΐ1β01η01γΑ3ρ01γΑΐ5Α1δΙιβ\:01ηα·να LysLeuCysAlaThrTyrLysLeuCysHisProGluGluLeuValLeuLeuGlyHisSerLeuGly IleProTrpAIaProLeuSftrSerCysProSftrGlnAlaLeuGlnLeuAlaGlyCysLeuSerGln LeuHisSerClyLeuPhGLeuTyrGlnGlyLeuLeuGlnAlaLeuGluGlylleSerProGluLeu GlYProThrLeuAspThrLeuGlnLeuAspValAlaAapPheAlaThrThrlleTrpGlnGlilMet GluGluLeuGlyMefcAlaProAlaT.euGlnPro (SEQ ID NO:507) (序列編號NO: 507) 實例86 pMON31115之建構建構pMON31115，其係含有編碼可活化hIL-3受體及 O:\92\92747.DOC - 338 - 200413407 G-CSF受體之多功能造血素受體促效劑之DNA序列之質體。以限制酶Ncol及Xmal切割處理質體pMON13 197，產生 Ncol、Xmal載體片段，並將其自0.8%瓊脂凝膠中分離並純化。以Ncol及EcoRI，對取自第二質體pMON13222 (WO 94/12639 ，US系列編號#08/411，796)之DNA進行切割處理，產生28 1驗基對之Ncol、EcoRI片段。自1 .〇%瓊脂凝膠中分離並純化此片段。黏連兩寡核苷酸SYNNOXA1.REQ (序列編號NO: 350)及 SYNNOXA2.REQ (序列編號NO: 351)，並使其與取自pMON 1323 9之281鹼基對DNA片段一同稼接進入取自pMON13197之DNA載體片段中。再將部分之稼接反應混合物轉形大腸桿菌K-12菌株JM101。於含有胺苄青黴素之培養平板上篩選轉形株菌。分離質體DNA，以限制分析進行分析，顯示一EcoRV片段之存在，並進行定序，以確認正確之插入子。質體PMON31115含有（序列編號NO: 40)之DNA序列，其編碼下列胺基酸序列： rjeuAspPheAsnAsnLeuAsnGlyGluAspGlnAspIleLeuMetAspAsnAsnLeuArgArgPro

AsiiLeaGluAlaPheAsnArgAlaValLysSerLeuGlnAsnAlaSerAlalleGluSerlleLGu 11ιγ5Α5ΠΙιθΐιΙϋθ\ιΡϊ*ο(ϋγ3ΐι€\ιΡι:οΙιβ\}Α1ειΤ]ηΓΑ1οΑ1ειΡΓΌΤΐΊ：ΓΑΓ9ΐϋ5ΡΓ〇Ι1βΙ1:ΐ5ΐΐ8ΐι：/3

AspGlyAspTrpAsnGluPheArgArgLysLeuThrPheTyrLeuLysThrLeuGluAsnAlaGln

AlaGlnGlnTyrValGluGlyGlyGlyGlySerProGlyGluProSerGlyProIleSerThrlle

AsnProSerProProSerLysGluSerHisLysSerProAsnMetAlaThrGlnGlyAlaMetPro

AlaPheAlaSerAlaPheGln/\rgArgAlaGlyGlyValLeuValAlaSerHisLeuGlnSerPhe

LeuGluValSerTyrArgValLeuAxgHisLeuAlaGlnProThrProLeuGlyProAlaSerSer

TjeuProGlnSerPheTjeuT.euTyR^rLmiGluQlnValArgLysIleGlnGlyAspGlyAlaAla

LeuGlnGluLysLeuCysAlaThrTyrLysLeuCysHisProGlTjLGluLeuValLeuLeuGlyHis

SerLeuGlylleProTrpAlaProLeuSerSerCysProSerGlnAlaLeuGlnLeuAlaGlyCya Ι^ιι3€〇^1ηΙ^υΗ:Ιδ3β:τ61γ1>·υΡ1^ΐ.€^Τγπ·；1τ^1γΤΛβυΙ^Λΐ(；：ΙηΑΐΗΐ^ι〇1\ι(ηγΙ：1^ΜΓ ProGluLeuGlyProThrLeuAspThrLeuGlnLeuAspValAlaAspPheAlaThrThrlleTrp GlnGlnMetGluGluLeuGlyMetAlaProAlaLeuGlnPro (SEQ ID N0:508) O:\92\92747.DOC - 339 - 200413407 (序列編號Ν〇·. 508) 實例87 多功能造血素受體促效蛋白之活體外活性測定多功能造血素受體促效蛋白之濃度可使用根據親和純化之多株抗體之夾曾ELIS Α分析進行測定。或者，蛋白濃度亦可藉由胺基酸組成分析而測定。多功能造血素受體促效劑之生物活性可使用許多活體外分析測定。舉例而言，可結合hIL-3受體及G-CSF受體之多功能造血素受體促效劑可 0 在細胞增殖分析中，使用表現hIL-3及/或G-CSF受體之細胞系進行分析。此種分析之一為AML-193細胞增殖分析。 AML-193細胞可對hIL_3及G-CSF產生反應，因而可允許 hIL-3/G-CSF多功能造血素受體促效劑結合生物活性之測定。另一此種分析係TF1細胞增殖分析。此外，亦可使用其他因子依賴性之細胞系，諸如， M-NFS_60(ATCC.CRL 1 83 8)或3 2D，其為鼠類IL-3依賴性細胞。IL-3之活性係具有種類專一性者，而G-CSF之活性係 φ 不具種類專一性。因此，可獨立測定hIL-3/G-CSF多功能造血素受體促效劑中G-CSF組成份之生物活性。可以含有編碼目標受體之基因之質體，轉染不表現特定配位體之受體之細胞系，諸如，BHK或鼠類Baf/3。此等細胞系之實例之一為經hG-CSF受體轉染之BaF3 (BaF3/hG-CSF)。多功能造血素受體促效劑在此等細胞系中之活性可與hIL-3或 G-CSF之單一活性或兩者進行比較。於BaF3/hG-CSF細胞增殖分析及TF 1細胞增殖分析中進行分析之本發明例示性多 O:\92\92747.DOC -340 - 200413407 功能造血素受體促效劑之生物活性示於表5及表6。多功能造血素受體促效劑之生物活性係以相較於具有hIL-3及 G-CSF受體結合活性之標準蛋白pMON 13056 (WO 95/21254) 之相對活性表示。於BaF3/c-mpl細胞增殖分析及TF 1細胞增殖分析中進行分析之本發明例示性多功能造血素受體促效劑之生物活性示於表7及表8。

O:\92\92747.DOC -341 - 200413407 表5 雙重IL-3/G-CSF受體促效劑之細胞增殖活性

BaF3/hG-CSF 受體 TF1 ρΜΟΝ 細胞增殖分析細胞增殖分析相對活性* 相對活性* 13182 0.015 1.1 13183 0.02 nd 13184 0.01 0.3 13185 0.023 0.36 13186 0.36 0.45 13187 0.07 0.26 13188 0.64 1.3 13189 0.58 1.37 13190 0.045 1.2 13191 0.14 2.7 13192 0.09 2.2 13193 0.06 3.0 25190 nd nd 25191 0.43 1.2 13194 nd nd 13195 1.3 4.3 13196 0.66 0.5 13197 0.6 0.77 13198 0.6 0.5 13199 nd nd 15982 0.7 1.9 15981 0.068 1.2 15965 0.7 0.82 15966 0.36 1.48 15967 0.62 1.37

nd二未測定 *多功能造血素受體促效劑之生物活性係以相較於標準蛋白 PMON13056之相對活性表示，η係3或以上。 O:\92\92747.DOC -342 - 200413407 表6 雙重IL-3/G-CSF受體促效劑之細胞增殖活性 ρΜΟΝ BaF3/hG-CSF 受體 TF1 細胞增殖分析細胞增殖分析相對活性相對活性 31104 + + 31105 + + 31106 + + 31107 nd nd 31108 + + 31109 + + 31110 nd nd 31111 nd nd 31112 + + 31113 + + 31114 + + 31115 + + 31116 nd nd 31117 nd nd nd=未測定十多功能造血素受體促效劑之生物活性係以相較於標準蛋白pMON13 05 6之相對活性表示（n = 1或2)。 π + π表示該分子係與ΡΜΟΝ13056相當。 O:\92\92747.DOC -343 - 200413407 表7 細胞增殖活性 ρΜΟΝ BaG/c-mpl 受體細胞增殖分析相對活性* TF1 細胞增殖分析相對活性 28505 - + 28506 - + 28507 - + 28508 - + 28509 + 28510 - + 28511 + + 28512 + + 28513 + + 28514 + + 28519 - + 28520 - + 28521 - + 28522 - + 28523 - + 28524 - + 28525 + + 28526 + + 28533 - + 28534 - + 28535 - + 28536 - + 28537 爾 + 28538 - + 28539 + + 28540 + + 28541 + + 28542 + + 28543 + + 28544 + + 28545 + + *活性係在經c-mpl受體轉染之Baf3細胞系中，相對於c_ 配位體（1-153)測定。 =活性係相對於ρΜΟΝ 1 3 05 6測定。 O:\92\92747.DOC -344 - 200413407 使用類似之方式，亦可使用其他熟習此項技術者所知之因子依賴性細胞系測量目標多功能造血素受體促效劑之生物活性。可使用甲基纖維素分析測定多功能造血素受體促效劑對於活體外之造血組細胞之擴展及不同類型造血集落 <模式之效應。甲基纖維素分析可提供前體細胞頻率之估口十值’因其係測量每10 0，0 0 0輸入細胞之組細胞頻率。長期之基質依賴性培養物已被用於探究原始造血組細胞及幹細胞。可使用此一分析測定多功能造血素受體促效劑是否可刺激非常原始之造血組細胞及/或幹細胞之擴展。此外，可進行限制性稀釋培養，以指出為多功能造血素受體促效劑刺激之原始祖細胞頻率。 O:\92\92747.DOC 345 - 200413407 表8 pMON# IL-3促效劑活性 (AML細胞增殖分析） c-mpl受體促效劑活性 (Baf/3-c-mpl 細胞增殖分析） 28505 + - 28506 + - 28507 + - 28508 + 睡 28509 + - 28510 + - 28511 + + 28512 + + 28513 + + 28514 + + 28515 + + 28519 + 28520 + - 28521 + - 28522 + - 28523 + 28524 + - 28525 + + 28526 + + 28527 + + 28528 + + 28529 + + 28535 + - 28539 + + 28540 + + 28541 + + 28542 + + 28545 + + 28551 + + 28571 + +

O:\92\92747.DOC - 346 - 200413407 實例88 使用述於WO 94/1263 9及WO 94/12638中之PCR謗變技術，製備含有單一或多重胺基酸取代之G-CSF變體。熟習此項技術者亦可使用許多其他方法製備此等變體及其他變體 (亦即，胺基酸取代、插入或缺失，及N-端或C-端延伸），該等方法包括合成基因組裝或定位謗變（參見，Taylor et al.， Nucl. Acids Res·，13:7864-8785 [1985]; Kunkel ete al.? Proc. Natl. Acad. Sci. USA, 82:488-492 [1985]; Sambrook et al·，Molecular Cloning: A Laboratory Manua;，2nd ed·， Cold Spring Harbor Laboratory Press，Cold Spring Harbor， NY，[1989]; WO 94/12639 及 WO 94/12638)。此等取代可分別製備，亦可結合其他胺基酸取代，及/或缺失，及/或插入，及/或延伸一同製備。在對變化處進行序列辨識之後，可將質體DNA轉染進入適當之哺乳動物細胞、昆蟲細胞、或細菌株（如，大腸桿菌）進行製備。已知具有活性之G-CSG 變體包括第1位（Thr至Ser、Arg或Gly)、第2位（Pro至Leu)、第3位（Leu至Arg或Ser)、及第17位（Cys至Ser)之取代，以及胺基酸 1-11之缺失（Kuga et al· Biochemical and Biophysical Research Comm. 159:103-1 1 1 (1989))。此等 G-CSF胺基酸取代變體可作為樣板，以創造具有新N-端及新C-端之G-CSG 受體促效劑。G-CSF胺基酸取代變體之實例如表9所示。實例89 G-CSF胺基酸取代變體之生物活性測定可使用經人類G-CSF轉染之Baf/3細胞系分析G-CSF胺基 O:\92\92747.DOC - 347 - 200413407 酸取代變體之細胞增殖活性。G-CSF胺基酸取代變體之實例之生物活性如表9所示。係表示與天然蛋白相當之活性，而係表示顯著較低或無可測得之活性。表9 胺基酸位置天然胺基酸突變胺基酸活性* 13 Phe Ser + 13 Phe His + 13 Phe Thr + 13 Phe Pro + 16 Lys Pro + 16 Lys Ser + 16 Lys Thr + 16 Lys His + 18 Leu Pro + 18 Leu Thr + 18 Leu His + 18 Leu Cys + 18 Leu Ilee + 19 Glu Ala - 19 Glu Thr 19 Glu Arg - 19 Glu Pro - 19 Glu Leu - 19 Glu Ser - 22 Arg Tyr + 22 Arg Ser + 22 Arg Ala + 22 Arg Thr + + 24 lie Pro + 24 lie Leu + 24 lie Tyr +

O:\92\92747.DOC -348 - 200413407 表9續胺基酸位置天然胺基酸突變胺基酸活性* 27 Asp Gly + 30 Ala lie + 30 Ala Leu + 34 Lys Ser + 43 His Gly + 43 His Thr + 43 His Val + 43 His Lys + 43 His Trp + 43 His Ala + 43 His Arg + 43 His Cys + 43 His Leu + 44 Pro Arg + 44 Pro Asp + 44 Pro Val + 44 Pro Ala + 44 Pro His + 44 Pro Gin + 44 Pro Trp + 44 Pro Gly + 44 Pro Thr + 46 Glu Ala + 46 Glu Arg + 47 Leu Thr + 49 Leu Phe + 49 Leu Arg + 49 Leu Ser + 50 Leu His + 54 Leu His +

O:\92\92747.DOC - 349 - 200413407 表9續胺基酸位置天然胺基酸突變胺基酸活性* 67 Gin Lys + 67 Gin Leu + 67 Gin Cys + 70 Gin Pro + 70 Gin Leu + 70 Gin Arg + 70 Gin Ser + 104 Asp Gly + 104 Asp Val + 108 Leu Ala + 108 Leu Val + 108 Leu Arg + 108 Leu Gly + 108 Leu Trp + 108 Leu Gin + 115 Thr His + 115 Thr Leu + 115 Thr Ala + 144 Phe His + 144 Phe Arg + 144 Phe Pro + 144 Phe Leu + 144 Phe Glu + 146 Arg Gin + 147 Arg Gin + 156 His Asp 麵 156 His Ser + 156 His Gly +

O:\92\92747.DOC - 350 - 200413407 表9續胺基酸位置天然胺基酸突1 1胺基酸活性* 159 Ser + 159 Ser + 159 Ser + 159 Ser + 159 Ser + 162 Glu - 162 Glu + 162 Glu + 163 Val + 163 Val + 163 Val + 165 Tyr nd 169 Ser + 169 Ser + 169 Ser + 170 His + 170 His + *相對於天然hG-CSF之活性 nd = 未測定 O:\92\92747.DOC -351 - 200413407 實例90 使用NCOFLT、HIND160及HIND165 PCR引子，自人類骨髓聚A+ RNA (Clontech)，擴增三株flt3配位體純系（根據製造商之建議條件）。對此等經擴增PCR產物進行凝膠純化，並將其選殖進入BHK表現載體pMON5723中，產生 pMON30237 (NCOFLLT + HIND160) 、 pMON30238 (NCOFLT + HIND165)、以及缺失純系 pMON30239 (NCOFLT + HIND 165)。pMON30239中之缺失係胺基酸殘基 89至 106。實例91 使用數種方法及連接子類型，建構序列重排之flt3受體促效劑。第一組之建構，其含有連接肽（SerGlyGlyAsnGly)X (其中 X=l、2或3)，且具有斷裂點39/40、65/66、及89/90，係使用述於Mullins et al.之兩階段PCR法製備，其中係在第一 PCR步騾中，分別製備各終序列重排分子之前半部及後半部，再於第二PCR步驟中，結合第一反應步驟之產物對，並於無外加引子之情形下進行延伸。舉例而言，為使用 SerGlyGlyAsnGly 序歹丨J 編號 NO: 786、SerGlyGlyAsnGlySerGlyGly AsnGly序列編號NO: 787、及 SerGlyGlyAsnGlySerGlyGlyAsnGlySer GlyGlyAsnGly序列編號NO: 788胺基酸連接子製備三種89/90 斷裂點前體分子，其先產生六種PCR產物。於第一步驟PCR 反應中使用下列引子對：a) 89For/L5B ; b) 89For/L10B ; c) 89For/L15B ； d) 89Rev/L5A ； e) 89Rev/L10A ;及 f) 891^¥/1^15八。使用同樣之方法製備卩：^€^3 23 21 (3 9/40斷裂 0\92\92747.DOC - 352 - 200413407 點，引子對 39For/L10B 及 39Rev/L10A)及 pMON32325 (65/66 斷裂點，引子對65For/L5B及65Rev/L5A)前體。除非於下另外記載者’所有下述之PCR反應皆使用PCR Optimizer Kit (Invitrogen)之組成份，以及根據製造商建議流程之條件。反應如下設置：結合各50皮莫耳之引子，1〇微升之5X緩衝

溶液B [300 mM Tris-HCl (pH 8.5)，10 mM MgCl2，75 mM (NH4)2S04]，5 U Taq聚合酶，以及100納克（ng)之熱變性 DNA(在此實例中為pMON30238)樣板，並以dH20加至45微升之終體積。先將反應物預置於80°C 1-5分鐘，再將5微升之 lOmMdNTP 加入各反應，並在於 perkinElmermodel480 DNA熱循環儀中進行擴增之前，先於94。(：進行熱變性2分鐘。在下列條件下完成7循環之DNA擴增：94°C之熱變性1分鐘’ 65°C之黏連2分鐘，接續72°C之延伸3分鐘。再進行23 循環之94°C熱變性1分鐘，接續72°C黏連/延伸4分鐘，最後進行72°C之延伸7分鐘。除pMON32328外，使PCR擴增產物於1.2% TAE瓊脂凝膠上分離，切除具有適當大小之條帶（主擴增產物），並使用Geneclean II (Bio 101)純化。將樣本重新懸浮於10彳政升之dH2〇中。pMON3 23 28之擴增產物係使用职2&“？0&(^3111；?套組听〇111啡）直接純化，並溶析於5〇微升之dH20中。用於建構pMON32322前體分子（39/40斷裂點，引子對 39For/L5B及39Rev/L5A)之方法係經修飾：樣板之量增加至】微克，PCR擴增之條件變更如下：6循環之94°C 1分鐘，65°C 2 分鐘，及72°〇2 1/2分鐘，再接續15循環之94。(：：1分鐘，7〇。(：2 O:\92\92747.DOC - 353 - 200413407 分鐘，及72°C 2分鐘，最後進行一次72°C之延伸7分鐘。第二PCR步驟使用取自第一PCR步驟之凝膠純化前體分子，如下作為引子/樣板之組合··各5微升之前體分子（例如，為製備 pMON32328，使用取自引子對 89For/L5B 及 89Rev/L5A 之 PCR 產物），10微升之5X緩衝溶液B，5 U Taq聚合酶，以及24微升之dH20。於80°C加熱反應物5分鐘，加入5微升之10 mM dNTP ，並於94°C進行熱變性2分鐘。DNA擴增反應之條件如下：15 循環之94°C 1分鐘，69°C 2分鐘，接續72°C 3分鐘。為進行完籲整之延伸，於最後一循環後，再接續72°C 7分鐘之單一延伸步驟。在pMON32325 (65For/L5B及65Rev/L5A之產物）之製備中，將80°C之加熱時間減至2分鐘，並將循環數減至1〇循環。於 1 ·2% TAE瓊脂凝膠上，使用Geneclean II，對具有適當大小之 PCR反應產物進行純化。在pm〇N32322 (39For/L5B及 39Rev/L5A)之製備中，將黏連溫度減至68°C，且將延伸時間減至2分鐘。此外，PCR產物係使用Wizard PCR Clean UP套組 (Promega)，根據供應商建議之流程進行純化。如下修飾 _ pMON32326 (89F〇r/L15B 及 89Rev/L15A 之 PCR產物）之第二 PCR步騾。如上建立三組PCR反應，惟使用不同類型之緩衝溶液（使用5X緩衝溶液B、D、或J - PCR Optimizer Kit)。緩衝溶液D及J與緩衝溶液B之差異僅在pH或[MgCl2]。緩衝溶液D之 [MgCl2]係3.5 mM，而緩衝溶液J之pH係9.5。如下修飾流程·· PCR循環之數目增為20，且在第10、15、及20循環結束之時分別抽取15微升之樣本。於1.2% TBE瓊脂凝膠上，以5微升之各時間點樣本’分析擴增產物之存在。集合剩餘之緩衝溶液B、 O:\92\92747.DOC -354 - 200413407 D、及J PCR反應混合物，並使用wizard PCr C1_ Up Kiut程，進行後續之純化。將DNA溶析於50微升之dH20中。以Ncol/Hindlll，使用兩種標準切割處理條件之一，對取自第二步騾PCR反應之經純化樣本進行切割處理。就以Genedean II純化之樣本而言，將10微升之DNA，在20微升之反應物中，以各7.5 U之Ncol/Hindlll，在37°C下進行2小時之切割處理，並於1.1% TAE瓊脂凝膠上，以Geneclean II再次進行凝膠純化。將可即進行稼接之樣本重新懸浮於10微升之dH 〇中。就 pMON32322而言，將20微升之樣本，在5〇微升之反應體積中，以各20 U之Ncol/Hindlll，在37°C下進行3小時之切割處理。加入〇·1體積之3MNaOAc (pH5_5)及2.5體積之EtOH，混合，並於 -20 C下隔夜貯存。在4°C下，於Sigma Ml 202微離心機中，以 13,000 rpm離心20分鐘沈殿回收DNA。以冰70% EtOH沖洗DNA 沈殿物，凍乾，並重新懸浮於10微升之dH20中。實例92 使用另一方法建構pMON3232〇 (39/40斷裂點，I5胺基酸連接鲁子）、PMON32323 (65/66斷裂點，15胺基酸連接子）、及 PMON32324 (65/66斷裂點，10胺基酸連接子）。設計新引子 (L15C、L15D、L15E)，以於引子中納入符合閱讀框構之BamHI 限制位點，以使其可被選殖進入BamHI位點中，並維持恰當之閱讀框構。第一步驟之PCR反應條件與上述pMON32322者相同，惟使用下列之引子對：65For/L15D及65Rev/L15E (pMON32324) ; 39For/L15D及 39ReWL15C (pMON32320);及 65For/L15D及65Rev/L15C (pMON32324)。如上所述使用 Wizard O:\92\92747.DOC - 355 - 200413407 PCRCleanUp套組純化PCR產物，並溶析於50微升之dH20中。以 NcoI/BamHI (39For/115D 及 54For/L15D)或 BamHI/Hindlll (39Rev/L15C、65Rev/L15C及65Rev/L15E)對樣本進行切割處理。如下進行限制切割·· 10微升之經純化PCR反應產物，3微升之10X通用限制緩衝溶液，15 U之Ncol或Hindlll，15 U之BamHI ，終反應體積為30微升。將限制反應物置於37°C下反應90分鐘，並於1.1% TAE瓊脂凝膠上，以Geneclean II純化PCR產物。將可即進行稼接之樣本重新懸浮於10微升之dH20中。 φ 在三向（pMON32320、pMON32323、或pMON32324)或雙向 (pMON32321、pMON32322、pMON32325、pMON32326、 PMON32327、及pMON32328)稼接反應中，使插入子與經 Ncol/Hindlll切割之pMON3977 (BHK哺乳動物表現載體）(其已經蝦鹼性磷酸酶（SAP)處理）進行稼接，稼接反應如下：在1〇微升之反應物中，將2.5微升之插入子（各2微升之pMON32320、 pMON32323、及pMON32324之引子對擴增物）加入50納克（ng) 之載體中，使用標準稼接條件進行反應。根據製造商建議之流 · 程，以2微升之各反應物轉形100微升之化學感受態DH5 α細胞 (Gibco/BRL)。將20微升及200微升之樣本，塗於含有5〇微克/ 毫升胺苄青黴素之LB培養平板上，並隔夜進行培養。挑取分離之集落，並使用QiagenDNA微製備套組，自50毫升之隔夜培養物製備DNA。以A460/A280之吸收值定量dnA，並在將1微克之樣本以Ncol/Hindlll限制核酸内切酶進行切割處理之後，以瓊脂凝膠電泳辨識正確之插入子大小。使用載體專一性之引子，利用自動螢光DNA定序儀model 373A (Perkin Elmer ABS)， O:\92\92747.DOC -356- 200413407 對含有預測大小插入子之樣本進行兩方向之定序。定序反應係在20微升之反應體積中，使用Perkin Elmer model 480 DNA熱循環儀中如下進行：結合1微克之樣板，3.2皮莫耳之引子，1 微升之 DMSO，9.5 微升之 Taq terminator dyedeoxy premix (Perkin Elmer ABI)，並對其進行25循環之下述定序擴增反應： 94°C 30秒，50°C黏連15秒，再接續60°C4分鐘之延伸循環。使用Centri_Sep(Princeton Separations)，根據製造商之建議流程純化樣本，凍乾，並用於進行序列分析。選擇含有預測胺基酸 φ 序列之樣本進行分析，並指名為pMONnumbers。實例93 使用類似用於建構pMON32320、pMON32323、及pMON32324 之方法，將第二連接子類型（SERGlyGlySerGly)X(其中x = 2或 3)引入兩含有39/40斷裂點之序列重排序列間（pMON32348及 PMON32350)。引子對如下所列：就PM0N32348而言，使用 339For2/339Rev3 及 339Rev2/339-10For3 之組合，而就 PMON32350而言，使用 339For2/339Rev3及339Rev2/339-15For3 φ 之組合，以創造三種PCR擴增產物。各個PCR擴增反應係如下設置：將各50皮莫耳之引子對，1〇微升之5X緩衝溶液B，5 U Taq聚合酶，加入1〇〇納克（ng)之熱變性pm〇N32320，並以dH20 加至45微升之終體積。先將反應物如上所述進行預置。於下列條件下進行15循環之擴增反應：94°C 1分鐘，接續70°C之黏連步驟2分鐘，以及72t之延伸3分鐘。於最後一循環後，再進行 7分鐘之單一 72°C延伸步驟。使用Wizard PCR Clean Up套組 (Promega)純化引子對 339For2/339Rev3、339Rev2/339_10For3 O:\92\92747.DOC -357 - 200413407 及339Rev2/339-15For2之PCR擴增產物，並溶析於50微升之 dH20中。339For2/339Rev3引子對之NcoI/BamHI切割處理係如下進行：將8微升之DNA樣板，在20微升之反應體積中，與各 10 U之Ncol及BamHI混合，置於37°c下90分鐘。使用Geneclean II直接純化流程純化經切割處理之產物，並將可即進行稼接之樣本重新懸浮於10微升之dH20中。339Rev2/339-10For3及 339Rev2/339-15For2擴增產物之限制切割處理及後續之純化處理皆與339For2/339Rev3擴增物所進行之處理相同，惟使用1〇 U 之Hindlll取代Ncol。進行標準之稼接反應，將50納克經 NcoI/HindIII/SAP處理，且經凝膠純化之pMON3977，0.5微升之 339For2/339Rev3擴增物，1 微升之 339Rev2/339-10For3 (pMON32348)或339Rev2/339-15For3 (pMON32350)擴增物，5 U 之T4 DNA稼接酶，及1微升之10X稼接酶緩衝溶液，於1〇微升之反應體積中，在室溫下進行60分鐘之反應。如上所述進行後續之步騾，以確認終產物DNA序列。實例94 自模式建構之樣板，將第三類型之連接子（其具有不同之 (GlyGlyGlySer)X重複基序）納入另一組之序列重排flt3受體促效劑中。此等連接子之長度為；6 AA連接子（GlyGlyGlySerGlyGly序列編號NO: 792)，7 AA連接子（GlyGlyGlySerGlyGlyGly 序列編號 ΝΟ··793)，10AA連接子（GlyGlyGlySerGlyGlyGlySerGlyGly 序列編號 NO: 794)，13 AA連接子（GlyGlyGlySerGlyGlyGlySerGlyGlyGly SerGly 序列編號NO: 795)，15 AA連接子（GlyGlyGlySerGlyGlyGly SerGlyGlyGlySerGlyGlyGly序列編號 NO: 796)，及 21 AA連接子 O:\92\92747.DOC - 358 - 200413407 (GlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGly 序列編號NO: 797)胺基酸殘基。此等模式樣板（其各含有一hfit3 之二元體，且該二元體係由獨特長度之含有BamHI之連接子分隔）係如下建構。利用PCR，使用配對引子及樣板pM〇N30238 ，以類似pMON32322所用之循環條件，建構六種中間質體樣板 FL3N、FL7N、FL11N、FL3C、FL4C、及FL10C。在每項反應中’其將各50皮莫耳之引子加入100納克（ng)之熱變性樣板中，並如pMON32322所述組裝反應。循環條件如下所列：7循環之 φ 94〇C 1分鐘，65°C 2分鐘，及72°C 2.5分鐘；再進行1〇循環之 9411分鐘，70°〇2分鐘，及72它2.5分鐘。最後進行一7分鐘之72°C延伸步驟以完成循環。用於建構各中間分子之引子對為 N-term/FLN3 (FL3N) ; N_term/FLN7 (FL7N) ; N-term/FLNll (FL11N) ; C-term/FLC3 (FL3C) ; C-term/FLC4 (FL4C);及 C-term/FLCIO (FL10C)。使用 Wizard PCR Clean Up 套組 (Promega)純化PCR擴增產物，並溶析於50微升之dH20中。如上所述以NcoI/BamHI切割處理第一次群（FL3N、FL7N、及 _ FL11N)之經純化DNA，以凝膠純化，並與經NcoI/BamHI/Sap 處理之pSE420載體DNA (Invitrogen)進行稼接。以同樣之方法建構第二次群（FL3C、FL4C、及FL10C)之中間樣板，惟使用 Hindlll取代Ncol。如上所述進行後續之步驟，以確認終產物 DNA序列。實例95 為製造最終之6種樣板，如上所述以NcoI/BamHI (FL3N、 FL7N、FL11N -第一次群）或BamHI/Hindlll (FL3C、FL4C、 O:\92\92747.DOC - 359 - 200413407 FL10C ·第二次群）對PSE420中之兩次群中間分子進行切割處理，並使用Geneclean II進行純化。在各項反應中，將取自各次群之一中間分子複製物與經NcoI/HindIII/SAP處理之 pMON3977進行稼接，並將其轉形進入DH5a細胞，其如前所述，並使用下列之組合，以產生特定之連接子長度：6 AA連接子（FL3N及FL3C)，7 AA連接子（FL3N及FL4C)，10 AA連接子 (FL7N及FL3C)，13 AA連接子（FL3N及FL10C)，15 AA連接子 (FL11N及FL4C)，及21 AA連接子（FL11N及FL10C)。自上述六 ^ 種組合之各一單一集落之50毫升隔夜培養物中製備DNA，以 Ncol/Hindlll限制分析分析正確之插入子大小，並以其作為樣板。使用引子對 39For/39Rev (39/40 斷裂點）；65For/65Rev (65/66斷裂點）；及90For/89Rev (89/90斷裂點），以如上述處理 PMON32322之方法，對各樣板進行PCR擴增，惟使用各75皮莫耳（pmol)之引子。如下修飾擴增條件：6循環之94°C 1分鐘， 70°C 2分鐘，72°C 2.5分鐘；再進行9循環之94°C 1分鐘，及 72°C 3分鐘。在最後一循環後，進行一 6分鐘之72°C終延伸步 · 騾，以對產物之完全延伸提供足夠之時間。如上所述使用 Wizard PCR Clean Up套組純化樣本，並以Ncol/Hindlll進行雙切割處理。再次使用Wizard PCR Clean Up套組純化此等擴增產物。此外，亦將所有六種39/40斷裂點之不同連接子長度之分子選殖進入經NcoI/HindIII/SAP處理之pMON3977，成為單一蛋白（pMON32365、pMON32366、pMON32367、pMON32368、 PMON32369、及pMON32370) °如上所述進行後續之步驟，以確認終產物DNA序列。 O:\92\92747.DOC -360 - 200413407 實例96 建構編碼由IL-3受體促效劑pMON13416 (WO 94/12638)，經由IgG2b連接子，連結天然之flt3配位體或序列重排之flt3受體促效劑（實例91-93)之多功能鑲嵌受體促效劑分子之基因。以 Ncol/Hindlll限制片段之形式，將含有目標序列重排flt3受體促效劑分子之插入子自母質體分離，並使其與經 Afllll/Hindlll/SAP切割處理之pMON30304進行稼接。如上所述進行後續之步騾，以確認終產物DNA序列。所得之質體示於表 9，此等質體含有編碼含IL-3受體促效劑（取自pMON13416者），以及序列重排flt3受體促效劑之多功能鑲嵌受體促效劑分子之DNA序列。

O:\92\92747.DOC -361 - 200413407 表9 所得質體 hflt3配位體變換前體 PMON30247 pMON30237 pMON30248 pMON30238 pMON32332 PMON32321 pMON32333 PMON32320 pMON32334 pMON32325 pMON32335 PMON32324 pMON32336 pMON32323 PMON32337 pMON32328 pMON32338 PMON32327 pMON32339 pMON32326 實例97 建構編碼由IL-3受體促效劑pMON13288 (WO 94/12638) ，經由IgG2b連接子，連結天然之flt3配位體或序列重排之 flt3受體促效劑（實例91-93)之多功能鑲嵌受體促效劑分子之基因。以Ncol/Hindlll限制片段之形式，將含有目標序列重排flt3受體促效劑分子之插入子自母質體分離，並使其與經Afllll/Hindlll/SAP切割處理之pMON303 1 1進行稼接。如上所述進行後續之步驟，以確認終產物DNA序列。所得之質體示於表1 0，此等質體含有編碼含IL-3受體促效劑（取自 PMON13288者），以及序列重排flt3受體促效劑之多功能鑲嵌受體促效劑分子之DNA序列。 O:\92\92747.DOC -362- 表10 所得質體 hflt3配位體前體 PMON32364 PMON30237 pMON32377 pMON30238 pMON32352 PMON32321 pMON32353 PMON32320 pMON32354 pMON32325 pMON32355 pMON32324 pMON32356 PMON32323 PMON32357 PMON32328 PMON32358 pMON32327 pMON32359 pMON32326 PMON32360 pMON32348 PMON32362 PMON32350 pMON32396 PMON30239 實例98 200413407 經由PCR，使用pMON32360及pMON32362質體DNA作為樣板，並使用引子對N-term/134rev及N-term/139rev建構兩種於該鑲嵌分子之N-端具有序列重排flt3受體促效劑組成份之鑲嵌分子，以使用符合閱讀框構之SnaBI限制位點，取代天然flt3配位體分子C-端之終止密碼子。反應混合物如上述pM〇N32322之反應混合物設置。循環條件如下所列：7 循環之94°C 1分鐘，65°C 2分鐘，及72°C 2 1/2分鐘；再進行10循環之擴增，惟黏連溫度自65 °C提高為70 °C。使用 O:\92\92747.DOC - 363 - 200413407

Wizard PCR Clean Up套組及流程純化樣本，並溶析於50微升之dH20中。以Ncol及SnaBI對20微升之各樣本進行切割處理。以Ncol及SnaBI切割處理質體pMON2643 1之DNA，並使其與經NcoI/SaBI切割之PCR反應物進行稼接。如上所述進行感受態DH5 α細胞之轉形，以及後續確認終產物DNA序列之步驟。實例99 如上所述使用特定之引子28/29 (28For/28Rev)、34/35 (34For/34Rev)、62/63 (62For/62Rev)、94/95 (94For/94Rev) 、及98/99 (98For/98Rev)擴增10及15胺基酸連接子 (GlyGlyGlySer)x，製備另外五種hflt3配位體斷裂點。如前所述以Ncol/Hindlll切割處理所得之PCR產物，並將其稼接進入經Afllll/Hindlll/SAP切割之pMON303 1 1中。如上所述進行感受態DH5 α細胞之轉形，以及後續確認終產物DNA 序列之步驟。實例100 為獲得序列重排hflt3受體促效劑於大腸桿菌中之較高表現，使用編碼簡併密碼子之N-端專一性引子，以重新對大腸桿菌表現載體PMON5723中之1-134及1-139形式hflt3配位體進行人工改造處理。使用引子對FH3AFor/SCF.rev (Ala2)及Flt23For/SCF (Gly2)，以對編碼天然flt3配位體之序列之N-端簡併混合物進行PCR擴增，其使用如 PMON23222所用之反應條件，惟將擴增循環之數目減少為 15循環之95°C 1分鐘，55°C 2分鐘，及72°C 2 1/2分鐘。 O:\92\92747.DOC -364 - 200413407 使用\¥丨23『(^€11(^卜3111；|3套組（？1'〇则§3)純化擴增物，並溶析於50微升之dH20中。如前所述以Ncol/Hindlll進行限制切割處理，併使用Genecleanll進行凝膠純化。如前所述使插入子與經NcoI/HindIII/SAP處理，並經凝膠純化之 PMON5723質體DNA進行稼接，並使其轉形進入感受態DH5 α細胞中。將各經轉形細胞之部分樣本塗於含有乃微克/毫升壯觀黴素之LB瓊脂培養基培養平板上，置於37艺下14 -16 小時’並對集落進行計數。在確認集落之後，將各剩餘之轉形混合物置於含有75微克/毫升壯觀黴素之2 χ 5毫升之 LB培養基中，在3 7 °C下進行隔夜培養（14-1 6小時）。使用 Wizard DNA 373A Miniprep 套組（promega)，根據建議流程 ’製備微製備DNA。將微製備DNA溶析於50微升之dH20中 ’並使用1 -2微升對感受態MON207細胞進行化學轉形。將 25及200微升之樣本塗於含有75微克/毫升壯觀黴素之[；6培養基培養平板上，並置於37艽下12-15小時。選擇代表各原始引子對之40-50個清楚分離之集落，於lb/壯觀黴素主培養平板上進行劃線，並於37它下再放置4-6小時。以96孔微滴足模式，對各序列重排hflt3受體促效劑純系之大腸桿菌表現進行篩選，以選擇較高之表現程度。在每一孔中，於 100微升之基本M9培養基（包括1%之水解酪蛋白胺基酸）置入一單一純系（每一 hflt3 PCR引子對分析4〇-5〇個分離純系） ’並在200 1；_下，將其置於37t：下3_4小時（1==〇)，且加入$ 微升/孔之1毫克/毫升新鮮製備之奈啶酮酸（於〇.l N Na〇H 中）以進行誘發。在37χ；下放置另外4小時後（1=4)，自各孔

O:\92\92747.DOC - 365 - 200413407 中抽取約5-10微升之樣本，並以光學顯微鏡分析折射體之存在，以含有折射體之細胞數對總細胞數之大約百分比對結果進行評分。選擇具有最高表現程度之集落，如下進行 10耄升之桌面規模表現研究。使5毫升之隔夜培養物於lB 私養基中，於75微克/毫升壯觀黴素之存在下，在37。〇下進仃生長。在125毫升搖瓶内之10毫升新鮮製備之基本M9培養基（含有1 %之水解酪蛋白胺基酸）中，接種足量之隔夜培養物，以達成2〇Klett單位之起始測讀值，隨後將其置於” C下震盥培養約3_4小時，直到達成約11〇_i5〇單元之密度（1=0)，並以50微升新鮮製備之奈啶酮酸（1〇毫克/毫升，於〇·1 N NaOH中）進行謗發。取出丨毫升之樣本，並微離心1分鐘以沈澱細胞。移除上清液，並將沈澱物貯存於_2〇 c下，直到預備進行SDS_PAGE分析。再將剩餘之經誘發細胞於37 C下震盪培養另外4小時，在此時間點後（1=4广測量細胞始度（尺4«單位）。自每一樣本中取出i毫升之試樣，沈澱細胞，並如上所述進行貯存。自每一瓶中取出另外5_1〇微升之試樣，並以光學顯微鏡分析折射體之存在。將經沈澱之樣本重新懸浮於與卜4 Klett值相等之丨體積（微升單位 )2X荷載緩衝溶液（包括！％之万_琉基乙醇），煮沸$分鐘，並將6-7微升加至12%或14%三_甘胺酸SDS聚丙晞醯胺凝膠 (Novex)，以90伏特進行電泳9〇分鐘。根據建議之流程 (Novex)，對該凝膠進行固定，染色，並預備進行乾燥。此時，根據相當於預測大小之單一經謗發蛋白條帶（ι = 4)相較於1=0樣本之較高表現程度選擇純系，以進行放大醱酵。亦 O:\92\92747.DOC -366 - 200413407 如上所述自表現高濃度經謗發蛋白之經選擇純系製備微製備DNA，並如上所述進行確認終產物DNA序列之步驟。此等純系稱為 pMON32329、pMON32330、pMON32341、及 pMON32342 ° 實例101 亦建構一組含有IL-3受體促效劑（取自PMON13288者）及天然flt3配位體之多功能受體促效劑鑲後分子，以於大腸桿菌中進行表現。 | 如上所述，以Ncol/Hindlll對母載體進行切割處理，以將編碼取自pMON32364及pMON32377之多功能受體促效劑鑲嵌分子釋出，並挑取單一分離純系。此等建構稱為 pM〇N32394 (插入子取自 pMON32364)及pMON32395 (插入子取自 PMON32377)。實例102 使用50皮莫耳之引子FLTAFLS1及FLTR1N，並使用約10 納克（ng)之質體pMON27184作為樣板，以一 1.4 Kb PCR產泰物之形式，分離經截短之Flt3受體。此等引子之設計使其可於®比鄰成熟編碼序列之第一 Asn密碼子之5f處，產生一 Afllll限制位點，並於毗鄰推定之跨膜區域之5’處，產生一 EcoRI限制位點。使用標準之反應條件，以Afllll及EcoRI 對反應物進行切割處理，並使其稼接進入經NcoI/EcoRI切割之質體PMON26458中。此一質體含有下列之DNA序列： 5?-GGATCCACCATGAGCCGCCTGCCCGTCCTGCTCCTGC TCCAACTCCTGGTCCGCCCCGCCATGGCTAAAGCTT-3’序 O:\92\92747.DOC -367 - 200413407 列編號NO: 857，其編碼IL-3信號序列。此一序列於5f端含有一 BamHI限制位點，且包括ATG甲硫胺酸作為其位於該 BarnHI位點之3’側之信號序列之第一胺基酸。此一信號序歹ij 可由細胞切除，留下5’之Met/Ala，其係藉由融合取自信號序列之Ncol位點以及由PCR反應製備之受體上之Afllll位點而產生。該受體之整個經截短形式以及該IL-3信號序列可再以BamHI/EcoRI切割物（hIL3L/hFlt3R)之形式自載體切出。 · 如下所述對pMON30298 (hG-CSFR)之催化域進行再改造，以經由PCR，於跨膜/胞質連結點之位置，創造一符合閱讀框構之EcoRI限制位點。如前所述，於0.5微克之熱變性 pMON30298中，加入各100皮莫耳之引子HGCFfor及 HGCFrev，10微升之5X缓衝溶液J，5U之丁 aq聚合酶，以及 dH20，使終體積到達45微升。如下完成PCR擴增反應：6循環（94°C 1分鐘，64°C 2分鐘，及70°C 3分鐘），接續9循環 (94°C 1分鐘，70°C 4分鐘）。最後再於70°C進行7分鐘之終 _ 延伸反應。如前所述，使用Geneclean II，對10微升之各PCR 反應物進行凝膠純化，並溶析於10微升之dH20中。以各10 U之EcoRI及Hindlll，在20微升之反應物中，於37°C下，對樣本進行90分鐘之切割處理。如上所述再次對樣本進行凝膠純化（Geneclean II)，並溶析於10微升之dH20中。如上所述，在10微升之反應物中，使2微升之插入子與50納克經 Ncol/Hindlll/磷酸酶處理之pSE420載體進行稼接。如上所述進行感受態DH5 α細胞之轉形，以及後續確認終產物 O:\92\92747.DOC - 368 - 200413407 DNA序列之步驟。再對經篩選之純系進行定序，以辨認該符合閱讀框構EcoRI位點之存在，並確認正確之G-CSFR催化域DNA序列。如上所述以EcoRI/Hindlll對含有預測序列之純系進行切割處理，並以凝膠純化。使經純化之hG_CSFR (EcoRI/Hindlll)及 hIL3L/hFlt3R (BamHI/EcoRI)片段插入子，與經BamHI/Hindlll/磷酸酶處理之pcDNA 3·1 (-)載體 (Invitrogen)進行稼接。如上所述進行感受態DH5 α細胞之轉形，以及後續確認終產物DNA序列之步騾。實例103 如前所述，使用二元體樣板中間物，建構其他編碼序列重排Flt3配位體之基因。就具有15胺基酸連接子 (GlyGlyGlySer)3GlyGlyGly 序列編號 NO: 795之序列重排 Flt3受體促效劑而言，其使用二元體中間物Flt4C.seq及 FltllN.seq作為樣板。如述於實例94者，以基於PCR之方法，使用PCR Optimizer套組（Invitrogen)以及下列之引子對，建構對應於FU3配位體胺基酸殘基28/29、34/35、62/63、 94/95 、及 98/99 之斷裂點：FL29For/FL29Rev 、 FL35For/FL35Rev、FL63For/FL63Rev、FL95For/FL95Rev 、FL99For/FL99Rev。擴增條件如下：7循環之94°C 1分鐘，62°C 2分鐘，及70°C 2.5分鐘；12循環之94°〇 1分鐘， 68〇C 2分鐘，及70°C 2.5分鐘；接續70°C 7分鐘之終循環。以Ncol及Hindlll，對相對於預測插入子大小之PCR產物進行切割處理，並如前所述使用Gene Clean II (Bio 101)，根據製造商之建議流程進行凝膠純化。將樣本以dH20重新 O:\92\92747.DOC -369- 200413407 懸浮於10微升之終體積中。以單一基因之形式，將插入子選殖進入哺乳動物表現載體ΡΜΟΝ3934中（經 NcoI/HindIII/SAP 處理），並分別稱為 pMON35712、 pMON35713、pMON35714、pMON35715、pM〇N35716、 pMON35717、及pMON3571 8。將 28/29、34/3 5、62/63、94/95、及 98/99斷裂點引子對之經純化、限制切割之PCR產物，選殖進入經 Afllll/Hindlll/SAP處理之pMON3031 1中，以製備編碼含有 IL-3受體促效劑（其由pMON13288 (WO 94/12638)編碼，於此以「IL-3受體促效劑I」表示），以及序列重排Flt3配位體之鑲嵌蛋白之基因。所得之質體分別稱為pMON32398、 pMON35700、pMON35702、pMON35704、及 pMON35706 。此外，使用同樣之引子對，結合二元體樣板中間物 Flt7N.seq及Flt3C.seq，以分別製備此等IL-3受體促效劑 I/Flt3L鑲嵌蛋白之10胺基酸連接子（GlyGlyGlySer) 2GlyGly(序列編號NO: 793)形式；pMON32397、pMON32399 、pMON35701、pMON35703、及pMON35705 ° 實例104 以類似之PCR方法，使用二元體樣板中間物FitllN.seq及 Fit lOC.seq，以及下列之引子對，建構編碼含有21胺基酸殘基連接子（GlyGlyGlySer)5Gly (序列編號NO: 796)之IL-3受體促效劑I/FU3L鑲嵌蛋白之基因；Flt36/36Rev、Flt37/37Rev 、Flt38/38Rev、Flt39/39Rev、Flt41/41Rev、Flt42/42Rev、及Flt43/43Rev。此等引子對相對應於下列之Flt3配位體斷 O:\92\92747.DOC -370- 200413407 裂點 35/36; 3 6/37; 37/3 8; 38/3 9; 40/41; 41/42;及 42/43 (3 9/40 斷裂點已於前述以pM〇N32376製備）；並用於進行使用下列循環條件之PCR擴增反應：7循環之94°C 1分鐘，66°C 2分鐘’及70。〇 2.5分鐘；15循環之94。〇 1分鐘，及70X： 4分鐘；接續72 °C 7分鐘之終循環，使用Invitrogen PCR Optimizer套組（緩衝溶液B)。在dnA序列之確認後，將此等建構分別命名為 pM〇N53733、pMON35734、pMON35735、 pMON35736、pMON35738、pMON35739、pMON35740、 pMON3574l、pMON35742、及pMON35743。PCR納入之錯誤造成兩種序列重排Flt3鑲嵌配對物之單一胺基酸取代物 (pMON3574l，35/36 斷裂點；以及pMON35743，42/43 斷裂點），並產生一種建構（?)^1(^3 5742,3 8/3 9斷裂點），其含有 Flt3L部分中之Q133至R133及Q100至R100,及L112至P112之兩種氨基酸取代’其作為此一系列之部分進行建構及試驗。亦使用1 5胺基酸連接子（GlyGlyGlySei〇3GlyGlyGly，樣板 Flt4C及FLtllN，建構其他Flt3L/IL-3受體促效劑I鑲嵌蛋白 ’此等鑲欲蛋白中含有對應前述Flt3配位體胺基酸殘基 28/29、34/35、62/63、65/66、89/90、94/95、及 98/99之不同Flt3L斷裂點。PCR反應混合物類似述於實例103中者，惟對編碼序列重排Flt3部分C-端之反向引子進行修飾，以 SnaBI辨識序列取代Hindlll限制位點。PCR擴增循環參數如下· 7循5哀之94〇 1分鐘’ 66C 2分鐘，及70°C 2.5分鐘； 14循環之94°C 1分鐘，及70°C 4分鐘；接續72°C 7分鐘之終循環。如前所述進行PCR清除、限制切割處理、及純化 O:\92\92747.DOC -371- 200413407 。如下所述使插入子與經NcoI/SnaBI/SAP處理之 pMON26431 (含有IgG2b連接子/IL-3受體促效劑I部分之 BHK表現載體）：在1〇微升之反應體積中，加入50納克之經處理載體、插入子（10 : 1插入子：載體）、1單位之T4 DNA 稼接酶（GibcoBRL)、及1微升之10X稼接酶緩衝溶液。在室溫下放置1小時以進行稼接反應，然後各取出2微升之稼接反應物，並將其根據製造商之建議流程用於轉形1 〇〇微升之化學感受態DH10B (或是DH5 α )細胞（Gibco BRL)。將各轉 · 形混合物之五分之一及二十五分之一塗覆於添加適當抗生素標記物之LB瓊脂培養平板上，並隔夜（14-16小時）置於37 t下。挑取分離之群落，並如上所述使用Qiagen微製備流程製備DNA。經挑選純系之序列分析確認了 28/29斷裂點（pMON35719) 、34/35斷裂點（pMON35720)、62/63斷裂點（pMON35721)、 65/66 斷裂點（pMON35722)、89/90 斷裂點（pMON35723)、及 98/99斷裂點（pMON35725)。pMON35726含有 94/95斷裂點之 _ 單一胺基酸取代（Leu94至Phe94)。具有39/40之Flt3L斷裂點，以及10、15、及21 AA之不同胺基酸連接子長度之 Flt3L/IL-3受體促效劑I鑲嵌建構可由pMON35707、 pM〇N35708、pMON35709、pMON35710、及 pMON3571 1 代表。此等建構係由下列樣板之一：PMON32373、 pMON32375、或pM〇N32376，以及專一性引子對39N TERM-1/SN ABIC TERM之PCR擴增產生。如前所述配製標準之PCR反應混合物，並使用下列參數擴增PCR產物：7循 O:\92\92747.DOC -372 - 200413407 環之94^：1分鐘，62°〇2分鐘，及70°〔2.5分鐘；12循環之94°C 1分鐘，68°〇2分鐘，及70它2.5分鐘；接續72°〇7 分鐘之終循環。以Ncol及SnaBI，對相對於預測插入子大小之PCR產物進行切割處理，以凝膠純化之，並如前所述將其選殖進入哺乳動物表現載體pMON26431中（經 NcoI/SnaBI/SAP處理），成為 Flt3L/IgG2b/IL-3 受體促效劑 I 鑲嵌蛋白。此等建構中之兩者在序列重排Flt3鑲嵌配對物中含有PCR納入之錯誤，其造成F96至L96，以及E58至G58之單一胺基酸取代（PMON3 5710及pMON3571 1)。實例105 亦使用經選擇之IL-3受體促效劑1/序列重排FU3L建構作為樣板（參見下表11)，建構另一系列之鑲嵌蛋白，具有前述之 35/36、36/37、38/39、40/41、41/42、42/43、及 65/66斷裂點，以及21胺基酸連接子之序列重排Flt3L/IL-3受體促效劑I。唯一之例外為使用15胺基酸連接子樣板（pMON3 5715) 以建構65/66斷裂點，pMON35771。 O:\92\92747.DOC - 373 - 200413407 表11

Flt3L/IL-3受體促效劑I IL-3受體促效劑I/FU3L

建構樣板 Flt3L 引子對斷裂點 PMON35744 pMON35733 35/36 Flt36/36Revf pMON35745 pMON35734 36/37 Flt37/37Rev, PMON35746 pMON35735 37/38 Flt38/38Revf pMON35747 pMON35736 38/39 Flt39/39Rev' PMON35748 PMON35738 40/41 Flt41/41Revf PMON35749 pMON35739 41/42 Flt42/42Rev’ PMON35750 pMON35740 42/43 Flt43/43Revf PMON35769 pMON35743 42/43 Flt43/43Revf PMON35771 pMON35715 65/66 65For/66SnaBI 使用編碼與用於建構pMON35719-35725者相同之限制位點之引子對。使用反向引子36 Rev1、37 Rev’、38 ReV、39 Rev’、41 Rev’、42 Rev’、及43 Rev’，以創造符合閱讀框構之SnaBI位點。使用同樣之正向引子Flt36、Flt37、Flt38、

Flt39、Flt41、Flt42、及Flt43。PCR反應混合物與前述相同，然而，除pMON35771外，擴增條件如下進行修飾：18循鲁環之94°〇1分鐘，68°〇2分鐘，及70°。2.5分鐘；接續70 t： 7分鐘之單一延伸循環。就pMON335771而言，擴增條件如下·· 6循環之94°C 1分鐘，66°C 2分鐘，及70°C 2.5 分鐘；15循環之94°C 1分鐘，及70°C 4分鐘；接續72°C 7 分鐘之終循環。如實例104中所述，對此等Flt3-專一性PCR 產物進行限制切割，純化，並將其選殖進入pMON2643 1中（含有IgG2b連接子/IL-3受體促效劑I部分之BHK表現載體）。使用PCR引子對Flt4〇/34Rev，及二元體樣板中間物 O:\92\92747.DOC -374- 200413407

Fltl IN.seq及FltlOC.seq，以34/40斷裂點之形式建構變體 PMON3 2179。PCR擴增條件及後續之選殖皆與用於選殖 PMON3 5771者相同。設計並建構另外三種Flt3L/IL-3受體促效劑I鑲嵌物（38/39斷裂點），以試驗不同連接子長度及組成之效應。使用PMON35709作為樣板，GlySer連接子之長度延伸為涵括具有基序（GlyGlyGlySer)7Gly之29胺基酸殘基，使用引子對BamForl/38Rev (反應產物稱為PCR A)及 Flt38/BamRevl (反應產物稱為PCR B)。擴增條件如下：6 循環之94°(：1分鐘，66°〇2分鐘，及70。〇2.5分鐘；15循環之94°C 1分鐘，及70°C 4分鐘；接續72t 7分鐘之終循環。使用Promega PCR clean up套組清除所得之PCR產物，以 NcoI/BamHI (PCR A)或 BamHI/SnaBI (PCR B)進行切割處理，以凝膠純化，並如前所述使其與pMON26431 (含有 IgG2b連接子/IL-3受體促效劑I部分之BHK表現載體）進行稼接。對所得之建構進行定序確認，並命名為pMON35774 。比較而言，PMON35775及pMON35776之不同處為其GlySer 連接子被含有一單一胺基酸取代之天然Flt3L胺基酸殘基 140-154 (pMON35775)或 140-160 (pMON35776)取代。PCR 反應條件與PMON35774所述者相同，惟使用下列引子對： 38For/Navfor 及 38Rev/NavRevS (pMON35775)；以及 3 8For/Navfor及 3 8Rev/NavRevL (pMON3 5 776) 〇以 KasI取代 BamHI，此等PCR擴增產物之其餘選殖步騾皆與 pMON35774所用者相同。序列分析顯示PCR在pMON35775 及pMON35776兩者之多種分離物中引入錯誤。為取得最終 O:\92\92747.DOC -375 - 200413407 之正確序列，必需以Narl/SnaBI及Ncol/Narl對經選擇之次純系進行再切割，並使用此等凝膠純化之片段重新選殖目標建構。亦建構數種Flt3L二元體鑲嵌分子，以作為BHK瞬時物進行測試。PMON32173 (其係尤以IgG2b連接子連結之兩天然Flt3L分子構成）係由兩種既存之分子如下組裝而成 :將取自pMON32393之含有Flt3L之NcoI/SnaBI插入子，與經凝膠純化，並經NcoI/SnaBI切割之pMON32377 (其中IL-3 受體促效劑I鑲嵌配對物已被釋出）進行稼接。同樣， pMON35727 (39/40斷裂點，15胺基酸連接子）係使取自 pMON3 5 708之Flt3L插入子（作為一NcoI/SnaBI插入子），與經凝膠純化之PMON323 75 (其中IL-3受體促效劑I鑲嵌配對物已被切除）進行稼接而組裝。第三種Flt3L二元體 pMON3 2 168 (3 9/40斷裂點，21胺基酸連接子）係如下組裝：將取自pMON3 2165 (pMON3 5709之大腸桿菌當量物其係藉由將取自 pMON32163 之 NcoI/BamHI 片段及 pMON35709之 BamHI/Hindlll片段次選殖進入經Ncol/Hindlll切割之 pMON5723中組裝）之NcoI/SnaBI插入子。將取自 PMON32165 之 NcoI/SnaBI 插入子（Flt3L 1-139 (39/40) L21) 及取自 pMON32376 之 SnaBI/Hindlll 插入子（IgG2b/Flt3L 1-139 (39/40) L21)次選殖進入大腸桿菌生產載體 pMON5723 中，即產生pMON32167。再將取自 pMON32167 之Ncol/Hindlll插入子次選殖進入PMON3 0304，並將其命名為 pMON32168。實例106 O:\92\92747.DOC - 376 - 200413407 亦自既存之分子，使用經限制切割及凝膠純化之片段，建構一系列之三元體分子，各含有兩個FU3L部分及單一拷貝之IL-3受體促效劑I或IL-3受體促效劑II (由pMON13416 (WO 94/12638)編碼之IL-3受體促效劑，其於此以「IL-3受體促效劑II」代表）。使用取自pMON32375之NcoI/EcoRI (Flt3L/IgG2b/IL-3受體促效劑I)插入子，以及取自 pMON35708 之 EcoRI/Hindlll (IL-3 受體促效劑 I/IgG2b/Flt3L)插入子，組裝pMON35728。再將該兩片段與 φ 經NcoI/HindIII/SAP處理之哺乳動物表現載體ρΜΟΝ3934進行再稼接，並如前所述進行次選殖。pMON32205 (IL-3受體促效劑 II/IgG2b/Flt3 l-139/IgG2b/Flt3 1-139)係將取自 PMON32173 之 Ncol/Hindlll 片段稼接近入 pMON30304 之 Afllll/Hindlll位點而組裝。使用類似之方法建構 pMON32206 (IL-3 受體促效劑 II/IgG2b/Flt3L (39/40) L21/IgG2b/Flt3L (39/40) L21)。將取自 pMON32167 之 Ncol/Hindlll片段以凝膠純化，並次選殖進入經 φ Afllll/Hindlll切割之ρΜΟΝ3 03 04中（其含有IL-3受體促效劑 II/IgG2b-部分）。質體 pMON32207 (Flt3L (39/40) L21/IgG2b/Flt3L (39/40) L21/G-CSF)係將取自 pMON32170 之凝膠純化Ncol/Hindlll插入子次選殖進入中間物 pMON32198 (Afllll/Hindlll)中而組裝。 pMON32208 (Flt3L 1 -13 9/IgG2b/G-CSF/IgG2b/Flt3L 1-139)係將取自卩^^€^30320之凝膠純化81^31插入子（作為 IgG2b/G-CSF)次選殖進入經SnaBI切割/經SAP處理之 O:\92\92747.DOC -377- 200413407 pMON3 2173 中而組裝。pMON3 2204係將取自 pMON32173之 Ncol/Hindlll插入子次選殖進入經Afllll/Hindlll切割之 pMON30309 中（其含有 G-CSF/IgG2b)而組裝。pMON32195 (Flt3L 1-139 (39/40) L2 l/IgG2b/G-CSF /Flt3L 1-139 (39/40) L21)係將取自pMON32190之NcoI/SacI插入子及取自 pMON32171 之 Sacl/Hindlll 片段次選殖進入經 Ncol/Hindlll 切割之 pMON30304 中而建構。pMON32196(G-CSF/IgG2b /Flt3L 1-139 (39/40) L21/IgG2b/Flt3L 1-139)係將取自 pMON3 03 09之 Ncol/Afllll片段（呈 G_CSF/IgG2b形式）次選殖進入經 NcoI/SAP 處理之 pMON32168 (Flt3L 1-139 (39/40) L21/IgG2b/Flt3L 1 -1 39)而組裝，並以DNA序列及限制分析確認排列方向。pMON32197 (G-CSF/IgG2b/Flt3L 1-139 (39/40) L21/IgG2b/Flt3L 1-139 (39/40) L21)係將 pMON32167 之 Ncol/Hindlll 插入子（Flt3L 1-139 (39/40) L21/IgG2b/Flt3L 1-139 (39/40) L21)次選殖進入 pMON30309 (G-CSF/IgG2b)之 Afllll/Hindlll位點而建構。實例108 以G-CSF取代IL-3受體促效劑I或IL-3受體促效劑II作為鑲嵌配對物，以建構一系列含Flt3L之分子作為BHK瞬時物。就瞬時表現，並使用BHK載體pMON3934製備之鑲嵌蛋白而言，G-CSF部分於第17位可編碼Ser或Cys。就用於進行大腸桿菌表現，或用於在哺乳動物表現系統中進行非瞬時表現之分子而言，G-CSF配對物之第17位全部編碼Ser。以兩種排列方向，將天然Flt3L及G-CSF之鑲嵌物以BHK表現建 O:\92\92747.DOC - 378 - 200413407 構之形式製備：G_CSF/IgG2b/Flt3L (pMON30329)及 Flt3L/IgG2b/G-CSF (pMON32175)。pMON30329係將取自 pMON3 0328之Flt3Ll-139插入子（呈NcoI/HindIII切割物形式）次選殖進入經Afllll/Hindlll切割處理之pMON30309 (其含有G-CSF/IgG2b)中而組裝，而pMON32175則係使取自 pMON32393之凝膠純化NcoI/SnaBI插入子，與經 NcoI/SnaBI切割處理之pMON26420 (其含有 IgG2b/G-CSF基因）進行稼接而建構。第三天然G-CSF/Flt3L鑲嵌分子 PMON32191與pMON32175之不同處在於其具有取代IgG2b 鑲嵌連接子之GlySer連接子，且其係設計用以進行大腸桿菌表現者。使用取自PMON32393之相同凝膠純化 NcoI/SnaBI插入子，插入經NcoI/SnaBI切割處理之 PMON3 1123 (其含有GlySer/G-CSF基因）而組裝 PMON23191 。其BHK當量物pMON35767係將取自 PMON32191之凝膠純化Ncol/Hindlll鑲嵌基因次選殖進入 BHK載體pMON3 934中而組裝。實例109 以G-CSF取代IL-3受體促效劑I，以建構兩系列之序列重排Flt3L鑲嵌物。第一組（具有G-CSF/IgG2b/序列重排Flt3L 之排列方向）基本上係如下進行組裝：以SnaBI/Hindlll切割處理 pMON30329 (G-CSF/IgG2b/Flt3L 1-139)，並如上所述以凝膠純化含有載體之G-CSF部分。再將示於下表12中之取自適當之IL-3受體促效劑I/Flt3L建構之經 SnaBI/Hindlll切割處理之插入子次選殖進入pM〇N30329中 O:\92\92747.DOC - 379 - 200413407 (SnaBI/Hindlll)。表12 G-CSF/IgG2b/Flt3L建構及其IL-3受體促效劑I類似物

Flt3L斷裂點 pMON(G-CSF) DMONiIL-3 受體促效劍I) 35/36 L21 pMON32188 pMON35733 89/90 L21 pMON32273 pMON32389 37/38 L21 pMON35795 pMON35735 38/39 L21 pMON35796 pM〇N35736 40/41 L21 pMON35797 pMON35738 41/42 L21 pMON35798 pMON35739 42/43 L21 pMON35799 pMON35740 pMON32169 (G-CSF/IgG2b/Flt3L 1-139 (29/40) L21)係將取自 pMON32163 之 NCoI/BamHI插入子及取自 pMON32370 之BamHI/Hindlll插入子次選殖進入經Afllll/Hindlll切割處理之pMON3 03 09中組裝。此一系列中之三種分子不具有直接之IL-3受體促效劑I對等物。第一分子pMON3 9914係使用鲁經Afllll/Hindlll切割處理之BHK表現載體pMON30309 (其含有 G-CSF/IgG2b)，以及取自 pMON32243 之 Flt3 1-139 (39/40) L29插入子（呈Ncol/Hindlll形式）而組裝。就 PMON39915 而言，其係將取自 pMON32242 之 Flt3L 1-154 (39/40)基因（呈Ncol/Hindlll插入子形式）次選殖進入母載體 PMON30309中。pM〇N39916係完全如pM〇N3991 5般組裝，惟使用取自PMON32252之Flt3L 1 -1 60 (39/40)插入子。 pMON3 2242、32243、及32252係大腸桿菌表現建構，其含 O:\92\92747.DOC -380 - 200413407 有非鑲嵌性，序列重排之Flt3L基因（呈Ncol/Hindlll形式）。最後，將取自PMON35799之插入子次選殖進入pMON5723 中（以NcoI/HHindlll片段形式），以在大腸桿菌中進行表現。此一大腸桿菌生產質體命名為PMON39904。實例110 亦自下表13所指明之IL-3受體促效劑I類似物，建構許多具有排列方向Flt3L/IgG2b/G-CSF之第二系列G-CSF鑲嵌物。表13

Flt3L/IgG2b/G -CSF建構及其IL-3受體促效劑I類似物 Flt3L斷裂點 pMONiG-CSF) dMON(IL-3 受體促效劑I) 39/40 L10 pMON3575 1 pMON35707 39/40 L15 pMON35752 pMON35708 39/40 L21 pMON35753 pMON35709 89/90 L15 pMON35754 pMON35723 35/36 L21 pMON35755 pMON35744 36/37 L21 pMON35756 pMON35745 37/38 L21 pMON35757 pMON35746 34/35 L15 pMON35759 pMON35720 65/66 L15 pM〇N35760 pMON35722 98/99 L15 pMON35765 pMON35725 此等建構係使用經NcoI/SnaBI切割處理之pMON361 含有IgG2b/G-CSF基因之BHK載體），以及取自上表所示之 O:\92\92747.DOC -381 - 200413407 FU3L/IL-3受體促效劑I鑲嵌蛋白之特定序列重排Flt3L插入子（經NcoI/SnaBI切割處理）。所得之質體命名為pMON32170 、pMON32871、pMON32271、、pMON3575 1、pMON35752、 PMON32172、 PMON35753、 pMON32174 pMON35754 、pMON35755、、PMON35759、、pM〇N35763、、PMON35767、、pMON35773、、pMON35780、 pMON35756 pMON35760、 pMON35764、 pMON35768、 PMON35777、 pMON35757、pMON35758 PMON35761、 pMON35765 > pMON35770、 pMON35778、 pMON35762 PMON35766 pMON35772 pMON35779

pMON35782、及pMON39908 〇 PMON3 5 777及pMON3 5 778係以PCR建構，並自述於

PMON3 5 775及pMON3 5776之相同 Ncol/Narl及Narl/SnaBI插入子組裝，惟使用經NcoI/SnaBI切割處理之pMON3575 1作為含有IgG2b/G-CSF基因之母載體。為建構pMON35778之 3 9/40斷裂點當量物，使用引子對？1140/81^31€461'111重新擴增PMON35778樣板。擴增條件如前pMON35771所述者進行，惟將起始Tanneal由66降至55°C。所得之建構命名為 pMON35782 (Flt3 1-160 (39/40)/IgG2b/G-CSF) ° pMON32170 (Flt3L 1-139 (39/40) L21/IgG2b/G-CSF)係將取自pMON32165之NcoI/SnaBI插入子稼接進入經 NcoI/SnaBI 切割處理之 pMON26430 (其含有 IgG2b/G-CSF) 中而組裝。pMON35764 (FU3L (38/39) L21/IgG2b/G-CSF) 係如下進行選殖：使用pMON3 5 73 6作為樣板，並使用引子對Flt39/39Rev，對序列重排之FH3L插入子進行PCR擴增。 O:\92\92747.DOC -382 - 200413407 擴增條件與pMON3 577 1所用者相同，惟將起始Tanneal由66 降至56°C。將經NcoI/SnaBI切割處理之PCR擴增物次選殖進入經NcoI/SnaBI切割處理之pMON35754中（其含有 IgG2b/G-CSF 基因）。pMON35768 (Flt3L (38/39) L21/IgG2b/G-CSF)於Flt3鑲嵌配對物之殘基15上具有一突變（Ser 至 Phe)。pMON35762 (FU3 樣板 pMON35739)、 pMON35763 (Flt3 樣板 35738)、pMON35758 (Flt3 樣板 35740) 、pMON35770 (以 pMON35743 作為 Flt3L 樣板）係如籲 pMON35764所述者建構。pMON35772 (pMON35760 中序列重排Flt3基因之S125至F125突變體）係使用pMON35715作為 Flt3樣板，並使用引子對65For/65SnaBI，藉由PCR而選殖。 PCR循環條件與前述用於自pMON35733、pMON35734、 pMON35735、及pMON35736擴增Flt3基因者相同。 PMON3 5 761係PMON3 5758中序列重排FU3L基因之Q133至 R133 突變體。pMON35773 (Flt3L 1-139 (38/39) L29/IgG2b/G-CSF)係如前述之pMON35774般進行選殖，惟 · 使用含有IgG2b/G-CSF基因之pMON26430 (經 NcoI/SnaBI/SAP處理）作為母載體。為建構39/40斷裂點當量物，在PCR擴增反應中使用 PMON3 5773作為樣板，並使用引子對Flt40/SnaBI C-term。擴增反應係如前述PMON35771者進行。將經NcoI/SnaBI切割處理之擴增產物次選殖進入PMON26430中（經 NcoI/SnaBI/SAP 處理），產生 pM〇N35779 (FU3L 1-139 (39/40) L29/IgG2b/G-CSF)。pM〇N35780係 pM〇N35779之變 O:\92\92747.DOC - 383 - 200413407 體，且其編碼序列重排Flt3鑲嵌配對物中之一單一胺基酸突變（L60 至 P60) 。 pM〇N32190 (Flt3L 1-139 (39/40) L21/GS/G-CSF)含有一不同之GlySer鑲嵌連接子，其取代 ?以0^3 2170中之1§〇21)連接子。將取自？：^(^32165 (於大腸桿菌表現載體 PMON5723 中之 Flt3L 1-139 (39/40) L21/IgG2b/IL-3受體促效劑 I)之 NcoI/SnaBI 片段 Flt3L 基因次選殖進入經NcoI/SnaBI切割處理之pMON31123中。其 BHK表現當量物 pMON35766係將整個 Flt3L/GlySer/G-CSF 鑲嵌插入子，以Ncol/Hindlll片段之形式，次選殖進入 pMON3934中而建構。 pMON39908與pMON35779類似，惟其以胺基酸序列 VETVFHRVSQDGLDLLTS 序歹丨J 編號 NO: 798取代 Flt3L胺基酸殘基133-160，該序列與一不同之Flt3L剪接變體 (Genebank登記號碼HSU29874)具有同源性。使用 pMON32190作為PCR樣板，並使用下列之引子對 Flt40/XbaRev 及 SnaBICterm/XbaFor。擴增條件如前述 PMON3 5 771者，惟將起始Tanneal由66降至64°C。將兩凝膠純化之 PCR 產物以 Ncol/Xbal (Flt40/XbaRev PCR 產物）或 Xbal/SnaBI (SnaBICterm/XbaFor PCR產物）進行切割處理，並次選殖進入PMON26430中（經NcoI/SnaBI/SAP處理）。 pM〇N32273 (Flt3L 1-139 (39/40) L21/IgG2b/G-CSF)係使用引子對 FltConNco/Grev，以 pMON35777 之 PCR，將 38/39 FU3L部分重新擴增為39/40。以NcoI/SnaBI切割處理純化之擴增物，並將其次選殖進入經NcoI/SnaBI切割處理之 O:\92\92747.DOC - 384 - 200413407 pMON32191中，命名為pMON32259 (用於大腸桿菌生產）。為進行BHK表現，將取自pM〇N32259之Ncol/Hindlll插入子次選殖進入 pMON3934 (NcoI/HindIII)中。實例103 建構另一系列之鑲嵌蛋白，其中Flt3L配對物含有一或二處 Cys 突變（表 XIA及XIB)。pMON35790 (Flt3L 1-139 (C4— S4，C85 一 S85)/GS/G，CSF (Se:rl7))係藉由 PCR，使用 PMON32191作為樣板，並使用引子對ClFor/C3Rev及 φ C3For/139Rev，以兩回合反應建構。pMON35791 (Flt3L 1-139 (C93—S93, C132—S132)/GS/G-CSF (Serl7))亦係藉由 PCR ，使用pMON32191作為樣板，並使用引子對C5For/C6Rev 及C5Rev/N-term而建構。擴增條件如前述pMON35771者，惟將起始Tanneal由66降至64°C。第二回合之PCR係使用取自第一回合反應之擴增物（各10微升）而進行，然後純化PCR 產物，以NcoI/SnaBI進行切割處理，並將其次選殖進入經 NcoI/SnaBI切割處理之pM〇N32191中。第二回合之PCR擴鲁增條件如下進行修飾：將起始Tanneal增加為68°C，且循環數目由6增加至1 5。不須其餘之擴增反應。此等建構， pMON35787 (C4-^S4^ C85-^ S85)^.pMON3578 8 (C93-^ S93 ^ Cl32 -> S132)係用於進行大腸桿菌表現者。其BHK表現當量物 ?]\4€^3 5 790及35 791係將正確之突變？1131^/〇1786；^〇-€8?鑲嵌插入子，以Ncol/Hindlll片段之形式，次選殖進入 pMON3934 中而建構。pMON35792 (Flt3L 1-132 (C132 — S132)/GlySer/G-CSF (Serl7))係藉由 PCR，使用 pMON32191 O:\92\92747.DOC - 385 - 200413407 作為樣板，並使用引子對FLDlRev/FltNTerm而建構。

pMON39905 (Flt3L 1-139 (C132 S132)/GlySer/G-CSF (Serl7))係藉由PCR，使用pMON32191作為樣板，並使用引子對 FLMlRev/FltNTerm 而建構。pMON39906 (Flt3L 1-139 (C127— S127/C132— S132)/GlySer/G-CSF (Serl7))含有一位於其序列重排Flt3L配對物之殘基127上之單一胺基酸取代，其為PMON3 9905之PCR擴增反應中所發生之PCR引入性錯誤之結果。pMON32276 (Flt3L 1-139 (39/40) L21 (C4—S4/C85 _ —S85)/GlySer/G_CSF (Serl7))係由兩回合之PCR而建構。製備三種起始擴增物：PCR1 (pMON32190樣板及引子對 G10/85N) ; PCR7 (pMON32190樣板及引子對4N/85S);及 PCR4 (pMON32198樣板及引子對4S/3605Rev)。在進行第二回合時，以結合之混合物形式重新擴增PCR1、4、及7，產生PCR A。純化PCR A，以NcoI/SnaBI切割處理之，並將其次選殖於pMON30277 (GlySer/G-CSF)中。下面三種建構係以類似之方法產生。pMON32277 (G-CSF (Serl7)/IgG2B φ /Flt3L 1-139 (39/40) L21 (C4—S4/C85->S85))之第一回合PCR 產生三種起始擴增物·· PCR1 (pMON32190樣板及引子對 G10/85N) ; PCR7 (pMON32190 樣板及引子對 4N/85S);及 PCR6 (pMON32169樣板及引子對4S/3605Rev)。在進行第二回合時，以結合之混合物形式重新擴增PCR1、6、及7，產生PCR B。純化PCR B，以Ncol/Hindlll切割處理之，並將其次選殖於 pMON30309 (G-CSF (Serl7)/IgG2B)中。 pMON32278 (Flt3L 1-139 (39/40) L21 (C93— S93/C132 — O:\92\92747.DOC -386 - 200413407 S132)/GlySer/G-CSF (Serl7))之第一回合PCR產生三種起始擴增物：PCR2 (pMON32190樣板及引子對G10L/93N); PCR8 (pMON32190 樣板及引子對 132N/93S);及 PCR3 (pMON32198樣板及引子對132S/3 605Rev)。在進行第二回合時，以結合之混合物形式重新擴增PCR2、3、及8，產生 PCR C。純化PCR C，以NcoI/SnaBI切割處理之，並將其次選殖於 pMON30277 (GlySer/G-CSF)中。pM〇N32279 (G-CSF (Serl7)/IgG2B/Flt3L 1-139 (39/40) L21 (C93-^ S93/C132-> S132)) · 之第一回合PCR產生三種起始擴增物：PCR2 (pMON32190 樣板及引子對G10L/93N) ; PCR8 (pMON32190樣板及引子對132N/93S); 及PCR5 (pMON32169樣板及引子對 13 2S/3 605Rev)。在進行第二回合時，以結合之混合物形式重新擴增PCR2、5、及8，產生PCR D。純化PCR D，以 Ncol/Hindlll切割處理之，並將其次選殖於經Ncol/Hindlll 切割處理之 pMON30309 (G-CSF (Serl7)/IgG2B)中。實例112 ❿ pMON39909 (Flt3L 1-139 (39/40) L21/GS/G-CSF (Serl7) (133/13 2))係兩種其中兩蛋白皆經序列重排之？113/〇-08?鑲嵌蛋白之一。將取自PMON32198之Ncol/Afllll片段（其含有 Flt3L 1-139 (19/40) L21/GlySer 基因）次選殖進入經

NcoI/SAP處理之pMON25187中（含有單一拷貝G-CSF (Seri7) (133/13 2)之大腸桿菌生產質體）。在確認DNA序列後，將該鑲嵌插入子以Ncol/Hindlll之形式次選殖進入 pM〇N3934 中，並命名為 pMON39909。pMON39910 (G-CSF O:\92\92747.DOC - 387 - 200413407 (Se;rl7) (133/132)/IgG2B/Flt3L 1-139 (39/40) L21)係藉由 PCR，使用pMON25 1 87作為樣板，並使用引子對 GPFoi*l/GPRev2而建構。擴增條件與pMON39908所用者相同。將經 NcoI/SnaBI 切割處理之 G-CSF(Serl7)(133/132)次選殖進入含有IgG2B/ Flt3L 1-139 (39/40) L21基因之 pMON32376 上之 NcoI/SnaBI 位點中。實例113 ρΜΟΝ40000係由pClneo (Promega)修飾而來之生產質體，含有 G-CSF (Serl7)/GlySer/Flt3L 1-139 (39/40) L21，用於在NS0細胞中進行表現（pMON32169係其BHK當量物）。 pMON40000含有CMV IE啟動子/增強子元件，毗鄰於CSF (Serl7)/GlySer/Flt3L 1-139 (39/40) L21 上游之 IL-3 引導序列，截短之胸苷激酶啟動子，SV40晚期聚-A信號序列，以及數段DNA酶1超敏區域（IgH 3 min LCR之部分）。實例114 多功能鑲嵌造血素受體促效劑之生物活性 O:\92\92747.DOC - 388 - 200413407 表14 活體外之多功能鑲嵌造血素受體促效劑生物分析純系 BAF3/FLT3L 增殖1 BAF3/FLT3L 增殖2 CFU-GM集落 3 pMON30247 + + + + pMON32169 + + + + + + pMON32175 + + + pMON32190 + + + PMON32191 + + + + + + pMON32333 + pMON32342 + + pMON32352 + + pMON32360 + + pMON35766 + pMON40000 + + + pMON400024 + + + + + 說明：

+ ：相較於控制組之較低效能（右移） ++：相當於控制組之效能（2倍之内） + + +: 相較於控制組之較高效能（左移） O:\92\92747.DOC - 389 - 1 相較於控制組：pMON30247 2 相較於控制組：pMON32352 3 相較於適當之共添加控制組 4 於純系PMON40000及pMON40002之混合物中之分析 200413407 實例115 生物活性測定表15 活體外之多功能鑲嵌造血素受體促效劑生物分析純系血細胞活體外擴展1 樹狀細胞活體外擴展2 倍數擴展嗜中性前體細胞巨核細胞前體倍數擴展功能 PMON32175 + + + pMON32191 + + + + + + + + pMON32360 + + + + + 11-3受體促效劑I， MFR促效劑I， MFR促效劑II + + + + + + 11-3受體促效劑I, MFR促效劑I， MFR促效劑II， PMON30247 + + + + + +++ 11-3受體促效劑I， MFR促效劑I， MFR促效劑II， pMON32360 + + + + + + + 11-3受體促效劑I， MFR促效劑I， MFR促效劑II， pMON32333 + + + + + + 11-3受體促效劑I， MFR促效劑I， MFR促效劑II， PMON32191 + + + +++ + + + 11-3受體促效劑I， MFR促效劑I， MFR促效劑II， PMON32175 + + + + + + + + MFR促效劑II， pMON32191 + + + + + PMON30247 + + + + + PMON32352 + +

O:\92\92747.DOC - 390 - 200413407 1說明： +: 相較於IL-3、IL-6、SCF、G-CSF (文獻控制組）之較低活性 ++:相當於IL-3、IL-6、SCF、G-CSF (文獻控制組）之活性 (20%之内） +++:相較於IL-3、IL-6、SCF、G-CSF (文獻控制組）之較高活性培養條件：X-Vivo 10培養基，37°C，5% C02，11天培養 2說明： +: 相較於GM_CSF、TNFa、SCF (文獻控制組）之較低活性 ++: 相當於GM-CSF、TNFa、SCF (文獻控制組）之活性（20% 之内） +++湘較於GM_CSF、TNFa、SCF (文獻控制組）之較高活性培養條件：添加100納克/毫升GM-CSF、100納克/毫升TNFa 、20納克/毫升SCF之IMDM-20培養基，於37°C/5% C02下， 18-22天 MFR促效劑 I = pMON31140 (WO 95/21 197) MFR 促效劑 II = pMON28571 (WO 97/12985) O:\92\92747.DOC -391 - 200413407 血細胞活體外擴展分析分離取自人類骨髓之CD34+富集祖細胞，並以5 X 104細胞 /毫升之濃度，於X-Vivo 10 + 1% HSA中，與受試細胞因子及控制祖進行培養，以評估細胞因子擴展效能。擴展細胞，並在約第5天時（根據細胞生長之情形），以5 X 104細胞/ 毫升之濃度，以新培養基及細胞因子重新進行平板培養。在第10天時，收集細胞並進行定性。自培養平板上收集細胞，並稀釋至1 X 1 06細胞/毫升之濃度。測定總細胞擴展量，並以甲基纖維素中（Stem Cell Technologies， ?^^化〇〇1111:11(：003 5 3 4)之前-及後擴展0?1；，定性該等細胞中之造血祖細胞。亦以流式細胞計數，定性經擴展細胞中之譜系專一性表型：CDllb (PE)/CD15 (FITC)，CD34 (FITC) ，CD41a (FITC)。樹狀細胞活體外擴展分析分離取自人類骨髓之CD34+富集祖細胞，並以2 X 105細胞/毫升之濃度，於IMDM/20% FCS中，與受試細胞因子及控制祖進行培養，以評估擴展效能。擴展細胞，並在約第5 天時（根據細胞生長之情形），以5 X 104細胞/毫升之濃度，以新培養基及細胞因子重新進行平板培養。在第1 8 - 2 2天時，收集細胞並進行定性。測定總細胞擴展量。以流式細胞計數，定性經擴展細胞中之譜系專一性表型：HLA-DR+ (PE)/CDla+ (FITC)，CD86+ (PE)/CDla+ (FITC)，CD19-(FITC)。樹狀細胞之倍數擴展係以總細胞擴展 X % HLA-DR+/CDla+測定。細胞之功能活性係使用單向混合淋 O:\92\92747.DOC -392 - 200413407 巴細胞反應而測定。其將經清洗，且經照射之經培養樹狀細胞，以層級劑量加入96孔微滴定盤上之同種異體反應外周血單核細胞。該等樹狀細胞作為抗原呈遞細胞之能力係以反應細胞製備物中受激發之增殖程度而測定，其以3H胸菩納入之情形進行測量。實例116 受體結合

受體結合分析化合物 Flt3-Fc G-CSFR IL-3R，， Kd (nM) IC5〇 (nM) IC5〇 (nM) PMON32342 26 ，，7 > 1000 pMON30247 36丨丨7 麵 6.6 ’，0.5 pMON32360 45 Μ 17 26 (2) pMON32352 56 ，，5 一 13 丨，4 pMON32191 37 Μ 14 0.33 ’丨 0.01 晒 11-3受體促效劑II - > 1000 1.3 ，丨 0.2 Ι1·3受體促效劑I - > 1000 3.7 ，’ 0.6 G-CSF - 0.69 0.08 > 100

數據係以取自至少三次試驗之三重測定值之平均值” SEM 表示，惟PMON32360為例外，其中僅完成（2)次試驗 O:\92\92747.DOC - 393 - 200413407 於受體結合分析中，評估含有Fit-3促效劑之鑲嵌分子之親和力。BIACORE分析係以直接固定Flt3-Fc進行，且由自其所計算出之Kd值測定連結及分離速率常數。使用競爭性結合分析以評估鑲嵌分子與轉染於BaF3細胞中之G-CSF受體間，或與表現於BHK細胞中之IL-3受體次單元間之交互作用。利用此等細胞之競爭分析使用一種促效劑專一性之放射性配位體，並使用劑量反應曲線之logit-對數分析，產生競爭鑲嵌物之IC50值。實例117 活體内生物活性表17 鼠活體内多功能鑲嵌造血素受體促效劑分析數據純系外周血胰臟 I-Ab+/CDllc+ I-Ab+/CD8+ I-Ab+/CDllc+ I-Ab+/CD8+ CFU-GM/胰 DC細胞/微升血液 DC細胞/胰（x 106) 倍數增加 pMON30247 ND ND 33.5 23.8 78 pMON32342 ND ND 8.0 4.5 2 PMON32360 ND ND 64.5 37.5 183 PMON32191 17,089 2,379 133.5 78.9 53 以 pMON3 0247、pM〇N3 2342或 pMON3 2360 (150微克/天），或小鼠血清白蛋白（MSA，200微克/天），對C57BL/6小鼠進行皮下注射10天。在第11天，以心臟穿刺進行終結放血。以全血取得白血球計數。以梯度離心（Histopaque)取得外周血白血球，並再以氯化銨裂解進一步除去紅血球。使用 O:\92\92747.DOC -394 - 200413407 、，双合妾光素或漢紅蛋白之直接性單株抗體（Pharmingen)染色細胞’以進行流式細胞計數。在染色之前，先使用FcBl〇ck (Pharmingen)阻斷非專一性之以受體結合。以FacScan流式細胞計數儀（Becton/Dickinson)分析細胞。以積分法測定陽性細胞之百分比，並根據WBC計數，計算表型計數。無菌切除經處理動物之騰臟，在Rp]y[I培養基中，以針使其分散。使用5 cc針筒柱塞之扁平端取得細胞懸浮液，再通過棉塞過漉以除去團塊。以氯化銨裂解除去紅血球，清洗細胞，鲁使其重新懸浮，並使用Coulter計數儀（Coulter Electr〇nics) 進行冲數。如上所述處理細胞，以進行流式細胞計數。根據具有陽性表型之細胞百分比，以及總胰臟WBC計數，以細胞數目/胰臟表示表型。將i.5x 1〇5胰臟細胞/丨毫升之密度，於甲基纖維素之三重試驗孔中，以不含紅血球生成素之鼠類細胞因子（Stem Cell Technologies)，對細胞進行平板培養而取得CFU培養物。將培養物置於37^下1〇天，並於倒置顯微鏡上進行計數。CFU之定義係具有>5〇細胞之細胞籲集落。測足CFU/胰臟之倍數增加（受試化合物之總cFU數目 /胰臟/MSA控制組之總CFU數目/胰臟）。外周血之 I-A /CD11及I-Ab+/CD8+之?^八控制組值分別為15及347細胞/微升。胰臟白血球之1^+/〇〇11〇+及1_^/€1)8+之1^八控制組值分別為2及1 X 1 〇6細胞/胰臟。咸仏沾習此項技術者不須進一步之說明，即可使用前面之敘述而完全利用本發明。因此，下列之較佳特定具體實例僅係用以說明，其不於任何方面限制本發明其餘之揭示。 O:\92\92747.DOC -395 - 200413407 有關分子生物學技術、蛋白質純化、及生物分析之詳細說明可見於 WO 94/1263 9、WO 94/1263 8、WO 9/21197、 WO 95/20977、WO 95/21254、及 WO 96/23888，其全部併入本文作為參考文獻。本文所引述之所有文獻、專利、或專利申請案亦如其全文述於本文中般，全部併入本文作為參考文獻。在閱讀本發明之揭示後，熟習此項技術者亦可在不偏離本發明之精神及範圍之情形下，顯見各種不同之其他實例。此等其他實例亦皆涵括於本發明申請專利範圍之範疇内0 【圖式簡單說明】圖丄以流程說明蛋白質之序列重排。天然蛋白之n_端⑺）及c-端（CM系經由-連接子連接，或直接連接。該蛋白於— 產生新N-端（新_N)及新C_端（新_c)之斷裂點打開，產生且有新線性胺基酸序列之蛋白。重排分子可重新再以線性:予之形式合成’並不經連結原抓端及c_端及於蛋白之步驟。 1 · 不創造新蛋白之方法1之流程，其中天然蛋白之原始N-端及C.端係以連接子連接，且其創造不同之蛋白質N 端及c-端。在所示之實财，序列重排產生、編碼一蛋白，兮恭厶Θ 士、，具 N-端，原始C:(a 原始蛋白胺基酸97所創造之新接（/ % a.a. 174)經由—連接子區域與胺基酸11連新=刪除且其具有於原始序列胺基酸96創造之

O:\92\92747.DOC -396 - 200413407 圖3顯示創造新蛋白之方法II之流程，其中天然蛋白之原始N-端及C-端係不經由連接子連接，且其創造不同之蛋白質N-端及C-端。在所示之實例中，序列重排產生一新基因，其編碼一蛋白，該蛋白具有於原始蛋白胺基酸97所創造之新N-端，原始C-端（a.a. 174)與原始N-端連接，且其具有於原始序列胺基酸96創造之新C-端。圖4顯示創造新蛋白之方法III之流程，其中天然蛋白之原始N-端及C-端係以連接子連接，且其創造不同之蛋白質N-端及C-端。在所示之實例中，序列重排產生一新基因，其編碼一蛋白，該蛋白具有於原始蛋白胺基酸97所創造之新 N-端，原始C-端（a.a. 174)經由一連接子區域與胺基酸1連接，且其具有於原始序列胺基酸96創造之新C-端。圖5顯示含有flt-3受體促效劑pMON323 32、pMON3 23 33 、PMON323 34及pMON3233 5之多功能受體促效劑，相較於重組天然flt-3 (Genzyme)，在MUTZ-2細胞增殖分析中之生物活性。MT=模擬轉染圖6顯示編碼人類成熟EPO之DNA序列（根據Lin et al.之序列（PNAS 82:75 80-75 84、1995))。圖7a及7b顯示編碼天然幹細胞因子之DNA序列（根據 Martin et al.之序列（Cell 63:203-21 1、1990))。圖8顯示編碼可溶性幹細胞因子之DNA序列（根據Langley et al.之序歹丨J (Archives of Biochemistry and Biophysica 311:55-61、1994))。

圖9a及9b顯示編碼flt3配位體209胺基酸成熟形式之DNA O:\92\92747.DOC - 397 - 200413407 序列（取自 Lyman et al· (Oncogene 11:1165-1172、1995))。圖10顯示編碼flt3配位體134胺基酸可溶形式之DNA序列 (取自 Lyman et al. (〇nc〇gene 1 1:1 165-1 172、1995))。

O:\92\92747.DOC 398 - 200413407 序列表 (1) 一般資料： (i) 申請人：美商吉迪希瑞爾公司 (ii) 發明名稱：多功能鑲嵌造血素受體促效劑 (iii) 序列數目：865 (iv) 通訊住址： (A) 收件人：美商吉迪希瑞爾公司 (B) 街：郵政信箱5110號 (C) 市：芝加哥 (D) 州：伊利諾 (E) 國家：美國 (F) 郵遞區號：60680 (v) 電腦可讀形式： (A) 媒體形式：磁片 (B) 電腦：IBM PC可相容者

(C) 可操作系統：DOS (D) 軟體：FastSEQ for Windows，#2.0版 (vi) 本申請案資料： (A) 申請案號： (B) 申請曰：1997年10月22曰 (C) 分類： (vii) 先前申請案資料： (A) 申請案號：60/029 629 (B) 申請曰：1996年10月25曰 (viii) 律師/代理人資料：

(A) 姓名·· Bennett Dennis A (B) 註冊號碼：34 547

O:\92\92747.DOC 200413407 (C)參考/檔案號碼：C-2"4 (ix)電子通訊資料： (A) 電話：3 14-737-6986 (B) 傳真：3 14-737-6972 (C)電報： (2)序列編號NO: 1資料： (i)序列特性： (A) 長度：465鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構 :線形 (xi)序列描述：序列編號NO: 1 GCTAACTGCT CTATAATGAT CGATGAAAn ATACATCACT TAAAGAGACC ACCTGCACCT 60 TTGCTGGACC CGAACAACCT CAATGACGAA GACGTCTCTA TCCTGATGGA CCGAAACCTT 120 CGACTTCCAA ACCTGGAGAG CTTCGTAAGG GCTGTCAAGA ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGC TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGT 439 (2)序列編號NO: 2資料： (i)序列特性： (A)長度：465驗基對 (B) 形式：核 (C) 股數：單酸 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 2 TCCCCAGCTC CACCTGCTTG TGACCTCCGA GTCCTCAGTA AACTGCTTCG TGACTCCCAT 60 GTCCTTCACA GCAGACTGAG CCAGTGCCCA GAGGTTCACC CTTTGCCTAC ACCTGTCCTG 120 CTGCCTGCTG TGGACITTAG CTTGGGAGAA TGGAAAACCC AGATGGAGGA GACCAAGGCA 180 CAGGACATTC TGGGAGCAGT GACCCTTCTG CTGGAGGGAG TGATGGCAGC ACGGGGACAA 240 CTGGGACCCA CTTGCCTCTC ATCCCTCCTG GGGCAGCTTT CTGGACAGGT CCGTCTCCTC 300 CTTGGGGCCC TGCAGAGCCT CCTTGGAACC CAGCTTCCTC CACAGGGCAG GACCACAGCT 360 CACAAGGATC CCAATGCCAT CTTCCTGAGC TTCCAACACC TGCTCCGAGG AAAGGTGCGT 420 O:\92\92747.DOC -2- 200413407 TTCCTGATGC TTGTAGGAGG GTCCACCCTC TGCGTCAGGG (2)序列編號NO: 3資料： (i)序列特性： (A) 長度：972鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 3

TCCCCAGCTC CACCTGCTTG TGACCTCCGA GTCCTCAGTA

GTCCTTCACA GCAGACTGAG CCAGTGCCCA GAGGTTCACC

CTGCCTGCTG TGGACTTTAG CTTGGGAGAA TGGAAAACCC

CAGGACATTC TGGGAGCAGT GACCCTTCTG CTGGAC3GGAG

CTGGGACCCA CTTGCCTCTC ATCCCTCCTG GGGCAGCTTT

CTTGGGGCCC TGCAGAGCCT CCTTGGAACC CAGCTTCCTC

CACAAGGATC CCAATGCCAT CTTCCTGAGC HCCAACACC

TTCCTGATGC TTGTAGGAGG GTCCACCCTC TGCGTCAGGG

TCTCCCGCTC CGCCTGCTTG TGACCTCCGA GTCCTCAGTA

GTCCTTCACA GCAGACTGAG CCAGTGCCCA GAGGTTCACC

CTGCCTGCTG TGGACTITAG CTTGGGAGAA TGGAAAACCC

CAGGACATTC TGGGAGCAGT GACCCTTCTG CTGGAGGGAG

CTGGGACCCA CTTGCCTCTC ATCCCTCCTG GGGCAGCTTT

CTTGGGGCCC TGCAGAGCCT CCTTGGAACC CAGGGCAGGA

AATGCCATCT TCCTGAGCTT CCAACACCTG CTCCGAGGAA GTAGGAGGGT CCACCCTCTG CGTCAGG (2)序列編號NO: 4資料： (i)序列特性： (A) 長度：936鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 4

TCCCCAGCTC CACCTGCTTG TGACCTCCGA GTCCTCAGTA

GTCCTTCACA GCAGACTGAG CCAGTGCCCA GAGGTTCACC

CTGCCTGCTG TGGACTITAG CTTGGGAGAA TGGAAAACCC

CAGGACATTC TGGGAGCAGT GACCCTTCTG CTGGAGC5GAG CTGGGACCCA CTTGCCTCTC ATCCCTCCTG GGGCAGCm

CTTGGGGCCC TGCAGAGCCT CCTTGGAACC CAGCTTCCTC AATTC 465 AACTGCTTCG TGACTCCCAT 60 CTTTGCCTAC ACCTGTCCTG 600 AGATGGAGGA GACCAAGGCA 660 TGATGGCAGC ACGGGGACAA 720 CTGGACAGGT CCGTCTCCTC 780 CACAGGGCAG GACCACAGCT 360 TGCTCCGAGG AAAGGTGCGT 420 MTTCGGCGG CAACATGGCG 480 AACTGCTTCG TGACTCCCAT 540 CTTTGCCTAC ACCTGTCCTG 600 AGATGGAGGA GACCAAGGCA 660 TGATGGCAGC ACGGGGACAA 720 CTGGACAGGT CCGTCTCCTC 780 CCACAGCTCA CAAGGATCCC 840 AGGTGCGTTT CCTGATGCTT 900 927

AACTGCTTCG TGACTCCCAT 60 CTTTGCCTAC ACCTGTCCTG 120 AGATGGAGGA GACCAAGGCA 180 TGATGGCAGC ACGGGGACAA 240 CTGGACAGGT CCGTCTCCTC 300 CACAGGGCAG GACCACAGCT 360 O:\92\92747.DOC -3- 200413407

CACAAGGATC CCAATGCCAT CTTCCTGAGC TTCCAACACC TGCTCCGAGG AAAGGTGCGT 420 TTCCTGATGC TTGTAGGAGG GTCCACCCTC TGCGTCAGGG AATTCGGCAA CATGGCGTCT 480 CCCGCTCCGC CTGCTTGTGA CCTCCGAGTC CTCAGTAAAC TGCTTCGTGA CTCCCATGTC 540 CTTCACAGCA GACTGAGCCA GTGCCCAGAG GTTCACCCTT TGCCTACACC TGTCCTGCTG 600 CCTGCTGTGG ACTITAGCTT GGGAGAATGG AAAACCCAGA TGGAGGAGAC CAAGGCACAG 660 GACATTCTGG GAGCAGTGAC CCTTCTGCTG GAGGGAGTGA TGGCAGCACG GGGACAACTG 720 GGACCCACTT GCCTCTCATC CCTCCTGGGG CAGCTTTCTG GACAGGTCCG TcrccTccrr 780 GGGGCCCTGC AGAGCCTCCT TGGAACCCAG CTTCCTCCAC AGGGCAGGAC CACAGCTCAC 840 AAGGATCCCA ATGCCATCTT CCTGAGCTTC CMCACCTGC TCCGAGGAAA GGTGCGTTTC 900 CTGATGCTTG TAGGAGGGTC CACCCTCTGC GTCAGG 936 (2)序列編號NO: 5資料： (i)序列特性： (A)長度：939鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 5 TCCCCAGCTC CACCTGCTTG TCACCTCCGA GTCCTCAGTA AACTGCTTCG TGACTCCCAT 60 GTCCTTCACA GCAGACTGAG CCAGTGCCCA GAGGTTCACC CTTTGCCTAC ACCTGTCCTG 600 CTGCCTGCTG TGGACTITAG CTTGGGAGAA TGGAAAACCC AGATGGAGGA GACCAAC3GCA 660 CAGGACATTC TGGCAGCAGT GACCCTTCTG CTGGAGGGAG TGATGGCAGC ACGGGGACAA 720 CTGGGACCCA CTTGCCTCTC ATCCCTCCTG GGGCAGCTTT CTGGACAGGT CCGTCTCCTC 780 CTTGGGGCCC TGCAGAGCCT CCTTGGAACC CAGCTTCCTC CACAGGGCAG GACCACAGCT 840 CACAAGGATC CCAATGCCAT CTTCCTGAGC TTCCAACACC TGCTCCGAGG AAAGGTGCGT 900 TTCCTGATGC TTGTAGGAGG GTCCACCCTC TGCGTCACG 939G

AATTCGGCGG CAACATGGCG 480 TCTCCCGCTC CGCCTGCTTG TGACCTCCGA GTCCTCAGTA AACTGCTTCG TGACTCCCAT 540 GTCCTTCACA GCAGACTGAG CCAGTGCCCA GAGGTTCACC CTTTGCCTAC ACCTGTCCTG 600 CTGCCTGCTG TGGACTITAG CTTGGGAGAA TGGAAAACCC AGATGGAGGA GACCAAGGCA 660 CAGGACATTC TGGGAGCAGT GACCCTTCTG CTGGAGGGAG TGATGGCAGC ACGGGGACAA 720 CTGGGACCCA CTTGCCTCTC ATCCCTCCTG GGGCAGCTTT CTGGACAGGT CCGTCTCCTC 780 CTTGGGGCCC TGCAGAGCCT CCTTGGAACC CAGCTTCCTC CACAGGGCAG GACCACAGCT 840 CACAAGGATC CCAATGCCAT CTTCCTGAGC TTCCAACACC TGCTCCGAGG AAAGGTGCGT 900 HCCTGATGC TTGTAGGAGG GTCCACCCTC TGCGTCAGG 939

(2)序列編號NO·. 6資料： (i)序列特性： (A) 長度：948鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 O:\92\92747.DOC -4- 200413407 (xi)序列描述：序列編號NO: 6 TCCCCAGCGC CGCCTGCTTG TGACCTCCGA GTCCTCAGTA AACTGCTTCG TGACTCCCAT 60 GTCCTTCACA GCAGACTGAG CCAGTGCCCA GAGGTTCACC CTTTGCCTAC ACCTGTCCTG 120 CTGCCTGCTG TGGACTTTAG CTTGGGAGAA TGGAAAACCC AGATGGAGGA GACCAAGGCA 180 CAGGACATTC TGGGAGCAGT GACCCTTCTG CTGGAGGGAG TGATGGCAGC ACGGGGACAA 240 CTGGGACCCA CTTGCCTCTC ATCCCTCCTG GGGCAGOTT CTGGACAGGT CCGTCTCCTC 300 CTTGGGGCCC TGCAGAGCCT CCTTGGAACC CAGCTTCCTC CACAGGGCAG GACCACAGCT 360 CACaXGGATC CCAATGCCAT CTTCCTGAGC TTCCAACACC TGCTCCGAGG AAAGGTGCGT 420 TTCCTGATGC TTGTAGGAGG GTCCACCCTC TGCGTCAGGG AATTCGGCGG CAACGGCGGC 480 AACATGGCGT CCCCAGCGCC GCCTGCTTGT GACCTCCGAG TCCTCAGTAA ACTGCTTCGT 540 GACTCCCATG TCCTTCACAG CAGACTGAGC CAGTGCCCAG AGGTTCACCC TTTGCCTACA 600 CCTGTCCTGC TGCCTGCTGT GGACTTTAGC TTGGGAGAAT GGAAAACCCA GATGGAGGAG 660 ACCAAGGCAC AGGACATTCT GGGAGCAGTG ACCCTTCTGC TGGAGGGAGT GATGGCAGCA 720 CGGGGACAAC TGGGACCCAC TTGCCTCTCA TCCCTCCTGG GGCAGCTTTC TGGACAGGTC 780 CGTCTCCTCC TTGGGGCCCT GCAGAGCCTC CTTGGAACCC AGCTTCCTCC ACAC3GGCAGG 840 ACCACAGCTC ACAAGGATCC CAATGCCATC TTCCTGAGCT TCCAACACCT GCTCCGAGGA 900 AAGGTGCGTT TCCTGATGCT TGTAGGAGGG TCCACCCTCT GCGTCAGG 948

(2)序列編號NO·. 7資料： (i)序列特性： (A) 長度：688鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 7 CATGGCTAAC TGCTCTATAA TGATCGATGA AAmTACAT CACTTAAAGA GACCACCTGC 60 ACCTTTGCTG GACCCGAACA ACCTCAATGA CGAAGACGTC TCTATCCTGA TGGACCGAAA 120 CCTTCGACTT CCAAACCTGG AGAGCTTCGT AAGGGCTGTC AAGAACTTAG AAAATGCATC 180 AGGTATTGAG GCA/OTCTTC GTAATCTCCA ACCATGTCTG CCCTCTGCCA CGGCCGCACC 240 CTCTCGACAT CCAATCATCA TCAAGGCAGG TGACTGGCAA GMTTCCGGG AAAAACTGAC 300 GTTCTATCTG GmCCCTTG AGCAAGCGCA GGAACAACAG GGTGGTGGCT CTAACTGCTC 360 TATAATGATC GATGAAATTA TACATCACTT AAAGAGACCA CCTGCACCTT TGCTGGACCC 420 GAACAACCTC AATGACGAAG ACGTCTCTAT CCTGATGGAC CGAAACCTTC GACTTCCAAA 480 CCTGGAGAGC TTCGTAAGGG CTGTCAAGAA CTTAGAAAAT GCATCAGGTA TTGAGGCAAT 540 TCTTCGTAAT CTCCAACCAT GTCTGCCCTC TGCCACGGCC GCACCCTCTC GACATCCAAT 600 CATCATCAAG GCAGGTGACT GGCAAGMTT CCGGGAAAAA CTGACGTTCT ATCTGGTTAC 660 CCTTGAGCAA GCGCACGAAC AACAGTAC 688

(2)序列編號NO: 8資料： (i)序列特性： (A)長度：712鹼基對 O:\92\92747.DOC ·5· 200413407 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 8 CATGGCTAAC TGCTCTATAA TGATCGATGA AATTATACAT CACTTAAAGA GACCACCTGC 60 ACCTTTGCTG GACCCGAACA ACCTCAATGA CGAAGACGTC TCTATCCTGA TGGACCGAAA 120 CCTTCGACTT CCAAACCTGG AGAGCTTCGT AAGGGCTGTC AAGAACTTAG AAAATGCATC 180 AGGTATTGAG GCAATTCTTC GTAATCTCCA ACCATGTCTG CCCTCTGCCA CGGCCGCACC 240 CTCTCGACAT CCAATCATCA TCAAGGCAGG TGACTGGCAA GAATTCCGGG AAAAACTGAC 300 GTTCTATCTG GTTACCCTTG AGCAAGCGCA GGAACAACAG GGTGGTGGCT CTGGCGGTGG 360 CAGCGGCGGC GGTTCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACITAAAGAG 420 ACCACCTGCA CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT CTATCCTGAT 480 GGACCGAAAC CTTCGACTTC CAAACCTGGA GAGCTTCGTA AGGGCTGTCA AGAACTTAGA 540 AAATGCATCA GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC 600 GGCCGCACCC TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA 660 AAAACTGACG TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT AC 712

(2)序列編號NO: 9資料： (i)序列特性： (A) 長度：975鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 9

ATGGCTCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT CTATCCTGAT GGACCGAAAC 60 CTTCGACTTC CAAACCTGGA GAGCTTCGTA AGGGCTGTCA AGAACTTAGA AAATGCATCA 120 GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GCCCGCACCC 180 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG 240 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGG GTGGTGGCTC TAACTGCTCT 300 ATAATGATCG ATGAAATTAT ACATCACTTA AAGAGACCAC CTGCACCTTT GTACGTAGAG 360 GGCGGTGGAG GCTCCCCGGG TGAACCGTCT GGTCCAATCT CTACTATCAA CCCGTCTCCT 420 CCGTCTAAAG AATCTCATAA ATCTCCAAAC ATGGCTACCC AGGGTGCCAT GCCGGCCTTC 480 GCCTCTGCTT TCCAGCGCCG GGCAGGAGGG GTCCTGGTTG CTAGCCATCT GCAGAGCTTC 540 CTGGAGGTGT CGTACCGCGT TCTACGCCAC CTTGCGCAGC CCTCTGGCGG CTCTGGCGGC 600 TCTCAGAGCT TCCTGCTCAA GTCTTTAGAG CAAGTGACAA AGATCCAGGG CGATGGCGCA 660 GCGCTCCAGG AGAAGCTGTG TGCCACCTAC AAGCTGTGCC ACCCCGAGGA GCTGGTGCTG 720 CTCGGACACT CTCTGGGCAT CCCCTGGGCT CCCCTGAGCT CCTGCCCCAG CCAGGCCCTG 780 CAGCTGGCAG GCTGCTTGAG CCAACTCCAT AGCGGCCHT TCCTCTACCA GGGGCTCCTG 840 CAGGCCCTGG AAGGGATATC CCCCGAGTTG GGTCCCACCT TGGACACACT GCAGCTGGAC 900 GTCGCCGACT TTGCCACCAC CATCTGGCAG CAGATGGAAG AACTGGGAAT GGCCCCTGCC 960 CTGCAGCCCT AATAA 975 O:\92\92747.DOC -6- 200413407 (2)序列編號NO: 10資料： (i)序列特性： (A) 長度：975鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO·· 10 ATGGCTAATG CATCAGGTAT TGAGGCAATT CTTCGTAATC TCCAACCATG TCTGCCCTCT 60 GCCACGGCCG CACCCTCTCG ACATCCAATC ATCATCAAGG CAGGTGACTG GCAAGAATTC 120 CGGGAAAAAC TGACGTTCTA TCTGGTTACC CTTGAGCAAG CGCAGGAACA ACAGGGTGGT 180 GGCTCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG ACCACCTGCA 240 CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT CTATCCTGAT GGACCGAAAC 300 CTTCGACTTC CAAACCTGGA GAGCITCGTA AGGGCTGTCA AGAACTTAGA ATACGTAGAG 360 GGCGGTGGAG GCTCCCCGGG TGAACCGTCT GGTCCAATCT CTACTATCAA CCCGTCTCCT 420 CCGTCTAAAG AATCTCATAA ATCTCCAAAC ATGGCTACCC AGGGTGCCAT GCCGGCCTTC 480 GCCTCTGCTT TCCAGCGCCG GGCAGGAGGG GTCCTGCTTG CTAGCCATCT GCAGAGCTTC 540 CTGGAGGTGT CGTACCGCGT TCTACGCCAC CTTGCGCAGC CCTCTGGCGG CTCTGGCGGC 600 TCTCAGAGCT TCCTGCTCAA GTCTTTAGAG CAAGTGAGAA AGATCCAGGG CGATGGCGCA 660 GCGCTCCAGG AGAAGCTGTG TGCCACCTAC AAGCTGTGCC ACCCCGAGGA GCTGGTGCTG CCAGGCCCTG 720 CTCGGACACT CTCTGCjGCAT CCCCTGGGCT CCCCTGAGCT CCTGCCCCAG 780 CAGCTGGCAG GCTGCTTGAG CCAACTCCAT AGCGGCCTTT TCCTCTACCA GGGGCTCCTG 840 CAGGCCCTGG AAGGGATATC CCCCGAGTTG GGTCCCACCT TGGACACACT GCAGCTGGAC 900 GTCGCCGACT TTGCCACCAC CATCTGGCAG CAGATGGAAG AACTGGGAAT GGCCCCTGCC 960 CTGCAGCCCT AATAA 975 (2)序列編號NO: 11資料： ⑴序列特性： _ (A) 長度：975鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 11 ATGGCTGCAC CCTCTCGACA TCCAATCATC ATCAAGGCAG GTGACTGGCA AGAATTCCGG 60 GAAAAACTGA CGTTCTATCT GGTTACCCTT GAGCAAGCGC AGGAACAACA GGGTGGTGGC 120 TCTAACTGCT CTATAATGAT CGATGAMTT ATACATCACT TAAAGAGACC ACCTGCACCT 180 nGCTGGACC CGAACAACCT CAATGACGAA GACGTCTCTA TCCTGATGGA CCGAAACCTT 240 CGACITCCAA ACCTGGAGAG CTTCGTAAGG GCTGTCAAGA ACTTAGAAAA TGCATCAGGT 300 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CTACGTAGAG 360 GGCGGTGGAG GCTCCCCGGG TGAACCGTCT GGTCCAATCT CTACTATCAA CCCGTCTCCT 420

O:\92\92747.DOC 200413407 AGGGTGCCAT GCCGGCCTTC 480 CTAGCCATCT GCAGAGCTTC 540 CCTCTGGCGG CTCTGGCGGC 600 AGATCCAGGG CGATGGCGCA 660 ACCCCGAGGA GCTGGTGCTG 720 CCTGCCCCAG CCAGGCCCTG 780 TCCTCTACCA GGGGCTCCTG 840 TGGACACACT GCAGCTGGAC 900 AACTGGGAAT GGCCCCTGCC 960 975 CCGTCTAAAG AATCTCATAA ATCTCCAAAC ATGGCTACCC GCCTCTGCTT TCCAGCGCCG GGCAGGAGGG GTCCTGGTTG CTGGAGGTGT CGTACCGCGT TCTACGCCAC CTTGCGCAGC TCTCAGAGCT TCCTGCTCAA GTCTTTAGAG CAAGTGAGAA GCGCTCCAGG AGAAGCTGTG TGCCACCTAC AAGCTGTGCC CTCGGACACT CTCTGGGCAT CCCCTGGGCT CCCCTGAGCT CAGCTGGCAG GCTGCTTGAG CCAACTCCAT AGCGGCCnT CAGGCCCTGG AAGGGATATC CCCCGAGTTG GGTCCCACCT GTCGCCGACT TTGCCACCAC CATCTGGCAG CAGATGGAAG CTGCAGCCCT AATAA (2)序列編號NO: 12資料： ⑴序列特性： (A)長度：975鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 12

ATGGCTGCAG GTGACTGGCA AGAATTCCGG GAAAAACTGA

GAGCAAGCGC AGGAACAACA GGGTGGTGGC TCTAACTGCT

ATACATCACT TAAAGAGACC ACCTGCACCT TTGCTGGACC

GACGTCTCTA TCCTGATGGA CCGAAACCTT CGACTTCCAA

GCTGTCAAGA ACTTAGAAAA TGCATCAGGT ATTGAGGCAA

TGTCTGCCCT CTGCCACGGC CGCACCCTCT CGACATCCAA

GGCGGTGGAG GCTCCCCGGG TGAACCGTCT GGTCCAATCT

CCGTCTAAAG AATCTCATAA ATCTCCAAAC ATGGCTACCC

GCCTCTGCTT TCCAGCGCCG GGCAGGAGGG GTCCTGGTTG

CTGGAGGTGT CGTACCGCGT TCTACGCCAC CITGCGCAGC

TCTCAGAGCT TCCTGCTCAA GTCTTTAGAG CAAGTGAGAA

GCGCTCCAGG AGAAGCTGTG TGCCACCTAC AAGCTGTGCC

CTCGGACACT CTCTGGGCAT CCCCTGGGCT CCCCTGAGCT

CAGCTGGCAG GCTGCTTGAG CCAACTCCAT AGCGGCCTTT

CAGC5CCCTGG AAGGGATATC CCCCGAGTTG GGTCCCACCT

GTCGCCGACT TTGCCACCAC CATCTGGCAG CAGATGGAAG

CTGCAGCCCT AATAA (2)序列編號NOM3資料： (i)序列特性： (A) 長度：999鹼基對 (B) 形式：核酸 (C) 股數：單

CGTTCTATCT GGTTACCCTT 60 CTATAATGAT CGATGAMTT 120 CGAACAACCT CAATGACGAA 180 ACCTGGAGAG CTTCGTAAGG 240 TTCTTCGTAA TCTCCAACCA 300 TCATCATCAA GTACGTAGAG 360 CTACTATCAA CCCGTCTCCT 420 AGGGTGCCAT GCCGGCCTTC 480 CTAGCCATCT GCAGAGCTTC 540 CCTCTGGCGG CTCTGGCGGC 600 AGATCCAGGG CGATGGCGCA 660 ACCCCGAGGA GCTGGTGCTG 720 CCTGCCCCAG CCAGGCCCTG 780 TCCTCTACCA GGGGCTCCTG B40 TGGACACACT GCAGCTGGAC 900 AACTGGGAAT GGCCCCTGCC 960 975

O:\92\92747.DOC -8- 200413407 (D)拓撲結構：線形 (xi)序列描述：序列編號NO: 13 ATGGCTCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT CTATCCTGAT GGACCGAAAC 60 CTTCGACTTC CAAACCTGGA GAGCTTCGTA AGGGCTGTCA AGAACTTAGA AAATGCATCA 120 GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC 180 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG 240 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGG GTGGTGGCTC TGGCGGTGGC 300 AGCGGCGGCG GTTCTMCTG CTCTATAATG ATCGATGAAA mTACATCA CTTAAAGAGA 360 CCACCTGCAC CTTTGTACGT AGAGGGCGGT GGAGGCTCCC CGGGTGAACC GTCTGGTCCA 420 ATCTCTACTA TCAACCCGTC TCCTCCGTCT AAAGAATCTC ATAAATCTCC AAACATGGCT 480 ACCCAGGGTG CCATGCCGGC CTTCGCCTCT GCTTTCCAGC GCCGGGCAGG AGGGGTCCTG 540 GTTGCTAGCC ATCTGCAGAG CTTCCTGGAG GTGTCGTACC GCGTTCTACG CCACCTTGCG 600 CAGCCCTCTG GCGGCTCTGG CGGCTCTCAG AGCTTCCTGC TCAAGTCTTT AGAGCAAGTG 660 AGAAAGATCC AGGGCGATGG CGCAGCGCTC CAGGAGAAGC TGTGTGCCAC CTACAAGCTG 720 TGCCACCCCG AGGAGCTGGT GCTGCTCGGA CACTCTCTGG GCATCCCCTG GGCTCCCCTG 780 AGCTCCTGCC CCAGCCAGGC CCTGCAGCTG GCAGGCTGCT TGAGCCAACT CCATAGCGGC 840 CTTTTCCTCT ACCAGGGGCT CCTGCAGGCC CTGGAAGGGA TATCCCCCGA GnGGGTCCC 900 ACCTTGGACA CACTGCAGCT GGACGTCGCC GACTITGCCA CCACCATCTG GCAGCAGATG 960 GAAGAACTGG GAATGGCCCC TGCCCTGCAG CCCTAATAA 999

(2)序列編號NO·. 14資料： (i)序列特性： (A) 長度：999鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形

(xi)序列描述：序列編號NO: 14 ATGGCTAATG CATCAGGTAT TGAGGCMTT CITCGTAATC TCCAACCATG TCTGCCCTCT 60 GCCACGGCCG CACCCTCTCG ACATCCAATC ATCATCAAGG CAGGTGACTG GCAAGAATTC 120 CGGGAAAAAC TGACGTTCTA TCTGGTTACC CTTGAGCAAG CGCAGGAACA ACAGGGTGGT 180 GGCTCTGGCG GTGGCAGCGG CGGCGGTTCT AACTGCTCTA TAATGATCGA TGAAAmTA 240 CATCACTTAA AGAGACCACC TGCACCTTTG CTGGACCCGA ACAACCTCAA TGACGAAGAC 300 GTCTCTATCC TGATGGACCG AAACCTTCGA CTTCCAAACC TGGAGAGCTT CGTAAGGGCT 360 GTCAAGAACT TAGAATACGT AGAGGGCGGT GGAGGCTCCC CGGGTGAACC GTCTGGTCCA 420 ATCTCTACTA TCAACCCGTC TCCTCCGTCT AAAGAATCTC ATAAATCTCC AAACATGGCT 480 ACCCAGGGTG CCATGCCGGC CTTCGCCTCT GCHTCCAGC GCCGGGCAGG AGGGGTCCTG 540 GTTGCTAGCC ATCTGCAGAG CTTCCTGGAG GTGTCGTACC GCGTTCTACG CCACCTTGCG 600 CAGCCCTCTG GCGGCTCTGG CGGCTCTCAG AGCTTCCTGC TCAAGTCnT AGAGCAAGTG 660 AGAAAGATCC AGGGCGATGG CGCAGCGCTC CAGGAGAAGC TGTGTGCCAC CTACAAGCTG 720 TGCCACCCCG AGGAGCTGGT GCTGCTCGGA CACTCTCTGG GCATCCCCTG GGCTCCCCTG 780 AGCTCCTGCC CCAGCCAGGC CCTGCAGCTG GCAGGCTGCT TGAGCCAACT CCATAGCGGC 840 cmTCCTCT ACCAGGGGCT CCTGCAGGCC CTGGAAGGGA TATCCCCCGA GTTGGGTCCC 900 ACCTTGGACA CACTGCAGCT GGACGTCGCC GACTITGCCA CCACCATCTG GCAGCAGATG 960 GAAGAACTGG GAATGGCCCC TGCCCTGCAG CCCTAATAA 999 O:\92\92747.DOC -9- 200413407 (2)序列編號NO: 15資料： (i)序列特性： (A) 長度：999鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 15 ATGGCTGCAC CCTCTCGACA TCCAATCATC ATCAAGGCAG GTGACTGGCA AGAATTCCGG 60 GAAAAACTGA CGTTCTATCT GGTTACCCTT GAGCAAGCGC AGGAACAACA GGGTGGTGGC 120 TCTGGCGGTG GCAGCGGCGG CGGTTCTMC TGCTCTATM TGATCGATGA MTTATACAT 180 CACTTAAAGA GACCACCTGC ACCTTTGCTG GACCCGAACA ACCTCAATGA CGAAGACGTC 240 TCTATCCTGA TGGACCGase CCTTCGACTT CCAAACCTGG AGAGCTTCGT AAGGGCTGTC 300 AAGAACTTAG AAAATGCATC AGGTATTGAG GCAATTCTTC GTAATCTCCA ACCATGTCTG 360 CCCTCTGCCA CGGCCTACGT AGAGGGCGGT GGAGGCTCCC CGGGTGAACC GTCTGGTCCA 420 ATCTCTACTA TCAACCCGTC TCCTCCGTCT AAAGAATCTC ATAAATCTCC AAACATGGCT 480 ACCCAGGGTG CCATGCCGGC CTTCGCCTCT GOTTCCAGC GCCGGGCAGG AGGGGTCCTG 540 GTTGCTAGCC ATCTGCAGAG CTTCCTGGAG GTGTCGTACC GCGTTCTACG CCACCTTGCG 600 CAGCCCTCTG GCGGCTCTGG CGGCTCTCAG AGCTTCCTGC TCAAGTCTTT AGAGCAAGTG 660 AGAAAGATCC AGGGCGATGG CGCAGCGCTC CAGGAGAAGC TGTGTGCCAC CTACAAGCTG 720 TGCCACCCCG AGGAGCTGGT GCTGCTCGGA CACTCTCTGG GCATCCCCTG GGCTCCCCTG 780 AGCTCCTGCC CCAGCCAGGC CCTGCAGCTG GCAGGCTGCT TGAGCCAACT CCATAGCGGC 840 CTTTTCCTCT ACCAGGGGCT CCTGCAGGCC CTGGAAGGGA TATCCCCCGA GTTGGGTCCC 900 ACCTTGGACA CACTGCAGCT GGACGTCGCC GACTTTGCCA CCACCATCTG GCAGCAGATG 960 GAAGAACTGG GAATGGCCCC TGCCCTGCAG CCCTAATAA 999

(2)序列編號NO·. 16資料： (i)序列特性： (A) 長度：999鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 16

ATGGCTGCAG GTGACTGGCA AGAATTCCGG GAGCAAGCGC AGGAACAACA GGGTGGTGGC TGCTCTATM TGATCGATGA MTTATACAT GACCCGAACA ACCTCAATGA CGAAGACGTC CCAAACCTGG AGAGCTTCGT AAGGGCTGTC GCAATTCTTC GTAATCTCCA ACCATGTCTG GAAAAACTGA CGTTCTATCT GGTTACCCTT 60 TCTGGCGGTG GCAGCGGCGG CGGTTCTMC 120 CACTTAAAGA GACCACCTGC ACCTTTGCTG 180 TCTATCCTGA TGGACCGAAA CCTTCGACTT 240 AAGAACTTAG AAAATOCATC AGGTATTGAG 300 CCCTCTGCCA CGGCCGCACC CTCTCGACAT 360 O:\92\92747.DOC -10- 200413407 CCAATCATCA TCAAGTACGT AGAGGGCGGT GGAGGCTCCC CGGGTGAACC GTCTGGTCCA 420 ATCTCTACTA TCAACCCGTC TCCTCCGTCT AAAGAATCTC ATAAATCTCC AAACATGGCT 480 ACCCAGGGTG CCATGCCGGC CTTCGCCTCT GCTTTCCAGC GCCGGGCAGG AGGGGTCCTG 540 GTTGCTAGCC ATCTGCAGAG CTTCCTGGAG GTGTCGTACC GCGTTCTACG CCACCTTGCG 600 CAGCCCTCTG GCGGCTCTGG CGGCTCTCAG AGCTTCCTGC TCAAGTCTTT AGAGCAAGTG 660 AGAAAGATCC AGGGCGATGG CGCAGCGCTC CAGGAGAAGC TGTGTGCCAC CTACAAGCTG 720 TGCCACCCCG AGGAGCTGGT GCTGCTCGGA CACTCTCTGG GCATCCCCTG GGCTCCCCTG 780 AGCTCCTGCC CCAGCCAGGC CCTGCAGCTG GCAGGCTGCT TGAGCCAACT CCATAGCGGC 840 CTTTTCCTCT ACCAGGGGCT CCTGCAGGCC CTGGAAGGGA TATCCCCCGA GTTGGGTCCC 900 ACCTTGGACA CACTGCAGCT GGACGTCGCC GACTTTGCCA CCACCATCTG GCAGCAGATG 960

GAAGAACTGG GAATGGCCCC TGCCCTGCAG CCCTAATAA 999 (2)序列編號NO: 17資料： (i)序列特性：

(A) 長度：918鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NOM7 ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG ACCACCTGCA 60 CCnTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT CTATCCTGAT GGACCGAAAC 120 CTTCGACTTC CAAACCTGGA GAGCTTCGTA AGGGCTGTCA AGAACTTAGA AAATGCATCA 180 GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC 240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG 300 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGC3G CGGTGGAGGC 360 TCCCCGC3GTG GTGGTTCTGG CGGCGGCTCC AACATGGCTT ACAAGCTGTG CCACCCCGAG 420 GAGCTGGTGC TGCTCGGACA CTCTCTGGGC ATCCCCTGGG CTCCCCTGAG CTCCTGCCCC 480 AGCCAGGCCC TGCAGCTGGC AGGCTGCITG AGCCAACTCC ATAGCGGCCT TTTCCTCTAC 540 CAGGGGCTCC TGCAGGCCCT GGAAGGGATA TCCCCCGAGT TGGGTCCCAC CTTGGACACA 600 CTGCAGCTGG ACGTCGCCGA CTTTGCCACC ACCATCTGGC AGCAGATGGA AGAACTGGGA 660 ATGGCCCCTG CCCTGCAGCC CACCCAGGGT GCCATGCCGG CCTTCGCCTC TGCTTTCCAG 720 CGCCGGGCAG GAGGGGTCCT GGTTGCTAGC CATCTGCAGA GCTTCCTGGA GGTGTCGTAC 780 CGCGTTCTAC GCCACCTTGC GCAGCCCTCT GGCGGCTCTG GCGGCTCTCA GAGCITCCTC 840 CTCAAGTCTT TAGAGCAAGT GAGAAAGATC CAGGGCGATG GCGCAGCGCT CCAGGAGAAG 900 CTGTGTGCCA CCTAATAA 918 (2)序列編號NO·· 18資料：

⑴序列特性： (A)長度：963鹼基對 (B) 形式：核酸 (C) 股數：單 O:\92\92747.DOC -11- 200413407 (D)拓撲結構：線形 (xi)序列描述：序列編號NO: 18 ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG ACCACCTGCA 60 CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT CTATCCTGAT GGACCGAAAC 120 CTTCGACTTC CAAACCTGGA GAGCTTCGTA AGGGCTGTCA AGAACTTAGA AAATGCATCA 180 GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC 240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG 300 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG CGGTGGAGGC 360 TCCCCGGGTG AACCGTCTGG TCCAATCTCT ACTATCAACC CGTCTCCTCC GTCTAAAGAA 420 TCTCATaseT CTCCAAACAT GGCTTACAAG CTGTGCCACC CCGAGGAGCT GGTGCTGCTC 480 GGACACTCTC TGGGCATCCC CTGGGCTCCC CTGAGCTCCT GCCCCAGCCA GGCCCTGCAG 540 CTGGCAGGCT GCTTGAGCCA ACTCCATAGC GGCCTTTTCC TCTACCAGGG GCTCCTGCAG 600 GCCCTGGAAG GGATATCCCC CGAGTTGGGT CCCACCTTGG ACACACTGCA GCTGGACGTC 660 GCCGACTTTG CCACCACCAT CTGGCAGCAG ATGGAAGAAC TGGGAATGGC CCCTGCCCTG 720 CAGCCCACCC AGGGTGCCAT GCCGGCCTTC GCCTCTGCTT TCCAGCGCCG GGCAGGAGGG 780 GTCCTGGTTG CTAGCCATCT GCAGAGCTTC CTGGAGGTGT CGTACCGCGT TCTACGCCAC 840 CTTGCGCAGC CCTCTGGCGG CTCTGGCGGC TCTCAGAGCT TCCTGCTCAA GTCTTTAGAG 900 CAAGTGAGAA AGATCCAGGG CGATGGCGCA GCGCTCCAGG AGAAGCTGTG TGCCACCTAA 960 TAA 963

(2)序列編號NO: 19資料： (i)序列特性： (A) 長度：918鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形

(xi)序列描述：序列編號NO: 19 ATGGCTAACT GCTCTATAAT GATCGATGAA AmTACATC ACTTAAAGAG ACCACCTGCA 60 CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT CTATCCTGAT GGACCGAAAC 120 CTTCGACTTC CAAACCTGGA GAGCTTCGTA AGGGCTGTCA AGAACTTAGA AAATGCATCA 180 GGTATTGAGG CAAnCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC 240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG 300 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG CGGTGGAGGC 360 TCCCCGGGTG GTGGTTCTGG CGGCGGCTCC AACATGGCTC CCGAGTTGGG TCCCACCTTG 420 GACACACTGC AGCTGGACGT CGCCGACTTT GCCACCACCA TCTGGCAGCA GATGGAAGAA 480 CTGGGAATGG CCCCTGCCCT GCAGCCCACC CAGGGTGCCA TGCCGGCCTT CGCCTCTGCT 540 TTCCAGCGCC GGGCAGGAGG GGTCCTGGTT GCTAGCCATC TGCAGAGCTT CCTGGAGGTG 600 TCGTACCGCG TTCTACGCCA CCTTGCGCAG CCCTCTGGCG GCTCTGGCGG CTCTCAGAGC 660 TTCCTGCTCA AGTCTTTAGA CCAAGTGAGA AAGATCCAGG GCGATGGCGC AGCGCTCCAG 720 GAGAAGCTGT GTGCCACCTA CAAGCTGTGC CACCCCGAGG AGCTGGTGCT GCTCGGACAC 780 TCTCTGGGCA TCCCCTGGGC TCCCCTGAGC TCCTGCCCCA GCCAGGCCCT GCAGCTGGCA 840 GGCTGCTTGA GCCAACTCCA TAGCGGCCTT TTCCTCTACC AGGGGCTCCT GCAGGCCCTG 900 GAAGGGATAT CCTAATAA 918 O:\92\92747.DOC -12- 200413407 (2)序列編號NO: 20資料： (i)序列特性： (A) 長度：963鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO·. 20 ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG ACCACCTGCA 60 CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT CTATCCTGAT GGACCGAAAC 120 CTTCGACTTC CAAACCTGGA GAGCTTCGTA AGGGCTGTCA AGAACTTAGA AAATGCATCA 180 GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC 240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AAITCCGGGA AAAACTGACG 300 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG CGGTGGAGGC 360 TCCCCGGGTG AACCGTCTGG TCCAATCTCT ACTATCAACC CGTCTCCTCC GTCTAAAGAA 420 TCTCATAAAT CTCCAAACAT GGCTCCCGAG HGGGTCCCA CCTTGGACAC ACTGCAGCTG 480 GACGTCGCCG ACTTTGCCAC CACCATCTGG CAGCAGATGG AAGAACTGGG AATGGCCCCT 540 GCCCTGCAGC CCACCCAGGG TGCCATGCCG GCCTTCGCCT CTGCTTTCCA GCGCCGGGCA 600 GGAGGGGTCC TGGTTGCTAG CCATCTGCAG AGCTTCCTGG AGGTGTCGTA CCGCGTTCTA 660 CGCCACCITG CGCAGCCCTC TGGCGGCTCT GGCGGCTCTC AGAGCTTCCT GCTCAAGTCT 720 mGAGCAAG TGAGAAAGAT CCAGGGCGAT GGCGCAGCGC TCCAGGAGAA GCTGTGTGCC 780 ACCTACAAGC TGTGCCACCC CGAGGAGCTG GTGCTGCTCG GACACTCTCT GGGCATCCCC 840 TGGGCTCCCC TGAGCTCCTG CCCCAGCCAG GCCCTGCAGC TGGCAGGCTG CTTGAGCCAA 900 CTCCATAGCG GCCTTTTCCT CTACCAGGGG CTCCTGCAGG CCCTGGAAGG GATATCCTAA 960 TAA 963 (2)序列編號NO: 21資料： (i)序列特性： (A)長度：918鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 21 ATGGCTAACT GCTCTATAAT GATCGATGAA AmTACATC ACTTAAAGAG ACCACCTGCA 60 CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT CTATCCTGAT GGACCGAAAC 120 CTTCGACTTC CAAACCTGGA GAGCTTCGTA AGGGCTGTCA AGAACTTAGA AAATGCATCA 180 GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC 240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG 300 TTCTATCTGG mCCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG CGGTGGAGGC 360 TCCCCGGGTG GTGGTTCTGG CGGCGGCTCC AACATGGCTA TGGCCCCTGC CCTGCAGCCC 420 ACCCAGGGTG CCATGCCGGC CTTCGCCTCT GCTTTCCAGC GCCGGGCAGG AGGGGTCCTG 480

O:\92\92747.DOC -13- 200413407

GTTGCTAGCC ATCTGCAGAG CAGCCCTCTG GCGGCTCTGG AGAAAGATCC AGGGCGATGG TGCCACCCCC AGGAGCTGGT AGCTCCTGCC CCAGCCAGGC CnTTCCTCT ACCAGGGGCT ACCTTGGACA CACTGCAGCT GAAGAACTGG GATAATAA

CTTCCTGGAG GTGTCGTACC CGGCTCTCAG AGCTTCCTGC CGCAGCGCTC CAGGAGAAGC GCTGCTCGGA CACTCTCTGG CCTGCAGCTG GCAGGCTGCT CCTGCAGGCC CTGGAAGGGA GGACGTCGCC GACTTTGCCA GCGTTCTACG CCACCTTGCG 540 TCAAGTCTTT AGAGCAAGTG 6⑻ TGTGTGCCAC CTACAAGCTG 660 GCATCCCCTG GGCTCCCCTG 720 TGAGCCAACT CCATAGCGGC 780 TATCCCCCGA GTTGGGTCCC 840 CCACCATCTG GCAGCAGATG 900 918 (2)序列編號NO: 22資料： (i)序列特性： (A) 長度：963鹼基對 (B) 形式：核酸

(C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 22 ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG . ACCACCTGCA 60 CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT CTATCCTGAT GGACCGAAAC 120 CTTCGACTTC CAAACCTGGA GAGCTTCGTA AGGGCTGTCA AGAACTTAGA AAATGCATCA 180 GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC 240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG 300 TTCTATCTGG mCCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG CGGTGGAGGC 360 TCCCCGGGTG AACCGTCTGG TCCAATCTCT ACTATCAACC CGTCTCCTCC GTCTAAAGAA 420 TCTCATAAAT CTCCAAACAT GGCTATGGCC CCTGCCCTGC AGCCCACCCA GGGTGCCATG 480 CCGGCCTTCG CCTCTGCTTT CCAGCGCCGG GCAGGAGGGG TCCTGGTTGC TAGCCATCTG 540 CAGAGCTTCC TGGAGGTGTC GTACCGCGTT CTACGCCACC HGCGCAGCC CTCTGGCGGC 600 TCTGGCGGCT CTCAGAGCTT CCTGCTCAAG TCTTTAGAGC AAGTGAGAAA GATCCAGGGC 660 GATGGCGCAG CGCTCCAGGA GAAGCTGTGT GCCACCTACA AGCTGTGCCA CCCCGAGGAG 720 CTGGTGCTGC TCGGACACTC TCTGGGCATC CCCTGGGCTC CCCTGAGCTC CTGCCCCAGC 780 CAGGCCCTGC AGCTGGCAGG CTGCTTGAGC CAACTCCATA GCGGCCTTTT CCTCTACCAG 840 GGGCTCCTGC AGGCCCTGGA AGGGATATCC CCCGAGITGG GTCCCACCTT GGACACACTG 900 CAGCTGGACG TCGCCGACTT TGCCACCACC ATCTGGCAGC AGATGGAAGA ACTGGGATAA 960 TAA 963

(2)序列編號NO·. 23資料： (i)序列特性： (A) 長度：918鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 23 O:\92\92747.DOC -14 200413407 ATGGCTAACT GCTCTATAAT GATCGATGAA ATOTACATC ACTTAAAGAG ACCACCTGCA 60 CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT CTATCCTGAT GGACCGAAAC 120 CTTCGACTTC CAAACCTGGA GAGCTTCGTA AGGGCTGTCA AGAACTTAGA AAATGCATCA 180 GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC 240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG 300 TTCTATCTGG mCCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG CGGTGGAGGC 360 TCCCCGGGTG GTGGTTCTGG CGGCGGCTCC AACATGGCTA CCCAGGGTGC CATGCCGGCC 420 TTCGCCTCTG CTTTCCAGCG CCGGGCAGGA GGGGTCCTGG TTGCTAGCCA TCTGCAGAGC 480 nCCTGGAGG TGTCGTACCG CGTTCTACGC CACCTTGCGC AGCCCTCTGG CGGCTCTGGC 540 GGCTCTCAGA GCTTCCTGCT CAAGTCTTTA GAGCAAGTGA GAAAGATCCA GGGCGATGGC 600 GCAGCGCTCC AGGAGAAGCT GTGTGCCACC TACAAGCTGT GCCACCCCGA GGAGCTGGTG 660 CTGCTCGGAC ACTCTCTGGG CATCCCCTGG GCTCCCCTGA GCTCCTGCCC CAGCCAGGCC 720 CTGCAGCTGG CAGGCTGCTT GAGCCAACTC CATAGCGGCC TTTTCCrCTA CCAGGGGCTC 780 CTGCAGGCCC TGGAAGGGAT ATCCCCCGAG TTGGGTCCCA CCTTGGACAC ACTGCAGCTG 840 GACGTCGCCG ACTTTGCCAC CACCATCTGG CAGCAGATGG AAGAACTGGG AATGGCCCCT 900

GCCCTGCAGC CCTAATAA 918

(2)序列編號NO: 24資料： (i)序列特性： (A) 長度：963鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構·線形 (xi)序列描述：序列編號NO: 24 ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG ACCACCTGCA 60 CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT CTATCCTGAT GGACCGAAAC 120 CTTCGACTTC CAAACCTGGA GAGCTTCGTA AGGGCTGTCA AGAACTTAGA AAATGCATCA 180 GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC 240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG 300 TTCTATCTGG mCCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG CGGTGGAGGC 360 TCCCCGGGTG AACCGTCTGG TCCAATCTCT ACTATCAACC CGTCTCCTCC GTCTAAAGAA 420 TCTCATAAAT CTCCAAACAT GGCTACCCAG GGTGCCATGC CGGCCTTCGC CTCTGCTTTC 480 CAGCGCCGGG CAGGAGCGGT CCTGGTTGCT AGCCATCTGC AGAGCTTCCT GGAGGTGTCG 540 TACCGCGTTC TACGCCACCT TGCGCAGCCC TCTGGCGGCT CTGGCGGCTC TCAGAGCTTC 600 CTGCTCAAGT CTTTAGAGCA AGTGAGAAAG ATCCAGGGCG ATGGCGCAGC GCTCCAGGAG 660 AAGCTGTGTG CCACCTACAA GCTGTGCCAC CCCGAGGAGC TGGTGCTGCT CGGACACTCT 720 CTGGGCATCC CCTGGGCTCC CCTGAGCTCC TGCCCCAGCC AGGCCCTGCA GCTGGCAGGC 780 TGCTTGAGCC AACTCCATAG CGGCCmTC CTCTACCAGG GGCTCCTGCA GGCCCTGGAA 840 GGGATATCCC CCGAGnGGG TCCCACCTTG GACACACTGC AGCTGGACGT CGCCGACITT 900 GCCACCACCA TCTGGCAGCA GATGGAAGAA CTGGGAATGG CCCCTGCCCT GCAGCCCTAA 960 TAA 963

(2)序列編號NO: 25資料： (i)序列特性： O:\92\92747.DOC -15- 200413407 (A) 長度：918鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 25 ATGGCTMCT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG ACCACCTGCA 60 CCTITGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT CTATCCTGAT GGACCGAAAC 120 CTTCGACTTC CAAACCTGGA GAGCTTCGTA AGGGCTGTCA AGAACTTAGA AAATGCATCA 180 GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC 240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG 300 TTCTATCTGG TTACCCITGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG CGGTGGAGGC 360 TCCCCGGGTG GTGGTTCTGG CGGCGGCTCC AACATGGCTT CTGCTTTCCA GCGCCGGGCA 420 GGAGGGGTCC TGGTTGCTAG CCATCTGCAG AGCTTCCTGG AGGTGTCGTA CCGCGTTCTA 480 CGCCACCTTG CGCAGCCCTC TGGCGGCTCT GGCGGCTCTC AGAGCTTCCT GCTCAAGTCT 540 TTAGAGCAAG TGAGAAAGAT CCAGGGCGAT GGCGCAGCGC TCCAGGAGAA GCTGTGTGCC 600 ACCTACAAGC TGTGCCACCC CGAGGAGCTG GTGCTGCTCG GACACTCTCT GGGCATCCCC 660 TGGGCTCCCC TGAGCTCCTG CCCCAGCCAG GCCCTGCAGC TGGCAGGCTG CTTGAGCCAA 720 CTCCATAGCG Gccrnrccr CTACCAGGGG CTCCTGCAGG CCCTGGAAGG GATATCCCCC 780 GAGTTGGGTC CCACCTTGGA CACACTGCAG CTGGACGTCG CCGACTTTGC CACCACCATC 840 TGGCAGCAGA TGGAAGAACT GGGAATGGCC CCTCCCCTGC AGCCCACCCA GGGTGCCATG 900

CCGGCCITCG CCTAATAA 918

(2)序列編號NO: 26資料： (i)序列特性： (A) 長度：963鹼基對

(B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO·. 26 ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG ACCACCTGCA 60 CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT CTATCCTGAT GGACCGAAAC 120 CTTCGACTTC CAAACCTGGA GAGCTTCGTA AGGGCTGTCA AGAACTTAGA AAATGCATCA 180 GGTATTGAGG CA/OTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC 240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG 300 TTCTATCTGG TTACCCITGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG CGGTGGAGGC 360 TCCCCGGGTG AACCGTCTGG TCCAATCTCT ACTATCAACC CGTCTCCTCC GTCTAAAGAA 420 TCTCATAAAT CTCCAAACAT GGCTTCTGCT TTCCAGCGCC GGGCAGGAGG GGTCCTGGTT 480 GCTAGCCATC TGCAGAGCTT CCTGGAGGTG TCGTACCGCG TTCTACGCCA CCTTGCGCAG 540 CCCTCTGGCG GCTCTGGCGG CTCTCAGAGC TTCCTGCTCA AGTOTTAGA GCAAGTGAGA 600 AAGATCCAGG GCGATGGCGC AGCGCTCCAG CAGAAGCTGT GTGCCACCTA CAAGCTGTGC 660 CACCCCGAGG AGCTGGTGCT GCTCGGACAC TCTCTGGGCA TCCCCTGGGC TCCCCTGAGC 720 TCCTGCCCCA GCCAGGCCCT GCAGCTGGCA GGCTGCTTGA GCCAACTCCA TAGCGGCCTT 780 O:\92\92747.DOC -16- 200413407 TTCCTCTACC AGGGGCTCCT GCAGGCCCTG GAAGGGATAT CCCCCGAGTT GGGTCCCACC 840 TTGGACACAC TGCAGCTGGA CGTCGCCGAC TTTGCCACCA CCATCTGGCA GCAGATGGAA 900 GAACTGGGAA TGGCCCCTGC CCTGCAGCCC ACCCAGGGTG CCATGCCGGC CTTCGCCTAA 960 TAA 963 (2)序列編號NO·· 27資料： ⑴序列特性： (A) 長度：927鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 27 ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG ACCACCTGCA 60 CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT CTATCCTGAT GGACCGAAAC 120 CTTCGACITC CAAACCTGGA GAGCTTCGTA AGGGCTGTCA AGAACTTAGA AAATCCATCA 180 GGTATTGAGG CAAnCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC 240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG 300 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG CGGTGGAGGC 360 TCCCCGGGTG GTGGTTCTGG CGGCGGCTCC AACATGGCTT ACAAGCTGTG CCACCCCGAG 420 GAGCTGGTGC TGCTCGGACA CTCTCTGGGC ATCCCCTGGG CTCCCCTGAG CTCCTGCCCC 480 AGCCAGGCCC TGCAGCTGGC AGGCTGCITG AGCCAACTCC ATAGCGGCCT TTTCCTCTAC 540 CAGGGGCTCC TGCAGGCCCT GGAAGGGATA TCCCCCGAGT TGGGTCCCAC CTTGGACACA 600 CTGCAGCTGG ACGTCGCCGA CTTTGCCACC ACCATCTGGC AGCAGATGGA AGAACTGGGA 660 ATGGCCCCTG CCCTGCAGCC CACCCAGGGT GCCATGCCGG CCTTCGCCTC TGCTTTCCAG 720 CGCCGGGCAG GAGGGGTCCT GGTTGCTAGC CATCTGCAGA GCTTCCTGGA GGTGTCGTAC 780 CGCGTTCTAC GCCACCTTGC GCAGCCCACA cCmGGGCC CTGCCAGCTC CCTGCCCCAG 840 AGCTTCCTGC TCAAGTCTTT AGAGCAAGTG AGAAAGATCC AGGCJCGATGG CGCAGCGCTC 900 CAGGAGAAGC TGTGTGCCAC CTAATAA 927 (2)序列編號NO: 28資料： (i)序列特性： (A) 長度：972鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 28 ATGGCTAACT GCTCTATAAT GATCGATGAA AmTACATC ACTTAAAGAG ACCACCTGCA 60 CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT CTATCCTGAT GGACCGAAAC 120 CITCGACTTC CAAACCTGGA GAGCTTCGTA AGGGCTGTCA AGAACTTAGA AAATGCATCA 180 GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC 240 O:\92\92747.DOC -17- 200413407 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG 300 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG CGGTGGAGGC 360 TCCCCGGGTG AACCCTCTGG TCCAATCTCT ACTATCAACC CGTCTCCTCC GTCTAAAGAA 420 TCTCATAAAT CTCCAAACAT GGCTTACAAG CTGTGCCACC CCGAGGAGCT GGTGCTGCTC 480 GGACACTCTC TGGGCATCCC CTGGGCTCCC CTGAGCTCCT GCCCCAGCCA GGCCCTGCAG 540 CTGGCAGGCT GCTTGAGCCA ACTCCATAGC GGCCTTTTCC TCTACCAGGG GCTCCTGCAG 600 GCCCTGGAAG GGATATCCCC CGAGHGGGT CCCACCTTGG ACACACTGCA GCTGGACGTC 660 GCCGACTTTG CCACCACCAT CTGGCAGCAG ATGGAAGAAC TGGGAATGGC CCCTGCCCTG 720 CAGCCCACCC AGGGTGCCAT GCCGGCCITC GCCTCTGCTT TCCAGCGCCG GGCAGGAGGG 780 GTCCTGGTTG CTAGCCATCT GCAGAGCITC CTGGAGGTGT CGTACCGCGT TCTACGCCAC 840 CTTGCGCAGC cCACACCATT GGGCCCTGCC AGCTCCCTGC CCCAGAGCTT CCTGCTCAAG 900 TCTTTAGAGC AAGTGAGAAA GATCCAGGGC GATGGCGCAG CGCTCCAGGA GAAGCTGTGT 960 GCCACCTAAT AA 972 (2)序列編號NO: 29資料：

(i)序列特性： (A) 長度：927鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 29 ATGCCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG ACCACCTGCA 60 CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT CTATCCTGAT GGACCGAAAC 120 CTTCGACTTC CAAACCTGGA GAGCTTCGTA AGGGCTGTCA AGAACTTAGA AAATGCATCA 180 GGTATTGAGG CkmCHCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC 240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG 300 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG CGGTGGAGGC 360 TCCCCGGGTG GTGGTTCTGG CGGCGGCTCC AACATGGCTC CCGAGTTGGG TCCCACCTTG 420 GACACACTGC AGCTGGACGT CGCCGACTTT GCCACCACCA TCTGGCAGCA GATGGAAGAA 480 CTGGGAATGG CCCCTGCCCT GCAGCCCACC CAGGGTGCCA TGCCGGCCTT CCCCTCTGCT 540 TTCCAGCCCC GGGCACGAGG GGTCCTGCnT GCTAGCCATC TGCAGAGCTT CCTGGAGGTG 600 TCGTACCGCG TTCTACGCCA CCTTGCGCAG CCCACACCAT TGGGCCCTGC CAGCTCCCTG 660 CCCCAGAGCT TCCTGCTCAA GTCITTAGAG CAAGTGAGAA AGATCCAGGG CGATGGCGCA 720 GCGCTCCAGG AGAAGCTGTG TGCCACCTAC AAGCTGTGCC ACCCCGAGGA GCTGGTGCTG 780 CTCGGACACT CTCTGGGCAT CCCCTGGGCT CCCCTGAGCT CCTGCCCCAG CCAGGCCCTG 840 CAGCTGGCAG GCTGCTTGAG CCAACTCCAT AGCGGCCTTT TCCTCTACCA GGGGCTCCTG 900 CAGGCCCTGG AAGGGATATC CTAATAA 927

(2)序列編號NO: 30資料： (i)序列特性： (A) 長度：972鹼基對 (B) 形式：核酸 O:\92\92747_DOC -18- 200413407 (c)股數：單 (D)拓撲結構：線形 (xi)序列描述：序列編號NO: 30 ATGGCTAACT GCTCTATAAT GATCGATGAn ATTATACATC ACTTAAAGAG ACCACCTGCA 60 CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT CTATCCTGAT GGACCGAAAC 120 CTTCGACTTC CAAACCTGGA GAGCTTCGTA ACGGCTGTCA AGAACTTAGA AAATGCATCA 180 GGTATTGAGG CMTTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC 240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG 300 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG CGGTGGAGGC 360 TCCCCGGGTG AACCGTCTCG TCCAATCTCT ACTATCAACC CGTCTCCTCC GTCTAAAGAA 420 TCTCATAAAT CTCCAAACAT GGCTCCCGAG TTGGCTCCCA CCTTGGACAC ACTGCAGCTG 480 GACGTCGCCG ACTTTGCCAC CACCATCTGG CAGCAGATGG AAGAACTGGG AATGGCCCCT 540 GCCCTGCAGC CCACCCAGGG TGCCATGCCG GCCTTCGCCT CTGCTTTCCA GCGCCGGGCA 600 GGAGGGGTCC TGGTrGCTAG CCATCTGCAG AGCTTCCTGG AGGTGTCGTA CCGCGTTCTA 660 CGCCACCTTG CGCAGCCCAC ACCATTGGGC CCTGCCAGCT CCCTGCCCCA GAGCTTCCTG 720 CTCAAGTCTT TAGAGCAAGT GAGAAAGATC CAGGGCGATG GCGCAGCGCT CCAGGAGAAG 780 CTGTGTGCCA CCTACAAGCT GTGCCACCCC GAGGAGCTGG TGCTGCTCGG ACACTCTCTG 840 GGCATCCCCT GGGCTCCCCT GAGCTCCTGC CCCAGCCAGG CCCTGCAGCT GGCAGGCTGC 900 TTGAGCCAAC TCCATAGCGG CCTTTTCCTC TACCAGGGGC TCCTGCAGGC CCTGGAAGGG 960 ATATCCTAAT AA 972

(2)序列編號NO: 31資料： (i)序列特性： (A) 長度：927鹼基對 (B) 形式：核酸 (C) 股數：單

(D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 31 ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG ACCACCTGCA 60 CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT CTATCCTGAT GGACCGAAAC 120 CTTCGACTTC CAAACCTGGA GAGCTTCGTA AGGGCTGTCA AGAACTTAGA AAATGCATCA 180 GCHWITGAGG CMTTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC 240 TCTCGACATC CAATCATCAT CAAGGCAGCT GACTGGCAAG AATTCCGGGA AAAACTGACG 300 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG CGGTGGAGGC 360 TCCCCGGGTG GTGGITCTGG CGGCGGCTCC AACATGGCTA TGGCCCCTGC CCTGCAGCCC 420 ACCCAGGGTG CCATGCCGGC CTTCGCCTCT GCTTTCCAGC GCCGGGCAGG AGGGGTCCTG 480 GTTGCTAGCC ATCTGCAGAG CTTCCTGGAG GTGTCGTACC GCGTTCTACG CCACCTTGCG 540 CAGCCCACAC CATTGGGCCC TGCCAGCTCC CTGCCCCAGA GCTTCCTGCT CAAGTCTTTA 600 GAGCAAGTGA GAAAGATCCA GGGCGATGGC GCAGCGCTCC AGGAGAAGCT GTGTGCCACC 660 TACAAGCTGT GCCACCCCGA GGAGCTGGTG CTGCTCGGAC ACTCTCTGGG CATCCCCTGG 720 GCTCCCCTGA GCTCCTGCCC CAGCCAGGCC CTGCAGCTGG CAGGCTGCTT GAGCCAACTC 780 CATAGCGGCC TTTTCCTCTA CCAGGGGCTC CTGCAGGCCC TGGAAGGGAT ATCCCCCGAG 940 TTGGGTCCCA CCTTGGACAC ACTGCAGCTG GACGTCGCCG ACITTGCCAC CACCATCTGG 900 O:\92\92747.DOC -19- 200413407 CAGCAGATGG AAGAACTGGG ATAATAA 927 (2)序列編號NO: 32資料： (i)序列特性· (A) 長度：972鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO.· 32 ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG ACCACCTGCA 60 CCnTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT CTATCCTGAT GGACCGAAAC 120 CTTCGACTTC CAAACCTGGA GAGCTTCGTA AGGGCTGTCA AGAACTTAGA AAATGCATCA 180 GGTATTGAGG CAATTCITCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC 240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AAmCGGGA AAAACTGACG 300 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG CGGTGGAGGC 360 TCCCCGGGTG AACCGTCTGG TCCAATCTCT ACTATCAACC CGTCTCCTCC GTCTAAAGAA 420 TCTCATAAAT CTCCAAACAT GGCTATGGCC CCTGCCCTGC AGCCCACCCA GGGTGCCATG 480 CCGGCCTTCG CCTCTGCnT CCAGCGCCGG GCAGGAGGGG TCCTGGTTGC TAGCCATCTG 540 CAGAGCTTCC TGGAGGTGTC GTACCGCGTT CTACGCCACC TTGCGCAGCC CACACCATTG 600 GGCCCTGCCA GCTCCCTGCC CCAGAGCTTC CTGCTCAAGT CTTTAGAGCA AGTGAGAAAG 660 ATCCAGGGCG ATGGCGCAGC GCTCCAGGAG AAGCTGTGTG CCACCTACAA GCTGTGCCAC 720 CCCGAGGAGC TGGTGCTGCT CGGACACTCT CTGGGCATCC CCTGGGCTCC CCTGAGCTCC 780 TGCCCCAGCC AGGCCCTGCA GCTGGCAGGC TGCITGAGCC AACTCCATAG CGGCCTTTTC 840 CTCTACCAGG GGCTCCTGCA GGCCCTGGAA GGGATATCCC CCGAGTTGGG TCCCACCTTG 900 GACACACTGC AGCTGGACGT CGCCGACTTT GCCACCACCA TCTGGCAGCA GATGGAAGAA 960 CTGGGATAAT AA 972 (2)序列編號NO: 33資料： (i)序列特性· (A) 長度·· 927鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 33 ATGGCTAACT GCTCTATAAT GATCGATGAA AmTACATC ACTTAAAGAG ACCACCTGCA 60 CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT CTATCCTGAT GGACCGAAAC 120 CTTCGACTTC CAAACCTGGA GAGCTTCGTA AGGGCTGTCA AGAACTTAGA AAATGCATCA 180 GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC 240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG 300 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG CGGTGGAGGC 360 O:\92\92747.DOC -20- 200413407 TCCCCGGGTG GTGGTTCTGG CGGCGGCTCC AACATGGCTA CCCAGGGTGC CATGCCGGCC 420 TTCGCCTCTG CTTTCCAGCG CCGGGCAGGA GGGGTCCTGG TTGCTAGCCA TCTGCAGAGC 480 TTCCTGGAGG TGTCGTACCG CGTTCTACGC CACCTTGCGC AGCCCACACC ATTGGGCCCT 540 GCCAGCTCCC TGCCCCAGAG CTTCCTGCTC AAGTCTTTAG AGCAAGTGAG AAAGATCCAG 600 GGCGATGGCG CAGCGCTCCA GGAGAAGCTG TGTGCCACCT ACAAGCTGTG CCACCCCGAG 660 GAGCTGGTGC TGCTCGGACA CTCTCTGGGC ATCCCCTGGG CTCCCCTGAG CTCCTGCCCC 720 AGCCAGGCCC TGCAGCTGGC AGGCTGCTTG AGCCAACTCC ATAGCGGCCT TTTCCTCTAC 780 CAGGGGCTCC TGCAGGCCCT GGAAGGGATA TCCCCCGAGT TGGGTCCCAC CTTGGACACA 840 CTGCAGCTGG ACGTCGCCGA CTTTGCCACC ACCATCTGGC AGCAGATGGA AGAACTGGGA 900 ATGGCCCCTG CCCTGCAGCC CTAATAA 927 (2)序列編號NO: 34資料： (i)序列特性： (A) 長度：972鹼基對 (B) 形式：核酸籲 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 34 ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACITAAAGAG ACCACCTGCA 60 CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT CTATCCTGAT GGACCGAAAC 120 CTTCGACITC CAAACCTGGA GAGCTTCGTA AGGGCTGTCA AGAACTTAGA AAATGCATCA 180 GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC 240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG 300 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG CGGTGGAGGC 360 TCCCCGGGTG AACCGTCTGG TCCAATCTCT ACTATCAACC CGTCTCCTCC GTCTAAAGAA 420 TCTCATAAAT CTCCAAACAT GGCTACCCAG GGTGCCATGC CGGCCITCGC CTCTGCTTTC 480 CAGCGCCGGG CAGGAGGGGT CCTGGTTGCT AGCCATCTGC AGAGCITCCT GGAGGTGTCG 540 TACCGCGTTC TACGCCACCT TGCGCAGCCC ACACCATTGG GCCCTGCCAG CTCCCTGCCC 600 CAGAGCTTCC TGCTCAAGTC TTTAGAGCAA GTGAGAAAGA TCCAGGGCGA TGGCGCAGCG 660 CTCCAGGAGA AGCTGTGTGC CACCTACAAG CTGTGCCACC CCGAGGAGCT GGTGCTGCTC 720 GGACACTCTC TCGGCATCCC CTGGCCTCCC CTGAGCTCCT GCCCCAGCCA GGCCCTGCAG 780 CTGGCAGGCT GCTTGAGCCA ACTCCATAGC GGCCTTTTCC TCTACCAGGG GCTCCTGCAG 840 GCCCTGGAAG GGATATCCCC CGAGITGGGT CCCACCTTGG ACACACTGCA GCTGGACGTC 900 GCCGACTTTG CCACCACCAT CTGGCAGCAG ATGGAAGAAC TGGGAATGGC CCCTGCCCTG 960 CAGCCCTAAT AA 972

(2)序列編號NO: 35資料： (i)序列特性： (A) 長度：927鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 O:\92\92747.DOC -21- 200413407 (xi)序列描述：序列編號NO: 35 ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG ACCACCTGCA 60 CCTTTGCTGG ACCCGAACAA CCTCAATGAC GaXGACGTCT CTATCCTGAT GGACCGAAAC 120 CTTCGACTTC CAAACCTGGA GAGCTTCGTA AGGGCTGTCA AGAACTTACA AAATGCATCA 180 GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC 240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AAnCCGGGA AAAACTGACG 300 TTCTATCTGG mCCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG CGGTGGAGGC 360 TCCCCGGGTG GTGGTTCTGG CGGCGGCTCC AACATGCCTT CTGCmCCA GCGCCGGGCA 420 GGAGGGGTCC TGGTTGCTAG CCATCTGCAG AGCITCCTGG AGGTGTCGTA CCGCGTTCTA 480 CGCCACCTTG CGCAGCCCAC ACCATTGGGC CCTGCCAGCT CCCTGCCCCA GAGCTTCCTG 540 CTCAAGTCTT TAGAGCAAGT GAGAAAGATC CAGGGCGATG GCGCAGCGCT CCAGGAGAAG 600 CTGTGTGCCA CCTACAAGCT GTGCCACCCC GAGGAGCTGG TGCTGCTCGG ACACTCTCTG 660 GGCATCCCCT GGGCTCCCCT GAGCTCCTGC CCCAGCCAGG CCCTGCAGCT GGCAGGCTGC 720 TTGAGCCAAC TCCATAGCGG CCTTTTCCTC TACCAGGGGC TCCTGCAGGC CCTGGAAGGG 780 ATATCCCCCG AGTTGGGTCC CACCTTGGAC ACACTGCAGC TGGACGTCGC CGACTTTGCC 840 ACCACCATCT GGCAGCAGAT GGAAGAACTG GGAATGGCCC CTGCCCTGCA GCCCACCCAG 900 GGTGCCATGC CGGCCTTCGC CTAATAA 927 (2)序列編號NO: 36資料： (i)序列特性： (A)長度：972鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 36 ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG ACCACCTGCA 60 CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT CTATCCTGAT GGACCGAAAC 120 CTTCGACTTC CAAACCTGGA GAGCTTCGTA AGGGCTGTCA AGAACTTAGA AAATGCATCA 180 GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC 240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG A/OTCCGGGA AAAACTGACG 300 TTCTATCTGG ™CCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG CGGTGGAGGC 360 TCCCCGGGTG AACCGTCTGG TCCAATCTCT ACTATCAACC CGTCTCCTCC GTCTAAAGAA 420 TCTCATAAAT CTCCAAACAT GGCTTCTGCT TOCAGCGCC GGGCAGGAGG GGTCCTGGTT 480 GCTAGCCATC TGCAGAGCTT CCTGGAGGTG TCGTACCGCG HCTACGCCA CCTTGCGCAG 540 CCCACACCAT TGGC5CCCTGC CAGCTCCCTG CCCCAGAGCT TCCTGCTCAA GTCHTAGAG 600 CAAGTGAGAA AGATCCAGGG CGATGGCGCA GCGCTCCAGG AGAAGCTGTG TGCCACCTAC 660 AAGCTGTGCC ACCCCGAGGA GCTGGTGCTG CTCGGACACT CTCTGGGCAT CCCCTGCjGCT 720 CCCCTGAGCT CCTGCCCCAG CCAGGCCCTG CAGCTGGCAG GCTGCTTGAG CCAACTCCAT 780 AGCGGCCTTT TCCTCTACCA GGGGCTCCTG CAGGCCCTGG AAGGGATATC CCCCGAGTTG 840 GGTCCCACCT TGGACACACT GCAGCTGGAC GTCGCCGACT TTGCCACCAC CATCTGGCAG 900 CAGATGGAAG AACTGGGAAT GGCCCCTGCC CTGCAGCCCA CCCAGGGTGC CATGCCGGCC 960 TTCGCCTAAT AA 972

(2)序列編號NO: 37資料： O:\92\92747.DOC -22- 200413407 ⑴序列特性： (A) 長度：963鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 37 ATGGCTAACT GCTCTAACAT GATCGATGAA ATCATCACCC ACCTGAAGCA GCCACCGCTG 60 CCGCTGCTGG ACTTCAACAA CCTCAATGGT GAAGACCAAG ATATCCTAAT GGACAATAAC 120 CTTCGTCGTC CAAACCTCGA GGCATTCAAC CGTGCTGTCA AGTCTCTGCA GAATGCATCA 180 GCAATTGAGA GCATTCTTAA AAATCTCCTG CCATGTCTGC CGCTAGCCAC GGCCGCACCC 240 ACGCGACATC CAATCCATAT CAAGGACGGT GACTGGAATG AATTCCGTCG TAAACTGACC 300 TTCTATCTGA AAACCTTGGA GAACGCGCAG GCTCAACAGT ACGTAGAGGG CGGTGGAGGC 360 TCCCCGGGTG AACCGTCTGG TCCAATCTCT ACTATCAACC CGTCTCCTCC GTCTAAAGAA 420 TCTCATAAAT CTCCAAACAT GGCTACCCAG GGTGCCATGC CGGCCTTCGC CTCTGCTTTC 480 CAGCGCCGGG CAGGAGGGGT CCTGCTTGCT AGCCATCTGC AGAGCTTCCT GGAGGTGTCG 540 TACCGCGTTC TACGCCACCT TGCGCAGCCC TCTGGCGGCT CTGGCGGCTC TCAGAGCTTC 600 CTGCTCAAGT CTTTAGAGCA AGTGAGAAAG ATCCAGGGCG ATGGCGCAGC GCTCCAGGAG 660 AAGCTGTGTG CCACCTACAA GCTGTGCCAC CCCGAGGAGC TGGTGCTGCT CGGACACTCT 720 CTGGGCATCC CCTGGGCTCC CCTGAGCTCC TGCCCCAGCC AGGCCCTGCA GCTGGCAGGC 780 TGCTTGAGCC AACTCCATAG CGGCCTTTTC CTCTACCAGG GGCTCCTGCA GGCCCTGGAA 840 GGGATATCCC CCGAGTTGGG TCCCACCTTG GACACACTGC AGCTGGACGT CGCCGACTTT 900 GCCACCACCA TCTGGCAGCA GATGGAAGAA CTGGGAATGG CCCCTGCCCT GCAGCCCTAA 960 TAA 963 (2)序列編號NO·· 38資料： (i)序列特性： (A)長度：972鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 38 ATGGCTAACT GCTCTAACAT GATCGATGAA ATCATCACCC ACCTGAAGCA GCCACCGCTG 60 CCGCTGCTGG ACTTCAACAA CCTCAATGGT GAAGACCAAG ATATCCTGAT GGAAAATAAC 120 CTTCGTCGTC CAAACCTCGA GGCATTCAAC CGTGCTGTCA AGTCTCTGCA GAATGCATCA 180 GCAATTGAGA GCATTCTTAA AAATCTCCTG CCATGTCTGC CCCTGGCCAC GGCCGCACCC 240 ACGCGACATC CAATCATCAT CCGTGACGGT GACTGGAATG AAHCCGTCG TAAACTGACC 300 TTCTATCTGA AAACCTTGGA GAACGCGCAG GCTCAACAGT ACGTAGAGGG CGGTGGAGGC 360 TCCCCGGGTG AACCGTCTGG TCCAATCTCT ACTATCAACC CGTCTCCTCC GTCTAAAGAA 420 TCTCATAAAT CTCCAAACAT GGCTACCCAG GGTGCCATGC CGGCCTTCGC CTCTGCTTTC 480 CAGCGCCGGG CAGGAGGGGT CCTGCTTGCT AGCCATCTGC AGAGCTTCCT GGAGGTGTCG 540 TACCGCGTTC TACGCCACCT TGCGCAGCCC ACACmTGG GCCCTGCCAG CTCCCTGCCC 600 O:\92\92747.DOC -23- 200413407 CAGAGCTTCC TGCTCAAGTC TTTAGAGCAA GTGAGAAAGA TCCAGGGCGA TGGCGCAGCG 660 CTCCAGGAGA AGCTGTGTGC CACCTACAAG CTGTGCCACC CCGAGGAGCT GGTGCTGCTC 720 GGACACTCTC TGGGCATCCC CTGGGCTCCC CTGAGCTCCT GCCCCAGCCA GGCCCTGCAG 780 CTGGCAGGCT GCTTGAGCCA ACTCCATAGC GGCCTTTTCC TCTACCAGGG GCTCCTGCAG 840 GCCCTGGAAG GGATATCCCC CGAGTTGGGT CCCACCTTGG ACACACTGCA GCTGGACGTC 900 GCCGACTTTG CCACCACCAT CTGGCAGCAG ATGGAAGAAC TGGGAATGGC CCCTGCCCTG 960 CAGCCCTAAT AA 972 (2)序列編號NO: 39資料： (i)序列特性： (A) 長度：963鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 39 ATGGCTAACT GCTCTAACAT GATCGATGAA ATCATCACCC ACCTGAAGCA CCCACCGCTG 60 CCGCTGCTGG ACTTCAACAA CCTCAATGGT GAAGACCAAG ATATCCTGAT GGAAAATAAC 120 CTTCGTCGTC CAAACCTCGA GGCATTCAAC CGTGCTGTCA AGTCTCTGCA GAATGCATCA 180 GCAATTGAGA GCATTCTTAA AAATCTCCTG CCATGTCTGC CCCTGGCCAC GGCCGCACCC 240 ACGCGACATC CAATCATCAT CCGTGACGGT GACTCGAATG AATTCCGTCG TAAACTGACC 300 TTCTATCTGA AAACCTTGGA GAACGCGCAG GCTCAACAGT ACGTAGAGGG CGGTGGAGGC 360 TCCCCGGGTG AACCGTCTGG TCCAATCTCT ACTATCAACC CGTCTCCTCC GTCTAAAGAA 420 TCTCATAAAT CTCCAAACAT GGCTACCCAG GGTGCCATGC CGGCCTTCGC CTCTGCnTC 480 CAGCGCCGGG CAGGAGGGGT CCTGGTTGCT AGCCATCTGC AGAGCTTCCT GGAGGTGTCG 540 TACCGCGTTC TACGCCACCT TGCGCAGCCC TCTGGCGGCT CTGGCCGCTC TCAGAGCTTC 600 CTGCTCAAGT CTTTAGAGCA AGTGAGAAAG ATCCAGGGCG ATGGCGCAGC GCTCCAGGAG 660 AAGCTGTGTG CCACCTACAA GCTGTGCCAC CCCGAGGAGC TGGTGCTGCT CGGACACTCT 720 CTGGGCATCC CCTGGGCTCC CCTGAGCTCC TGCCCCAGCC AGGCCCTGCA GCTGGCAGGC 780 TGCTTGAGCC AACTCCATAG CGGCCTTTTC CTCTACCAGG GGCTCCTGCA GGCCCTGGAA 840 GGGATATCCC CCGAGTTGGG TCCCACCTTG GACACACTGC AGCTGGACGT CGCCGACTTT 900 GCCACCACCA TCTGGCAGCA GATGGAAGAA CTGGGAATGG CCCCTGCCCT GCAGCCCTAA 960 TAA 963 (2)序列編號NO: 40資料： (i)序列特性： (A) 長度：970鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 40 O:\92\92747.DOC -24- 200413407 ATGGCTAACT GCTCTAACAT GATCGATGAA ATCATCACCC ACCTGAAGCA GCCACCGCTG 60 CCGCTGCTGG ACTTCAACAA CCTCAATGGT GAAGACCAAG ATATCCTAAT GGACAATAAC 120 CTTCGTCGTC CAAACCTCGA GGCATTCAAC CGTGCTGTCA AGTCTCTGCA GAATGCATCA 180 GCAATTGAGA GCATTCTTAA AAATCTCCTG CCATGTCTGC CGCTAGCCAC GGCCGCACCC 240 GCGACATCCA ATCCATATCA AGGACGGTGA CTGGAATGAA TTCCGTCGTA AACTGACCTT 300 CTATCTGAAA ACCTTGGAGA ACGCGCAGGC TCAACAGTAC GTAGAGGGCG GTGGAGGCTC 360 CCCGGGTGAA CCGTCTGGTC CAATCTCTAC TATCAACCCG TCTCCTCCGT CTAAAGAATC 420 TCATAAATCT CCAAACATGG CTACCCAGGG TGCCATGCCG GCCTTCGCCT CTGCTTTCCA 480 GCGCCGGGCA GGAGGGGTCC TGGTTGCTAG CCATCTGCAG AGCTTCCTGG AGGTGTCGTA 540 CCGCGTTCTA CGCCACCTTG CGCAGCCCAC ACCATTGGGC CCTGCCAGCT CCCTGCCCCA 600 GAGCTTCCTG CTCAAGTCTT TAGAGCAAGT GAGAAAGATC CAGGGCGATG GCGCAGCGCT 660 CCAGGAGAAG CTGTGTGCCA CCTACAAGCT GTGCCACCCC GAGGAGCTGG TGCTGCTCGG 720 ACACTCTCTG CGCATCCCCT GGGCTCCCCT GAGCTCCTGC CCCAGCCAGG CCCTGCAGCT 780 GGCAGGCTGC HGAGCCMC TCCATAGCGG CCTTTTCCTC TACCAGGGGC TCCTGCAGGC 840 CCTGGAAGGG ATATCCCCCG AGTTGGGTCC CACCTTGGAC ACACTGCAGC TGGACGTCGC 900 CGACTTTGCC ACCACCATCT GGCAGCAGAT GGAAGAACTG GGAATGGCCC CTGCCCTGCA 960 GCCCTAATAA 970 (2)序列編號NO: 41資料： (i)序列特性： (A)長度：918鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 41 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTGCACCT 60 TTGCTGGACC CGAACAACCT CAATGACGAA GACGTCTCTA TCCTGATGGA CCGAAACCTT 120 CGACTTCCAA ACCTGGAGAG CTTCGTAAGG GCTGTCAAGA ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA ΉCΠCG^k^ TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGA GGITCACCCT 7TGCCTACAC CTGTCCTGCT CCCTGCTGTG 480 GACTTTAGCT TGGGAGAATG GAAAACCCAG ATGGAGGAGA CCAAGGCACA GGACATTCTG 540 GGAGCAGTGA CCCTTCTGCT GGAGGGAGTG ATGGCAGCAC GGGGACAACT GGGACCCACT 600 TGCCTCTCAT CCCTCCTGGG GCAGCTTTCT GGACAGGTCC GTCTCCTCCT TGGGGCCCTG 660 CAGAGCCTCC TTGGAACCCA GCTTCCTCCA CAGGGCAGGA CCACAGCTCA CAAGGATCCC 720 AATGCCATCT TCCTGAGCTT CCAACACCTG CTCCGAGGAA AGGTGCGTTT CCTGATGCTT 780 GTAGGAGGGT CCACCCTCTG CGTCAGGGAA TTCGGCGGCA ACATGGCGTC TCCCGCTCCG 840 CCTGCTTGTG ACCTCCGAGT CCTCAGTAAA CTGCTTCGTG ACTCCCATGT CCTTCACAGC 900 AGACTGAGCC AGTGCCCA 918

(2)序列編號NO: 42資料： (i)序列特性： O:\92\92747.DOC 25- 200413407 (A) 長度：918鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 42 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTGCACCT 60 TTGCTGGACC CGAACAACCT CAATGACGAA GACGTCTCTA TCCTGATGGA CCGAAACCTT 120 CGACTTCCAA ACCTGGAGAG CTTCGTAAGG GCTGTCAAGA ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGTT GCCTACACCT GTCCTGCTGC CTGCTGTGGA CTTTAGCTTG 480 GGAGAATGGA AAACCCAGAT GGAGGAGACC AAGGCACAGG ACATTCTGC3G AGCAGTGACC 540 CTTCTGCTGG AGGGAGTGAT GGCAGCACGG GGACAACTGG GACCCACTTG CCTCTCATCC 600 CTCCTGGGGC AGCTTTCTGG ACAGGTCCGT CTCCTCCTTG GGGCCCTGCA GAGCCTCCTT 660 GGAACCCAGC TTCCTCCACA GGGCAGGACC ACAGCTCACA AGGATCCCAA TGCCATCTTC 720 CTGAGCITCC AACACCTGCT CCGAGGAAAG GTGCGTTTCC TGATGCITGT AGGAGGGTCC 780 ACCCTCTGCG TCAGGGAATT CGGCGGCAAC ATGGCGTCTC CCGCTCCGCC TGCTTGTGAC 840 CTCCGAGTCC TCAGTAAACT GCTTCGTGAC TCCCATGTCC TTCACAGCAG ACTGAGCCAG 900 TGCCCAGAGG TTCACCCT 918

(2)序列編號NO: 43資料： (i)序列特性： (A) 長度：918鹼基對

(B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 43 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTGCACCT 60 nGCTGGACC CGAACAACCT CAATGACGAA GACGTCTCTA TCCTGATGGA CCGAAACCTT 120 CGACTTCCAA ACCTGGAGAG CTTCGTAAGG GCTGTCAAGA ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCCCGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGT CCTGCTGCCT GCTGTGGACT TTAGCTTGGG AGAATGGAAA 480 ACCCAGATGG AGGAGACCAA GGCACAGGAC ATTCTGGGAG CAGTGACCCT TCTGCTGGAG 540 GGAGTGATGG CAGCACGGGG ACAACTGGGA CCCACTTGCC TCTCATCCCT CCTGGGGCAG 600 CTTTCTGGAC AGGTCCGTCT CCTCCTTGGG GCCCTGCAGA GCCTCCTTGG AACCCAGCTT 660 CCTCCACAGG GCAGGACCAC AGCTCACAAG GATCCCAATG CCATCTTCCT GAGCTTCCAA 720 CACCTGCTCC GAGGAAAGGT GCGTTTCCTG ATGCTTGTAG GAGGGTCCAC CCTCTGCGTC 780 O:\92\92747.DOC -26- 200413407

AGGGAATTCG

AGTAAACTGC

CACCCTTTGC

GCGGCAACAT

TTCGTGACTC

CTACACCT

GGCGTCTCCC

CCATGTCCTT

GCTCCGCCTG

CACAGCAGAC

CTTGTGACCT

TGAGCCAGTG

CCGAGTCCTC

CCCAGAOHT 840 900 918 (2)序列編號NO: 44資料： (i)序列特性： (A)長度：918鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 44 GCTAACTGCT CTATAATGAT CGATGAMTT ATACATCACT TAAAGAGACC ACCTGCACCT 60 TTGCTGGACC CGAACAACCT CAATGACGAA GACGTCTCTA TCCTGATGGA CCGAAACCTT 120 CGACTTCCAA ACCTGGAGAG CTTCGTAAGG GCTGTCAAGA ACTTAGAAAA TGCATCAGGT 180 mGkGGCkk TICnCGTkA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCITGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC TGTGGACTTT AGCITGGGAG AATGGAAAAC CCAGATGGAG 480 GAGACCAAGG CACAGGACAT TCTGGGAGCA GTGACCCTTC TGCTGGAGGG AGTGATGGCA 540 GCACGGGGAC AACTGGGACC CACTTGCCTC TCATCCCTCC TGGGGCAGCT TTCTGGACAG 600 GTCCGTCTCC TCCTTGGGGC CCTGCAGAGC CTCCTTGGAA CCCAGCITCC TCCACAGGGC 660 AGGACCACAG CTCACAAGGA TCCCAATGCC ATCTTCCTGA GCTTCCAACA CCTGCTCCGA 720 GGAAAGGTGC GTTTCCTGAT GCTTGTAGGA GGGTCCACCC TCTGCGTCAG GGAATTCGGC 780 GGCAACATGG CGTCTCCCGC TCCC5CCTGCT TGTGACCTCC GAGTCCTCAG TAAACTGCTT 840 CGTGACTCCC ATGTCCTTCA CAGCAGACTG AGCCAGTGCC CAGAGGTTCA CCCTITGCCT 900 ACACCTGTCC TGCTGCCT 918 (2)序列編號NO: 45資料： (i)序列特性： (A)長度：918鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 45 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTGCACCT 60 TTGCTGGACC CGAACAACCT CAATGACGAA GACGTCTCTA TCCTGATGGA CCGAAACCTT 120 CGACTTCCAA ACCTGGAGAG CTTCGTAAGG GCTGTCAAGA ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300

O:\92\92747.DOC -27- 200413407 TAGAGGGCGG TGGAGGCTCC 360 CTCCTCCGTC TAAAGAATCT 420 AAACCCAGAT GGAGGAGACC 480 AGGGAGTGAT GGCAGCACGG 540 AGCTTTCTGG ACAGGTCCGT 600 TTCCTCCACA GGGCAGGACC 660 AACACCTGCT CCGAGGAAAG 720 TCAGGGAAn CGGCGGCAAC 780 TCAGTAAACT GCTTCGTGAC 840 TTCACCCTTT GCCTACACCT 900 918 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CATAAATCTC CAAACATGGA CnTAGCTTG GGAGAATGGA AAGGCACAGG ACATTCTGGG AGCAGTGACC CTTCTGCTGG GGACAACTGG GACCCACTTG CCTCTCATCC CTCCTGGGGC CTCCTCCTTG GGGCCCTGCA GAGCCTCCTT GGAACCCAGC ACAGCTCACA AGGATCCCAA TGCCATCTTC CTGAGCTTCC GTGCGTTTCC TGATGCITGT AGGAGGGTCC ACCCTCTGCG ATGGCGTCTC CCGCTCCGCC TGCTTGTGAC CTCCGAGTCC TCCCATGTCC TTCACAGCAG ACTGAGCCAG TGCCCAGAGG GTCCTGCTGC CTGCTGTG (2)序列編號NO: 46資料： ⑴序列特性： (A) 長度：907鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 46

GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT

TTGCTGGACC CGAACAACCT CAATGACGAA GACGTCTCTA

CGACTTCCAA ACCTGGAGAG CTTCGTAAGG GCTGTCAAGA

ATTGAGGCM nCTTCGTM TCTCCMCCA TGTCTGCCCT

CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT

TATCGGmC CCTTGAGCAA GCGCAGGAAC AACAGTACGT

CGGGGAACCG TCTGGTCCAA TCTCTACTAT CAACCCGTCT

TAAACTCCAA ACATGGGAGA ATGGAAAACC CAGATGGAGG

CTGGAGCAGT GACCCTTCTG CTGGAGGGAG TGATGGCAGC

CTTGCTCTCA TCCCTCCTGG GGCAGOTTC TGGACAGGTC

GCAGGCCTCC nGGAACCCA GCTTCCTCCA CAGGGCAGGA

AATGCATCTT CCTGAGCITC CAACACCTGC TCCGAGGAAA

TAGGGGGTCC ACCCTCTGCG TCAGGGAATT CGGCGGCAAC

TGCTGTGACC TCCGAGTCCT CAGTAAACTG CTTCGTGACT

CTGACCAGTG CCCAGAGGTT CACCCTTTGC CTACACCTGT

TTAGTTG (2)序列編號NO: 47資料： (i)序列特性： (A) 長度：917鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形

TAAAGAGACC ACCTGCACCT 60 TCCTGATGGA CCGAAACCTT 120 ACITAGAAAA TGCATCAGGT 180 CTGCCACGGC CGCACCCTCT 240 TCCGGGAAAA ACTGACGTTC 300 AGAGGGCGGT GGAGGCTCCC 360 CCTCCGTCTA AAGAATCTCA 420 AGACCAAGGC ACAGGACATT 480 ACGGGGACAA CTGGGACCCA 540 CGTCTCCTCC TTGGGGCCCT 600 CCACAGCTCA CAAGGATCCC 660 GGTGCGTITC CTGATGCTTG 720 ATGGCGTCTC CCGCTCCGCC 780 CCCATGTCCT TCACAGCAGA 840 CCTGCTGCCT GCTGTGGACT 900 907

O:\92\92747.DOC -28- 200413407 (xi)序列描述：序列編號NO: 47 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTGCACCT 60 TTGCTGGACC CGAACAACCT CAATGACGAA GACGTCTCTA TCCTGATGGA CCGAAACCTT 120 CGACTTCCAA ACCTGGAGAG CTTCGTAAGG GCTGTCAAGA ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGm CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGG ACCCACTTGC CTCTCATCCC TCCTGGGGCA GCTTrCTGGA 480 CAGGTCCGTC TCCTCCTTGG GGCCCTGCAG AGCCTCCTTG GAACCCAGCT TCCTCCACAG 540 GGCAGGACCA CAGCTCACAA GGATCCCAAT GCCATCTTCC TGAGCTTCCA ACACCTGCTC 600 CGAGGAAAGG TGCGTTTCCT GATGCTTGTA GGAGGGTCCA CCCTCTGCGT CAGGGAATTC 660 GGCGGCAACA TGGCGTCTCC CGCTCCGCCT GCTTGTGACC TCCGAGTCCT CAGTAAACTG 720 CTTCGTGACT CCCATGTCCT TCACAGCAGA CTGAGCCAGT GCCCAGAGGT TCACCCTTTG 780 CCTACACCTG TCCTGCTGCC TGCTGTGGAC TTTAGCTTGG GAGAATGGAA AACCCAGATG 840 GAGGAGACCA AGGCACAGGA CATTCTGGGA GCAGTGACCC TTCTGCTGGA GGGAGTGATG 900 GCAGCACGGG GACAACT 917

(2)序列編號NO: 48資料： (i)序列特性： (A) 長度：918鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 48 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTGCACCT 60 TTGCTGGACC CGAACAACCT CAATGACGAA GACGTCTCTA TCCTGATGGA CCGAAACCTT 120 CGACTTCCAA ACCTGGAGAG CTTCGTAAGG GCTGTCAAGA ACTTAGAAAA TGCATCAGGT 180 AnGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGG AACCCAGCTT CCTCCACAGG GCAGGACCAC AGCTCACAAG 480 GATCCCAATG CCATCTTCCT GAGCTTCCAA CACCTGCTCC GAGGAAAGGT GCGTTTCCTG 540 ATGCTTGTAG GAGGGTCCAC CCTCTGCGTC AGGGAATTCG GCGGCAACAT GGCGTCTCCC 600 GCTCCGCCTG CTTGTGACCT CCGAGTCCTC AGTAAACTGC TTCGTGACTC CCATGTCCTT 660 CACAGCAGAC TGAGCCAGTG CCCAGAGCTT CACCCTTTGC CTACACCTGT CCTGCTGCCT 720 GCTGTGGACT TTAGCTTGGG AGAATGGAAA ACCCAGATGG AGGAGACCAA GGCACAGGAC 780 ATTCTGGGAG CAGTGACCCT TCTGCTGGAG GGAGTGATGG CAGCACGGGG ACAACTGGGA 840 CCCACTTGCC TCTCATCCCT CCTGGGGCAG CTTTCTGGAC AGGTCCGTCT CCTCCTTGGG 900 GCCCTGCAGA GCCTCCTT 918

(2)序列編號NO: 49資料： O:\92\92747.DOC -29- 200413407 ⑴序列特性： (A) 長度：918鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 49 GCTAACTGCT CTATAATGAT CGATGAMH ATACATCACT TAAAGAGACC ACCTGCACCT 60 TTGCTGGACC CGAACAACCT CAATGACGAA GACGTCTCTA TCCTGATGGA CCGAAACCTT 120 CGACTTCCAA ACCTGGAGAG CTTCGTAAGG GCTGTCAAGA ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGCSGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGG CAGGACCACA GCTCACAAGG ATCCCAATGC CATCTTCCTG 480 AGCTTCCAAC ACCTGCTCCG AGGAAAGGTG CGTTTCCTGA TGCTTGTAGG AGGGTCCACC 540 CTCTGCGTCA GGGAATTCGG CGGCAACATG GCGTCTCCCG CTCCGCCTGC TTGTGACCTC 600 CGAGTCCTCA GTAAACTGCT TCGTGACTCC CATGTCCTTC ACAGCAGACT GAGCCAGTGC 660 CCAGAGGTTC ACCCITTGCC TACACCTGTC CTGCTGCCTG CTGTGGACTT TAGCTTGGGA 720 GAATGGAAAA CCCAGATGGA GGAGACCAAG GCACAGGACA TTCTGGGAGC AGTGACCCTT 780 CTGCTGGAGG GAGTGATGGC AGCACGGGGA CAACTGGGAC CCACTTGCCT CTCATCCCTC 840 CTGGGGCAGC TTTCTGGACA GGTCCGTCTC CTCCTTGGGG CCCTGCAGAG CCTCCTTGGA 900 ACCCAGCTTC CTCCACAG 918 (2)序列編號NO: 50資料： (i)序列特性： (A) 長度：918鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 50 GCTAACTGCT CTATAATGAT CGATGAMIT ATACATCACT TAAAGAGACC ACCTGCACCT 60 TTGCTGGACC CGAACAACCT CAATGACGAA GACGTCTCTA TCCTGATGGA CCGAAACCTT 120 CGACTTCCAA ACCTGGAGAG CTTCGTAAGG GCTGTCAAGA ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC TCACAAGGAT CCCAATGCCA TCTTCCTGAG CTTCCAACAC 480 CTGCTCCGAG GAAAGGTGCG TTTCCTGATG CTTGTAGGAG GGTCCACCCT CTGCGTCAGG 540 GAATTCGGCG GCAACATGGC GTCTCCCGCT CCGCCTGCTT GTGACCTCCG AGTCCTCAGT 600 AAACTGCTTC GTGACTCCCA TGTCCTTCAC AGCAGACTGA GCCAGTGCCC AGAGGTTCAC 660 O:\92\92747.DOC -30- 200413407 CCITTGCCTA CACCTGTCCT GCTGCCTGCT GTGGACTITA GCTTGGGAGA ATGGAAAACC m CAGATGGAGG AGACCAAGGC ACAGGACATT CTGGGAGCAG TGACCCTTCT GCTGGAGGGA 780 GTGATGGCAG CACGGGGACA ACTGGGACCC ACTTGCCTCT CATCCCTCCT GGGGCAGCTT 840 TCTGGACAGG TCCGTCTCCT CCTTGGGGCC CTGCAGAGCC TCCTTGGAAC CCAGCTTCCT 900 CCACAGGGCA GGACCACA 918 (2)序列編號NO.· 51資料： (i)序列特性： (A)長度：918鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 51 GCTAACTGCT CTATAATGAT CGATGAMH ATACATCACT TAAAGAGACC ACCTGCACCT 60 TTGCTCjGACC CGAACAACCT CAATGACGAA GACGTCTCTA TCCTGATGGA CCGAAACCTT 120 CGACTTCCAA ACCTGGAGAG CTTCGTAAGG GCTGTCAAGA ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTM TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGA TCCCAATGCC ATCTTCCTGA GCTTCCAACA CCTGCTCCGA 480 GGAAAGGTGC GTTTCCTGAT GCTTGTAGGA GGGTCCACCC TCTGCGTCAG GGAATTCGGC 540 GGCAACATGG CGTCTCCCGC TCCGCCTGCT TGTGACCTCC GAGTCCTCAG TAAACTGCTT 600 CGTGACTCCC ATGTCCTTCA CAGCAGACTG AGCCAGTGCC CAGAGGTTCA CCCTTTGCCT 660 ACACCTGTCC TGCTGCCTGC TGTGGACTTT AGCTTGGGAG AATGGAAAAC CCAGATGGAG 720 GAGACCAAGG CACAGGACAT TCTGGGAGCA GTGACCCTTC TGCTGGACXjG AGTGATGGCA 780 GCACGGGGAC AACTGGGACC CACTTGCCTC TCATCCCTCC TGGGGCAGCT TTCTGGACAG 840 GTCCGTCTCC TCCTTGGGGC CCTGCAGAGC CTCCTTGGAA CCCAGCTTCC TCCACAGGGC 900 AGGACCACAG CTCACAAG 918 (2)序列編號NO: 52資料： (i)序列特性： (A)長度：918鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 52 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTGCACCT 60 TTGCTGGACC CGAACAACCT CAATGACGAA GACGTCTCTA TCCTGATGGA CCGAAACCTT 120 CGACTTCCAA ACCTGGAGAG CTTCGTAAGG GCTGTCAAGA ACTTAGAAAA TGCATCAGGT 180

O:\92\92747.DOC -31- 200413407 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGACSGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CATCTTCCTG AGCTTCCAAC ACCTGCTCCG AGGAAAGGTG 480 CGTTTCCTGA TGCTTGTAGG AGGGTCCACC CTCTGCGTCA GGGAATTCGG CGGCAACATG 540 GCGTCTCCCG CTCCGCCTGC nGTGACCTC CGAGTCCTCA GTAAACTGCT TCGTGACTCC 600 CATGTCCTTC ACAGCAGACT GAGCCAGTGC CCAGAGGTTC ACCCTTTGCC TACACCTGTC 660 CTGCTGCCTG CTGTGGACTT TAGCTTGGGA GAATGGAAAA cCCAGATGGA GGAGACCAAG 720 GCACAGGACA TTCTGGGAGC AGTGACCCIT CTGCTGGAGG GAGTGATGGC AGCACGGGGA 780 CAACTGGGAC CCACTTGCCT CTCATCCCTC CTGGGGCAGC TTTCTGGACA GGTCCGTCTC 840 CTCCTTGGGG CCCTGCAGAG CCTCCTTGGA ACCCAGCTTC CTCCACAGGG CAGGACCACA 900

GCTCACAAGG ATCCCAAT 918 (2)序列編號NO: 53資料：

⑴序列特性： (A) 長度：915鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 53 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTGCACCT 60 TTGCTGGACC CGAACAACCT CAATGACGAA GACGTCTCTA TCCTGATGGA CCGAAACCTT 120 CGACTTCCAA ACCTGGAGAG CITCGTAAGG GCTGTCAAGA ACTTAGAAAA TGCATCAGGT 180 mGkGGCkk TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGA GGTTCACCCT TTGCCTACAC CTGTCCTGCT GCCTGCTGTG 480 GACTTTAGCT TGGGAGAATG GAAAACCCAG ATGGAGGAGA CCAAGGCACA GGACATTCTG 540 GGAGCAGTGA CCCTTCTGCT GGAGGGAGTG ATGGCAGCAC GGGGACAACT GGGACCCACT 600 TGCCTCTCAT CCCTCCTGGG GCAGCTTTCT GGACAGGTCC GTCTCCTCCT TGGGGCCCTG 660 CAGAGCCTCC TTGGAACCCA GCTTCCTCCA CAGGGCAGGA CCACAGCTCA CAAGGATCCC 720 AATGCCATCT TCCTGAGCTT CCAACACCTG CTCCGAGGAA AGGTGCGTTT CCTGATGCIT 780 GTAGGAGGGT CCACCCTCTG CGTCAGGGAA TTCGGCAACA TGGCGTCTCC CGCTCCGCCT 840 GCTTGTGACC TCCGAGTCCT CAGTAAACTG CTTCGTGACT CCCATGTCCT TCACAGCAGA 900 CTGAGCCAGT GCCCA 915

(2)序列編號NO: 54資料： (i)序列特性： (A) 長度：915鹼基對 (B) 形式：核酸 (C) 股數：單 O:\92\92747.DOC -32- 200413407 (D)拓撲結構：線形 (xi)序列描述：序列編號NO: 54 GCTAACTGCT CTATAATGAT CGATGAMH ATACATCACT TAAAGAGACC ACCTGCACCT 60 TTGCTGGACC CGAACAACCT CAATGACGAA GACGTCTCTA TCCTGATGGA CCGAAACCTT 120 CGACTTCCAA ACCTGGAGAG CTTCGTAAGG GCTGTCAAGA ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 tatctgg™ CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGC5GTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGTT GCCTACACCT GTCCTGCTGC CTGCTGTGGA CITTAGCTTG 480 GGAGAATGGA AAACCCAGAT GGAGGAGACC AAGGCACAGG ACATTCTGGG AGCAGTGACC 540 CTTCTGCTGG AGGGAGTGAT GGCAGCACGG GGACAACTGG GACCCACTTG CCTCTCATCC 600 CTCCTGGGGC AGCTTTCTGG ACAGGTCCGT CTCCTCCTTG GGGCCCTGCA GAGCCTCCTT 660 GGAACCCAGC TTCCTCCACA GGGCAGGACC ACAGCTCACA AGGATCCCAA TGCCATCTTC 720 CTGAGCTTCC AACACCTGCT CCGAGGAAAG GTGCGTTTCC TGATGCTTGT AGGAGGGTCC 780 ACCCTCTGCG TCAGGGAATT CGGCAACATG GCGTCTCCCG CTCCGCCTGC TTGTGACCTC 840 CGAGTCCTCA GTAAACTGCT TCGTGACTCC CATGTCCTTC ACAGCAGACT GAGCCAGTGC 900 CCAGAGGTTC ACCCT 915

(2)序列編號NO: 55資料： (i)序列特性： (A) 長度：915鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形

(xi)序列描述：序列編號NO: 55 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTGCACCT 60 TTGCTGGACC CGAACAACCT CAATGACGAA GACGTCTCTA TCCTGATGGA CCGAAACCTT 120 CGACTTCCAA ACCTCGAGAG CTTCGTAAGG GCTGTCAAGA ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGT CCTGCTGCCT GCTGTGGACT TTAGCTTGGG AGAATGGAAA 480 ACCCAGATGG AGGAGACCAA GGCACAGGAC ATTCTGGGAG CAGTGACCCT TCTGCTGGAG 540 GGAGTGATGG CAGCACGGGG ACAACTGGGA CCCACTTGCC TCTCATCCCT CCTGGGGCAG 600 CTTTCTGGAC AGGTCCGTCT CCTCCTTGGG GCCCTGCAGA GCCTCCTTGG AACCCAGCTT 660 CCTCCACAGG GCAGGACCAC AGCTCACAAG GATCCCAATG CCATCTTCCT GAGCTTCCAA 720 CACCTGCTCC GAGGAAAGGT GCGTTTCCTG ATGCITGTAG GAGGGTCCAC CCTCTGCGTC 780 AGGGAATTCG GCAACATGGC GTCTCCCGCT CCGCCTGCTT GTGACCTCCG AGTCCTCAGT 840 AAACTGCTTC GTGACTCCCA TGTCCTTCAC AGCAGACTGA GCCAGTGCCC AGAGGTTCAC 900 CCTTTGCCTA CACCT 915 O:\92\92747.DOC 33- 200413407 (2)序列編號NO: 56資料： (i)序列特性： (A) 長度：915鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 56 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTGCACCT 60 TTGCTGGACC CGAACAACCT CAATGACGAA GACGTCTCTA TCCTGATGGA CCGAAACCTT 120 CGACTTCCAA ACCTGGAGAG CTTCGTAAGG GCTGTCAAGA ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGCTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC TGTGGACnT AGCTTGGGAG AATGGAAAAC CCAGATGGAG 480 GAGACCAAGG CACAGGACAT TCTGGGAGCA GTGACCCTTC TGCTGGAGGG AGTGATGGCA 540 GCACGGGGAC AACTGGGACC CACTTGCCTC TCATCCCTCC TGGGGCAGCT TTCTGGACAG 600 GTCCGTCTCC TCCTTGGGGC CCTGCAGAGC CTCCTTGGAA CCCAGCTTCC TCCACAGGGC 660 AGGACCACAG CTCACAAGGA TCCCAATGCC ATCTTCCTGA GCTTCCAACA CCTGCTCCGA 720 GGAAAGGTGC GTTTCCTGAT GCTTGTAGGA GGGTCCACCC TCTGCGTCAG GGAATTCGGC 780 AACATGGCGT CTCCCGCTCC GCCTGCTTGT GACCTCCGAG TCCTCAGTAA ACTGOTCGT 840 GACTCCCATG TCCTTCACAG CAGACTGAGC CAGTGCCCAG AGGTTCACCC TTTGCCTACA 900 CCTGTCCTGC TGCCT 915 (2)序列編號NO: 57資料： (i)序列特性： (A) 長度：915鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 57 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTGCACCT 60 TTGCTGGACC CGAACAACCT CAATGACGAA GACGTCTCTA TCCTGATGGA CCGAAACCTT 120 CGACTTCCAA ACCTGGAGAG CTTCGTAAGG GCTGTCAAGA ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 tatctgg™ CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGA CTTTAGCTTG GGAGAATGGA AAACCCAGAT GGAGGAGACC 480 AAGGCACAGG ACATTCTGGG AGCAGTGACC CTTCTGCTGG AGGGAGTGAT GGCAGCACGG 540 O:\92\92747.DOC -34- 200413407 GGACAACTGG GACCCACTTG CCTCTCATCC CTCCTGGGGC AGCTTTCTGG ACAGGTCCGT 600 CTCCTCCTTG GGGCCCTGCA GAGCCTCCTT GGAACCCAGC HCCTCCACA GGGCAGGACC 660 ACAGCTCACA AGGATCCCAA TGCCATCTTC CTGAGCTTCC AACACCTGCT CCGAGGAAAG 720 GTGCGTTTCC TGATGCTTGT AGGAGGGTCC ACCCTCTGCG TCAGGGMTT CGGCAACATG 780 GCGTCTCCCG CTCCGCCTGC TTGTGACCTC CGAGTCCTCA GTAAACTGCT TCGTGACTCC 840 CATGTCCTTC ACAGCAGACT GAGCCAGTGC CCAGAGGTTC ACCCTTTGCC TACACCTGTC 900 CTGCTGCCTG CTGTG 915 (2)序列編號NO: 58資料： ⑴序列特性： (A) 長度：915鹼基對 (B) 形式：核酸

(C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 58 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTGCACCT 60 TTGCTGGACC CGAACAACCT CAATGACGAA GACGTCTCTA TCCTGATGGA CCGAAACCTT 120 CGACTTCCAA ACCTGGAGAG CTTCGTAAGG GCTGTCAAGA ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGG AGAATGGAAA ACCCAGATGG AGGAGACCAA GGCACAGGAC 480 ATTCTGGGAG CAGTGACCCT TCTGCTGGAG GGAGTGATGG CAGCACGGGG ACAACTGGGA 540 CCCACTTGCC TCTCATCCCT CCTGGGGCAG CTTTCTGGAC AGGTCCGTCT CCTCCTTGGG 600 GCCCTGCAGA GCCTCCTTGG AACCCAGCTT CCTCCACAGG GCAGGACCAC AGCTCACAAG 660 GATCCCAATG CCATCTTCCT GAGCTTCCAA CACCTGCTCC GAGGAAAGGT GCGTTTCCTG 720 ATGCTTGTAG GAGGGTCCAC CCTCTGCGTC AGGGMTTCG GCAACATGGC GTCTCCCGCT 780 CCGCCTGCTT GTGACCTCCG AGTCCTCAGT AAACTGCTTC GTGACTCCCA TGTCCTTCAC 840 AGCACACTGA GCCAGTGCCC AGAGGTTCAC CCTTTGCCTA CACCTGTCCT GCTGCCTGCT 900 GTGGACTTTA GCTTG 915

(2)序列編號NO: 59資料： (i)序列特性： (A) 長度：915鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 59 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTGCACCT 60 O:\92\92747.DOC -35- 200413407

TTGCTGGACC CGAACAACCT CGACTTCCAA ACCTGGAGAG ATTGAGGCAA TTCTTCGTAA CGACATCCAA TCATCATCAA tatctgg™ CCCTTGAGCA CCGGGTGAAC CGTCTGGTCC CATAAATCTC CAAACATGGG CAGGTCCGTC TCCTCCTTGG GGCAGGACCA CAGCTCACAA CGAGGAAAGG TGCGTTTCCT GGCAACATGG CGTCTCCCGC CGTGACTCCC ATGTCCTTCA ACACCTGTCC TGCTGCCTGC GAGACCAAGG CACAGGACAT GCACGC5GGAC AACTG

CAATGACGAA GACGTCTCTA CTTCGTAAGG GCTGTCAAGA TCTCCAACCA TGTCTGCCCT GGCAGGTGAC TGGCAAGAAT AGCGCAGGAA CAACAGTACG AATCTCTACT ATCAACCCGT ACCCACTTGC CTCTCATCCC GGCCCTGCAG AGCCTCCTTG GGATCCCAAT GCCATCITCC GATGCTTGTA GGAGGGTCCA TCCGCCTGCT TGTGACCTCC CAGCAGACTG AGCCAGTGCC TGTGGACTTT AGCTTGGGAG TCTGGGAGCA GTGACCCTTC TCCTGATGGA CCGAAACCTT 120 ACTTAGAAAA TGCATCACGT 180 CTGCCACGGC CGCACCCTCT 240 TCCGGGAAAA ACTGACGTTC 300 TAGAGGGCGG TGGAGGCTCC 360 CTCCTCCGTC TAAAGAATCT 420 TCCTGGGGCA GCnTCTGGA 480 GAACCCAGCT TCCTCCACAG 540 TGAGCTTCCA ACACCTGCTC 600 CCCTCTGCGT CAGGGAATTC 660 GAGTCCTCAG TAAACTGCTT 720 CAGAGGTTCA CCCTTTGCCT 780 AATGGAAAAC CCAGATGGAG 840 TGCTGGAGGG AGTGATGGCA 900 915

(2)序列編號NO: 60資料： (i)序列特性： (A) 長度：915鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 60 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTGCACCT 60 TTGCTGGACC CGAACAACCT CAATGACGAA GACGTCTCTA TCCTGATGGA CCGAAACCTT 120 CGACTTCCAA ACCTGGAGAG CTTCGTAAGG GCTGTCAAGA ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGG AACCCAGCTT CCTCCACAGG •GCAGGACCAC AGCTCACAAG 480 GATCCCAATG CCATCTTCCT GAGCTTCCAA CACCTGCTCC GAGGAAAGGT GCGTTTCCTG 540 ATGCTTGTAG GAGGGTCCAC CCTCTGCGTC AGGGAATTCG GCAACATGGC GTCTCCCGCT 600 CCGCCTGCTT GTGACCTCCG AGTCCTCAGT AAACTGCTTC GTGACTCCCA TGTCCTTCAC 660 AGCAGACTGA GCCAGTGCCC AGAGGTTCAC CCITTGCCTA CACCTGTCCT GCTGCCTGCT 720 GTGGACTTTA GCTTGGGAGA ATGGAAAACC CAGATGGAGG AGACCAAGGC ACAGGACAH 780 CTGGGAGCAG TGACCCTTCT GCTGGAGGGA GTGATGGCAG CACGGGGACA ACTGGGACCC 840 ACTTGCCTCT CATCCCTCCT GGGGCAGCTT TCTGGACAGG TCCGTCTCCT CCTTGGGGCC 900 CTGCAGAGCC TCCTT 915

(2)序列編號NO: 61資料： (i)序列特性· (A) 長度：915鹼基對 (B) 形式：核酸 O:\92\92747.DOC .36- 200413407 (c)股數：單 (D)拓撲結構：線形 (xi)序列描述：序列編號NO: 61 GCTAACTGCT CTATMTGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTGCACCT 60 TTGCTGGACC CGAACAACCT CAATGACGAA GACGTCTCTA TCCTGATGGA CCGAAACCTT 120 CGACTTCCAA ACCTGGAGAG CTTCGTAAGG GCTGTCAAGA ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGG CAGGACCACA GCTCACAAGG ATCCCAATGC CATCTTCCTG 480 AGCTTCCAAC ACCTGCTCCG AGGAAAGGTG CGTTTCCTGA TGCTTGTAGG AGGGTCCACC 540 CTCTGCGTCA GGGMTTCGG CAACATGGCG TCTCCCGCTC CGCCTGCTTG TGACCTCCGA 600 GTCCTCAGTA AACTGCTTCG TGACTCCCAT GTCCTTCACA GCAGACTGAG CCAGTGCCCA 660 GAGGTTCACC CTTTGCCTAC ACCTGTCCTC CTGCCTGCTG TGGACTTTAG CTTGCGAGAA 720 TGGAAAACCC AGATGGAGGA GACCAAGGCA CAGGACATTC TGGGAGCAGT GACCCTTCTG 780 CTGGAGGGAG TGATGGCAGC ACGGGGACAA CTGGGACCCA CTTGCCTCTC ATCCCTCCTG 840 GGGCAGCTTT CTGGACAGGT CCGTCTCCTC CTTGGGGCCC TGCAGAGCCT CCTTGGAACC 900 CAGCTTCCTC CACAG 915

(2)序列編號NO: 62資料： (i)序列特性： (A) 長度：915鹼基對 (B) 形式：核酸 (C) 股數：單

(D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 62 GCTAACTGCT CTATMTGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTGCACCT. 60 TTGCTGGACC CGAACAACCT CAATGACGAA GACGTCTCTA TCCTGATGGA CCGAAACCTT 120 CGACTTCCAA ACCTGGAGAG CTTCGTAAGG GCTGTCAAGA ACITAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC TCACAAGGAT CCCAATGCCA TCTTCCTGAG CTTCCAACAC 480 CTGCTCCGAG GAAAGGTGCG TTTCCTGATG CTTGTAGGAG GGTCCACCCT CTGCGTCAGG 540 GAAHCGGCA ACATGGCGTC TCCCGCTCCG CCTGCTTGTG ACCTCCGAGT CCTCAGTAAA 600 CTGCTTCGTG ACTCCCATGT CCITCACAGC AGACTGAGCC AGTGCCCAGA GGTTCACCCT 660 TTGCCTACAC CTGTCCTGCT GCCTGCTGTG GACTTTAGCT TGGGAGAATG GAAAACCCAG 720 ATGGAGGAGA CCAAGGCACA GGACATTCTG GGAGCAGTGA CCCTTCTGCT GGAGGGAGTG 780 ATGGCAGCAC GGGGACAACT GGGACCCACT TGCCTCTCAT CCCTCCTGGG CCAGCTTTCT 840 GGACAGGTCC GTCTCCTCCT TGGGGCCCTG CAGAGCCTCC TTGGAACCCA GCTTCCTCCA %0 CAGGGCAGCA CCACA 915 O:\92\92747.DOC -37- 200413407 (2)序列編號NO: 63資料： (i)序列特性： (A) 長度：915鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 63

GCTAACTGCT CTATAATGAT CGkTGAAm ATACATCACT TAAAGAGACC ACCTGCACCT 60 mCIGGACC CGAACAACCT CAATGACGAA GACGTCTCTA TCCTGATGGA CCGAAACCIT 120 CGACTTCCAA ACCTGGAGAG CTTCGTAAGG GCTGTCAAGA ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 tatctgg™ CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGA TCCCAATGCC ATCTTCCTGA GCTTCCAACA CCTGCTCCGA 480 GGAAAGGTGC GTTTCCTGAT GCTTGTAGGA GGGTCCACCC TCTGCGTCAG GGAATTCGGC 540 AACATGGCGT CTCCCGCTCC GCCTGCTTGT GACCTCCGAG TCCTCAGTAA ACTGCTTCGT 600 GACTCCCATG TCCTTCACAG CAGACTGAGC CAGTGCCCAG AGGTTCACCC TTTGCCTACA 660 CCTGTCCTGC TGCCTGCTGT GGACTTTAGC TTGGGAGAAT GGAAAACCCA GATGGAGGAG 720 ACCAAGGCAC AGGACATTCT GGGAGCAGTG ACCCTTCTGC TGGAGGGAGT GATGGCAGCA 780 CGGGGACAAC TGGGACCCAC TTGCCTCTCA TCCCTCCTGG GGCAGCTTTC TGGACAGGTC 840 CGTCTCCTCC TTGGGGCCCT GCAGAGCCTC CTTGGAACCC AGCTTCCTCC ACAGGGCAGG 900 ACCACAGCTC ACAAG 915 (2)序列編號NO: 64資料： (i)序列特性· (A)長度：915鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 64 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTGCACCT 60 TTGCTGGACC CGAACAACCT CAATGACGAA GACGTCTCTA TCCTGATGGA CCGAAACCIT 120 CGACTTCCAA ACCTGGAGAG CTTCGTAAGG GCTGTCAAGA ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 tatctgg™ CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 O:\92\92747.DOC -38- 200413407 CATAAATCTC CAAACATGGC CATCTTCCTG AGCTTCCAAC ACCTGCTCCG AGGAAAGGTG 480 CGTTTCCTGA TGCTTGTAGG AGGGTCCACC CTCTGCGTCA GGGAATTCGG CAACATGGCG 540 TCTCCCGCTC CGCCTGCTTG TGACCTCCGA GTCCTCAGTA AACTGCTTCG TGACTCCCAT 600 GTCCTTCACA GCAGACTGAG CCAGTGCCCA GAGGTTCACC CTITGCCTAC ACCTGTCCTG 660 CTGCCTGCTG TGGACTTTAG CTTGGGAGAA TGGAAAACCC AGATGGAGGA GACCAAGGCA 720 CAGGACATTC TGGGAGCAGT GACCdTCTG CTGGAGGGAG TGATGGCAGC ACGGGGACAA 780 CTGGGACCCA CTTGCCTCTC ATCCCTCCTG GGGCAGCITT CTGGACAGGT CCGTCTCCTC 840 CTTGGGGCCC TGCAGAGCCT CCTTGGAACC CAGCTTCCTC CACAGGGCAG GACCACAGCT 900

CACAAGGATC CCAAT 915 (2)序列編號NO: 65資料： (i)序列特性： (A) 長度：921鹼基對

(B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 65 GCTAACTGCT CTATAATGAT CGkTGkkm ATACATCACT TAAAGAGACC ACCTGCACCT 60 TTGCTGGACC CGAACAACCT CAATGACGAA GACGTCTCTA TCCTGATGGA CCGAAACCTT 120 GACTTCCAAA CCTGGAGAGC TTCGTAAGGG CTGTCAAGAA CTTAGAAAAT GCATCAGGTA 180 TGAGGCMIT CTTCGTAATC TCCAACCATG TCTGCCCTCT GCCACGGCCG CACCCTCTCG 240 CATCCAATCA TCATCAAGGC AGGTGACTGG CAAGAATTCC GGGAAAAACT GACGHCTAT 300 TGGmCCCT TGAGCAAGCG CAGGAACAAC AGTACGTAGA GGGCGGTCGA GGCTCCCCGG 360 TAACCGTCTG GTCCAATCTC TACTATCAAC CCGTCTCCTC CGTCTAAAGA ATCTCATAAA 420 TCTCCAAACA TGGAGGTTCA CCCTTTGCCT ACACCTGTCC TGCTGCCTGC TGTGGACTTT 480 AGCTTGGGAG AATGGAAAAC CCAGATGGAG GAGACCAAGG CACAGGACAT TCTGGGAGCA 540 GTGACCCTTC TGCTGGAGGG AGTGATGGCA GCACGGCXjAC AACTGGGACC CACTTGCCTC 600 TCATCCCTCC TGGGGCAGCT TTCTGGACAG GTCCGTCTCC TCCTTGGGGC CCTGCAGAGC 660 CTCCTTGGAA CCCAGCTTCC TCCACAGGGC AGGACCACAG CTCACAAGGA TCCCAATGCC 720 ATCTTCCTGA GCTTCCAACA CCTGCTCCGA GGAAAGGTGC GTTTCCTGAT GCTTGTAGGA 780 GGGTCCACCC TCTGCGTCAG GGAATTCGGC GGCAACGGCG GCAACATGGC GTCCCCAGCG 840 CCGCCTGCTT GTGACCTCCG AGTCCTCAGT AAACTGCTTC GTGACTCCCA TGTCCTTCAC 900 AGCAGACTGA GCCAGTGCCC A 921

(2)序列編號NO: 66資料： (i)序列特性： (A) 長度：927鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 66 O:\92\92747.DOC -39 200413407 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TTGCTGGACC CGAACAACCT CAATGACGAA GACGTCTCTA CGACTTCCM ACCTGGAGAG CTTCGTAAGG GCTGTCAAGA ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CATAAATCTC CAAACATGn GCCTACACCT GTCCTGCTGC GGAGAATGGA AAACCCAGAT GGAGGAGACC AAGGCACAGG CTTCTGCTGG AGGGAGTGAT GGCAGCACGG GGACAACTGG CTCCTGGGGC AGCmCTGG ACAGGTCCGT CTCCTCCTTG GGAACCCAGC TTCCTCCACA GGGCAGGACC ACAGCTCACA CTGAGCTTCC AACACCTGCT CCGAGGAAAG GTGCGTTTCC ACCCTCTGCG TCAGGGAATT CGGCGGCAAC GGCGGCAACA GCTTGTGACC TCCGAGTCCT CAGTAAACTG CTTCGTGACT CTGAGCCAGT GCCCAGAGGT TCACCCT (2)序列編號NO: 67資料： (i)序列特性： (A) 長度：927鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 67

GCTAACTGCT CTATAATGAT CGATGAAAn ATACATCACT

nGCTGGACC CGAACAACCT CAATGACGAA GACGTCTCTA

CGACTTCCM ACCTGGAGAG CTTCGTAAGG GCTGTCAAGA

AHGAGGCM TTCTTCGTAA TCTCCAACCA TGTCTGCCCT

CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT

TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG

CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT

CATAAATCTC CAAACATGGT CCTGCTGCCT GCTCTGGACT

ACCCAGATGG AGGAGACCAA GGCACAGGAC ATTCTGGGAG

GGAGTGATGG CAGCACGC5GG ACAACTGGGA CCCACTTGCC

CTTTCTGGAC AGGTCCGTCT CCTCCTTGC5G GCCCTGCAGA

CCTCCACAGG GCAGGACCAC AGCTCACAAG GATCCCAATG

CACCTGCTCC GAGGAAAGGT GCGTTTCCTG ATGCTTGTAG

AGGGAATTCG GCGGCAACGG CGGCAACATG GCGTCCCCAG

CGAGTCCTCA GTAAACTGCT TCGTGACTCC CATGTCCTTC

CCAGAGGTTC ACCCTTTGCC TACACCT (2)序列編號NO: 68資料： (i)序列特性： TAAAGAGACC ACCTGCACCT 60 TCCTGATGGA CCGAAACCTT 120 ACTTAGAAAA TGCATCAGGT 180 CTGCCACGGC CGCACCCTCT 240 TCCGGGAAAA ACTGACGTTC 300 TAGAGGGCGG TGGAGGCTCC 360 CTCCTCCGTC TAAAGAATCT 420 CTGCTGTGGA CTTTAGCTTG 480 ACATTCTGGG AGCAGTGACC 540 GACCCACTTG CCTCTCATCC 600 GGGCCCTGCA GAGCCTCCTT 660 AGGATCCCAA TGCCATCTTC 720 TGATGCTTGT AGGAGGGTCC 780 TGGCGTCCCC AGCGCCGCCT 840 CCCATGTCCT TCACAGCAGA 900 927

TAAAGAGACC ACCTGCACCT 60 TCCTGATGGA CCGAAACCTT 120 ACTTAGAAAA TGCATCAGGT 180 CTGCCACGGC CGCACCCTCT 240 TCCGGGAAAA ACTGACGTTC 300 TAGAGGGCGG TGGAGGCTCC 360 CTCCTCCGTC TAAAGAATCT 420 TTAGCTTGGG AGAATGGAAA 480 CAGTGACCCT TCTGCTGGAG 540 TCTCATCCCT CCTGGGGCAG 600 GCCTCCTTGG AACCCAGCTT 660 CCATCTTCCT GAGCTTCCAA 720 GAGGGTCCAC CCTCTGCGTC 780 CGCCGCCTGC TTGTGACCTC 840 ACAGCAGACT GAGCCAGTGC 900 927

O:\92\92747.DOC 40- 200413407 (A) 長度：927鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 68 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTGCACCT 60 TTGCTGGACC CGAACAACCT CAATGACGAA GACGTCTCTA TCCTGATGGA CCGAAACCTT 120 CGACTTCCAA ACCTGGAGAG CTTCGTAAGG GCTGTCAAGA ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC TGTGGACITT AGCTTGGGAG AATGGAAAAC CCAGATGGAG 480 GAGACCAAGG CACAGGACAT TCTGGGAGCA GTGACCCTTC TGCTGGAGGG AGTGATGGCA 540 GCACGGGGAC AACTGGGACC CACTTGCCTC TCATCCCTCC TGGGGCAGCT TTCTGGACAG 600 GTCCGTCTCC TCCTTGGGGC CCTGCAGAGC CTCCTTGGAA CCCAGOTCC TCCACAGGGC 660 AGGACCACAG CTCACAAGGA TCCCAATGCC ATCTTCCTGA GCTTCCAACA CCTGCTCCGA 720 GGAAAGGTGC GTTTCCTGAT GCTTGTAGGA GGGTCCACCC TCTGCGTCAG GGAATTCGGC 780 GGCAACGGCG GCAACATGGC GTCCCCAGCG CCGCCTGCTT GTGACCTCCG AGTCCTCAGT 840 AAACTGCTTC GTGACTCCCA TGTCCTTCAC AGCAGACTGA GCCAGTGCCC AGAGGTTCAC 900

CCTTTGCCTA CACCTGTCCT GCTGCCT 927 (2)序列編號NO·· 69資料： (i)序列特性： (A) 長度：927鹼基對

(B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 69 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTGCACCT 60 TTGCTGGACC CGAACAACCT CAATGACGAA GACGTCTCTA TCCTGATGGA CCGAAACCTT 120 CGACTTCCAA ACCTGGAGAG CTTCGTAAGG GCTGTCAAGA ACTTAGAAAA TGCATCAGGT 180 AHGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGA CTTTAGCTTG GGAGAATGGA AAACCCAGAT GGAGGAGACC 480 AAGGCACAGG ACATTCTGGG AGCAGTGACC CTTCTGCTGG AGGGAGTGAT GGCAGCACGG 540 GGACAACTGG GACCCACTTG CCTCTCATCC CTCCTGGGGC AGCTTTCTGG ACAGGTCCGT 600 CTCCTCCTTG GGGCCCTGCA GAGCCTCCTT GGAACCCAGC TTCCTCCACA GGGCAGGACC 660 ACAGCTCACA AGGATCCCAA TGCCATCTTC CTGAGCTTCC AACACCTGCT CCGAGGAAAG 720 GTGCGTTTCC TGATGCTTGT AGGAGGGTCC ACCCTCTGCG TCAGGGAAU CGGCGGCAAC 780 O:\92\92747.DOC -41· 200413407

GGCGGCAACA TGGCGTCCCC AGCGCCGCCT GCTTGTGACC TCCGAGTCCT CAGTAAACTG CTTCGTGACT CCCATGTCCT TCACAGCAGA CTGAGCCAGT GCCCAGAGGT TCACCCTTTG CCTACACCTG TCCTGCTGCC TGCTGTG (2)序列編5虎N 0: 70資料： (i)序列特性： (A)長度：927鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 70 GCTAACTGCT CTATAATGAT CGATGAMTT ATACATCACT TAAAGAGACC ACCTGCACCT TTGCTGGACC CGAACAACCT CAATGACGAn GACGTCTCTA TCCTGATGGA CCGAAACCTT CGACTTCCAA ACCTGGAGAG CTTCGTAAGG GCTGTCAAGA ACTTAGAAAA TGCATCAGGT ATTGAGGCM TTCTTCGTM TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT CATAAATCTC CAAACATGGG AGAATGGAAA ACCCAGATGG AGGAGACCAA GGCACAGGAC ATTCTGGGAG CAGTGACCCT TCTGCTGGAG GGAGTGATGG CAGCACGGGG ACAACTGGGA CCCACTTGCC TCTCATCCCT CCTGGGGCAG CnTCTGGAC AGGTCCGTCT CCTCCTTGGG GCCCTGCAGA GCCTCCTTGG AACCCAGCTT CCTCCACAGG GCAGGACCAC AGCTCACAAG GATCCCAATG CCATCTTCCT GAGCTTCCAA CACCTGCTCC GAGGAAAGGT GCGTTTCCTG ATGCTTGTAG GAGGGTCCAC CCTCTGCGTC AGGGAATTCG GCGGCAACGG CGGCAACATG GCGTCCCCAG CGCCGCCTGC nGTGACCTC CGAGTCCTCA GTAAACTGCT TCGTGACTCC CATGTCCTTC ACAGCAGACT GAGCCAGTGC CCAGAGGTTC ACCCITTGCC TACACCTGTC CTGCTGCCTG CTGTGGACTT TAGCTTG (2)序列編號NO: 71資料： (i)序列特性： (A)長度：927鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 71 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTGCACCT TTGCTGGACC CGAACAACCT CAATGACGAA GACGTCTCTA TCCTGATGGA CCGAAACCTT CGACTTCCAA ACCTGGAGAG CTTCGTAAGG GCTGTCAAGA ACTTAGAAAA TGCATCAGGT ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 840 900 927

60 120 180 240 300 360 420 480 540 600 660 720 780 840 900 927 60 120 180 240 300

O:\92\92747.DOC 42- 200413407 tatctgg™ CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGG ACCCACITGC CTCTCATCCC TCCTGC5GGCA GCTTTCTGGA 480 CAGGTCCGTC TCCTCCTTGG GGCCCTGCAG AGCCTCCTTG GAACCCAGCT TCCTCCACAG 540 GGCAGGACCA CAGCTCACAA GGATCCCAAT GCCATCTTCC TGAGCTTCCA ACACCTGCTC 600 CGAGGAAAGG TGCGTTTCCT GATGCTTGTA GGAGGGTCCA CCCTCTGCGT CAGGGAATTC 660 GGCGGCAACG GCGGCAACAT GGCGTCCCCA GCGCCGCCTG CTTGTGACCT CCGAGTCCTC 720 AGTAAACTGC TTCGTGACTC CCATGTCCTT CACAGCAGAC TGAGCCAGTG CCCAGAGGTT 780 CACCCTTTGC CTACACCTGT CCTGCTGCCT GCTGTGGACT TTAGCTTGGG AGAATGGAAA 840 ACCCAGATGG AGGAGACCAA GGCACAGGAC AnCTGGGAG CAGTGACCCT TCTGCTGGAG 900

GGAGTGATGG CAGCACGGGG ACAACTG 927 (2)序列編號NO: 72資料： (i)序列特性：

(A) 長度：927鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 72 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTGCACCT 60 TTGCTGGACC CGAACAACCT CAATGACGAA GACGTCTCTA TCCTGATGGA CCGAAACCTT 120 CGACTTCCAA ACCTGGAGAG CTTCGTAAGG GCTGTCAAGA ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 tatctgg™ CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGG AACCCAGCTT CCTCCACAGG GCAGGACCAC AGCTCACAAG 480 GATCCCAATG CCATCTTCCT GAGCTTCCAA CACCTGCTCC GAGGAAAGGT GCGTTTCCTG 540 ATGCITGTAG GAGGGTCCAC CCTCTGCGTC AGGGAATTCG GCGGCAACGG CGGCAACATG 600 GCGTCCCCAG CGCCGCCTGC TTGTGACCTC CGAGTCCTCA GTAAACTGCT TCGTGACTCC 660 CATGTCOTC ACAGCAGACT GAGCCAGTGC CCAGAGGTTC ACCCTTTGCC TACACCTGTC 720 CTGCTGCCTG CTGTGGACTT TAGCTTGGGA GAATGGAAAA CCCAGATGGA GGAGACCAAG 780 GCACAGGACA TTCTGGGAGC AGTGACCCIT CTGCTGGAGG GAGTGATGGC AGCACGGGGA 840 CAACTGGGAC CCACTTGCCT CTCATCCCTC CTGGGGCAGC TTTCTGGACA GGTCCGTCTC 900 CTCCTTGGGG CCCTGCAGAG CCTCCTT 927

(2)序列編號NO: 73資料： (i)序列特性： (A) 長度：927鹼基對 (B) 形式：核酸 (C) 股數：單 O:\92\92747.DOC -43- 200413407 (D)拓撲結構：線形 (xi)序列描述：序列編號NO: 73 GCTAACTGCT CTATAATGAT CGATGAMTT ATACATCACT TAAAGAGACC ACCTGCACCT 60 TTGCTGGACC CGAACAACCT CAATGACGAA GACGTCTCTA TCCTGATGGA CCGAAACCTT 120 CGACTTCCAA ACCTGGAGAG CTTCGTAAGG GCTGTCAAGA ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGG CAGGACCACA GCTCACAAGG ATCCCAATGC CATCTTCCTG 480 AGCTTCCAAC ACCTGCTCCG AGGAAAGGTG CGTTTCCTGA TGCTTGTAGG AGGGTCCACC 540 CTCTGCGTCA GGGMTTCGG CGGCAACGGC GGCAACATGG CGTCCCCAGC GCCGCCTGCT 600 TGTGACCTCC GAGTCCTCAG TAAACTGCTT CGTGACTCCC ATGTCCTTCA CAGCAGACTG 660 AGCCAGTGCC CAGAGGTTCA CCCTTTGCCT ACACCTGTCC TGCTGCCTGC TGTGGACITT 720 AGCTTGGGAG AATGGAAAAC CCAGATGGAG GAGACCAAGG CACAGGACAT TCTGGGAGCA 780 GTGACCCTTC TGCTGGAGGG AGTGATGGCA GCACGGGGAC AACTGGGACC CACTTGCCTC 840 TCATCCCTCC TGGGGCAGCT TTCTGGACAG GTCCGTCTCC TCCTTGGGGC CCTGCAGAGC 900 CTCCTTGGAA CCCAGCTTCC TCCACAG 927 (2)序列編號NO: 74資料： (i)序列特性： (A)長度：927鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 '•線形 (xi)序列描述：序列編號NO: 74 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTGCACCT 60 TTGCTGGACC CGAACAACCT CAATGACGAA GACGTCTCTA TCCTGATGGA CCGAAACCTT 120 CGACTTCCAA ACCTGGAGAG CTTCGTAAGG GCTGTCAAGA ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC TCACAAGGAT CCCAATGCCA TCTTCCTGAG CTTCCAACAC 480 CTGCTCCGAG GAAAGGTGCG TTTCCTGATG CITGTAGGAG GGTCCACCCT CTGCGTCAGG 540 GAATTCGGCG GCAACGGCGG CAACATGGCG TCCCCAGCGC CGCCTGCTTG TGACCTCCGA 600 GTCCTCAGTA AACTGCTTCG TGACTCCCAT GTCCTTCACA GCAGACTGAG CCAGTGCCCA 660 GAGGTTCACC CTTTGCCTAC ACCTGTCCTG CTGCCTGCTG TGGACITTAG CTTGGGAGAA 720 TGGAAAACCC AGATGGAGGA GACCAAGGCA CAGGACATTC TGGGAGCAGT GACCCTTCTG 780 CTGGAGGGAG TGATGGCAGC ACGGCGACAA CTGGGACCCA CTTGCCTCTC ATCCCTCCTG 840 GGGCAGCITT CTGGACAGGT CCGTCTCCTC CTTGGGGCCC TGCAGAGCCT CCTTGGAACC 900 CAGCTTCCTC CACAGGGCAG GACCACA 927

O:\92\92747.DOC -44- 200413407 (2)序列編號NO: 75資料： (i)序列特性： (A) 長度：927鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 75 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTGCACCT 60 TTGCTGGACC CGAACAACCT CAATGACGAA GACGTCTCTA TCCTGATGGA CCGAAACCTT 120 CGACTTCCAA ACCTGGAGAG CTTCGTAAGG GCTGTCAAGA ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 tatctgg™ CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGA TCCCAATGCC ATCTTCCTGA GCTTCCAACA CCTGCTCCGA 480 GGAAAGGTGC GTTTCCTGAT GCTTGTAGGA GGGTCCACCC TCTGCGTCAG GGAATTCGGC 540 GGCAACGGCG GCAACATGGC GTCCCCAGCG CCGCCTGCTT GTGACCTCCG AGTCCTCAGT 600 AAACTGCTTC GTGACTCCCA TGTCCTTCAC AGCAGACTGA GCCAGTGCCC AGAGGTTCAC 660 CCTTTGCCTA CACCTGTCCT GCTGCCTGCT GTGGACTTTA GCTTGGGAGA ATGGAAAACC 720 CAGATGGAGG AGACCAAGGC kCKGGkCm CTGGGAGCAG TGACCCTTCT GCTGGAGGGA 780 GTGATGGCAG CACGGGGACA ACTGGGACCC ACTTGCCTCT CATCCCTCCT GGGGCAGCTT 840 TCTGGACAGG TCCGTCTCCT CCTTGGGGCC CTGCAGAGCC TCCTTGGAAC CCAGCTTCCT 900 CCACAGGGCA GGACCACAGC TCACAAG 927 (2)序列編號NO: 76資料： (i)序列特性： (A)長度：927鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO·. 76 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTGCACCT 60 TTGCTGGACC CGAACAACCT CAATGACGAA GACGTCTCTA TCCTGATGGA CCGAAACCTT 120 CGACTTCCAA ACCTGGAGAG CTTCGTAAGG GCTGTCAAGA ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGm CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CATCTTCCTG AGCTTCCAAC ACCTGCTCCG AGGAAAGGTG 480 CGTTTCCTGA TGCTTGTAGG AGGGTCCACC CTCTGCGTCA GGGAATTCGG CGGCAACGGC 540 O:\92\92747.DOC •45- 200413407 GGCAACATGG CGTCCCCAGC GCCGCCTGCT TGTGACCTCC GAGTCCTCAG TAAACTGCTT 600 CGTGACTCCC ATGTCCTTCA CAGCAGACTG AGCCAGTGCC CAGAGGTTCA CCCTTTGCCT 660 ACACCTGTCC TGCTGCCTGC TGTGGACTTT AGCTTGGGAG AATGGAAAAC CCAGATGGAG 720 GAGACCAAGG CACAGGACAT TCTGGGAGCA GTGACCCTTC TGCTGGAGGG AGTGATGGCA 780 GCACGGGGAC AACTGGGACC CACTTGCCTC TCATCCCTCC TGGGGCAGCT TTCTGGACAG 840 GTCCGTCTCC TCCTTGGGGC CCTGCAGAGC CTCCTTGGAA CCCAGCTTCC TCCACAGGGC 900 AGGACCACAG CTCACAAGGA TCCCAAT 927 (2)序列編號NO.· 77資料： (i)序列特性： (A)長度：906鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 77 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTGCACCT 60 TTGCTGGACC CGAACAACCT CAATGACGAA GACGTCTCTA TCCTGATGGA CCGAAACCTT 120 CGACTTCCAA ACCTGGAGAG CTTCGTAAGG GCTGTCAAGA ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTM TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGax CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGA TCCCAATGCC ATCTTCCTGA GCTTCCAACA CCTGCTCCGA 480 GGAAAGGTGC GTTTCCTGAT GCTTGTAGGA GGGTCCACCC TCTGCGTCAG GGAATTCGGC 540 GGCAACATGG CGTCTCCCGC TCCGCCTGCT TGTGACCTCC GAGTCCTCAG TAAACTGCTT 600 CGTGACTCCC ATGTCCTTCA CAGCAGACTG AGCCAGTGCC CAGAGGTTCA CCCTTTGCCT 660 ACACCTGTCC TGCTGCCTGC TGTGGACTTT AGCTTGGGAG AATGGAAAAC CCAGATGGAG 720 GAGACCAAGG CACAGGACAT TCTGGGAGCA GTGACCCTTC TGCTGGAGGG AGTGATGGCA 780 GCACGGGGAC AACTGGGACC CACTTGCCTC TCATCCCTCC TGGGGCAGCT TTCTGGACAG 840 GTCCGTCTCC TCCTTGGGGC CCTGCAGAGC CTCCTTGGAA CCCAGGGCAG GACCACAGCT 900 CACAAG 906 (2)序列編號NO: 78資料： (i)序列特性： (A)長度：993鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO_. 78 ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG ACCACCTGCA 60 O:\92\92747.DOC •46- 200413407 CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT CTATCCTGAT GGATCGAAAC 120 CTTCGACTTC CAAACCTGGA GAGCTTCGTA AGGGCTGTCA AGAACTTAGA AAATGCATCA 180 GGTATTGAGG CAKHCnCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC 240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG 300 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG CGGTGGAGGC 360 TCCCCGGGTG AACCGTCTGG TCCAATCTCT ACTATCAACC CGTCTCCTCC GTCTAAAGAA 420 TCTCATAAAT CTCCAAACAT GTCTTACAAG CTGTGCCACC CCGAGGAGCT GGTGCTGCTC 480 GGACACTCTC TGGGCATCCC CTGGGCTCCC CTGAGCTCCT GCCCCAGCCA GGCCCTGCAG 540 CTGGCAGGCT GCTTGAGCCA ACTCCATAGC GGCCTTTTCC TCTACCAGGG GCTCCTGCAG 600 GCCCTGGAAG GGATATCCCC CGAGTTGGGT CCCACCTTGG ACACACTGCA GCTGGACGTC 660 GCCGACTTTG CCACCACCAT CTGGCAGCAG ATGGAAGAAC TGGGAATGGC CCCTGCCCTG 720 CAGCCCACCC AGGGTGCCAT GCCGGCCTTC GCCTCTGCTT TCCAGCGCCG GGCAGGAGGG 780 GTCCTGCTTG CTAGCCATCT GCAGAGCITC CTGGAGGTGT CGTACCGCGT TCTACGCCAC 840 CTTGCGCAGC CCGGCGCCGG CTCTGACATG GCTACACCAT TAGGCCCTGC CAGCTCCCTG 900 CCCCAGAGCT TCCTGCTCAA GTCTTTAGAG CAAGTGAGGA AGATCCAGGG CGATGGCGCA 960 GCGCTCCAGG AGAAGCTGTG TGCCACCTAA TAA 993 (2)序列編號NO: 79資料： # (i)序列特性： (A) 長度：993鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 79 ATGGCTAACT GCTCTATAAT GATCGATGAA ATTATACATC ACTTAAAGAG ACCACCTGCA 60 CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT AGGGCTGTCA CTATCCTGAT GGATCGAAAC 120 CTTCGACTTC CAAACCTGGA GAGCTTCGTA AGAACTTAGA AAATGCATCA 180 GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC CGCCGCACCC 240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG 300 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG CGGTGGAGGC 360 TCCCCGGGTG AACCGTCTGG TCCAATCTCT ACTATCAACC CGTCTCCTCC GTCTAAAGAA 420 TCTCATAAAT CTCCAAACAT GTCTCCCGAG nGGGTCCCA CCTTGGACAC ACTGCAGCTG 480 GACGTCGCCG ACHTGCCAC CACCATCTGG CAGCAGATGG AAGAACTGGG AATGGCCCCT 540 GCCCTGCACC CCACCCAGGG TGCCATGCCG GCCTTCGCCT CTGCTTTCCA GCGCCGGGCA 600 GGAGGGGTCC TGGHGCTAG CCATCTGCAG AGCTTCCTGG AGGTGTCGTA CCGCGTTCTA 660 CGCCACCTTG CGCAGCCCGG CGGCGGCTCT GACATGGCTA CACCATTAGG CCCTGCCAGC 720 TCCCTGCCCC AGAGCITCCT GCTCAAGTCT TTAGAGCAAG TGAGGAAGAT CCAGGGCGAT 780 GGCGCAGCGC TCCAGGACAA GCTGTGTGCC ACCTACAAGC TGTGCCACCC CGAGGAGCTG 840 GTGCTGCTCG GACACTCTCT GGGCATCCCC TGGGCTCCCC TGAGCTCCTG CCCCAGCCAG 900 GCCCTGCAGC TGGCAGGCTG CTTGACCCAA CTCCATAGCG GCCTTTTCCT CTACCAGGGG 960 CTCCTGCAGG CCCTGGAAGG GATATCCTAA TAA 993

(2)序列編號NO: 80資料： (i)序列特性： O:\92\92747.DOC 47- 200413407 (A) 長度：993鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 80 ATGGCTAACT GCTCTATAAT GATCGATGAA AmTACATC ACTTAAAGAG ACCACCTGCA 60 CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT CTATCCTGAT GGATCGAAAC 120 CTTCGAGTC CAAACCTGGA GAGCTTCGTA AGGGCTGTCA AGAACTTAGA AAATGCATCA 180 GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC 240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG 300 TTCTATCTGG mCCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG CGGTGGAGGC 360 TCCCCGGGTG AACCGTCTGG TCCAATCTCT ACTATCAACC CGTCTCCTCC GTCTAAAGAA 420 TCTCATAAAT CTCCAAACAT GTCTTCTGCT TTCCAGCGCC GGGCAGGAGG GGTCCTGGTT 480 GCTAGCCATC TGCAGAGCTT CCTGGAGGTG TCGTACCGCG TTCTACGCCA CCTTGCGCAG 540 CCCGGCGGCG GCTCTGACAT GGCTACACCA TTAGGCCCTG CCAGCTCCCT GCCCCAGAGC 600 TTCCTGCTCA AGTCTTTAGA GCAAGTGAGG AAGATCCAGG GCGATGGCGC AGCGCTCCAG 660 GAGAAGCTGT GTGCCACCTA CAAGCTGTGC CACCCCGAGG AGCTGGTGCT GCTCGGACAC 720 TCTCTGGGCA TCCCCTGGGC TCCCCTGAGC TCCTGCCCCA GCCAGGCCCT GCAGCTGGCA 780 GGCTGCTTGA GCCAACTCCA TAGCGGCCTT TTCCTCTACC AGGGGCTCCT GCAGGCCCTG 840 GAAGGGATAT CCCCCGAGTT GGGTCCCACC TTGGACACAC TGCAGCTGGA CGTCGCCGAC 900 TTTGCCACCA CCATCTGGCA GCAGATGGAA GAACTGGGAA TGGCCCCTGC CCTGCAGCCC 960 ACCCAGGGTG CCATGCCGGC CTTCGCCTAA TAA 993 (2)序列編號NO: 81資料： (i)序列特性· (A) 長度：993鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 81 ATGGCTAACT GCTCTATAAT GATCGATGAA AmTACATC ACTTAAAGAG ACCACCTGCA 60 CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT CTATCCTGAT GGATCGAAAC 120 CTTCGACTTC CAAACCTGGA GAGCTTCGTA AGGGCTGTCA AGAACTTAGA AAATGCATCA 180 GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC 240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG 300 HCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG CGGTGGAGGC 360 TCCCCGGGTG AACCGTCTGG TCCAATCTCT ACTATCAACC CGTCTCCTCC GTCTAAAGAA 420 TCTCATAAAT CTCCAAACAT GTCTATGGCC CCTGCCCTGC AGCCCACCCA GGGTGCCATG 480 CCGGCCTTCG CCTCTGCTTT CCAGCGCCGG GCAGGAGGGG TCCTGGTTGC TAGCCATCTG 540 CAGAGCTTCC TGGAGGTGTC GTACCGCGH CTACGCCACC TTGCGCAGCC CGGCGGCGGC 600 TCTGACATGG CTACACCATT AGGCCCTGCC AGCTCCCTGC CCCAGAGCTT CCTGCTCAAG 660 O:\92\92747.DOC -48- 200413407 TCTTTAGAGC AAGTGAGGAA GATCCAGGGC GATGGCGCAG CGCTCCAGGA GAAGCTGTGT 720 GCCACCTACA AGCTGTGCCA CCCCGAGGAG CTGGTGCTGC TCGGACACTC TCTGGGCATC 780 CCCTGGGCTC CCCTGAGCTC CTGCCCCAGC CAGGCCCTGC AGCTGGCAGG CTGCTTGAGC 840 CAACTCCATA GCGGCCTTTT CCTCTACCAG GGGCTCCTGC AGGCCCTGGA AGGGATATCC 900 CCCGAGTTGG GTCCCACCTT GGACACACTG CAGCTGGACG TCGCCGACTT TGCCACCACC 960 ATCTGGCAGC AGATGGAAGA ACTGGGATAA TAA 993 (2)序列編號NO·· 82資料： (0序列特性： (A) 長度：993驗基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 82 ATGGCTAACT GCTCTATAAT GATCGATGAA AmTACATC ACTTAAAGAG ACCACCTGCA 60 CCTTTGCTGG ACCCGAACAA CCTCAATGAC GAAGACGTCT CTATCCTGAT GGATCGAAAC 120 CTTCGACTTC CAAACCTGGA GAGCTTCGTA AGGGCTGTCA AGAACTTAGA AAATGCATCA 180 GGTATTGAGG CAATTCTTCG TAATCTCCAA CCATGTCTGC CCTCTGCCAC GGCCGCACCC 240 TCTCGACATC CAATCATCAT CAAGGCAGGT GACTGGCAAG AATTCCGGGA AAAACTGACG 300 TTCTATCTGG TTACCCTTGA GCAAGCGCAG GAACAACAGT ACGTAGAGGG CGGTGGAGGC 360 TCCCCGGGTG AACCGTCTGG TCCAATCTCT ACTATCAACC CGTCTCCTCC GTCTAAAGAA 420 TCTCATAAAT CTCCAAACAT GTCTACCCAG GGTGCCATGC CGGCCTTCGC CTCTGCnTC 480 CAGCGCCGGG CAGGAGGGGT CCTGGTTGCT AGCCATCTGC AGAGCTTCCT GGAGGTGTCG 540 TACCGCGTTC TACGCCACCT TGCGCAGCCC GGCGGCGGCT CTGACATGGC TACACCATTA 600 GGCCCTGCCA GCTCCCTGCC CCAGAGCTTC CTGCTCAAGT CTTTAGAGCA AGTGAGGAAG 660 ATCCAGGGCG ATGGCGCAGC GCTCCAGGAG AAGCTGTGTG CCACCTACAA GCTGTGCCAC 720 CCCGAGGAGC TGGTGCTGCT CGGACACTCT CTGGGCATCC CCTGGGCTCC CCTGAGCTCC 780 TGCCCCAGCC AGGCCCTGCA GCTGGCAGGC TGCTTGAGCC AACTCCATAG CGGCCTTTTC 840 CTCTACCAGG GGCTCCTGCA GGCCCTGGAA GGGATATCCC CCGAGHGGG TCCCACCTTG 900 GACACACTGC AGCTGGACGT CGCCGACTTT GCCACCACCA TCTGGCAGCA GATGGAAGAA 960 CTGGGAATGG CCCCTGCCCT GCAGCCCTAA TAA 993 (2)序列編號NO: 83資料： (i)序列特性： (A) 長度：1027鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 83 ATGGCTACAC CATTGGGCCC TGCCAGCTCC CTGCCCCAGA GCTTCCTGCT CAAGTCTTTA 60 O:\92\92747.DOC -49- 200413407 GAGCAAGTGA GGAAGATCCA GGGCGATGGC GCAGCGCTCC AGGAGAAGCT GTGTGCCACC 120 TACAAGCTGT GCCACCCCGA GGAGCTGGTG CTGCTCGGAC ACTCTCTGGG CATCCCCTGG 180 GCTCCCCTGA GCTCCTGCCC CAGCCAGGCC CTGCAGCTGG CAGGCTGCTT GAGCCAACTC 240 CATAGCGGCC TTTTCCTCTA CCAGGGGCTC CTGCAGGCCC TGGAAGGGAT ATCCCCCGAG 300 HGGGTCCCA CCTTGGACAC ACTGCAGCTG GACGTCGCCG ACTTTGCCAC CACCATCTGG 360 CAGCAGATGG AAGAACTGGG AATGGCCCCT GCCCTGCAGC CCACCCAGGG TGCCATGCCG 420 GCCTTCGCCT CTGCTTTCCA GCGCCGGGCA GGAGGGGTCC TGGTTGCTAG CCATCTGCAG 480 AGCTTCCTGG AGGTGTCGTA CCGCGTTCTA CGCCACCTTG CGCAGCCCGG CGGCGGCTCT 540 GACATGGCTA CACCATTGGG CCCTGCCAGC TCCCTGCCCC AGAGCTTCCT GCTCAAGTCT 600 TTAGAGCAAG TGAGGAAGAT CCAGGGCGAT GGCGCAGCGC TCCAGGAGAA GCTGTGTGCC 660 ACCTACAAGC TGTGCCACCC CGAGGAGCTG GTGCTGCTCG GACACTCTCT GGGCATCCCC 720 TGGGCTCCCC TGACCTCCTG CCCCAGCCAG GCCCTGCAGC TGGCAGGCTG CTTGAGCCAA 780 CTCCATAGCG GCCTTTTCCT CTACCAGGGG CTCCTGCAGG CCCTGGAAGG GATATCCCCC 840 GAGTTGGGTC CCACCTTGGA CACACTGCAG CTGGACGTCG CCGACTTTGC CACCACCATC 900 TGGCAGCAGA TGGAAGAACT GGGAATGGCC CCTGCCCTGC AGCCCACCCA TCCTGGITGC 960 TAGCCATCTG CAGAGCTTCC TGGAGGTGTC GTACCGCGTT CTACGCCACC TTGCGCAGCC 1020 CTGATAA 1027 (2)序列編號NO: 84資料： (i)序列特性： (A) 長度：459鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 84 TCTCCCGCTC CGCCTGCTTG TGACCTCCGA GTCCTCAGTA AACTGCTTCG TGACTCCCAT 60 GTCCTTCACA GCAGACTGAG cCAGTGCCCA GAGGTTCACC CTTTGCCTAC ACCTGTCCTG 120 CTGCCTGCTG TGGACTTTAG CTTGGGAGAA TGGAAAACCC AGATGGAGGA GACCAAGGCA 180 CAGGACATTC TGGGAGCAGT GACCCTTCTG CTGGAGGGAG TGATGGCAGC ACGGC5GACAA 240 CTGGGACCCA CTTGCCTCTC ATCCCTCCTG GGGCAGCTTT CTGGACAGGT CCGTCTCCTC 300 CTTGGGGCCC TGCAGAGCCT CCTTGGAACC CAGCTTCCTC CACAGGGCAG GACCACAGCT 360 CACAAGGATC CCAATGCCAT CTTCCTGAGC TTCCAACACC TGCTCCGAGG AAAGGTGCGT 420 nCCTGATGC HGTAGGAGG GTCCACCCTC TGCGTCAGG 459 (2)序列編號NO: 85資料： (i)序列特性： (A) 長度：447鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 85 O:\92\92747.DOC -50- 200413407 TCTCCCGCTC CGCCTGCTTG TGACCTCCGA GTCCTCAGTA AACTGCTTCG TGACTCCCAT 60 GTCCTTCACA GCAGACTGAG CCAGTGCCCA GAGGTTCACC CTTTGCCTAC ACCTGTCCTG 120 CTGCCTGCTG TGGACTTTAG CTTGGGAGAA TGGAAAACCC AGATGGAGGA GACCAAGGCA 180 CAGGACATTC TGGGAGCAGT GACCCTTCTG CTGGAGGGAG TGATGGCAGC ACGGGGACAA 240 CTGGGACCCA CTTGCCTCTC ATCCCTCCTG GGGCAGCTTT CTGGACAGGT CCGTCTCCTC 300 CTTGGGGCCC TGCAGAGCCT CCTTGGAACC CAGGGCAGGA CCACAGCTCA CAAGGATCCC 360 AATGCCATCT TCCIGAGCTT CCAACACCTG CTCCGAGGAA AGGTGCGTTT CCTGATGCTT 420 GTAGGAGGGT cCACCCTCTG CGTCAGG 447 (2)序列編號NO: 86資料： (i)序列特性· (A)長度：459鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 86 TCCCCAGCGC CGCCTGCTTG TGACCTCCGA GTCCTCAGTA AACTGCTTCG TGACTCCCAT 60 GTCCTTCACA GCAGACTGAG CCAGTGCCCA GAGGTTCACC CTTTGCCTAC ACCTGTCCTG 120 CTGCCTGCTG TGGACTTTAG CTTGGGAGAA TGGAAAACCC AGATGGAGGA GACCAAGGCA 180 CAGGACATTC TGGGAGCAGT GACCCTTCTG CTGGAGGGAG TGATGGCAGC ACGGGGACAA 240 CTGGGACCCA CTTGCCTCTC ATCCCTCCTG GGGCAGCnT CTGGACAGGT CCGTCTCCTC 300 CTTGGGGCCC TGCAGAGCCT CCTTGGAACC CAGCTTCCTC CACAGGGCAG GACCACAGCT 360 CACAAGGATC CCAATGCCAT CTTCCTGAGC TTCCAACACC TGCTCCGAGG AAAGGTGCGT 420 TTCCTGATGC TTGTAGGAGG GTCCACCCTC TGCGTCAGG 459 (2)序列編號NO: 87資料： (i)序列特性： (A)長度：464鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 87 CCATGGCTAA CTGCTCTATA ATGATCGATG AMTTATACA TCACTTAAAG AGACCACCTG 60 CACCTTTGCT GGACCCGAAC AACCTCAATG ACGAAGACGT CTCTATCCTG ATGGATCGAA 120 ACCTTCGACT TCCAAACCTG GAGAGCTTCG TAAGGGCTGT CAAGAACTTA GAAAATGCAT 180 CAGGTATTGA GGCAATTCTT CGTAATCTCC AACCATGTCT GCCCTCTGCC ACGGCCGCAC 240 CCTCTCGACA TCCAATCATC ATCAAGGCAG GTGACTGGCA AGAATTCCGG GAAAAACTGA 300 CGTTCTATCT GGTTACCCTT GAGCAAGCGC AGGAACAACA GTACGTAGAG GGCGGTGGAG 360 GCTCCCCGGG TGAACCGTCT GGTCCAATCT CTACTATCAA CCCGTCTCCT CCGTCTAAAG 420 O:\92\92747.DOC -51- 200413407 AATCTCATAA ATCTCCAAAC ATGTAAGGTA CCGCATGCAA GCTT 464 (2)序列編號NO: 88資料： (i)序列特性： (A)長度：419鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 88 CCATGGCTAA CTGCTCTATA ATGATCGATG AAATTATACA TCACTTAAAG AGACCACCTG 60 CACCTTTGCT GGACCCGAAC AACCTCAATG ACGAAGACGT CTCTATCCTG ATGGATCGAA 120 ACCTTCGACT TCCAAACCTG GAGAGCITCG TAAGGGCTGT CAAGAACTTA GAAAATGCAT 180 CAGGTATTGA GGCAATTCTT CGTAATCTCC AACCATGTCT GCCCTCTCCC ACGGCCGCAC 240 CCTCTCGACA TCCAATCATC ATCAAGGCAG GTGACTGGCA AGAATTCCGG GAAAAACTGA 300 CGTTCTATCT GGTTACCCTT GAGCAAGCGC AGGAACAACA GTACGTAGAG GGCGGTGGAG 360 GCTCCCCGGG TGGTGGTTCT GGCGGCGGCT CCAACATGTA AGGTACCGCA TGCAAGCTT 419 (2)序列編號NO: 89資料： (i)序列特性： (A)長度：405鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號 NO: 89 GCCACCCAGG ACTGCTCCTT CCAACACAGC CCCATCTCCT CCGACTTCGC TGTCAAAATC 60 CGTGAGCTGT CTGACTACCT GCTTCAAGAT TACCCAGTCA CCGTGGCCTC CAACCTGCAG 120 GACGAGGAGC TCTGCGGGGC GCTCTGGCGG CTGGTCCTGG CACAGCGCTG GATGGAGCGG 180 CTCAAGACTG TCGCTGGGTC CAAGATGCAA GGCTTGCTGG AGCGCGTGAA CACGGAGATA 240 CACTTTGTCA CCAAATGTGC CmCAGCCC CCCCCCAGCT GTCTTCGCTT CGTCCAGACC 300 AACATCTCCC GCCTCCTGCA GGAGACCTCC GAGCAGCTGG TGGCGCTGAA GCCCTGGATC 360 ACTCGCCAGA ACTTCTCCCG GTGCCTGGAG CTGCAGTGTC AGCCC 405 (2)序列編號NO·· 90資料： (i)序列特性： (A) 長度：420鹼基對 (B) 形式：核酸 O:\92\92747.DOC -52- 200413407 (c)股數：單 (D)拓撲結構：線形 (xi)序列描述：序列編號NO: 90 GCCACCCAGG ACTGCTCCTT CCAACACAGC CCCATCTCCT CCGACTTCGC TGTCAAAATC 60 CGTGAGCTGT CTGACTACCT GCTTCAAGAT TACCCAGTCA CCGTGGCCTC CAACCTGCAG 120 GACGAGGAGC TCTGCGGGGG CCTCTGGCGG CTGGTCCTGG CACAGCGCTG GATGGAGCGG 180 CTCAAGACTG TCGCTGGGTC CAAGATGCAA GGCTTGCTGG AGCGCGTGAA CACGGAGATA 240 CACTTTGTCA CCAAATGTGC CTTTCAGCCC CCCCCCAGCT GTCTTCGCTT CGTCCAGACC 300 AACATCTCCC GCCTCCTGCA GGAGACCTCC GAGCAGCTGG TGGCGCTGAA GCCCTGGATC 360 ACTCGCCAGA ACTTCTCCCG GTGCCTGGAG CTGCAGTGTC AGCCCGACTC CTCAACCCTG 420 (2)序列編號NO: 91資料： (〇序列特性： (A)長度：366鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 91 GCCACCCAGG ACTGCTCCTT CCAACACAGC CCCATCTCCT CCGACTTCGC TGTCAAAATC 60 CGTGAGCTGT CTGACTACCT GCTTCAAGAT TACCCAGTCA CCGTGGCCTC CAACCTGCAG 120 GACGAGGAGC TCTGCGGGGG CCTCTGGCGG CTGGTCCTGG CACAGCGCTG GATGGAGCGG 180 CTCAAGACTG TCGCTGGGTC CAAGATGCAA GGCTTGCTGG AGCGCGTGAA CACGGAGATA 240 CACTTTGTCA CCAAATGTGC CTTTCAGGAG ACCTCCGAGC AGCTGGTGGC GCTGAAGCCC 300 TGGATCACTC GCCAGAACTT CTCCCGGTGC CTGGAGCTGC AGTGTCAGCC CGACTCCTCA 360 ACCCTG 366 (2)序列編號NO: 92資料： (i)序列特性： (A)長度：405鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 92 GGAACTCAGG ATTGTTCnr CCAACACAGC CCCATCTCCT CCGACTTCGC TGTCAAAATC 60 CGTGAGCTGT CTGACTACCT GCTTCAAGAT TACCCAGTCA CCGTGGCCTC CAACCTGCAG 120 GACGAGGAGC TCTGCGGGGG CCTCTGGCGG CTGGTCCTGG CACAGCGCTG GATGGAGCGG 180 O:\92\92747.DOC -53- 200413407 CTCAAGACTG TCGCTGGGTC CAAGATGCAA GGCTTGCTGG AGCGCGTGAA CACGGAGATA 240 CACTTTGTCA CCAAATGTGC CTTTCAGCCC CCCCCCAGCT GTCTTCGCTT CGTCCAGACC 300 AACATCTCCC GCCTCCTGCA GGAGACCTCC GAGCAGCTGG TGGCGCTGAA GCCCTGGATC 360 ACTCGCCAGA ACTTCTCCCG GTGCCTGGAG CTGCAGTGTC AGCCC 405 (2)序列編號NO: 93資料： (i)序列特性· (A) 長度：420鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 93 GGTACCCAGG ATTGTTCTTT CCAACACAGC CCCATCTCCT CCGACTTCGC TGTCAAAATC 60 CGTGAGCTGT CTGACTACCT GCTTCAAGAT TACCCAGTCA CCGTGGCCTC CAACCTGCAG 120 GACGAGGAGC TCTGCGGGGG CCTCTGGCGG CTGGTCCTGG CACAGCGCTG GATGGAGCGG 180 CTCAAGACTG TCGCTGGGTC CAAGATGCAA GGCTTGCTGG AGCGCGTGAA CACGGAGATA 240 CACTTTGTCA CCAAATGTGC CTTTCAGCCC CCCCCCAGCT GTCTTCGCTT CGTCCAGACC 300 AACATCTCCC GCCTCCTGCA GGAGACCTCC GAGCAGCTGG TGGCGCTGAA GCCCTGGATC 360 ACTCGCCAGA ACTTCTCCCG GTGCCTGGAG CTGCAGTGTC AGCCCGACTC CTCAACCCTG 420 (2)序列編號NO: 94資料： (i)序列特性： (A) 長度：405鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形〇i)序列描述：序列編號NO: 94 GCCACTCAGG ACTOTTCnT CCAACACAGC CCCATCTCCT CCGACTTCGC TGTCAAAATC 60 CGTGAGCTGT CTGACTACCT GCTTCAAGAT TACCCAGTCA CCGTGGCCTC CAACCTGCAG 120 GACGAGGAGC TCTGCGGGGG CCTCTGGCGG CTGGTCCTGG CACAGCGCTG GATGGAGCGG 180 CTCAAGACTG TCGCTGGGTC CAAGATGCAA GGCTTGCTGG AGCGCGTGAA CACGGAGATA 240 CACTITGTCA CCAAATGTGC CTTTCAGCCC CCCCCCAGCT GTCTTCGCTT CGTCCAGACC 300 AACATCTCCC GCCTCCTGCA GGAGACCTCC GAGCAGCTGG TGGCGCTGAA GCCCTGGATC 360 ACTCGCCAGA ACTTCTCCCG GTGCCTGGAG CTGCAGTGTC AGCCC 405 (2)序列編號NO: 95資料： ⑴序列特性： O:\92\92747.DOC -54- 200413407 (A) 長度：420鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 95 GCCACTCAGG ACTGCTCTTT TCAACACAGC CCCATCTCCT CCGACTTCGC TGTCAAAATC 60 CGTGAGCTGT CTGACTACCT GCTTCAAGAT TACCCAGTCA CCGTGGCCTC CAACCTGCAG 120 GACGAGGAGC TCTGCGGGGG CCTCTGGCGG CTGGTCCTGG CACAGCGCTG GATGGAGCGG 180 CTCAAGACTG TCGCTGGGTC CAAGATGCAA GGCTTGCTGG AGCGCGTGAA CACGGAGATA 240 CACTTTGTCA CCAAATGTGC CTTTCAGCCC CCCCCCAGCT GTCTTCGCTT CGTCCAGACC 300 AACATCTCCC GCCTCCTGCA GGAGACCTCC GAGCAGCTGG TGGCGCTGAn GCCCTGGATC 360 ACTCGCCAGA ACTTCTCCCG GTGCCTGGAG CTGCAGTCTC AGCCCGACTC CTCAACCCTG 420 (2)序列編號NO: 96資料： (i)序列特性： (A)長度：465鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO·. 96 GCCGACGAGG AGCTCTGCGG GGGCCTCTGG CGGCTGGTCC TGGCACAGCG CTGGATGGAG 60 CGGCTCAAGA CTGTCGCTGG GTCCAAGATG CAAGGCTTGC TGGAGCGCGT GAACACGGAG 120 ATACACTTTG TCACCAAATG TGCCTTTCAG CCCCCCCCCA GCTGTCITCG CTTCGTCCAG 180 ACCAACATCT CCCGCCTCCT GCAGGAGACC TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG 240 ATCACTCGCC AGAACTTCTC CCGGTGCCTG GAGCTGCAGT GTCAGCCCGA CTCCTCAACC 300 CTGTCTGGAG GTAACGGATC CGGTGGCAAT GGGAGCGGCG GAAATGGAAC CCAGGACTGC 360 TCCTTCCAAC ACAGCCCCAT CTCCTCCGAC TTCGCTOTCA AAATCCGTGA GCTGTCTGAC 420 TACCTGCTTC AAGATTACCC AGTCACCGTG GCCTCCAACC TGCAG 465 (2)序列編號NO: 97資料： (i)序列特性： (A) 長度：450鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 O:\92\92747.DOC -55- 200413407 (xi)序列描述：序列編號NO: 97 GCCGACGAGG AGCTCTGCGG GGGCCTCTGG CGGCTGGTCC TGGCACAGCG CTGGATGGAG 60 CGGCTCAAGA CTGTCGCTGG GTCCAAGATG CAAGGCTTGC TGGAGCGCGT GAACACGGAG 120 ATACACTTTG TCACCAAATG TGCCTTTCAG CCCCCCCCCA GCTGTCTTCG CTTCGTCCAG 180 ACCAACATCT CCCGCCTCCT GCAGGAGACC TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG 240 ATCACTCGCC AGAACTTCTC CCGGTGCCTG GAGCTGCAGT GTCAGCCCGA CTCCTCAACC 300 CTGTCAGGCG GTAACGGCAG TGGAGGTAAT GGCACCCAGG ACTGCTCCTT CCAACACAGC 360 CCCATCTCCT CCGACTTCGC TGTCAAAATC CGTGAGCTGT CTGACTACCT GCTTCAAGAT 420 TACCCAGTCA CCGTGGCCTC CAACCTGCAG 450 (2)序列編號NO: 98資料： (i)序列特性· (A)長度：435鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 98 GCCGACGAGG AGCTCTGCGG GGGCCTCTGG CGGCTGGTCC TGGCACAGCG CTGGATGGAG 60 CGGCTCAAGA CTGTCGCTGG GTCCAAGATG CAAGGCTTGC TGGAGCGCGT GAACACGGAG 120 ATACACTTTG TCACCAAATG TGCCTTTCAG CCCCCCCCCA GCTGTCTTCG CTTCGTCCAG 180 ACCAACATCT CCCGCCTCCT GCAGGAGACC TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG 240 ATCACTCGCC AGAACTTCTC CCGGTGCCTG GAGCTGCAGT GTCAGCCCGA CTCCTCAACC 300 CTGTCTGGCG GCAACGGCAC CCAGGACTGC TCCTTCCAAC ACAGCCCCAT CTCCTCCGAC 360 TTCGCTGTCA AAATCCGTGA GCTGTCTGAC TACCTGCTTC AAGATTACCC AGTCACCGTG 420 GCCTCCAACC TGCAG 435 (2)序列編號NO: 99資料： (i)序列特性： (A)長度：465鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 99 GCCTCCAAGA TGCAAGGCTT GCTGGAGCGC GTGAACACGG AGATACACTT TGTCACCAAA 60 TGTGCCTTTC AGCCCCCCCC CAGCTGTCIT CGCTTCGTCC AGACCAACAT CTCCCGCCTC 120 CTGCAGGAGA CCTCCGAGCA GCTGGTGGCG CTGAAGCCCT GGATCACTCG CCAGAACTTC 180 TCCCGGTGCC TGGAGCTGCA GTGTCAGCCC GACTCCTCAA CCCTGTCTGG AGGTAACGGA 240 TCCGGTGGCA ATGGGAGCGG CGGAAATGGA ACCCAGGACT GCTCCTTCCA ACACAGCCCC 300 O:\92\92747.DOC -56- 200413407 ATCTCCTCCG ACTTCGCTGT CAAAATCCGT GAGCTGTCTG ACTACCTGCT TCAAGAmC 360 CCAGTCACCG TGGCCTCCAA CCTGCAGGAC GAGGAGCTCT GCGGGGGCCT CTGGCGGCTG 420 GTCCTGGCAC AGCGCTGGAT GGAGCGGCTC AAGACTGTCG CTGGG 465 (2)序列編號NO: 100資料 • (i)序列特性： (A)長度：450鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 100 GCCTCCAAGA TGCAACGCTT GCTGGAGCGC GTGAACACGG AGATACACTT TGTCACCAAA 60 TGTGCCTTTC AGCCCCCCCC CAGCTGTCTT CGCTTCGTCC AGACCAACAT CTCCCGCCTC 120 CTGCAGGAGA CCTCCGAGCA GCTGGTGGCG CTGAAGCCCT GGATCACTCG CCAGAACTTC 180 TCCCGGTGCC TGGACCTGCA GTGTCAGCCC GACTCCTCAA CCCTGTCTGG AGGTAACGGA 240 TCCGGAGGTA ATGGCACCCA GGACTGCTCC TTCCAACACA GCCCCATCTC CTCCGACTTC 300 GCTGTCAAAA TCCGTGAGCT GTCTGACTAC CTGCTTCAAG ATTACCCAGT CACCGTGGCC 360 TCCAACCTGC AGGACGAGGA GCTCTGCGGG GGCCTCTGGC GGCTGGTCCT GGCACAGCGC 420 TGGATGGAGC GGCTCAAGAC TGTCGCTGGG 450 (2)序列編號NO: 101資料 • (i)序列特性： (A)長度：435鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 101 GCCTCCAAGA TGCAAGGCTT GCTGGAGCGC GTGAACACGG AGATACACTT TGTCACCAAA 60 TGTGCCTTTC AGCCCCCCCC CAGCTGTCTT CGCTTCGTCC AGACCAACAT CTCCCGCCTC 120 CTGCAGGAGA CCTCCGAGCA GCTGGTGGCG CTGAAGCCCT GGATCACTCG CCAGAACTTC 180 TCCCGGTGCC TGGAGCTGCA GTGTCAGCCC GACTCCTCAn CCCTGTCTGG CGGCAACGGC 240 ACGCAGGACT GCTCCTTCCA ACACAGCCCC ATCTCCTCCG ACTTCGCTGT CAAAATCCGT 300 GAGCTGTCTG ACTACCTGCT TCAAGATTAC CCAGTCACCG TGGCCTCCAA CCTGCAGGAC 360 GAGGAGCTCT GCGGGGGCCT CTGGCGGCTG GTCCTGGCAC AGCGCTGGAT GGAGCGGCTC 420 AAGACTGTCG CTGGG 435 (2)序列編號NO: 102資料 1 ⑴序列特性： O:\92\92747.DOC -57- 200413407 (A) 長度：465鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 102 GCCCCCCCCA GCTGTCTTCG CTTCGTCCAG ACCAACATCT CCCGCCTCCT GCAGGAGACC 60 TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG ATCACTCGCC AGAACTTCTC CCGGTGCCTG 120 GAGCTGCAGT GTCAGCCCGA CTCCTCAACC CTGTCTGGAG GTAACGGCAG TGGTGGCAAT 180 GGGAGCGGTG GAAATGGAAC CCAGGACTGC TCCTTCCAAC ACAGCCCCAT CTCCTCCGAC 240 TTCGCTGTCA AAATCCGTGA GCTGTCTGAC TACCTGCTTC AAGATTACCC AGTCACCGTG 300 GCCTCCAACC TGCAGGACGA GGAGCTCTGC GGGGGCCTCT GGCGGCTGGT CCTGGCACAG 360 CGCTGGATGG AGCGGCTCAA GACTGTCGCT GGGTCCAAGA TGCAAGGCTT GCTGGAGCGC 420 GTGAACACGG AGATACACTT TGTCACCAAA TGTGCCTTTC AGCCC 465 (2)序列編號NO: 103資料 • (i)序列特性： (A)長度：450鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO·. 103 GCCCCCCCCA GCTGTCTTCG CTTCGTCCAG ACCAACATCT CCCGCCTCCT GCAGGAGACC 60 TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG ATCACTCGCC AGAACTTCTC CCGGTGCCTG 120 GAGCTGCAGT GTCAGCCCGA CTCCTCAACC CTGTCAGGCG GTAACGGCAG TGGAGGTAAT 180 GGCACCCAGG ACTGCTCCTT CCAACACAGC CCCATCTCCT CCGACTTCGC TGTCAAAATC 240 CGTGAGCTGT CTGACTACCT GCTTCAAGAT TACCCAGTCA CCGTGGCCTC CAACCTGCAG 300 GACGAGGAGC TCTGCGGGGG CCTCTGGCGG CTGGTCCTGG CACAGCGCTG GATGGAGCGG 360 CTCAAGACTG TCGCTGGGTC CAAGATGCAA GGCTTGCTGG AGCGCGTGAA CACGGAGATA 420 CACTTTGTCA CCAAATGTGC CTTTCAGCCC 450 (2)序列編號NO: 104資料 : (i)序列特性： (A) 長度：435鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 O:\92\92747.DOC -58- 200413407 (xi)序列描述：序列編號NO: 104 GCCCCCCCCA GCTGTCITCG CTTCGTCCAG ACCAACATCT CCCGCCTCCT GCAGGAGACC 60 TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG ATCACTCGCC AGAACTTCTC CCGGTGCCTG 120 GAGCTGCAGT GTCAGCCCGA CTCCTCAACC CTGTCTGGCG GCAACGGCAC GCAGGACTGC 180 TCCTTCCAAC ACAGCCCCAT CTCCTCCGAC TTCGCTGTCA AAATCCGTGA GCTGTCTGAC 240 TACCTGCTTC AAGAmCCC AGTCACCGTG GCCTCCAACC TGCAGGACGA GGAGCTCTGC 300 GGGGGCCTCT GGCGGCTGGT CCTGGCACAG CGCTGGATGG AGCGGCTCAA GACTGTCGCT 360 GGGTCCAAGA TGCAAGGCTT GCTGGAGCGC GTGAACACGG AGATACACTT TGTCACCAAA 420 TGTGCCTTTC AGCCC 435 (2)序列編號NO: 105資料 ·· (i)序列特性： (A)長度：451鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 105 GCCGACGAGG AGCTCTGCGG GGGCCTCTGG CGGCTGGTCC TGGCACAGCG CTGGATGGAG 60 CGGCTCAAGA CTGTCGCTGG GTCCAAGATG CAAGGCTTGC TGGAGCGCGT GAACACGGAG 120 ATACACTTTG TCACCAAATG TGCCTTTCAG CCCCCCCCCA GCTGTCTTCG CTTCGTCCAG 180 ACCAACATCT CCCGCCTCCT GCAGGAGACC TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG 240 ATCACTCGCC AGAACTTCTC CCGGTGCCTG GAGCTGCAGT GTCAGCCCGA CTCCTCAACC 300 CTGTCTGGAG GTAGTGGATC CGGAGGTTCT GGCAACCCAG GACTGCTCCT TCCAACACAG 360 CCCCATCTCC TCCGACTTCG CTGTCAAAAT CCGTGAGCTG TCTGACTACC TGCITCAAGA 420 TTACCCAGTC ACCGTGGCCT CCAACCTGCA G 451 (2)序列編號NO: 106資料 • (i)序列特性： (A)長度：465鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO.· 106 GCCGACGAGG AGCTCTGCGG GGGCCTCTGG CGGCTGGTCC TGGCACAGCG CTGGATGGAG 60 CGGCTCAAGA CTGTCGCTGG GTCCAAGATG CAAGGCTTGC TGGAGCGCGT GAACACGGAG 120 ATACACITTG TCACCAAATG TGCCTTTCAG CCCCCCCCCA GCTGTCTTCG CTTCGTCCAG 180 ACCAACATCT CCCGCCTCCT GCAGGAGACC TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG 240 ATCACTCGCC AGAACTTCTC CCGGTGCCTG GAGCTGCAGT GTCAGCCCGA CTCCTCAACC 300 O:\92\92747.DOC -59- 200413407 CTGTCTGGAG GTAGTGGATC CGGTGGCAGT GGGAGCGGCG GATCTGGAAC CCAGGACTGC 360 TCCTTCCAAC ACAGCCCCAT CTCCTCCGAC TTCGCTGTCA AAATCCGTGA GCTGTCTGAC 420 TACCTGCTTC AAGATTACCC AGTCACCGTG GCCTCCAACC TGCAG 465 (2)序列編號NO: 107資料 : (i)序列特性： (A)長度：437鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 107 CCATGGCCAC CCAGGACTGC TCCTTCCAAC ACAGCCCCAT CTCCTCCGAC TTCGCTGTCA 60 AAATCCGTGA GCTGTCTGAC TACCTGCTTC AAGATTACCC AGTCACCGTG GCCTCCAACC 120 TGCAGGACGA GGAGCTCTGC GGGGGCCTCT GGCGGCTGGT CCTGGCACAG CGCTGGATGG 180 AGCGGCTCAA GACTGTCGCT GGGTCCAAGA TGCAAGGCTT GCTGGAGCGC GTGAACACGG 240 AGATACACTT TGTCACCAAA TGTGCCTTTC AGCCCCCCCC CAGCTGTCTT CGCTTCGTCC 300 AGACCAACAT CTCCCGCCTC CTGCAGGAGA CCTCCGAGCA GCTGGTGGCG CTGAAGCCCT 360 GGATCACTCG CCAGAACTTC TCCCGGTGCC TGGAGCTGCA GTGTCAGCCC GACTCCTCAA 420 CCCTGGGCGG TGGATCC 437 (2)序列編號NO: 108資料 : (i)序列特性： (A)長度：436鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 ⑽序列描述：序列編號NO: 108 GGATCCGGAG GTACCCAGGA CTGCTCCITC CAACACAGCC CCATCTCCTC CGACTTCGCT 60 GTCAAAATCC GTGAGCTGTC TGACTACCTG cnckkGm ACCCAGTCAC CGTGGCCTCC 120 AACCTGCAGG ACGAGGAGCT CTGCGGGGGC CTCTGGCGGC TGGTCCTGGC ACAGCGCTGG 180 ATGGAGCGGC TCAAGACTGT CGCTGGGTCC AAGATGCAAG GCTTGCTGGA GCGCGTGAAC 240 ACGGAGATAC ACTTTGTCAC CAAATGTGCC TTTCAGCCCC CCCCCAGCTG TCTTCGCTTC 300 GTCCAGACCA ACATCTCCCG CCTCCTGCAG GAGACCTCCG AGCAGCTGGT GGCGCTGAAG 360 CCCTGGATCA CTCGCCAGAA CTTCTCCCGG TGCCTGGAGC TGCAGTGTCA GCCCGACTCC 420 TCAACCCTGT AAGCTT 436 (2)序列編號NO: 109資料

⑴序列特性： O:\92\92747.DOC -60- 200413407 (A) 長度：449鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 109 CCATGGCCAC CCAGGACTGC TCCTTCCAAC ACAGCCCCAT CTCCTCCGAC TTCGCTGTCA 60 AAATCCGTGA GCTGTCTGAC TACCTGCTTC AAGATTACCC AGTCACCGTG GCCTCCAACC 120 TGCAGGACGA GGAGCTCTGC GGGGGCCTCT GGCGGCTGGT CCTGGCACAG CGCTGGATGG 180 AGCGGCTCAA GACTGTCGCT GGGTCCAAGA TGCAAGGCTT GCTGGAGCGC GTGAACACGG 240 AGATACACTT TGTCACCAAA TGTGCCTTTC AGCCCCCCCC CAGCTGTCIT CGCTTCGTCC 300 AGACCAACAT CTCCCGCCTC CTGCAGGAGA CCTCCGAGCA GCTGGTGGCG CTGAAGCCCT 360 GGATCACTCG CCAGAACTTC TCCCGGTGCC TGGAGCTGCA GTGTCAGCCC GACTCCTCAA 420 CCCTGGGCGG TGGGTCAGGA GGTGGATCC 449 (2)序列編號NO.· 110資料 • (i)序列特性： (A)長度：439鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 110 GGATCCGGAG GTGGCACCCA GGACTGCTCC TTCCAACACA GCCCCATCTC CTCCGACTTC 60 GCTGTCAAAA TCCGTGAGCT GTCTGACTAC CTGCTTCAAG ATTACCCAGT CACCGTGGCC 120 TCCAACCTGC AGGACGAGGA GCTCTGCGGG GGCCTCTGGC GGCTGGTCCT GGCACAGCGC 180 TGGATGGAGC GGCTCAAGAC TGTCGCTGGG TCCAAGATGC AAGGCTTGCT GGAGCGCGTG 240 AACACGGAGA TACACTTTGT CACCAAATGT GCCTTTCAGC CCCCCCCCAG CTGTCTTCGC 300 TTCGTCCAGA CCAACATCTC CCGCCTCCTG CAGGAGACCT CCGAGCAGCT GGTGGCGCTG 360 AAGCCCTGGA TCACTCGCCA GAACTTCTCC CGGTGCCTGG AGCTGCAGTG TCAGCCCGAC 420 TCCTCAACCC TGTAAGCTT 439 (2)序列編號NO: 111資料 • ⑴序列特性： (A) 長度：461鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 O:\92\92747.DOC -61- 200413407 (xi)序列描述：序列編號 NO: 111 CCATGGCCAC CCAGGACTGC TCCTTCCAAC ACAGCCCCAT CTCCTCCGAC TTCGCTGTCA 60 AAATCCGTGA GCTGTCTGAC TACCTGCTTC MGATTACCC AGTCACCGTG GCCTCCAACC 120 TGCAGGACGA GGAGCTCTGC GGGGGCCTCT GGCGGCTGGT CCTGGCACAG CGCTGGATGG 180 AGCGGCTCAA GACTGTCGCT GGGTCCAAGA TGCAAGGCTT GCTGGAGCGC GTGAACACGG 240 AGATACACTT TGTCACCAAA TGTGCCTTTC AGCCCCCCCC CAGCTGTCrT CGCTTCGTCC 300 AGACCAACAT CTCCCGCCTC CTGCAGGAGA CCTCCGAGCA GCTGGTGGCG CTGAAGCCCT 360 GGATCACTCG CCAGAACTTC TCCCGGTGCC TGGAGCTGCA GTGTCAGCCC GACTCCTCAA 420 CCCTGGGCGG TGGGTCAGGA GGTGGGTCAG GAGGTGGATC C 461 (2)序列編號NO: 112資料： ⑴序列特性： (A) 長度：457鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 112 GGATCCGGAG GTGGCTCAGG GGGAGGTAGT GGTACCCAGG ACTGCTCCTT CCAACACAGC 60 CCCATCTCCT CCGACTTCGC TGTCAAAATC CGTGAGCTGT CTGACTACCT GCTTCAAGAT 120 TACCCAGTCA CCGTGGCCTC CAACCTGCAG CACGAGGAGC TCTGCGGGGG CCTCTGGCGG 180 CTGGTCCTGG CACAGCGCTG GATGGAGCGG CTCAAGACTG TCGCTGGGTC CAAGATGCAA 240 GGCTTGCTGG AGCGCGTGAA CACGGAGATA CACITTGTCA CCAAATGTGC CTTTCAGCCC 300 CCCCCCAGCT GTCTTCGOT CGTCCAGACC AACATCTCCC GCCTCCTGCA GGAGACCTCC 360 GAGCAGCTGG TGGCGCTGAA GCCCTGGATC ACTCGCCAGA ACTTCTCCCG GTGCCTGGAG 420 CTGCAGTGTC AGCCCGACTC CTCAACCCTG TAAGCTT 457 (2)序列編號NO: 113資料 • ⑴序列特性： (A) 長度：438鹼基對 (B) 形式：核酸 (C) 股數：單 :線形序列編號NO: 113 (D) 拓撲結構 (xi)序列描述： GCCGACGAGG AGCTCTGCGG GGGCCTCTGG CGGCTGGTCC TGGCACAGCG CTGGATGGAG 60 CGGCTCAAGA CTGTCGCTGG GTCCAAGATG CAAGGC7TGC TGGAGCGCGT GAACACGGAG 120 ATACACTTTG TCACCAAATG TGCCTTTCAG CCCCCCCCCA GCTGTdTCG CTTCGTCCAG 180 ACCAACATCT CCCGCCTCCT GCAGGAGACC TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG 240 ATCACTCGCC AGAACTTCTC CCGGTGCCTG GAGCTGCAGT GTCAGCCCGA CTCCTCAACC 300 O:\92\92747.DOC -62- 200413407 CTGGGCGGTG GATCCGGAGG TACCCAGGAC TGCTCCTTCC AACACAGCCC CATCTCCTCC 360 GACTTCGCTG TCAAAATCCG TGAGCTGTCT GACTACCTGC TTCAAGATTA CCCAGTCACC 420 GTGGCCTCCA ACCTGCAG 438 (2)序列編號NO·· 114資料 • (i)序列特性： (A)長度：441鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO·. 114 GCCGACGAGG AGCTCTGCGG GGGCCTCTCXj CGGCTGGTCC TGGCACAGCG CTGGATGGAG 60 CGGCTCAAGA CTGTCGCTGG GTCCAAGATG CAAGGCTTGC TGGAGCGCGT GAACACGGAG 120 ATACACTTTG TCACCAAATG TGCCTTTCAG CCCCCCCCCA GCTGTCTTCG CTTCGTCCAG 180 ACCAACATCT CCCGCCTCCT GCAGGAGACC TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG 240 ATCACTCGCC AGAACTTCTC CCGGTGCCTG GAGCTGCAGT GTCAGCCCGA CTCCTCAACC 300 CTGGGCGGTG GATCCGGAGG TGGCACCCAG GACTGCTCCT TCCAACACAG CCCCATCTCC 360 TCCGACTTCG CTGTCAAAAT CCGTGAGCTG TCTGACTACC TGCTTCAAGA TTACCCAGTC 420 ACCGTGGCCT CCAACCTGCA G 441 (2)序列編號NO: 115資料 ·· (i)序列特性： (A)長度：450鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 115 GCCGACGAGG AGCTCTGCGG GGGCCTCTGG CGGCTGGTCC TGGCACAGCG CTGGATGGAG 60 CGGCTCAAGA CTGTCGCTGG GTCCAAGATG CAAGGCTTGC TGGAGCGCGT GAACACGGAG 120 ATACACTTTG TCACCAAATG TGCCTTTCAG CCCCCCCCCA GCTGTCTTCG CTTCGTCCAG 180 ACCAACATCT CCCGCCTCCT GCAGGAGACC TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG 240 ATCACTCGCC AGAACTTCTC CCGGTGCCTG GAGCTGCAGT GTCAGCCCGA CTCCTCAACC 300 CTGGGCGGTG GGTCAGGAGG TGGATCCGGA GGTACCCAGG ACTGCTCCTT CCAACACAGC 360 CCCATCTCCT CCGACTTCGC TGTCAAAATC CGTGAGCTGT CTGACTACCT GCTTCAAGAT 420 TACCCAGTCA CCGTGGCCTC CAACCTGCAG 450 (2)序列編號NO: 116資料 * ⑴序列特性： O:\92\92747.DOC -63- 200413407 (A) 長度：459鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 116 GCCGACGAGG AGCTCTGCGG GGGCCTCTGG CGGCTGGTCC TGGCACAGCG CTGGATGGAG 60 CGGCTCAAGA CTGTCGCTGG GTCCAAGATG CAAGGCTTGC TGGAGCGCGT GAACACGGAG 120 ATACACITTG TCACCAAATG TGCCTTTCAG CCCCCCCCCA GCTGTCTTCG CTTCGTCCAG 180 ACCAACATCT CCCGCCTCCT GCAGGAGACC TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG 240 ATCACTCGCC AGAACTTCTC CCGGTGCCTG GAGCTGCAGT GTCAGCCCGA CTCCTCAACC 300 CTGGGCGGTG GATCCGGAGG TGGCTCAGGG GGAGGTAGTG GTACCCAGGA CTGCTCCITC 360 CAACACAGCC CCATCTCCTC CGACTTCGCT GTCAAAATCC GTGAGCTGTC TGACTACCTG 420 CTTCAAGATT ACCCAGTCAC CGTGGCCTCC AACCTGCAG 459 (2)序列編號NO: 117資料 • (i)序列特性： (A)長度：465鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 117 GCCGACGAGG AGCTCTGCGG GGGCCTCTGG CGGCTGGTCC TGGCACAGCG CTGGATGGAG 60 CGGCTCAAGA CTGTCGCTGG GTCCAAGATG CAAGGCTTGC TGGAGCGCGT GAACACGGAG 120 ATACACTTTG TCACCAAATG TGCCTTTCAG CCCCCCCCCA GCTGTCTTCG CTTCGTCCAG 180 ACCAACATCT CCCGCCTCCT GCAGGAGACC TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG 240 ATCACTCGCC AGAACTTCTC CCGGTGCCTG GAGCTGCAGT GTCAGCCCGA CTCCTCAACC 300 CTGGGCGGTG GGTCAGGAGG TGGGTCAGGA GGTGGATCCG GAGGTGGCAC CCAGGACTGC 360 TCCTTCCAAC ACAGCCCCAT CTCCTCCGAC TTCGCTGTCA AAATCCGTGA GCTGTCTGAC 420 TACCTGCTTC AAGATTACCC AGTCACCGTG GCCTCCAACC TGCAG 465 (2)序列編號NO·· 118資料 * ⑴序列特性： (A) 長度：483鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 O:\92\92747.DOC -64- 200413407 (xi)序列描述：序列編號NO: 118

GCCGACGAGG AGCTCTGCGG GGGCCTCTGG CGGCTGGTCC TGGCACAGCG CTGGATGGAG 60 CGGCTCAAGA CTGTCGCTGG GTCCAAGATG CAAGGCTTGC TGGAGCGCGT GAACACGGAG 120 ATACACTTTG TCACCAAATG TGCCTTTCAG CCCCCCCCCA GCTGCCITCG CTTCGTCCAG 180 ACCAACATCT CCCGCCTCCT GCAGGAGACC TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG 240 ATCACTCGCC AGAACTTCTC CCGGTGCCTG GAGCTGCAGT GTCAGCCCGA CTCCTCAACC 300 CTGGGCGGTG GGTCAGGAGG TGGGTCAGGA GGTGGATCCG GAGGTGGCTC AGGGGGAGGT 360 AGTGGTACCC AGGACTGCTC CTTCCAACAC AGCCCCATCT CCTCCGACTT CGCTGTCAAA 420 ATCCGTGAGC TGTCTGACTA CCTGCTTCAA GAmCCCAG TCACCGTGGC CTCCAACCTG 480 CAG 483 (2)序列編號NO: 119資料 ·· (i)序列特性： (A)長度：843鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 119 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTGCACCT 60 TTGCTGGACC CGAACAACCT CAATGACGAA GACGTCTCTA TCCTGATGGA CCGAAACCTT 120 CGACTTCCAA ACCTGGAGAG CTTCGTAAGG GCTGTCAAGA ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCITGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CACCCAGGAC TGCTCCTTCC AACACAGCCC CATCTCCTCC 480 GACTTCGCTG TCAAAATCCG TGAGCTGTCT GACTACCTGC TTCAAGATTA CCCAGTCACC 540 GTGGCCTCCA ACCTGCAGGA CGAGGAGCTC TGCGGGGCGC TCTGGCGGCT GGTCCTGGCA 600 CAGCGCTGGA TGGAGCGGCT CAAGACTGTC GCTGGGTCCA AGATGCAAGG CTTGCTGGAG 660 CGCGTGAACA CGGAGATACA CTTTGTCACC AAATGTGCCT TTCAGCCCCC CCCCAGCTGT 720 CTTCGCTTCG TCCAGACCAA CATCTCCCGC CTCCTGCAGG AGACCTCCGA GCAGCTGGTG 780 GCGCTGAAGC CCTGGATCAC TCGCCAGAAC TTCTCCCGGT GCCTGGAGCT GCAGTGTCAG 840 CCC 843 (2)序列編號NO: 120資料 I ⑴序列特性： (A) 長度：858鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 O:\92\92747.DOC 65- 200413407 (xi)序列描述：序列編號NO: 120 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTGCACCT 60 TTGCTGGACC CGAACAACCT CAATGACGAA GACGTCTCTA TCCTGATGGA CCGAAACCTT 120 CGACTTCCAA ACCTGGAGAG CTTCGTAAGG GCTGTCAAGA ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CACCCAGGAC TGCTCCTTCC AACACAGCCC CATCTCCTCC 480 GACTTCGCTG TCAAAATCCG TGAGCTGTCT GACTACCTGC TTCAAGATTA CCCAGTCACC 540 GTGGCCTCCA ACCTGCAGGA CGAGGAGCTC TGCGGGGCGC TCTGGCGGCT GGTCCTGGCA 600 CAGCGCTGGA TGGAGCGGCT CAAGACTGTC GCTGGGTCCA AGATGCAAGG CTTGCTGGAG 660 CGCGTGAACA CGGAGATACA CTTTGTCACC AAATGTGCCT TTCAGCCCCC CCCCAGCTGT 720 CTTCGCTTCG TCCAGACCAA CATCTCCCGC CTCCTGCAGG AGACCTCCGA GCAGCTGGTG 780 GCGCTGAAGC cCTGGATCAC TCGCCAGAAC TTCTCCCGGT GCCTGGAGCT GCAGTGTCAG 840 CCCGACTCCT CAACCCTG 858 (2)序列編號NO: 121資料： (i)序列特性· (A) 長度：888鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 121 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTGCACCT 60 HGCTGGACC CGAACAACCT CAATGACGAA GACGTCTCTA TCCTGATGGA CCGAAACCTT 120 CGACTTCCAA ACCTGGAGAG CTTCGTAAGG GCTGTCAAGA ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CGACGAGGAG CTCTGCGGGG GCCTCTGGCG GCTGGTCCTG 480 GCACAGCGCT GGATGGAGCG GCTCAAGACT GTCGCTGGGT CCAAGATGCA AGGCTTGCTG 540 GAGCGCGTGA ACACGGAGAT ACACTTTGTC ACCAAATGTG CCHTCAGCC CCCCCCCAGC 600 TGTCTTCGCT TCGTCCAGAC CAACATCTCC CGCCTCCTGC AGGAGACCTC CGAGCAGCTG 660 GTGGCGCTGA AGCCCTGGAT CACTCGCCAG AACTTCTCCC GGTGCCTGGA GCTGCAGTGT 720 CAGCCCGACT CCTCAACCCT GTCAGGCGGT AACGGCAGTG GAGGTAATGG CACCCAGGAC 780 TGCTCCTTCC AACACAGCCC CATCTCCTCC GACTTCGCTG TCAAAATCCG TGAGCTGTCT 840 GACTACCTGC TTCAAGATTA CCCAGTCACC GTGGCCTCCA ACCTGCAG 888 (2 )序列編號N 0: 122資料 • (i)序列特性· (A)長度：903鹼基對 O:\92\92747.DOC -66 200413407 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 122

GCTAACTGCT CTATAATGAT CGATGAAATT mCTGGkCC CGAACAACCT CAATGACGAA CGACTTCCAA ACCTGGAGAG CTTCGTAAGG ATTGAGGCAA πΟΤΟΟΤΑΑ TCTCCAACCA CGACATCCAA TCATCATCAA GGCAGGTGAC TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CCGGGTGAAC CGTCTGGTCC AATCTCTACT CATAAATCTC CAAACATGGC CGACGAGGAG GCACAGCGCT GGATGGAGCG GCTCAAGACT GAGCGCGTGA ACACGGAGAT ACACTTTGTC TGTCTTCGCT TCGTCCAGAC CAACATCTCC GTGGCGCTGA AGCCCTGGAT CACTCGCCAG CAGCCCGACT CCTCAACCCT GTCTGGAGGT AATGGAACCC AGGACTGCTC CTTCCAACAC ATCCGTGAGC TGTCTGACTA CCTGCTTCAA CAG ATACATCACT TAAAGAGACC ACCTGCACCT 60 GACGTCTCTA TCCTGATGGA CCGAAACCTT 120 GCTGTCAAGA ACTTAGAAAA TGCATCAGGT 180 TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CTCTGCGGGG GCCTCTGGCG GCTGGTCCTG 480 GTCGCTGGGT CCAAGATGCA AGGCTTGCTG 540 ACCAAATGTG CCTTTCAGCC CCCCCCCAGC 600 CGCCTCCTGC AGGAGACCTC CGAGCAGCTG 660 AACTTCTCCC GGTGCCTGGA GCTGCAGTGT 720 AACGGATCCG GTGGCAATGG GAGCGGCGGA 780 AGCCCCATCT CCTCCGACTT CGCTGTCAAA 840 GATTACCCAG TCACCGTGGC CTCCAACCTG 900 903 (2)序列編號NO: 123資料 (i)序列特性： (A) 長度：873鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 123 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTGCACCT 60 TTGCTGGACC CGAACAACCT CAATGACGAA GACGTCTCTA TCCTGATGGA CCGAAACCTT 120 CGACTTCCAA ACCTGGAGAG CTTCGTAAGG GCTGTCAAGA ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CTCCAAGATG CAAGGCTTGC TGGAGCGCGT GAACACGGAG 480 ATACACTTTG TCACCAAATG TGCCTTTCAG CCCCCCCCCA GCTGTCTTCG CTTCGTCCAG 540 ACCAACATCT CCCGCCTCCT GCAGGAGACC TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG 600 ATCACTCGCC AGAACTTCTC CCGGTGCCTG GAGCTGCAGT GTCAGCCCGA CTCCTCAACC 660 CTGTCTGGCG GCAACGGCAC GCAGGACTGC TCCITCCAAC ACAGCCCCAT CTCCTCCGAC 720 TTCGCTGTCA AAATCCGTGA GCTGTCTGAC TACCTGCTTC AAGAmCCC AGTCACCGTG 780 GCCTCCAACC TGCAGGACGA GGAGCTCTGC GGGGGCCTCT GGCGGCTGGT CCTGGCACAG 840 CGCTGGATGG AGCGGCTCAA GACTGTCGCT GGG 873 O:\92\92747.DOC -67- 200413407 (2)序列編號NO: 124資料： (i)序列特性： (A) 長度：888鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 124 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTGCACCT 60 TTGCTGGACC CGAACAACCT CAATGACGAA GACGTCTCTA TCCTGATGGA CCGAAACCTT 120 CGACTTCCAA ACCTGGAGAG CTTCGTAAGG GCTGTCAAGA ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGC5GAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CTCCAAGATG CAAGGCTTGC TGGAGCGCGT GAACACGGAG 480 ATACACTTTG TCACCAAATG TGCCTTTCAG CCCCCCCCCA GCTGTCTTCG CTTCGTCCAG 540 ACCAACATCT CCCGCCTCCT GCAGGAGACC TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG 600 ATCACTCGCC AGAACTTCTC CCGGTGCCTG GAGCTGCAGT GTCAGCCCGA CTCCTCAACC 660 CTGTCTGGAG GTAACGGATC CGGAGGTAAT CGCACCCAGG ACTGCTCCTT CCAACACAGC 720 CCCATCTCCT CCGACTTCGC TGTCAAAATC CGTGAGCTGT CTGACTACCT GCTTCAAGAT 780 TACCCAGTCA CCGTGGCCTC CAACCTGCAG GACGAGGAGC TCTGCGGC3GG CCTCTGGCGG 840 CTGGTCCTGG CACAGCGCTG GATGGAGCGG CTCAAGACTG TCGCTGGG 888 (2)序列編號NO: 125資料 (i)序列特性： (A)長度：903鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 125 GCTAACTGCT CTATAATGAT CGATGAAm ATACATCACT TAAAGAGACC ACCTGCACCT 60 TTGCTGGACC CGAACAACCT CAATGACGAA GACGTCTCTA TCCTGATGGA CCGAAACCTT 120 CGACTTCCAA ACCTGGAGAG CTTCGTAAGG GCTGTCAAGA ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CTCCAAGATG CAAGGCTTGC TGGAGCGCGT GAACACGGAG 480 ATACACTTTG TCACCAAATG TGCCTTTCAG CCCCCCCCCA GCTGTCTTCG CTTCGTCCAG 540 O:\92\92747.DOC -68- 200413407

ACCAACATCT CCCGCCTCCT ATCACTCGCC AGAACTTCTC CTGTCTGGAG GTAACGGATC TCCTTCCAAC ACAGCCCCAT TACCTGCTTC AAGAmCCC GGGGGCCTCT GGCGCCTGCT GGG

GCAGGAGACC TCCGAGCAGC CCGGTGCCTG GAGCTGCAGT CGGTGGCAAT GGGAGCGGCG CTCCTCCGAC TTCGCTGTCA AGTCACCGTG GCCTCCAACC cCTGGCACAG CGCTGGATGG TGGTGGCGCT GAAGCCCTGG 600 GTCAGCCCGA CTCCTCAACC 660 GAAATGGAAC CCAGGACTGC 720 AAATCCGTGA GCTGTCTGAC 780 TGCAGGACGA GGAGCTCTGC 840 AGCGGCTCAA GACTGTCGCT 900 903 (2 )序列編號NO: 126資料： (i)序列特性： (A) 長度：873鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 126 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTGCACCT 60 TTGCTGGACC CGAACAACCT CAATGACGAA GACGTCTCTA TCCTGATGGA CCGAAACCTT 120 CGACTTCCAA ACCTGGAGAG CITCGTAAGG GCTGTCAAGA ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGm CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CCCCCCCAGC TGTCTTCGCT TCGTCCAGAC CAACATCTCC 480 CGCCTCCTGC AGGAGACCTC CGAGCAGCTG GTGGCGCTGA AGCCCTGGAT CACTCGCCAG 540 AACTTCTCCC GGTGCCTGGA GCTGCAGTGT CAGCCCGACT CCTCAACCCT GTCTGGCGGC 600 AACGGCACCC AGGACTGCTC CTTCCAACAC AGCCCCATCT CCTCCGACTT CGCTGTCAAA 660 ATCCGTGAGC TGTCTGACTA CCTGCTTCAA GATTACCCAG TCACCGTGGC CTCCAACCTG 720 CAGGACGAGG AGCTCTGCGG GGGCCTCTGG CGGCTGGTCC TGGCACAGCG CTGGATGGAG 780 CGGCTCAAGA CTGTCGCTGG GTCCAAGATG CAAGGCTTGC TGGAGCGCGT GAACACGGAG 840 ATACACTTTG TCACCAAATG TGCCTTTCAG CCC 873 (2)序列編號NO: 127資料： (i)序列特性： (A) 長度：888鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO·. 127 GCTMCTGCT CTATMTGAT CGATGAMTT ATACATCACT TAAAGAGACC ACCTGCACCT 60 TTGCTGGACC CGAACAACCT CAATGACGAA GACGTCTCTA TCCTGATGGA CCGAAACCTT 120 O:\92\92747.DOC •69- 200413407 CGACTTCCAA ACCTGGAGAG CTTCGTAAGG GCTGTCAAGA ACITAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CCCCCCCAGC TGTCTTCGCT TCGTCCAGAC CAACATCTCC 480 CGCCTCCTGC AGGAGACCTC CGAGCAGCTG GTGGCGCTGA AGCCCTGGAT CACTCGCCAG 540 AACTTCTCCC GGTGCCTGGA GCTGCAGTGT CAGCCCGACT CCTCAACCCT GTCAGGCGGT 600 AACGGCAGTG GAGGTAATGG CACCCAGGAC TGCTCCTTCC AACACAGCCC CATCTCCTCC 660 GACTTCGCTG TCAAAATCCG TGAGCTGTCT GACTACCTGC TTCMGAm CCCAGTCACC 720 GTGGCCTCCA ACCtGCAGGA CGAGGAGCTC TGCGGGGGCC TCTGGCGGCT GGTCCTGGCA 780 CAGCGCTGGA TGGAGCGGCT CAAGACTGTC GCTGGGTCCA AGATGCAAGG CTTGCTGGAG 840 CGCGTGAACA CGGAGATACA CTTTGTCACC AAATGTGCCT TTCAGCCC 888 (2)序列編號NO: 128資料 ⑴序列特性： (A) 長度：903鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 128 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTGCACCT 60 TTGCTGGACC CGAACAACCT CAATGACGAA GACGTCTCTA TCCTGATGGA CCGAAACCTT 120 CGACTTCCAA ACCTGGAGAG CTTCGTAAGG GCTGTCAAGA ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA nCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CCCCCCCAGC TGTCTTCGCT TCGTCCAGAC CAACATCTCC 480 CGCCTCCTGC AGGAGACCTC CGAGCAGCTG GTGGCGCTGA AGCCCTGGAT CACTCGCCAG 540 AACTTCTCCC GGTGCCTGGA GCTGCAGTGT CAGCCCGACT CCTCAACCCT GTCTGGAGGT 600 AACGGCAGTG GTGGTAATGG GAGCGGCGGA AATGGAACCC AGGACTGCTC CTTCCAACAC 660 AGCCCCATCT CCTCCGACTT CGCTGTCAAA ATCCGTGAGC TGTCTGACTA CCTGCTTCAA 720 GAmCCCAG TCACCGTGGC CTCCAACCTG CAGGACGAGG AGCTCTGCGG GGGCCTCTGG 780 CGGCTGGTCC TGGCACAGCG CTGGATGGAG CGGCTCAAGA CTGTCGCTGG GTCCAAGATG 840 CAAGGCTTGC TCGAGCGCGT GAACACGGAG ATACACTTTG TCACCAAATG TGCCTTTCAG 900 CCC 903 (2)序列編號NO·· 129資料： ⑴序列特性： (A) 長度：843鹼基對 (B) 形式：核酸 (C) 股數：單 O:\92\92747.DOC -70- 200413407 (D)拓撲結構：線形 (xi)序列描述：序列編號NO: 129 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CAATTCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC GACTCAGGAC TGTTCnTCC AACACAGCCC CATCTCCTCC 480 GACTTCGCTG TCAAAATCCG TGAGCTGTCT GACTACCTGC TTCMGATTA CCCAGTCACC 540 GTGGCCTCCA ACCTGCAGGA CGAGGAGCTC TGCGGGGGCC TCTGGCGGCT GGTCCTGGCA 600 CAGCGCTGGA TGGAGCGGCT CAAGACTGTC GCTGGGTCCA AGATGCAAGG CTTGCTGGAG 660 CGCGTGAACA CGGAGATACA CTTTGTCACC AAATGTGCCT TTCAGCCCCC CCCCAGCTGT 720 CTTCGCTTCG TCCAGACCAA CATCTCCCGC CTCCTGCAGG AGACCTCCGA GCAGCTGGTG 780 GCGCTGAAGC CCTGGATCAC TCGCCAGAAC TTCTCCCGGT GCCTGGAGCT GCAGTGTCAG 840 CCC 843 (2)序列編號NO._ 130資料： (i)序列特性： (A) 長度：858鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 130 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGkCC CGAACAACCT CAATTCTGAA GACATGCATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC AACCCAGGAC TGCTCTTTTC AACACAGCCC CATCTCCTCC 480 GACTTCGCTG TCAAAATCCG TGAGCTGTCT GACTACCTGC TTCMGATTA CCCAGTCACC 540 GTGGCCTCCA ACCTGCAGGA CGAGGAGCTC TGCGGGGGCC TCTGGCGGCT GGTCCTGGCA 600 CAGCGCTGGA TGGAGCGGCT CAAGACTGTC GCTGGGTCCA AGATGCAAGG CTTGCTGGAG 660 CGCGTGAACA CGGAGATACA CTTTGTCACC AAATGTGCCT TTCAGCCCCC CCCCAGCTGT 720 CTTCGCTTCG TCCAGACCAA CATCTCCCGC CTCCTGCAGG AGACCTCCGA GCAGCTGGTG 780 GCGCTGAAGC CCTGGATCAC TCGCCAGAAC TTCTCCCGGT GCCTGGAGCT GCAGTGTCAG 840 CCCGACTCCT CAACCCTG 858 (2)序列編號NO: 131資料： (i)序列特性： O:\92\92747.DOC -71- 200413407 (A) 長度：843鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO.· 131 GCCACTCAGG ACTGCTCCTT CCAACACAGC CCCATCTCCT CCGACTTCGC TGTCAAAATC 60 CGTGAGCTGT CTGACTACCT GCTTCAAGAT TACCCAGTCA CCGTGGCCTC CAACCTGCAG 120 GACGAGGAGC TCTGCGGGGG CCTCTGGCGG CTGGTCCTGG CACAGCGCTG GATGGAGCGG 180 CTCAAGACTG TCGCTGGGTC CAAGATGCAA GGCTTGCTGG AGCGCGTGAA CACGGAGATA 240 CACmCTCA CCAAATGTGC CTTTCAGCCC CCCCCCAGCT GTCTTCGCTT CGTCCAGACC 300 AACATCTCCC GCCTCCTGCA GGAGACCTCC GAGCAGCTGG TGGCGCTGAA GCCCTGGATC 360 ACTCGCCAGA ACTTCTCCCG GTGCCTGGAG CTGCAGTGTC AGCCCTACGT AGAGGGCGGT 420 GGAGGCTCCC CGGGTGAACC GTCTGGTCCA ATCTCTACTA TCAACCCGTC TCCTCCGTCT 480 AAAGAATCTC ATAAATCTCC AAACATGGCT AACTGCTCTA TAATGATCGA TGAAATTATA 540 CATCACTTAA AGAGACCACC TAACCCTTTG CTGGACCCGA ACAACCTCAA TTCTGAAGAC 600 ATGGATATCC TGATGGAACG AAACCTTCGA ACTCCAAACC TGCTCGCATT CGTAAGGGCT 660 GTCAAGCACT TAGAAAATGC ATCAGGTATT GAGGCAATTC TTCGTAATCT CCAACCATGT 720 CTGCCCTCTG CCACGGCCGC ACCCTCTCGA CATCCAATCA TCATCAAGGC AGGTGACTGG 780 CAAGAATTCC GGGAAAAACT GACGTTCTAT CTGCTTACCC TTGAGCAAGC GCAGGAACAA 840 CAG 843 (2)序列編號NO: 132資料： ⑴序列特性： (A) 長度：888鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 132 GCTAACTGCT CTATAATGAT CGATGAMTT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CAATTCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 mGKGGCPA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 tatctgg™ CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CCAACATGGC CGACGAGGAG CTCTGCGGGG GCCTCTGGCG GCTGGTCCTG 480 GCACAGCGCT GGATGGAGCG GCTCAAGACT GTCGCTGGGT CCAAGATGCA AGGCTTGCTG 540 GAGCGCGTGA ACACGGAGAT ACACTTTGTC ACCAAATGTG CCTITCAGCC CCCCCCCAGC 600 TGTCTTCGCT TCGTCCAGAC CAACATCTCC CGCCTCCTGC AGGAGACCTC CGAGCAGCTG 660 GTGGCGCTGA AGCCCTGGAT CACTCGCCAG AACTTCTCCC GGTGCCTGGA GCTGCAGTGT 720 CAGCCCGACT CCTCAACCCT GTCAGGCGGT AACGGCAGTG GAGGTAATGG CACCCAGGAC 780 TGCTCCITCC AACACAGCCC CATCTCCTCC GACTTCGCTG TCAAAATCCG TGAGCTGTCT 840 O:\92\92747.DOC -72- 200413407 GACTACCTGC TTCAAGATTA CCCAGTCACC GTGGCCTCCA ACCTGCAG 888 (2)序列編號NO: 133資料： (i)序列特性： (A) 長度：903鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 133 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CAATTCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTMGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CGACGAGGAG CTCTGCGGGG GCCTCTGGCG GCTGGTCCTG 490 GCACAGCGCT GGATGGAGCG GCTCAAGACT GTCGCTGGGT CCAAGATGCA AGGCTTGCTG 540 GAGCGCGTGA ACACGGAGAT ACACTTTGTC ACCAAATGTG CCTTTCAGCC CCCCCCCAGC 600 TGTCTTCGCT TCGTCCAGAC CAACATCTCC CGCCTCCTGC AGGAGACCTC CGAGCAGCTG 660 GTGGCGCTGA AGCCCTGGAT CACTCGCCAG AACTTCTCCC GGTGCCTGGA GCTGCAGTGT 720 CAGCCCGACT CCTCAACCCT GTCTGGAGGT AACGGATCCG GTGGCAATGG GAGCGGCGGA 780 AATGGAACCC AGGACTGCTC CTTCCAACAC AGCCCCATCT CCTCCGACTT CGCTGTCAAA 840 ATCCGTGAGC TGTCTGACTA CCTGCTTCAA GATTACCCAG TCACCGTGGC CTCCAACCTG 900 CAG 903 (2)序列編號NO: 134資料 • (i)序列特性： (A)長度：873鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 134 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CMTTCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTMGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCCG TGGAGGCTCC 360 O:\92\92747.DOC -73- 200413407 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CTCCAAGATG CAAGGCTTGC TGGAGCGCGT GAACACGGAG 480 ATACACTTTG TCACCAAATG TGCCTTTCAG CCCCCCCCCA GCTGTCTTCG CTTCGTCCAG 540 ACCAACATCT CCCGCCTCCT GCAGGAGACC TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG 600 ATCACTCGCC AGAACTTCTC CCGGTGCCTG GAGCTGCAGT GTCAGCCCGA CTCCTCAACC 660 CTGTCTGGCG GCAACGGCAC GCAGGACTGC TCCTTCCAAC ACAGCCCCAT CTCCTCCGAC 720 TTCGCTGTCA AAATCCGTGA GCTGTCTGAC TACCTGCTTC AAGATTACCC AGTCACCGTG 780 GCCTCCAACC TGCAGGACGA GGAGCTCTGC GGGGGCCTCT GGCGGCTGGT CCTGGCACAG 840 CGCTGGATGG AGCGGCTCAA GACTGTCGCT GGG 873 (2)序列編號NO: 135資料： (i)序列特性： (A) 長度：888鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 135 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CAATTCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCITCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CTCCAAGATG CAAGGCTTGC TGGAGCGCGT GAACACGGAG 480 ATACACTTTG TCACCAAATG TGCCTTTCAG CCCCCCCCCA GCTGTCTTCG CTTCGTCCAG 540 ACCAACATCT CCCGCCTCCT GCAGGAGACC TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG 600 ATCACTCGCC AGAACTTCTC CCGGTGCCTG GAGCTGCAGT GTCAGCCCGA CTCCTCAACC 660 CTGTCTGGAG GTAACGGATC CGGAGGTAAT GGCACCCAGG ACTGCTCCTT CCAACACAGC 720 CCCATCTCCT CCGACTTCGC TGTCAAAATC CGTGAGCTGT CTGACTACCT GCTTCAAGAT 780 TACCCAGTCA CCGTGGCCTC CAACCTGCAG GACGAGGAGC TCTGCGGGGG CCTCTGGCGG 840 CTGGTCCTGG CACAGCGCTG GATGGAGCGG CTCAAGACTG TCGCTGGG 888 (2)序列編號NO: 136資料： (i)序列特性· (A) 長度：903鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 136 O:\92\92747.DOC -74- 200413407 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60* TTGCTGGACC CGAACAACCT CffiTCTGAAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CTCCAAGATG CAAGGCTTGC TGGAGCGCGT GAACACGGAG 480 ATACACTTTG TCACCAAATG TGCCITTCAG CCCCCCCCCA GCTGTCTTCG CTTCGTCCAG 540 ACCAACATCT CCCGCCTCCT GCAGGAGACC TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG 600 ATCACTCGCC AGAACTTCTC CCGGTGCCTG GAGCTGCAGT GTCAGCCCGA CTCCTCAACC 660 CTGTCTGGAG GTAACGGATC CGGTGGCAAT GGGAGCGGCG GAAATGGAAC CCAGGACTGC 720 TCCTTCCAAC ACAGCCCCAT CTCCTCCGAC TTCGCTGTCA AAATCCGTGA GCTGTCTGAC 780 TACCTGCTTC AAGATTACCC AGTCACCGTG GCCTCCAACC TGCAGGACGA GGAGCTCTGC 840 GGGGGCCTCT GGCGGCTGGT CCTGGCACAG CGCTGGATGG AGCGGCTCAA GACTGTCGCT 900 GGG 903 (2)序列編號NO: 137資料 ⑴序列特性： (A) 長度：873鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 137 GCTAACTGCT CTATAATGAT CGATGAAm ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CAATTCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CCCCCCCAGC TGTCTTCGCT TCGTCCAGAC CAACATCTCC 480 CGCCTCCTGC AGGAGACCTC CGAGCAGCTG GTGGCGCTGA AGCCCTGGAT CACTCGCCAG 540 AACTTCTCCC GGTGCCTGGA GCTGCAGTGT CAGCCCGACT CCTCAACCCT GTCTGGCGGC 600 AACGGCACGC AGGACTGCTC CTTCCAACAC AGCCCCATCT CCTCCGACTT CGCTGTCAAA 660 ATCCGTGAGC TGTCTGACTA CCTGCTTCAA GATTACCCAG TCACCGTGGC CTCCAACCTG 720 CAGGACGAGG AGCTCTGCGG GGGCCTCTGG CGGCTGGTCC TGGCACAGCG CTGGATGGAG 780 CGGCTCAAGA CTGTCGCTGG GTCCAAGATG CAAGGCTTGC TGGAGCGCGT GAACACGGAG 840 ATACACTTTG TCACCAAATG TGCCHTCAG CCC 873 (2)序列編號NO·· 138資料： (i)序列特性： (A)長度：888鹼基對 O:\92\92747.DOC 75- 200413407 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 138 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT TTGCTGGACC CGAACAACCT CAATTCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT ATTGAGGCAA ΉCΠCGΊkk TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT CATAAATCTC CAAACATGGC CCCCCCCAGC TGTCTTCGCT TCGTCCAGAC CAACATCTCC CGCCTCCTGC AGGAGACCTC CGAGCAGCTG GTGGCGCTGA AGCCCTGGAT CACTCGCCAG AACTTCTCCC GGTGCCTGGA GCTGCAGTGT CAGCCCGACT CCTCAACCCT GTCAGGCGGT AACGGCAGTG GAGGTAATGG CACCCAGGAC TGCTCCTTCC AACACAGCCC CATCTCCTCC GACTTCGCTG TCAAAATCCG TGAGCTGTCT GACTACCTGC TTCAAGATTA CCCAGTCACC GTGGCCTCCA ACCTGCAGGA CGAGGAGCTC TGCGGGGGCC TCTGGCGGCT GGTCCTGGCA CAGCGCTGGA TGGAGCGGCT CAAGACTGTC GCTGGGTCCA AGATGCAAGG CTTGCTGGAG CGCGTGAACA CGGAGATACA CTTTGTCACC AAATGTGCCT TTCAGCCC 888 (2)序列編號NO: 139資料： (i)序列特性： (A) 長度：903鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 139

GCTAACTGCT CTATAATGAT CGATGAAAH ATACATCACT TAAAGAGACC ACCTAACCCT TTGCTGGACC CGAACAACCT CAATTCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT AHGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT CATAAATCTC CAAACATGGC CCCCCCCAGC TGTCTTCGCT TCGTCCAGAC CAACATCTCC CGCCTCCTGC AGGAGACCTC CGAGCAGCTG GTGGCGCTGA AGCCCTGGAT CACTCGCCAG AACTTCTCCC GGTGCCTGGA GCTGCAGTGT CAGCCCGACT CCTCAACCCT GTCTGGAGGT AACGGCAGTG GTGGCAATGG GAGCGGCGGA AATGGAACCC AGGACTGCTC CTTCCAACAC AGCCCCATCT CCTCCGACTT CGCTGTCAAA ATCCGTGAGC TGTCTGACTA CCTGCTTCAA GATTACCCAG TCACCGTGGC CTCCAACCTG CAGGACGAGG AGCTCTGCGG • GGGCCTCTGG CGGCTGGTCC TGGCACAGCG CTGGATGGAG CGGCTCAAGA CTGTCGCTGG GTCCAAGATG CAAGGCTTGC CCC TGGAGCGCGT GAACACGGAG ATACACTTTG TCACCAAATG TGCCTTTCAG O:\92\92747.DOC -76- 200413407 (2)序列編號NO: 140資料： (i)序列特性： (A) 長度：888鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 140 GCTAACTGCT CTATAATGAT CGATGAMIT ATACATCACT TAAAGAGACC ACCTAACCCT 60 nGCTGGACC CGAACAACCT CMTTCTGM GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 AUGAGGCM TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CCAACATGGC CGACGAGGAG CTCTGCGGGG GCCTCTGGCG GCTGGTCCTG 480 GCACAGCGCT GGATGGAGCG GCTCAAGACT GTCGCTGGGT CCAAGATGCA AGGCTTGCTG 540 GAGCGCGTGA ACACGGAGAT ACACTTTGTC ACCAAATGTG CCTTTCAGCC CCCCCCCAGC 600 TGTCTTCGCT TCGTCCAGAC CAACATCTCC CGCCTCCTGC AGGAGACCTC CGAGCAGCTG 660 GTGGCGCTGA AGCCCTGGAT CACTCGCCAG AACTTCTCCC GGTGCCTGGA GCTGCAGTGT 720 CAGCCCGACT CCTCAACCCT GTCTGGAGGT AGTGGATCCG GAGGTTCTGG CACCCAGGAC 780 TGCTCCTTCC AACACAGCCC CATCTCCTCC GACTTCGCTG TCAAAATCCG TGAGCTGTCT 840 GACTACCTGC TTCAAGATTA CCCAGTCACC GTGCCCTCCA ACCTGCAG 888 (2)序列編號NO: 141資料： (i)序列特性： (A) 長度：903鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 141 GCTAACTGCT CTATAATGAT CGATGAMH ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CAATTCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CGACGAGGAG CTCTGCGGGG GCCTCTGGCG GCTGGTCCTG 480 GCACAGCGCT GGATGGAGCG GCTCAAGACT GTCGCTGGGT CCAAGATGCA AGGCTTGCTG 540 O:\92\92747.DOC -77- 200413407 GAGCGCGTGA ACACGGAGAT ACACITTGTC ACCAAATGTG CCTTTCAGCC CCCCCCCAGC 600 TGTCTTCGCT TCGTCCAGAC CAACATCTCC CGCCTCCTGC AGGAGACCTC CGAGCAGCTG 660 GTGGCGCTGA AGCCCTGGAT CACTCGCCAG AACTTCTCCC GGTGCCTGGA GCTGCAGTGT 720 CAGCCCGACT CCTCAACCCT GTCTGGAGGT AGTGGATCCG GTGGCAGTGG GAGCGGCGGA 780 TCTGGAACCC AGGACTGCTC CTTCCAACAC AGCCCCATCT CCTCCGACTT CGCTGTCAAA 840 ATCCGTGAGC TGTCTGACTA CCTGCTTCAA GATTACCCAG TCACCGTGGC CTCCAACCTG 900 CAG 903 (2)序列編號NO: 142資料 • ⑴序列特性： (A) 長度：858鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 142 GCCACCCAGG ACTGCTCCTT CCAACACAGC CCCATCTCCT CCGACTTCGC TGTCAAAATC 60 CGTGAGCTGT CTGACTACCT GCTTCAAGAT TACCCAGTCA CCGTGGCCTC CAACCTGCAG 120 GACGAGGAGC TCTGCGGGGG CCTCTGGCGG CTGGTCCTGG CACAGCGCTG GATGGAGCGG 180 CTCAAGACTG TCGCTGGGTC CAAGATGCAA GGCTTGCTGG AGCGCGTGAA CACGGAGATA 240 CACTTTGTCA CCAAATGTGC CTTTCAGCCC CCCCCCAGCT GTCTTCGCTT CGTCCAGACC 300 AACATCTCCC GCCTCCTGCA GGAGACCTCC GAGCAGCTGG TGGCGCTGAA GCCCTGGATC 360 ACTCGCCAGA ACTTCTCCCG GTGCCTGGAG CTGCAGTGTC AGCCCGACTC CTCAACCCTG 420 TACGTAGAGG GCGGTGGAGG CTCCCCGGGT GAACCGTCTG GTCCAATCTC TACTATCAAC 480 CCGTCTCCTC CGTCTAAAGA ATCTCATAAA TCTCCAAACA TGGCTAACTG CTCTATAATG 540 ATCGATGAAA TTATACATCA CTTAAAGAGA CCACCTAACC CnTGCTGGA CCCGAACAAC 600 CTCAATTCTG AAGACATGGA TATCCTGATG GAACGAAACC TTCGAACTCC AAACCTGCTC 660 GCATTCGTAA GGGCTGTCAA GCACITAGAA AATGCATCAG GTATTGAGGC AATTCTTCGT 720 AATCTCCAAC CATGTCTGCC CTCTGCCACG GCCGCACCCT CTCGACATCC AATCATCATC 780 AAGGCAGGTG ACTGGCAAGA ATOCGGGAA AAACTGACGT TCTATCTGGT TACCCTTGAG 840 CAAGCGCAGG AACAACAG 858 (2)序列編號NO: 143資料 : ⑴序列特性： (A) 長度：876鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 143 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CkmCiGkk GACATGGATA TCCTGATGGA ACGAAACCTT 120 O:\92\92747.DOC -78- 200413407 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CGACGAGGAG CTCTGCGGGG GCCTCTGGCG GCTGGTCCTG 480 GCACAGCGCT GGATGGAGCG GCTCAAGACT GTCGCTGGGT CCAAGATGCA AGGCTTGCTG 540 GAGCGCGTGA ACACGGAGAT ACACTTTGTC ACCAAATGTG CCTTTCAGCC CCCCCCCAGC 600 TGTCTTCGCT TCGTCCAGAC CAACATCTCC CGCCTCCTGC AGGAGACCTC CGAGCAGCTG 660 GTGGCGCTGA AGCCCTGGAT CACTCGCCAG AACTTCTCCC GGTGCCTGGA GCTGCAGTGT 720 CAGCCCGACT CCTCAACCCT GGGCGGTGGA TCCGGAGGTA CCCAGGACTG CTCCTTCCAA 780 CACAGCCCCA TCTCCTCCGA CTTCGCTGTC AAAATCCGTG AGCTGTCTGA CTACCTGCTT 840 CAAGATTACC CAGTCACCGT GGCCTCCAAC CTGCAG 876 (2)序列編號NO: 144資料： (i)序列特性： (A) 長度：879鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 144 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CMITCTGM GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CGACGAGGAG CTCTGCGGGG GCCTCTGGCG GCTGGTCCTG 480 GCACAGCGCT GGATGGAGCG GCTCAAGACT GTCGCTCjGCT CCAAGATGCA AGGCTTGCTG 540 GAGCGCGTGA ACACGGAGAT ACACTTTGTC ACCAAATGTG CCTTTCAGCC CCCCCCCAGC 600 TGTCTTCGCT TCGTCCAGAC CAACATCTCC CGCCTCCTGC AGGAGACCTC CGAGCAGCTG 660 GTGGCGCTGA AGCCCTGGAT CACTCGCCAG AACTTCTCCC GGTGCCTGGA GCTGCAGTGT 720 CAGCCCGACT CCTCAACCCT GGGCGGTGGA TCCGGAGGTG GCACCCAGGA CTGCTCCrrC 780 CAACACAGCC CCATCTCCTC CGACTTCGCT GTCAAAATCC GTGAGCTGTC TGACTACCTG 840 CTTCAAGATT ACCCAGTCAC CGTGGCCTCC AACCTGCAG 879 (2)序列編號NO: 145資料 • ⑴序列特性： (A) 長度：888鹼基對 (B) 形式：核酸 (C) 股數：單 O:\92\92747.DOC -79- 200413407 (D)拓撲結構：線形 (xi)序列描述：序列編號NO: 145 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CAATTCTGAA GACATGGATA TCCTGATGGA ACGuSCCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 tatctgg™ CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 cCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CGACGAGGAG CTCTGCGGGG GCCTCTGGCG CCTGGTCCTG 480 GCACAGCGCT GGATGGAGCG GCTCAAGACT GTCGCTGGGT CCAAGATGCA AGGCTTGCTG 540 GAGCGCGTGA ACACGGAGAT ACACTTTGTC ACCAAATGTG CCTTTCAGCC CCCCCCCAGC 600 TGTCTTCGCT TCGTCCAGAC CAACATCTCC CGCCTCCTGC AGGAGACCTC CGAGCAGCTG 660 GTGGCGCTGA AGCCCTGGAT CACTCGCCAG AACTTCTCCC GGTGCCTGGA GCTGCAGTGT 720 CAGCCCGACT CCTCAACCCT GGGCGGTGGG TCAGGAGGTG GATCCGGAGG TACCCAGGAC 780 TGCTCCTTCC AACACAGCCC CATCTCCTCC GACTTCGCTG TCAAAATCCG TGAGCTGTCT 840 GACTACCTGC TTCAAGATTA CCCAGTCACC GTGGCCTCCA ACCTGCAG 888

(2)序列編號NO·· 146資料： (i)序列特性： (A) 長度：897鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 146 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CAATTCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CGACGAGGAG CTCTGCGGGG GCCTCTGGCG GCTGGTCCTG 480 GCACAGCGCT GGATGGAGCG GCTCAAGACT GTCGCTGGGT CCAAGATGCA AGGCTTGCTG 540 GAGCGCGTGA ACACGGAGAT ACACTTTGTC ACCAAATGTG cCHTCAGCC CCCCCCCAGC 600 TGTCTTCGCT TCGTCCAGAC CAACATCTCC CGCCTCCTGC AGGAGACCTC CGAGCAGCTG 660 GTGGCGCTGA AGCCCTGGAT CACTCGCCAG AACTTCTCCC GGTGCCTGGA GCTGCAGTGT 720 CAGCCCGACT CCTCAACCCT GGGCGGTGGA TCCGGAGGTG GCTCAGGGGG AGGTAGTGGT 780 ACCCAGGACT GCTCCTTCCA ACACAGCCCC ATCTCCTCCG ACTTCGCTGT CAAAATCCGT 840 GAGCTGTCTG ACTACCTGCT TCAAGAmC CCAGTCACCG TGGCCTCCAA CCTGCAG 897

(2)序列編號NO: 147資料： O:\92\92747.DOC -80- 200413407 ⑴序列特性： (A) 長度：903鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO·· 147 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CAATTCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGC5GCGG TGGAGGCTCC 360 CCGCXjTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CGACGAGGAG CTCTGCGGGG GCCTCTGGCG GCTGGTCCTG 480 GCACAGCGCT GGATGGAGCG GCTCAAGACT GTCGCTGC5GT CCAAGATGCA AGGCTTGCTG 540 GAGCGCGTGA ACACGGAGAT ACACTTTGTC ACCAAATGTG CCTTTCAGCC CCCCCCCAGC 600 TGTCITCGCT TCGTCCAGAC CAACATCTCC CGCCTCCTGC AGGAGACCTC CGAGCAGCTG 660 GTGGCGCTGA AGCCCTGGAT CACTCGCCAG AACTTCTCCC GGTGCCTGGA GCTGCAGTGT 720 CAGCCCGACT CCTCAACCCT GGGCGGTGGG TCAGGAGGTG GGTCAGGAGG TGGATCCGGA 780 GGTGGCACCC AGGACTGCTC CTTCCAACAC AGCCCCATCT CCTCCGACTT CGCTGTCAAA 840 ATCCGTGAGC TGTCTGACTA CCTGCTTCAA GATTACCCAG TCACCGTGGC CTCCAACCTG 900 CAG 903 (2)序列編號NO: 148資料： (i)序列特性： (A) 長度：921鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 148 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CAATTCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CGACGAGGAG CTCTGCGGGG GCCTCTGGCG GCTGGTCCTG 480 GCACAGCGCT GGATGGAGCG GCTCAAGACT GTCGCTGGGT CCAAGATGCA AGGCTTGCTG 540 GAGCGCGTGA ACACGGAGAT ACACTTTGTC ACCAAATGTG CCTTTCAGCC CCCCCCCAGC 600 TGTCTTCGCT TCGTCCAGAC CAACATCTCC CGCCTCCTGC AGGAGACCTC CGAGCAGCTG 660 O:\92\92747.DOC -81- 200413407 iv /IV /(V /IV - - 2 8 4 0 2 7 7 8 9 9

GTGGCGCTGA AGCCCTGGAT CACTCGCCAG AACTTCTCCC GGTGCCTGGA GCTGCAGTGT

CAGCCCGACT CCTCAACCCT GGGCGGTGGG TCAGGAGGTG GGTCAGGAGG TGGATCCGGA

GGTGGCTCAG GGGGAGGTAG TGGTACCCAG GACTGCTCCT TCCAACACAG CCCCATCTCC

TCCGACTTCG CTGTCAAAAT CCGTGAGCTG TCTGACTACC TGCTTCAAGA TTACCCAGTC

ACCGTGGCCT CCAACCTGCA G (2)序列編號NO: 149資料： (i)序列特性： (A)長度：876鹼基對 •(B)形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO·· 149 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT TTGCTGGACC CGAACAACCT CAATTCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT AnGAGGCAA TTCTTCGTAA TCTCCMCCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT CATAAATCTC CAAACATGGC CTCCAAGATG CAAGGCTTGC TGGAGCGCGT GAACACGGAG ATACACTTTG TCACCAAATG TGCCTTTCAG CCCCCCCCCA GCTGTCTTCG CTTCGTCCAG ACCAACATCT CCCGCCTCCT GCAGGAGACC TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG ATCACTCGCC AGAACTTCTC CCGGTGCCTG GAGCTGCAGT GTCAGCCCGA CTCCTCAACC CTGGGCGGTG GATCCGGAGG TACCCAGGAC TGCTCCTTCC AACACAGCCC CATCTCCTCC GACTTCGCTG TCAAAATCCG TGAGCTGTCT GACTACCTGC TTCAAGATTA CCCAGTCACC GTGGCCTCCA ACCTGCAGGA CGAGGAGCTC TGCGGGGGCC TCTGGCGGCT GGTCCTGGCA CAGCGCTGGA TGGAGCGGCT CAAGACTGTC GCTGGG (2)序列編號NO: 150資料： 000000000000006 628406284062847 11233445667788 ⑴序列特性： (A)長度：879鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 150

GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT

TTGCTGGACC CGAACAACCT CAAnCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT

CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT

ATTGAGGCAA TTCTTCGTAA TCTCCMCCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT O:\92\92747.DOC -82- 200413407 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC tatctgg™ CCCTTGAGCA AGCGCAGGAA CAACAGTACC TAGAGGGCGG TGGAGGCTCC CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT CATAAATCTC CAAACATGGC CTCCAAGATG CAAGGCTTGC TGGAGCGCGT GAACACGGAG ATACACTITG TCACCAAATG TGCCTTTCAG CCCCCCCCCA GCTGTCTTCG CTTCGTCCAG ACCAACATCT CCCGCCTCCT GCAGGAGACC TCCGAGCAGC TGGTGGCGCT CAAGCCCTGG ATCACTCGCC AGAACTTCTC CCGGTGCCTG GAGCTGCAGT GTCAGCCCGA CTCCTCAACC CTGGGCGGTG GATCCGGAGG TGGCACCCAG GACTGCTCCT TCCAACACAG CCCCATCTCC TCCGACITCG CTGTCAAAAT CCGTGAGCTG TCTGACTACC TGCTTCAAGA TTACCCAGTC ACCGTGGCCT CCAACCTGCA GGACGAGGAG CTCTGCGGGG GCCTCTGGCG GCTGGTCCTG GCACAGCGCT GGATGGAGCG GCTCAAGACT GTCGCTGGG (2)序列編號NO: 1 5 1資料 ⑴序列特性： (A) 長度：888鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 151 GCTAACTGCT CTATAATGAT CGATGAMH ATACATCACT TAAAGAGACC ACCTAACCCT nGCTGGACC CGAACAACCT CAATTCTGM GACATGGATA TCCTGATGGA ACGAAACCTT CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAACAATCT CATAAATCTC CAAACATGGC CTCCAAGATG CAAGGCTTGC TGGAGCGCGT GAACACGGAG ATACACTTTG TCACCAAATG TGCCTTTCAG CCCCCCCCCA GCTGTCTTCG CTTCGTCCAG ACCAACATCT CCCGCCTCCT GCAGGAGACC TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG ATCACTCGCC AGAACTTCTC CCGGTGCCTG GAGCTGCAGT GTCAGCCCGA CTCCTCAACC CTGGGCGGTG GGTCAGGAGG TGGATCCGGA GGTACCCAGG ACTGCTCCTT CCAACACAGC CCCATCTCCT CCGACTTCGC TGTCAAAATC CGTGAGCTGT CTGACTACCT GCTTCAAGAT TACCCAGTCA CCGTGGCCTC CAACCTGCAG GACGAGGAGC TCTGCGGGGG CCTCTGGCGG CTGGTCCTGG CACAGCGCTG GATGGAGCGG CTCAnGACTG TCGCTGGG (2)序列編號NO·· 152資料 ⑴序列特性： (A)長度：897鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 O:\92\92747.DOC .83- 200413407 (xi)序列描述：序列編號NO: 152 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CAATTCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CTCCAAGATG CAAGGCTTGC TGGAGCGCGT GAACACGGAG 480 ATACACTITG TCACCAAATG TGCOTTCAG CCCCCCCCCA GCTGTCTTCG CTTCGTCCAG 540 ACCAACATCT CCCGCCTCCT GCAGGAGACC TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG 600 ATCACTCGCC AGAACTTCTC CCGGTGCCTG GAGCTGCAGT GTCAGCCCGA CTCCTCAACC 660 CTGGGCGGTG GATCCGGAGG TGGCTCAGGG GGAGGTAGTG GTACCCAGGA CTGCTCCTTC 720 CAACACAGCC CCATCTCCTC CGACTTCGCT GTCAAAATCC GTGAGCTGTC TGACTACCTG 780 CTTCAAGATT ACCCAGTCAC CGTGGCCTCC AACCTGCAGG ACGAGGAGCT CTGCGGGGGC 840 CTCTGGCGGC TGGTCCTGGC ACAGCGCTGG ATGGAGCGGC TCAAGACTGT CGCTGGG 897 (2)序列編號NO: 153資料：

⑴序列特性： (A) 長度：903鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 153 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CAATTCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CTCCAAGATG CAAGGCTTGC TGGAGCGCGT GAACACGGAG 480 ATACACTTTG TCACCAAATG TGCCTTTCAG CCCCCCCCCA GCTGTCTTCG CTTCGTCCAG 540 ACCAACATCT CCCGCCTCCT GCAGGAGACC TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG 600 ATCACTCGCC AGAACTTCTC CCGGTGCCTG GAGCTGCAGT GTCAGCCCGA CTCCTCAACC 660 CTGGGCGGTG GGTCAGGAGG TGGGTCAGGA GGTGGATCCG GAGGTGGCAC CCAGGACTGC 720 TCCTTCCAAC ACAGCCCCAT CTCCTCCGAC TTCGCTGTCA AAATCCGTGA GCTGTCTGAC 780 TACCTGCTTC AAGATTACCC AGTCACCGTG GCCTCCAACC TGCAGGACGA GGAGCTCTGC 840 GGGGGCCTCT GGCGGCTGGT CCTGGCACAG CGCTGGATGG AGCGGCTCAA GACTGTCGCT 900 GGG 903 (2)序列編號NO: 154資料：

⑴序列特性： O:\92\92747.DOC -84- 200413407 (A) 長度：921鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 154 GCTAACTGCT CTATAATGAT CGATGAMTT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CAAnCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGCCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CTCCAAGATG CAAGGCTTGC TGGAGCGCGT GAACACGGAG 480 ATACACITTG TCACCAAATG TGCCTTTCAG CCCCCCCCCA GCTGTCTTCG CTTCGTCCAG 540 ACCAACATCT CCCGCCTCCT GCAGGAGACC TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG 600 ATCACTCGCC AGAACTTCTC CCGGTGCCTG GAGCTGCAGT GTCAGCCCGA CTCCTCAACC 660 CTGGGCGGTG GGTCAGGAGG TGGGTCAGGA GGTGGATCCG GAGGTGGCTC AGGGGGAGGT 720 AGTGGTACCC AGGACTGCTC CTTCCAACAC AGCCCCATCT CCTCCGACTT CGCTGTCAAA 780 ATCCGTGAGC TGTCTGACTA CCTGCTTCAA GATTACCCAG TCACCGTGGC CTCCAACCTG 840 CAGGACGAGG AGCTCTGCGG GGGCCTCTGG CGGCTGGTCC TGGCACAGCG CTGGATGGAG 900 CGGCTCAAGA CTGTCGCTGG G 921 (2)序列編號NO: 155資料： (i)序列特性： (A) 長度：876鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 155 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 nGCTGGACC CGAACAACCT CAATTCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CCCCCCCAGC TGTCITCGCT TCGTCCAGAC CAACATCTCC 480 CGCCTCCTGC AGGAGACCTC CGAGCAGCTG GTGGCGCTGA AGCCCTGGAT CACTCGCCAG 540 AACTTCTCCC GGTGCCTGGA GCTGCAGTGT CAGCCCGACT CCTCAACCCT GGGCGGTGGA 600 TCCGGAGGTA CCCAGGACTG CTCCTTCCAA CACAGCCCCA TCTCCTCCGA CTTCGCTGTC 660 AAAATCCGTG AGCTGTCTGA CTACCTGCTT CAAGAmCC CAGTCACCGT GGCCTCCAAC 720 CTGCAGGACG AGGAGCTCTG CGGGGGCCTC TGGCGGCTGG TCCTGGCACA GCGCTGGATG 780 O:\92\92747.DOC -85- 200413407 GAGCGGCTCA AGACTGTCGC TGGGTCCAAG ATGCAAGGCT TGCTGGAGCG CGTGAACACG 840 GAGATACACT TTGTCACCAA ATGTGCCTTT CAGCCC 876 (2)序列編號NO: 156資料： (i)序列特性： (A) 長度：879鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 156 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CMTTCTGM GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CCCCCCCAGC TGTCTTCGCT TCGTCCAGAC CAACATCTCC 480 CGCCTCCTGC AGGAGACCTC CGAGCAGCTG GTGGCGCTGA AGCCCTGGAT CACTCGCCAG 540 AACTTCTCCC GGTGCCTGGA GCTGCAGTGT CAGCCCGACT CCTCAACCCT GGGCGGTGGA 600 TCCGGAGGTG GCACCCAGGA CTGCTCCTTC CAACACAGCC CCATCTCCTC CGACTTCGCT 660 GTCAAAATCC GTGAGCTGTC TGACTACCTG CTTCAAGATT ACCCAGTCAC CGTGGCCTCC 720 AACCTGCAGG ATGAGGAGCT CTGCGGGGGC CTCTGGCGGC TGGTCCTGGC ACAGCGCTGG 780 ATGGAGCGGC TCAAGACTGT CGCTGGGTCC AAGATGCAAG GCTTGCTGGA GCGCGTGAAC 840 ACGGAGATAC ACTTTGTCAC CAAATGTGCC TTTCAGCCC 879 (2)序列編號NO: 157資料： (i)序列特性： (A) 長度：888鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO·. 157 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CAATTCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 O:\92\92747.DOC -86- 200413407 CATAAATCTC CAAACATGGC CCCCCCCAGC TGTCTTCGCT TCGTCCAGAC CAACATCTCC 480 CGCCTCCTGC AGGAGACCTC CGAGCAGCTG GTGGCGCTGA AGCCCTGGAT CACTCGCCAG 540 AACTTCTCCC GGTGCCTGGA GCTGCAGTGT CAGCCCGACT cCTCAACCCT GGGCGGTGGG 600 TCAGGAGGTG GATCCGGAGG TACCCAGGAC TGCTCCTTCC AACACAGCCC CATCTCCTCC 660 GACTTCGCTG TCAAAATCCG TGAGCTGTCT GACTACCTGC ttcaaga™ CCCAGTCACC 720 GTGGCCTCCA ACCTGCAGGA CGAGGAGCTC TGCGGGGGCC TCTGGCGGCT GGTCCTGGCA 780 CAGCGCTGGA TGGAGCGGCT CAAGACTGTC GCTGGGTCCA AGATGCAAGG CTTGCTGGAG 840 CGCGTGAACA CGGAGATACA CTTTGTCACC AAATGTGCCT TTCAGCCC 888 (2)序列編號NO: 158資料 ·· ⑴序列特性： (A) 長度：897鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 158 GCTAACTGCT CTATAATGAT CGATGAMTT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CAATTCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 AHGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCITGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CCCCCCCAGC TGTCTTCGCT TCGTCCAGAC CAACATCTCC 480 CGCCTCCTGC AGGAGACCTC CGAGCAGCTG GTGGCGCTGA AGCCCTGGAT CACTCGCCAG 540 AACTTCTCCC GGTGCCTGGA GCTGCAGTGT CAGCCCGACT CCTCAACCCT GGGCGGTGGA 600 TCCGGAGGTG GCTCAGGC5GG AGGTAGTGGT ACCCAGGACT GCTCCTTCCA ACACAGCCCC 660 ATCTCCTCCG ACTTCGCTGT CAAAATCCGT GAGCTGTCTG ACTACCTGCT TCAAGATTAC 720 CCAGTCACCG TGGCCTCCAA CCTGCAGGAC GAGGAGCTCT GCGGGGGCCT CTGGCGGCTG 780 GTCCTGGCAC AGCGCTGGAT GGAGCGGCTC AAGACTGTCG CTGGGTCCAA GATGCAAGGC 840 TTGCTGGAGC GCGTGAACAC GGAGATACAC TTTGTCACCA AATGTGCCTT TCAGCCC 897 (2)序列編號NO: 159資料： (i)序列特性： (A) 長度：903鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 159 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 O:\92\92747.DOC -87- 200413407

TTGCTGGACC CGAACAACCT CAATTCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT ATTGAGGCAA TTCITCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT CATAAATCTC CAAACATGGC CCCCCCCAGC TGTCTTCGCT TCGTCCAGAC CAACATCTCC CGCCTCCTGC AGGAGACCTC CGAGCAGCTG GTGGCGCTGA AGCCCTGGAT CACTCGCCAG AACTTCTCCC GGTGCCTGGA GCTGCAGTGT CAGCCCGACT CCTCAACCCT GGGCGGTGGG TCAGGAGGTG GGTCAGGAGG TGGATCCGGA GGTGGCACCC AGGACTGCTC CTTCCAACAC AGCCCCATCT CCTCCGACTT CGCTGTCAAA ATCCGTGAGC TGTCTGACTA CCTGCTTCAA GATTACCCAG TCACCGTGGC CTCCAACCTG CAGGACGAGG AGCTCTGCGG GGGCCTCTGG CGGCTGGTCC TGGCACAGCG CTGGATGGAG CGGCTCAAGA CTGTCGCTGG GTCCAAGATG CAAGGCTTGC TGGAGCGCGT GAACACGGAG ATACACTTTG TCACCAAATG TGCCTTTCAG

/IV /IV /(V /IV /IV ίν Γν /ίν Γν Γν Γν Γ i Γν -·' I 284062840628400 112334456677899 ccc (2)序列編號NO: 160資料： (i)序列特性： (A) 長度：921鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 160

GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT TTGCTGGACC CGAACAACCT CAATTCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT ATTGAGGCAA ΉCΠCG^^k TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT CATAAATCTC CAAACATGGC CCCCCCCAGC TGTCTTCGCT TCGTCCAGAC CAACATCTCC CGCCTCCTGC AGGAGACCTC CGAGCAGCTG GTGGCGCTGA AGCCCTGGAT CACTCGCCAG AACTTCTCCC GGTGCCTGGA GCTGCAGTGT CAGCCCGACT CCTCAACCCT GGGCGGTGGG TCAGGAGGTG GGTCAGGAGG TGGATCCGGA GGTGGCTCAG GGGGAGGTAG TGGTACCCAG GACTGCTCCT TCCAACACAG CCCCATCTCC TCCGACTTCG CTGTCAAAAT CCGTGAGCTG TCTGACTACC TGCTTCAAGA TTACCCAGTC ACCGTGGCCT CCAACCTGCA GGACGAGGAG CTCTGCGGGG GCCTCTGGCG GCTGGTCCTG GCACAGCGCT GGATGGAGCG GCTCAAGACT GTCGCTGGGT CCAAGATGCA AGGCTTGCTG GAGCGCGTGA ACACGGAGAT ACACTTTGTC ACCAAATGTG COTTCAGCC C 60 οοοοοοοοοοοοοοι 284062840628402 -—-10^334456677899 (2)序列編號NO: 161資料： (i)序列特性： (A)長度：888鹼基對 O:\92\92747.DOC -88- 200413407 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 161 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CAAnCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 tatctgg™ CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CGATTACCCA GTCACCGTGG CCTCCAACCT GCAGGACGAG 480 GAGCTCTGCG GGGGCCTCTG GCGGCTGGTC CTGGCACAGC GCTGGATGGA GCGGCTCAAG 540 ACTGTCGCTG GGTCCAAGAT GCAAGGCTTG CTGGAGCGCG TGAACACGGA GATACACTIT 600 GTCACCAAAT GTGCCTITCA GCCCCCCCCC AGCTGTCTTC GCTTCGTCCA GACCAACATC 660 TCCCGCCTCC TGCAGGAGAC CTCCGAGCAG CTGGTGGCGC TGAAGCCCTG GATCACTCGC 720 CAGAACTTCT CCCGGTGCCT GGAGCTGCAG TGTCAGCCCG ACTCCTCAAC CCTGGGCGGT 780 GGGTCAGGAG GTGGATCCGG AGGTACCCAG GACTGCTCCT TCCAACACAG CCCCATCTCC 840 TCCGACTTCG CTGTCAAAAT CCGTGAGCTG TCTGACTACC TGCTTCAA 888 (2)序列編號NO·. 162資料： (i)序列特性： (A) 長度：903鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 162 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTCCTGGACC CGAACAACCT CAAnCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CGAmCCCA GTCACCGTGG CCTCCAACCT GCAGGACGAG 480 GAGCTCTGCG GGGGCCTCTG GCGGCTGGTC CTGGCACAGC GCTGGATGGA GCGGCTCAAG 540 ACTGTCGCTG GGTCCAAGAT GCAAGGCTTG CTGGAGCGCG TGAACACGGA GATACACTTT 600 GTCACCAAAT GTGCCTTTCA GCCCCCCCCC AGCTGTCTTC GCTTCGTCCA GACCAACATC 660 TCCCGCCTCC TGCAGGAGAC CTCCGAGCAG CTGGTGGCGC TGAAGCCCTG GATCACTCGC 720 CAGAACTTCT CCCGGTGCCT GGAGCTGCAG TGTCAGCCCG ACTCCTCAAC CCTGGGCGGT 780 GGGTCAGGAG GTGGGTCAGG AGGTGGATCC GGAGGTGGCA CCCAGGACTG CTCCTTCCAA 840 CACAGCCCCA TCTCCTCCGA CTTCGCTGTC AAAATCCGTG AGCTGTCTGA CTACCTGCTT 900 O:\92\92747.DOC -89- 200413407 CM 903 (2)序列編號NO: 163資料： (i)序列特性· (A) 長度：888鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 163 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CAATTCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAACC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTCCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CGCCTCCAAC CTGCAGGACG AGGAGCTCTG CGGGGGCCTC 480 TGGCGGCTGG TCCTGGCACA GCGCTGGATG GAGCGGCTCA AGACTGTCGC TGGGTCCAAG 540 ATGCAAGGCT TGCTGGAGCG CGTGAACACG GAGATACACT TTGTCACCAA ATGTGCCTTT 600 CAGCCCCCCC CCAGCTGTCT TCGCTTCGTC CAGACCAACA TCTCCCGCCT CCTGCAGGAG 660 ACCTCCGAGC AGCTGGTGGC GCTGAAGCCC TGGATCACTC GCCAGAACTT CTCCCGGTGC 720 CTGGAGCTGC AGTGTCAGCC CGACTCCTCA ACCCTGC5GCG GTGGGTCAGG AGGTGGATCC 780 GGAGGTACCC AGGACTGCTC CTTCCAACAC AGCCCCATCT CCTCCGACTT CGCTGTCAAA 840 ATCCGTGAGC TGTCTGACTA CCTGCTTCAA GATTACCCAG TCACCGTG 888 (2)序列編號NO: 164資料： (i)序列特性： (A) 長度：903鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 164 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CAATTCTGAA GACATGGATA TCCTGATCGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAAGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CGCCTCCAAC CTGCAGGACG AGGAGCTCTG CGGGGGCCTC 480 O:\92\92747.DOC -90- 200413407 TGGCGGCTGG TCCTGGCACA GCGCTGGATG GAGCGGCTCA AGACTGTCGC TGGGTCCAAG 540 ATGCAAGGCT TGCTGGAGCG CGTGAACACG GAGATACACT TTGTCACCAA ATGTCCCTTT 600 CAGCCCCCCC CCAGCTGTCT TCGCTTCGTC CAGACCAACA TCTCCCGCCT CCTGCAGGAG 660 ACCTCCGAGC AGCTGGTGGC GCTGAAGCCC TGGATCACTC GCCAGAACTT CTCCCGGTGC 720 CTGGAGCTGC AGTGTCAGCC CGACTCCTCA ACCCTGGGCG GTGGGTCAGG AGGTGGGTCA 780 GGAGGTGGAT CCGGAGGTGG CACCCAGGAC TGCTCCTTCC AACACAGCCC CATCTCCTCC 840 GACTTCGCTG TCAAAATCCG TGAGCTGTCT GACTACCTGC TTCAAGAm CCCAGTCACC 900 GTG 903 (2)序列編號ΝΟ_· 165資料 • (i)序列特性· (A) 長度：888鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 165 GCTAACTGCT CTATAATGAT CGATGAA/OT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CAATTCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCITCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CGTCGCTGGG TCCAAGATGC AAGGCTTGCT GGAGCGCGTG 480 AACACGGAGA TACACTTTGT CACCAAATGT GCCTTTCAGC CCCCCCCCAG CTGTCTTCGC 540 TTCGTCCAGA CCAACATCTC CCGCCTCCTG CAGGAGACCT CCGAGCAGCT GGTGGCGCTG 600 AAGCCCTGGA TCACTCGCCA GAACTTCTCC CGGTGCCTGG AGCTGCAGTG TCAGCCCGAC 660 TCCTCAACCC TCGGCGGTGG GTCAGGAGGT GGATCCGGAG GTACCCAGGA CTGCTCCTTC 720 CAACACAGCC CCATCTCCTC CGACTTCGCT GTCAAAATCC GTGAGCTGTC TGACTACCTG 780 CTTCAAGATT ACCCAGTCAC CGTGGCCTCC AACCTGCAGG ACGAGGAGCT CTGCGGGGGC 840 CTCTGGCGGC TGGTCCTGGC ACAGCGCTGG ATGGAGCGGC TCAAGACT 888 (2)序列編號NO·· 166資料： (i)序列特性： (A) 長度：903鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 166 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 O:\92\92747.DOC -91- 200413407 TTGCTGGACC CGAACAACCT CMTTCTGM GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA ttcttcgtaa TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CGTCGCTGGG TCCAAGATGC AAGGCTTGCT GGAGCGCGTG 480 AACACGGAGA TACACTTTGT CACCAAATGT GCCTTTCAGC CCCCCCCCAG CTGTCTTCGC 540 TTCGTCCAGA CCAACATCTC CCGCCTCCTG CAGGAGACCT CCGAGCAGCT GGTGGCGCTG 600 AAGCCCTGGA TCACTCGCCA GAACTTCTCC CGGTGCCTGG AGCTGCAGTG TCAGCCCGAC 660 TCCTCAACCC TGGGCGGTGG GTCAGGAGGT GGGTCAGGAG GTGGATCCGG AGGTGGCACC 720 CAGGACTGCT CCTTCCAACA CAGCCCCATC TCCTCCGACT TCGCTGTCAA AATCCGTGAG 780 CTGTCTGACT ACCTGCTTCA AGAmCCCA GTCACCGTGG CCTCCAACCT GCAGGACGAG 840 GAGCTCTGCG GGGGCCTCTG GCGGCTGGTC CTGGCACAGC GCTGGATGGA GCGGCTCAAG 900 ACT 903

(2)序列編號NO: 167資料： (i)序列特性： (A) 長度：888鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 167 GCTAACTGCT CTATAATGAT CGATGAAiVTT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CAATTCTGM GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGm CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CCGCTTCGTC CAGACCAACA TCTCCCGCCT CCTGCAGGAG 480 ACCTCCGAGC AGCTGGTGGC GCTGAAGCCC TGGATCACTC GCCAGAACTT CTCCCGGTGC 540 CTGGAGCTGC AGTGTCAGCC CGACTCCTCA ACCCTGGGCG GTGGGTCAGG AGGTGGATCC 600 GGAGGTACCC AGGACTGCTC CTTCCAACAC AGCCCCATCT CCTCCGACTT CGCTGTCAAA 660 ATCCGTGAGC TGTCTGACTA CCTGCTTCAA GAmCCCAG TCACCGTGGC CTCCAACCTG 720 CAGGACGAGG AGCTCTGCGG GGGCCTCTGG CGGCTGGTCC TGGCACAGCG CTGGATGGAG 780 CGCCTCAAGA CTGTCGCTGG GTCCAAGATG CAAGGCTTGC TGGAGCGCGT GAACACGGAG 840 ATACACTTTG TCACCAAATG TGCCTTTCAG CCCCCCCCCA GCTGTCTT 888

(2)序列編號NO: 168資料： (i)序列特性： (A) 長度：903鹼基對 (B) 形式：核酸 O:\92\92747.DOC -92- 200413407 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 168 GCTAACTGCT CTATAATGAT CGMGkkm ATACATCACT TAAAGAGACC ACCTAACCCT 60 nGCTGGACC CGAACAACCT CAATTCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CCGCTTCGTC CAGACCAACA TCTCCCGCCT CCTGCAGGAG 480 ACCTCCGAGC AGCTGGTGGC GCTGAAGCCC TGGATCACTC GCCAGAACTT CTCCCGGTGC 540 CTGGAGCTGC AGTGTCAGCC CGACTCCTCA ACCCTGGGCG GTGGGTCAGG AGGTGGGTCA 600 GGAGGTGGAT CCGGAGGTGG CACCCAGGAC TGCTCCTTCC AACACAGCCC CATCTCCTCC 660 GACTTCGCTG TCAAAATCCG TGAGCTGTCT GACTACCTGC TTCMGATTA CCCAGTCACC 720 GTGGCCTCCA ACCTGCAGGA CGAGGAGCTC TGCGGGGGCC TCTGGCGGCT GGTCCTGGCA 780 CAGCGCTGGA TGGAGCGGCT CAAGACTGTC GCTGGGTCCA AGATGCAAGG CTTGCTGGAG 840 CGCGTGAACA CGGAGATACA CTTTGTCACC AAATGTGCCT TTCAGCCCCC CCCCAGCTGT 900 CTT 903

(2)序列編號NO: 169資料： (i)序列特性： (A) 長度：888鹼基對 (B) 形式：核酸 (C) 股數：單

(D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 169 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CAATTCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAAGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CACCAACATC TCCCGCCTCC TGCAGGAGAC CTCCGAGCAG 480 CTGGTGGCGC TGAAGCCCTG GATCACTCGC CAGAACTTCT CCCGGTGCCT GGAGCTGCAG 540 TGTCAGCCCG ACTCCTCAAC CCTGGGCGGT GGGTCAGGAG GTGGATCCGG AGGTACCCAG 600 GACTGCTCCT TCCAACACAG CCCCATCTCC TCCGACITCG CTGTCAAAAT CCGTGAGCTG 660 TCTGACTACC TGCTTCAAGA TTACCCAGTC ACCGTGGCCT CCAACCTGCA GGACGAGGAG 720 CTCTGCGGGG GCCTCTGGCG GCTGGTCCTG GCACAGCGCT GGATGGAGCG GCTCAAGACT 780 GTCGCTGGGT CCAAGATGCA AGGCTTGCTG GAGCGCGTGA ACACGGAGAT ACACTTTGTC 840 ACCAAATGTG CCTTTCAGCC CCCCCCCAGC TGTCTTCGCT TCGTCCAG 888 O:\92\92747.DOC •93- 200413407 (2)序列編號NO·· 170資料： (i)序列特性： (A) 長度·· 903鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 170 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CMTTCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CACCAACATC TCCCGCCTCC TGCAGGAGAC CTCCGAGCAG 480 CTGGTGGCGC TGAAGCCCTG GATCACTCGC CAGAACTTCT CCCGGTGCCT GGAGCTGCAG 540 TGTCAGCCCG ACTCCTCAAC CCTGGGCGGT GGGTCAGGAG GTGGGTCAGG AGGTGGATCC 600 GGAGGTGGCA CCCAGGACTG CTCCTTCCAA CACAGCCCCA TCTCCTCCGA CTTCGCTGTC 660 AAAATCCGTG AGCTGTCTGA CrACCTGCTT CAAGATTACC CAGTCACCGT GGCCTCCAAC 720 CTGCAGGACG AGGAGCTCTG CGGGGGCCTC TGGCGGCTGG TCCTGGCACA GCGCTGGATG m GAGCCjGCTCA AGACTGTCGC TGGGTCCAAG ATGCAAGGCT TGCTGGAGCG CGTGAACACG 840 GAGATACACT TTGTCACCAA ATGTGCCTTT CAGCCCCCCC CCAGCTGTCT TCGCTTCGTC 900 CAG 903 (2)序列編號NO: 171資料： (i)序列特性： (A) 長度：876鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 171 GCTAACTGCT CTATAATGAT CGATGAMIT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CAATTCTGM GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CGATTACCCA GTCACCGTGG CCTCCAACCT GCAGGACGAG 480 GAGCTCTGCG GGGGCCTCTG GCGGCTGGTC CTGGCACAGC GCTGGATGGA GCGGCTCAAG 540 O:\92\92747.DOC -94- 200413407 ACTGTCGCTG GGTCCAAGAT GCAAGGCTTG CTGGAGCGCG TGAACACGGA GATACACTTT 600 GTCACCAAAT GTGCCTTTCA GCCCCCCCCC AGCTGTCTTC GCTTCGTCCA GACCAACATC 660 TCCCGCCTCC TGCAGGAGAC CTCCGAGCAG CTGGTGGCGC TGAAGCCCTG GATCACTCGC 720 CAGAACTTCT CCCGGTGCCT GGAGCTGCAG TGTCAGCCCG ACTCCTCAAC CCTGGGCGGT 780 GGATCCGGAG GTACCCAGGA CTGCTCCTTC CAACACAGCC CCATCTCCTC CGACTTCGCT 840 GTCAAAATCC GTGAGCTGTC TGACTACCTG CTTCAA 876 (2)序列編號NO: 172資料 ! ⑴序列特性： (A) 長度：879鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 172 GCTAACTGCT CTATAATGAT CGATGAAm ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CMTTCTGM GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACITAGAAAA TGCATCAGGT 180 AnGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CGAmCCCA GTCACCGTGG CCTCCAACCT GCAGGACGAG 480 GAGCTCTGCG GGGGCCTCTG GCGGCTGGTC CTGGCACAGC GCTGGATGGA GCGGCTCAAG 540 ACTGTCGCTG GGTCCAAGAT GCAAGGCTTG CTGGAGCGCG TGAACACGGA GATACACTTT 600 GTCACCAAAT GTGCCTTTCA GCCCCCCCCC AGCTGTCTTC GCTTCGTCCA GACCAACATC 660 TCCCGCCTCC TGCAGGAGAC CTCCGAGCAG CTGGTGGCGC TGAAGCCCTG GATCACTCGC 720 CAGAACTTCT CCCGGTGCCT GGAGCTGCAG TGTCAGCCCG ACTCCTCAAC CCTGGGCGGT 780 GGATCCGGAG GTGGCACCCA GGACTGCTCC TTCCAACACA GCCCCATCTC CTCCGACTTC 840 GCTGTCAAAA TCCGTGAGCT GTCTGACTAC CTGCITCAA 879 (2)序列編號NO: 173資料： (i)序列特性： (A) 長度：897鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 173 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CMTrCTGM GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 O:\92\92747.DOC -95- 200413407 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGASTCT 420 CATAAATCTC CAAACATGGC CGATTACCCA GTCACCGTGG CCTCCAACCT GCAGGACGAG 480 GAGCTCTGCG GGGGCCTCTG GCGGCTGGTC CTGGCACAGC GCTGGATGGA GCGGCTCAAG 540 ACTGTCGCTG GGTCCAAGAT GCAAGGCTTG CTGGAGCGCG TGAACACGGA GATACACTTT 600 GTCACCAAAT GTGCCTTTCA GCCCCCCCCC AGCTGTCTTC GCTTCGTCCA GACCAACATC 660 TCCCGCCTCC TGCAGGAGAC CTCCGAGCAG CTGGTGGCGC TGAAGCCCTG GATCACTCGC 720 CAGAACTTCT CCCGGTGCCT GGAGCTGCAG TGTCAGCCCG ACTCCTCAAC CCTGGGCGGT 780 GGATCCGGAG GTGGCTCACG CGGAGGTAGT GGTACCCAGG ACTGCTCCTT cCAACACAGC 840 CCCATCTCCT CCGACTTCGC TGTCAAAATC CGTGAGCTGT CTGACTACCT GCTTCAA 897 (2)序列編號NO.· 174資料 : ⑴序列特性： (A) 長度：921鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 174 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CAATTCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CGAmCCCA GTCACCGTGG CCTCCAACCT GCAGGACGAG 480 GAGCTCTGCG GGGGCCTCTG GCGGCTGGTC CTGGCACAGC GCTGGATGGA GCGGCTCAAG 540 ACTGTCGCTG GGTCCAAGAT GCAAGGCTTG CTGGAGCGCG TGAACACGGA GATACACTTT 600 GTCACCAAAT GTGCCTTTCA GCCCCCCCCC AGCTGTCTTC GCTTCGTCCA GACCAACATC 660 TCCCGCCTCC TGCAGGAGAC CTCCGAGCAG CTGGTGGCGC TGAAGCCCTG GATCACTCGC 720 CAGAACTTCT CCCGGTGCCT GGAGCTGCAG TGTCAGCCCG ACTCCTCAAC CCTGGGCGGT 780 GGGTCAGGAG GTGGGTCAGG AGGTGGATCC GGAGGTGGCT CAGGGGGAGG TAGTGGTACC 840 CAGGACTGCT CCTTCCAACA CAGCCCCATC TCCTCCGACT TCGCTGTCAA AATCCGTGAG 900 CTGTCTGACT ACCTGCTTCA A 921 (2)序列編號NO: 175資料： (i)序列特性： (A) 長度·· 869鹼基對 (B) 形式：核酸 (C) 股數：單 O:\92\92747.DOC -96- 200413407 (D)拓撲結構：線形 (xi)序列描述：序列編號NO: 175 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CAATTCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACG1TC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CGCCTCCAAC CTGCAGGACG AGGAGCTCTG CGGGGGCCTC 480 TGGCGGCTGG TCCTGGCACA GCGCTGGATG GAGCGGCTCA AGACTGTCGC TGGGTCCAAG 540 ATGCAAGGCT TGCTGGAGCG CGTGAACACG GAGATACACT TTGTCACCAA ATGTGCdTT 600 CAGCCCCCCC CCAGCTGTCT TCGCTTCGTC CAGACCAACA TCTCCCGCCT CCTGCAGGAG 660 ACCTCCGAGC AGCTGGTGGC GCTGAAGCCC TGGATCACTC GCCAGAACTT CTCCCGGTGC 720 CTGGAGCTGC AGTGTCAGCC CGACTCCTCA ACCCTGGGCG GTGGATCCGG AGGTACTGCT 780 CCITCCAACA CAGCCCCATC TCCTCCGACT TCGCTGTCAA AATCCGTGAG CTGTCTGACT 840 ACCTGCTTCA AGATTACCCA GTCACCGTG 869 (2)序列編號NO: 176資料： ⑴序列特性： (A) 長度：872鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 176 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 nGCTGGACC CGAACAACCT CAATTCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 tatctgg™ CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CGCCTCCAAC CTGCAGGACG AGGAGCTCTG CGGGGGCCTC 480 TGGCGGCTGG TCCTGGCACA GCGCTGGATG GAGCGGCTCA AGACTGTCGC TGGGTCCAAG 540 ATGCAAGGCT TGCTGGAGCG CGTGAACACG GAGATACACT TTGTCACCAA ATGTGCCTTT 600 CAGCCCCCCC CCAGCTGTCT TCGCTTCGTC CAGACCAACA TCTCCCGCCT CCTGCAGGAG 660 ACCTCCGAGC AGCTGGTGGC GCTGAAGCCC TGGATCACTC GCCAGAACTT CTCCCGGTGC 720 CTGGAGCTGC AGTGTCAGCC CGACTCCTCA ACCCTGGGCG GTGGATCCGG AGGTGGCACT 780 GCTCCTTCCA ACACAGCCCC ATCTCCTCCG ACTTCGCTGT CAAAATCCGT GAGCTGTCTG 840 ACTACCTGCT TCAAGATTAC CCAGTCACCG TG 872 (2)序列編號NO: 177資料： (i)序列特性： O:\92\92747.DOC 97- 200413407 (A) 長度：890鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 177 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CAATTCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTMGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTM TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CGCCTCCAAC CTGCAGGACG AGGAGCTCTG CGGGGGCCTC 480 TGGCGGCTGG TCCTGGCACA GCGCTGGATG GAGCGGCTCA AGACTGTGGC TGGGTCCAAG 540 ATGCAAGGCT TGCTGGAGCG CGTGAACACG GAGATACACT TTGTCACCAA ATGTGCCTTT 600 CAGCCCCCCC CCAGCTGTCT TCGCTTCGTC CAGACCAACA TCTCCCGCCT CCTGCAGGAG 660 ACCTCCGAGC AGCTGGTGGC GCTGAAGCCC TGGATCACTC GCCAGAACTT CTCCCGGTGC 720 CTGGAGCTGC AGTGTCAGCC CGACTCCTCA ACCCTGGGCG GTGGATCCGG AGGTGGCTCA 780 GGGGGAGGTA GTGGTACTGC TCCTTCCAAC ACAGCCCCAT CTCCTCCGAC TTCGCTGTCA 840 AAATCCGTGA GCTGTCTGAC TACCTGCTTC AAGATTACCC AGTCACCGTG 890 (2)序列編號NO: 178資料： (i)序列特性： (A) 長度：917鹼基對 (B) 形式：核酸 (C) 股數：單 (D )拓撲結構·線形 (xi)序列描述：序列編號NO: 178 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT. CAATTCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTMGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTM TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CGCCTCCAAC CTGCAGGACG AGGAGCTCTG CGGGGGCCTC 480 TGGCGGCTGG TCCTGGCACA GCGCTGGATG GAGCGGCTCA AGACTGTCGC TGGGTCCAAC 540 ATGCAAGGCT TGCTGGAGCG CGTGAACACG GAGATACACT TTGTCACCAA ATGTGCCnT 600 CAGCCCCCCC CCAGCTGTCT TCGCTTCGTC CAGACCAACA TCTCCCGCCT CCTGCAGGAG 660 ACCTCCGAGC AGCTGGTGGC GCTGAAGCCC TGGATCACTC GCCAGAACTT CTCCCGGTGC 720 CTGGAGCTGC AGTGTCAGCC CGACTCCTCA ACCCTGGGCG GTGGGTCAGG AGGTGGGTCA 780 GGAGGTGGAT CCGGAGGTGG CTCAGGGGGA GGTAGTGGTA GGACTGCTCC TTCCAACACA 840 O:\92\92747.DOC -98- 200413407 GCCCCATCTC CTCCGACTTC GCTGTCAAAA TCCGTGAGCT GTCTGACTAC CTGCTTCAAG 900 ATTACCCAGT CACCGTG 917 (2)序列編號NO: 179資料 • (i)序列特性： (A)長度：876鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 179 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTCGACC CGAACAACCT CAATTCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACITAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CGTCGCTGGG TCCAAGATGC AAGGCTTGCT GGAGCGCGTG 480 AACACGGAGA TACACTTTGT CACCAAATGT GCCTTTCAGC CCCCCCCCAG CTGTCTTCGC 540 TTCGTCCAGA CCAACATCTC CCGCCTCCTG CAGGAGACCT CCGAGCAGCT GGTGGCGCTG 600 AAGCCCTGGA TCACTCGCCA GAACTTCTCC CGGTGCCTGG AGCTGCAGTG TCAGCCCGAC 660 TCCTCAACCC TGGGCGGTGG ATCCGGAGGT ACCCAGGACT GCTCCTTCCA ACACAGCCCC 720 ATCTCCTCCG ACTTCGCTGT CAAAATCCGT GAGCTGTCTG ACTACCTGCT TCAAGAmC 780 CCAGTCACCG TGGCCTCCAA CCTGCAGGAC GAGGAGCTCT GCGGC5GGCCT CTGGCGGCTG 840 GTCCTGGCAC AGCGCTGGAT GGAGCGGCTC AAGACT 876 (2)序列編號NO: 180資料 • (i)序列特性： (A)長度：879鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 180 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CAAnCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 tatctgg™ CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 O:\92\92747.DOC -99- 200413407 CATAAATCTC CAAACATGGC CGTCGCTGGG TCCAAGATGC AAGGCTTGCT GGAGCGCGTG AACACGGAGA TACACTTTGT CACCAAATGT GCCTTTCAGC CCCCCCCCAG CTGTCTTCGC TTCGTCCAGA CCAACATCTC CCGCCTCCTG CAGGAGACCT CCGAGCAGCT GGTGGCGCTG AAGCCCTGGA TCACTCGCCA GAACTTCTCC CGGTGCCTGG AGCTGCAGTG TCAGCCCGAC TCCTCAACCC TGGGCGGTGG ATCCGGAGGT GGCACCCAGG ACTGCTCCTT CCAACACAGC CCCATCTCCT CCGACITCGC TGTCAAAATC CGTGAGCTGT CTGACTACCT GCTTCAAGAT TACCCAGTCA CCGTGGCCTC CAACCTGCAG GACGAGGAGC TCTGCGGGGG CCTCTGGCGG CTGGTCCTGG CACAGCGCTG GATGGAGCGG CTCAAGACT (2)序列編號NO: 1 8 1資料 ! ⑴序列特性： (A) 長度：897鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO·. 181 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT TTGCTGGACC CGAACAACCT CMTTCTGM GACATGGATA TCCTGATGGA ACGAAACCTT CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT CGACATCCAA TCATCATCAA GCCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT CATAAATCTC CAAACATGGC CGTCGCTGGG TCCAAGATGC AAGGCTTGCT GGAGCGCGTG AACACGGAGA TACACTTTGT CACCAAATGT GCCTTTCAGC CCCCCCCCAG CTGTCTTCGC TTCGTCCAGA CCAACATCTC CCGCCTCCTG CAGGAGACCT CCGAGCAGCT GGTGGCGCTG AAGCCCTGGA TCACTCGCCA GAACTTCTCC CGGTGCCTGG AGCTGCAGTG TCAGCCCGAC TCCTCAACCC TGGGCGGTGG ATCCGGAGGT GGCTCAGGGG GAGGTAGTGG TACCCAGGAC TGCTCCTTCC AACACAGCCC CATCTCCTCC GACTTCGCTG TCAAAATCCG TGAGCTGTCT GACTACCTGC TTCAAGATTA CCCAGTCACC GTGGCCTCCA ACCTGCAGGA CGAGGAGCTC TGCGGGGGCC TCTGGCGGCT GGTCCTGGCA CAGCGCTGGA TGGAGCGGCT CAAGACT (2)序列編號NO: 182資料 ·· ⑴序列特性： (A) 長度：921鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 182

GCTAACTCCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT

O:\92\92747.DOC -100- 200413407 TTGCTGGACC CGAnCAACCT CaXTTCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTMGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CGTCGCTGGG TCCAAGATGC AAGGCTTGCT GGAGCGCGTG 480 AACACGGAGA TACACTTTGT CACCAAATGT GCCTTTCACC CCCCCCCCAG CTGTCTTCGC 540 TTCGTCCAGA CCAACATCTC CCGCCTCCTG CAGGAGACCT CCGAGCAGCT GGTGGCGCTG 600 AAGCCCTGGA TCACTCGCCA GAACTTCTCC CGGTGCCTGG AGCTGCAGTG TCAGCCCGAC 660 TCCTCAACCC TGGGCGGTGG GTCAGGAGGT GGGTCAGGAG GTGGATCCGG AGGTGGCTCA 720 GGGGGAGGTA GTGGTACCCA GGACTGCTCC TTCCAACACA GCCCCATCTC CTCCGACITC 780 GCTGTCAAAA TCCGTGAGCT GTCTGACTAC CTGCITCAAG ATTACCCAGT CACCGTGGCC 840 TCCAACCTGC AGGACGAGGA GCTCTGCGGG GGCCTCTGGC GGCTGGTCCT GGCACAGCGC 900 TGGATGGAGC GGCTCAAGAC T 921 (2)序列編號NO: 183資料： (i)序列特性： (A) 長度：876鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 183 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CMITCTGM GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTMGG GCTGTCAAGC ACTTAGAAAA TCCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CCGCTTCGTC CAGACCAACA TCTCCCCjCCT CCTGCAGGAG 480 ACCTCCGAGC AGCTGGTGGC GCTGAAGCCC TGGATCACTC GCCAGAACTT CTCCCGGTGC 540 CTGGAGCTGC AGTGTCAGCC CGACTCCTCA ACCCTGGGCG GTGGATCCGG AGGTACCCAG 600 GACTGCTCCT TCCAACACAG CCCCATCTCC TCCGACITCG CTGTCAAAAT CCGTGAGCTG 660 TCTGACTACC TGCTTCAAGA TTACCCAGTC ACCGTGGCCT CCAACCTGCA GGACGAGGAG 720 CTCTGCGGGG GCCTCTGGCG GCTGGTCCTG GCACAGCGCT GGATGGAGCG GCTCAAGACT 780 GTCGCTGGGT CCAAGATGCA AGGCTTGCTG GAGCGCGTGA ACACGGAGAT ACACTTTGTC 840 ACCAAATGTG CCTITCAGCC CCCCCCCAGC TGTCTT 876 (2)序列編號NO: 184資料： (i)序列特性· (A) 長度：879鹼基對 (B) 形式：核酸 O:\92\92747.DOC -101- 200413407 (c)股數：單 (D)拓撲結構：線形 (xi)序列描述：序列編號NO·. 184 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CAATTCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCITGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CCGCTTCGTC CAGACCAACA TCTCCCGCCT CCTGCAGGAG 480 ACCTCCGAGC AGCTGGTGGC GCTGAAGCCC TGGATCACTC GCCAGAACTT CTCCCGGTGC 540 CTGGAGCTGC AGTGTCAGCC CGACTCCTCA ACCCTGGGCG GTGGATCCGG AGGTGGCACC 600 CAGGACTGCT CCTTCCAACA CAGCCCCATC TCCTCCGACT TCGCTGTCAA AATCCGTGAG 660 CTGTCTGACT ACCTGCTTCA AGAmCCCA GTCACCGTGG CCTCCAACCT GCAGGACGAG 720 GAGCTCTGCG GGGGCCTCTG GCGGCTGGTC CTGGCACAGC GCTGGATGGA GCGGCTCAAG 780 ACTGTCGCTG GGTCCAAGAT GCAAGGCTTG CTGGAGCGCG TCAACACGGA GATACACTTT 840 GTCACCAAAT GTGCCTTTCA GCCCCCCCCC AGCTGTCTT 879 (2)序列編號NO·· 185資料 * ⑴序列特性： (A) 長度：897鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 185 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CAATTCTGAS GACATGGATA TCCTGATGGA ACGAAACCIT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC cCGCTTCGTC CAGACCAACA TCTCCCGCCT CCTGCAGGAG 4S0 ACCTCCGAGC AGCTGGTGGC GCTGAAGCCC TGGATCACTC GCCAGAACTT CTCCCGGTGC 540 CTGGAGCTGC AGTGTCAGCC CGACTCCTCA ACCCTGGGCG GTGGATCCGG AGGTGGCTCA 600 GGGGGAGGTA GTGGTACCCA GGACTGCTCC TTCCAACACA GCCCCATCTC CTCCGACTTC 660 GCTGTCAAAA TCCGTGAGCT GTCTGACTAC CTGCTTCAAG AmCCCAGT CACCGTGGCC 720 TCCAACCTGC AGGACGAGGA GCTCTGCGGG GGCCTCTGGC GGCTGGTCCT GGCACAGCGC 780 TGGATGGAGC GGCTCAAGAC TGTCGCTGGG TCCAAGATGC AAGGCTTGCT GGAGCGCGTG 840 AACACGGAGA TACACTTTGT CACCAAATGT GCCTTTCAGC CCCCCCCCAG CTGTCTT 897 (2)序列編號NO: 186資料： O:\92\92747.DOC 102- 200413407 ⑴序列特性： (A) 長度：921鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 186 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CAATTCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA nCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC cCGCTTCGTC CAGACCAACA TCTCCCGCCT cCTGCAGGAG 480 ACCTCCGAGC AGCTGGTGGC GCTGAAGCCC TGGATCACTC GCCAGAACTT CTCCCGGTGC 540 CTGGAGCTGC AGTGTCAGCC CGACTCCTCA ACCCTGGGCG GTGGGTCAGG AGGTGGGTCA 600 GGAGGTGGAT CCGGAGGTGG CTCAGGGGGA GGTAGTGGTA CCCAGGACTG CTCCITCCAA 660 CACAGCCCCA TCTCCTCCGA CITCGCTGTC AAAATCCGTG AGCTGTCTGA CTACCTGCTT 720 CAAGATTACC CAGTCACCGT GGCCTCCAAC CTGCAGGACG AGGAGCTCTG CGGGGGCCTC 780 TGGCGGCTGG TCCTGGCACA GCGCTGGATG GAGCGGCTCA AGACTGTCGC TGGGTCCAAG 840 ATGCAAGGCT TGCTGGAGCG CGTGAACACG GAGATACACT TTGTCACCAA ATGTGCCTTT 900 CAGCCCCCCC CCAGCTGTCT T 921 (2)序列編號NO: 187資料： (i)序列特性· (A) 長度：876鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 187 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CAATTCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTM TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAAGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CACCAACATC TCCCGCCTCC TGCAGGAGAC CTCCGAGCAG 480 CTGGTGGCGC TGAAGCCCTG GATCACTCGC CAGAACTTCT CCCGGTGCCT GGAGCTGCAG 540 TGTCAGCCCG ACTCCTCAAC CCTGGGCGGT GGATCCGGAG GTACCCAGGA CTGCTCCTTC 600 CAACACAGCC CCATCTCCTC CGACTTCGCT GTCAAAATCC GTGAGCTGTC TGACTACCTG 660 O:\92\92747.DOC -103- 200413407 CTTCAAGATT ACCCAGTCAC CGTGGCCTCC AACCTGCAGG ACGAGGAGCT CTGCGGGGGC 720 CTCTGGCGGC TGGTCCTGGC ACAGCGCTGG ATGGAGCGGC TCAAGACTGT CGCTGGGTCC 780 AAGATGCAAG GCTTGCTGGA GCGCGTGAAC ACGGAGATAC ACTTTGTCAC CAAATGTGCC 840 TTTCAGCCCC CCCCCAGCTG TCTTCGCTTC GTCCAG 876 (2)序列編號NO: 188資料 • ⑴序列特性： (A)長度：879鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述··序列編號NO: 188 # GCTAACTGCT CTATAATGAT CGATGMm ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CMTTCTGM GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAAGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CACCAACATC TCCCGCCTCC TGCAGGAGAC CTCCGAGCAG 480 CTCjGTGGCGC TGAAGCCCTG GATCACTCGC CAGAACTTCT CCCC3GTGCCT GGAGCTGCAG 540 TGTCAGCCCG ACTCCTCAAC CCTGGGCGGT GGATCCGGAG GTGGCACCCA GGACTGCTCC 600 TTCCAACACA GCCCCATCTC CTCCGACTTC GCTGTCAAAA TCCGTGAGCT GTCTGACTAC 660 CTGCTTCAAG ATTACCCACT CACCGTGGCC TCCAACCTGC AGGACGAGGA GCTCTGCGGG 720 GGCCTCTGGC GGCTGGTCCT GGCACAGCGC TGGATGGAGC GGCTCAAGAC TGTCGCTGGG 780 TCCAAGATGC AAGGCTTGCT GGAGCGCGTG AACACGGAGA TACACTTTGT CACCAAATGT 840 GCCITTCAGC CCCCCCCCAG CTGTCTTCGC TTCGTCCAG 879 (2)序列編號NO: 189資料：

⑴序列特性： (A) 長度：897鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 189 GCTAACTGCT CTATAATGAT CGATGAAm ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CAATTCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 O:\92\92747.DOC -104- 200413407 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAAGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CACCAACATC TCCCGCCTCC TGCAGGAGAC CTCCGAGCAG 480 CTGGTGGCGC TGAAGCCCTG GATCACTCGC CAGAACTTCT CCCGGTGCCT GGAGCTGCAG 540 TGTCAGCCCG ACTCCTCAAC CCTGGGCGGT GGATCCGGAG GTGGCTCAGG GGGAGGTAGT 600 GGTACCCAGG ACTGCTCCTT CCAACACAGC CCCATCTCCT CCGACTTCGC TGTCAAAATC 660 CGTGAGCTGT CTGACTACCT GCTTCAAGAT TACCCAGTCA CCGTGGCCTC CAACCTGCAG 720 GACGAGGAGC TCTGCGGGGG CCTCTGGCGG CTGGTCCTGG CACAGCGCTG GATGGAGCGG 780 CTCAAGACTG TCGCTGGGTC CAAGATGCAA GGCTTGCTGG AGCGCGTGAA CACGGAGATA 840 CACTTTGTCA CCAAATGTGC CTTTCAGCCC CCCCCCAGCT GTCTTCGCTT CGTCCAG 897 (2)序列編號NO: 190資料： (i)序列特性· (A) 長度：921鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 190 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CAATTCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 tatctgg™ CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CACCAACATC TCCCGCCTCC TGCAGGAGAC CTCCGAGCAG 480 CTGGTGGCGC TGAAGCCCTG GATCACTCGC CAGAACTTCT CCCGGTGCCT GGAGCTGCAG 540 TGTCAGCCCG ACTCCTCAAC CCTGGGCGGT GGGTCAGGAG GTGGGTCAGG AGGTGGATCC 600 GGAGGTGGCT CAGGGGGAGG TAGTGGTACC CAGGACTGCT CCTTCCAACA CAGCCCCATC 660 TCCTCCGACT TCGCTGTCAA AATCCGTGAG CTGTCTGACT ACCTGCITCA AGATTACCCA 720 GTCACCGTGG CCTCCAACCT GCAGGACGAG GAGCTCTGCG GGGGCCTCTG GCGGCTGGTC 780 CTGGCACAGC GCTGGATGGA GCGGCTCAAG ACTGTCGCTG GGTCCAAGAT GCAAGGCTTG 840 CTGGAGCGCG TGAACACGGA GATACACTTT GTCACCAAAT GTGCCnTCA GCCCCCCCCC 900 AGCTGTCTTC GCTTCGTCCA G 921 (2)序列編號NO: 191資料： (i)序列特性： (A) 長度：2247鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構·線形 O:\92\92747.DOC -105- 200413407 (xi)序列描述：序列編號NO: 191

GGATCCACCA

ATGTCTACAA

GATTCATCAG

GGGTGTGCGT

GATGTATCTG

CTCTGGGTCT

GGAGTTGTTT

TTTATTCAGA

CTGCTTTACA

TGCATATCTG

GAAAGCTGTA

TTATTTGGGA

CTGTTCACAA

GTAGGGGAAC

ACCTGGGAAT

TCAACAAACA

GACACCGGAT

ATCGTAGAAA

TATGAAGAGT

ACCTTCTCTC

TCCAAGTTTT

GATGCCCAAT

GAAGCATCGG

TGGAAGAAGT

AATAGAAAGG

AGTGAAGCCA

TGTGAGACGA

ATCATCCTGG

CTCTmTGCA

AGCAGCCTGG

CTTGGCACGC

CCCTGGGAGT

GTGCTCCAGG

GATCAGGTCC

CTCCGCTGTG

GAGAACCTCT

GAGGACGACT

CATGGGATGG

TGAGCCGCCT

ATCAAGATCT

TGGGGAAGTC

TGAGACCCCA

CTTCCATCAC

nAAGCACAG

CCATGGTCAT

GTGAAGCTAC

CATTAAGAAG

AGAGCGTOC

AAGAAGAAAG

TGGACATAAG

TAGATCTAAA

CCTTATGGAT

TAGAAAACAA

GAACTATGAT

ACTACACTTG

AGGGATTTAT

TTTGTmTC

GAAAATCATT

GCAATCATAA

TTACCAAAAT

CAAGTCAGGC

GTTCAGACAA

CTAACAGAAA

TAAAAGGGTT

TCCTTTTAAA

GCCTGTTCGG

GCCCCAACAG

GCTCCTGGGT

CACCCATCAC

CCCATAACAG

GGGACCCAAG

TTTATGGGCA

ACTCCACTCA

GGTTCCAGGC

GTGTCTTTGG

AGGCGCTGGG

GCCCGTCCTG

GCCTGTGATC

ATCATCATAT

GAGCTCAGGG

ACTGCAAGTG

CTCCCTGAAT

TTTGAAAATG

CAATTACACA

ACCTTACTTT

AGAGCCGATC TCCAGomr

GTGCTGTGCC

TCAAACTCCT

AAGGTGCAAA

AGCACTCGAG

ACGGATTCTG

TTCCTCTTCA

AAATGCTACC

TGTCAGGTTT

TCCTTGTGAG

GCACCAGCCA

GTTCACGCTG

GTCCTGTITC

GTCTCCCAAC

AGTGTTTGGA

CCTGGTCAAG

CTCTCCAGGC

CCTCCTGCTG

GAAGAATCCC

GCCCACAATC

CAAGCTCACA

CTCAGAGACC

AGCAGTTTCC

GCTGCTGGGC

GCCCCTCTTG

CAGCCCCTTG

GCCACTGCTC

GAGCTTC

CTCCTGCTCC

AAGTGTGTTT

CCCATGGTAT

ACAGTGTACG

CTGGTCGATG

TGCCAGCCAC

ACAGAAACCC

ATATTGTTTA

AGAAAAATGG

GTGGAATGGG

GTTAAAAAGG

AGAAATGAAC

CAGACCACAT

GCTGTTCATG

GAGGGCAACT

TTTGCmTG

AAGCATCCCA

AATTCAAGTG

AAAGCCTACC

CAAAAGGGTC

GGAGAATATA

AATATAAGAA

TCGGATGGAT

TGCACAGAAG

CAGTGGGTGT

TGCTGTGCAT

CCCTTCCCTT

TTGCTCACCT

CTCTGGCCAA

ATGGAGGAGG

GTGCTGGAGG

TGTGGCCTCC

ACCCAGCCCC

AGCCCCACAA

GCGOjCCTCA

GGGACCCTGG

AACTTCCCCC

AACTCCTGGT

TAATCAATCA

CAGAATCCCC

AAGCTGCCGC

CCCCAGGGAA

ATTTTGATTT

AAGCTGGAGA

CAGTGAGTAT

AAAACCAGGA

TGCTTTGCGA

AGGAAAAAGT

TGGGCAGGGA

TGCCACAATT

TGAACCATGG

ACTTTGAGAT

TATCATCAGT

GTCAATCAGC

AAGATTATGA

CACAAATCAG

TTGATAACGG

TATTCCATGC

GGAAACCTCA

ACCCAmCC

AGATCACAGA

CGAGCAGTAC

ACAATTCCCT

TCATCCAAGA

GCCTCTGTGG

GTGTCCCAGA

ATGCCTTCCA

AGGATGAAAA

CCACTCTGGT

AATCCCAGTC

GCCCAGGGCC

CCCCCAGCCC

TAACCCCAGC

TCCTGCAGGG

CCGCCCCGCC

TAAGAACAAT

GGAAGACCTC

TGTGGAAGTG

CATTTCCTGT

ACAAAACAGA

ATACCTACTT

AAGAAATACC

CGCCCTGGTC

TTCACAGGGG

GCTTCATGAA

ATGCACCAGG

ATnCTTAAA

ATTCGGGCTC

GAGTACCTAT

GGCAAGAAAC

TTTGGTTACC

AATTGACCAA

ATGTACGTGG

ATACAGCATA

AGAAAATGAT

AGTGCTCGCA

ATCTTGGACC

AGGAGTCTGG

TCTAAACATG

TGGCACATCT

CAACGAATTC

AACTGCCTGG

CCCAGCTCAC

GCTGCCCGGC

GAAGCCGGTG

CCAGACCTAT

TGGCACCAGC

AGGGCACTAT

CAAGTCCTAT

CCCAAGCCAG

GATCCGGGTC 60 120 180 240 300 360 420 480 540 600 660 720 780 840 900 960 1020 1080 1140 1200 1260 1320 1380 1440 1500 1560 1620 1680 1740 1800 1860 1920 1980 2040 2100 2160 2220 2247 (2)序列編號NO: 192資料： (i)序列特性： (A) 長度：1047鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 200413407 (xi)序列描述：序列編號NO: 192 GCTACACCAT TGGGCCCTGC CAGCTCCCTG CCCCAGAGCT TCCTGCTCAA GTCTTTAGAG 60 CAAGTGAGAA AGATCCAGGG CGATGGCGCA GCGCTCCAGG AGAAGCTGTG TGCCACCTAC 120 AAGCTGTGCC ACCCCGAGGA GCTGGTGCTG CTCGGACACT CTCTGGGCAT CCCCTGGGCT 180 CCCCTGAGCT CCTGCCCCAG CCAGGCCCTG CAGCTGGCAG GCTGCTTGAG CCAACTCCAT 240 AGCGGCCTTT TCCTCTACCA GGGGCTCCTG CAGGCCCTGG AAGGGATATC CCCCGAGTTG 300 GGTCCCACCT TGGACACACT GCAGCTGGAC GTCGCCGACT mCCkCCkC CATCTGGCAG 360 CAGATGGAAG AACTGGGAAT GGCCCCTGCC CTGCAGCCCA CCCAGGGTGC CATGCCGGCC 420 TTCGCCTCTG CTTTCCAGCG CCGGGCAGGA GGGGTCCTGG TTGCTAGCCA TCTGCAGAGC 480 TTCCTGGAGG TGTCGTACCG CGTTCTACGC CACCTTGCGC AGCCCTACGT AGAGGGCGGT 540 GGAGGCTCCC CGGGTGAACC GTCTGGTCCA ATCTCTACTA TCAACCCGTC TCCTCCGTCT 600 AAAGAATCTC ATAAATCTCC AAACATGGCC ACCCAGGACT GCTCCTTCCA ACACAGCCCC 660 ATCTCCTCCG ACTTCGCTGT CAAAATCCGT GAGCTGTCTG ACTACCTGCT TCAAGAmC 720 CCAGTCACCG TGGCCTCCAA CCTGCAGGAC GAGGAGCTCT GCGGGGGCCT CTGC3CGGCTG 780 GTCCTGGCAC AGCGCTGGAT GGAGCGGCTC AAGACTGTCG CTGGGTCCAA GATGCAAGGC 840 TTGCTGGAGC GCGTGAACAC GGAGATACAC TTTGTCACCA AATGTGCCTT TCAGCCCCCC 900 CCCAGCTGTC TTCGCTTCGT CCAGACCAAC ATCTCCCGCC TCCTGCAGGA GACCTCCGAG 960 CAGCTGGTGG CGCTGAAGCC CTGGATCACT CGCCAGAACT TCTCCCGGTG CCTGGAGCTG 1020 CAGTGTCAGC CCGACTCCTC AACCCTG 1047 (2)序列編號NO: 193資料： (i)序列特性： (A) 長度：942鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 193 GCCACTCAGG ACTGCTCnT TCAACACAGC CCCATCTCCT CCGACTTCGC TGTCAAAATC 60 CGTGAGCTGT CTGACTACCT GCTTCAAGAT TACCCAGTCA CCGTGGCCTC CAACCTGCAG 120 GACGAGGAGC TCTGCGGGGG CCTCTGGCGG CTGGTCCTGG CACAGCGCTG GATGGAGCGG 180 CTCAAGACTG TCGCTGGGTC CAAGATGCAA GGCTTGCTGG AGCGCGTGAA CACGGAGATA 240 CACTTTGTCA CCAAATGTGC CTTTCAGCCC CCCCCCAGCT GTCTTCGCTT CGTCCAGACC 300 AACATCTCCC GCCTCCTGCA GGAGACCTCC GAGCAGCTGG TGGCGCTGAA GCCCTGGATC 360 ACTCGCCAGA ACTTCTCCCG GTGCCTGGAG CTGCAGTGTC AGCCCGACTC CTCAACCCTG 420 TACGTAGAGG GCGGTGGAGG CTCCCCGGGT GAACCGTCTG GTCCAATCTC TACTATCAAC 480 CCGTCTCCTC CGTCTAAAGA ATCTCATAAA TCTCCAAACA TGGCTACCCA GGACTGCTCC 540 TYCCkkCkCk GCCCCATCTC CTCCGACITC GCTGTCAAAA TCCGTGAGCT GTCTGACTAC 600 CTGCTTCAAG AmCCCAGT CACCGTGGCC TCCAACCTGC AGGACGAGGA GCTCTGCGGG 660 GGCCTCTGGC GGCTGGTCCT GGCACAGCGC TGGATGGAGC GGCTCAAGAC TGTCGCTGGG 720 TCCAAGATGC AAGGCTTGCT GGAGCGCGTG AACACGGAGA TACACTTTGT CACCAAATGT 780 GCCTTTCAGC CCCCCCCCAG CTGTCTTCGC TTCGTCCAGA CCAACATCTC CCGCCTCCTG 840 CAGGAGACCT CCGAGCAGCT GGTGGCGCTG AAGCCCTGGA TCACTCGCCA GAACTTCTCC 900 CGGTGCCTGG AGCTGCAGTG TCAGCCCGAC TCCTCAACCC TG 942 (2)序列編號NO: 194資料： O:\92\92747.DOC -107- 200413407 (i)序列特性· (A) 長度：1047鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 194 GCCACCCAGG ACTGCTCCTT TCAACACAGC CCCATCTCCT CCGACTTCGC TGTCAAAATC 60 CGTGAGCTGT CTGACTACCT GCTTCAAGAT TACCCAGTCA CCGTGGCCTC CAACCTGCAG 120 GACGAGGAGC TCTGCGGGGG CCTCTGGCGG CTGGTCCTGG CACAGCGCTG GATGGAGCGG 180 CTCAAGACTG TCGCTGGGTC CAAGATGCAA GGCTTGCTGG AGCGCGTGAA CACGGAGATA 240 CACTTTGTCA CCAAATGTGC CTTTCAGCCC CCCCCCAGCT GTCTTCGCTT CGTCCAGACC 300 AACATCTCCC GCCTCCTGCA GGAGACCTCC GAGCAGCTGG TGGCGCTGAA GCCATGGATC 360 ACTCGCCAGA ACTTCTCCCG GTGCCTGGAG CTGCAGTGTC AGCCCGACTC CTCAACCCTG 420 TACGTAGAGG GCGGTGGACG CTCCCCGGGT GAACCGTCTG GTCCAATCTC TACTATCAAC 480 CCGTCTCCTC CGTCTAAAGA ATCTCATAAA TCTCCAAACA TGGCTACACC AmGGCCCT 540 GCCAGCTCCC TGCCCCAGAG CTTCCTGCTC AAGTGCTTAG AGCAAGTGAG GAAGATCCAG 600 GGCGATGGCG CAGCGCTCCA GGAGAAGCTG TGTGCCACCT ACAAGCTGTG CCACCCCGAG 660 GAGCTGGTGC TGCTCGGACA CTCTCTGGGC ATCCCCTGGG CTCCCCTGAG CTCCTGCCCC 720 AGCCAGGCCC TGCAGCTGGC AGGCTGCTTG AGCCAACTCC ATAGCGGCCT TTTCCTCTAC 780 CAGGGGCTCC TGCAGGCCCT GGAAGGGATA TCCCCCGAGT TGGGTCCCAC CTTGGACACA 840 CTGCAGCTGG ACGTCGCCGA CTTTGCCACC ACCATCTGGC AGCAGATGGA AGAACTGGGA 900 ATGGCCCCTG CCCTGCAGCC CACCCAGGGT GCCATGCCGG CCTTCGCCTC TGCTTTCCAG 960 CGCCGGGCAG GAGGGGTCCT GGTTGCTAGC CATCTGCAGA GCTTCCTGGA GGTGTCGTAC 1020 CGCGTTTTAC GCCACCTTGC GCAGCCC 1047

(2)序列編號NO: 195資料： (i)序列特性： (A) 長度：1569鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 195 GCTACACCAT TGGGCCCTGC CAGCTCCCTG CCCCAGAGCT TCCTGCTCAA GTCTITAGAG 60 CAAGTGAGAA AGATCCAGGG CGATGGCGCA GCGCTCCAGG AGAAGCTGTG TGCCACCTAC 120 AAGCTGTGCC ACCCCGAGGA GCTGGTGCTG CTCGGACACT CTCTGGGCAT CCCCTGGGCT 180 CCCCTGAGCT CCTGCCCCAG CCAGGCCCTG CAGCTGGCAG GCTGCTTGAG CCAACTCCAT 240 AGCGGCCTTT TCCTCTACCA GGGGCTCCTG CAGGCCCTGG AAGGGATATC CCCCGAGTTG 300 GGTCCCACCT TGGACACACT GCAGCTGGAC GTCGCCGACT TTGCCACCAC CATCTGGCAG 360 CAGATGGAAG AACTGGGAAT GGCCCCTGCC CTGCAGCCCA CCCAGGGTGC CATGCCGGCC 420 TTCGCCTCTG CnTCCAGCG CCGGGCAGCA GGGGTCCTGG TTGCTAGCCA TCTGCAGAGC 480 TTCCTGGAGG TGTCGTACCG CGTTCTACGC CACCTTGCGC AGCCCTACGT AGAGGGCGGT 540 O:\92\92747.DOC -108- GGAGGCTCCC CGGGTGAACC GTCTGGTCCA ATCTCTACTA TCAACCCGTC TCCTCCGTCT 600 AAAGAATCTC ATAAATCTCC AAACATGGCC ACTCAGGACT GCTCTTTTCA ACACAGCCCC 660 ATCTCCTCCG ACTTCGCTGT CAAAATCCGT GAGCTGTCTG ACTACCTGCT TCAAGATTAC 720 CCAGTCACCG TGGCCTCCAA CCTGCAGGAC GAGGAGCTCT GCGGGGGCCT CTGGCGGCTG 780 GTCCTGGCAC AGCGCTGGAT GGAGCGGCTC AAGACTGTCG CTGGGTCCAA GATGCAACGC 840 TTGCTGGAGC GCGTGAACAC GGAGATACAC TTTGTCACCA AATGTGCCTT TCAGCCCCCC 900 CCCAGCTGTC TTCGCTTCGT CCAGACCAAC ATCTCCCGCC TCCTGCAGGA GACCTCCGAG 960 CAGCTGGTGG CGCTGAAGCC CTGGATCACT CGCCAGAACT TCTCCCGGTG CCTGGAGCTG 1020 CAGTGTCAGC CCGACTCCTC AACCCTGTAC GTAGAGGGCG GTGGAGGCTC CCCGGGTGAA 1080 CCGTCTGGTC CAATCTCTAC TATCAACCCG TCTCCTCCGT CTAAAGAATC TCATAAATCT 1140 CCAAACATGG CTACCCAGGA CTGCTCCTTC CAACACAGCC CCATCTCCTC CGACTTCGCT 1200 GTCAAAATCC GTGAGCTGTC TGACTACCTG CTTCAAGATT ACCCAGTCAC CGTGGCCTCC 1260 AACCTGCAGG ACGAGGAGCT CTGCGGGGGC CTCTGGCGGC TGGTCCTGGC ACAGCGCTGG 1320 ATGGAGCGGC TCAAGACTGT CGCTGGGTCC AAGATGCAnG GCTTGCTGGA GCGCGTGAAC 1380 ACGGAGATAC ACTTTGTCAC CAAATGTGCC TTTCAGCCCC CCCCCAGCTG TCTTCGCTTC 1440 GTCCAGACCA ACATCTCCCG CCTCCTGCAG GAGACCTCCG AGCAGCTGGT GGCGCTGAAG 1500 CCCTGGATCA CTCGCCAGAA CTTCTCCCGG TGCCTGGAGC TGCAGTGTCA GCCCGACTCC 1560 TCAACCCTG 1569 (2)序列編號NO: 196資料： (i)序列特性： (A) 長度：1380鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 196 GCTAACTGCT CTATAATGAT CGATGAAAW ATACATCACT TAAAGAGACC ACCTGCACCT 60 TTGCTGGACC CGAACAACCT CAATGACGAA GACGTCTCTA TCCTGATGGA CCGAAACCTT 120 CGACTTCCAA ACCTGGAGAG CTTCGTAAGG GCTGTCAAGA ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTOTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CACTCAGGAC TGCTCmrC AACACAGCCC CATCTCCTCC 480 GACITCGCTG TCAAAATCCG TGAGCTGTCT GACTACCTGC TTCAAGAm CCCAGTCACC 540 GTGGCCTCCA ACCTGCAGGA CGAGGAGCTC TGCGGGGGCC TCTGGCGGCT GGTCCTGGCA 600 CAGCGCTGGA TGGAGCGGCT CAAGACTGTC GCTGGGTCCA AGATGCAAGG CTTGCTGGAG 660 CGCGTGAACA CGGAGATACA CTTTGTCACC AAATGTGCCT TTCAGCCCCC CCCCAGCTGT 720 CTTCGCTTCG TCCAGACCAA CATCTCCCGC CTCCTGCAGG AGACCTCCGA GCAGCTGGTG 780 GCGCTGAAGC CCTGGATCAC TCGCCAGAAC TTCTCCCGGT GCCTGGAGCT GCAGTGTCAG 840 CCCGACTCCT CAACCCTGTA CGTAGAGGGC GGTGGAGGCT CCCCGGGTGA ACCGTCTGGT 900 CCAATCTCTA CTATCAACCC GTCTCCTCCG TCTAAAGAAT CTCATAAATC TCCAAACATG 960 GCTACCCAGG ACTGCTCCTT CCAACACAGC CCCATCTCCT CCGACTTCGC TGTCAAAATC 1020 CGTGAGCTGT CTGACTACCT GCTTCAAGAT TACCCAGTCA CCGTGGCCTC CAACCTGCAG 1080 GACGAGGAGC TCTGCGGGGG CCTCTGGCGG CTGGTCCTGG CACAGCGCTG GATGGAGCGG 1140 CTCAAGACTG TCGCTGGGTC CAAGATGCAA GGCTTGCTGG AGCGCGTGAA CACGGAGATA 1200 CACTTTGTCA CCAAATGTGC CTTTCAGCCC CCCCCCAGCT GTCTTCGCTT CGTCCAGACC 1260 O:\92\92747.DOC -109- 200413407

AACATCTCCC GCCTCCTGCA GGAGACCTCC GAGCAGCTGG TGGCGCTGAA GCCCTGGATC 1320 ACTCGCCAGA ACTTCTCCCG GTGCCTGGAG CTGCAGTGTC AGCCCGACTC CTCAACCCTG 1380 (2)序列編號NO: 197資料 (i)序列特性： (A)長度：1569鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (x〇序列描述：序列編號NO: 197 GCCACTCAGG ACTGCTCrrT TCAACACAGC CCCATCTCCT CCGACTTCGC TGTCAAAATC 60 CGTGAGCTGT CTGACTACCT GCTTCAAGAT TACCCAGTCA CCGTGGCCTC CAACCTGCAG 120 GACGAGGAGC TCTGCGC3GGG CCTCTGGCGG CTGGTCCTGG CACAGCGCTG GATGGAGCGG 180 CTCAAGACTG TCGCTGGGTC CAAGATGCAA GGCTTGCTGG AGCGCGTGAA CACGGAGATA 240 CACTTTGTCA CCAAATGTGC CTTTCAGCCC CCCCCCAGCT GTCTTCGCTT CGTCCAGACC 300 AACATCTCCC GCCTCCTGCA GGAGACCTCC GAGCAGCTGG TGGCGCTGAA GCCCTGGATC 360 ACTCGCCAGA ACTTCTCCCG GTGCCTGGAG CTGCAGTGTC AGCCCGACTC CTCAACCCTG

1569 420 TACGTAGAGG GCGGTGGAGG CTCCCCGGGT GAACCGTCTG GTCCAATCTC TACTATCAAC 480 CCGTCTCCTC CGTCTAAAGA ATCTCATAAA TCTCCAAACA TGGCTACACC ATTGGGCCCT 540 GCCAGCTCCC TGCCCCAGAG CTTCCTGCTC AAGTCTTTAG AGCAAGTGAG AAAGATCCAG 600 GGCGATGGCG CAGCGCTCCA GGAGAAGCTG TGTGCCACCT ACAAGCTGTG CCACCCCGAG 660 GAGCTGGTGC TGCTCGGACA CTCTCTGGGC ATCCCCTGGG CTCCCCTGAG CTCCTGCCCC 720 AGCCAGGCCC TGCAGCTGGC AGGCTGCTTG AGCCAACTCC ATAGCGGCCT TrTCCTCTAC 780 CAGGGGCTCC TGCAGGCCCT GGAAGGGATA TCCCCCGAGT TGGGTCCCAC CTTGGACACA 840 CTGCAGCTGG ACGTCGCCGA CTTTGCCACC ACCATCTGGC AGCAGATGGA AGAACTGGGA 900 ATGGCCCCTG CCCTGCAGCC CACCCAGGGT GCCATGCCGG CCTTCGCCTC TGCTTTCCAG 960 CGCCGGGCAG GAGGGGTCCT GGTTGCTAGC CATCTGCAGA GCTTCCTGGA GGTGTCGTAC 1020 CGCGTTCTAC GCCACCTTGC GCAGCCCTAC GTAGAGGGCG GTGGAGGCTC CCCGGGTGAA 1080 CCGTCTGGTC CAATCTCTAC TATCAACCCG TCTCCTCCGT CTAAAGAATC TCATAAATCT 1140 CCAAACATGG CTACCCAGGA CTGCrCCTTC CAACACAGCC CCATCTCCTC CGACTTCGCT 1200 GTCAAAATCC GTGAGCTGTC TGACTACCTG CTTCAAGAn ACCCAGTCAC CGTGGCCTCC 1260 AACCTGCAGG ACGAGGAGCT CTGCGGGGGC CTCTGGCGGC TGGTCCTGGC ACAGCGCTGG 1320 ATGGAGCGGC TCAAGACTGT CGCTGGGTCC AAGATGCAAG GCTTGCTGGA GCGCGTGAAC 1380 ACGGAGATAC ACTTTGTCAC CAAATGTGCC TTTCAGCCCC CCCCCAGCTG TCTTCGCTTC 1440 GTCCAGACCA ACATCTCCCG CCTCCTGCAG GAGACCTCCG AGCAGCTGGT GGCGCTGAAG 1500 CCCTGGATCA CTCGCCAGAA CTTCTCCCGG TGCCTGGAGC TGCAGTGTCA GCCCGACTCC 1560 TCAACCCTG 1569

(2)序列編號NO: 198資料： (i)序列特性： (A) 長度：1003鹼基對 (B) 形式：核酸 O:\92\92747.DOC -110- 200413407 (c)股數：單 (D)拓撲結構：線形

(xi)序列描述：序列編號NO: 198 GGCCACTCAG GACTGCTCTT TTCAACACAG CCCCATCTCC TCCGACTTCG CTGTCAAAAT 60 CCGTGAGCTG TCTGACTACC TGCTTCAAGA TTACCCAGTC ACCGTGGCCT CCAACCTGCA 120 GGACGAGGAG CTCTGCGGGG GCCTCTGGCG GCTGGTCCTG GCACAGCGCT GGATGGAGCG 180 GCTCAAGACT GTCGCTGGGT CCAAGATGCA AGGCTTGCTG GAGCGCGTGA ACACGGAGAT 240 ACACTTTGTC ACCAAATGTG CCTTTCAGCC CCCCCCCAGC TGTCTTCGCT TCGTCCAGAC 300 CAACATCTCC CGCCTCCTGC AGGAGACCTC CGAGCAGCTG GTGGCGCTGA AGCCCTGGAT 360 CACTCGCCAG AACTTCTCCC GGTGCCTGGA GCTGCAGTGT CAGCCCGACT CCTCAACCCT 420 GTACGTAGAG GGCGGTGGAG GCTCCCCGGG TGGTGCTTCT GGCGGCGGCT CCAACATGGC 480 TACACCATTG GGCCCTGCCA GCTCCCTGCC CCAGAGCTTC CTGCTCAAGT CTTTAGAGCA 540 AGTGAGAAAG ATCCAGGGCG ATGGCGCAGC GCTCCAGGAG AAGCTGTGTG CCACCTACAA 600 GCTGTGCCAC CCCGAGGAGC TGGTGCTGCT CGGACACTCT CTGGGCATCC CCTGGGCTCC 660 CCTGAGCTCC TGCCCCAGCC AGGCCCTGCA GCTGGCAGGC TGCTTGAGCC AACTCCATAG 720 CGGCCTTTTC CTCTACCAGG GGCTCCTGCA GGCCCTGGAA GGGATATCCC CCGAGTTGGG 780 TCCCACCTTG GACACACTGC AGCTGGACGT CGCCGACTTT GCCACCACCA TCTGGCAGCA 840 GATGGAAGAA CTGGGAATGG CCCCTGCCCT GCAGCCCACC CAGGGTGCCA TGCCGGCCTT 900 CGCCTCTGCT TTCCAGCGCC GGGCAGGAGG GGTCCTGGTT GCTAGCCATC TGCAGAGCTT 960 CCTGGAGGTG TCGTACCGCG TTCTACGCCA CCTTGCGCAG CCG 1003 (2)序列編號NO: 199資料 • (i)序列特性： (A)長度：888鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 199 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CAATTCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCITGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CGAmCCCA GTCACCGTGG CCTCCAACCT GCAGGACGAG 480 GAGCTCTGCG GGGGCCTCTG GCGGCTGGTC CTGGCACAGC GCTGGATGGA GCGGCTCAAG 540 ACTGTCGCTG GGTCCAAGAT GCAAGGCTTG CTGGAGCGCG TGAACACGGA GATACACTTT 600 GTCACCAAAT GTGCCTITCA GCCCCCCCCC AGCTGTCITC GCTTCGTCCA GACCAACATC 660 TCCCGCCTCC TGCAGGAGAC CTCCGAGCAG CTGGTGGCGC TGAAGCCCTG GATCACTCGC 720 CAGAACTTCT CCCGGTGCCT GGAGCTGCAG TGTCAGCCCG ACTCCTCAAC CCTGGGCGGT 780 GGGTCAGGAG GTGGATCCGG AGGTACCCAG GACTGCTCCT TCCAACACAG CCCCATCTCC 840 TCCGACTTCG CTGTCAAAAT CCGTGAGCTG TCTGACTACC TGCTTCAA 888 O:\92\92747.DOC -111 200413407 (2)序列編號NO: 200資料： ⑴序列特性： (A) 長度：903鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 200 GCTAACTGCT CTATAATGAT CGATGAMH ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CAATTCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTMGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCITCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CGATTACCCA GTCACCGTGG CCTCCAACCT GCAGGACGAG 480 GAGCTCTGCG GGGGCCTCTG GCGGCTGGTC CTGGCACAGC GCTGGATGGA GCGGCTCAAG 540 ACTGTCGCTG GGTCCAAGAT GCAAGGCTTG CTGGAGCGCG TGAACACGGA GATACACTTT 600 GTCACCAAAT GTGCCTTTCA GCCCCCCCCC AGCTGTCTTC GCTTCGTCCA GACCAACATC 660 TCCCGCCTCC TGCAGGAGAC CTCCGAGCAG CTGGTGGCGC TGAAGCCCTG GATCACTCGC 720 CAGAACTTCT CCCGGTGCCT GGAGCTGCAG TGTCAGCCCG ACTCCTCAAC CCTGGGCGGT 780 GGGTCAGGAG GTGGGTCAGG AGGTGGATCC GGAGGTGGCA CCCAGGACTG CTCCTTCCAA 840 CACAGCCCCA TCTCCTCCGA CTTCGCTGTC AAAATCCGTG AGCTGTCTGA CTACCTGCTr 900 CAA 903 (2)序列編號NO: 201資料： (i)序列特性： (A)長度：888鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 201 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CMTTCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCITCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAS TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGCTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CGCCTCCAAC CTGCAGGACG AGGAGCTCTG CGGGGGCCTC 480 O:\92\92747.DOC -112- 200413407 TGGCGGCTGG TCCTGGCACA GCGCTGGATG GAGCGGCTCA AGACTGTCGC TGGGTCCAAG 540 ATGCAAGGCT TGCTGGAGCG CGTGAACACG GAGATACACT TTGTCACCAA ATGTGCCTTT 600 CAGCCCCCCC CCAGCTGTCT TCGCTTCGTC CAGACCAACA TCTCCCGCCT CCTGCAGGAG 660 ACCTCCGAGC AGCTGGTGGC GCTGAAGCCC TGGATCACTC GCCAGAACTT CTCCCGGTGC 720 CTGGAGCTGC AGTGTCAGCC CGACTCCTCA ACCCTGGGCG GTGGGTCAGG AGGTGGATCC 780 GGAGGTACCC AGGACTGCTC CTTCCAACAC AGCCCCATCT CCTCCGACTT CGCTGTCAAA 840 ATCCGTGAGC TGTCTGACTA CCTGCTTCAA GATTACCCAG TCACCGTG 888 (2)序列編號NO: 202資料： (i)序列特性： (A)長度：903鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO.· 202 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CMTTCTGM GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGaXGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CGCCTCCAAC CTGCAGGACG AGGAGCTCTG CGGGGGCCTC 480 TGGCGGCTGG TCCTGGCACA GCGCTGGATG GAGCGGCTCA AGACTGTCGC TGGGTCCAAG 540 ATGCAAGGCT TGCTGGAGCG CGTGAACACG GAGATACACT TTGTCACCAA ATGTGCCTTT 600 CAGCCCCCCC CCAGCTGTCT TCGCTTCGTC CAGACCAACA TCTCCCGCCT CCTGCAGGAG 660 ACCTCCGAGC AGCTGGTGGC GCTGAAGCCC TGGATCACTC GCCAGAACTT CTCCCGGTGC 720 CTGGAGCTGC AGTGTCAGCC CGACTCCTCA ACCCTGGGCG GTGGGTCAGG AGGTGGGTCA 780 GGAGGTGGAT CCGGAGGTGG CACCCAGGAC TGCTCCTTCC AACACAGCCC CATCTCCTCC 840 GACrrCGCTG TCAAAATCCG TGAGCTGTCT GACTACCTGC TTCAAGATTA CCCAGTCACC 900 GTG 903 (2)序列編號NO: 203資料： (i)序列特性： (A)長度：888鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 203 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60

O:\92\92747.DOC -113- 200413407 TTGCTGGACC CGAACAACCT CAATTCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGC5GAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CGTCGCTGGG TCCAAGATGC AAGGCTTGCT GGAGCGCGTG 480 AACACGGAGA TACACTTTGT CACCAAATGT GCCTTTCAGC CCCCCCCCAG CTGTCTTCGC 540 TTCGTCCAGA CCAACATCTC CCGCCTCCTG CAGGAGACCT CCGAGCAGCT GGTGGCGCTG 600 AAGCCCTGGA TCACTCGCCA GAACTTCTCC CGGTGCCTGG AGCTGCAGTG TCAGCCCGAC 660 TCCTCAACCC TGGGCGGTGG GTCAGGAGGT GGATCCGGAG GTACCCAGGA CTGCTCCTTC 720 CAACACAGCC CCATCTCCTC CGACTTCGCT GTCAAAATCC GTGAGCTGTC TGACTACCTG 780 CTTCAAGAn ACCCAGTCAC CGTGGCCTCC AACCTGCAGG ACGAGGAGCT CTGCGGGGGC 840 CTCTGGCGGC TGGTCCTGGC ACAGCGCTGG ATGGAGCGGC TCAAGACT 888 (2)序列編號NO: 204資料： ⑴序列特性：

(A) 長度：903鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 204 GCTAACTGCT CTATAATGAT CGkTGkAm ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CAATTCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CGTCGCTGGG TCCAAGATGC AAGGCTTGCT GGAGCGCGTG 480 AACACGGAGA TACACTTTGT CACCAAATGT GCCTITCAGC CCCCCCCCAG CTGTCTTCGC 540 TTCGTCCAGA CCAACATCTC CCGCCTCCTG CAGGAGACCT CCGAGCAGCT GGTGGCGCTG 600 AAGCCCTGGA TCACTCGCCA GAACTTCTCC CGGTGCCTGG AGCTGCAGTG TCAGCCCGAC 660 TCCTCAACCC TGGGCGGTGG GTCAGGAGGT GGGTCAGGAG GTGGATCCGG AGGTGGCACC 720 CAGGACTGCT CCTTCCAACA CAGCCCCATC TCCTCCGACT TCGCTGTCAA AATCCGTGAG 780 CTGTCTGACT ACCTGCTTCA AGATTACCCA GTCACCGTGG CCTCCAACCT GCAGGACGAG 840 GAGCTCTGCG GGGGCCTCTG GCGGCTGGTC CTGGCACAGC GCTGGATGGA GCGGCTCAAG 900 ACT 903 (2)序列編號NO: 205資料：

⑴序列特性： (A) 長度：888鹼基對 (B) 形式：核酸 O:\92\92747.DOC 114- 200413407 (c)股數：單 (D)拓撲結構：線形

(xi)序列描述：序列編號NO: 205 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CAATTCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACITAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CCGCTTCGTC CAGACCAACA TCTCCCGCCT CCTGCAGGAG 480 ACCTCCGAGC AGCTGGTGGC GCTGAAGCCC TGGATCACTC GCCAGAACTT CTCCCGGTGC 540 CTGGAGCTGC AGTGTCAGCC CGACTCCTCA ACCCTGGGCG GTGGGTCAGG AGGTGGATCC 600 GGAGGTACCC AGGACTGCTC CTTCCAACAC AGCCCCATCT CCTCCGACTT CGCTGTCAAA 660 ATCCGTGAGC TGTCTGACTA CCTGCTTCAA GATTACCCAG TCACCGTGGC CTCCAACCTG 720 CAGGACGAGG AGCTCTGCGG GGGCCTCTGG CGGCTGGTCC TGGCACAGCG CTGGATGGAG 780 CGGCTCAAGA CTGTCGCTGG GTCCAAGATG CAAGGCITGC TGGAGCGCGT GAACACGGAG 840 ATACACTTTG TCACCAAATG TGCCTTTCAG CCCCCCCCCA GCTGTCTT 888 (2)序列編號NO: 206資料： (i)序列特性： (A)長度：903鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 206 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CAAnCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAn TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CCGCTTCGTC CAGACCAACA TCTCCCGCCT CCTGCAGGAG 480 ACCTCCGAGC AGCTGGTGGC GCTGAAGCCC TGGATCACTC GCCAGAACTT CTCCCGGTGC 540 CTGGAGCTGC AGTGTCAGCC CGACTCCTCA ACCCTGGGCG GTGGGTCAGG AGGTGGGTCA 600 GGAGGTGGAT CCGGAGGTGG CACCCAGGAC TGCTCCTTCC AACACAGCCC CATCTCCTCC 660 GACTTCGCTG TCAAAATCCG TGAGCTGTCT GACTACCTGC TTCAAGATTA CCCAGTCACC 720 GTGGCCTCCA ACCTGCAGGA CGAGGAGCTC TGCGGGGGCC TCTGGCGGCT GGTCCTGGCA 780 CAGCGCTGGA TGGAGCGGCT CAAGACTGTC GCTGGGTCCA AGATGCAAGG CTTGCTGGAG 840 CGCGTGAACA CGGAGATACA CTTTGTCACC AAATGTGCCT TTCAGCCCCC CCCCAGCTGT 900 CTT 903 O:\92\92747.DOC -115 200413407 (2)序列編號NO: 207資料： (i)序列特性： (A) 長度：888鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 207 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CAATTCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTMGG GCTGTCAAGC ACITAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAAGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CACCAACATC TCCCGCCTCC TGCAGGAGAC CTCCGAGCAG 480 CTGGTGGCGC TGAAGCCCTG GATCACTCGC CAGAACTTCT CCCGGTGCCT GGAGCTGCAG 540 TGTCAGCCCG ACTCCTCAAC CCTGGGCGGT GGGTCAGGAG GTGGATCCGG AGGTACCCAG 600 GACTGCTCCT TCCAACACAG CCCCATCTCC TCCGACTTCG CTGTCAAAAT CCGTGAGCTG 660 TCTGACTACC TGCTTCAAGA mCCCAGTC ACCGTGGCCT CCAACCTGCA GGACGAGGAG 720 CTCTGCGGGG GCCTCTGGCG GCTGGTCCTG GCACAGCGCT GGATGGAGCG GCTCAAGACT 780 GTCGCTGGGT CCAAGATGCA AGGCTTGCTG GAGCGCGTGA ACACGGAGAT ACACTTTGTC 840 ACCAAATGTG CCTTTCAGCC CCCCCCCAGC TGTCTTCGCT TCGTCCAG 888 (2)序列編號NO: 208資料： (i)序列特性： (A)長度：903鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 208 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CAATTCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTMGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CACCAACATC TCCCGCCTCC TGCAGGAGAC CTCCGAGCAG 480 CTGGTGGCGC TGAAGCCCTG GATCACTCGC CAGAACTTCT CCCGGTGCCT GGAGCTGCAG 540 TGTCAGCCCG ACTCCTCAAC CCTGGGCGGT GGGTCAGGAG GTGGGTCAGG AGGTGGATCC 600 O:\92\92747.DOC -116 200413407

GGAGGTGGCA CCCAGGACTG CTCCTTCCAA AAAATCCGTG AGCTGTCTGA CTACCTGCTT CTGCAGGACG AGGAGCTCTG CGGGGGCCTC GAGCGGCTCA AGACTGTCGC TGGGTCCAAG GAGATACACT TTGTCACCAA ATGTGCCTTT CAG CACAGCCCCA TCTCCTCCGA CTTCGCTGTC 660 CAAGATTACC CAGTCACCGT GGCCTCCAAC 720 TGGCGGCTGG TCCTGGCACA GCGCTGGATG 780 ATGCAAGGCT TGCTGGAGCG CGTGAACACG 840 CAGCCCCCCC CCAGCTGTCT TCGCTTCGTC 卯0 903 (2)序列編號NO·· 209資料： (i)序列特性： (A) 長度：921鹼基對 (B) 形式：核酸 (C) 股數：單

(D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 209 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CAAWCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTMGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC TTCTAATCTG CAAGATGAAG AGCTGTGCGG GGGCCTCTGG 480 CGGCTGGTCC TGGCACAGCG CTGGATGGAG CGGCTCAAGA CTGTCGCTGG GTCCAAGATG 540 CAAGGCTTGC TGGAGCGCGT GAACACGGAG ATACACTTTG TCACCAAATG TGCCTTTCAG 600 CCCCCCCCCA GCTGTCTTCG CTTCGTCCAG ACCAACATCT CCCGCCTCCT GCAGGAGACC 660 TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG ATCACTCGCC AGAACTTCTC CCGGTGCCTG 720 GAGCTGCAGT GTCAGCCCGA CTCCTCAACC CTGGGCGGTG GGTCAGGAGG TGGGTCAGGA 780 GGTGGATCCG GAGGTGGCTC AGGGGGAGGT AGTGGTACCC AGGACTGCTC CTTCCAACAC 840 AGCCCCATCT CCTCCGACTT CGCTGTCAAA ATCCGTGAGC TGTCTGACTA CCTGCTTCAA 900 GATTACCCAG TCACCGTGGC C 921

(2)序列編號NO: 210資料： (i)序列特性： (A)長度：921鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 210

GCTAACTGCT

TTGCTGGACC

CTATAATGAT

CGAACAACCT

CGATGAAATT

CAATTCTGAA

ATACATCACT

GACATGGATA TAAAGAGACC ACCTAACCCT 60 TCCTGATGGA ACGAAACCTT 120 O:\92\92747.DOC -117- 200413407 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC CAACCTGCAA GATGAAGAGC TGTGTGGGGG CCTCTGGCGG 480 CTGGTCCTGG CACAGCGCTG GATGGACCGG CTCAAGACTG TCGCTGGGTC CAAGATGCAA 540 GGCTTGCTGG AGCGCGTGAA CACGGAGATA CACTTTGTCA CCAAATGTGC CTTTCAGCCC 600 CCCCCCAGCT GTCTTCGCTT CGTCCAGACC AACATCTCCC GCCTCCTGCA GGAGACCTCC 660 GAGCAGCTGG TGGCGCTGAA GCCCTGGATC ACTCGCCAGA ACITCTCCCG GTGCCTGGAG 720 CTGCAGTGTC AGCCCGACTC CTCAACCCTG GGCGGTGGGT CAGGAGGTGG GTCAGGAGGT 780 GGATCCGGAG GTGGCTCAGG GGGAGGTAGT GGTACCCAGG ACTGCTCCTT CCAACACAGC 840 CCCATCTCCT CCGACTTCGC TGTCAAAATC CGTGAGCTGT CTGACTACCT GCTTCAAGAT 900 TACCCAGTCA CCGTGGCCTC C 921 (2)序列編號NO: 211資料： (i)序列特性： (A) 長度：921鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 211 GCTAACTGCT CTATAATGAT CGATGAMTT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CAATTCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC TCTGCAGGAT GAGGAACTGT GCGGCGGCCT CTGGCGGCTG 480 CTCCTGGCAC AGCGCTGGAT GGAGCGGCTC AAGACTGTCG CTGGGTCCAA GATGCAAGGC 540 TTGCTGGAGC GCGTGAACAC GGAGATACAC TTTGTCACCA AATGTGCTTT TCAGCCCCCC 600 CCCAGCTGTC TTCGCTTCGT CCAGACCAAC ATCTCCCGCC TCCTGCAGGA GACCTCCGAG 660 CAGCTGGTGG CGCTGAAGCC CTGGATCACT CGCCAGAACT TCTCCCGGTG CCTGGAGCTG 720 CAGTGTCAGC CCGACTCCTC AACCCTGGGC GGTGGGTCAG GAGGTGGGTC AGGAGGTGGA 780 TCCGGAGGTG GCTCAGGGGG AGGTAGTGGT ACCCAGGACT GCTCCTTCCA ACACAGCCCC 840 ATCTCCTCCG ACTTCGCTGT CAAAATCCGT GAGCTGTCTG ACTACCTGCT TCAAGATTAC 900 CCAGTCACCG TGGCCTCCAA C 921 (2)序列編號NO: 212資料： (i)序列特性： (A) 長度：921鹼基對 (B) 形式：核酸 O:\92\92747.DOC -118- 200413407 (c)股數：單 (D)拓撲結構：線形 (xi)序列描述：序列編號NO: 212 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CAATTCTGAA GACATGGATA TCCTGATGGA ACGAAACCIT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC TCAAGATGAA GAGCTGTGTG GTGGTCTCTG GCGGCTGGTC 480 CTGGCACAGC GCTGGATGGA GCGGCTCAAG ACTGTCGCTG GGTCCAAGAT GCAAGGCTTG 540 CTGGAGCGCG TGAACACGGA GATACACTTT GTCACCAAAT GTGCCTTTCA GCCCCCCCCC 600 AGCTGTCITC GCTTCGTCCA GACCAACATC TCCCGCCTCC TGCAGGAGAC CTCCGAGCAG 660 CTGGTGGCGC TGAAGCCCTG GATCACTCGC CAGAACTTCT CCCGGTGCCT GGAGCTGCAG 720 TGTCAGCCCG ACTCCTCAAC CCTGGGCGGT GGGTCAGGAG GTGGGTCAGG AGGTGGATCC 780 GGAGGTGGCT CAGGGGGAGG TAGTGGTACC CAGGACTGCT CCTTCCAACA CAGCCCCATC 840 TCCTCCGACT TCGCTGTCAA AATCCGTGAG CTGTCTGACT ACCTGCTTCA AGATTACCCA 900 GTCACCGTGG CCTCCAACCT G 921 (2)序列編號NO: 213資料 • (i)序列特性： (A)長度：921鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 213 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CAATTCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAACC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC TGAAGAACTG TCTGGTGGTC TGTGGCGGCT GGTCCTGGCA 480 CAGCGCTGGA TGGAGCGGCT CAAGACTGTC GCTGGGTCCA AGATGCAAGG CTTGCTGGAG 540 CGCGTGAACA CGGAGATACA CTTTGTCACC AAATGTGCCT TTCAGCCCCC CCCCAGCTGT 600 CTTCGCTTCG TCCAGACCAA CATCTCCCGC CTCCTGCAGG AGACCTCCGA GCAGCTGGTG 660 GCGCTGaXGC CCTGGATCAC TCGCCAGAAC TTCTCCCGGT GCCTGGAGCT GCAGTGTCAG 720 CCCGACTCCT CAACCCTGGG CGGTGGGTCA GGAGGTGGGT CAGGAGGTGG ATCCGGAGGT 780 GGCTCAGGGG GAGGTAGTGG TACCCAGGAC TGCTCCTTCC AACACAGCCC CATCTCCTCC 840 GACTTCGCTG TCAAAATCCG TGAGCTGTCT GACTACCTGC TTCAAGAm CCCAGTCACC 900 GTGGCCTCCA ACCTGCAGGA C 921 O:\92\92747.DOC -119- 200413407 (2)序列編號NO: 214資料： (i)序列特性： (A) 長度·· 921鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO·· 214 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CAATTCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTM TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 tatctgg™ CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC TGAGCTGTGT GGTGGCCTGT GGCGTCTGGT CCTGGCACAG 480 CGCTGGATGG AGCGGCTCAA GACTGTCGCT GGGTCCAAGA TGCAAGGCTT GCTGGAGCGC 540 GTGAACACGG AGATACACTT TGTCACCAAA TGTGCCTTTC AGCCCCCCCC CAGCTGTCIT 600 CGCTTCGTCC AGACCAACAT CTCCCGCCTC CTGCAGGAGA CCTCCGAGCA GCTGGTGGCG 660 CTGAAGCCCT GGATCACTCG CCAAAACTTC TCCCGGTGCC TGGAGCTGCA GTGTCAGCCC 720 GACTCCTCAA CCCTGGGCGG TGGGTCAGGA GGTGGGTCAG GAGGTGGATC CGGAGGTGGC 780 TCAGGGGGAG GTAGTGGTAC CCAGGACTGC TCCTTCCAAC ACAGCCCCAT CTCCTCCGAC 840 TTCGCTGTCA AAATCCGTGA GCTGTCTGAC TACCTGCTTC MGATTACCC AGTCACCGTG 900 GCCTCCAACC TGCAGGACGA G 921

(2)序列編號NO: 215資料：

(i)序列特性： (A) 長度：921鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO·. 215 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CAATTCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC TCTGTGCGGT GGTCTGTGGC GTCTGGTCCT GGCACAGCGC 480 O:\92\92747.DOC -120- 200413407 TGGATGGAGC GGCTCAAGAC TGTCGCTGGG TCCAAGATGC AAGGCTTGCT GGAGCGCGTG 540 AACACGGAGA TACACTTTGT CACCAAATGT GCCTTTCAGC CCCCCCCCAG CTGTCTTCGC 600 TTCGTCCAGA CCAACATCTC CCGCCTCCTG CAGGAGACCT CCGAGCAGCT GGTGGCGCTG 660 AAGCCCTGGA TCACTCGCCA GAACTTCTCC CGGTGCCTGG AGCTGCAGTG TCAGCCCGAC 720 TCCTCAACCC TGGGCGGTGG GTCAGGAGGT GGGTCAGGAG GTGGATCCGG AGGTGGCTCA 780 GGGGGAGGTA GTGGTACCCA GGACTGCTCC TTCCAACACA GCCCCATCTC CTCCGACTTC 840 GCTGTCAAAA TCCGTGAGCT GTCTGACTAC CTGCTTCAAG AmCCCAGT CACCGTGGCC 900 TCCAACCTGC AGGACGAGGA G 921 (2)序列編號NO·. 216資料： (i)序列特性： (A) 長度：921鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 216 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CAATTCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 mGkGGCkk TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGm CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC TTCTAATCTG CAAGATGAAG AGCTGTGCGG GGGCCTCTGG 480 CGGCTGGTCC TGGCACAGCG CTGGATGGAG CGGCTCAAGA CTGTCGCTGG GTCCAAGATG 540 CAAGGCTTGC TGGAGCGCGT GAACACC3GAG ATACACTTTG TCACCAAATG TGCCmCAG 600 CCCCCCCCCA GCTGTCITCG CTTCGTCCAG ACCAACATCT CCCGCCTCCT GCAGGAGACC 660 TCCGAGCAGC TGGTGGCGCT GaXGCCCTGG ATCACTCGCC AGAACTTCTC CCGGTGCCTG 720 GAGCTGCAGT GTCAGCCCGA CTCCTCAACC CTCCGCGGTG GGTCAGGAGG TGGGTCAGGA 780 GGTGGATCCG GAGGTGGCTC AGGGGGAGGT AGTGGTACCC AGGACTGCTC CTTCCAACAC 840 AGCCCCATCT CCTCCGACTC CGCTGTCAAA ATCCGTGAGC TGTCTGACTA CCTGCTTCAA 900 GATTACCCAG TCACCGTGGC C 921 (2)序列編號NO: 217資料： (i)序列特性： (A) 長度：921鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 217 O:\92\92747.DOC -121- 200413407 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CAATTCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC TCAnGATGAA GAACTGTGCG GTGGTCTCTG GCGGCTGGTC 480 CTGGCACAGC GCTGGATGGA GCGGCTCAAG ACTGTCGCTG GGTCCAAGAT GCAAGGCTTG 540 CTGGAGCGCG TGAACACGGA GATACACTTT GTCACCAAAT GTGCCTTTCA GCCCCCCCCC 600 AGCTGTCTTC GCTTCGTCCA GACCAACATC TCCCGCCTCC TGCGGGAGAC CTCCGAGCAG 660 CCGGTGGCGC TGAAGCCCTG GATCACTCGC CAGAACITCT CCCGGTGCCT GGAGCTGCAG 720 TGTCAGCCCG ACTCCTCAAC CCTGGGCGGT GGGTCAGGAG GTGGGTCAGG AGGTGGATCC 780 GGAGGTGGCT CAGGGGGAGG TAGTGGTACC CAGGACTGCT CCTTCCAACA CAGCCCCATC 840 TCCTCCGACT TCGCTGTCAA AATCCGTGAG CTGTCTGACT ACCTGCTTCA AGATTACCCA 900 GTCACCGTGG CCTCCAACCT G 921

(2)序列編號NO: 218資料： (i)序列特性： (A) 長度：921鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 218

GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTAACCCT 60 TTGCTGGACC CGAACAACCT CAATTCTGAA GACATGGATA TCCTGATGGA ACGAAACCTT 120 CGAACTCCAA ACCTGCTCGC ATTCGTAAGG GCTGTCAAGC ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC TCTGTGCGGT GGTCTGTGGC GTCTGGTCCT GGCACAGCGC 480 TGGATGGAGC GGCTCAAGAC TGTCGCTGGG TCCAAGATGC AAGGCTTGCT GGAGCGCGTG 540 AACACGGAGA TACACTTTGT CACCAAATGT GCCITTCAGC CCCCCCCCAG CTGTCTTCGC 600 TTCGTCCAGA CCAACATCTC CCGCCTCCTG CAGGAGACCT CCGAGCAGCT GGTGGCGCTG 660 AAGCCCTGGA TCACTCGCCA GAACITCTCC CGGTGCCTGG AGCTGCAGTG TCGGCCCGAC 720 TCCTCAACCC TGGGCGGTGG GTCAGGAGGT GGGTCAGGAG GTGGATCCGG AGGTGGCTCA 780 GGGGGAGGTA GTGGTACCCA GGACTGCTCC TOCAACACA GCCCCATCTC CTCCGACITC 840 GCTGTCAAGA TCCGTGAGCT GTCTGACTAC CTGCTTCAAG AmCCCAGT CACCGTGGCC 900 TCCAACCTGC AGGACGAGGA G 921 (2)序列編號NO: 219資料： (i)序列特性： (A)長度：906鹼基對 O:\92\92747.DOC -122-

200413407 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 219 GCTGATGAAG AACTGTGTGG TGGTCTGTGG CGGCTGGTCC TGGCACAGCG CTGGATGGAG 60 CGGCTCAAGA CTGTCGCTGG GTCCAAGATG CAAGGCTTGC TGGAGCGCGT GAACACGGAG 120 ATACACTTTG TCACCAAATG TGCCTTTCAG CCCCCCCCCA GCTGTCTTCG CTTCGTCCAG 180 ACCAACATCT CCCGCCTCCT GCAGGAGACC TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG 240 ATCACTCGCC AGAACTTCTC CCGGTGCCTG GAGCTGCAGT GTCAGCCCGA CTCCTCAACC 300 CTGGGCGGTG GGTCAGGAGG TGGGTCAGGA GGTGGATCCG GAGGTGCjCTC AGGGGGAGGT 360 AGTGGTACCC AGGACTGCTC CTTCCAACAC AGCCCCATCT CCTCCGACTT CGCTGTCAAA 420 ATCCGTGAGC TGTCTGACTA CCTGCTTCAA GATTACCCAG TCACCGTGTA CGTAGAGGGC 480 GGTGGAGGCT CCCCGGGTGA ACCGTCTGGT CCAATCTCTA CTATCAACCC GTCTCCTCCG 540 TCTAAAGAAT CTCATAAATC TCCAAACATG GCTAACTGCT CTATAATGAT CGATGAAATT 600 ATACATCACT TAAAGAGACC ACCTAACCCT nGCTGGACC CGAACAACCT CA/OTCTGAA 660 GACATGGATA TCCTGATGGA ACGAAACCTT CGAACTCCAA ACCTGCTCGC ATTCGTAAGG 720 GCTGTCAAGC ACTTAGAAAA TGCATCAGGT ATTGAGGCAA TTCTTCGTAA TCTCCAACCA 780 TGTCTGCCCT CTGCCACGGC CGCACCCTCT CGACATCCAA TCATCATCAS GGCAGGTGAC 840 TGGCAAGAAT TCCGGGAAAA ACTGACGTTC tatctgg™ CCCTTGAGCA AGCGCAGGAA 900 CAACAG 906 (2)序列編號NO: 220資料：

⑴序列特性： (A)長度：888鹼基對 (B) 形式：核酸

(C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 220 GCGGATGAGG AGCTGTGCGG TGGCCTCTGG CGGCTGGTCC TGGCACAGCG CTGGATGGAG 60 CGGCTCAAGA CTGTCGCTGG GTCCAAGATG CAAGGCTTGC TGGAGCGCGT GAACACGGAG 120 ATACACTTTG TCACCAAATG TGCCTTTCAG CCCCCCCCCA GCTGTCTTCG CTTCGTCCAG 180 ACCAACATCT CCCGCCTCCT GCAGGAGACC TCCGAGCAGC TGGTGGCGCT GAGGCCCTGG 240 ATCACTCGCC AGAACTTCTC CCGGTGCCTG GAGCTGCAGT GTCAGCCCGA CTCCTCAACC 300 CTGGGCGGTG GGTCAGGAGG TGGATCCGGA GGTACCCAGG ACTGCTCCTT CCAACACAGC 360 CCCATCTCCT CCGACTTCGC TGTCAAAATC CGTGAGCTGT CTGACTACCT GCTTCAAGAT 420 TACCCAGTCA CCGTGGCCTC CAACCTGCAG TACGTAGAGG GCGGTGGAGG CTCCCCGGGT 480 GAACCGTCTG GTCCAATCTC TACTATCAAC CCGTCTCCTC CGTCTAAAGA ATCTCATAAA 540 TCTCCAAACA TGGCTAACTG CTCTATAATG ATCGATGAAA TTATACATCA CTTAAAGAGA 600 CCACCTAACC CTTTGCTGGA CCCGAACAAC CTCAATTCTG AAGACATGGA TATCCTGATC 660 GAACGAAACC TTCGAACTCC AAACCTGCTC GCATTCGTAA GGGCTGTCAA GCACTTAGAA 720 AATGCATCAG GTATTGAGGC AATTCTTCGT AATCTCCAAC CATGTCTGCC CTCTGCCACG 780 GCCGCACCCT CTCGACATCC AATCATCATC AAGGCAGGTG ACTGGCAAGA ATTCCGGGAA 840 O:\92\92747.DOC -123- 200413407 888

AAACTGACGT TCTATCTGGT TACCCTTGAG CAAGCGCAGG AACAACAG (2)序列編號NO: 221資料 • (i)序列特性： (A)長度：903鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 ⑻)序列描述：序列編號NO: 221 GCCGACGAGG AGCTGTGCGG TGGCCTCTGG CGGCTGGTCC TGGCACAGCG CTGGATGGAG 60 CGGCTCAAGA CTGTCGCTGG GTCCAAGATG CAAGGCTTGC TGGAGCGCGT GAACACGGAG 120 ATACACHTG TCACCAAATG TGCCTTTCAG CCCCCCCCCA GCTGTCTTCG CTTCGTCCAG 180 ACCAACATCT CCCGCCTCCT GCAGGAGACC TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG 240 ATCACTCGCC AGAACTTCTC CCGGTGCCTG GAGCTGCAGT GTCAGCCCGA CTCCTCAACC 300 CTGGGCGGTG GGTCAGGAGG TGGGTCAGGA GGTGGATCCG GAGGTGGAAC CCAGGACTGC 360 TCCTTCCAAC ACAGCCCCAT CTCCTCCGAC TTCGCTGTCA AAATCCGTGA GCTGTCTGAC 420 TACCTGCTTC MGATTACCC AGTCACCGTG GCCTCCAACC TGCAGTACGT AGAGGGCGGT 480 GGAGGCTCCC CGGGTGAACC GTCTGGTCCA ATCTCTACTA TCAACCCGTC TCCTCCGTCT 540 AAAGAATCTC ATAAATCTCC AAACATGGCT AACTGCTCTA TAATGATCGA TGAAATTATA 600 CATCACTTAA AGAGACCACC TAACCCTTTG CTGGACCCGA ACAACCTCAA TTCTGAAGAC 660 ATGGATATCC TGATGGAACG AAACCTTCGA ACTCCAAACC TGCTCGCATT CGTAAGGGCT 720 GTCAAGCACT TAGAAAATGC ATCAGGTATT GAGGCAATTC TTCGTMTCT CCAACCATGT 780 CTGCCCTCTG CCACGGCCGC ACCCTCTCGA CATCCAATCA TCATCAAGGC AGGTGACTGG 840 CAAGAATTCC GGGAAAAACT GACGTTCTAT CTGGTTACCC TTGAGCaXGC GCAGGAACAA 900 CAG 903 (2)序列編號NO: 222資料 • (i)序列特性： (A)長度：921鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 222 GCAGACGAGG AGCTGTGCGG TGGCCTCTGG CGGCTGGTCC TGGCACAGCG CTGGATGGAG 60 CGGCTCAAGA CTGTCGCTGG GTCCAAGATG CAAGGCTTGC TGGAGCGCGT GAACACGGAG 120 ATACACTTTG TCACCAAATG TGCCmCAG CCCCCCCCCA GCTGTCTTCG CTTCGTCCAG 180 ACCAACATCT CCCGCCTCCT GCAGGAGACC TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG 240 ATCACTCGCC AGAACTTCTC CCGGTGCCTG GAGCTGCAGT GTCAGCCCGA CTCCTCAACC 300 CTGGGCGGTG GGTCAGGAGG TGGGTCAGGA GGTGGATCCG GAGGTGC5CTC AGGGGGAGGT 360 AGTGGTACCC AGGACTGCTC CTTCCAACAC AGCCCCATCT CCTCCGACTT CGCTGTCAAA 420

O:\92\92747.DOC -124- 200413407 ATCCGTGAGC TGTCTGACTA CCTGCTTCAA GATTACCCAG TCACCGTGGC CTCCAACCTG 480 CAGTACGTAG AGGGCGGTGG AGGCTCCCCG GGTGAACCGT CTGGTCCAAT CTCTACTATC 540 AACCCGTCTC CTCCGTCTAA AGAATCTCAT AAATCTCCAA ACATGGCTAA CTGCTCTATA 600 ATGATCGATG AAATTATACA TCACTTAAAG AGACCACCTA ACCCTTTGCT GGACCCGAAC 660 MCCKMTT CTGAAGACAT GGATATCCTG ATGGAACGAA ACCTTCGAAC TCCAAACCTG 720 CTCGCATTCG TAAGGGCTGT CAAGCACTTA GAAAATGCAT CAGGTATTGA GGCAATTCTT 780 CGTAATCTCC AACCATGTCT GCCCTCTGCC ACGGCCGCAC CCTCTCGACA TCCAATCATC 840 ATCAAGGCAG GTGACTGGCA AGAATTCCGG GAAAAACTGA CGHCTATCT GGTTACCCTT 900 GAGCAAGCGC AGGAACAACA G 921 (2)序列編號NO: 223資料 ·· (i)序列特性： (A)長度：903鹼基對 (B)形式：核酸 (c)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 223 GCGGACGAGG AGCTGTGCGG TCGCCTCTGG CGGCTGGTCC TGGCACAGCG CTGGATGGAG 60 CGGCTCAAGA CTGTCGCTGG GTCCAAGATG CAAGGCCTGC TGGAGCGCGT GAACACGGAG 120 ATACACTTTG TCACCAAATG TGCCTTTCAG CCCCCCCCCA GCTGTCTTCG CCTCGTCCAG 180 ACCAACATCT CCCGCCTCCT GCAGGAGACC TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG 240 ATCACTCGCC AGAACTTCTC CCGGTGCCTG GAGCTGCAGT GTCAGCCCGA CTCCTCAACC 300 CTGGGCGGTG GGTCAGGAGG TGGGTCAGGA GGTGGATCCG GAGGTGGAAC CCAGGACTGC 360 TCCTTCCAAC ACAGCCCCAT CTCCTCCGAC TTCGCTGTCA AAATCCGTGA GCTGTCTGAC 420 TACCTGCTTC AAGATTACCC AGTCACCGTG GCCTCCAACC TGCAGTACGT AGAGGGCGGT 480 GGAGGCTCCC CGGGTGAACC GTCTGGTCCA ATCTCTACTA TCAACCCGTC TCCTCCGTCT 540 AAAGAATCTC ATAAATCTCC AAACATGGCT AACTGCTCTA TAATGATCGA TGAAATTATA 600 CATCACTTAA AGAGACCACC TAACCCTTTG CTGGACCCGA ACAACCTCAA TTCTGAAGAC 660 ATGGATATCC TGATGGAACG AAACCTTCGA ACTCCAAACC TGCTCGCATT CGTAAGGGCT 720 GTCAAGCACT TAGAAAATGC ATCAGGTATT GAGGCAATTC TTCGTAATCT CCAACCATGT 780 CTGCCCTCTG CCACGGCCGC ACCCTCTCGA CATCCAATCA TCATCAAGGC AGGTGACTGG 840 CAAGAATTCC GGGAAAAACT GACGTTCTAT CTGGTTACCC HGAGCaXGC GCAGGAACAA 900 CAG 903 (2)序列編號NO: 224資料：

⑴序列特性： (A)長度：921鹼基對 (B) 形式：核 (C) 股數：單 (D) 拓撲結構 (xi)序列描述：酸 :線形序列編號NO: 224 O:\92\92747.DOC 125- 200413407 GCGGATGAGG AGCTGTGTGG TGGCCTCTGG CGGCTGGTCC TGGCACAGCG CTGGATGGGG 60 GGGCTCAAGA CTGTCGCTGG GTCCAAGATG CAAGGCTTGC TGGAGCGCGT GAACACGGAG 120 ATACACTTTG TCACCAAATG TGCCTTTCAG CCCCCCCCCA GCTGTCTTCG CTTCGTCCAG 180 ACCAACATCT CCCGCCTCCT GCAGGAGACC TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG 240 ATCACTCGCC AGAACTTCTC CCGGTGCCTG GAGCTGCAGT GTCAGCCCGA CTCCTCAACC 300 CTGGGCGGTG GGTCAGGAGG TGGGTCAGGA GGTGGATCCG GAGGTGGCTC AGGGGGAGGT 360 AGTGGTACCC AGGACTGCTC CTTCCAACAC AGCCCCATCT CCTCCGACTT CGCTGTCAAA 420 ATCCGTGAGC TGTCTGACTA CCTGCTTCAA GATTACCCAG TCACCGTGGC CTCCAACCTG 480 CAGTACGTAG AGGGCGGTGG AGGCTCCCCG GGTGAACCGT CTGGTCCAAT CTCTACTATC 540 AACCCGTCTC CTCCGTCTAA AGAATCTCAT AAATCTCCAA ACATGGCTAA CTGCTCTATA 600 ATGATCGATG AAATTATACA TCACTTAAAG AGACCACCTA ACCCTTTGCT GGACCCGAAC 660 AACCTCAATT CTGAAGACAT GGATATCCTG ATGGAACGAA ACCTTCGAAC TCCAAACCTG 720 CTCGCATTCG TAAGGGCTGT CAAGCACTTA GAAAATGCAT CAGGTATTGA GGCAATTCTT 780 CGTAATCTCC AACCATGTCT GCCCTCTGCC ACGGCCGCAC CCTCTCGACA TCCAATCATC 840 ATCAAGGCAG GTGACTGGCA AGAATOCGG GAAAAACTGA CGTTCTATCT GGTTACCCTT 900 GAGCAAGCGC AGGAACAACA G 921 (2)序列編號NO: 225資料：

⑴序列特性： (A)長度：904鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 225 GGCCGATTAC CCAGTCACCG TGGCCTCCAA CCTGCAGGAC GAGGAGCTCT GCGGGGGCCT 60 CTGGCGGCTG GTCCTGGCAC AGCGCTGGAT GGAGCGGCTC AAGACTGTCG CTGGGTCCAA 120 GATGCAAGGC TTGCTGGAGC GCGTGAACAC GGAGATACAC TTTGTCACCA AATGTGCCIT 180 TCAGCCCCCC CCCAGCTGTC TTCGCTTCGT CCAGACCAAC ATCTCCCGCC TCCTGCAGGA 240 GACCTCCGAG CAGCTGGTGG CGCTGAAGCC CTGGATCACT CGCCAGAACT TCTCCCGGTG 300 CCTGGAGCTG CAGTGTCAGC CCGACTCCTC AACCCTGGGC GGTGGGTCAG GAGGTGGGTC 360 AGGAGGTGGA TCCGGAGGTG GCACCCAGGA CTGCTCCrrC CAACACAGCC CCATCTCCTC 420 CGACTTCGCT GTCAAAATCC GTGAGCTGTC TGACTACCTG CTTCAATACG TAGAGGGCGG 480 TGGAGGCTCC CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC 540 TAAAGAATCT CATAAATCTC CAAACATGGC TAACTGCTCT ATAATGATCG ATGAAATTAT 600 ACATCACTTA AAGAGACCAC CTAACCCTTT GCTGGACCCG AACAACCTCA ATTCTGAAGA 660 CATGGATATC CTGATGGAAC GAAACCTTCG AACTCCAAAC CTGCTCGCAT TCGTAAGGGC 720 TGTCAAGCAC TTAGAAAATG CATCAGGTAT TGAGGCAATT CTTCGTAATC TCCAACCATG 780 TCTGCCCTCT GCCACGGCCG CACCCTCTCG ACATCCAATC ATCATCAAGG CAGGTGACTG 840 GCAAGAATTC CGGGAAAAAC TGACGTTCTA TCTGGTTACC CTTGAGCAAG CGCAGGAACA 900 ACAG 904

(2)序列編號NO·· 226資料： (i)序列特性： O:\92\92747.DOC -126- 200413407 (A) 長度：903鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 226 GCCGCCTCCA ACCTGCAGGA CGAGGAGCTC TGCGGGGGCC TCTGGCGGCT GGTCCTGGCA CAGCGCTGGA TGGAGCGGCT CAAGACTGTC GCTGGGTCCA AGATGCAAGG CITGCTGGAG CGCGTGAACA CGGAGATACA CnTGTCACC AAATGTGCCT TTCAGCCCCC CCCCAGCTGT CTTCGCTTCG TCCAGACCAA CATCTCCCGC CTCCTGCAGG AGACCTCCGA GCAGCTGGTG GCGCTGAAGC CCTGGATCAC TCGCCAGAAC TTCTCCCGGT GCCTGGAGCT GCAGTGTCAG CCCGACTCCT CAACCCTGGG CGGTGGGTCA GGAGGTGGGT CAGGAGGTGG ATCCGGAGGT GGCACCCAGG ACTGCTCCTT CCAACACAGC CCCATCTCCT CCGACTTCGC TGTCAAAATC CGTGAGCTGT CTGACTACCT GCTTCAAGAT TACCCAGTCA CCGTGTACGT AGAGGGCGGT GGAGGCTCCC CGGGTGAACC GTCTGGTCCA ATCTCTACTA TCAACCCGTC TCCTCCGTCT AAAGAATCTC ATAAATCTCC AAACATGGCT AACTGCTCTA TAATGATCGA TGAAATTATA CATCACTTAA AGAGACCACC TAACCCTTTG CTGGACCCGA ACAACCTCAA TTCTGAAGAC ATGGATATCC TGATGGAACG AAACCTTCGA ACTCCAAACC TGCTCGCATT CGTAAGGGCT GTCAAGCACT TAGAAAATGC ATCAGGTAH GAGGCAATTC TTCGTAATCT CCAACCATGT CTGCCCTCTG CCACGGCCGC ACCCTCTCGA CATCCAATCA TCATCAAGGC AGGTGACTGG CAAGAATTCC CAG GGGAAAAACT GACGTTCTAT CTGGTTACCC HGAGCAAGC GCAGGAACAA (2)序列編號NO: 227資料 60 000000000000003 284062840628400 ⑴序列特性： (A)長度：903鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 227

GCCGTCGCTG GGTCCAAGAT GCAAGGCTTG CTGGAGCGCG TGAACACGGA GATACACTTT GTCACCAAAT GTGCCTTTCA GCCCCCCCCC AGCTGTCITC GCTTCGTCCA GACCAACATC TCCCGCCTCC TGCAGGAGAC CTCCGAGCAG CTGGTGGCGC TGAAGCCCTG GATCACTCGC CAGAACITCr CCCGGTGCCT GGAGCTGCAG TGTCAGCCCG ACTCCTCAAC CCTGGGCGGT GGGTCAGGAG GTGGGTCAGG AGGTGGATCC GGAGGTGGCA CCCAGGACTG CTCCTTCCAA CACAGCCCCA TCTCCTCCGA CTTCGCTGTC AAAATCCGTG AGCTGTCTGA CTACCTGCTT CAGGATTACC CAGTCACCGT GGCCTCCAAC CTGCAGGACG AGGAGCTCTG CGGGGGCCTC TGGCGGCTGG TCCTGGCACA GCGCTGGATG GAGCGGCTCA AGACTTACGT AGAGGGCGGT GGAGGCTCCC CGGGTGAACC GTCTGGTCCA ATCTCTACTA TCAACCCGTC TCCTCCGTCT AAAGAATCTC ATAAATCTCC AAACATGGCT AACTGCTCTA TAATGATCGA TGAAATTATA CATCACTTAA AGAGACCACC TAACCCTTTG CTGGACCCGA ACAACCTCAA TTCTGAAGAC ATGGATATCC TGATGGAACG AAACCTTCGA ACTCCAAACC TGCTCGCATT CGTAAGGGCT GTCAAGCACT TAGAAAATGC ATCAGGTATT GAGGCAATTC TTCGTAATCT CCAACCATGT

r L r L r V Γν /V λικ /IV rlv /IV /—X 0284062840628 6 1 -—-2334456677 O:\92\92747.DOC -127 200413407

CTGCCCTCTG CCACGGCCGC ACCCTCTCGA CATCCAATCA TCATCAAGGC AGGTGACTGG CAAGAATTCC GGGAAAAACT GACGTTCTAT CTGGTTACCC TTGAGCAAGC GCAGGAACAA CAG (2)序列編號NO: 228資料 • (i)序列特性： (A)長度：903鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 228 GCCTCCAAGA TGCAAGGCTT GCTGGAGCGC GTGAACACGG AGATACACTT TGTCACCAAA TGTGCCTTTC AGCCCCCCCC CAGCTGTCTT CGCTTCGTCC AGACCAACAT CTCCCGCCTC CTGCAGGAGA CCTCCGAGCA GCTGGTGGCG CTGAAGCCCT GGATCACTCG CCAGAACTTC TCCCGGTGCC TGGAGCTGCA GTGTCAGCCC GACTCCTCAA CCCTGGGCGG TGGGTCAGGA GGTGGGTCAG GAGGTGGATC CGGAGGTGGC ACCCAGGACT GCTCCTTCCA ACACAGCCCC ATCTCCTCCG ACTTCGCTGT CAAAATCCGT GAGCTGTCTG ACTACCTGCT TCAAGATTAC CCAGTCACCG TGGCCTCCAA CCTGCAGGAC GAGGAGCTCT GCGGGGGCCT CTGGCGGCTG GTCCTGGCAC AGCGCTGGAT GGAGCGGCTC AAGACTGTCG CTGGCTACGT AGAGGGCGGT GGAGGCTCCC CGGGTGAACC GTCTGGTCCA ATCTCTACTA TCAACCCGTC TCCTCCGTCT AAAGAATCTC ATAAATCTCC AAACATGGCT AACTGCTCTA TAATGATCGA TGAAATTATA CATCACTTAA AGAGACCACC TAACCCTTTG CTGGACCCGA ACAACCTCAA TTCTGAAGAC ATGGATATCC TGATGGAACG AAACCTTCGA ACTCCAAACC TGCTCGCATT CGTAAGGGCT GTCAAGCACT TAGAAAATGC ATCAGGTAH GAGGCAATTC TTCGTAATCT CCAACCATGT CTGCCCTCTG CCACGGCCGC ACCCTCTCGA CATCCAATCA TCATCAAGGC AGGTGACTGG CAAGAATTCC GGGAAAAACT GACOTTCTAT CTGGTTACCC TTGAGCAAGC GCAGGAACAA CAG (2)序列編號NO: 229資料： (i)序列特性： (A)長度：903鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 229 GCCCCCCCCA GCTGTCTTCG CTTCGTCCAG ACCAACATCT CCCGCCTCCT GCAGGAGACC TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG ATCACTCGCC AGAACITCTC CCGGTGCCTG GAGCTGCAGT GTCAGCCCGA CTCCTCAACC CTGGGCGGTG GGTCAGGAGG TGGGTCAGGA GGTGGATCCG GAGGTGGCAC CCAGGACTGC TCCITCCAAC ACAGCCCCAT CTCCTCCGAC TTCGCTGTCA AAATCCGTGA GCTGTCTGAC TACCTGCTTC AAGATTACCC AGTCACCGTG 0 0 3 4 0 0 60 208040006020804000602080400003 0 2 8 4 0 6 112 3 O:\92\92747.DOC -128- 200413407 GCCTCCAACC TGCAGGACGA GGAGCTCTGC GGGGGCCTCT GGCGGCTGGT CCTGGCACAG 360 CGCTGGATGG AGCGGCTCAA GACTGTCGCT GGGTCCAAGA TGCAAGGCTT GCTGGAGCGC 420 GTGAACACGG AGATACACTT TGTCACCAAA TGTGCCTTTC AGCCGTACGT AGAGGGCGGT 480 GGAGGCTCCC CGGGTGAACC GTCTGGTCCA ATCTCTACTA TCAACCCGTC TCCTCCGTCT 540 AAAGAATCTC ATAAATCTCC AAACATGGCT AACTGCTCTA TAATGATCGA TGAAATTATA 600 CATCACTTAA AGAGACCACC TAACCCTTTG CTGGACCCGA ACAACCTCAA TTCTGAAGAC 660 ATGGATATCC TGATGGAACG AAACCTTCGA ACTCCAAACC TGCICGCm CGTAAGGGCT 720 GTCAAGCACT TAGAAAATGC ATCAGGTAn GAGGCAATTC TTCGTAATCT CCAACCATGT 780 CTGCCCTCTG CCACGGCCGC ACCCTCTCGA CATCCAATCA TCATCAAGGC AGGTGACTGG 840 CAAGAATTCC GGGAAAAACT GACGTTCTAT CTGGTTACCC TTGAGCAAGC GCAGGAACAA 900 CAG 903 (2)序列編號NO: 230資料： (i)序列特性： (A)長度：903鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 230 GCCACCAACA TCTCCCGCCT CCTGCAGGAG ACCTCCGAGC AGCTGGTGGC GCTGAAGCCC 60 TGGATCACTC GCCAGAACTT CTCCCGGTGC CTGGAGCTGC AGTGTCAGCC CGACTCCTCA 120 ACCCTGGGCG GTGGGTCAGG AGGTGGGTCA GGAGGTGGAT CCGGAGGTGG CACCCAGGAC 180 TGCTCCITCC AACACAGCCC CATCTCCTCC GACTTYGCTG TCAAAATCCG TGAGCTGTCT 240 GACTACCTGC ttcaaga™ CCCAGTCACC GTGGCCTCCA ACCTGCAGGA CGAGGAGCTC 300 TGCGGGGGCC TCTGGCGGCT GGTCCTGGCA CAGCGCTGGA TGGAGCGGCT CAAGACTGTC 360 GCTGGGTCCA AGATGCAAGG CTTGCTGGAG CGCGTGAACA CGGAGATACA CTTTGTCACC 420 AAATGTGCCT TTCAGCCCCC CCCCAGCTGT CTTCGCTTCG TCCAGTACGT AGAGGGCGGT 480 GGAGGCTCCC CGGGTGAACC GTCTGGTCCA ATCTCTACTA TCAACCCGTC TCCTCCGTCT 540 AAAGAATCTC ATAAATCTCC AAACATGGCT AACTGCTCTA TAATGATCGA TGAAATTATA 600 CATCACTTAA AGAGACCACC TAACCCITTG CTGGACCCGA ACAACCTCAA TTCTGAAGAC 660 ATGGATATCC TGATGGAACG AAACCTTCGA ACTCCAAACC TGCTCGCATT CGTAAGGGCT 720 GTCAAGCACT TAGAAAATGC ATCAGGTATT GAGGCAATTC TTCGTAATCT CCAACCATGT 780 CTGCCCTCTG CCACGGCCGC ACCCTCTCGA CATCCAATCA TCATCAAGGC AGGTGACTGG 840 CAAGAATTCC GGGAAAAACT GACGTTCTAT CTGGmCCC mkGCAkGC GCAGGAACAA 900 CAG 903 (2)序列編號NO: 231資料 • (i)序列特性：

(A)長度：903驗基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 O:\92\92747.DOC -129 200413407 (xi)序列描述：序列編號NO: 231 GCCCGCITCG TCCAGACCAA CATCTCCCGC CTCCTGCAGG AGACCTCCGA GCAGCTGGTG 60 GCGCTGAAGC CCTGGATCAC TCGCCAGAAC TTCTCCCGGT GCCTGGAGCT GCAGTGTCAG 120 CCCGACTCCT CAACCCTGGG CGGTGGGTCA GGAGGTGGGT CAGGAGGTGG ATCCGGAGGT 180 GGCACCCAGG ACTGCTCCTT CCAACACAGC CCCATCTCCT CCGACTTCGC TGTCAAAATC 240 CGTGAGCTGT CTGACTACCT GCTTCAAGAT TACCCAGTCA CCGTGGCCTC CAACCTGCAG 300 GACGAGGAGC TCTGCGGGGG CCTCTGGCGG CTGGTCCTGG CACAGCGCTG GATGGAGCGG 360 CTCAAGACTG TCGCTGGGTC CAAGATGCAA GGCTTGCTGG AACGCGTGAA CACGGAGATA 420 CACTTTGTCA CCAAATGTGC CTTTCAGCCC CCCCCCAGCT GTTTTTACGT AGAGGGCGGT 480 GGAGGCTCCC CGGGTGAACC GTCTGGTCCA ATCTCTACTA TCAACCCGTC TCCTCCGTCT 540 AAAGAATCTC ATAAATCTCC AAACATGGCT AACTGCTCTA TAATGATCGA TGAMTTATA 600 CATCACTTAA AGAGACCACC TAACCCTTTG CTGGACCCGA ACAACCTCAA TTCTGAAGAC 660 ATGGATATCC TGATGGAACG AAACCTTCGA ACTCCAAACC TGCTCGCm CGTAAGGGCT 720 GTCAAGCACT TAGAAAATGC ATCAGGTATT GAGGCAATTC TTCGTAATCT CCAACCATGT 780 CTGCCCTCTG CCACGGCCGC ACCCTCTCGA CATCCAATCA TCATCAAGGC AGGTGACTGG 840 CAAGAATTCC GGGAAAAACT GACGTTCTAT CTGGTTACCC TTGAGCAAGC GCAGGAACAA 900 CAG 903 (2)序列編號NO: 232資料 • (〇序列特性： (A)長度：921鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 232 GCTTCAAATC TGCAGGATGA AGAGCTGTGC GGGGGCCTCT GGCGGCTCGT CCTGGCACAG 60 CGCTGGATGG AGCGGCTCAA GACTGTCGCT GCjGTCCAAGA TGCAAGGCTT GCTGGAGCGC 120 GTGAACACGG AGATACACTT TGTCACCAAA TGTGCCTTTC AGCCCCCCCC CAGCTGTCTT 180 CGCTTCGTCC AGACCAACAT CTCCCGCCTC CTGCAGGAGA CCTCCGAGCA GCTGGTGGCG 240 CTGAAGCCCT GGATCACTCG CCAGAACTTC TCCCGGTGCC TGGAGCTGCA GTGTCAGCCC 300 GACTCCTCAA CCCTGGGCGG TGGGTCAGGA GGTGGGTCAG GAGGTGGATC CGGAGGTGGC 360 TCAGGGGGAG GTAGTGGTAC CCAGGACTGC TCCTTCCAAC ACAGCCCCAT CTCCTCCGAC 420 TTCGCTGTCA AAATCCGTGA GCTGTCTGAC TACCTGCTTC AAGATTACCC AGTCACCGTG 480 GCCTACGTAG AGGGCGGTGG AGGCTCCCCG GGTGAACCGT CTGGTCCAAT CTCTACTATC 540 AACCCGTCTC CTCCGTCTAA AGAATCTCAT AAATCTCCAA ACATGGCTAA CTGCTCTATA 600 ATGATCGATG AMTTATACA TCACTTAAAG AGACCACCTA ACCCTTTGCT GGACCCGAAC 660 AACCTCAATT CTGAAGACAT GGATATCCTG ATGGAACGAA ACCTTCGAAC TCCAAACCTG 720 CTCGCATTCG TAAGGGCTGT CAAGCACTTA GAAAATGCAT CAGGTAnGA GGCAATTCTT 780 CGTAATCTCC AACCATGTCT GCCCTCTGCC ACGGCCGCAC CCTCTCGACA TCCAATCATC 840 ATCAAGGCAG GTGACTGGCA AGMTTCCGG GAAAAACTGA CGTTCTATCT GGmCCCTT 900 GAGCAAGCGC AGGAACAACA G 921 (2)序列編號NO: 233資料： 200413407 ⑴序列特性： (A) 長度：921鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 233 GCTAATCTGC AAGATGAGGA GCTGTGCGGG GGCCTCTGGC GGCTGGTCCT GGCACAGCGC 60 TGGATGGAGC GGCTCAAGAC TGTCGCTGGG TCCAAGATGC AAGGCTTGCT GGAGCGCGTG 120 AACACGGAGA TACACTTTGT CACCAAATGT GCCTTTCAGC CCCCCCCCAG CTGTCTTCGC 180 TTCGTCCAGA CCAACATCTC CCGCCTCCTG CAGGAGACCT CCGAGCAGCT GGTGGCGCTG 240 AAGCCCTGGA TCACTCGCCA GAACTTCTCC CGGTGCCTGG AGCTGCAGTG TCAGCCCGAC 300 TCCTCAACCC TGGGCGGTGG GTCAGGAGGT GGGTCAGGAG GTGGATCCGG AGGTGGCTCA 360 GGGGGAGGTA GTGGTACCCA GGACTGCTCC TTCCAACACA GCCCCATCTC CTCCGACTTC 420 GCTGTCAAAA TCCGTGAGCT GTCTGACTAC CTGCTTCAAG ATTACCCAGT CACCGTGGCC 480 TCCTACGTAG AGGGCGGTGG AGGCTCCCCG GGTGAACCGT CTGGTCCAAT CTCTACTATC 540 AACCCGTCTC CTCCGTCTAA AGAATCTCAT AAATCTCCAA ACATGGCTAA CTGCTCTATA 600 ATGATCGATG AAATTATACA TCACTTAAAG AGACCACCTA ACCCTTTGCT GGACCCGAAC 660 AACCTCAATT CTGAAGACAT GGATATCCTG ATGGAACGAA ACCITCGAAC TCCAAACCTG 720 CTCGCATTCG TAAGGGCTGT CAAGCACTTA GAAAATGCAT CAGGTAHGA GGCAATTCTT 780 CGTAATCTCC AACCATGTCT GCCCTCTGCC ACGGCCGCAC CCTCTCGACA TCCAATCATC 840 ATCAAGGCAG GTGACTGGCA AGAATTCCGG GAAAAACTGA CGTTCTATCT GGTTACCCTT 900 GAGCAAGCGC AGGAACAACA G 921 (2)序列編號NO·· 234資料 : (i)序列特性： (A)長度：921鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 234 GCGCTGCAGG ATGAAGAGCT GTGTGGCGGC CTCTGGCGGC TGGTCCTGGC ACAGCGCTTG 60 ATGGAGCGGC TCAAGACTGT CGCTGGGTCC AAGATGCAAG GCTTGCTGGA GCGCGTGAAC 120 ACGGAGATAC ACTTTGTCAC CAAATGTGCC TTTCAGCCCC CCCCCAGCTG TCTTCGCTTC 180 GTCCAGACCA ACATCTCCCG CCTCCTGCAG GAGACCTCCG AGCAGCTGGT GGCGCTGAAG 240 CCCTGGATCA CTCGCCAGAA CTTCTCCCGG TGCCTGGAGC TGCAGTGTCA GCCCGACTCC 300 TCAACCCTGG GCGGTGGGTC AGGAGGTGGG TCAGGAGGTG GATCCGGAGG TGGCTCAGGG 360 GGAGGTAGTG GTACCCAGGA CTGCTCCTTC CAACACAGCC CCATCTCCTC CGACTTCGCT 420 GTCAAAATCC GTGAGCTGTC TGACTACCTG CTTCAAGATT ACCCAGTCAC CGTGGCCTCC 480 AACTACGTAG AGGGCGGTGG AGGCTCCCCG GGTGAACCGT CTGGTCCAAT CTCTACTATC 540 AACCCGTCTC CTCCGTCTAA AGAATCTCAT AAATCTCCAA ACATGGCTAA CTGCTCTATA 600 ATGATCGATG AAATTATACA TCACTTAAAG AGACCACCTA ACCCTTTGCT GGACCCGAAC 660

O:\92\92747.DOC -131- 200413407 AACCTCAATT CTGAAGACAT GGATATCCTG ATGGAACGAA ACCITCGAAC TCCAAACCTG 720 CTCGCATTCG TAAGGGCTGT CAAGCACTTA GAAAATGCAT CAGGTATTGA GGCAATTCTT 780 CGTAATCTCC AACCATGTCT GCCCTCTGCC ACGGCCGCAC CCTCTCGACA TCCAATCATC 840 ATCAAGGCAG GTGACTGGCA AGAATTCCGG GAAAAACTGA CGTTCTATCT GGmCCCTT 900 GAGCAAGCGC AGGAACAACA G 921 (2)序列編號NO: 235資料 • (i)序列特性： (A)長度：921鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 235 GCGCAAGATG AGGAACTGTG TGGTGGTCTC TGGCGGCTGG TCCTGGCACA GCGCTGGATG 60 GAGCGGCTCA AGACTGTCGC TGGGTCCAAG ATGCMGGCT TGCTGGAGCG CGTGAACACG 120 GAGATACACT TTGTCACCAA ATGTGCCTTT CAGCCCCCCC CCAGCTGTCT TCGCTTCGTC 180 CAGACCAACA TCTCCCGCCT CCTGCAGGAG ACCTCCGAGC AGCTGGTGGC GCTGAAGCCC 240 TGGATCACTC GCCAGAACTT CTCCCGGTGC CTGGAGCTGC AGTGTCAGCC CGACTCCTCA 300 ACCCTGGGCG GTGGGTCAGG AGGTGGGTCA GGAGGTGGAT CCGGAGGTGG CTCAGGGGGA 360 GGTAGTGGTA CCCAGGACTG CTCCTTCCAA CACAGCCCCA TCTCCTCCGA CTTCGCTGTC 420 AAAATCCGTG AGCTGTCTGA CTACCTGCIT CAAGATTACC CAGTCACCGT GGCCTCCAAC 480 CTGTACGTAG AGGGCGGTGG AGGCTCCCCG GGTGAACCGT CTGGTCCAAT CTCTACTATC 540 AACCCGTCTC CCCCGTCTAA AGAATCTCAT AAATCTCCAA ACATGGCTAA CTGCTCTATA 600 ATGATCGATG AAATTATACA TCACITAAAG AGACCACCTA ACCCTTTGCT GGACCCGAAC 660 AACCTCAATT CTGAAGACAT GGATATCCTG ATGGAACGAA ACCTTCGAAC TCCAAACCTG 720 CTCGCATTCG TAAGGGCTGT CAAGCACTTA GAAAATGCAT CAGGTATTGA GGCAATTCTT 780 CGTAATCTCC AACCATGTCT GCCCTCTGCC ACGGCCGCAC CCTCTCGACA TCCAATCATC 840 ATCAAGGCAG GTGACTGGCA AGAATTCCGG GAAAAACTGA CGTTCTATCT gg™ccctt 900 GAGCAAGCGC AGGAACAACA G 921 (2)序列編號NO: 236資料 • (i)序列特性： (A)長度：921鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 236 GCTGAAGAAC TGTGTGGTGG CCTGTGGCGG CTGGTCCTGG CACAGCGCTG GATGGAGCGG 60 CTCAAGACTG TCGCTGGGTC CAAGATGCAA GGCTTGCTGG AGCGCGTGAA CACGGAGATA 120 CACTTTGTCA CCAAATGTGC CTTTCAGCCC CCCCCCAGCT GTCTTCGCTT CGTCCAGACC 180 O:\92\92747.DOC -132- 200413407 AACATCTCCC GCCTCCTGCA GGAGACCTCC GAGCAGCTGG TGGCGCTGAA GCCCTGGATC 240 ACTCGCCAGA ACTTCTCCCG GTGCCTGGAG CTGCAGTGTC AGCCCGACTC CTCAACCCTG 300 GGCGGTGGGT CAGGAGGTGG GTCAGGAGGT GGATCCGGAG GTGGCTCAGG GGGAGGTAGT 360 GGTACCCAGG ACTGCTCCTT CCAACACAGC CCCATCTCCT CCGACTTCGC TGTCAAAATC 420 CGTGAGCTGT CTGACTACCT GCTTCAAGAT TACCCAGTCA CCGTGGCCTC CAACCTGCAG 480 GACTACGTAG AGGGCGGTGG AGGCTCCCCG GGTGAACCGT CTGGTCCAAT CTCTACTATC 540 AACCCGTCTC CTCCGTCTAA AGAATCTCAT AAATCTCCAA ACATGGCTAA CTGCTCTATA 600 ATGATCGATG AAAmTACA TCACTTAAAG AGACCACCTA ACCCTTTGCT GGACCCGAAC 660 AACCTCAATT CTGAAGACAT GGATATCCTG ATGGAACGAA ACCITCGAAC TCCAAACCTG 720 CTCGCATTCG TAAGGGCTGT CAAGCACTTA GAAAATGCAT CAGGTATTGA GGCAATTCTT 780 CGTAATCTCC AACCATGTCT GCCCTCTGCC ACGGCCGCAC CCTCTCGACA TCCAATCATC 840 ATCAAGGCAG GTGACTGGCA AGAATTCCGG GAAAAACTGA CGTTCTATCT GGTTACCCIT 900 GAGCAAGCGC AGGAACAACA G 921 (2)序列編號NO: 237資料； (i)序列特性： (A)長度：921鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 237 GCTCTGTGCG GTGGCCTGTG GCGTCTGGTC CTGGCACAGC GCTGGATGGA GCGGCTCAAG 60 ACTGTCGCTG GGTCCAAGAT GCAAGGCTTG CTGGAGCGCG TGAACACGGA GATACACTTT 120 GTCACCAAAT GTGCCTTTCA GCCCCCCCCC AGCTGTCTTC GCTTCGTCCA GACCAACATC 180 TCCCGCCTCC TGCAGGAGAC CTCCGAGCAG CTGGTGGCGC TGAAGCCCTG GATCACTCGC 240 CAGAACTTCT CCCGGTGCCT GGAGCTGCAG TGTCAGCCCG ACTCCTCAAC CCTGGGCGGT 300 GGGTCAGGAG GTGGGTCAGG AGGTGGATCC GGAGGTGGCT CAGGGGGAGG TAGTGGTACC 360 CAGGACTGCT CCTTCCAACA CAGCCCCATC TCCTCCGACT TCGCTGTCAA AATCCGTGAG 420 CTGTCTGACT ACCTGCTTCA AGAmCCCA GTCACCCTGG CCTCCAACCT GCAGGACGAG 480 GAGTACGTAG AGGGCGGTGG AGGCTCCCCG GGTGAACCGT CTGGTCCAAT CTCTACTATC 540 AACCCGTCTC CTCCGTCTAA AGAATCTCAT AAATCTCCAA ACATGGCTAA CTGCTCTATA 600 ATGATCGATG AAATTATACA TCACTTAAAG AGACCACCTA ACCCITTGCT GGACCCGAAC 660 AACCTCAATT CTGAAGACAT GGATATCCTG ATGGAACGAA ACCTTCGAAC TCCAAACCTG 720 CTCGCATTCG TAAGGGCTGT CAAGCACTTA GAAAATGCAT CAGGTATTGA GGCMITCTT 780 CGTAATCTCC AACCATGTCT GCCCTCTGCC ACGGCCGCAC CCTCTCGACA TCCAATCATC 840 ATCAAGGCAG GTGACTGGCA AGAATTCCGG GAAAAACTGA CGTTCTATCT GGmCCCTT 900 GAGCAAGCGC AGGAACAACA G 921 (2)序列編號NO: 238資料：

⑴序列特性： (A)長度： :921鹼基對 (B)形式： :核酸 (C)股數： :單 O:\92\92747.DOC • 133- 200413407 (D)拓撲結構：線形 (xi)序列描述：序列編號NO: 238 GCACTGTGTG GTGGTCTGTG GCGTCTGGTC CTGGCACAGC GCTGGATGGA GCGGCTCAAG 60 ACTGTCGCTG GGTCCAAGAT GCAAGGCTTG CTGGAGCGCG TGAACACGGA GATACACHT 120 GTCACCAAAT GTGCCTTTCA GCCCCCCCCC AGCTGTCTTC GCTTCGTCCA GACCAACATC 180 TCCCGCCTCC TGCAGGAGAC CTCCGAGCAG CTGGTGGCGC TGAAGCCCTG GATCACTCGC 240 CAGAACTTCT CCCGGTGCCT GGAGCTGCAG TGTCAGCCCG ACTCCTCAAC CCTGGGCGGT 300 GGGTCAGGAG GTGGGTCAGG AGGTGGATCC GGAGGTGGCT CAGGGGGAGG TAGTGGTACC 360 CAGGACTGCT CCTTCCAACA CAGCCCCATC TCCTCCGACT TCGCTGTCAA AATCCGTGAG 420 CTGTCTGACT ACCTGCITCA AGATTACCCA GTCACCGTGG CCTCCAACCT GCAGGACGAG 480 GAGTACGTAG AGGGCGGTGG AGGCTCCCCG GGTGAACCGT CTGGTCCAAT CTCTACTATC 540 AACCCGTCTC CTCCGTCTAA AGAATCTCAT AAATCTCCAA ACATGGCTAA CTGCTCTATA 600 ATGATCGATG AAATTATACA TCACTTAAAG AGACCACCTA ACCCHTGCT GGACCCGAAC 660 AACCTCAATT CTGAAGACAT GGATATCCTG ATGGAACGAA ACCTTCGAAC TCCAAACCTG 720 CTCGCAITCG TAAGGGCTGT CAAGCACTTA GAAAATGCAT CAGGTATTGA GGCAATTCTT 780 CGTAATCTCC AACCATGTCT GCCCTCTGCC ACGGCCGCAC CCTCTCGACA TCCAATCATC 840 ATCAAGGCAG GTGACTGGCA AGAATTCCGG GAAAAACTGA CGTTCTATCT GGmCCCTT 900 GAGCAAGCGC AGGAACAACA G 921 (2)序列編號NO: 239資料 • (i)序列特性： (A)長度：921鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 239 GCTCTGTGTG GCGGTCTGTG GCGTCTGGTC CTGGCACAGC GCTGGATGGA GCGGCTCAAG 60 ACTGTCGCTG GGTCCAAGAT GCAAGGCTTG CTGGAGCGCG TGAACACGGA GATACACHT 120 GTCACCAAAT GTGCCTTTCA GCCCCCCCCC AGCTGTCTTC GCTTCGTCCA GACCAACATC 180 TCCCGCCTCC TGCAGGAGAC CTCCGAGCAG CTGGTGGCGC TGAAGCCCTG GATCACTCGC 240 CAGAACTTCT CCCGGTGCCT GGAGCTGCAG TGTCGGCCCG ACTCCTCAAC CCTGGGCGGT 300 GGGTCAGGAG GTGGGTCAGG AGGTGGATCC GGAGGTGGCT CAGGGGGAGG TAGTGGTACC 360 CAGGACTGCT CCTTCCAACA CAGCCCCATC TCCTCCGACT TCGCTCTCAA GATCCGTGAG 420 CTGTCTGACT ACCTGCTTCA AGATTACCCA GTCACCGTGG CCTCCAACCT GCAGGACGAG 480 GAGTACGTAG AGGGCGGTGG AGGCTCCCCG GGTGAACCGT CTGGTCCAAT CTCTACTATC 540 AACCCGTCTC CTCCGTCTAA AGAATCTCAT AAATCTCCAA ACATGGCTAA CTGCTCTATA 600 ATGATCGATG AAATTATACA TCACTTAAAG AGACCACCTA ACCCTTTGCT GGACCCGAAC 660 MCCTCMTT CTGAAGACAT GGATATCCTG ATGGAACGAA ACCTTCGAAC TCCAAACCTG 720 CTCGCATTCG TAAGGGCTGT CAAGCACTTA GAAAATGCAT CAGGTATTGA GGCAATTCTT 780 CGTAATCTCC AACCATGTCT GCCCTCTGCC ACGGCCGCAC CCTCTCGACA TCCAATCATC 840 ATCAAGGCAG GTGACTGGCA AGMTTCCGG GAAAAACTGA CGTTCTATCT GGmCCCTT 900 GAGCAAGCGC AGGAACAACA G 921 200413407 (2)序列編號NO: 240資料： (i)序列特性： (A) 長度：903鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 240 GCCTCCAAGA TGCAAGGCTT GCTGGAGCGC GTGAACACGG AGATACACTT TGTCACCAAA 60 TGTGCCTTTC AGCCCCCCCC CAGCTGTCTT CGCTTCGTCC AGACCAACAT CTCCCGCCTC 120 CTGCAGGAGA CCTCCGAGCA GCTGGTGGCG CTGAAGCCCT GGATCACTCG CCAGAACTTC 180 TCCCGGTGCC TGGAGCTGCA GTGTCAGCCC GACTCCTCAA CCCTCGGCGG TGGGTCAGGA 240 GGTGGGTCAG GAGGTGGATC CGGAGGTGGC ACCCAGGACT GCTCCTTCCA ACACAGCCCC 300 ATCTCCTCCG ACTTCGCTGT CAAAATCCGT GAGCTGTCTG ACTACCTGCT TCAAGATTAC 360 CCAGTCACCG TGGCCTCCAA CCTGCAGGAC GAGGAGCTCT GCGGGGGCCT CTGGCGGCTG 420 GTCCTGGCAC AGCGCTGGAT GGAGCGGCTC AAGACTGTCG CTGGCTACGT AGAGGGCGGT 480 GGAGGCTCCC CGGGTGAACC GTCTGGTCCA ATCTCTACTA TCAACCCGTC TCCTCCGTCT 540 AAAGAATCTC ATAAATCTCC AAACATGGCT AACTGCTCTA TAATGATCGA TGAAATTATA 600 CATCACTTAA AGAGACCACC TAACCCTTTG CTGGACCCGA ACAACCTCAA TTCTGAAGAC 660 ATGGATATCC TGATGGAACG AAACCTTCGA ACTCCAAACC TGCTCGCm CGTAAGGGCT 720 GTCAAGCACT TAGAAAATGC ATCAGGTATT GAGGCAATTC TTCGTAATCT CCAACCATGT 780 CTGCCCTCTG CCACGGCCGC ACCCTCTCGA CATCCAATCA TCATCAAGGC AGGTGACTGG 840 CAAGAATTCC GGGAAAAACT GACGTTCTAT CTGGmCCC TTGAGCAAGC GCAGGAACAA 900 CAG 903 (2)序列編號NO: 241資料 (i)序列特性： (A)長度：945鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 241 GCTCAAGATG ATGAGCTGTG TGGTGGTCTC TGGCGGCTGG TCCTGGCACA GCGCTGGATG 60 GAGCGGCTCA AGACTGTCGC TGC3GTCCAAG ATGCAAGGCT TGCTGGAGCG CGTGAACACG 120 GAGATACACT TTGTCACCAA ATGTGCCITT CAGCCCCCCC CCAGCTGTCT TCGCTTCGTC 180 CAGACCAACA TCTCCCGCCT CCTGCAGGAG ACCTCCGAGC AGCTGGTGGC GCTGAAGCCC 240 TGGATCACTC GCCAGAACTT CTCCCGGTGC CTGGAGCTGC AGTGTCAGCC CGACTCCTCA 300 ACCCTGGGCG GTGGGTCAGG AGGTGGGTCA GGCGGTGCTT CTGGCGGAGG ATCCGGCGGC 360 GGAAGCGGAG GTGGCTCTGG GGGAGGTAGT GGTACCCAGG ACTGCTCCTT CCAACACAGC 420 CCCATCTCCT CCGACTTCGC TGTCAAAATC CGTGAGCTGT CTGACTACCT GCTTCAAGAT 480 TACCCAGTCA CCGTGGCCTC CAACCTGTAC GTAGAGGGCG GTGGAGGCTC CCCGGGTGAA 540 O:\92\92747.DOC -135- 200413407 CCGTCTGGTC CAATCTCTAC TATCAACCCG CCAAACATGG CTAACTGCTC TATAATGATC CCTAACCCTT TGCTGGACCC GAACAACCTC CGAAACCTTC GAACTCCAAA CCTGCTCGCA GCATCAGGTA TTGAGGCAAT TCTTCGTAAT GCACCCTCTC GACATCCAAT CATCATCAAG CTGACGTTCT ATCTGGTTAC CCTTGAGCAA (2)序列編號NO: 242資料 TCTCCTCCGT CTAAAGAATC TCATAAATCT 600 GATGAAATTA TACATCACTT AAAGAGACCA 660 AATTCTGAAG ACATGGATAT CCTGATGGAA 720 TTCGTAAGGG CTGTCAAGCA CTTAGAAAAT 780 CTCCAACCAT GTCTGCCCTC TGCCACGGCC 840 GCAGGTGACT GGCAAGAATT CCGGGAAAAA 900 GCGCAGGAAC AACAG 945 ⑴序列特性： (A) 長度：903鹼基對 (B) 形式：核酸 (C)股數：單 (D)拓撲結構：線形

〇i)序列描述： GCCCAAGATG AAGAACTGTG GAGCGGCTCA AGACTGTCGC GAGATACACT TTCTCACCAA CAGACCAACA TCTCCCGCCT TGGATCACTC GCCAGAACTT ACCCTGCCGC CACCGTGGAG TGCTCCITCC AACACAGCCC GACTACCTGC TTCMGAm GGAGGCTCCC CGGGTGAACC AAAGAATCTC ATAAATCTCC CATCACTTAA AGAGACCACC ATGGATATCC TGATGGAACG GTCAAGCACT TAGAAAATGC CTGCCCTCTG CCACGGCCGC CAAGAATTCC GGGAAAAACT CAG

序列編號NO: 242 TGGTGGCCTC TGGCGGCTGG TGGGTCCAAG ATGCAAGGCT ATGTGCCrTT CAGCCCCCCC CCTGCAGGAG ACCTCCGAGC CTCCCGGTGC CTGGAGCTGC CCCGCGTCCA CTCGGCGCCA CATCTCCTCC GACTTCGCTG CCCAGTCACC GTGGCCTCCA GTCTGGTCCA ATCTCTACTA AAACATGGCT AACTGCTCTA TAACCCTTTG CTGGACCCGA AAACCTTCGA ACTCCAAACC ATCAGGTATT GAGGCAATTC ACCCTCTCGA CATCCAATCA GACGTTCTAT CTGGTTACCC TCCTGGCACA GCGCTGGATG 60 TGCTGGAGCG CGTGAACACG 120 CCAGCTGTCT TCGCITCGTC 180 AGCTGGTGGC GCTGAAGCCC 240 AGTGTCAGCC CGACTCCTCA 300 CCGCACCGAC CACCCAGGAC 360 TCAAAATCCG TGAGCTGTCT 420 ACCTGTACGT AGAGGGCCGT 480 TCAACCCGTC TCCTCCGTCT 540 TAATGATCGA TGAAATTATA 600 ACAACCTCAA TTCTGAAGAC 660 TGCTCGCATT CGTAAGGGCT 720 TTCGTAATCT CCAACCATGT 780 TCATCAAGGC AGGTGACTGG 840 TTGAGCAAGC GCAGGAACAA 900 903 (2)序列編號NO: 243資料： (i)序列特性： (A) 長度：921鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 243 GCCCAAGATG AAGAACTGTG TGGTGGCCTC TGGCGGCTGG TCCTGGCACA GCGCTGGATG 60 O:\92\92747.DOC -136- 200413407 GAGCGGCTCA AGACTGTCGC TGGGTCCAAG ATGCAAGGCT GAGATACACT TTGTCACCAA ATGTGCCTTT CAGCCCCCCC CAGACCAACA TCTCCCGCCT CCTGCAGGAG ACCTCCGAGC TGGATCACTC GCCAGAACTT CTCCCGGTGC CTGGAGCTGC ACCCTGCCGC CACCGTGGAG CCCGCGTCCA CTCGGCGCCA CCGCCTCTGA CCCAGGACTG CTCCTTCCAA CACAGCCCCA AAAATCCGTG AGCTGTCTGA CTACCTGCTT CAAGATTACC CTGTACGTAG AGGGCGGTGG AGGCTCCCCG GGTGAACCGT AACCCGTCTC CTCCGTCTAA AGAATCTCAT AAATCTCCAA ATGATCGATG AAATTATACA TCACITAAAG AGACCACCTA AACCTCAAIT CTGAAGACAT GGATATCCTG ATGGAACGAA CTCGCATTCG TAAGGGCTGT CAAGCACTTA GAAAATGCAT CGTAATCTCC AACCATGTCT GCCCTCTGCC ACGGCCGCAC ATCAAGGCAG GTGACTGGCA AGAATTCCGG GAAAAACTGA GAGCAAGCGC AGGAACAACA G (2)序列編號NO·· 244資料 ⑴序列特性： TGCTGGAGCG CGTGAACACG 120 CCAGCTGTCT TCGCTTCGTC 180 AGCTGGTGGC GCTGAAGCCC 240 AGTGTCAGCC CGACTCCTCA 300 CCGCACCGAC CGCTGGACAA 360 TCTCCTCCGA CTTCGCTGTC 420 CAGTCACCGT GGCCTCCAAC 480 CTGGTCCAAT CTCTACTATC 540 ACATGGCTAA CTGCTCTATA 600 ACCCTTTGCT GGACCCGAAC 660 ACCTTCGAAC TCCAAACCTG 720 CAGGTAHGA GGCAATTCTT 780 CCTCTCGACA TCCAATCATC 840 CGTTCTATCT GGmCCCTT 900 921

(A) 長度：1110鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 244 GCTACACCAT TGGGCCCTGC CAGCTCCCTG CCCCAGAGCT CAAGTGAGAA AGATCCAGGG CGATGGCGCA GCGCTCCAGG AAGCTGTGCC ACCCCGAGGA GCTGGTGCTG CTCGGACACT CCCCTGAGCT CCTGCCCCAG CCAGGCCCTG CAGCTGGCAG AGCGGCCTTT TCCTCTACCA GGGGCTCCTG CAGGCCCTGG GGTCCCACCT TGGACACACT GCAGCTGGAC GTCGCCGACT CAGATGGAAG AACTGGGAAT GGCCCCTGCC CTGCAGCCCA TTCGCCTCTG CTTTCCAGCG CCGGGCAGGA GGGGTCCTGG TTCCTGGAGC TGTCGTACCG CGTTCTACGC CACCTTGCGC GGAGGCTCCC CGGGTGAACC CTCTGGTCCA ATCTCTACTA AAAGAATCTC ATAAATCTCC AAACATGGCT GATGAAGAAC CTGGTCCTGG CACAGCGCTG GATGGAGCGG CTCAACACTG GGCTTGCTGG AGCGCGTGAA CACGGAGATA CACTITGTCA CCCCCCAGCT GTCTTCGCTT CGTCCAGACC AACATCTCCC GAGCAGCTGG TGGCGCTGAA GCCCTGGATC ACTCGCCAGA CTGCAGTGTC AGCCCGACTC CTCAACCCTG GGCGGTGGGT GGATCCGGAG GTGGCTCACG GGGAGGTAGT GGTACCCAGG CCCATCTCCT CCGACTTCGC TGTCAAAATC CGTGAGCTGT TACCCAGTCA CCGTGGCCTC CAACCTGCAG (2)序列編號NO: 245資料： ⑴序列特性： TCCTGCTCAA GTCTTTAGAG 60 AGAAGCTGTG TGCCACCTAC 120 CTCTGGGCAT CCCCTGCjGCT 180 GCTGCTTGAG CCAACTCCAT 240 AAGGGATATC CCCCGAGTTG 300 TTGCCACCAC CATCTGGCAG 360 CCCAGGGTGC CATGCCGGCC 420 TTGCTAGCCA TCTGCAGAGC 480 AGCCCTACGT AGAGGGCGGT 540 TCAACCCGTC TCCTCCGTCT 600 TGTGTGGTGG TCTGTGGCGG 660 TCGCTGGGTC CAAGATGCAA 720 CCAAATGTGC CTTTCAGCCC 780 GCCTCCTGCA GGAGACCTCC 840 ACTTCTCCCG GTGCCTGGAG 900 CAGGAGGTGG GTCAGGAGGT 960 ACTGCTCCIT CCAACACAGC 1020 CTGACTACCT GCTTCAAGAT 1080 1110

O:\92\92747.DOC -137- 200413407 (A) 長度：1110鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 245 GCTACACCAT TGGGCCCTGC CAGCTCCCTG CCCCAGAGCT TCCTGCTCAA GTCTTTAGAG 60 CAAGTGAGAA AGATCCAGGG CGATGGCGCA GCGCTCCAGG AGAAGCTGTG TGCCACCTAC 120 AAGCTGTGCC ACCCCGAGGA GCTGGTGCTG CTCGGACACT CTCTGGGCAT CCCCTGGGCT 180 CCCCTGAGCT CCTGCCCCAG CCAGGCCCTG CAGCTGGCAG GCTGCTTGAG CCAACTCCAT 240 AGCGGCCTTT TCCTCTACCA GGGGCTCCTG CAGGCCCTGG AAGGGATATC CCCCGAGTTG 300 GGTCCCACCT TGGACACACT GCAGCTGGAC GTCGCCGACT TTGCCACCAC CATCTGGCAG 360 CAGATGGAAG AACTGGGAAT GGCCCCTGCC CTGCAGCCCA CCCAGGGTGC CATGCCGGCC 420 TTCGCCTCTG CTTTCCAGCG CCGGGCAGGA GGGGTCCTGG HGCTAGCCA TCTGCAGAGC 480 TTCCTGGAGG TGTCGTACCG CGTTCTACGC CACCTTGCGC AGCCCTACGT AGAGGGCGGT 540 GGAGGCTCCC CGGGTGAACC GTCTGGTCCA ATCTCTACTA TCAACCCGTC TCCTCCGTCT 600 AAAGAATCTC ATAAATCTCC AAACATGGCA AATCTGCAAG ACGAGGAGCT GTGCGGGGGC 660 CTCTGGCGGC TGGTCCTGGC ACAGCGCTGG ATGGAGCGGC TCAAGACTGT CGCTGGGTCC 720 AAGATGCAAG GCTTGCTGGA GCGCGTGAAC ACGGAGATAC ACTTTGTCAC CAAATGTGCC 780 TTTCAGCCCC CCCCCAGCTG TCTTCGCTTC GTCCAGATCA ACATCTCCCG CCTCCTGCAG 840 GAGACCTCCG AGCAGCTGGT GGCGCTGAAG CCCTGGATCA CTCGCCAGAA CTTCTCCCGG 900 TGCCTGGAGC TGCAGTGTCA GCCCGACTCC TCAACCCTGG GCGGTGGGTC AGGAGGTGGG 960 TCAGGAGGTG GATCCGGAGG TGGCTCAGGG GGAGGTAGTG GTACCCAGGA CTGCTCCTTC 1020 CAACACAGCC CCATCTCCTC CGACITCGCT GTCAAAATCC GTGAGCTGTC TGACTACCTG 1080 CTTCAAGATT ACCCAGTCAC CGTGGCCTCC 1110 (2)序列編號NO: 246資料： ⑴序列特性： (A) 長度：1110鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 246 GCTACACCAT TGGGCCCTGC CAGCTCCCTG CCCCAGAGCT TCCTGCTCAA GTCTTTAGAG 60 CAAGTGAGAA AGATCCAGGG CGATGGCGCA GCGCTCCAGG AGAAGCTGTG TGCCACCTAC 120 AAGCTGTGCC ACCCCGAGGA GCTGGTGCTG CTCGGACACT CTCTGGGCAT CCCCTGGGCT 180 CCCCTGAGCT CCTGCCCCAG CCAGGCCCTG CAGCTGGCAG GCTGCTTGAG CCAACTCCAT 240 AGCGGCCTTT TCCTCTACCA GGGGCTCCTG CAGGCCCTGG AAGGGATATC CCCCGAGTTG 300 GGTCCCACCT TGGACACACT GCAGCTGGAC GTCGCCGACT TTGCCACCAC CATCTGGCAG 360 CAGATGGAAG AACTGGGAAT GGCCCCTGCC CTGCAGCCCA CCCAGGGTGC CATGCCGGCC 420 TTCGCCTCTG CTTTCCAGCG CCGGGCAGGA GGGGTCCTGG TTGCTAGCCA TCTGCAGAGC 480 TTCCTGGAGG TGTCGTACCG CGTTCTACGC CACCTTGCGC AGCCCTACGT AGAGGGCGGT 540 GGAGGCTCCC CGGGTGAACC GTCTGGTCCA ATCTCTACTA TCAACCCGTC TCCTCCGTCT 600 O:\92\92747.DOC -138 200413407 AAAGAATCTC ATAAATCTCC AAACATGGCC CCCCCCAGCT GTCTTCGCTT CGTCCAGACC 660 AACATCTCCC GCCTCCTGCA GGAGACCTCC GAGCAGCTGG TGGCGCTGAA GCCCTGGATC 720 ACTCGCCAGA ACTTCTCCCG GTGCCTGGAG CTGCAGTGTC AGCCCGACTC CTCAACCCTG 780 GGCGGTGGGT CAGGAGGTGG GTCAGGAGGT GGATCCGGAG GTGGCTCAGG GGGAGGTAGT 840 GGTACCCAGG ACTGCTCCTT CCAACACAGC CCCATCTCCT CCGACTTCGC TGTCAAAATC 900 CGTGAGCTGT CTGACTACCT GCTTCAAGAT TACCCAGTCA CCGTGGCCTC CAACCTGCAG 960 GACGAGGAGC TCTGCGGGGG CCTCTGGCGG CTGGTCCTGG CACAGCGCTG GATGGAGCGG 1020 CTCAAGACTG TCGCTGGGTC CAAGATGCAA GGCTTGCTGG AGCGCGTGAA CACGGAGATA 1080 CACTTTGTCA CCAAATGTGC CTTTCAGCCC 1110 (2)序列編號ΝΟ_· 247資料： (i)序列特性： (A) 長度：1110鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 247 GCTACACCAT TGGGCCCTGC CAGCTCCCTG CCCCAGAGCT TCCTGCTCAA GTCITTAGAG 60 CAAGTGAGAA AGATCCAGGG CGATGGCGCA GCGCTCCAGG AGAAGCTGTG TGCCACCTAC 120 AAGCTGTGCC ACCCCGAGGA GCTGGTGCTG CTCGGACACT CTCTGGGCAT CCCCTGGGCT 180 CCCCTGAGCT CCTGCCCCAG CCAGGCCCTG CAGCTGGCAG GCTGCTTGAG CCAACTCCAT 240 AGCGGCCTTT TCCTCTACCA GGGGCTCCTG CAGGCCCTGG AAGGGATATC CCCCGAGTTG 300 GGTCCCACCT TGGACACACT GCAGCTGGAC GTCGCCGACT TTGCCACCAC CATCTGGCAG 360 CAGATGGAAG AACTGGGAAT GGCCCCTGCC CTGCAGCCCA CCCAGGGTGC CATGCCGGCC 420 TTCGCCTCTG CTTTCCAGCG CCGGGCAGGA GGGGTCCTGG TTGCTAGCCA TCTGCAGAGC 480 TTCCTGGAGG TGTCGTACCG CGTTCTACGC CACCTTGCGC AGCCCTACGT AGAGGGCGGT 540 GGAGGCTCCC CGGGTGAACC GTCTGGTCCA ATCTCTACTA TCAACCCGTC TCCTCCGTCT 600 AAAGAATCTC ATAAATCTCC AAACATGGCT CTGCAGGATG AGGAACTGTG CGGCGGCCTC 660 TGGGGGCTGG TCCTGGCACA GCGCTGGATG GAGCGGCTCA AGACTGTCGC TGGGTCCAAG 720 ATGCAAGGCT TGCTGGAGCG CGTGAACACG GAGATACACT TTGTCACCAA ATGTGCCTTT 780 CAGCCCCCCC CCAGCTGTCT TCGCTTCGTC CAGACCAACA TCTCCCGCCT CCTGCAGGAG 840 ACCTCCGAGC AGCTGGTGGC GCTGaXGCCC TGGATCACTC GCCAGAACTT CTCCCGGTGC 900 CTGGAGCTGC AGTGTCAGCC CGACTCCTCA ACCCTGGGCG GTGGGTCAGG AGGTGGGTCA 960 GGAGGTGGAT CCGGAGGTGG CTCAGGGGGA GGTAGTGGTA CCCAGGACTG CTCCTTCCAA 1020 CACAGCCCCA TCTCCTCCGA CTTCGCTGTC AAAATCCGTG AGCTGTCTGA CTACCTGCTT 1080 CAAGAmCC CAGTCACCGT GGCCTCCAAC 1110 (2)序列編號NO: 248資料 1 (i)序列特性： (A) 長度：1110鹼基對 (B) 形式：核酸 (C) 股數：單 O:\92\92747.DOC -139- 200413407 (D)拓撲結構：線形 (xi)序列描述：序列編號NO: 248 GCTACACCAT TGGGCCCTGC CAGCTCCCTG CCCCAGAGCT TCCTGCTCAA GTCTTTAGAG 60 CAAGTGAGAA AGATCCAGGG CGATGGCGCA GCGCTCCAGG AGAAGCTGTG TGCCACCTAC 120 AAGCTGTGCC ACCCCGAGGA GCTGGTGCTG CTCGGACACT CTCTGGGCAT CCCCTGGGCT 180 CCCCTGAGCT CCTGCCCCAG CCAGGCCCTG CAGCTGGCAG GCTGCTTGAG CCAACTCCAT 240 AGCGGCCm TCCTCTACCA GGGGCTCCTG CAGGCCCTGG AAGGGATATC CCCCGAGTTG 300 GGTCCCACCT TGGACACACT GCAGCTGGAC GTCGCCGACT nGCCACCAC CATCTGGCAG 360 CAGATGGAAG AACTGGGAAT GGCCCCTGCC CTGCAGCCCA CCCAGGGTGC CATGCCGGCC 420 TTCGCCTCTG CTTTCCAGCG CCGGGCAGGA GGGGTCCTGG TTGCTAGCCA TCTGCAGAGC 480 TTCCTGGAGG TGTCGTACCG CGTTCTACGC CACCTTGCGC AGCCCTACGT AGAGGGCGGT 540 GGAGGCTCCC CGGGTGAACC GTCTGGTCCA ATCTCTACTA TCAACCCGTC TCCTCCGTCT 600 AAAGAATCTC ATAAATCTCC AAACATGGCT CAAGATGAAG AGCTGTGTGG TGGTCTCTGG 660 CGGCTGGTCC TGGCACAGCG CTGGATGGAG CGGCTCAAGA CTGTCGCTGG GTCCAAGATG 720 CAAGGCTTGC TGGAGCGCGT GAACACGGAG ATACACTTTG TCACCAAATG TGCCTTTCAG 780 CCCCCCCCCA GCTGTCTTCG CTTCGTCCAG ACCAACATCT CCCGCCTCCT GCAGGAGACC 840 TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG ATCACTCGCC AGAACTTCTC CCGGTGCCTG 900 GAGCTGCAGT GTCAGCCCGA CTCCTCAACC CTGGGCGGTG GGTCAGGAGG TGGGTCAGGA 960 GGTGGATCCG GAGGTGGCTC AGGGGGAGGT AGTGGTACCC AGGACTGCTC CTTCCAACAC 1020 AGCCCCATCT CCTCCGACTT CGCTGTCAAA ATCCGTGAGC TGTCTGACTA CCTGCTTCAA 1080 GATTACCCAG TCACCGTGGC CTCCAACCTG 1110 (2)序列編號NO: 249資料： (i)序列特性： (A) 長度：1110鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 249 GCTACACCAT TGGGCCCTGC CAGCTCCCTG CCCCAGAGCT TCCTGCTCAA GTCTTTAGAG 60 CAAGTGAGAA AGATCCAGGG CGATGGCGCA GCGCTCCAGG AGAAGCTGTG TGCCACCTAC 120 AAGCTGTGCC ACCCCGAGGA GCTGGTGCTG CTCGGACACT CTCTGGGCAT CCCCTGGGCT 180 CCCCTGAGCT CCTGCCCCAG CCAGGCCCTG CAGCTGGCAG GCTGCTTGAG CCAACTCCAT 240 AGCGGCCm TCCTCTACCA GGGGCTCCTG CAGGCCCTGG AAGGGATATC CCCCGMHTG 300 GGTCCCACCT TGGACACACT GCAGCTGGAC GTCGCCGACT TTGCCACCAC CATCTGGCAG 360 CAGATGGAAG AACTGGGAAT GGCCCCTGCC CTGCAGCCCA CCCAGGGTGC CATGCCGGCC 420 TTCGCCTCTG CTTTCCAGCG CCGGGCAGGA GGGGTCCTGG TTGCTAGCCA TCTGCAGAGC 480 nCCTGGAGG TGTCGTACCG CGTTCTACGC CACCTTGCGC AGCCCTACGT AGAGGGCGGT 540 GGAGGCTCCC CGGGTGAACC GTCTGGTCCA ATCTCTACTA TCAACCCGTC TCCTCCGTCT 600 AAAGAATCTC ATAAATCTCC AAACATGGCT GAAGAACTGT GTGGTGGTCT GTGGCGGCTG 660 GTCCTGGCAC AGCGCTGGAT GGAGCGGCTC AAGACTGTCG CTGGGTCCAA GATGCAAGGC 720 TTGCTGGAGC GCGTGAACAC GGAGATACAC TTTGTCACCA AATGTGCCTT TCAGCCCCCC 780 CCCAGCTGTC TTCGCTTCGT CCAGACCAAC ATCTCCCGCC TCCTGCAGGA GACCTCCGAG 840 CAGCTGGTGG CGCTGAAGCC CTGGATCACT CGCCAGAACT TCTCCCGGTG CCTGGAGCTG 900 200413407 CAGTGTCAGC CCGACTCCTC AACCCTGGGC GGTGGGTCAG GAGGTGGCTC AGGAGGTGGA 960 TCCGGAGGTG GCTCAGGGGG AGGTAGTGGT ACCCAGGACT GCTCCTTCCA ACACAGCCCC 1020 ATCTCCTCCG ACTTCGCTGT CAAAATCCGT GAGCTGTCTG ACTACCTGCT TCAAGATTAC 1080 CCAGTCACCG TGGCCTCCAA CCTGCAGGAC 1110 (2)序列編號NO: 250資料： (i)序列特性： (A)長度：1110鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 250 GCTACACCAT TGGGCCCTGC CAGCTCCCTG CCCCAGAGCT TCCTGCTCAA GTCTTTAGAG 60 CAACTGAGAA AGATCCAGGG CGATGGCGCA GCGCTCCAGG AGAAGCTGTG TGCCACCTAC 120 AAGCTGTGCC ACCCCGAGGA GCTGGTGCTG CTCGGACACT CTCTGGGCAT CCCCTGGGCT 180 CCCCTGAGCT CCTGCCCCAG CCAGGCCCTG CAGCTGGCAG GCTGCTTGAG CCAACTCCAT 240 AGCGGCCTTT TCCTCTACCA GGGGCTCCTG CAGGCCCTGG AAGGGATATC CCCCGAGTTG 300 GGTCCCACCT TGGACACACT GCAGCTGGAC GTCGCCGACT HGCCACCAC CATCTGGCAG 360 CAGATGGAAG AACTGGGAAT GGCCCCTGCC CTGCAGCCCA CCCAGGGTGC CATGCCGGCC 420 TTCGCCTCTG CTTTCCAGCG CCGGGCAGGA GGGGTCCTGG nGCTAGCCA TCTGCAGAGC 480 TTCCTGGAGG TGTCGTACCG CGTTCTACGC CACCTTGCGC AGCCCTACGT AGAGGGCGGT 540 GGAGGCTCCC CGGGTGAACC GTCTGGTCCA ATCTCTACTA TCAACCCGTC TCCTCCGTCT 600 AAAGAATCTC ATAAATCTCC AAACATGGCT GAGCTGTGTG GTGGCCTGTG GCGTCTGGTC 660 CTGGCACAGC GCTGGATGGA GCGGCTCAAG ACTGTCGCTG GGTCCAAGAT GCAAGGCTTG 720 CTGGAGCGCG TGAACACGGA GATACACTTT GTCACCAAAT GTGCCTTTCA GCCCCCCCCC 780 AGCTGTCTTC GCTTCGTCCA GACCAACATC TCCCGCCTCC TGCAGGAGAC CTCCGAGCAG 840 CTGGTGGCGC TGAAGCCCTG GATCACTCGC CAGAACTTCT CCCGGTGCCT GGAGCTGCAG 900 TGTCAGCCCG ACTCCTCAAC CCTGGGCGGT GGGTCAGGAG GTGGGTCAGG AGGTGGATCC 960 GGAGGTGGCT CAGGGGGAGG TAGTGGTACC CAGGACTGCT CCTTCCAACA CAGCCCCATC 1020 TCCTCCGACT TCGCTGTCAA AATCCGTGAG CTGTCTGACT ACCTGCTTCA AGAmCCCA 1080 GTCACCGTGG CCTCCAACCT GCAGGACGAG 1110 (2)序列編號NO: 251資料 : (i)序列特性： (A)長度：1110鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO·. 251 GCTACACCAT TGGGCCCTGC CAGCTCCCTG CCCCAGAGCT TCCTGCTCAA GTCTTTAGAG 60 O:\92\92747.DOC 141- 200413407 CAAGTGAGAA AGATCCAGGG CGATGGCGCA GCGCTCCAGG AGAAGCTGTG TGCCACCTAC 120 AAGCTGTGCC ACCCCGAGGA GCTGGTGCTG CTCGGACACT CTCTGGGCAT CCCCTGGGCT 180 CCCCTGAGCT CCTGCCCCAG CCAGGCCCTG CAGCTGGCAG GCTGCTTGAG CCAACTCCAT 240 AGCGGCCTTT TCCTCTACCA GGGGCTCCTG CAGGCCCTGG AAGGGATATC CCCCGAGTTG 300 GGTCCCACCT TGGACACACT GCAGCTGGAC GTCGCCGACT TTGCCACCAC CATCTGGCAG 360 CAGATGGAAG AACTGGGAAT GGCCCCTGCC CTGCAGCCCA CCCAGGGTGC CATGCCGGCC 420 TTCGCCTCTG CTTTCCAGCG CCGGGCAGGA GGGGTCCTGG TTGCTAGCCA TCTGCAGAGC 480 TTCCTGGAGG TGTCGTACCG CGTTCTACGC CACCTTGCGC AGCCCTACGT AGAGGGCGGT 540 GGAGGCTCCC CGGGTGAACC GTCTGGTCCA ATCTCTACTA TCAACCCGTC TCCTCCGTCT 600 AAAGAATCTC ATAAATCTCC AAACATGGCT CTGTGCGGTG GTCTGTGGCG TCTGGTCCTG 660 GCACAGCGCT GGATGGAGCG GCTCAAGACT GTCGCTGGGT CCAAGATGCA AGGCTTGCTG 720 GAGCGCGTGA ACACGGAGAT ACACTTTGTC ACCAAATGTG CCTTTCAGCC CCCCCCCAGC 780 TGTCTTCGCT TCGTCCAGAC CAACATCTCC CGCCTCCTGC AGGAGACCTC CGAGCAGCTG 840 GTGGCGCTGA AGCCCTGGAT CACTCGCCAG AACTTCTCCC GGTGCCTGGA GCTGCAGTGT 900 CAGCCCGACT CCTCAACCCT GGGCGGTGGG TCAGGAGGTG GGTCAGGAGG TGGATCCGGA 960 GGTGGCTCAG GGGGAGGTAG TGGTACCCAG GACTGCTCCT TCCAACACAG CCCCATCTCC 1020 TCCGACTTCG CTGTCAAAAT CCGTGAGCTG TCTGACTACC TGCTTCAAGA TTACCCAGTC 1080 ACCGTGGCCT CCAACCTGCA GGACGAGGAG 1110 (2)序列編號NO·· 252資料： (i)序列特性： (A) 長度：1092鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 252 GCTACACCAT TGGGCCCTGC CAGCTCCCTG CCCCAGAGCT TCCTGCTCAA GTCTTTAGAG 60 CAAGTGAGAA AGATCCAGGG CGATGGCGCA GCGCTCCAGG AGAAGCTGTG TGCCACCTAC 120 AAGCTGTGCC ACCCCGAGGA GCTGGTGCTG CTCGGACACT CTCTGGGCAT CCCCTGGGCT 180 CCCCTGAGCT CCTGCCCCAG CCAGGCCCTG CAGCTGGCAG GCTGCTTGAG CCAACTCCAT 240 AGCGGCCTTT TCCTCTACCA GGGGCTCCTG CAGGCCCTGG AAGGGATATC CCCCGAGTTG 300 GGTCCCACCT TGGACACACT GCAGCTGGAC GTCGCCGACT TTGCCACCAC CATCTGGCAG 360 CAGATGGAAG AACTGGGAAT GGCCCCTGCC CTGCAGCCCA CCCAGGGTGC CATGCCGGCC 420 TTCGCCTCTG CTTTCCAGCG cCGGGCAGGA GGGGTCCTGG TTGCTAGCCA TCTGCAGAGC 480 TTCCTGGAGG TGTCGTACCG CGTTCTACGC CACCTTGCGC AGCCCTACGT AGAGGGCGGT 540 GGAGGCTCCC CGGGTGAACC GTCTGGTCCA ATCTCTACTA TCAACCCGTC TCCTCCGTCT 600 AAAGAATCTC ATAAATCTCC AAACATGGCT GATGAAGAAC TGTGTGGTGG GCTGTGGCGG 660 CTGGTCCTGG CACAGCGCTG GATGGAGCGG CTCAAGACTG TCGCTGGGTC CAAGATGCAA 720 GGCTTGCTGG AGCGCGTGAA CACGGAGATA CACTHGTCA CCAAATGTGC CTTTCAGCCC 780 CCCCCCAGCT GTCTTCGCTT CGTCCAGACC AACATCTCCC GCCTCCTGCA GGAGACCTCC 840 GAGCAGCTGG TGGCGCTGAA GCCCTGGATC ACTCGCCAGA ACTTCTCCCG GTGCCTGGAG 900 CTGCAGTGTC AGCCCGACTC CTCAACCCTG CCGCCACCGT GGAGCCCGCG TCCACTCGGC 960 GCCACCGCAC CGACCACCCA GGACTGCTCC TTCCAACACA GCCCCATCTC CTCCGACTTC 1020 GCTGTCAAAA TCCGTGAGCT GTCTGACTAC CTGCTTCAAG ATTACCCAGT CACCGTGGCC 1080 TCCAACCTGC AG 1092 (2)序列編號NO: 253資料： O:\92\92747.DOC -142- 200413407 ⑴序列特性： (A) 長度：1134鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 253 GCTACACCAT TGGGCCCTGC CAGCTCCCTG CCCCAGAGCT TCCTGCTCAA GTCTTTAGAG 60 CAAGTGAGAA AGATCCAGGG CGATGGCGCA GCGCTCCAGG AGAAGCTGTG TGCCACCTAC 120 AAGCTGTGCC ACCCCGAGGA GCTGGTGCTG CTCGGACACT CTCTGGGCAT CCCCTGGGCT 180 CCCCTGAGCT CCTGCCCCAC CCAGGCCCTG CAGCTGGCAG GCTGCTTGAG CCAACTCCAT 240 AGCGGCCTTT TCCTCTACCA GGGGCTCCTG CAGGCCCTGG AAGGGATATC CCCCGAGTTG 300 GGTCCCACCT TGGACACACT GCAGCTGGAC GTCGCCGACT TTGCCACCAC CATCTGGCAG 360 CAGATGGAAG AACTGGGAAT GGCCCCTGCC CTGCAGCCCA CCCAGGGTGC CATGCCGGCC 420 TTCGCCTCTG CTTTCCAGCG CCGGGCAGGA GGGGTCCTCG TTGCTAGCCA TCTGCAGAGC 480 TTCCTGGAGG TGTCGTACCG CGTTCTACGC CACCTTGCGC AGCCCTACGT AGAGGGCGGT 540 GGAGGCTCCC CGGGTGAACC GTCTGGTCCA ATCTCTACTA TCAACCCGTC TCCTCCGTCT 600 AAAGAATCTC ATAAATCTCC AAACATGGCT GATGAAGAAC TGTGTGGTGG GCTGTGGCGG 660 CTGGTCCTGG CACAGCGCTG GATGGAGCGG CTCAAGACTG TCGCTGGGTC CAAGATGCAA 720 GGCTTGCTGG AGCGCGTGAA CACGGAGATA CACrTTGTCA CCAAATGTGC CTTTCAGCCC 780 CCCCCCAGCT GTCTTCGCTT CGTCCAGACC AACATCTCCC GCCTCCTGCA GGAGACCTCC 840 GAGCAGCTGG TGGCGCTGAA GCCCTGGATC ACTCGCCAGA ACTTCTCCCG GTGCCTGGAG 900 CTGCAGTGTC AGCCCGACTC CTCAACCCTG GGCGGTGGGT CAGGAGGTGG GTCAGGOGGT 960 GGTTCTGGCG GAGCATCCGG CGGCGGAAGC GGAGGTGGCT CTGGGGGAGG TAGTGGTACC 1020 CAGGACTGCT CCTTCCAACA CAGCCCCATC TCCTCCGACT TCGCTGTCAA AATCCGTGAG 1080 CTGTCTGACT ACCTGCTTCA AGAmCCCA GTCACCGTGG CCTCCAACCT GCAG 1134 (2)序列編號NO: 254資料； (i)序列特性： (A)長度：1110鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO·. 254 GCTACACCAT TGGGCCCTGC CAGCTCCCTG CCCCAGAGCT TCCTGCTCAA GTCTTTAGAG 60 CAAGTGAGAA AGATCCAGGG CGATGGCGCA GCGCTCCAGG AGAAGCTGTG TGCCACCTAC 120 AAGCTGTGCC ACCCCGAGGA GCTGGTGCTG CTCGGACACT CTCTGGGCAT CCCCTGGGCT 180 CCCCTGAGCT CCTGCCCCAG CCAGGCCCTG CAGCTGGCAG GCTGCTTGAG CCAACTCCAT 240 AGCGGCCITT TCCTCTACCA GGGGCTCCTG CAGGCCCTGG AAGGGATATC cCCCGAGTTG 300 GGTCCCACCT TGGACACACT GCAGCTGGAC GTCGCCGACT TTGCCACCAC CATCTGGCAG 360 CAGATGGAAG AACTGGGAAT GGCCCCTGCC CTGCAGCCCA CCCAGGGTGC CATGCCGGCC 420 TTCGCCTCTG CTITCCAGCG CCGGGCAGGA GGGGTCCTGG TTGCTAGCCA TCTGCAGAGC 480 O:\92\92747.DOC 143- 200413407 TTCCTGGAGG TGTCGTACCG CGTTCTACGC CACCTTGCGC AGCCCTACGT AGAGGGCGGT 540 GGAGGCTCCC CGGGTGAACC GTCTGGTCCA ATCTCTACTA TCAACCCGTC TCCTCCGTCT 600 AAAGAATCTC ATAAATCTCC AAACATGGCT GATGAAGAAC TGTGTGGTGG GCTGTGGCGG 660 CTGGTCCTGG CACAGCGCTG GATGGAGCGG CTCAAGACTG TCGCTGGGTC CAAGATGCAA 720 GGCTTGCTGG AGCGCGTGAA CACGGAGATA CACTTTGTCA CCAAATGTGC CTTTCAGCCC 780 CCCCCCAGCT GTCTTCGCTT CGTCCAGACC AACATCTCCC GCCTCCTGCA GGAGACCTCC 840 GAGCAGCTGG TGGCGCTGAA GCCCTGGATC ACTCGCCAGA ACTTCTCCCG GTGCCTGGAG 900 CTGCAGTGTC AGCCCGACTC CTCAACCCTG CCGCCACCGT GGAGCCCGCG TCCACTCGGC 960 GCCACCGCAC CGACCGCTGG ACAACCGCCT CTGACCCAGG ACTGCTCCTT CCAACACAGC 1020 CCCATCTCCT CCGACTTCGC TGTCAAAATC CGTGAGCTGT CTGACTACCT GCTTCAAGAT 1080 TACCCAGTCA CCGTGGCCTC CAACCTGCAG 1110 (2)序列編號NO: 255資料： (i)序列特性： (A)長度：465鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 255 GCCGATTACC CAGTCACCGT GGCCTCCAAC CTGCAGGACG AGGAGCTCTG CGGGGGCCTC 60 TGGCGGCTGG TCCTGGCACA GCGCTGGATG GAGCGGCTCA AGACTGTCGC TGGGTCCAAG 120 ATGCAAGGCT TGCTGGAGCG CGTGAACACG GAGATACACT TTGTCACCAA ATGTGCCTTr 180 CAGCCCCCCC CCAGCTGTCT TCGCTTCGTC CAGACCAACA TCTCCCGCCT CCTGCAGGAG 240 ACCTCCGAGC AGCTGGTGGC GCTGAAGCCC TGGATCACTC GCCAGAACTT CTCCCGGTGC 300 CTGGAGCTGC AGTGTCAGCC CGACTCCTCA ACCCTGGGCG GTGGGTCAGG AGGTGGGTCA 360 GGAGGTGGAT CCGGAGGTGG CACCCAGGAC TGCTCCTTCC AACACAGCCC CATCTCCTCC 420 GACTTCGCTG TCAAAATCCG TGAGCTGTCT GACTACCTGC TTCAA 465 (2)序列編號NO: 256資料： (i)序列特性： (A)長度：465鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 256 GCCGCCTCCA ACCTGCAGGA CGAGGAGCTC TGCGGGGGCC TCTGGCGGCT GGTCCTGGCA 60 CAGCGCTGGA TGGAGCGGCT CAAGACTGTC GCTGGGTCCA AGATGCAAGG CTTGCTGGAG 120 CGCGTGAACA CGGAGATACA CTTTGTCACC AAATGTGCCT TTCAGCCCCC CCCCAGCTGT 180 CTTCGCITCG TCCAGACCAA CATCTCCCGC CTCCTGCAGG AGACCTCCGA GCAGCTGGTG 240 GCGCTGAAGC CCTGGATCAC TCGCCAGAAC TTCTCCCGGT GCCTGGAGCT GCAGTGTCAG 300

O:\92\92747.DOC -144- 200413407 CCCGACTCCT CAACCCTGGG CGGTGGGTCA GGAGGTGGGT CAGGAGGTGG ATCCGGAGGT 360 GGCACCCAGG ACTGCTCCTT CCAACACAGC CCCATCTCCT CCGACTTCGC TGTCAAAATC 420 CGTGAGCTGT CTGACTACCT GCTTCAAGAT TACCCAGTCA CCGTG 465 (2)序列編號NO: 257資料 • (0序列特性： (A)長度：465鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 257 GCCGTCGCTG GGTCCAAGAT GCAAGGCTTG CTGGAGCGCG TGAACACGGA GATACACTTT 60 GTCACCAAAT GTGCCTTTCA GCCCCCCCCC AGCTGTCTTC GCTTCGTCCA GACCAACATC 120 TCCCGCCTCC TGCAGGAGAC CTCCGAGCAG CTGGTGGCGC TGAAGCCCTG GATCACTCGC 180 CAGAACTTCT CCCGGTGCCT GGAGCTGCAG TGTCAGCCCG ACTCCTCAAC CCTGGGCGGT 240 GGGTCAGGAG GTGGGTCAGG AGGTGGATCC GGAGGTGGCA CCCAGGACTG CTCCTTCCAA 300 CACAGCCCCA TCTCCTCCGA CTTCGCTGTC AAAATCCGTG AGCTGTCTGA CTACCTGCTT 360 CAAGATTACC CAGTCACCGT GGCCTCCAAC CTGCAGGACG AGGAGCTCTG CGGGGGCCTC 420 TGGCGGCTGG TCCTGGCACA GCGCTGGATG GAGCGGCTCA AGACT 465 (2)序列編號NO: 258資料 • (i)序列特性： (A)長度：465鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 258 GCCTCCAAGA TGCAAGGOT GCTGGAGCGC GTGAACACGG AGATACACTT TGTCACCAAA 60 TGTGCCTTTC AGCCCCCCCC CAGCTGTCTT CGCTTCGTCC AGACCAACAT CTCCCGCCTC 120 CTGCAGGAGA CCTCCGAGCA GCTGGTGGCG CTGAAGCCCT GGATCACTCG CCAGAACTTC 180 TCCCGGTGCC TGGAGCTGCA GTGTCAGCCC GACTCCTCAA CCCTGGGCGG TGGGTCAGGA 240 GGTGGGTCAG GAGGTGGATC CGGAGGTGGC ACCCAGGACT GCTCCTTCCA ACACAGCCCC 300 ATCTCCTCCG ACTTCGCTGT CAAAATCCGT GAGCTGTCTG ACTACCTGCT TCAAGAmC 360 CCAGTCACCG TGGCCTCCAA CCTGCAGGAC GAGGAGCTCT GCGGGGGCCT CTGGCGGCTG 420 GTCCTGGCAC AGCGCTGGAT GGAGCGGCTC AAGACTGTCG CTGGG 465

(2)序列編號NO: 259資料： (i)序列特性： O:\92\92747.DOC -145- 200413407 (A) 長度：465鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 259 0 0 0 0 0 0 5 02840626 6'—- ^—-23344

GCCCCCCCCA TCCGAGCAGC GAGCTGCAGT GGTGGATCCG TTCGCTGTCA GCCTCCAACC CGCTGGATGG GTGAACACGG

GCTGTCTTCG TGGTGGCGCT GTCAGCCCGA GAGGTGGCAC AAATCCGTGA TGCAGGACGA AGCGGCTCAA AGATACACTT

CTTCGTCCAG GAAGCCCTGG CTCCTCAACC CCAGGACTGC GCTGTCTGAC GGAGCTCTGC GACTGTCGCT TGTCACCAAA

ACCAACATCT ATCACTCGCC CTGC5GCGGTG TCCTTCCAAC TACCTGCTTC GGGGGCCTCT GGGTCCAAGA TGTGCCTTTC

CCCGCCTCCT AGAACTTCTC GGTCAGGAGG ACAGCCCCAT AAGATTACCC GGCGGCTGGT TGCMGGCTT AGCCC

GCAGGAGACC CCGGTGCCTG TGGGTCAGGA CTCCTCCGAC AGTCACCGTG CCTGGCACAG GCTGGAGCGC (2)序列編號NO·· 260資料： (i)序列特性· (A) 長度：465鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO:

GCCCGCTTCG GCGCTGAAGC CCCGACTCCT GGCACCCAGG CGTGAGCTGT GACGAGGAGC CTCAAGACTG CACTTTGTCA

TCCAGACCAA CCTGGATCAC CAACCCTGGG ACTGCTCCTT CTGACTACCT TCTGCGGGGG TCGCTGGGTC CCAAATGTCC

CATCTCCCGC TCGCCAGAAC CGGTGGGTCA CCAACACAGC GCTTCAAGAT CCTCTGGCGG CAAGATGCAA CTTTCAGCCC

260 CTCCTGCAGG TTCTCCCGGT GGAGGTGGGT CCCATCTCCT TACCCAGTCA CTGGTCCTGG GGCTTGCTGG CCCCCCAGCT

AGACCTCCGA GCCTGGAGCT CAGGAGGTGG CCGACTTCGC CCGTGGCCTC CACAGCGCTG AGCGCGTGAA GTCIT

GCAGCTGGTG GCAGTGTCAG ATCCGGAGGT TGTCAAAATC CAACCTGCAG GATGGAGCGG CACGGAGATA /IV /IV /IV /1% /—\ /V i . 02840626 61123344 (2)序列編號NO·· 261資料： (i)序列特性： (A) 長度：465鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 O:\92\92747.DOC 146 200413407 (xi)序列描述：序列編號NO: 261 GCCACCAACA TCTCCCGCCT CCTGCAGGAG ACCTCCGAGC AGCTGGTGGC GCTGAAGCCC 60 TGGATCACTC GCCAGAACTT CTCCCGGTGC CTGGAGCTGC AGTGTCAGCC CGACTCCTCA 120 ACCCTGGGCG GTGGGTCAGG AGGTGGGTCA GGAGGTGGAT CCGGAGGTGG CACCCAGGAC 180 TGCTCCTTCC AACACAGCCC CATCTCCTCC GACTTCGCTG TCAAAATCCG TGAGCTGTCT 240 GACTACCTGC TTCAAGATTA CCCAGTCACC GTGGCCTCCA ACCTGCAGGA CGAGGAGCTC 300 TGCGGGGGCC TCTGGCGGCT GGTCCTGGCA CAGCGCTGGA TGGAGCGGCT CAAGACTGTC 360 GCTGGGTCCA AGATGCAAGG CTTGCTGGAG CGCGTGAACA CGGAGATACA CTTTGTCACC 420 AAATGTGCCT TTCAGCCCCC CCCCAGCTGT CTTCGCTTCG TCCAG 465 (2)序列編號NO: 262資料： (i)序列特性： (A) 長度：1110鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 262 GCTGATGAAG AACTGTGTGG TGGTCTGTGG CGGCTGGTCC TGGCACAGCG CTGGATGGAG 60 CGGCTCAAGA CTGTCGCTGG GTCCAAGATG CAAGGCTTGC TGGAGCGCGT GAACACGGAG 120 ATACACTTTG TCACCAAATG TGCCTTTCAG CCCCCCCCCA GCTGTCTTCG CTTCGTCCAG 180 ACCAACATCT CCCGCCTCCT GCAGGAGACC TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG 240 ATCACTCGCC AGAACTTCTC CCGGTGCCTG GAGCTGCAGT GTCAGCCCGA CTCCTCAACC 300 CTGGGCGGTG GGTCAGGAGG TGGGTCAGGA GGTGGATCCG GAGGTGGCTC AGGGGGAGGT 360 AGTGGTACCC AGGACTGCTC CTTCCAACAC AGCCCCATCT CCTCCGACTT CGCTGTCAAA 420 ATCCGTGAGC TGTCTGACTA CCTGCTTCAA GATTACCCAG TCACCGTGGC CTCCAACCTG 480 CAGTACGTAG AGGGCGGTGG AGGCTCCCCG GGTGAACCGT CTGGTCCAAT CTCTACTATC 540 AACCCGTCTC CTCCGTCTAA AGAATCTCAT AAATCTCCAA ACATGGCTAC ACmTGGGC 600 CCTGCCAGCT CCCTGCCCCA GAGCTTCCTG CTCAAGTCTT TAGAGCAAGT GAGAAAGATC 660 CAGGGCGATG GCGCAGCGCT CCAGGAGAAG CTGTGTGCCA CCTACAAGCT GTGCCACCCC 720 GAGGAGCTGG TGCTGCTCGG ACACTCTCTG GGCATCCCCT GGGCTCCCCT GAGCTCCTGC 780 CCCAGCCAGG CCCTGCAGCT GGCAGGCTGC TTGAGCCAAC TCCATAGCGG CCmTCCTC 840 TACCAGGGGC TCCTGCAGGC CCTGGAAGGG ATATCCCCCG AGTTGGGTCC CACCTTGGAC 900 ACACTGCAGC TGGACGTCGC CGACTTTGCC ACCACCATCT GGCAGCAGAT GGAAGAACTG 960 GGAATGGCCC CTGCCCTGCA GCCCACCCAG GGTGCCATGC CGGCCTTCGC CTCTGCnTC 1020 CAGCGCCGGG CAGGAGGGGT CCTGGTTGCT AGCCATCTGC AGAGCTTCCT GGAGGTGTCG 1080 TACCGCGTTC TACGCCACCT TGCGCAGCCC 1110 (2)序列編號NO: 263資料： (i)序列特性： (A) 長度：1110鹼基對 (B) 形式：核酸 O:\92\92747.DOC -147- 200413407 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 263 GCAGATGAAG AACTGTGTGG GGGACTGTGG CGTCTGGTCC TGGCACAGCG CTGGATGGAG 60 CGGCTCAAGA CTGTCGCTGG GTCCAAGATG CAAGGCTTGC TGGAGCGCGT GAACACGGAG 120 ATACACTTTG TCACCAAATG TGCCTTTCAG CCCCCCCCCA GCTGTCTTCG CTTCGTCCAG 180 ACCAACATCT CCCGCCTCCT GCAGGAGACC TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG 240 ATCACTCGCC AGAACTTCTC CCGGTGCCTG GAGCTGCAGT GTCAGCCCGA CTCCTCAACC 300 CTGGGCGGTG GGTCAGGAGG TGGGTCAGGA GGTGGATCCG GAGGTGGCTC AGGGGGAGGT 360 AGTGGTACCC AGGACTGCTC CTTCCAACAC AGCCCCATCT CCTCCGACTT TCACCGTGGC CGCTGTCAAA 420 ATCCGTGAGC TGTCTGACTA CCTGCTTCAA GATTACCCAG CTCCAACCTG 480 CAGTACGTAG AGGGCGGTGG AGGCTCCCCG GGTGAACCGT CTGGTCCAAT CTCTACTATC 540 AACCCGTCTC CTCCGTCTAA AGAATCTCAT AAATCTCCAA ACATGGCTAC ACCATTAGGC 600 CCTGCCAGCT CCCTGCCCCA GAGCTTCCTG CTCAAGTGCT TAGAGCAAGT GAGGAAGATC 660 CAGGGCGATG GCGCAGCGCT CCAGGAGAAG CTGTGTGCCA CCTACAAGCT GTGCCACCCC 720 GAGGAGCTGG TGCTGCTCGG ACACTCTCTG GGCATCCCCT GGGCTCCCCT GAGCTCCTGC 780 CCCAGCCAGG CCCTGCAGCT CGCAGGCTGC HGAGCCMC TCCATAGCGG ccmrccTC 840 TACCAGGGGC TCCTGCAGGC CCTGGAAGGG ATATCCCCCG AGWGGGTCC CACCTTGGAC 900 ACACTGCAGC TGGACGTCGC CGACTTTGCC ACCACCATCT GGCAGCAGAT GGAAGAACTG 960 GGAATGGCCC CTGCCCTGCA GCCCACCCAG GGTGCCATGC CGGCCTTCGC CTCTGCnTC 1020 CAGCGCCGGG CAGGAGGGGT CCTGGTTGCT AGCCATCTGC AGAGCTTCCT GGAGGTGTCG 1080 TACCGCGTTC TACGCCACCT TGCGCAGCCC 1110 (2)序列編號NO: 264資料： ⑴序列特性： (A) 長度：1062鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 264 GCTGATGAAG AACTGTGTGG TGGGCTGTGG CGGCTGGTCC TGGCACAGCG CTGGATGGAG 60 CGGCTCAAGA CTGTCGCTGG GTCCAAGATG CAAGGCTTGC TGGAGCGCGT GAACACGGAG 120 ATACACTTTG TCACCAAATG TGCCTTTCAG CCCCCCCCCA GCTGTCTTCG CTTCGTCCAG 180 ACCAACATCT CCCGCCTCCT GCAGGAGACC TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG 240 ATCACTCGCC AGAACTTCTC CCGGTGCCTG GAGCTGCAGT GTCAGCCCGA CTCCTCAACC 300 CTGCCGCCAC CGTGGAGCCC GCGTCCACTC GGCGCCACCG CACCGACCGC TGGACAACCG 360 CCTCTGACCC AGGACTGCTC CTTCCAACAC AGCCCCATCT CCTCCGACTT CGCTGTCAAA 420 ATCCGTGAGC TGTCTGACTA CCTGCTTCAA GATTACCCAG TCACCGTGGC CTCCAACCTG 480 TACGTAGAGG GCGGTGGAGG CTCCCCGGGT GGTCGnCTG GCGGCGGCTC CAACATGGCT 540 ACACCAHGG GCCCTGCCAG CTCCCTGCCC CAGAGCTTCC TGCTCAAGTC TTTAGAGCAA 600 GTGAGGAAGA TCCAGGGCGA TGGCGCAGCG CTCCAGGAGA AGCTGTGTGC CACCTACAAG 660 CTGTGCCACC CCGAGGAGCT GGTGCTGCTC GGACACTCTC TGGGCATCCC CTGGGCTCCC 720 CTGAGCTCCT GCCCCAGCCA GGCCCTGCAG CTGGCAGGCT GCTTGAGCCA ACTCCATAGC 780 GGCCTTITCC TCTACCAGGG GCTCCTGCAG GCCCTGGAAG GGATATCCCC CGAOTTGGGT 840 O:\92\92747.DOC -148 200413407 CCCACCTTGG ACACACTGCA GCTGGACGTC GCCGACTTTG CCACCACCAT CTGGCAGCAG 900 ATGGAAGAAC TGGGAATGGC CCCTGCCCTG CAGCCCACCC AGGGTGCCAT GCCGGCCTTC 960 GCCTCTGCTT TCCAGCGCCG GGCAGGAGGG GTCCTGCTTG CTAGCCATCT GCAGAGCTTC 1020 CTGGAGGTGT CGTACCGCGT TCTACGCCAC CTTGCGCAGC CG 1062 (2)序列編號NO·· 265資料： (i)序列特性： (A)長度：1089鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO__ 265 GCTGATGAAG AACTGTGTGG TGGGCTGTGG CGGCTGGTCC TGGCACAGCG CTGGATGGAG 60 CGGCTCAAGA CTGTCGCTGG GTCCAAGATG CAAGGCTTGC TGGAGCGCGT GAACACGGAG 120 ATACACTTTG TCACCAAATG TGCCTTTCAG CCCCCCCCCA GCTGTCTTCG CTTCGTCCAG 180 ACCAACATCT CCCGCCTCCT GCAGGAGACC TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG 240 ATCACTCGCC AGAACTTCTC CCGGTGCCTG GAGCTGCAGT GTCAGCCCGA CTCCTCAACC 300 CTGGGCGGTG GGTCAGGAGG TGGGTCAGGC GGTGGTTCTG GCGGAGGATC CGGCGGCGGA 360 AGCGGAGGTG GCTCTGGGGG AGGTAGTGGT ACCCAGGACT GCTCCTTCCA ACACAGCCCC 420 ATCTCCTCCG ACTTCGCTGT CAAAATCCGT GAGCTGTCTG ACTACCTGCT TCAAGAmC 480 CCAGTCACCG TGGCCTCCAA CCTGCAGTAC GTAGAGGGCG GTGGAGGCTC CCCGGGTGGT 540 GGTTCTGGCG GCGGCTCCAA CATCGCTACA CCmGGGCC CTGCCAGCTC CCTGCCCCAG 600 AGCTTCCTGC TCAAGTCTTT AGAGCAAGTG AGGAAGATCC AGGGCGATGG CGCAGCGCTC 660 CAGGAGaXGC TGTGTGCCAC CTACAAGCTG TGCCACCCCG AGGAGCTGGT GCTGCTCGGA 720 CACTCTCTGG GCATCCCCTG GGCTCCCCTG AGCTCCTGCC CCAGCCAGGC CCTGCAGCTG 780 GCAGGCTGCT TGAGCCAACT CCATAGCGGC CTTTTCCTCT ACCAGGGGCT CCTGCAGGCC 840 CTGGAAGGGA TATCCCCCGA GTTGGGTCCC ACCTTGGACA CACTGCAGCT GGACGTCGCC 900 GACTITGCCA CCACCATCTG GCAGCAGATG GAAGAACTGG GAATGGCCCC TGCCCTGCAG 960 CCCACCCAGG GTGCCATGCC GGCCTTCGCC TCTGCTTTCC AGCGCCGGGC AGGAGGGGTC 1020 CTGGTTGCTA GCCATCTGCA GAGCTTCCTG GAGGTGTCGT ACCGCGHCT ACGCCACCTT 1080 GCGCAGCCG 1089 (2)序列編號NO: 266資料： (i)序列特性： (A)長度：1044鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 266 GCTGATGAAG AACTGTGTGG TGGGCTGTGG CGGCTGGTCC TGGCACAGCG CTGGATGGAG 60 O:\92\92747.DOC • 149- 200413407 CGGCTCAAGA CTGTCGCTGG GTCCAAGATG CAAGGCTTGC TGGAGCGCGT GAACACGGAG 120 ATACACTTTG TCACCAAATG TGCCTTTCAG CCCCCCCCCA GCTGTCTTCG CTTCGTCCAG 180 ACCAACATCT CCCGCCTCCT GCAGGAGACC TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG 240 ATCACTCGCC AGAACTTCTC CCGGTGCCTG GAGCTGCAGT GTCAGCCCGA CTCCTCAACC 300 CTGCCGCCAC CGTGGAGCCC GCGTCCACTC GGCGCCACCG CACCGACCAC CCAGGACTGC 360 TCCTTCCAAC ACAGCCCCAT CTCCTCCGAC TTCGCTGTCA AAATCCGTGA GCTGTCTGAC 420 TACCTGCTTC AAGATTACCC AGTCACCGTG GCCTCCAACC TGTACGTAGA GGGCGGTGGA 480 GGCTCCCCGG GTGGTGGTTC TGGCGGCGGC TCCAACATGG CTACACCATT GGGCCCTGCC 540 AGCTCCCTGC ccCAGAGCTT CCTGCTCAAG TCTTTAGAGC AAGTGAGRAA GATCCAGGGC 600 GATGGCGCAG CGCTCCAGGA GAAGCTGTGT GCCACCTACA AGCTGTGCCA cccCGAGGAG 660 CTGGTGCTGC TCGGACACTC TCTGGGCATC CCCTGGGCTC CCCTGAGCTC CTGCCCCAGC 720 CAGGCCCTGC AGCTGGCAGG CTGCTTGAGC CAACTCCATA GCGGCCTTTT CCTCTACCAG 780 GGGCTCCTGC AGGCCCTGGA AGGGATATCC CCCGAGTTGG GTCCCACCTT GGACACACTG 840 CAGCTGGACG TCGCCGACTT TGCCACCACC ATCTGGCAGC AGATGGAAGA ACTGGGAATG 900 GCCCCTGCCC TGCAGCCCAC CCAGGGTGCC ATGCCGGCCT TCGCCTCTGC TTTCCAGCGC 960 CGGGCAGGAG GGGTCCTGGT TGCTAGCCAT CTGCAGAGCT TCCTGGAGGT GTCGTACCGC 1020 GTTCTACGCC ACCTTGCGCA GCCG 1044 (2)序列編號NO: 267資料： ⑴序列特性：

(A) 長度：1077鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 267 GCGGATGAGG AGCTGTGCGG TGGCCTCTGG CGGCTGGTCC TGGCACAGCG CTGGATGGAG 60 CGGCTCAAGA CTGTCGCTGG GTCCAAGATG CAAGGCTTGC TGGAGCGCGT GAACACGGAG 120 ATACACTTTG TCACCAAATG TGCCTTTCAG CCCCCCCCCA GCTGTCTTCG CTTCGTCCAG 180 ACCAACATCT CCCGCCTCCT GCAGGAGACC TCCGAGCAGC TGGTGGCGCT GAGGCCCTCG 240 ATCACTCGCC AGAACTTCTC CCGGTGCCTG GAGCTGCAGT GTCAGCCCGA CTCCTCAACC 300 CTGGGCGGTG GGTCAGGAGG TGGATCCGGA GGTACCCAGG ACTGCTCCTT CCAACACAGC 360 CCCATCTCCT CCGACTTCGC TGTCAAAATC CGTGAGCTGT CTGACTACCT GCTTCAAGAT 420 TACCCAGTCA CCGTGGCCTC CAACCTGCAG TACGTAGAGG GCGGTGGAGG CTCCCCGGGT 480 GAACCGTCTG GTCCAATCTC TACTATCAAC CCGTCTCCTC CGTCTAAAGA ATCTCATAAA 540 TCTCCAAACA TGGCTACACC AmGGCCCT GCCAGCTCCC TGCCCCAGAG CTTCCTGCTC 600 AAGTGCTTAG AGCAAGTGAG GAAGATCCAG GGCGATGGCG CAGCGCTCCA GGAGAAGCTG 660 TGTGCCACCT ACAAGCTGTG CCACCCCGAG GAGCTGGTGC TGCTCGGACA CTCTCTGGGC 720 ATCCCCTGGG CTCCCCTGAG CTCCTGCCCC AGCCAGGCCC TGCAGCTGGC AGGCTGCTTG 780 AGCCAACTCC ATAGCGGCCT TTTCCTCTAC CAGGGGCTCC TGCAGGCCCT GGAAGGGATA 840 TCCCCCGAGT TGGGTCCCAC CTTGGACACA CTGCAGCTGG ACGTCGCCGA CTTTGCCACC 900 ACCATCTGGC AGCAGATGGA AGAACTGGGA ATGGCCCCTG CCCTGCAGCC CACCCAGGGT 960 GCCATGCCGG CCTTCGCCTC TGCTITCCAG CGCCGGGCAG GAGGGGTCCT GGTTGCTAGC 1020 CATCTGCAGA GCTTCCTGGA GGTGTCGTAC CGCGTTCTAC GCCACCTTGC GCAGCCC 1077

(2)序列編號NO: 268資料： (i)序列特性： O:\92\92747.DOC -150 200413407 (A) 長度：1092鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO·· 268 GCCGACGAGG AGCTGTGCGG TGGCCTCTGG CGGCTGGTCC TGGCACAGCG CTGGATGGAG 60 CGGCTCAAGA CTGTCGCTGG GTCCAAGATG CAAGGCTTGC TGGAGCGCGT GAACACGGAG 120 ATACACTTTG TCACCAAATG TGCCTTTCAG CCCCCCCCCA GCTGTCTTCG CTTCGTCCAG 180 ACCAACATCT CCCGCCTCCT GCAGGAGACC TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG 240 ATCACTCGCC AGAACTTCTC CCGGTGCCTG GAGCTGCAGT GTCAGCCCGA CTCCTCAACC 300 CTGGGCGGTG GGTCAGGAGG TGGGTCAGGA GGTGGATCCG GAGGTGGCAC CCAGGACTGC 360 TCCTTCCAAC ACAGCCCCAT CTCCTCCGAC TTCGCTGTCA AAATCCGTGA GCTGTCTGAC 420 TACCTGCTTC MGATTACCC AGTCACCGTG GCCTCCAACC TGCAGTACGT AGAGGGCGGT 480 GGAGGCTCCC CGGGTGAACC GTCTGGTCCA ATCTCTACTA TCAACCCGTC TCCTCCGTCT 540 AAAGAATCTC ATAAATCTCC AAACATGGCT ACACCATTAG GCCCTGCCAG CTCCCTGCCC 600 CAGAGCTTCC TGCTCAAGTG CTTAGAGCAA GTGAGGAAGA TCCAGGGCGA TGGCGCAGCG 660 CTCCAGGAGA AGCTGTGTGC CACCTACAAG CTGTGCCACC CCGAGGAGCT GGTGCTGCTC 720 GGACACTCTC TGGGCATCCC CTGGGCTCCC CTGAGCTCCT GCCCCAGCCA GGCCCTGCAG 780 CTGGCAGGCT GCTTGAGCCA ACTCCATAGC GGCCTTTTCC TCTACCAGGG GCTCCTGCAG 840 GCCCTGGAAG GGATATCCCC CGAGnGGGT CCCACCTTGG ACACACTGCA GCTGGACGTC 900 GCCGACTTTG CCACCACCAT CTGGCAGCAG ATGGAAGAAC TGGGAATGGC CCCTGCCCTG 960 CAGCCCACCC AGGGTGCCAT GCCGGCCTTC GCCTCTGCTT TCCAGCGCCG GGCAGGAGGG 1020 GTCCTGGrrG CTAGCCATCT GCAGAGCTTC CTGGAGGTGT CGTACCGCGT TCTACGCCAC 1080 CTTGCGCAGC CC 1092 (2)序列編號NO·· 269資料： ⑴序列特性： (A) 長度：1110鹼基對 (B) 形式：核酸 (C) 股數：單線形列編號NO: 269 (D) 拓撲結構： (xi)序列描述：序 GCAGACGAGG AGCTGTGCGG TGGCCTCTGG CGGCTGGTCC TGGCACAGCG CTGGATGGAG 60 CGGCTCAAGA CTGTCGCTGG GTCCAAGATG CAAGGCTTGC TGGAGCGCGT GAACACGGAG 120 ATACACTTTG TCACCAAATG TGCCTTTCAG CCCCCCCCCA GCTGTCTTCG CTTCGTCCAG 180 ACCAACATCT CCCGCCTCCT GCAGGAGACC TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG 240 ATCACTCGCC AGAACTTCTC CCGGTGCCTG GAGCTGCAGT GTCAGCCCGA CTCCTCAACC 300 CTGGGCGGTG GGTCAGGAGG TGGGTCAGGA .GGTGGATCCG GAGGTGGCTC AGGGGGAGGT 360 AGTGGTACCC AGGACTGCTC CTTCCAACAC AGCCCCATCT CCTCCGACTT CGCTGTCAAA 420 ATCCGTGAGC TGTCTGACTA CCTGCTTCAA GAmCCCAG TCACCGTGGC CTCCAACCTG 480 CAGTACGTAG AGGGCGGTGG AGGCTCCCCG GGTGAACCGT CTGGTCCAAT CTCTACTATC 540 AACCCGTCTC CTCCGTCTAA AGAATCTCAT AAATCTCCAA ACATGGCTAC ACCATTAGGC 600 O:\92\92747.DOC -151- 200413407 CCTGCCAGCT CCCTGCCCCA GAGCTTCCTG CTCAAGTGCT TAGAGCAAGT GAGGAAGATC 660 CAGGGCGATG GCGCAGCGCT CCAGGAGAAG CTGTGTGCCA CCTACAAGCT GTGCCACCCC 720 GAGGAGCTGG TGCTGCTCGG ACACTCTCTG GGCATCCCCT GGGCTCCCCT GAGCTCCTGC 780 CCCAGCCAGG CCCTGCAGCT GGCAGGCTGC TTGAGCCAAC TCCATAGCGG CCTTTTCCTC 840 TACCAGGGGC TCCTGCAGGC CCTGGAAGGG ATATCCCCCG AGnGGGTCC CACCTTGGAC 900 ACACTGCAGC TGGACGTCGC CGACTTTGCC ACCACCATCT GGCAGCAGAT GGAAGAACTG 960 GGAATGGCCC CTGCCCTGCA GCCCACCCAG GGTGCCATGC CGGCCTTCGC CTCTGCTTTC 1020 CAGCGCCGGG CAGGAGGGGT CCTGGTTGCT AGCCATCTGC AGAGCTTCCT GGAGGTGTCG 1080 TACCGCGTTG TACGCCACCT TGCGCAGCCC 1110 (2)序列編號NO: 270資料 ⑴序列特性： (A) 長度：1092鹼基對

(B) 形式：核酸 (C) 股數：單 (D) 拓撲結構·線形 (xi)序列描述：序列編號NO: 270 GCCCCCCCCA GCTGTCITCG CTTCGTCCAG ACCAACATCT CCCGCCTCCT GCAGGAGACC 60 TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG ATCACTCGCC AGAACTTCTC CCGGTGCCTG 120 GAGCTGCAGT GTCAGCCCGA CTCCTCAACC CTGGGCGGTG GGTCAGGAGG TGGGTCAGGA 180 GGTGGATCCG GAGGTGGCAC CCAGGACTGC TCCTTCCAAC ACAGCCCCAT CTCCTCCGAC 240 TTCGCTGTCA AAATCCGTGA GCTGTCTGAC TACCTGCTTC AAGATTACCC AGTCACCGTG 300 GCCTCCAACC TGCAGGACGA GGAGCTCTGC GGGGGCCTCT GGCGGCTGGT CCTGGCACAG 360 CGCTGGATGG AGCGGCTCAA GACTGTCGCT GGGTCCAAGA TGCAAGGCTT GCTGGAGCGC 420 GTGAACACGG AGATACACTT TGTCACCAAA TGTGCCTTTC AGCCGTACGT AGAGGGCGGT 480 GGAGGCTCCC CGGGTGAACC GTCTGGTCCA ATCTCTACTA TCAACCCGTC TCCTCCGTCT 540 AAAGAATCTC ATAAATCTCC AAACATGGCT ACACCAmG GCCCTGCCAG CTCCGTGCCC 600 CAGAGCTTCC TGCTCAAGTG CTTAGAGCAA GTGAGGAAGA TCCAGGGCGA TGGCGCAGCG 660 CTCCAGGAGA AGCTGTGTGC CACCTACAAG CTGTGCCACC CCGAGGAGbo GGTGCTGCTC 720 GGACACTCTC TGGGCATCCC CTGGGCTCCC CTGAGCTCCT GCCCCAGCCA GGCCCTGCAG 780 CTGGCAGGCT GCITGAGCCA ACTCCATAGC GGCCTTITCC TCTACCAGGG GCTCCTGCAG 840 GCCCTGGAAG GGATATCCCC CGAGTTGGGT CCCACCTTGG ACACACTGCA GCTGGACGTC 900 GCCGACITTG CCACCACCAT CTGGCAGCAG ATGGAAGAAC TGGGAATGGC CCCTGCCCTG 960 CAGCCCACCC AGGGTGCCAT GCCGGCCTTC GCCTCTGCTT TCCAGCGCCG GGCAGGAGGG 1020 GTCCTGGTTG CTAGCCATCT GCAGAGCTTC CTGGAGGTGT CGTACCGCGT TATACGCCAC 1080 CTTGCGCAGC CC 1092

(2)序列編號NO: 271資料： (i)序列特性： (A) 長度：1110鹼基對 (B) 形式：核酸 (C) 股數：單 O:\92\92747.DOC -152 200413407 (D)拓撲結構：線形 (xi)序列描述：序列編號NO: 271 GCTTCAAATC TGCAGGATGA AGAGCTGTGC GGGGGCCTCT GGCGGCTGGT CCTGGCACAG 60 CGCTGGATGG AGCGGCTCAA GACTGTCGCT GGGTCCAAGA TGCAAGC5CTT GCTGGAGCGC 120 GTGAACACGG AGATACACTT TGTCACCAAA TGTGCCTTTC AGCCCCCCCC CAGCTGTCTT 180 CGCTTCGTCC AGACCAACAT CTCCCGCCTC CTGCAGGAGA cCTCCGAGCA GCTGGTGGCG 240 CTGAAGCCCT GGATCACTCG CCAGAACTTC TCCCGGTGCC TGGAGCTGCA GTGTCAGCCC 300 GACTCCTCAA CCCTGGGCGG TGGGTCAGGA GGTCGGTCAG GAGGTGGATC CGGAGGTGGC 360 TCAGGGGGAG GTAGTGGTAC CCAGGACTGC TCCTTCCAAC ACAGCCCCAT CTCCTCCGAC 420 TTCGCTGTCA AAATCCGTGA GCTGTCTGAC TACCTGCTTC MGATTACCC ACTCACCGTG 480 GCCTACGTAG AGGC3CGGTGG AGGCTCCCCG GGTGAACCGT CTGGTCCAAT CTCTACTATC 540 AACCCGTCTC ATCCGTCTAA AGAATCTCAT AAATCTCCAA ACATGGCTAC ACCATTAGGC 600 CCTGCCAGCT CCCTGCCCCA GAGCTTCCTG CTCAAGTGCT TAGAGCAAGT GAGGAAGATC 660 CAGGGCGATG GCGCAGCGCT CCAGGAGAAG CTGTGTGCCA CCTACAAGCT GTGCCACCCC 720 GAGGAGCTGG TGCTGCTCGG ACACTCTCTG GGCATCCCCT GGGCTCCCCT GAGCTCCTGC 780 CCCAGCCAGG CCCTGCAGCT GGCAGGCTGC TTGAGCCAAC TCCATAGCGG CCTTITCCTC 840 TACCAGGGGC TCCTGCAGGC CCTGGAAGGG ATATCCCCCG AOTTGGGTCC CACCTTGGAC 900 ACACTGCAGC TGGACGTCGC CGACTTTGCC ACCACCATCT GGCAGCAGAT GGAAGAACTG 960 GGAATGGCCC CTGCCCTGCA GCCCACCCAG GGTGCCATGC CGGCCTTCGC CTCTGCnTC 1020 CAGCGCCGGG CAGGAGGGGT CCTGGTTGCT AGCCATCTGC AGAGCTTCCT GGAGGTGTCG 1080 TACCGCGTTC TACGCCACCT TGCGCAGCCC 1110 (2)序列編號NO: 272資料： (i)序列特性： (A) 長度：1110鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 272 GCTAATCTGC AAGATGAGGA GCTGTGCGGG GGCCTCTGGC GGCTGGTCCT GGCACAGCGC 60 TGGATGGAGC GGCTCAAGAC TGTCGCTGGG TCCAAGATGC AAGGCTTGCT GGAGCGCGTG 120 AACACGGAGA TACACTTTGT CACCAAATGT GCCTITCAGC CCCCCCCCAG CTGTCTTCGC 180 TTCGTCCAGA CCAACATCTC CCGCCTCCTG CAGGAGACCT CCGAGCAGCT GGTGGCGCTG 240 AAGCCCTGGA TCACTCGCCA GAACTTCTCC CGGTGCCTGG AGCTGCAGTG TCAGCCCGAC 300 TCCTCAACCC TGGGCGGTGG GTCAGGAGGT GGGTCAGGAG GTGGATCCGG AGGTGGCTCA 360 GGGGGAGGTA GTGGTACCCA GGACTGCTCC TTCCAACACA GCCCCATCTC CTCCGACTTC 420 GCTGTCAAAA TCCGTGAGCT GTCTGACTAC CTGCTTCAAG ATTACCCAGT CACCGTGGCC 480 TCCTACGTAG AGGGCGGTGG AGGCTCCCCG GGTGAACCGT CTGGTCCAAT CTCTACTATC 540 AACCCGTCTC CTCCGTCTAA AGAATCTCAT AAATCTCCAA ACATGGCTAC ACCATTAGGC 600 CCTGCCAGCT CCCTGCCCCA GAGCTTCCTG CTCAAGTGCT TAGAGCAAGT GAGGAAGATC 660 CAGGGCGATG GCGCAGCGCT CCAGGAGAAG CTGTGTGCCA CCTACAAGCT GTGCCACCCC 720 GAGGAGCTGG TGCTGCTCGG ACACTCTCTG GGCATCCCCT GGGCTCCCCT GAGCTCCTGC 780 CCCAGCCAGG CCCTGCAGCT GGCAGGCTGC TTGAGCCAAC TCCATAGCGG ccmrccTC 840 TACCAGGGGC TCCTGCAGGC CCTGGAAGGG ATATCCCCCG AGTTGGGTCC CACCTTGGAC 900 200413407

ACACTGCAGC GGAATGGCCC CAGCGCCGGG TACCGCGTTA

TGGACGTCGC CTGCCCTGCA CAGGAGGGGT TACGCCACCT CGACTTTGCC GCCCACCCAG CCTGGTTGCT TGCGCAGCCC 273資料

ACCACCATCT GGCAGCAGAT GGAAGAACTG GGTGCCATGC CGGCCTTCGC CTCTGCnTC AGCCATCTGC AGAGCTTCCT GGAGGTGTCG Λυ ΟΑ- οο ^—_ 6 0 0 1 (2)序列編號NO: (i)序列特性： (A) 長度：1110鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 273 GCGCTGCAGG ATGAAGAGCT GTGTGGCGGC CTCTGGCGGC TGGTCCTGGC ACAGCGCTTG ATGGAGCGGC TCAAGACTGT CGCTGGGTCC AAGATGCAAG GCTTGCTGGA GCGCGTGAAC ACGGAGATAC ACTITGTCAC CAAATGTGCC TTTCAGCCCC CCCCCAGCTG TCTTCGCITC GTCCAGACCA ACATCTCCCG CCTCCTGCAG GAGACCTCCG AGCAGCTGGT GGCGCTGAAG CCCTGGATCA CTCGCCAGAA CTTCTCCCGG TGCCTGGAGC TGCAGTGTCA GCCCGACTCC TCAACCCTGG GCGGTGGGTC AGGAGGTGGG TCAGGAGGTG GATCCGGAGG TGGCTCAGGG GGAGGTAGTG GTACCCAGGA CTGCTCCITC CAACACAGCC CCATCTCCTC CGACTTCGCT GTCAAAATCC GTGAGCTGTC TGACTACCTG cnckkGm ACCCAGTCAC CGTGGCCTCC AACTACGTAG AGGGCGGTGG AGGCTCCCCG GGTGAACCGT CTGGTCCAAT CTCTACTATC AACCCGTCTC CTCCGTCTAA AGAATCTCAT AAATCTCCAA ACATGGCTAC ACCATTAGGC CCTGCCAGCT CCCTGCCCCA GAGCTTCCTG CTCAAGTGCT TAGAGCAAGT GAGGAAGATC CAGGGCGATG GCGCAGCGCT CCAGGAGAAG CTGTGTGCCA CCTACAAGCT GTGCCACCCC GAGGAGCTGG TGCTGCTCGG ACACTCTCTG GGCATCCCCT GGGCTCCCCT GAGCTCCTGC CCCAGCCAGG CCCTGCAGCT GGCAGGCTGC TTGAGCCAAC TCCATAGCGG CCTTTTCCTC TACCAGGGGC TCCTGCAGGC CCTGGAAGGG ATATCCCCCG AGTTGGGTCC CACCTTGGAC ACACTGCAGC TGGACGTCGC CGACTTTGCC ACCACCATCT GGCAGCAGAT GGAAGAACTG GGAATGGCCC CTGCCCTGCA GCCCACCCAG GGTGCCATGC CGGCCTTCGC CTCTGCnTC CAGCGCCGGG CAGGAGGGGT CCTGGnGCT AGCCATCTGC AGAGCTTCCT GGAGGTGTCG TACCGCGTTC TACGCCACCT TGCGCAGCCC (2)序列編號NO·. 274資料 • 000000000000000281 0284062840628406001 6 .—- -—-0^3344566770^9911-—_ (i)序列特性： (A) 長度：1110鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 60 (xi)序列描述：序列編號NO·. 274

GCACTGTGCG GTGGTCTGTG GCGTCTGGTC CTGGCACAGC GCTGGATGGA GCGGCTCAAG O:\92\92747.DOC -154- 200413407 ACTGTCGCTG GGTCCAAGAT GCAAGGCTTG CTGGAGCGCG TGAACACGGA GATACACTTT 120 GTCACCAAAT GTGCCTTTCA GCCCCCCCCC AGCTGTCTTC GCTTCGTCCA GACCAACATC 180 TCCCGCCTCC TGCAGGAGAC CTCCGAGCAG CTGGTGGCGC TGAAGCCCTG GATCACTCGC 240 CAGAACTTCT CCCGGTGCCT GGAGCTACAG TGTCAGCCCG ACTCCTCAAC CCTGC5GCGGT 300 GGGTCAGGAG GTGGGTCAGG AGGTGGATCC GGAGGTGGCT CAGGGGGAGG TAGTGGTACC 360 CAGGACTGCT CCTTCCAACA CAGCCCCATC TCCTCCGACT TCGCTGTCAA AATCCGTGAG 420 CTGTCTGACT ACCTGCTTCA AGATTACCCA GTCACCGTGG CCTCCAACCT GCAGGACGAG 480 GAGTACGTAG AGGGCGGTGG AGGCTCCCCG GGTGAACCGT CTGGTCCAAT CTCTACTATC 540 AACCCGTCTC CTCCGTCTAA AGAATCTCAT AAATCTCCAA ACATGGCTAC ACCATTAGGC 600 CCTGCCAGCT CCCTGCCCCA GAGCTTCCTG CTCAAGTGCT TAGAGCAAGT GAGGAAGATC 660 CAGGGCGATG GCGCAGCGCT CCAGGAGAAG CTGTGTGCCA CCTACAAGCT GTGCCACCCC 720 GAGGAGCTGG TGCTGCTCGG ACACTCTCTG GGCATCCCCT GGGCTCCCCT GAGCTCCTGC 780 CCCAGCCAGG CCCTGCAGCT GGCAGGCTGC TTGAGCCAAC TCCATAGCGG ccmrccrc 840 TACCAGGGGC TCCTGCAGGC CCTGGAAGGG ATATCCCCCG AGHGGGTCC CACCTTGGAC 900 ACACTGCAGC TGGACGTCGC CGACTTTGCC ACCACCATCT GGCAGCAGAT GGAAGAACTG 960 GGAATGGCCC CTGCCCTGCA GCCCACCCAG GGTGCCATGC CGGCCTTCGC CTCTGCnTC 1020 CAGCGCCGGG CAGGAGGGGT CCTGCTTGCT AGCCATCTGC AGAGCTTCCT GGAGGTGTCG 1080 TACCGCGTTC TACGCCACCT TGCGCAGCCC 1110 (2)序列編號NO: 275資料： ⑴序列特性： (A) 長度：1092鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 275 GCCTCCAAGA TGCAAGGCTT GCTGGAGCGC GTGAACACGG AGATACACIT TGTCACCAAA 60 TGTGCCTTTC AGCCCCCCCC CAGCTGTCTT CGCTTCGTCC AGACCAACAT CTCCCGCCTC 120 CTGCAGGAGA CCTCCGAGCA GCTGGTGGCG CTGAAGCCCT GGATCACTCG CCAGAACTTC 180 TCCCGGTGCC TGGAGCTGCA GTGTCAGCCC GACTCCTCAA CCCTGGGCGG TGGGTCAGGA 240 GGTGGGTCAG GAGGTGGATC CGGAGGTGGC ACCCAGGACT GCTCCTTCCA ACACAGCCCC 300 ATCTCCTCCG ACTTCGCTGT CAAAATCCGT GAGCTGTCTG ACTACCTGCT TCAAGAmC 360 CCAGTCACCG TGGCCTCCAA CCTGCAGGAC GAGGAGCTCT GCGGGGGCCT CTGGCGGCTG 420 GTCCTGCCAC AGCGCTGGAT GGAGCGGCTC AAGACTGTCG CTGGCTACGT AGAGGGCGGT 480 GGAGGCTCCC CGGGTGAACC GTCTGGTCCA ATCTCTACTA TCAACCCGTC TCCTCCGTCT 540 AAAGAATCTC ATAAATCTCC AAACATGGCT ACACCAmG GCCCTGCCAG CTCCCTGCCC 600 CAGAGCTTCC TGCTCAAGTG CTTAGAGCAA GTGAGGAAGA TCCAGGGCGA TGGCGCAGCG 660 CTCCAGGAGA AGCTGTGTGC CACCTACAAG CTGTGCCACC CCGAGGAGCT GGTGCTGCTC 720 GGACACTCTC TGGGCATCCC CTGGGCTCCC CTGAGCTCCT GCCCCAGCCA GGCCCTGCAG 780 CTGGCAGGCT GCITGAGCCA ACTCCATAGC GGCCTTTTCC TCTACCAGGG GCTCCTGCAG 840 GCCCTGGAAG GGATATCCCC CGAGTTGGGT CCCACOTGG ACACACTGCA GCTGGACGTC 900 GCCGACTTTG CCACCACCAT CTGGCAGCAG ATGGAAGAAC TGGGAATGGC CCCTGCCCTG 960 CAGCCCACCC AGGGTGCCAT GCCGGCCTTC GCCTCTGCTT TCCAGCGCCG GGCAGGAGGG 1020 GTCCTGGTTG CTAGCCATCT GCAGAGCTTC CTGGAGGTGT CGTACCGCGT TCTACGCCAC 1080 CTTGCGCAGC CC 1092 (2)序列編號NO·· 276資料： O:\92\92747.DOC -155- 200413407 ⑴序列特性： (A) 長度：1092鹼基對 (B) 形式：核酸 (C) 股數：單 (D )拓撲結構·線形 (xi)序列描述：序列編號NO: 276 GCCTCCAAGA TGCAAGGCTT GCTGGAGCGC GTGAACACGG AGATACACTT TGTCACCAAA 60 TGTGCCTTTC AGCCCCCCCC CAGCTGTCTT CGCTTCGTCC AGACCAACAT CTCCCGCCTC 120 CTGCAGGAGA CCTCCGAGCA GCTGGTGGCG CTGAAGCCCT GGATCACTCG CCAGAACTTC 180 TCCCGGTGCC TGGAGCTGCA GTGTCAGCCC GACTCCTCAA CCCTGGGCGG TGGGTCAGGA 240 GGTGGGTCAG GAGGTGGATC CGGAGGTGGC ACCCAGGACT GCTCCTTCCA ACACAGCCCC 300 ATCTCCTCCG ACTTCGCTGT CAAAATCCGT GAGCTGTCTG ACTACCTGCT TCAAGAmC 360 CCAGTCACCG TGGCCTCCAA CCTGCAGGAC GAGGAGCTCT GCGGGGGCCT CTGGCGGCTG 420 GTCCTGGCAC AGCGCTGGAT GGAGCGGCTC AAGACTGTCG CTGGCTACGT AGAGGGCGGT 480 GGAGGCTCCC CGGGTGAACC GTCTGGTCCA ATCTCTACTA TCAACCCGTC TCCTCCGTCT 540 AAAGAATCTC ATAAATCTCC AAACATGGCT ACACCAmG GCCCTGCCAG CTCCCTGCCC 600 CAGAGCTTCC TGCTCAAGTG CTTAGAGCAA GTGAGGAAGA TCCAGGGCGA TGGCGCAGCG 660 CTCCAGGAGA AGCTGTGTGC CACCTACAAG CTGTGCCACC CCGAGGAGCT GGTGCTGCTC 720 GGACACTCTC TGGGCATCCC CTGGGCTCCC CTGAGCTCCT GCCCCAGCCA GGCCCTGCAG 780 CTGGCAGGCT GCTTGAGCCA ACTCCATAGC GGCCTTTTCC TCTACCAGGG GCTCCTGCAG 840 GCCCTGGAAG GGATATCCCC CGAGTTGGGT CCCACCTTGG ACACACTGCA GCTGGACGTC 900 GCCGACTTTG CCACCACCAT CTGGCAGCAG ATGGAAGAAC TGGGAATGGC CCCTGCCCTG 960 CAGCCCACCC AGGGTGCCAT GCCGGCCTTC GCCTCTGCTT TCCAGCGCCG GGCAGGAGGG 1020 GTCCTGGTTG CTAGCCATCT GCAGAGCTTC CTGGAGGTGT CGTACCGCGT TCTACGCCAC 1080 CTTGCGCAGC CC 1092 (2)序列編號NO: 277資料： (i)序列特性： (A)長度：1110鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 277 GCGCTGTGTG GTGGTCTGTG GCGTCTGGTC CTGGCACAGC GCTGGATGGA GCGGCTCAAG 60 ACTGTCGCTG GGTCCAAGAT GCAAGGCTTG CTGGAGCGCG TGAACACGGA GATACACTTT 120 GTCACCAAAT GTGCCnTCA GCCCCCCCCC AGCTGTCTTC GCTTCGTCCA GACCAACATC 180 TCCCGCCTCC TGCAGGAGAC CTCCGAGCAG CTGGTGGCGC TGAAGCCCTG GATCACTCGC 240 CAGAACTTCT CCCGGTGCCT GGAGCTGCAG TGTCGGCCCG ACTCCTCAAC CCTGGGCGGT 300 GGGTCAGGAG GTGGGTCAGG AGGTGGATCC GGAGGTGGCT CAGGGGGAGG TAGTGGTACC 360 CAGGACTGCT CCTTCCAACA CAGCCCCATC TCCTCCAACT TCGCTGTCAA GATCCGTGAG 420 CTGTCTGACT ACCTGCTTCA AGATTACCCA GTCACCGTGG CCTCCAACCT GCAGGACGAG 480 O:\92\92747.DOC -156- 200413407 GAGTACGTAG AGGGCGGTGG AGGCTCCCCG GGTGAACCGT CTGGTCCAAT TTTTACTATC 540 AACCCGTCTC CTCCGTCTAA AGAATCTCAT AAATCTCCAA ACATGGCTAC ACCATTAGGC 600 CCTGCCAGCT CCCTGCCCCA GAGCTTCCTG CTCAAGTGCT TAGAGCAAGT GAGGAAGATC 660 CAGGGCGATG GCGCAGCGCT CCAGGAGAAG CTGTGTGCCA CCTACAAGCT GTGCCACCCC 720 GAGGAGCTGG TGCTGCTCGG ACACTCTCTG GGCATCCCCT GGGCTCCCCT GAGCTCCTGC 780 CCCAGCCAGG CCCTGCAGCT GGCAGGCTGC TTGAGCCAAC TCCATAGCGG CCTTTTCCTC 840 TACCAGGGGC TCCTGCAGGC CCTGGAAGGG ATATCCCCCG AGTTGGGTCC CACCTTGGAC 900 ACACTGCAGC TGGACGTCGC CGACTTTGCC ACCACCATCT GGCAGCAGAT GGAAGAACTG 960 GGAATGGCCC CTGCCCTGCA GCCCACCCAG GGTGCCATGC CGGCCTTCGC CTCTGCTTTC 1020 CAGCGCCGGG CAGGAGGGGT CCTGGTTGCT AGCCATCTGC AGAGCTTCCT GGAGGTGTCG 1080 TACCGCGTTC TACGCCACCT TGCGCAGCCC 1110 (2)序列編號NO·· 278資料； (i)序列特性： (A)長度：1110鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 278 GCTGAACTGT GTGGTGGTCT GTGGCGTCTG GTCCTGGCAC AGCGCTGGAT GGAGCGGCTC 60 AAGACTGTCG CTGC5GTCCAA GATGCAAGGC TTGCTGGAGC GCGTGAACAC GGAGATACAC 120 TTTGTCACCA AATGTGCCTT TCAGCCCCCC CCCAGCTGTC TTCGCTTCGT CCAGACCAAC 180 ATCTCCCGCC TCCTGCAGGA GACCTCCGAG CAGCTGGTGG CGCTGAAGCC CTGGATCACT 240 CGCCAGAACT TCTCCCGGTG CCTGGAGCTG CAGTGTCAGC CCGACTCCTC AACCCTGGGC 300 GGTGGGTCAG GAGGTGGGTC AGGAGGTGGA TCCGGAGGTG GCTCAGGGGG AGGTAGTGGT 360 ACCCAGGACT GCTCCTTCCA ACACAGCCCC ATCTCCTCCG ACTTCGCTGT CAAAATCCGT 420 GAGCTGTCTG ACTACCTGCT TCAAGATTAC CCAGTCACCG TGGCCTCCAA CCTGCAGGAC 480 GAGTACGTAG AGGGCGGTGG AGGCTCCCCG GGTGAACCGT CTGGTCCAAT CTCTACTATC 540 AACCCGTCTC CTCCGTCTAA AGAATCTCAT AAATCTCCAA ACATGGCTAC ACCATTAGGC 600 CCTGCCAGCT CCCTGCCCCA GAGCTTCCTG CTCAAGTGCT TAGAGCAAGT GAGGAAGATC 660 CAGGGCGATG GCGCAGCGCT CCAGGAGAAG CTGTGTGCCA CCTACAAGCT GTGCCACCCC 720 GAGGAGCTGG TGCTGCTCGG ACACTCTCTG GGCATCCCCT GGGCTCCCCT GAGCTCCTGC 780 CCCAGCCAGG CCCTGCAGCT GGCAGGCTGC TTGAGCCAAC TCCATAGCGG ccmrccrc 840 TACCAGGGGC TCCTGCAGGC CCTGGAAGGG ATATCCCCCG AGTTGGGTCC CACCTTGGAC 900 ACACTGCAGC TGGACGTCGC CGACTTTGCC ACCACCATCT GGCAGCAGAT GGAAGAACTG 960 GGAATGGCCC CTGCCCTGCA GCCCACCCAG GGTGCCATGC CGGCCTTCGC CTCTGCnTC 1020 CAGCGCCGGG CAGGAGGGGT CCTGGTTGCT AGCCATCTGC AGAGCTTCCT GGAGGTGTCG 1080 TACCGCGTTC TACGCCACCT TGCGCAGCCC 1110 (2)序列編號NO: 279資料： (i)序列特性： (A)長度：1110鹼基對

(B)形式：核酸 O:\92\92747.DOC -157 200413407 (c)股數：單 (D)拓撲結構：線形 (xi)序列描述：序列編號NO·· 279 GCTGAAGAAC TGTGTGGTGG CCTGTGGCGG CTGGTCCTGG CACAGCGCTG GATGGAGCGG 60 CTCAAGACTG TCGCTGGGTC CAAGATGCAA GGCTTGCTGG AGCGCGTGAA CACGGAGATA 120 CACTTTGTCA CCAAATGTGC CTTTCAGCCC CCCCCCAGCT GTCTTCGCTT CGTCCAGACC 180 AACATCTCCC GCCTCCTGCA GGAGACCTCC GAGCAGCTGG TGGCGCTGax GCCCTGGATC 240 ACTCGCCAGA ACTTCTCCCG GTGCCTGGAG CTGCAGTGTC AGCCCGACTC CTCAACCCTG 300 GGCGGTGGGT CAGGAGGTGG GTCAGGAGGT GGATCCGGAG GTGGCTCAGG GGGAGGTAGT 360 GGTACCCAGG ACTGCTCCTT CCAACACAGC CCCATCTCCT CCGACTTCGC TGTCAAAATC 420 CGTGAGCTGT CTGACTACCT GCTTCAAGAT TACCCAGTCA CCGTGGCCTC CAACCTGCAG 480 GACTACGTAG AGGGCGGTGG AGGCTCCCCG GGTGAACCGT CTGGTCCAAT CTCTACTATC 540 AACCCGTCTC CTCCGTCTAA AGAnTCTCAT AAATCTCCAA ACATGGCTAC ACCATTAGGC 600 CCTGCCAGCT CCCTGCCCCA GAGCTTCCTG CTCAAGTGCT TAGAGCAAGT GAGGAAGATC 660 CAGGGCGATG GCGCAGCGCT CCAGGAGAAG CTGTGTGCCA CCTACAAGCT GTGCCACCCC 720 GAGGAGCTGG TGCTGCTCGG ACACTCTCTG GGCATCCCCT GGGCTCCCCT GAGCTCCTGC 780 CCCAGCCAGG CCCTGCAGCT GGCAGGCTGC TTGAGCCAAC TCCATAGCGG CCTTTTCCTC 840 TACCAGGGGC TCCTGCAGGC CCTGGAAGGG ATATCCCCCG AGTTGGGTCC CACCTTGGAC 900 ACACTGCAGC TGGACGTCGC CGACTTTGCC ACCACCATCT GGCAGCAGAT GGAAGAACTG 960 GGAATGGCCC CTGCCCTGCA GCCCACCCAG GGTGCCATGC CGGCCTTCGC CTCTGCnTC 1020 CAGCGCCGGG CAGGAGGGGT CCTGGTTGCT AGCCATCTGC AGAGCTTCCT GGAGGTGTCG 1080 TACCGCGTTC TACGCCACCT TGCGCAGCCC 1110 (2)序列編號NO·. 280資料： (i)序列特性： (A) 長度：1110鹼基對 (B) 形式：核酸 (C) 股數：單 (D )拓撲結構·線形 (xi)序列描述：序列編號NO: 280 GCTCAGGACG AGGAACTGTG TGGTGGTCTC TGGCGGCTGG TCCTGGCACA GCGCTGGATG 60 GAGCGGCTCA AGACTGTCGC TGGGTCCAAG ATGCAAGGCT TGCTGGAGCG CGTGAACACG 120 GAGATACACT TTGTCACCAA ATGTGCCTTT CAGCCCCCCC CCAGCTGTCT TCGCTTCGTC 180 CAGACCAACA TCTCCCGCCT CCTGCAGGAG ACCTCCGAGC AGCTGGTGGC GCTGAAGCCC 240 TGGATCACTC GCCAGAACTT CTCCCGGTGC CTGGAGCTGC AGTGTCAGCC CGACTCCTCA 300 ACCCTGGGCG GTGGGTCAGG AGGTGGGTCA GGAGGTGGAT CCGGAGGTGG CTCAGGGGGA 360 GGTAGTGGTA CCCAGGACTG CTCCTTCCAA CACAGCCCCA TCTCCTCCGA CTTCGCTGTC 420 AAAATCCGTG AGCTGTCTGA CTACCTGCTT CAAGATTACC CAGTCACCGT GGCCTCCAAC 480 CTGTACGTAG AGGGCGGTGG AGGCTCCCCC GGTGAACCGT CTGGTCCAAT CTCTACTATC 540 AACCCGTCTC CTCCGTCTAA AGAATCTCAT AAATCTCCAA ACATGGCTAC ACCATTAGGC 600 CCTGCCAGCT CCCTGCCCCA GAGCTTCCTG CTCAAGTGCT TAGAGCAAGT GAGGAAGATC 660 CAGGGCGATG GCGCAGCGCT CCAGGAGAAG CTGTGTGCCA CCTACAAGCT GTGCCACCCC 720 GAGGAGCTGG TGCTGCTCGG ACACTCTCTG GGCATCCCCT GGGCTCCCCT GAGCTCCTGC 780 200413407 CCCAGCCAGG CCCTGCAGCT GGCAGGCTGC TTGAGCCAAC TCCATAGCGG CCTTTTCCTC 840 TACCAGGGGC TCCTGCAGGC CCTGGAAGGG ATATCCCCCG AGTTGGGTCC CACCTTGGAC 900 ACACTGCAGC TGGACGTCGC CGACTTTGCC ACCACCATCT GGCAGCAGAT GGAAGAACTG 960 GGAATGGCCC CTGCCCTGCA GCCCACCCAG GGTGCCATGC CGGCCTTCGC CTCTGCTTTC 1020 CAGCGCCGGG CAGGAGGGGT CCTGCTTGCT AGCCATCTGC AGAGCTTCCT GGAGGTGTCG 1080 TACCGCGTTC TACGCCACCT TGCGCAGCCC 1110 (2)序列編號NO: 281資料 • (i)序列特性： (A)長度：1092鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 281 GCCACCAACA TCTCCCGCCT CCTGCAGGAG ACCTCCGAGC AGCTGGTGGC GCTGAAGCCC 60 TGGATCACTC GCCAGAACTT CTCCCGGTGC CTGGAGCTGC AGTGTCAGCC CGACTCCTCA 120 ACCCTGGGCG GTGGGTCAGG AGGTGGGTCA GGAGGTGGAT CCGGAGGTGG CACCCAGGAC 180 TGCTCCTTCC AACACAGCCC CATCTCCTCC GACmGCTG TCAAAATCCG TGAGCTGTCT 240 GACTACCTGC TTCMGATTA CCCAGTCACC GTGGCCTCCA ACCTGCAGGA CGAGGAGCTC 300 TGCGGGGGCC TCTGGCGGCT GGTCCTGGCA CAGCGCTGGA TGGAGCGGCT CAAGACTGTC 360 GCTGGGTCCA AGATGCAAGG CTTGCTGGAG CGCGTGAACA CGGAGATACA CTTTGTCACC 420 AAATGTGCCT TTCAGCCCCC CCCCAGCTGT CTTCGCTTCG TCCAGTACGT AGAGGGCGGT 480 GGAGGCTCCC CGGGTGAACC GTCTGGTCCA ATCTCTACTA TCAACCCGTC TCCTCCGTCT 540 AAAGAATCTC ATAAATCTCC AAACATGGCT ACACDOTAG GCCCTGCCAG CTCCCTGCCC 600 CAGAGCTTCC TGCTCAAGTG CTTAGAGCAA GTGAGGAAGA TCCAGGGCGA TGGCGCAGCG 660 CTCCAGGAGA AGCTGTGTGC CACCTACAAG CTGTGCCACC CCGAGGAGCT GGTGCTGCTC 720 GGACACTCTC TGGGCATCCC CTGGGCTCCC CTGAGCTCCT GCCCCAGCCA GGCCCTGCAG 780 CTGGCAGGCT GCTTGAGCCA ACTCCATAGC GGCCTTTTCC TCTACCAGGG GCTCCTGCAG 840 GCCCTGGAAG GGATATCCCC CGAGTTGGGT CCCACCITGG ACACACTGCA GCTGGACGTC 900 GCCGACTITG CCACCACCAT CTGGCAGCAG ATGGAAGAAC TGGGAATGGC CCCTGCCCTG 960 CAGCCCACCC AGGGTGCCAT GCCGGCCTTC GCCTCTGCTT TCCAGCGCCG GGCAGGAGGG 1020 GTCCTGGTTG CTAGCCATCT GCAGAGCTTC CTGGAGGTGT CGTACCGCGT TCTACGCCAC 1080 CTTGCGCAGC CC 1092 (2)序列編號NO: 282資料： (i)序列特性： (A)長度：1065鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形

(xi)序列描述：序列編號NO: 282 O:\92\92747.DOC -159- 200413407 GCTGATGAAG AACTGTGTGG TGGTCTGTGG CGGCTGGTCC TGGCACAGCG CTGGATGGAG 60 CGGCTCAAGA CTGTCGCTGG GTCCAAGATG CAAGGCTTGC TGGAGCGCGT GAACACGGAG 120 ATACACTTTG TCACCAAATG TGCCTTTCAG CCCCCCCCCA GCTGTCTTCG CTTCGTCCAG 180 ACCAACATCT CCCGCCTCCT GCAGGAGACC TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG 240 ATCACTCGCC AGAACTTCTC CCGGTGCCTG GAGCTGCAGT GTCAGCCCGA CTCCTCAACC 300 CTGGGCGGTG GGTCAGGAGG TGGGTCAGGA GGTGGATCCG GAGGTGGCTC AGGGGGAGGT 360 AGTGGTACCC AGGACTGCTC CTTCCAACAC AGCCCCATCT CCTCCGACIT CGCTGTCAAA 420 ATCCGTGAGC TGTCTGACTA CCTGCTTCAA GATTACCCAG TCACCGTGGC CTCCAACCTG 480 CAGTACGTAG AGGGCGGTGG AGGCTCCCCG GGTGGTGGTT CTGGCGGCGG CTCCAACATG 540 GCTACACCAT TGGGCCCTGC CAGCTCCCTG CCCCAGAGCT TCCTGCTCAA GTCTTTAGAG 600 CAAGTGAGAA AGATCCAGGG CGATGGCGCA GCGCTCCAGG AGAAGCTGTG TGCCACCTAC 660 AAGCTGTGCC ACCCCGAGGA GCTGGTGCTG CTCGGACACT CTCTGGGCAT CCCCTGGGCT 720 CCCCTGAGCT CCTGCCCCAG CCAGGCCCTG CAGCTGGCAG GCTGCTTGAG CCAACTCCAT 780 AGCGGCCTTT TCCTCTACCA GGGGCTCCTG CAGGCCCTGG AAGGGATATC CCCCGAGTTG 940 GGTCCCACCT TGGACACACT GCAGCTGGAC GTCGCCGACT TTGCCACCAC CATCTGGCAG 900 CAGATGGAAG AACTGGGAAT GGCCCCTGCC CTGCAGCCCA CCCAGGGTGC CATGCCGGCC 960 TTCGCCTCTG CTTTCCAGCG CCGGGCAGGA GGGGTCCTGG HGCTAGCCA TCTGCAGAGC 1020 TTCCTGGAGG TGTCGTACCG CGTTCTACGC CACCTTGCGC AGCCG 1065 (2)序列編號NO: 283資料：

⑴序列特性： (A)長度：1110鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 283

GCTCAAGATG AAGAACTGTG CGGTGGTCTC TGGCGGCTGG TCCTGGCACA GCGCTGGATG 60 GAGCGGCTCA AGACTGTCGC TGGGTCCAAG ATGCAAGGCT TGCTGGAGCG CGTGAACACG 120 GAGATACACT TTGTCACCAA ATGTGCCTTT CAGCCCCCCC CCAGCTGTCT TCGCTTCGTC 180 CAGACCAACA TCTCCCGCCT CCTGCAGGAG ACCTCCGAGC AGCTGGTGGC GCTGAAGCCC 240 TGGATCACTC GCCAGAACTT CTCCCGGTGC CTGGAGCTGC AGTGTCAGCC CGACTCCTCA 300 ACCCTGGGCG GTGGGTCAGG AGGTGGGTCA GGAGGCGGAT CCGGAGGTGG CTCAGGGGGA 360 GGTAGTGGTA CCCAGGACTG CTCCTTCCAA CACAGCCCCA TCTCCTCCGA CTCCGCTGTC 420 AAAATCCGTG AGCTGTCTGA CTACCTGCTT CAAGATTACC CAGTCACCGT GGCCTCCAAC 480 CTGTACGTAG AGGGCGGTGG AGGCTCCCCG GGTGAACCGT CTGGTCCAAT CTCTACTATC 540 AACCCGTCTC CTCCGTCTAA AGAATCTCAT AAATCTCCAA ACATGGCTAC ACCATTAGGC 600 CCTGCCAGCT CCCTGCCCCA GAGCTTCCTG CTCAAGTGCT TAGAGCAAGT GAGGAAGATC 660 CAGGGCGATG GCGCAGCGCT CCAGGAGAAG CTGTGTGCCA CCTACAAGCT GTGCCACCCC 720 GAGGAGCTGG TGCTGCTCGG ACACTCTCTG GGCATCCCCT GGGCTCCCCT GAGCTCCTGC 780 CCCAGCCAGG CCCTGCAGCT GGCAGGCTGC TTGAGCCAAC TCCATAGCGG CCTTTTCCTC 840 TACCAGGGGC TCCTGCAGGC CCTGGAAGGG ATATCCCCCG AGTTGGGTCC CACCTTGGAC 900 ACACTGCAGC TGGACGTCGC CGACTTTGCC ACCACCATCT GGCAGCAGAT GGAAGAACTG 960 GGAATGGCCC CTGCCCTGCA GCCCACCCAG GGTGCCATGC CGGCCTTCGC CTCTGCTTTC 1020 CAGCGCCGGG CAGGAGGGGT CCTGGTTGCT AGCCATCTGC AGAGCTTCCT GGAGGTGTCG 1080 TACCGCGTTC TACGCCACCT TGCGCAGCCC 1110 O:\92\92747.DOC -160- 200413407 (2)序列編號NO: 284資料： (i)序列特性： (A) 長度：1098鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 284 GCGCTGTGTG GTGGCCTGTG GCGTCTGGTC CTGGCACAGC GCTGGATGGA GCGGCTCAAG 60 ACTGTCGCTG GGTCCAAGAT GCAAGGCTTG CTGGAGCGCG TGAACACGGA GATACACTTT 120 GTCACCAAAT ATGCCTTTCA GCCCCCCCCC AGCTGTCTTC GCTTCGTCCA GACCAACATC 180 TCCCGCCTCC TGCAGGAGAC CTCCGAGCAG CTGGTGGCGC TGAAGCCCTG GATCACTCGC 240 CAGAACTTCT CCCGGTGCCT GGAGCTGCAG TGTCGGCCCG ACTCCTCAAC CCTGGGCGGT 300 GGGTCAGGAG GTGGATCCGG AGGTGGCTCA GGGGGAGGTA GTGGTACCCA GGACTGCTCC 360 TTCCAACACA GCCCCATCTC CTCCGACTTC GCTGTCAAGA TCCGTGAGCT GTCTGACTAC 420 CTGCTTCAAG AmCCCAGT CACCGTGGCC TCCAACCTGC AGGACGAGGA GTACGTAGAG 480 GGCGGTGGAG GCTCCCCGGG TGAACCGTCT GGTCCAATCT CTACTATCAA CCCGTCTCCT 540 CCGTCTAAAG AATCTCATAA ATCTCCAAAC ATGGCTACAC CATTAGGCCC TGCCAGCTCC 600 CTGCCCCAGA GCTTCCTGCT CAAGTGCTTA GAGCAAGTGA GGAAGATCCA GGGCGATGGC 660 GCAGCGCTCC AGGAGAAGCT GTGTGCCACC TACAAGCTGT GCCACCCCGA GGAGCTGGTG 720 CTGCTCGGAC ACTCTCTGGG CATCCCCTGG GCTCCCCTGA GCTCCTGCCC CAGCCAGGCC 780 CTGCAGCTGG CAGGCTGCTT GAGCCAACTC CATAGCGGCC mTCCTCTA CCAGGGGCTC 840 CTGCAGGCCC TGGAAGGGAT ATCCCCCGAG TTGGGTCCCA CCTTGGACAC ACTGCAGCTG 900 GACGTCGCCG ACTTTGCCAC CACCATCTGG CAGCAGATGG AAGAACTGGG AATGGCCCCT 960 GCCCTGCAGC CCACCCAGGG TGCCATGCCG GCCTTCGCCT CTGCnTCCA GCGCCGGGCA 1020 GGAGGGGTCC TGGTTGCTAG CCATCTGCAG AGCITCCTGG AGGTGTCGTA CCGCGTTCTA 1080 CGCCACCTTG CGCAGCCC 1098 (2)序列編號NO·· 285資料： _ (i)序列特性： (A) 長度：1092鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 285 GCCTCCAAGA TGCAAGGCTT GCTGGAGCGC GTGAACACGG AGATACACTT TGTCACCAAA 60 TGTGCCTTTC AGCCCCCCCC CAGCTGTCTT CGCTTCGTCC AGACCAACAT CTCCCGCCTC 120 CTGCAGGAGA CCTCCGAGCA GCTGGTGGCG CTGAAGCCCT GGATCACTCG CCAGAACITC 180 TTCCGGTGCC TGGAGCTGCA GTGTCAGCCC GACTCCTCAA CCCTGGGCGG TGGGTCAGGA 240 GGTGGGTCAG GAGGTGGATC CGGAGGTGGC ACCCAGGACT GCTCCTTCCA ACACAGCCCC 300 ATCTCCTCCG ACTTCGCTGT CAAAATCCGT GAGCTGTCTG ACTACCTGCT TCAAGAmC 360 O:\92\92747.DOC -161 200413407

CCAGTCACCG TGGCCTCCAA CCTGCAGGAC GAGGAGCTCT GCGGGGGCCT CTGGCGGCTG GTCCTGGCAC AGCGCTGGAT GGAGCGGCTC AAGACTGTCG CTGGCTACGT AGAGGGCGGT GGAGGCTCCC CGGGTGAACC GTCTGGTCCA ATCTCTACTA TCAACCCGTC TCCTCCGTCT AAAGAATCTC ATMATCTCC AAACATGGCT ACACCAmG GCCCTGCCAG CTCCCTGCCC CAGAGCTTCC TGCTCAAGTG CTTAGAGCAA GTGAGGAAGA TCCAGGGCGA TGGCGCAGCG CTCCAGGAGA AGCTGTGTGC CACCTACAAG CTGTGCCACC CCGAGGAGCT GGTGCTGCTC GGACACTCTC TCjGGCATCCC CTGGGCTCCC CTGAGCTCCT GCCCCAGCCA GGCCCTGCAG CTGGCAGGCT GCTTGAGCCA ACTCCATAGC GGCcmrcc TCTACCAGGG GCTCCTGCAG GCCCTGGAAG GGATATCCCC CGAGTTGGGT CCCACCTTGG ACACACTGCA GCTGGACGTC GCCGACITTG CCACCACCAT CTGGCAGCAG ATGGAAGAAC TGGGAATGGC CCCTGCCCTG CAGCCCACCC AGGGTGCCAT GCCGGCCTTC GCCTCTGCTT TCCAGCGCCG GGCAGGAGGG GTCCTGaiTG CTAGCCATCT GCAGAGCTTC CTGGAGGTGT CGTACCGCGT TCTACGCCAC CTTGCGCAGC CC 0000000000289 2840628406000 4456677899111 (2)序列編號NO: 286資料： (i)序列特性： (A) 長度：1134鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 286

GCTCAAGACG AAGAACTGTG TGGTGGTCTC TGGCGGCTGG TCCTGGCACA GCGCTGGATG GAGCGGCTCA AGACTGTCGC TGGGTCCAAG ATGCAAGGCT TGCTGGACCG CGTGAACACG GAGATACACT TTGTCACCAA ATGTGCCTTT CAGCCCCCCC CCAGCTGTCT TCGCTTCGTC CAGACCAACA TCTCCCGCpp CCTGCAGGAG ACCTCCGAGC AGCTGGTGGC GCTGAAGCCC TGGATCACTC GCCAGAACTT CTCCCGGTGC CTGGAGCTGC AGTGTCAGCC CGACTCCTCA ACCCTGGGCG GTGGGTCAGG AGGTGGGTCA GGCGGTGGTT CTGGCGGAGG ATCCGGCGGC GGAAGCGGAG GTGGCTCTGG GGGAGGTAGT GGTACCCAGG ACTGCTCCTT CCAACACAGC CCCATCTCCT CCGACTTCGC TGTCAAAATC CGTGAGCTGT CTGACTACCT GCTTCAAGAT TACCCAGTCA CCGTGGCCTC CAACCTGTAC GTAGAGGGCG GTGGAGGCTC CCCGGGTGAA CCGTCTGGTC CAATCTCTAC TATCAACCCG TCTCCTCCGT CTAAAGAATC TCATAAATCT CCAAACATGG CTACACCATT AGGCCCTGCC AGCTCCCTGC CCCAGAGCTT CCTGCTCAAG TGCTTAGAGC AAGTGAGGAA GATCCAGGGC GATGGCGCAG CGCTCCAGGA GAAGCTGTGT GCCACCTACA AGCTGTGCCA CCCCGAGGAG CTGGTGCTGC TCGGACACTC TCTGGGCATC CCCTGGGCTC CCCTGAGCTC CTGCCCCAGC CAGGCCCTGC AGCTGGCAGG CTGCTTGAGC CAACTCCATA GCGGCCTTTT CCTCTACCAG GGGCTCCTGC AGGCCCTGGA AGGGATATCC CCCGAGTTGG GTCCCACCTT GGACACACTG CAGCTGGACG TCGCCGACTT TGCCACCACC ATCTGGCAGC AGATGGAAGA ACTGGGAATG GCCCCTGCCC TGCAGCCCAC CCAGGGTGCC ATGCCGGCCT TCGCCTCTGC TTTCCAGCGC CGGGCAGGAG GGGTCCTGGT TGCTAGCCAT CTGCAGAGCT TCCTGGAGGT GTCGTACCGC GTTCTACGCC ACCTTGCGCA GCCC 60 000000000000000283 284062840628406001 (2)序列編號NO·. 287資料： (i)序列特性： (A)長度：1092鹼基對 O:\92\92747.DOC -162 200413407 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 287 GCCCAAGATG AAGAACTGTG TGGTGGCCTC TGGCGGCTGG TCCTGGCACA GCGCTGGATG 60 GAGCGGCTCA AGACTGTCGC TGGGTCCAAG ATGCAAGGCT TGCTGGAGCG CGTGAACACG 120 GAGATACACT TTGTCACCAA ATGTGCCTTT CAGCCCCCCC CCAGCTGTCT TCGCTTCGTC 180 CAGACCAACA TCTCCCGCCT CCTGCAGGAG ACCTCCGAGC AGCTGGTGGC GCTGAAGCCC 240 TGGATCACTC GCCAGAACTT CTCCCGGTGC CTGGAGCTGC AGTGTCAGCC CGACTCCTCA 300 ACCCTGCCGC CACCGTGGAG CCCGCGTCCA CTCGGCGCCA CCGCACCGAC CACCCAGGAC 360 TGCTCCTTCC AACACAGCCC CATCTCCTCC GACTTCGCTG TCAAAATCCG TGAGCTGTCT 420 GACTACCTGC TTCAAGATTA CCCAGTCACC GTGGCCTCCA ACCTGTACGT AGAGGGCGGT 480 GGAGGCTCCC CGGGTGAACC GTCTGGTCCA ATCTCTACTA TCAACCCGTC TCCTCCGTCT 540 AAAGAATCTC ATAAATCTCC AAACATGGCT ACACCAmG GCCCTGCCAG CTCCCTGCCC 600 CAGAGCTTCC TGCTCAAGTG CTTAGAGCAA GTGAGGAAGA TCCAGGGCGA TGGCGCAGCG 660 CTCCAGGAGA AGCTGTGTGC CACCTACAAG CTGTGCCACC CCGAGGAGCT GGTGCTGCTC 720 GGACACTCTC TGGGCATCCC CTGGGCTCCC CTGAGCTCCT GCCCCAGCCA GGCCCTGCAG 780 CTGGCAGGCT GCTTGAGCCA ACTCCATAGC GGCCTTTTCC TCTACCAGGG GCTCCTGCAG 840 GCCCTGGAAG GGATATCCCC CGAGTTGGGT CCCACCITGG ACACACTGCA GCTGGACGTC 900 GCCGACTTTG CCACCACCAT CTGGCAGCAG ATGGAAGAAC TGGGAATGGC CCCTGCCCTG 960 CAGCCCACCC AGGGTGCCAT GCCGGCCTTC GCCTCTGCTT TCCAGCGCCG GGCAGGAGGG 1020 GTCCTGGTTG CTAGCCATCT GCAGAGCTTC CTGGAGGTGT CGTACCGCGT TCTACGCCAC 1080 CTTGCGCAGC CC 1092 (2)序列編號NO: 288資料： (i)序列特性： (A) 長度：1110鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 288 GCCCAAGATG AAGAACTGTG TGGTGGCCTC TGGCGGCTGG TCCTGGCACA GCGCTGGATG 60 GAGCGGCTCA AGACTGTCGC TGGGTCCAAG ATGCAAGGCT TGCTGGAGCG CGTGAACACG 120 GAGATACACT TTGTCACCAA ATGTGCCTTT CAGCCCCCCC CCAGCTGTCT TCGCTTCGTC 180 CAGACCAACA TCTCCCGCCT CCTGCAGGAG ACCTCCGAGC AGCTGGTGGC GCTGAAGCCC 240 TGGATCACTC GCCAGAACTT CTCCCGGTGC CTGGAGCTGC AGTGTCAGCC CGACTCCTCA 300 ACCCTGCCGC CACCGTGGAG CCCGCGTCCA CTCGGCGCCA CCGCACCGAC CGCTGGACAA 360 CCGCCTCTGA CCCAGGACTG CTCCTTCCAA CACAGCCCCA TCTCCTCCGA CTTCGCTGTC 420 AAAATCCGTG AGCTGTCTGA CTACCTGCTT CAAGATTACC CAGTCACCGT GGCCTCCAAC 480 CTGTACGTAG AGGGCGGTGG AGGCTCCCCG GGTGAACCGT CTGGTCCAAT CTCTACTATC 540 AACCCGTCTC CTCCGTCTAA AGAATCTCAT AAATCTCCAA ACATGGCTAC ACCATTAGGC 600 CCTGCCAGCT CCCTGCCCCA GAGCTTCCTG CTCAAGTGCT TAGAGCAAGT GAGGAAGATC 660 O:\92\92747.DOC • 163- 200413407 CAGGGCGATG GCGCAGCGCT CCAGGAGAAG CTGTGTGCCA CCTACAAGCT GTGCCACCCC 720 GAGGAGCTGG TGCTGCTCGG ACACTCTCTG GGCATCCCCT GGGCTCCCCT GAGCTCCTGC 780 CCCAGCCAGG CCCTGCAGCT GGCAGGCTGC TTGAGCCAAC TCCATAGCGG CCTTTTCCTC 840 TACCAGGGGC TCCTGCAGGC CCTGGAAGGG ATATCCCCCG AGHGGGTCC CACCTTGGAC 900 ACACTGCAGC TGGACGTCGC CGACTTTGCC ACCACCATCT GGCAGCAGAT GGAAGAACTG 960 GGAATGGCCC CTGCCCTGCA GCCCACCCAG GGTGCCATGC CGGCCTTCGC CTCTGCTTTC 1020 CAGCGCCGGG CAGGAGGGGT CCTGGTTGCT AGCCATCTGC AGAGCTTCCT GGAGGTGTCG 1080 TACCGCGTTC TACGCCACCT TGCGCAGCCC 1110 (2)序列編號NO: 289資料： (i)序列特性： (A)長度：1134鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 289 GCTGATGAAG AACTGTGTGG TGGGCTGTGG CGGCTGGTCC TGGCACAGCG CTGGATGGAG 60 CGGCTCAAGA CTGTCGCTGG GTCCAAGATG CAAGGCTTGC TGGAGCGCGT GAACACGGAG 120 ATACACTTTG TCACCAAATG TGCCTTTCAG CCCCCCCCCA GCTGTCTTCG CTTCGTCCAG 180 ACCAACATCT CCCGCCTCCT GCAGGAGACC TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG 240 ATCACTCGCC AGAACTTCTC CCGGTGCCTG GAGCTGCAGT GTCAGCCCGA CTCCTCAACC 300 CTGGGCGGTG GGTCAGGAGG TGGGTCAGGC GGTGGTTCTG GCGGAGGATC CGGCGGCGGA 360 AGCGGAGGTG GCTCTGGCjGG AGGTAGTGGT ACCCAGGACT GCTCCTTCCA ACACAGCCCC 420 ATCTCCTCCG ACTTCGCTGT CAAAATCCGT GAGCTGTCTG ACTACCTGCT TCMGATTAC 480 CCAGTCACCG TGGCCTCCAA CCTGCAGTAC GTAGAGGGCG GTGGAGGCTC CCCGGGTGAA 540 CCGTCTGGTC CAATCTCTAC TATCAACCCG TCTCCTCCGT CTAAAGAATC TCATAAATCT 600 CCAAACATGG CTACACCATT AGGCCCTGCC AGCTCCCTGC CCCAGAGCTT CCTGCTCAAG 660 TGCTTAGAGC AAGTGAGGAA GATCCAGGGC GATGGCGCAG CGCTCCAGGA GAAGCTGTGT 720 GCCACCTACA AGCTGTGCCA CCCCGAGGAG CTGGTGCTGC TCGGACACTC TCTGGGCATC 780 CCCTGGGCTC CCCTGAGCTC CTGCCCCAGC CAGGCCCTGC AGCTGGCAGG CTGCTTGAGC 840 CAACTCCATA GCGGCCmr CCTCTACCAG GGGCTCCTGC AGGCCCTGGA AGGGATATCC 900 CCCGAGTTGG GTCCCACCTT GGACACACTG CAGCTGGACG TCGCCGACIT TGCCACCACC 960 ATCTGGCAGC AGATGGAAGA ACTGGGAATG GCCCCTGCCC TGCAGCCCAC CCAGGGTGCC 1020 ATGCCGGCCT TCGCCTCTGC TTTCCAGCGC CGGGCAGGAG GGGTCCTGGT TGCTAGCCAT 1080 CTGCAGAGCT TCCTGGAGGT GTCGTACCGC GTTCTACGCC ACCTTGCGCA GCCC 1134 (2)序列編號NO: 290資料： ⑴序列特性： (A) 長度：1134鹼基對(B) 形式：核酸 (D)拓撲結構：線形 O:\92\92747.DOC 164 200413407 (xi)序列描述：序列編號NO·· 290

GCTGATGAAG AACTGTGTGG TGGGCTGTGG CGGCTGGTCC TGGCACAGCG CTGGATGGAG CGGCCCAAGA CTGTCGCTGG GTCCAAGATG CAAGGCTTGC TGGAGCGCGT GAACACGGAG ATACACTTTG TCACCAAATG TGCCTTTCAG CCCCCCCCCA GCTGTCTTCG CTTCGTCCAG ACCAACATCT CCCGCCTCCT GCAGGAGACC TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG ATCACTCGCC AGAACTTCTC CCGGTGCCTG GAGCTGCAGT GTCAGCCCGA CTCCTCAACC CTGC5GCGGTG GGTCAGGAGG TGGGTCAGGC GGTGGnCTG GCGGAGGATC CGGCGGCGGA AGCGGAGGTG GCTCTGGGGG AGGTAGTGGT ACCCAGGACT GCTCCTTCCA ACACAGCCCC ATCTCCTCCG ACTTCGCTGT CAAAATCCGT GAGCTGTCTG ACTACCTGCT TCAAGAmC CCAGTCACCG TGGCCTCCAA CCTGCAGTAC GTAGAGGGCG GTGGAGGCTC CCCGGGTGAA CCGTCTGGTC CAATCTCTAC TATCAACCCG TCTCCTCCGT CTAAAGAATC TCATAAATCT CCAAACATGG CTACACCATT AGGCCCTGCC AGCTCCCTGC CCCAGAGCTT CCTGCTCAAG TGCTTAGAGC AAGTGAGGAA GATCCAGGGC GATGGCGCAG CGCTCCAGGA GAAGCTGTGT GCCACCTACA AGCTGTGCCA CCCCGAGGAG CTGGTGCTGC TCGGACACTC TCTGGGCATC CCCTGGGCTC cCCTGAGCTC CTGCCCCAGC CAGGCCCTGC AGCTGGCAGG CTGCTTGAGC CAACTCCATA GCGGCCTTIT CCTCTACCAG GGGCTCCTGC AGGCCCTGGA AGGGATATCC CCCGAGTTGG GTCCCACCTT GGACACACTG CAGCTGGACG TCGCCGACTT TGCCACCACC ATCTGGCAGC AGATGGAAGA ACTGGGAATG GCCCCTGCCC TGCAGCCCAC CCAGGGTGCC ATGCCGGCCT TCGCCTCTGC TTTCCAGCGC CGGGCAGGAG GGGTCCTGGT TGCTAGCCAT CTGCAGAGCT TCCTGGAGGT GTCGTACCGC GTTCTACGCC ACCTTGCGCA GCCC 0 0 4 000000000000000283 0 2 8 4 0 6 284062840600-—-6 11 1—- 2 3 3 4 4 5 6 6 7 7 8 9 9 11 ι—ι ι—ι (2)序列編號NO: 291資料： (i)序列特性： (A) 長度：1110鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 291

GCGGACGAGG AGCTGTGCGG TGGCCTCTGG CGGCTGGTCC TGGCACAGCG CTGGATGGAG CGGCTCAAGA CTGTCGCTGG GTCCAAGATG CAAGGCTTGC TGGAGCGCGT GAACACGGAG ATACACTTTG TCACCAAATG TGCCTTTCAG CCCCCCCCCA GCTGTCTTCG CTTCGTCCAG ACCAACATCT CCCGCCTCCT GCAGGAGACC TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG ATCACTCGCC AGAACTTCTC CCGGTGCCTG GAGCTGCAGT GTCAGCCCGA CTCCTCAACC CTGCCGCCAC CGTGGAGCCC GCGTCCACTC GGCGCCACCG CACCGACCGC TGGACAACCG CCTCTGACCC AGGACTGCTC CTTCCAACAC AGCCCCATCT CCTCCGACTT CGCTGTCAAA ATCCGTGAGC TGTCTGACTA CCTGCTTCAA GATTACCCAG TCACCGTGGC CTCCAACCTG CAGTACGTAG AGGGCGGTGG AGGCACCCCG GGTGAACCGT CTGGTCCAAT CTCTACTATC AACCCGTCTC CTCCGTCTAA AGAATCTCAT AAATCTCCAA ACATGGCTAC ACCAmGGC CCTGCCAGCT CCCTGCCCCA GAGCTTCCTG CTCAAGTGCT TAGAGCAAGT GAGGAAGATC CAGGGCGATG GCGCAGCGCT CCAGGAGAAG CTGTGTGCCA CCTACAAGCT GTGCCACCCC GAGGAGCTGG TGCTGCTCGG ACACTCTCTG GGCATCCCCT GGGCTCCCCT GAGCTCCTGC CCCAGCCAGG CCCTGCAGCT GGCAGGCTGC HGAGCCAAC TCCATAGCGG ccmrccTC TACCAGGGGC TCCTGCAGGC CCTGGAAGGG ATATCCCCCG AGTTGGGTCC CACCTTGGAC ACACTGCAGC TGGACGTCGC CGACTTTGCC ACCACCATCT GGCAGCAGAT GGAAGAACTG GGAATGGCCC CTGCCCTGCA GCCCACCCAG GGTGCCATGC CGGCCTTCGC CTCTGCTTTC o 0000000000000002 02840628406284060 61123344566778991 O:\92\92747.DOC -165- 200413407 CAGCGCCGGG CAGGAGGGGT CCTGGTTGCT AGCCATCTGC AGAGCTTCCT GGAGGTGTCG 1080 TACCGCGTTC TACGCCACCT TGCGCAGCCC 1110 (2)序列編號NO: 292資料 • (i)序列特性： (A)長度：1043鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 292 GCTGATGAGG AGCTGTGTGG TGGTCTGTGG CGGCTGGTCC TGGCACAGCG CTGGATGGAG 60 CGGCTCAAGA CTGTCGCTGG GTCCAAGATG CAAGGCITGC TGGAGCGCGT GAACACGGAG 120 ATACACTTTG TCACCAAATG TGCCITTCAG CCCCCCCCCA GCTGTCTTCG CTTCGTCCAG 180 ACCAACATCT CCCGCCTCCT GCAGGAGACC TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG 240 ATCACTCGCC AGAACTTCTC CCGGTGCCTG GAGCTGCAGT GTCAGCCCGT AGAGACGGTG 300 TTTCACCGTG TCAGCCAGGA TGGTCTAGAT CTCCTGACCT CGACCCAGGA CTGCTCCTTC 360 CAACACAGCC CCATCTCCTC CGACTTCGCT GTCAAAATCC GTGAGCTGTC TGACTACCTG 420 CTTCAAGATT ACCCAGTCAC CGTGGCCTCC AACCTGCAGT ACGTAGAGGG CGGTGGAGGC 480 TCCCCGGGTG GTGGTTCTGG CGGCGGCTCC AACATGGCTA CAtmTGGG CCCTGCCAGC 540 TCCCTGCCCC AGAGCTTCCT GCTCAAGTCT mGAGCAAG TGAGAAAGAT CCACGGCGAT 600 GGCGCAGCGC TCCAGGAGAA GCTGTGTGCC ACTAACAAGC TGTGCCACCC CGAGGAGCTG 660 GTGCTGCTCG GACACTCTCT GGGCATCCCC TGGGCTCCCC TGAGCTCCTG CCCCAGCCAG 720 GCCCTGCAGC TGGCAGGCTG CTTGAGCCAA CTCCATAGCG GCCTTTTCCT CTACCAGGGG 780 CTCCTGCAGG CCCTGGAAGG GATATCCCCC GAGTTGGGTC CCACCTTGGA CACACTGCAG 840 CTGGACGTCG CCGACTTTGC CACCACCATC TGGCAGCAGA TGGAAGAACT GGGAATGGCC 900 CCTGCCCTGC AGCCCACCCA GGGTGCCATG CCGGCCTTCG CCTCTGCTTT CCAGCGCCGG 960 GCAGGAGGGC TCCTGGTTGC TAGCCATCTG CAGAGCTTCC TGGAGGTGTC GTACCGCGTT 1020 CTACGCCACC HGCGCAGCC G 1041 (2)序列編號NO: 293資料： (i)序列特性： (A)長度：1152鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 293 GCTGATGAAG AACTGTGTGG TGGGCTGTGG CGGCTGGTCC TGGCACAGCG CTGGATGGAG 60 CGGCTCAAGA CTGTCGCTGG GTCCAAGATG CAAGGCTTGC TGGAGCGCGT GAACACGGAG 120 ATACACTITG TCACCAAATG TGCCTTTCAG CCCCCCCCCA GCTGTCTTCG CTTCGTCCAG 180 ACCAACATCT CCCGCCTCCT GCAGGAGACC TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG 240 O:\92\92747.DOC -166- 200413407 ATCACTCGCC AGAACTTCTC CCGGTGCCTG GAGCTGCAGT GTCAGCCCGA CTCCTCAACC 300 CTGTACGTAG AGGGCGGTGG AGGCTCCCCG GGTGAACCGT CTGGTCCAAT CTCTACTATC 360 AACCCGTCTC CTCCGTCTAA AGAATCTCAT AAATCTCCAA ACATGGCTAC ACCATTGGGC 420 CCTGCCAGCT CCCTGCCCCA GAGCTTCCTG CTCAAGTCTT TAGAGCAAGT GAGAAAGATC 480 CAGGGCGATG GCGCAGCGCT CCAGGAGAAG CTGTGTGCCA CCTACAAGCT GTGCCACCCC 540 GAGGAGCTGG TGCTGCTCGG ACACTCTCTG GGCATCCCCT GGGCTCCCCT GAGCTCCTGC 600 CCCAGCCAGG CCCTGCAGCT GGCAGGCTGC HGAGCCAAC TCCATAGCGG ccmTccrc 660 TACCAGGGGC TCCTGCAGGC CCTGGAAGGG ATATCCCCCG AGTTGGGTCC CACCTTGGAC 720 ACACTGCAGC TGGACGTCGC CGACTTTGCC ACCACCATCT GGCAGCAGAT GGAAGAACTG 780 GGAATGGCCC CTGCCCTGCA GCCCACCCAG GGTGCCATGC CGGCCTTCGC CTCTGCTTTC 840 CAGCGCCGGG CAGGAGGC5GT CCTGGTTGCT AGCCATCTGC AGAGCTTCCT GGAGGTGTCG 900 TACCGCGTTC TACGCCACCT TGCGCAGCCC TACGTAGAGG GCGGTGGAGG CTCCCCGGGT 960 GAACCGTCTG GTCCAATCTC TACTATCAAC CCGTCTCCTC CGTCTAAAGA ATCTCATAAA 1020 TCTCCAAACA TGGCAACCCA GGACTGCTCT TTTCAACACA GCCCCATCTC CTCCGACTTC 1080 GCTGTCAAAA TCCGTGAGCT GTCTGACTAC CTGCTTCAAG ATTACCCAGT CACCGTGGCC 1140 TCCAACCTGC AG 1152 (2)序列編號NO: 294資料：鲁 (i)序列特性： (A) 長度：1047鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 294 GCCACCCAGG ACTGCTCCTT TCAACACAGC CCCATCTCCT CCGACTTCGC TGTCAAAATC 60 CGTGAGCTGT CTGACTACCT GCTTCAAGAT TACCCAGTCA CCGTGGCCTC CAACCTGCAG 120 GAGCCGAAGA GCCCGGACAC CCATACTAGT CCGCCATCTC CGACACCATT AGGCCCTGCC 180 AGCTCCCTGC CCCAGAGCTT CCTGCTCAAG TCTTTAGAGC AAGTGAGAAA GATCCAGGGC 240 GATGGCGCAG CGCTCCAGGA GAAGCTGTGT GCCACCTACA AGCTGTGCCA CCCCGAGGAG 300 CTGGTGCTGC TCGGACACTC TCTGGGCATC CCCTGGGCTC CCCTGAGCTC CTGCCCCAGC 360 CAGGCCCTGC AGCTGGCAGG CTGCTTGAGC CAACTCCATA GCGGCCTTTT CCTCTACCAG 420 GGGCTCCTGC AGGCCCTGGA AGGGATATCC CCCGAffTTGG GCCCCACCTT GGACACACTG 480 CAGCTGGACG TCGCCGACTT TGCCACCACC ATCTGGCAGC AGATGGAAGA ACTGGGAATG 540 GCCCCTGCCC TGCAGCCCAC CCAGGGTGCC ATGCCGGCCT TCGCCTCTGC TITCCAGCGC 600 CGGGCAGGAG GGGTCCTGGT TGCTAGCCAT CTGCAGAGCT TCCTGGAGGT GTCGTACCGC 660 GTTCTACGCC ACCTTGCGCA GCCCTCTGCA GAACCGAAAT CTCCGGATAC TCATACCAGC 720 CCGCCATCCC CGGCTTCTM TCTGCAAGAT GAAGAGCTGT GCGGGGGCCT CTGGCGGCTG 780 GTCCTGGCAC AGCGCTGGAT GGAGCGGCTC AAGACTGTCG CTGGGTCCAA GATGCAAGGC 840 TTGCTGGAGC GCGTGAACAC GGAGATACAC TTTGTCACCA AATGTGCCTT TCAGCCCCCC 900 CCCAGCTGCC TTCGCTTCGT CCAGACCAAC ATCTCCCGCC TCCTGCAGGA GACCTCCGAG 960 CAGCTGGTGG CGCTGAAGCC CTGGATCACT CGCCAGAACT TCTCCCGGTG CCTGGAGCTG 1020 CAGTGTCAGC CCGACTCCTC AACCCTG 1047

(2)序列編號NO: 295資料： (i)序列特性： O:\92\92747.DOC -167- 200413407 (A) 長度：1043鹼基對 (B) 形式：核酸 (C) 股數：單 (D)拓撲結構：線形 (xi)序列描述：序列編號NO: 295 GCCACCCAGG ACTGCTCCTT TCAACACAGC CCCATCTCCT CCGACTTCGC TGTCAAAATC 60 CGTGAGCTGT CTGACTACCT GCTTCAAGAT TACCCAGTCA CCGTGGCCTC CAACCTGCAG 120 GACGAGGAGC TCTGCGGGGG CCTCTGGCGG CTGGTCCTGG CACAGCGCTG GATGGAGCGG 180 CTCAAGACTG TCGCTGGGTC CAAGATGCAA GGCTGGCAGG GGCGCGTGAA CACGGAGATA 240 CACTTTGTCA CCAAATGTGC CTTTCCGAAG AGCCCGGACA CCCATACTAG TCCGCCATCT 300 cCGGGTACAC CATTGGGCCC TGCCAGCTCC CTGCCCCAGA GCTTCCTGCT CAAGTCTTTA 360 GAGCAAGTGA GAAAGATCCA GGGCGATGGC GCAGCGCTCC AGGAGAAGCT GTGTGCCACT 420 ACAAGCTGTG CCACCCCGAG GAGCTGGTGC TGCTCGGACA CTCTCTGGGC ATCCCCTGGG 480 CTCCCCTGAG CTCCTGCCCC AGCCAGGCCC TGCAGCTGGC AGGCTGCTTG AGCCAACTCC 540 ATAGCGGCCT TTTCCTCTAC CAGGGGCTCC TGCAGGCCCT GGAAGGGATA TCCCCCGAGT 600 TGGGTCCCAC CTTGGACACA CTGCAGCTGG ACGTCGCCGA CTTTGCCACC ACCATCTGGC 660 AGCAGATGGA AGAACTGGGA ATGGCCCCTG CCCTGCAGCC CACCCAGGGT GCCATGCCGG 720 CCTTCGCCTC TGCTTTCCAG CGCCGGGCAG GAGGGGTCCT GGTTGCTAGC CATCTGCAGA 780 GCTTCCTGGA GGTGTCGTAC CGCGTTCTAC GCCACCTTGC GCAGCCCTCT GCAGAACCGA 840 AATCTCCGGA TACTCATACC AGCCCGCCAT CCCCGGGTAA GGCCTTTCAG CCCCCCCCCA 900 GCTGTCTTCG CTTCGTCCAG ACCAACATCT CCCGCCTCCT GCAGGAGACC TCCGAGCAGC 960 TGGTGGCGCT GAAGCCCTGG ATCACTCGCC AGAACTTCTC CCGGTGCCTG GAGCTGCAGT 102C GTCAGCCCGA CTCCTCAACC CTG 1043 (2)序列編號NO: 296資料： (i)序列特性： (A)長度：1065鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 296 GCTGATGAAG AACTGTGTGG TGGTCTGTGG CGGCTGGTCC TGGCACAGCG CTGGATGGAG 60 CGGCTCAAGA CTGTCGCTGG GTCCAAGATG CAAGGCTTGC TGGAGCGCGT GAACACGCAG 120 ATACACTTTG TCACCAAATC TGCCITTCAG CCCCCCCCCA GCTGTCTTCC CTTCGTCCAG 180 ACCAACATCT CCCGC00CCT GCAGGAGACC TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG 240 ATCACTCGCC AGAACTTCTC CCGGTGCCTG GAGCTGCAGT GTCAGCCCGA CTCCTCAACC 300 CTGC3GCGGTG GGTCAGGAGG TGGGTCAGGA GGTGGATCCG GAGGTGGCTC AGGGGGAGGT 360 AGTGGTACCC AGGACTCCTC CTTCCAACAC AGCCCCATCT CCTCCGACTT CGCTGTCAAA 420 ATCCGTGAGC TGTCTGACTA CCTGCTTCAA GATTACCCAG TCACCGTGGC CTCCAACCTG 480 CAGTACGTAG AGGGCGGTGG AGGCTCCCCG GGTGGTGGTT CTGGCGGCGG CTCCAACATG 540 GCTACACCAT TGGGCCCTGC CAGCTCCCTG CCCCAGAGCT TCCTGCTCAA GTCTTTAGAG 600 CAAGTGAGAA AGATCCAGGG CGATGGCGCA GCGCTCCAGG AGAAGCTGTG TGCCACTAAC 660

O:\92\92747.DOC -168 200413407 AAGCTGTGCC ACCCCGAGGA GCTGGTGCTG CTCGGACACT CTCTGGGCAT CCCCTGGGCT 720 CCCCTGAGCT CCTGCCCCAG CCAGGCCCTG CAGCTGGCAG GCTGCTTGAG CCAACTCCAT 780 AGCGGCCTTT TCCTCTACCA GGGGCTCCTG CAGGCCCTGG AAGGGATATC CCCCGAGTTG 840 GGTCCCACCT TGGACACACT GCAGCTGGAC GTCGCCGACT TTGCCACCAC CATCTGGCAG 900 CAGATGGAAG AACTGGGAAT GGCCCCTGCC CTGCAGCCCA CCCAGGGTGC CATGCCGGCC 960 TTCGCCTCTG CTTTCCAGCG CCGGGCAGGA GGGGTCCTGG TTGCTAGCCA TCTGCAGAGC 1020 TTCCTGGAGG TGTCGTACCG CGTTCTACGC CACCITGCGC AGCCG 1065 (2)序列編號NO: 297資料： (i)序列特性： (A)長度：1110鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 297 GCTACACCAT TGGGCCCTGC CAGCTCCCTG CCCCAGAGCT TCCTGCTCAA GTCTTTAGAG 60 CAAGTGAGAA AGATCCAGGG CGATGGCGCA GCGCTCCAGG AGAAGCTGTG TGCCACCTAC 120 AAGCTGTGCC ACCCCGAGGA GCTGGTGCTG CTCGGACACT CTCTGGGCAT CCCCTGGGCT 180 CCCCTGAGCT CCTGCCCCAG CCAGGCCCTG CAGCTGGCAG GCTGCTTGAG CCAACTCCAT 240 AGCGGCCTTT TCCTCTACCA GGGGCTCCTG CAGGCCCTGG AAGGGATATC CCCCGAGTTG 300 GGTCCCACCT TGGACACACT GCAGCTGGAC GTCGCCGACT TTGCCACCAC CATCTGGCAG 360 CAGATGGAAG AACTGGGAAT GGCCCCTGCC CTGCAGCCCA CCCAGGGTGC CATGCCGGCC 420 TTCGCCTCTG CTTTCCAGCG CCGGGCAGGA GGGGTCCTGG TTGCTAGCCA TCTGCAGAGC 480 TTCCTGGAGG TGTCGTACCG CGHCTACGC CACCTTGCGC AGCCCTACGT AGAGGGCGGT 540 GGAGGCTCCC CGGGTGAACC GTCTGGTCCA ATCTCTACTA TCAACCCGTC TCCTCCGTCT 600 AAAGAATCTC ATAAATCTCC AAACATGGCT GATGAAGAAC TGTGTGGTGG TCTGTGGCGG 660 CTGGTCCTGG CACAGCGCTG GATGGAGCGG CTCAAGACTG TCGCTGGGTC CAAGATGCAA 720 GGCTTGCTGG AGCGCGTGAA CACGGAGATA CACTTTGTCA CCAAATCTGC CTTTCAGCCC 780 CCCCCCAGCT GTCTTCGCTT CGTCCAGACC AACATCTCCC GCCTCCTGCA GGAGACCTCC 840 GAGCAGCTGG TGGCGCTGAA GCCCTGGATC ACTCGCCAGA ACTTCTCCCG GTGCCTGGAG 900 CTGCAGTGTC AGCCCGACTC CTCAACCCTG GGCGGTGGGT CAGGAGGTGG GTCAGGAGGT 960 GGATCCGGAG GTGGCTCAGG GGGAGGTAGT GGTACCCAGG ACTCCTCCTT CCAACACAGC 1020 CCCATCTCCT CCGACTTCGC TGTCAAAATC CGCGAGCTGT CTGACTACCT GCTTCAAGAT 1080 TACCCAGTCA CCGTGGCCTC CAACCTGCAG 1110

(2)序列編號NO: 298資料： (i)序列特性： (A)長度：1065鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 O:\92\92747.DOC -169- 200413407 (xi)序列描述：序列編號NO: 298 GCTGATGAAG AACTGTGTGG TGGTCTGTGG CGGCTGGTCC TGGCACAGCG CTGGATGGAG 60 CGGCTCAAGA CTGTCGCTGG GTCCAAGATG CAAGGCTTGC TGGAGCGCGT GAACACGGAG 120 ATACACTTTG TCACCAAATG TGCCTTTCAG CCCCCCCCCA GCTCTCTTCG CTTCGTCCAG 180 ACCAACATCT CCCGCCTCCT GCAGGAGACC TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG 240 ATCACTCGCC AGAACTTCTC CCGGTGCCTA GAGCTGCAGT CTCAGCCCGA CTCCTCAACC 300 CTGGGCGGTG GGTCAGGAGG TGGGTCAGGA GGTGGATCCG GAGGTGGCTC AGGGGGAGGT 360 AGTGGTACCC AGGACTGCTC CITCCAACAC AGCCCCATCT CCTCCGACTT CGCTGTCAAA 420 ATCCGTGAGC TGTCTGACTA CCTGCTTCAA GATTACCCAG TCACCGTGGC CTCCAACCTG 480 CAGTACGTAG AGGGCGGTGG AGGCTCCCCG GGTGGTGGTT CTGGCGGCGG CTCCAACATG 540 GCTACACCAT TGGGCCCTGC CAGCTCCCTG CCCCAGAGCT TCCTGCTCAA GTCTTTAGAG 600 CAAGTGAGAA AGATCCAGGG CGATGGCGCA GCGCTCCAGG AGAAGCTGTG TGCCACTAAC 660 AAGCTGTGCC ACCCCGAGGA GCTGGTGCTG CTCGGACACT CTCTGGGCAT CCCCTGGGCT 720 CCCCTG4GCT CCTGCCCCAG CCAGGCCCTG CAGCTGGCAG GCTGCTTGAG CCAACTCCAT 780 AGCGGCCTTT TCCTCTACCA GGGGCTCCTG CAGGCCCTGG AAGGGATATC CCCCGAGTTG 840 GGTCCCACCT TGGACACACT GCAGCTGGAC GTCGCCGACT TTGCCACCAC CATCTGGCAG 900 CAGATGGAAG AACTGGGAAT GGCCCCTGCC CTGCAGCCCA CCCAGGGTGC CATGCCGGCC 960 TTCGCCTCTG CTTTCCAGCG CCGGGCAGGA GGGGTCCTGG TTGCTAGCCA TCTGCAGAGC 1020 TTCCTGGAGG TGTCGTACCG CGTTCTACGC CACCTTGCGC AGCCG 1065 (2)序列編號NO: 299資料： (i)序列特性： (A) 長度：1110鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形

(xi)序列描述：序列編號NO: 299 GCTACACCAT TGGGCCCTGC CAGCTCCCTG CCCCAGAGCT TCCTGCTCAA GTCTTTAGAG 60 CAAGTGAGAA AGATCCAGGG CGATGGCGCA GCGCTCCAGG AGAAGCTGTG TGCCACCTAC 120 AAGCTGTGCC ACCCCGAGGA GCTGGTGCTG CTCGGACACT CTCTGGGCAT CCCCTGGGCT 180 CCCCTGAGCT CCTGCCCCAG CCAGGCCCTG CAGCTGGCAG GCTGCTTGAG CCAACTCCAT 240 AGCGGCCTTT TCCTCTACCA GGGGCTCCTG CAGGCCCTGG AAGGGATATC CCCCGAGTTG 300 GGTCCCACCT TGGACACACT GCAGCTGGAC GTCGCCGACT TTGCCACCAC CATCTGGCAG 360 CAGATGGAAG AACTGGGAAT GGCCCCTGCC CTGCAGCCCA CCCAGGGTGC CATGCCGGCC 420 TTCGCCTCTG CITTCCAGCG CCGGGCAGGA GGGGTCCTGG mCTkGCCk TCTGCAGAGC 480 TTCCTGGAGG TGTCGTACCG CGTTCTACGC CACCTTGCGC AGCCCTACGT AGAGGGCGGT 540 GGAGGCTCCC CGGGTGAACC GTCTGGTCCA ATCTCTACTA TCAACCCGTC TCCTCCGTCT 600 AAAGAATCTC ATAAATCTCC AAACATGGCA GATGAAGAAC TGTGTGGGGG CCTGTGGCGG 660 CTGGTCCTGG CACAGCGCTG GATGGAGCGG CTCAAGACTG TCGCTGGGTC CAAGATGCAA 720 GGCTTGCTGG AGCGCGTGAA CACGGAGATA CACTTTGTCA CCAAATGTGC CTTTCAGCCC 780 CCCCCCAGCT CTCTTCGCTT CGTCCAGACC AACATCTCCC GCCTCCTGCA GGAGACCTCC 840 GAGCAGCTGG TGGCGCTGAA GCCCTGGATC ACTCGCCAGA ACTTCTCCCG GTGCCTGGAG 900 CTGCAGTCTC AGCCCGACTC CTCAACCCTG GGCGGTGGGT CAGGAGGTGG GTCAGGAGGT 960 GGATCCGGAG GTGGCTCAGG GGGAGGTAGT (3GTACTCAGG ACTGTTCTTT TCAACACAGC 1020 CCCATCTCCT CCGACTTCGC TGTCAAAATC CGTGAGCTGT CTGACTACCT GCTTCAAGAT 1080 O:\92\92747.DOC -170- 200413407 1110

TACCCAGTCA CCGTGGCCTC CAACCTGCAG (2)序列編號NO: 300資料： (i)序列特性： (A)長度：1002鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 300 GCCACTCAGG actcctctit TCAACACAGC CCCATCTCCT CCGACTTCGC TGTCAAAATC 60 CGTGAGCTGT CTGACTACCT GCTTCAAGAT TACCCAGTCA CCGTGGCCTC CAACCTGCAG 120 GACGAGGAGC TCTGCGGGGG CCTCTGGCGG CTGGTCCTGG CACAGCGCTG GATGGAGCGG 180 CTCAAGACTG TCGCTGGGTC CAAGATGCAA GGCTTGCTGG AGCGCGTGAA CACGGAGATA 240 CACTTTGTCA CCAAATCTGC CHTCAGCCC CCCCCCAGCT GTCTTCGCTT CGTCCAGACC 300 AACATCTCCC GCCTCCTGCA GGAGACCTCC GAGCAGCTGG TGGCGCTGAA GCCCTGGATC 360 ACTCGCCAGA ACTTCTCCCG GTGCCTGGAG CTGCAGTGTC AGCCCGACTC CTCAACCCTG 420 TACGTAGAGG GCGGTGGAGG CTCCCCGGGT GGTGGTTCTG GCGGCGGCTC CAACATGGCT 480 ACACCATTGG GCCCTGCCAG CTCCCTGCCC CAGAGCITCC TGCTCAAGTC TTTAGAGCAA 540 GTGAGAAAGA TCCAGGGCGA TGGCGCAGCG CTCCAGGAGA AGCTGTGTGC CACTAACAAG 600 CTGTGCCACC CCGAGGAGCT GGTGCTGCTC GGACACTCTC TGGGCATCCC CTGGGCTCCC 660 CTGAGCTCCT GCCCCAGCCA GGCCCTGCAG CTGGCAGGCT GCTTGAGCCA ACTCCATAGC 720 GGCCTTTTCC TCTACCAGGG GCTCCTGCAG GCCCTGGAAG GGATATCCCC CGAGTTGGGT 780 CCCACCTTGG ACACACTGCA GCTGGACGTC GCCGACTTTG CCACCACCAT CTGGCAGCAG 840 ATGGAAGAAC TGGGAATGGC CCCTGCCCTG CAGCCCACCC AGGGTGCCAT GCCGGCCTTC 900 GCCTCTGCTT TCCAGCGCCG GGCAGGAGGG GTCCTGGTTG CTAGCCATCT GCAGAGCTTC 960 CTC5GAGGTGT CGTACCGCGT TCTACGCCAC CTTGCGCAGC CG 1002 (2)序列編號NO·. 301資料 • (i)序列特性： (A)長度：1002鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 301 GCCACTCAGG ACTGTTCTTT TCAACACAGC CCCATCTCCT CCGACTTCGC TGTCAAAATC 60 CGTGAGCTGT CTGACTACCT GCTTCAAGAT TACCCAGTCA CCGTGGCCTC CAACCTGCAG 120 GACGAGGAGC TCTGCGGGGG CCTCTGGCGG CTGGTCCTGG CACAGCGCTG GATGGAGCGG 180 CTCAAGACTG TCGCTGGGTC CAAGATGCAA GGCTTGCTGG AGCGCGTGAA CACGGAGATA 240 CACTTTGTCA CCAAATGTGC CTTTCAGCCC CCCCCCAGCT CTCTTCGCTT CGTCCAGACC 300 AACATCTCCC GCCTCCTGCA GGAGACCTCC GAGCAGCTGG TGGCGCTGAA GCCCTGGATC 360

O:\92\92747.DOC -171- 200413407 ACTCGCCAGA ACTTCTCCCG GTGCCTGGAG CTGCAGTCTC AGCCCGACTC CTCAACCCTG 420 TACGTAGAGG GCGGTGGAGG CTCCCCGGGT GGTGGTTCTG GCGGCGGCTC CAACATGGCT 480 ACACCATTGG GCCCTGCCAG CTCCCTGCCC CAGAGCTTCC TGCTCAAGTC TTTAGAGCAA 540 GTGAGAAAGA TCCAGGGCGA TGGCGCAGCG CTCCAGGAGA AGCTGTGTGC CACCTACAAG 600 CTGTGCCACC CCGAGGAGCT GGTGCTGCTC GGACACTCTC TGGGCATCCC CTGGGCTCCC 660 CTGAGCTCCT GCCCCAGCCA GGCCCTGCAG CTGGCAGGCT GCTTGAGCCA ACTCCATAGC 720 GGCCTTTTCC TCTACCAGGG GCTCCTGCAG GCCCTGGAAG GGATATCCCC CGAGTTGGGT 780 CCCACCTTGG ACACACTGCA GCTGGACGTC GCCGACTTTG CCACCACCAT CTGGCAGCAG 840 ATGGAAGAAC TGGGAATGGC CCCTGCCCTG CAGCCCACCC AGGGTGCCAT GCCGGCCTTC 900 GCCTCTGCTT TCCAGCGCCG GGCAGGAGGG GTCCTGGTTG CTAGCCATCT GCAGAGCTTC 960 CTGGAGGTGT CGTACCGCGT TCTACGCCAC CTTGCGCAGC CG 1002 (2)序列編號NO: 302資料： ⑴序列特性：

(A) 長度：978鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 302 GCCACTCAGG ACTGrrCTTT TCAACACAGC CCCATCTCCT CCGACTTCGC TGTCAAAATC 60 CGTGAGCTGT CTGACTACCT GCTTCAAGAT TACCCAGTCA CCGTGGCCTC CAACCTGCAG 120 GACGAGGAGC TCTGCGGGGG CCTCTGGCGG CTGGTCCTGG CACAGCGCTG GATGGAGCGG 180 CTCAAGACTG TCGCTGGGTC CAAGATGCAA GGCTTGCTGG AGCGCGTGAA CACGGAGATA 240 CACTTTGTCA CCAAATGTGC CTTTCAGCCC CCCCCCAGCT GTCTTCGCTT CGTCCAGACC 300 AACATCTCCC GCCTCCTGCA GGAGACCTCC GAGCAGCTGG TGGCGCTGAA GCCCTGGATC 360 ACTCGCCAGA ACTTCTCCCG GTGCCTGGAG CTGCAGTACG TAGAGGGCGG TGGAGGCTCC 420 CCGGGTGGTG GTTCTGGCGG CGGCTCCAAC ATGGCTACAC CATTGGGCCC TGCCAGCTCC 480 CTGCCCCAGA GCTTCCTGCT CAAGTCTTTA GAGCAAGTGA GAAAGATCCA GGGCGATGGC 540 GCAGCGCTCC AGGAGAAGCT GTGTGCCACT AACAAGCTGT GCCACCCCGA GGAGCTGGTG 600 CTGCTCGGAC ACTCTCTGGG CATCCCCTGG GCTCCCCTGA GCTCCTGCCC CAGCCAGGCC 660 CTGCAGCTGG CAGGCTGCTT GAGCCAACTC CATAGCGGCC mTCCTCTA CCAGGGGCTC 720 CTGCAGGCCC TGGAAGGGAT ATCCCCCGAG nGGGTCCCA CCTTGGACAC ACTGCAGCTG 780 GACGTCGCCG ACTTTGCCAC CACCATCTGG CAGCAGATGG AAGAACTGGG AATGGCCCCT 840 GCCCTGCAGC CCACCCAGGG TGCCATGCCG GCCITCGCCT CTGCTTTCCA GCGCCGGGCA 900 GGAGGGGTCC TGGTTGCTAG CCATCTGCAG AGOTCCTGG AGGTGTCGTA CCGCGTTCTA 960 CGCCACCTTG CGCAGCCG 978 (2)序列編號NO·· 303資料 •

⑴序列特性： (A) 長度：1002鹼基對 (B) 形式：核酸 (C) 股數：單 O:\92\92747.DOC -172- 200413407 (D)拓撲結構：線形 (xi)序列描述：序列編號NO: 303 GCCACTCAGG ACTGTTCTTT TCAACACAGC CCCATCTCCT CCGACTTCGC TGTCAAAATC 60 CGTGAGCTGT CTGACTACCT GCTTCAAGAT TACCCAGTCA CCGTGGCCTC CAACCTGCAG 120 GACGAGGAGC TCTGCGGGGG CCTCTGGCGG CTGGTCCTGG CACAGCGCTG GATGGAGCGG 180 CTCAAGACTG TCGCTGGGTC CAAGATGCAA GGCTTGCTGG AGCGCGTGAA CACGGAGATA 240 CACTTTGTCA CCAAATGTGC CTTTCAGCCC CCCCCCAGCT GTCTTCGCTT CGTCCAGACC 300 AACATCTCCC GCCTCCTGCA GGAGACCTCC GAGCAGCTGG TGGCGCTGAA GCCCTGGATC 360 ACTCGCCAGA ACTTCTCCCG GTGCCTGGAG CTGCAGTCTC AGCCCGACTC CTCAACCCTG 420 TACGTAGAGG GCGGTGGAGG CTCCCCGGGT GGTGGTTCTG GCGGCGGCTC CAACATGGCT 480 ACACCATTGG GCCCTGCCAG CTCCCTGCCC CAGAGCTTCC TGCTCAAGTC TTTAGAGCAA 540 GTGAGAAAGA TCCAGGGCGA TGGCGCAGCG CTCCAGGAGA AGCTGTGTGC CACCTACAAG 600 CTGTGCCACC CCGAGGAGCT GGTGCTGCTC GGACACTCTC TGGGCATCCC CTGGGCTCCC 660 CTGAGCTCCT GCCCCAGCCA GGCCCTGCAG CTGGCAGGCT GCTTGAGCCA ACTCCATAGC 720 GGCCTTTTCC TCTACCAGGG GCTCCTGCAG GCCCTGGAAG GGATATCCCC CGAGTTGGGT 780 CCCACCTTGG ACACACTGCA GCTGGACGTC GCCGACTTTG CCACCACCAT CTGGCAGCAG 840 ATGGAAGAAC TGGGAATGGC CCCTGCCCTG CAGCCCACCC AGGGTGCCAT GCCGGCCTTC 900 GCCTCTGCTT TCCAGCGCCG GGCAGGAGGG GTCCTGGTTG CTAGCCATCT GCAGAGCTTC 960 CTGGAGGTGT CGTACCGCGT TCTACGCCAC CTTGCGCAGC CG 1002 (2)序列編號NO: 304資料：

⑴序列特性： (A) 長度：1001鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 304 φ GCCACTCAGG ACTGTTCnT TCAACACAGC CCCATCTCCT CCGACTTCGC TGTCAAAATC 60 CGTGAGCTGT CTGACTACCT GCTTCAAGAT TACCCAGTCA CCGTGGCCTC CAACCTGCAG 120 GACGAGGAGC TCTGCGGGGG CCTCTGGCGG CTGGTCCTGG CACAGCGCTG GATGGAGCGG 180 CTCAAGACTG TCGCTGGGTC CAAGATGCAA GGCTTGCTGG AGCGCGTGAA CACGGAGATA 240 CACTTTGTCA CCAAATGTGC CTTTCAGCCC CCCCCCAGCT GTCTTCGCTT CGTCCAGACC 300 AACATCTCCC GCCTCCTGCA GGAGACCTCC GAGCAGCTGG TGGCGCTGAA GCCCTGGATC 360 ACTCGCCAGA ACTTCTCCCG GCGCCTGGAG CTGCAGTCTC AGCCCGACTC CTCAACCCTG 420 TACGTAGAGG GCGGTGGAGG CTCCCCGGGT GGTGGTTCTG GCGGCGGCTC CAACATGGCT 480 ACACCATTGG GCCCTGCCAG CTCCCTGCCC CAGAGCTTCC TGCTCAAGTC TTTAGAGCAA 540 GTGAGAAAGA TCCAGGGCGA TGGCGCAGCG CTCCAGGAGA AGCTGTGTGC CACTAACAAG 600 CTGTGCCACC CCGAGGAGCT GGTGCTGCTC GGACACTCTC TGGGCATCCC CTGGGCTCCC 660 CTGAGCTCCT GCCCCAGCCA GGCCCTGCAG CTGGCAGGCT GCTTGAGCCA ACTCCATAGC 720 GGCCTTTTCC TCTACCAGGG GCTCCTGCAG GCCCTGGAAG GGATATCCCC CGAGHGGGT 780 CCCACCTTGG ACACACTGCA GCTGGACGTC GCCGACTTTG CCACCACCAT CTGGCAGCAG 840 ATGGAAGAAC TGGGAATGGC CCCTGCCCTG CAGCCCACCC AGGGTGCCAT GCCGGCCTTC 900 GCCTCTGCTT TCCAGCGCCG GGCAGGAGGG GTCCTGGITG CTAGCCATCT GCAGAGCTTC 960 CTGGAGGTGT CGTACCGCGT TCTACGCCAC CTTGCGCAGC C 1001 O:\92\92747.DOC -173- 200413407 (2)序列編號NO: 305資料： (i)序列特性： (A) 長度：1056鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 305

GCTGATGAAG AACTGTGTGG TGGTCTGTGG CGGCTGGTCC TGGCACAGCG CTGGATGGAG 60 CGGCTCAAGA CTGTCGCTGG GTCCAAGATG CAAGGCTTGC TGGAGCGCCT GAACACGGAG 120 ATACAC7TTG TCACCAAATG TGCCITTCAG CCCCCCCCCA GCTGTCTTCG CTTCGTCCAG 180 ACCAACATCT CCCGCCTCCT GCAGGAGACC TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG 240 ATCACTCGCC AGAACTTCTC CCGGTGCCTG GAGCTGCAGT GTCAGCCCGA CTCCTCAACC 300 CTGGGCGGTG GGTCAGGAGG TGGGTCAGGA CGTGGATCCG GAGGTGGCTC AGGGGGAGGT 360 AGTGGTACCC AGGACTGCTC CTTCCAACAC AGCCCCATCT CCTCCGACIT CGCTGTCAAA 420 ATCCGTGAGC TGTCTGACTA CCTGCTTCAA GATTACCCAG TCACCGTGGC CTCCAACCTG 480 CAGTACGTAG AGGGCGGTGG AGGCTCCCCG GGTGGTGCTT CTGGCGGCGG CTCCAACATG 540 GCTACTCAAG GTGCTATGCC AGCTTTTGCT TCTGCmTC AACGTCGTGC AGGTGGTGTT 600 CTGGTTGCTA GCCATCTGCA GAGCTTCCTG GAGGTGTCGT ACCGCGTTCT ACGCCACCTT 660 GCGCAGCCCT CTGGCGGCTC TGGCGGCTCT CAGAGCTTCC TGCTCAAGTC TTTAGAGCAA 720 GTGAGAAAGA TCCAGGGCGA TGGCGCAGCG CTCCAGGAGA AGCTGTGTGC CACCTACAAG 780 CTGTGCCACC CCGAGGAGCT GGTGCTGCTC GGACACTCTC TGGGCATCCC CTGGGCTCCC 840 CTGAGCTCCT GCCCCAGCCA GGCCCTGCAG CTGGCAGGCT GOTGACCCA ACTCCATAGC 900 GGCCTTTTCC TCTACCAGGG GCTCCTGCAG GCCCTGGAAG GGATATCCCC CGAGTTGGGT 960 CCCACCITGG ACACACTGCA GCTGGACGTC GCCGACTTTG CCACCACCAT CTGGCAGCAG 1020 ATGGAAGAAC TGGGAATGGC CCCTGCCCTG CAGCCC 1056 (2)序列編號NO·· 306資料： (i)序列特性： (A)長度：1101鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO·. 306 GCTACTCAAG GTGCTATGCC AGCTITTGCT TCTGCTTTTC AACGTCGTGC AGGTGGTGTT 60 CTGGTTGCTA GCCATCTGCA GAGCTTCCTG GAGGTGTCGT ACCGCGHCT ACGCCACCTT 120 GCGCAGCCCT CTGGCGGCTC TGGCGGCTCT CAGAGCTTCC TGCTCAAGTC TTTAGAGCAA 180 GTGAGAAAGA TCCAGGGCGA TGGCGCAGCG CTCCAGGAGA AGCTGTGTGC CACCTACAAG 240 CTGTGCCACC CCGAGGAGCT GGTGCTGCTC GGACACTCTC TGGGCATCCC CTGGGCTCCC 300 CTGAGCTCCT GCCCCAGCCA GGCCCTGCAG CTGGCAGGCT GCTTGAGCCA ACTCCATAGC 360 O:\92\92747.DOC -174- 200413407

GGCCTTTTCC TCTACCAGGG GCTCCTGCAG GCCCTGGAAG GGATATCCCC CGAGTTGGGT CCCACCTTGG ACACACTGCA GCTGGACGTC GCCGACTTTG CCACCACCAT CTGGCAGCAG ATGGAAGAAC TGGGAATGGC CCCTGCCCTG CAGCCCTACG TAGAGGGCGG TGGAGGCTCC CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT CATAAATCTC CAAACATGGC CGACGAGGAG CTCTGCGGGG GCCTCTGGCG GCTGGTCCTG GCACAGCGCT GGATGGAGCG GCTCAAGACT GTCGCTGGGT CCAAGATGCA AGGCITGCTG GAGCGCGTGA ACACGGAGAT ACACTTTGTC ACCAAATGTG CCTTTCAGCC CCCCCCCAGC TGTCTTCGCT TCGTCCAGAC CAACATCTCC CGCCTCCTGC AGGAGACCTC CGAGCAGCTG GTGGCGCTGA AGCCCTGGAT CACTCGCCAG AACTTCTCCC GGTGCCTGGA GCTGCAGTGT CAGCCCGACT CCTCAACCCT GGGCGGTGGG TCAGGAGGTG GGTCAGGAGG TGGATCCGGA GGTGGCTCAG GGGGAGGTAG TGGTACCCAG GACTGCTCCT TCCAACACAG CCCCATCTCC TCCGACTTCG CTGTCAAAAT cCGTGAGCTG TCTGACTACC TGCTTCAAGA TTACCCAGTC ACCGTGGCCT CCAACCTGCA G ο ο 1

0000000000280 2840628406001 4 4 5 6 6 7 7 8 9 9 ^—_ -—II (2)序列編號NO: 307資料： (i)序列特性： (A) 長度：1032鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 307

GCCGACGAGG AGCTGTGCGG TGGCCTCTGG CGGCTGGTCC TGGCACAGCG CTGGATGGAG CGGCTCAAGA CTGTCGCTGG GTCCAAGATG CAAGGCTTGC TGGAGCGCGT GAACACGGAG ATACACTITG TCACCAAATG TGCCTTTCAG CCCCCCCCCA GCTGTCTTCG CTTCGTCCAG ACCAACATCT CCCGCCTCCT CCAGGAGACC TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG ATCACTCGCC AGAACTTCTC CCGGTGCCTG GAGCTGCAGT GTCAGCCCGA CTCCTCAACC CTGGGCGGTG GGTCAGGAGG TGGGTCAGGA GGTGGATCCG GAGGTGGAAC CCAGGACTGC TCCTTCCAAC ACAGCCCCAT CTCCTCCGAC TTCGCTGTCA AAATCCGTGA GCTGTCTGAC TACCTGCTTC AAGATTACCC AGTCACCGTG GCCTCCAACC TGCAGTACGT AGAGGGCGGT GGAGGCTCCC CGGGTGAACC GTCTGGTCCA ATCTCTACTA TCAACCCGTC TCCTCCGTCT AAAGAATCTC ATAAATCTCC AAACATGGCC GACGAGGAGC TCTGCGGGGG CCTCTGGCGG CTGGTCCTGG CACAGCGCTG GATGGAGCGG CTCAAGACTG TCGCTGGGTC CAAGATGCAA GGCTTGCTGG AGCGCGTGAA CACGGAGATA CACTTTGTCA CCAAATGTGC CTTTCAGCCC cccccCAGCT GTCTTCGCTT CGTCCAGACC AACATCTCCC GCCTCCTCCA GGAGACCTCC GAGCAGCTGG TGGCGCTGAA CCCCTGGATC ACTCGCCAGA ACTTCTCCCG GTGCCTGGAG CTGCAGTGTC AGCCCGACTC CTCAACCCTG GGCGGTGGGT CAGGAGGTGG GTCAGGAGGT GGATCCGGAG GTGGCACCCA GGACTCCTCC TOCAACACA GCCCCATCTC CTCCGACTTC GCTGTCAAAA TCCGTGAGCT GTCTGACTAC CTGCTTCAAG ATTACCCAGT CACCGTGGCC TCCAACCTGC AG C 广2 00000000000000023 028406284062840600 6 .—-10^3344566778991.—_ (2)序列編號NO: 308資料： (i)序列特性： (A) 長度：1005鹼基對 (B) 形式：核酸 O:\92\92747.DOC -175- 200413407 (c)股數：單 (D)拓撲結構：線形 (xi)序列描述：序列編號NO: 308 GCTGATGAAG AACTGTGTGG TGGTCTGTGG CGGCTGGTCC TGGCACAGCG CTGGATGGAG 60 CGGCTCAAGA CTGTCGCTGG GTCCAAGATG CAAGGCTTGC TGGAGCGCGT GAACACGGAG 120 ATACACTTTG TCACCAAATG TGCCTTTCAG CCCCCCCCCA GCTGTCTTCG CTTCGTCCAG 180 ACCAACATCT CCCGCCTCCT GCAGGAGACC TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG 240 ATCACTCGCC AGAACTTCTC CCGGTGCCTG GAGCTGCAGT GTCAGCCCGA CTCCTCAACC 300 CTGGGCGGTG GGTCAGGAGG TGGGTCAGGA GGTGGATCCG GAGGTGGCTC AGGGGGAGGT 360 AGTGGTACCC AGGACTGCTC CTTCCAACAC AGCCCCATCT CCTCCGACTT CGCTGTCAAA 420 ATCCGTGAGC TGTCTGACTA CCTGCTTCAA GATTACCCAG TCACCGTGGC CTCCAACCTG 480 CAGTACGTAG AGGGCGGTGG AGGCTCCCCG GGTGAACCGT CTGGTCCAAT CTCTACTATC 540 AACCCGTCTC CTCCGTCTAA AGAATCTCAT AAATCTCCAA ACATGGCTAC CCAGGACTGC 600 TCCTTCCAAC ACAGCCCCAT CTCCTCCGAC TTCGCTGTCA AAATCCGTGA GCTGTCTGAC 660 TACCTGCTTC AAAATTACCC AGTCACCGTG GCCTCCAACC TGCAGGACGA GGAGCTCTGC 720 GGGGGCCTCT GGCGGCTGGT CCTGGCACAG CGCTGGATGG AGCGGCTCAA GACTGTCGCT 780 GGGTCCAAGA TGCAAGGCTT GCTGGAGCGC GTGAACACGG AGATACACTT TGTCACCAAA 840 TGTGCCTTTC AGCCCCCCCC CAGCTGTCTT CGCTTCGTCC AGACCAACAT CTCCCGCCTC 900 CTGCAGGAGA CCTCCGAGCA GCTGGTGGCG CTGAAGCCCT GGATCACTCG CCAGAACTTC 960 TCCCGGTGCC TGGAGCTGCA GTGTCAGCCC GACTCCTCAA CCCTG 1005 (2)序列編號NO: 309資料： ⑴序列特性： (A) 長度：1650鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 309 GCTGATGAAG AACTGTGTGG TGGTCTGTGG CGGCTGGTCC TGGCACAGCG CTGGATGGAG 60 CGGCTCAAGA CTGTCGCTGG GTCCAAGATG CAAGGCTTGC TGGAGCGCGT GAACACGGAG 120 ATACACTTTG TCACCAAATG TGCCTTTCAG CCCCCCCCCA GCTGTCTTCG CTTCGTCCAG 180 ACCAACATCT CCCGCCTCCT GCAGGAGACC TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG 240 ATCACTCGCC AGAACTTCTC CCGGTGCCTG GAGCTGCAGT GTCAGCCCGA CTCCTCAACC 300 CTGGGCGGTG GGTCAGGAGG TGGGTCAGGA GGTGGATCCG GAGGTGGCTC AGGGGGAGGT 360 AGTGGTACCC AGGACTGCTC CTTCCAACAC AGCCCCATCT CCTCCGACTT CGCTGTCAAA 420 ATCCGTGAGC TGTCTGACTA CCTGCTTCAA GAmCCCAG TCACCGTGGC CTCCAACCTG 480 CAGTACGTAG AGGGCGGTGG AGGCTCCCCG GGTGGTGGTT CTGGCGGCGG CTCCAACATG 540 GCTACACCAT TGGGCCCTGC CAGCTCCCTG CCCCAGAGCT TCCTGCTCAA GTCTTTAGAG 600 CAAGTGAGAA AGATCCAGGG CGATGGCGCA GCGCTCCAGG AGAAGCTGTG TGCCACCTAC 660 AAGCTGTGCC ACCCCGAGGA GCTGGTGCTG CTCGGACACT CTCTGGGCAT CCCCTGGGCT 720 CCCCTGAGCT CCTGCCCCAG CCAGGCCCTG CAGCTGGCAG GCTGCTTGAG CCAACTCCAT 780 AGCGGCCTTT TCCTCTACCA GGGGCTCCTG CAGGCCCTGG AAGGGATATC CCCCGAGTTG 840 GGTCCCACCT TGGACACACT GCAGCTGGAC GTCGCCGACT TTGCCACCAC CATCTGGCAG 900 CAGATGGAAG AACTGGGAAT GGCCCCTGCC CTGCAGCCCA CCCAGGGTGC CATGCCGGCC 960 O:\92\92747.DOC -176 200413407 TTCGCCTCTG CTTTCCAGCG CCGGGCAGGA GGGGTCCTGG TTGCTAGCCA TCTGCAGAGC 1020 TTCCTGGAGG TGTCGTACCG CGTTCTACGC CACCTTGCGC AGCCCTACGT AGAGGGCGGT 1080 GGAGGCTCCC CGGGTGAACC GTCTGGTCCA ATCTCTACTA TCAACCCGTC TCCTCCGTCT 1140 AAAGAATCTC ATAAATCTCC AAACATGGCT GATGAAGAAC TGTGTGGTGG TCTGTGGCGG 1200 CTGGTCCTGG CACAGCGCTG GATGGAGCGG CTCAAGACTG TCGCTGGGTC CAAGATGCAA 1260 GGCTTGCTGG AGCGCGTGAA CACGGAGATA CACTTTGTCA CCAAATGTGC CTTTCAGCCC 1320 CCCCCCAGCT GTCTTCGCTT CGTCCAGACC AACATCTCCC GCCTCCTGCA GGAGACCTCC 1380 GAGCAGCTGG TGGCGCTGAA GCCCTGGATC ACTCGCCAGA ACTTCTCCCG GTGCCTGGAG 1440 CTGCAGTGTC AGCCCGACTC CTCAACCCTG GGCGGTGGGT CAGGAGGTGG GTCAGGAGGT 1500 GGATCCGGAG GTGGCTCAGG GGGAGGTAGT GGTACCCAGG ACTGCTCCTT CCAACACAGC 1560 CCCATCTCCT CCGACTTCGC TGTCAAAATC CGTGAGCTGT CTGACTACCT GCTTCAAGAT 1620 TACCCAGTCA CCGTGGCCTC CAACCTGCAG 1650 (2)序列編號NO: 310資料： (i)序列特性： (A) 長度：1632鹼基對籲 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 310

GCTACACCAT TGGGCCCTGC CAGCTCCCTG CCCCAGAGCT TCCTGCTCAA GTCTTTAGAG 60 CAAGTGAGAA AGATCCAGGG CGATGGCGCA GCGCTCCAGG AGAAGCTGTG TGCCACCTAC 120 AAGCTGTGCC ACCCCGAGGA GCTGGTGCTG CTCGGACACT CTCTGGGCAT CCCCTGGGCT 180 CCCCTGAGCT CCTGCCCCAG CCAGGCCCTG CAGCTGGCAG GCTGCTTGAG CCAACTCCAT 240 AGCGGCCTTT TCCTCTACCA GGGGCTCCTG CAGGCCCTGG AAGGGATATC CCCCGAGTTG 300 GGTCCCACCT TGGACACACT GCAGCTGGAC GTCGCCGACT TTGCCACCAC CATCTGGCAG 360 CAGATGGAAG AACTGGGAAT GGCCCCTGCC CTGCAGCCCA CCCAGGGTGC CATGCCGGCC 420 TTCGCCTCTG CTTTCCAGCG CCGGGCAGGA GGGGTCCTGG TTGCTAGCCA TCTGCAGAGC 480 TTCCTGGAGG TGTCGTACCG CGTTCTACGC CACCTTGCGC AGCCCTACGT AGAGGGCGGT 540 GGAGGCTCCC CGGGTGAACC GTCTGGTCCA ATCTCTACTA TCAACCCGTC TCCTCCGTCT 600 AAAGAATCTC ATAAATCTCC AAACATGGCT GATGAAGAAC TGTGTGGTGG TCTGTGGCGG 660 CTGGTCCTGG CACAGCGCTG GATGGAGCGG CTCAAGACTG TCGCTGGGTC CAAGATGCAA 720 GCCTTGCTGG AGCGCGTGAA CACGGAGATA CACTTTGTCA CCAAATGTGC CTTTCAGCCC 780 CCCCCCAGCT GTCTTCGCTT CGTCCAGACC AACATCTCCC GCCTCCTGCA GGAGACCTCC 840 GAGCAGCTGG TGGCGCTGAA GCCCTGGATC ACTCGCCAGA ACTTCTCCCG GTGCCTGGAG 900 CTGCAGTGTC AGCCCGACTC CTCAACCCTG GGCGGTGGGT CAGGAGGTGG GTCAGGAGGT 960 GGATCCGGAG GTGGCTCAGG GGGAGGTAGT GGTACCCAGG ACTGCTCCTT CCAACACAGC 1020 CCCATCTCCT CCGACTTCGC TGTCAAAATC CGTGAGCTGT CTGACTACCT GCTTCAAGAT 1080 TACCCAGTCA CCGTGGCCTC CAACCTGCAG TACGTAGAGG GCGGTGGAGG CTCCCCGGGT 1140 GAACCGTCTG GTCCAATCTC TACTATCAAC CCGTCTCCTC CGTCTAAAGA ATCTCATAAA 1200 TCTCCAAACA TGGCTACCCA GGACTGCTCC TTCCAACACA GCCCCATCTC CTCCGACTTC 1260 GCTGTCAAAA TCCGTGAGCT GTCTGACTAC CTGCTTCAAG ATTACCCAGT CACCGTGGCC 1320 TCCAACCTGC AGGACGAGGA GCTCTGCGGG GGCCTCTGGC GGCTGGTCCT GGCACAGCGC 1380 TGGATGGAGC GGCTCAAGAC TGTCGCTGGG TCCAAGATGC AAGGCTTGCT GGAGCGCGTG 1440 AACACGGAGA TACACTTTGT CACCAAATGT GCCTTTCAGC CCCCCCCCAG CTGTCTTCGC 1500 TTCGTCCAGA CCAACATCTC CCGCCTCCTG CAGGAGACCT CCGAGCAGCT GGTGGCGCTG 1560 AAGCCCTGGA TCACTCGCCA GAACTTCTCC CGGTGCCTGG AGCTGCAGTG TCAGCCCGAC 1620 O:\92\92747.DOC -177 1632

TCCTCAACCC TG (2)序列編號NO: 311資料： (i)序列特性： (A) 長度：1695鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 311 GCTACACCAT TGGGCCCTGC CAGCTCCCTG CCCCAGAGCT TCCTGCTCAA GTCTTTAGAG 60 CAAGTGAGAA AGATCCAGGG CGATGGCGCA GCGCTCCAGG AGAAGCTGTG TGCCACCTAC 120 AAGCTGTGCC ACCCCGAGGA GCTGGTGCTG CTCGGACACT CTCTGGGCAT CCCCTGGGCT 180 CCCCTGAGCT CCTGCCCCAG CCAGGCCCTG CAGCTGGCAG GCTGCTTGAG CCAACTCCAT 240 AGCGGCCTTT TCCTCTACCA GGGGCTCCTG CAGGCCCTGG AAGGGATATC CCCCGAGTTG 300 GGTCCCACCT TGGACACACT GCAGCTGGAC GTCGCCGACT HGCCACCAC CATCTGGCAG 360 CAGATGGAAG AACTGGGAAT GGCCCCTGCC CTGCAGCCCA CCCAGGGTGC CATGCCGGCC 420 TTCGCCTCTG CTTTCCAGCG CCGGGCAGGA GGGGTCCTGG TTGCTAGCCA TCTGCAGAGC 480 TTCCTGGAGG TGTCGTACCG CGTTCTACGC CACCTTGCGC AGCCCTACGT AGAGGGCGGT 540 GGAGGCTCCC CGGGTGAACC GTCTGGTCCA ATCTCTACTA TCAACCCGTC TCCTCCGTCT 600 AAAGAATCTC ATAAATCTCC AAACATGGCT GATGAAGAAC TGTGTGGTGG TCTGTGGCGG 660 CTGGTCCTGG CACAGCGCTG GATGGAGCGG CTCAAGACTG TCGCTGGGTC CAAGATGCAA 720 GGCTTGCTGG AGCGCGTGAA CACGGAGATA CACTTTGTCA CCAAATGTGC CTTTCAGCCC 780 CCCCCCAGCT GTCTTCGCTT CGTCCAGACC AACATCTCCC GCCTCCTGCA GGAGACCTCC 840 GAGCAGCTGG TGGCGCTGAA GCCCTGGATC ACTCGCCAGA ACTTCTCCCG GTGCCTGGAG 900 CTGCAGTGTC AGCCCGACTC CTCAACCCTG GGCGGTGGGT CAGGAGGTGG GTCAGGAGGT 960 GGATCCGGAG GTGGCTCAGG GGGAGGTAGT GGTACCCAGG ACTGCTCCTT CCAACACAGC 1020 CCCATCTCCT CCGACTTCGC TGTCAAAATC CGTGAGCTGT CTGACTACCT GCTTCAAGAT 1080 TACCCAGTCA CCGTGGCCTC CAACCTGCAG TACGTAGAGG GCGGTGGAGG CTCCCCGGGT 1140 GAACCGTCTG GTCCAATCTC TACTATCAAC CCGTCTCCTC CGTCTAAAGA ATCTCATAAA 1200 TCTCCAAACA TGGCTGATGA AGAACTGTGT GGTGGTCTGT GGCGGCTGGT CCTGGCACAG 1260 CGCTGGATGG AGCGGCTCAA GACTGTCGCT GGGTCCAAGA TGCAAGGCTT GCTGGAGCGC 1320 GTGAACACGG AGATACACTT TGTCACCAAA TGTGCCnTC AGCCCCCCCC CAGCTGTCTT 1380 CGCTTCGTCC AGACCAACAT CTCCCGCCTC CTGCAGGAGA CCTCCGAGCA GCTGGTGGCG 1440 CTGAAGCCCT GGATCACTCG CCAGAACTTC TCCCGGTGCC TGGAGCTGCA GTGTCAGCCC 1500 GACTCCTCAA CCCTGGGCGG TGGGTCAGGA GGTGGGTCAG GAGGTGGATC CGGAGGTGGC 1560 TCAGGGGGAG GTAGTGGTAC CCAGGACTGC TCCTTCCAAC ACAGCCCCAT CTCCTCCGAC 1620 TTCGCTGTCA AAATCCGTGA GCTGTCTGAC TACCTGCTTC AAGATTACCC AGTCACCGTG 1680 GCCTCCAACC TGCAG 1695 (2)序列編號ΝΟ·β 312資料 ·· ⑴序列特性： (A) 長度：1506鹼基對 (B) 形式：核酸 O:\92\92747.DOC -178- 200413407 (c)股數：單 (D)拓撲結構：線形 (xi)序列描述：序列編號NO: 312 GCTAACTGCT CTATAATGAT CGATGAAATT ATACATCACT TAAAGAGACC ACCTGCACCT 60 TTGCTGGACC CGAACAACCT CAATGACGAA GACGTCTCTA TCCTGATGGA CCGAAACCTT 120 CGACTTCCAA ACCTGGAGAG CTTCGTAAGG GCTGTCAAGA ACTTAGAAAA TGCATCAGGT 180 ATTGAGGCAA TTCTTCGTAA TCTCCAACCA TGTCTGCCCT CTGCCACGGC CGCACCCTCT 240 CGACATCCAA TCATCATCAA GGCAGGTGAC TGGCAAGAAT TCCGGGAAAA ACTGACGTTC 300 TATCTGGTTA CCCTTGAGCA AGCGCAGGAA CAACAGTACG TAGAGGGCGG TGGAGGCTCC 360 CCGGGTGAAC CGTCTGGTCC AATCTCTACT ATCAACCCGT CTCCTCCGTC TAAAGAATCT 420 CATAAATCTC CAAACATGGC TGATGAAGAA CTGTGTGGTG GTCTGTGGCG GCTGGTCCTG 480 GCACAGCGCT GGATGGAGCG GCTCAAGACT GTCGCTGGGT CCAAGATGCA AGGCTTGCTG 540 GAGCGCGTGA ACACGGAGAT ACACTTTGTC ACCAAATGTG CCTITCAGCC CCCCCCCAGC 600 TGTCTTCGCT TCGTCCAGAC CAACATCTCC CGCCTCCTGC AGGAGACCTC CGAGCAGCTG 660 GTGGCGCTGA AGCCCTGGAT CACTCGCCAG AACITCTCCC GGTGCCTGGA GCTGCAGTGT 720 CAGCCCGACT CCTCAACCCT GGGCGGTGGG TCAGGAGGTG GGTCAGGAGG TGGATCCGGA 780 GGTGGCTCAG GGGGAGGTAG TGGTACCCAG GACTGCTCCT TCCAACACAG CCCCATCTCC 840 TCCGACTTCG CTGTCAAAAT CCGTGAGCTG TCTGACTACC TGCTTCAAGA TTACCCAGTC 900 ACCGTGGCCT CCAACCTGCA GTACGTAGAG GGCGGTGGAG GCTCCCCGGG TGAACCGTCT 960 GGTCCAATCT CTACTATCAA CCCGTCTCCT CCGTCTAAAG AATCTCATAA ATCTCCAAAC 1020 ATGGCTGATG AAGAACTGTG TGGTGGTCTG TGGCGGCTGG TCCTGGCACA GCGCTGGATG 1080 GAGCGGCTCA AGACTGTCGC TGGGTCCAAG ATGCAAGGCT TGCTGGAGCG CGTGAACACG 1140 GAGATACACT mTCKCCkk ATGTGCCTTT CAGCCCCCCC CCAGCTGTCT TCGCTTCGTC 1200 CAGACCAACA TCTCCCGCCT CCTGCAGGAG ACCTCCGAGC AGCTGGTGGC GCTGAAGCCC 1260 TGGATCACTC GCCAGAAOT CTCCCGGTGC CTGGAGCTGC AGTGTCAGCC CGACTCCTCA 1320 ACCCTGGGCG GTGGGTCAGG AGGTGGGTCA GGAGGTGGAT CCGGAGGTGG CTCAGGGGGA 1380 GGTAGTGGTA CCCAGGACTG CTCCTTCCAA CACAGCCCCA TCTCCTCCGA CTTCGCTGTC 1440 AAAATCCGTG AGCTGTCTGA CTACCTGCTT CAAGATTACC CAGTCACCGT GGCCTCCAAC 1500 CTGCAG 1506

(2)序列編號NO: 313資料： (i)序列特性： (A) 長度：1674鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 313 GCTGATGAAG AACTGTGTGG TGGTCTGTGG CGGCTGGTCC TGGCACAGCG CTGGATGGAG 600 CGGCTCAAGA CTGTCGCTGG GTCCAAGATG CAAGGCITGC TGGAGCGCGT GAACACGGAG 660 ATACACTTTG TCACCAAATG TGCCTTTCAG CCCCCCCCCA GCTGTCTTCG CITCGTCCAG 720 ACCAACATCT CCCGCCTCCT GCAGGAGACC TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG 780 ATCACTCGCC AGAACTTCTC CCGGTGCCTG GAGCTGCAGT GTCAGCCCGA CTCCTCAACC 840 CTGGGCGGTG GGTCAGGAGG TGGGTCAGGA GGTGGATCCG GAGGTGGCTC AGGGGGAGGT 900 AGTGGTACCC AGGACTGCTC CTTCCAACAC AGCCCCATCT CCTCCGACTT CGCTGTCAAA 960 O:\92\92747.DOC -179- 200413407 ATCCGTGAGC TGTCTGACTA CCTGCTTCAA GATTACCCAG TCACCGTGGC CTCCAACCTG 1020 CAGTACGTAG AGGGCGGTGG AGGCTCCCCG GGTGGTGGTT CTGGCGGCGG CTCCAACATG 540 GCTGATGAAG AACTGTGTGG TGGTCTGTGG CGGCTGGTCC TGGCACAGCG CTGGATGGAG 600 CGGCTCAAGA CTGTCGCTGG GTCCAAGATG CAAGGCTTGC TGGAGCGCGT GAACACGGAG 660 ATACACTTTG TCACCAAATG TGCCTTTCAG CCCCCCCCCA GCTGTCTTCG CTTCGTCCAG 720 ACCAACATCT CCCGCCTCCT GCAGGAGACC TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG 780 ATCACTCGCC AGAACTTCTC CCGGTGCCTG GAGCTGCAGT GTCAGCCCGA CTCCTCAACC 840 CTGGGCGGTG GGTCAGGAGG TGGGTCAGGA GGTGGATCCG GAGGTGGCTC AGGGGGAGGT 900 AGTGGTACCC AGGACTGCTC CTTCCAACAC AGCCCCATCT CCTCCGACTT CGCTGTCAAA 960 ATCCGTGAGC TGTCTGACTA CCTGCTTCAA GATTACCCAG TCACCGTGGC CTCCAACCTG 1020 CAGTACGTAG AGGGCGGTGG AGGCTCCCCG GGTGAACCGT CTGGTCCAAT CTCTACTATC 1080 AACCCGTCTC CTCCGTCTAA AGAATCTCAT AAATCTCCAA ACATGGCTAC ACCATTAGGC 1140 CCTGCCAGCT CCCTGCCCCA GAGCTTCCTG CTCAAGTGCT TAGAGCMGT GAGGAAGATC 1200 CAGGGCGATG GCGCAGCGCT CCAGGAGAAG CTGTGTGCCA CCTACAAGCT GTGCCACCCC 1260 GAGGAGCTGG TGCTGCTCGG ACACTCTCTG GGCATCCCCT GGGCTCCCCT GAGCTCCTGC 1320 CCCAGCCAGG CCCTGCAGCT GGCAGGCTGC TTGAGCCAAC TCCATAGCGG CCTTTTCCTC 1380 TACCAGGGGC TCCTGCAGGC CCTGGAAGGG ATATCCCCCG AGTTGGGTCC CACCTTGGAC 1440 ACACTGCAGC TGGACGTCGC CGACTTTGCC ACCACCATCT GGCAGCAGAT GGAAGAACTG 1500 GGAATGGCCC CTGCCCTGCA GCCCACCCAG GGTGCCATGC CGGCCTTCGC CTCTGCTTTC 1560 CAGCGCCGGG CAGGAGGGGT CCTGCTTGCT AGCCATCTGC AGAGCTTCCT GGAGGTGTCG 1620 TACCGCGTTC TACGCCACCT TGCGCAGCCC TGATAAGGAT CCGMTTCGG CAGC 1674 (2)序列編號NO: 314資料 ·· ⑴序列特性： (A) 長度：1470鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構·線形 (xi)序列描述：序列編號NO: 314 GCCGACGAGG AGCTGTGCGG TGGCCTCTGG CGGCTGGTCC TGGCACAGCG CTGGATGGAG 60 CGGCTCAAGA CTGTCGCTGG GTCCAAGATG CAAGGCTTGC TGGAGCGCGT GAACACGGAG 120 ATACACTTTG TCACCAAATG TGCCTTTCAG CCCCCCCCCA GCTGTCTTCG CTTCGTCCAG 180 ACCAACATCT CCCGCCTCCT GCAGGAGACC TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG 240 ATCACTCGCC AGAACTTCTC CCGGTGCCTG GAGCTGCAGT GTCAGCCCGA CTCCTCAACC 300 CTGGGCGGTG GGTCAGGAGG TGGGTCAGGA GGTGGATCCG GAGGTGGAAC CCAGGACTGC 360 TCCTTCCAAC ACAGCCCCAT CTCCTCCGAC TTCGCTGTCA AAATCCGTGA GCTGTCTGAC 420 TACCTGCTTC AAGATTACCC AGTCACCGTG GCCTCCAACC TGCAGTACGT AGAGGGCGGT 480 CGAGGCTCCC CGGGTGAACC GTCTGGTCCA ATCTCTACTA TCAACCCGTC TCCTCCGTCT 540 AAAGAATCTC ATAAATCTCC AAACATGGCT AACTGCTCTA TAATGATCGA TGAAATTATA 600 CATCACTTAA AGAGACCACC TAACCCTTTG CTGGACCCGA ACAACCTCAA TTCTGAAGAC 660 ATGGATATCC TGATGGAACG AAACCTTCGA ACTCCAAACC TGCTCGCATT CGTAAGGGCT 720 GTCAAGCACT TAGAAAATGC ATCAGGTATT GAGGCAATTC TTCGTAATCT CCAACCATGT 780 CTGCCCTCTG CCACGGCCGC ACCCTCTCGA CATCCAATCA TCATCAAGGC AGGTGACTGG 840 CAAGAATTCC GGGAAAAACT GACGTTCTAT CTGGTTACCC TTGAGCAAGC GCAGGAACAA 900 CAGTACGTAG AGGGCGGTGG AGGCTCCCCG GGTGAACCGT CTGGTCCAAT CTCTACTATC 960 AACCCGTCTC CTCCGTCTAA AGAATCTCAT AAATCTCCAA ACATGGCCGA CGAGGAGCTC 1020 TGCGGGGGCC TCTGGCGGCT GGTCCTGGCA CAGCGCTGGA TGGAGCGGCT CAAGACTGTC 1080 O:\92\92747.DOC -180- 200413407 GCTGGGTCCA AGATGCAAGG CTTGCTGGAG CGCGTGAACA CGGAGATACA CTTTGTCACC 1140 AAATGTGCCT TTCAGCCCCC CCCCAGCTGT CTTCGCTTCG TCCAGACCAA CATCTCCCGC 1200 CTCCTGCAGG AGACCTCCGA GCAGCTGGTG GCGCTGAAGC CCTGGATCAC TCGCCAGAAC 1260 TTCTCCCGGT GCCTGGAGCT GCAGTGTCAG CCCGACTCCT CAACCCTGGG CGGTGGGTCA 1320 GGAGGTGGGT CAGGAGGTGG ATCCGGAGGT GGCACCCAGG ACTGCTCCTT CCAACACAGC 1380 CCCATCTCCT CCGACTTCGC TGTCAAAATC CGTGAGCTGT CTGACTACCT GCTTCAAGAT 1440 TACCCAGTCA CCGTGGCCTC CAACCTGCAG 1470 (2)序列編號NO: 3 1 5資料； (i)序列特性· (A)長度：1194鹼基對 (B)形式：核酸 (C)股數：單 (D)拓撲結構 :線形 (xi)序列描述：序列編號NO: 315 GCTGATGAAG AACTGTGTGG TGGTCTGTGG CGGCTCGTCC TGGCACAGCG CTGGATGGAG 60 CGGCTCAAGA CTGTCGCTGG GTCCAAGATG CAAGGCTTGC TGGAGCGCGT GAACACGGAG 120 ATACACTTTG TCACCAAATG TGCCTTTCAG CCCCCCCCCA GCTGTCTTCG CTTCGTCCAG 180 ACCAACATCT CCCGCCTCCT GCAGGAGACC TCCGAGCAGC TGGTGGCGCT GAAGCCCTGG 240 ATCACTCGCC AGAACTTCTC CCGGTGCCTG GAGCTGCAGT GTCAGCCCGA CTCCTCAACC 300 CTGGGCGGTG GGTCAGGAGG TGGGTCAGGA GGTGGATCCG GAGGTGGCTC AGGGGGAGGT 360 AGTGGTACCC AGGACTGCTC CTTCCAACAC AGCCCCATCT CCTCCGACTT CGCTGTCAAA 420 ATCCGTGAGC TGTCTGACTA CCTGCTTCAA GATTACCCAG TCACCGTGGC CTCCAACCTG 480 CAGGAATTCA AGCITGAGCC CAGAGGGCCC ACAATCAAGC CCTGTCCTCC ATGCAAATGC 540 CCAGCACCTA ACCTCTTGGG TGGACCATCC GTCTTCATCT TCCCTCCAAA GATCAAGGAT 600 GTACTCATGA TCTCCCTGAG CCCCATAGTC ACATGTGTGG TGGTGGATGT GAGCGAGGAT 660 GACCCAGATG TCCAGATCAG CTGGTTTGTG AACAACGTGG AAGTACACAC AGCTCAGACA 720 CAAACCCATA GAGAGGATTA CAACAGTACT CTCCGGGCGG TCAGTGCCCT cCCCATCCAG 780 CACCAGGACT GGATGAGTGG CAAGGAGTTC AAATGCAAGG TCAACAACAA AGACCTCCCA 840 GCGCCCATCG AGAGAACCAT CTCAAAACCC AAAGGGTCAG TAAGAGCTCC ACAGGTATAT 900 GTCTTGCCTC CACCAGAAGA AGAGATGACT AAGAAACAGG TCACTCTGAC CTGCATGGTC 960 ACAGACTTCA TGCCTGAAGA CATTTACGTG GAGTGGACCA ACAACGGGAA AACAGAGCTA 1020 AACTACAAGA ACACTGAACC AGTCCTGGAC TCTGATGGn CTTACTTCAT GTACAGCAAG 1080 CTGAGAGTGG AAAAGAAGAA CTGGGTGGAA AGAAATAGCT ACTCCTGTTC AGTGGTCCAC 1140 GAGGGTCTGC ACAATCACCA CACGACTAAG AGCTTCTCCC GGACTCCGGG TAAA 1194 (2)序列編號NO: 316資料 • (i)序列特性： (A)長度：1131鹼基對 (B)形式：核酸 (C)股數：單

(D)拓撲結構：線形 O:\92\92747.DOC -181 200413407 (xi)序列描述：序列編號NO: 316 GCCACCCAGG ACTGCTCCTT TCAACACAGC CCCATCTCCT CCGACTTCGC TGTCAAAATC 60 CGTGAGCTGT CTGACTACCT GCTTCAAGAT TACCCAGTCA CCGTGGCCTC CAACCTGCAG 120 GACGAGGAGC TCTGCGGGGG CCTCTGGCGG CTGGTCCTGG CACAGCGCTG GATGGAGCGG 180 CTCAAGACTG TCGCTGGGTC CAAGATGCAA GGCTTGCTGG AGCGCGTGAA CACGGAGATA 240 CACTTTGTCA CCAAATGTGC CTTTCAGCCC CCCCCCAGCT GTCTTCGCTT CGTCCAGACC 300 AACATCTCCC GCCTCCTGCA GGAGACCTCC GAGCAGCTGG TGGCGCTGAA GCCCTGGATC 360 ACTCGCCAGA ACTTCTCCCG GTGCCTGGAG CTGCAGTGTC AGCCCGACTC CTCAACCCTG 420 GAATTCAAGC TTGAGCCCAG AGGGCCCACA ATCAAGCCCT GTCCTCCATG CAAATGCCCA 480 GCACCTAACC TCTTGGGTGG ACCATCCGTC TTCATCTTCC CTCCAAAGAT CAAGGATGTA 540 CTCATGATCT CCCTGAGCCC CATAGTCACA TGTGTGGTGG TGGATGTGAC CGAGGATGAC 600 CCAGATGTCC AGATCAGCTG GTTTGTGAAC AACGTGGAAG TACACACAGC TCAGACACAA 660 ACCCATAGAG AGGATTACAn CAGTACTCTC CGGGCGGTCA GTGCCCTCCC CATCCAGCAC 720 CAGGACTGGA TGAGTGGCAA GGAGTTCAAA TGCAAGGTCA ACAACAAAGA CCTCCCAGCG 780 CCCATCGAGA GAACCATCTC AAAACCCAAA GGGTCAGTAA GAGCTCCACA GGTATATGTC B40 TTGCCTCCAC CAGAAGAAGA GATGACTAAG AAACAGGTCA CTCTGACCTG CATGGTCACA 900 GACTTCATGC CTGAAGACAT TTACGTGGAG TGGACCAACA ACGGGAAAAC AGAGCTAAAC 960 TACAAGAACA CTGAACCAGT CCTGGACTCT GATOnTClT ACTTCATGTA CAGCAAGCTG 1020 AGAGTGGAAA AGAAGAACTG GGTGGAAAGA AATAGCTACT CCTGTTCAGT GGTCCACGAG 1080 GGTCTGCACA ATCACCACAC GACTAAGAGC TTCTCCCGGA CTCCGGGTAA A 1131 (2)序列編號NO: 317資料： (i)序列特性： (A) 長度：45鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號ΝΟ·_ 317 ACGTCCATGG CNTCNCCNGC NCCNCCTGCT TGTGCACTCC GAGTC 45 (2)序列編號NO: 318資料： (i)序列特性： (A) 長度：30鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 318 30

ATGCACGAAT TCCCTGACGC AGAGGGTGGA O:\92\92747.DOC -182- 200413407 (2)序列編號NO: 319資料： (i)序列特性： (A) 長度：33驗基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 319 TGACAAGCTT ACCTGACGCA GAGGGTGGAC CCT 33 (2)序列編號NO: 320資料： (i)序列特性： (A) 長度：10鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 320 AATTCGGCAA 1〇 (2)序列編號NO·· 321資料： (i)序列特性： (A) 長度：10鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 321 CATGTTGCCG 1〇 (2)序列編號NO: 322資料： (i)序列特性： O:\92\92747.DOC -183 200413407 (A) 長度：13驗基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 322 AATTCGGCGG CAA (2)序列編號NO: 323資料： (i)序列特性： (A) 長度· 13驗基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 323 CATGTTGCCG CCG (2)序列編號NO: 324資料： (i)序列特性： (A) 長度· 2 2驗基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構·線形 (xi)序列描述：序列編號NO: 324 AATTCGGCGG CAACGGCGGC AA (2)序列編號NO: 325資料： (i)序列特性： (A) 長度：22鹼基對 (B) 形式：核酸 13

13

22 O:\92\92747.DOC -184- 200413407 (c)股數：單 (D)拓撲結構：線形 (xi)序列描述：序列編號NO: 325 CATGTTGCCG CCGTTGCCGC CG 22 (2)序列編號NO: 326資料： (i)序列特性： (A) 長度：27鹼基對 (B) 形式：核酸 (C) 股數：單 _ (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 326 CGATCCATGG AGGTTCACCC TTTGCCT 27 (2)序列編號NO: 327資料： (i)序列特性： (A) 長度· 29驗基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 ® (xi)序列描述：序列編號NO: 327 GATCAAGCTT ATGGGCACTG GCTCAGTCT 29 (2)序列編號NO: 328資料： (i)序列特性： (A) 長度：27鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 O:\92\92747.DOC -185- 200413407 (xi)序列描述：序列編號NO: 328 CGATACATGT TGCCTACACC TGTCCTG 27 (2)序列編號NO: 329資料： (i)序列特性： (A) 長度：29鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 329 GATCAAGCTT AAGGGTGAAC CTCTGGGCA 29 (2)序列編號NO: 330資料： (i)序列特性： (A) 長度：27鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構·線形 (xi)序列描述：序列編號NO: 330 CGATCCATGG TCCTGCTGCC TGCTGTG 27 (2)序列編號NO: 331資料： (i)序列特性： (A) 長度：29鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 331 GATCAAGCTT AAGGTGTAGG CAAAGGGTG 29 O:\92\92747.DOC -186- 200413407 (2)序列編號NO: 332資料： (i)序列特性： (A) 長度：30驗基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 332 CGATCCATGG CTGTGGACTT TAGCTTGGGA 30 (2)序列編號NO: 333資料： (i)序列特性： (A) 長度：29鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 333 GATCAAGCTT AAGGCAGCAG GACAGGTGT 29 (2)序列編號NO: 334資料： (i)序列特性： (A) 長度：27鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 334 CGATCCATGG- ACTTTAGCTT GC5GAGAA 27 (2)序列編號NO: 335資料： (i)序列特性· O:\92\92747.DOC -187- 200413407 (A) 長度：29鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 335 GATCAAGCTT ACACAGCAGG CAGCAGGAC (2)序列編號NO: 336資料： (i)序列特性： (A) 長度：27鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 336 CGATCCATGG GAGAATGGAA AACCCAG (2)序列編號NO: 337資料： (i)序列特性： (A) 長度：29鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 337 GATCAAGCTT ACAAGCTAAA GTCCACAGC (2)序列編號NO: 338資料： (i)序列特性： (A) 長度：27鹼基對 (B) 形式：核酸 29

27 29

O:\92\92747.DOC -188- 27 200413407 (c)股數：單 (D)拓撲結構：線形 (xi)序列描述：序列編號NO: 338

CGATCCATGG GACCCACTTG CCTCTCA (2)序列編號NO: 339資料： (i)序列特性： (A) 長度：29鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 339

GATCAAGCTT ACAGTTGTCC CCGTGCTGC (2)序列編號NO: 340資料： (i)序列特性： (A) 長度：27鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形

(xi)序列描述：序列編號NO: 340 CAGTCCATGG GAACCCAGCT TCCTCCA (2)序列編號NO: 341資料： (i)序列特性： (A) 長度：29鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 29 27

O:\92\92747.DOC -189- 200413407 (xi)序列描述：序列編號NO: 341 GATCAAGCTT AAAGGAGGCT CTGCAGGGC 29 (2)序列編號NO: 342資料： (i)序列特性： (A) 長度：27鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 342 CGATCCATGG GCAGGACCAC AGCTCAC 27 (2)序列編號NO: 343資料： (i)序列特性： (A) 長度· 30驗基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 343 GATCAAGCTT ACTGTGGAGG AAGCTGGGTT 30 (2)序列編號NO: 344資料： (i)序列特性： (A) 長度：30鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 344 CGATCCATGG CTCACAAGGA TCCCAATGCC 30 O:\92\92747.DOC -190- 200413407 (2)序列編號NO: 345資料： (i)序列特性： (A) 長度：29鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 345 GATCAAGCTT ATGTGGTCCT GCCCTGTGG 29 (2)序列編號NO: 346資料： (i)序列特性： (A) 長度：30鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 346 CGATCCATGG ATCCCAATGC CATCTTCCTG 30 (2)序列編號NO: 347資料： (i)序列特性： (A) 長度：29鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 347 GSYysSHVYY ACTTGTGAGC TGTGGTCCT 29 (2)序列編號NO: 348資料： (i)序列特性： O:\92\92747.DOC -191- 200413407 (A) 長度：30鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 348 CGATCCATGG CCATCTTCCT GAGCTTCCAA 30 (2)序列編號NO: 349資料： (i)序列特性：

(A) 長度：32鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 349 GATCAAGCTT AATTGGGATC CTTGTGAGCT GT 32 (2)序列編號NO: 350資料： (i)序列特性： (A) 長度：83鹼基對

(B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 350 AATTCCGTCG TAAACTGACC TTCTATCTGA AAACCTTGGA GAACGCGCAG GCTCAACAGT 60 ACGTAGAGGG CGGTGGAGGC TCC 83 (2)序列編號NO: 351資料： (i)序列特性： (A) 長度：83鹼基對 (B) 形式：核酸 O:\92\92747.DOC -192- 200413407 (c)股數：單 (D)拓撲結構：線形 (xi)序列描述：序列編號NO: 351 83

CCGGGGAGCC TCCACCGCCC TCTACGTACT GTTGAGCCTG CGCGTTCTCC AAGGTTTTCA 60 FATAGAAGGT CAGTTTACGA CGG (2)序列編號NO: 352資料： (i)序列特性： (A) 長度：59鹼基對 (B) 形式：核酸

(C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 352 GTTACCCTTG AGCAAGCGCA GGAACAACAG GGTGGTGGCT CTAACTGCTC TATAATGAT 59 (2)序列編號NO: 353資料： (i)序列特性·· (A) 長度· 5 6驗基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 353 CGATCATTAT AGAGCAGTTA GAGCCACCAC CCTGnGTTC CTGCGCTTGC TCAAGG 56 (2)序列編號NO: 354資料： (i)序列特性： (A) 長度：83鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 O:\92\92747.DOC -193- 200413407 (xi)序列描述：序列編號NO: 354

GmCCCTTG AGCAAGCGCA GGAACAACAG GGTGGTGGCT CTGGCGGTGG CAGCGGCGGC 60 GCTTCTMCT GCTCTATAAT GAT 83 (2)序列編號NO: 355資料： (i)序列特性： (A) 長度：80鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形

(xi)序列描述：序列編號NO: 355 CGATCAmT agagcag™ gaaccgccgc CGCTGCCACC GCCAGAGCCA CCACCCTGTT 60 GTTCCTGCGC TTGCTCAAGG 80 (2)序列編號NO: 356資料： (i)序列特性： (A) 長度：32鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形

(xi)序列描述：序列編號NO: 356 GATCGACCAT GGCTCTGGAC CCGAACAACC TC 32 (2)序列編號NO: 357資料： (i)序列特性： (A) 長度：28鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 357 O:\92\92747.DOC -194- 200413407 CTCGATTACG TACAAAGGTG CAGGTGGT 28 (2)序列編號NO: 358資料： (i)序列特性： (A) 長度：32鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 358 GATCGACCAT GGCTAATGCA TCAGGTATTG AG 32 (2)序列編號NO: 359資料： (i)序列特性： (A) 長度：28驗基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 359 CTCGATTACG TATTCTAAGT TCTTGACA 28 (2)序列編號NO: 360資料： (i)序列特性： (A) 長度：32驗基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 360 GATCGACCAT GGCTGCACCC TCTCGACATC CA 32 (2)序列編號NO: 361資料： O:\92\92747.DOC -195- 200413407 (i)序列特性： (A) 長度：28鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 361 CTCGATTACG TAGGCCGTGG CAGAGGGC 28 (2)序列編號NO: 362資料： (i)序列特性： (A) 長度：32驗基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO.· 362 GATCGACCAT GGCTGCAGGT GACTGGCAAG AA 32 (2)序列編號NO: 363資料： (i)序列特性： (A) 長度：28鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 363 CTCGATTACG TACTTGATGA TGATTGGA 28 (2)序列編號NO: 364資料： (i)序列特性： (A)長度：54鹼基對 O:\92\92747.DOC -196- 200413407 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 364 TGGCGTAGAA CGCG 54

GCTCTGAGAG CCGCCAGAGC CGCCAGAGGG CTGCGCAAGG (2)序列編號NO: 365資料： (i)序列特性： (A) 長度：54鹼基對

(B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 TCAAGTCTTT AGAG 54

(xi)序列描述：序列編號NO: 365 CAGCCCTCTG GCGGCTCTGG CGGCTCTCAG AGCTTCCTGC (2)序列編號NO: 366資料： (i)序列特性： (A) 長度：18鹼基對

(B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形

(xi)序列描述：序列編號NO: 366 GGGCTGCGCA AGGTGGCG (2)序列編號NO: 367資料： (〇序列特性： (A) 長度：21驗基對 (B) 形式：核酸 (C) 股數：單 O:\92\92747.DOC -197 200413407 (D)拓撲結構：線形 (xi)序列描述：序列編號NO: 367 ACACCATTGG GCCCTGCCAG C 21 (2)序列編號NO: 368資料： (i)序列特性： (A) 長度：32鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 368 GATCGACCAT GGCTTACAAG CTGTGCCACC CC 32 (2)序列編號NO: 369資料： (i)序列特性： (A) 長度：36驗基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 369 CGATCGAAGC TTATTAGGTG GCACACAGCT TCTCCT 36 (2)序列編號NO: 370資料： (i)序列特性： (A) 長度：32鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 370 O:\92\92747.DOC -198- 200413407

GATCGACCAT GGCTCCCGAG HGGGTCCCA CC (2)序列編號NO: 371資料： (i)序列特性： (A) 長度：36鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形

(xi)序列描述：序列編號NO: 371 CGATCGAAGC TTATTAGGAT ATCCCTTCCA GGGCCT (2)序列編號NO: 372資料： (i)序列特性： (A) 長度：32鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形

(xi)序列描述：序列編號NO: 372 GATCGACCAT GGCTATGGCC CCTGCCCTGC AG (2)序列編號NO: 373資料： (i)序列特性： (A) 長度：36鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 373

CGATCGAAGC TTAmTCCC AGTTCTTCCA TCTGCT (2)序列編號NO: 374資料： O:\92\92747.DOC -199- 200413407 (i)序列特性： (A) 長度：32鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 374

GATCGACCAT GGCTACCCAG GGTGCCATGC CG (2)序列編號NO: 375資料： (i)序列特性： (A) 長度· 3 6驗基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 375

CGATCGAAGC TTAmGGGC TGCAGGGCAG GGGCCA (2)序列編號NO: 376資料： (i)序列特性： (A) 長度：32鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形

(xi)序列描述：序列編號NO: 376 GATCGACCAT GGCTTCTGCT TTCCAGCGCC GG (2)序列編號NO: 377資料： (i)序列特性： (A)長度：36驗基對 O:\92\92747.DOC -200- 200413407 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 377

CGATCGAAGC TTAmGGCG AAGGCCGGCA TGGCAC (2)序列編號NO: 378資料： (i)序列特性： (A) 長度：21鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形

(xi)序列描述：序列編號NO: 378 GTAGAGGGCG GTGGAGGCTC C (2)序列編號NO: 379資料： (i)序列特性： (A) 長度：25鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形

(xi)序列描述：序列編號NO: 379 CCGGGGAGCC TCCACCGCCC TCTAC (2)序列編號NO·· 380資料： (i)序列特性： (A) 長度：53鹼基對 (B) 形式：核酸 (C) 股數：單 O:\92\92747.DOC -201- 200413407 (D)拓撲結構：線形 (xi)序列描述：序列編號NO: 380 TTCTACGCCA CCTTGCGCAG CCCGGCGGCG GCTCTGACAT GTCTACACCA TTG 53 (2)序列編號NO: 381資料： (i)序列特性： (A) 長度：53鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 _ (xi)序列描述：序列編號NO: 381 CAATGGTGTA GACATGTCAG AGCCGCCGCC GGGCTGCGCA AGGTGGCGTA GAA 53 (2)序列編號NO·· 382資料： (i)序列特性： (A) 長度：37鹼基對 (B) 形式：核酸 (C) 股數：單

(D) 拓撲結構.線形 I (xi)序列描述··序列編號NO: 382 零 GTCAGACCAT GGCCGATTAC CCAGTCACCG TGGCCTC 37 (2)序列編號NO: 383資料： (i)序列特性： (A) 長度：37鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 383 O:\92\92747.DOC -202- 200413407 GTCAGCCCAT GGCCGCCTCC AACCTGCAGG ACGAGGA 37 (2)序列編號NO: 384資料： (i)序列特性： (A) 長度：38鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO·. 384 GTCAGACCAT GGCCGTCGCT GGGTCCAAGA TGCAAGGC 38 (2)序列編號NO: 385資料： (i)序列特性： (A) 長度·· 38鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 385 GTCAGACCAT GGCCCGCTTC GTCCAGACCA ACATCTCC 38 (2)序列編號NO·· 386資料： (i)序列特性： (A) 長度：38鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 386 GTCAGACCAT GGCCACCAAC ATCTCCCGCC TCCTGCAG 38 (2)序列編號NO: 387資料： O:\92\92747.DOC -203- 200413407 (i)序列特性： (A) 長度：39鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 387 TCTGACAAGC TTAnGAAGC AGGTAGTCAG ACAGCTCAC 39 (2)序列編號NO: 388資料： ⑴序列特性：籲 (A) 長度：38鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 388 TCTGACAAGC TTACACGGTG ACTGGGTAAT CTTGAAGC 38 (2)序列編號NO: 389資料： (i)序列特性： (A) 長度：37鹼基對 _ (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 389 TCTGACAAGC HAAGTCTTG AGCCGCTCCA TCCAGCG 37 (2)序列編號NO: 390資料： (i)序列特性： (A)長度：32鹼基對 O:\92\92747.DOC 204- 200413407 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 390 GTCAAGAAGC TTACGGCTGA AAGGCACATT TG 32 (2)序列編號NO: 391資料： (i)序列特性： (A) 長度：36鹼基對 (B) 形式：核酸籲 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 391 TCTGACAAGC TTAAAGACAG CTGGGGCSGGG GCTGAA 36 (2)序列編號NO: 392資料： (i)序列特性： (A) 長度：37鹼基對 (B) 形式：核酸 (C) 股數：單 — (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 392 CTCGACAAGC TTACTGGACG AAGCGAAGAC AGCTGGG 37 (2)序列編號NO: 393資料： (i)序列特性： (A) 長度：57鹼基對 (B) 形式：核酸 (C) 股數：單 O:\92\92747.DOC -205- 200413407 (D)拓撲結構：線形 (xi)序列描述：序列編號NO: 393

GCGGCTG

GTTC5CCATGG CNTCNAAYCT GCARGAYGAR GARCTGTGCG GOjGCCTCTG (2)序列編號NO: 394資料： (i)序列特性： (A) 長度：57鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形

GCTGGGTC

(xi)序列描述：序列編號NO: 394 GTTGCCATGG CNAAYCTGCA RGAYGARGAR CTGTGYGGGG GCCTCTGGCG (2)序列編號NO: 395資料： (i)序列特性： (A) 長度：57鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形

GGTCCTG

(xi)序列描述：序列編號NO: 395 GTTGCCATGG CNCTGCARGA YGARGARCTG TGYGGYGGCC TCTGGCGGCT (2)序列編號NO: 396資料： (i)序列特性： (A) 長度：57鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 396 O:\92\92747.DOC -206- 200413407 GTTGCCATGG CNCARGAYGA RGARCTGTGY GGYGGYCTCT GGCGGCTGGT CCTGGCA 57 (2)序列編號NO: 397資料： (i)序列特性： (A) 長度：57鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 397 GTTGCCATGG CNGAYGARGA RCTGTGYGGY GGYCTCTGGC GGCTGGTCCT GGCACAG 57 (2)序列編號NO: 398資料： (i)序列特性： (A) 長度：57鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 398 GTTGCCATGG CNGARGARCT GTGYGGYGGY CTCTGGCGGC TGGTCCTGGC ACAGCGC 57 (2)序列編號NO: 399資料： (i)序列特性： (A) 長度：57驗基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 399 GTTGCCATGG CNGARCTGTG YGGYGGYCTG TGGCGYCTGG TCCTGGCACA GCGCTGG 57 (2)序列編號NOMOO資料： O:\92\92747.DOC -207- 200413407 (i)序列特性： (A) 長度：57鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形

(xi)序列描述：序列編號NO: 400 GTTGCCATGG CNCTGTGYGG YGGYCTGTGG CGYCTGGTCC (2)序列編號NO: 401資料： (i)序列特性： (A) 長度：42鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 401

GTTGCCATGG CWGATGAAGA ACTGTGTGGN GGNCTGTGGC (2)序列編號NO: 402資料： (i)序列特性： (A) 長度：30鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形

(xi)序列描述：序列編號NO: 402 TATGCAAGCT TAGGCCACGG TGACTGGGTA (2)序列編號NO: 403資料： (i)序列特性： (A)長度· 30驗基對 TGGCACAGCG CTGGATG 57

O:\92\92747.DOC -208 200413407 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 403 TATGCAAGCT TAGGAGGCCA CGGTGACTGG^ (2)序列編號NO: 404資料： (i)序列特性： (A) 長度：30鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構·線形

(xi)序列描述：序列編號NO: 404 TATGCAAGCT TAGTTGGAGG CCACGGTGAC (2)序列編號NO: 405資料： (i)序列特性： (A) 長度：30鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 405

TATGCAAGCT TACAGGTTGG AGGCCACGGT (2)序列編號NO: 406資料： (i)序列特性： (A) 長度·· 30鹼基對 (B) 形式：核酸 (C) 股數：單 30 30

O:\92\92747.DOC .209- 200413407 (D)拓撲結構：線形 (xi)序列描述：序列編號NO: 406 TATGCAAGCT TAGTCCAGGT TGGAGGCCAC 30 (2)序列編號NO: 407資料： (i)序列特性： (A) 長度：30鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 407 TATGCAAGCT TACTCGTCCA GGTTGGAGGC 30 (2)序列編號NO: 408資料： (i)序列特性： (A) 長度：30鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 408 TATGCAAGCT TACTCCTCGT CCAGGTTGGA 30 (2)序列編號NO: 409資料： (i)序列特性： (A) 長度· 44驗基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 409 O:\92\92747.DOC -210- 200413407

GACTAGCCAT GGCNGAYGAR GARCTGTGYG GTGGCCTCTG (2)序列編號NO: 410資料： (i)序列特性： (A) 長度：32鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形

(xi)序列描述：序列編號NO: 410 GACTAGTACG TACTGCAGT TGGAGGCCAC GG (2)序列編號NO: 411資料： (i)序列特性： (A) 長度：36鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 411

GCAGGTTACG TATTGAAGCA GGTAGTCAGA CAGCTC (2)序列編號NO: 412資料： (i)序列特性： (A) 長度：36鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 412 GCAGGTTACG TACACGGTGA CTGGGTAATC πϋΑΑσ (2)序列編號NO: 413資料： GCGC 44

O:\92\92747.DOC -211- 200413407 (i)序列特性： (A) 長度：35鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 413

GCAGGTTACG TAAGTCTTGA GCCGCTCCAT CCAGC (2)序列編號NO: 414資料： (i)序列特性： (A) 長度· 36驗基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形

(xi)序列描述：序列編號NO: 414 GCAGGTTACG TAGCCAGCGA CAGTCTTGAG CCGCTC (2)序列編號NO: 415資料： (i)序列特性： (A) 長度：49鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO·. 415

GTCAAGCCAT GGCNCCRCCR AGCTGTCTRC GCTTCGTTCA (2)序列編號NO: 416資料： (i)序列特性： (A)長度：38鹼基對 GACCAACTC 49

O:\92\92747.DOC -212- 200413407 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NOM16 GCAGGmCG TACGGCTGAA AGGCACATTT GGTGACAA (2)序列編號NO: 417資料： (i)序列特性： (A) 長度· 30驗基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 417 GCAGGTTACG TAAAGACAGC TGGGGGGGGG (2)序列編號NO: 418資料： (i)序列特性： (A) 長度：34鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 418 GCAGGTTACG TACTGGACGA AGCGAAGACA GCTG (2)序列編號NO: 419資料： (i)序列特性： (A) 長度：29鹼基對 (B) 形式：核酸 (C) 股數：單 38

30

34 O:\92\92747.DOC -213- 200413407 (D)拓撲結構：線形 (xi)序列描述：序列編號NO: 419 TATGCTACGT AGGCCACGGT GACTGGGTA 29 (2)序列編號NO: 420資料： (i)序列特性： (A) 長度· 2 9驗基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 420 TATGCTACGT AGGAGGCCAC GGTGACTGG 29 (2)序列編號NO: 421資料： (i)序列特性： (A) 長度：29鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 421 TATGCTACGT AGTTGGAGGC CACGGTGAC 29 (2)序列編號NO: 422資料： (i)序列特性： (A) 長度：29鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 422 O:\92\92747.DOC -214- 200413407 TATGCTACGT ACAGCTTGGA GGCCACGGT 29 (2)序列編號NO: 423資料： (i)序列特性： (A) 長度：29鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 423 TATGCTACGT AGTCCAGGTT GGAGGCCAC 29 (2)序列編號NO: 424資料： (i)序列特性： (A) 長度：29鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO·. 424 TATGCTACGT ACTCGTCCAG GTTGGAGGC 29 (2)序列編號NO: 425資料：春 (i)序列特性： (A) 長度：29鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 425 TATGCTACGT ACTCCTCGTC CAGGTTGGA 29 (2)序列編號NO: 426資料： O:\92\92747.DOC -215- 200413407 (i)序列特性： (A) 長度：46鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NOM26 TCAGTTGGAT CCGGCGGCGG AAGCGGAGGT GGCTCTGGGG GAGGTA 46 (2)序列編號NO: 427資料： ⑴序列特性：籲 (A) 長度：48鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 427 TCAGTTGGAT CCTCCGCCAG AACCACCGCC TGACCCACCT CCTGACCC 48 (2)序列編號NO: 428資料： (i)序列特性： (A) 長度·· 60鹼基冑 · (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 428 GTCTGAGGCG CCACCGCACC GACCGCTGGA CAACCGCCTC TGACCCAGGA CTGCTCCTTC 60 (2)序列編號NO: 429資料： (i)序列特性： (A)長度：46鹼基對 O:\92\92747.DOC -216 200413407 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO.· 429 GTCTGAGGCG CCACCGCACC GACCACCCAG GACTGCTCCT TCCAAC 46 (2)序列編號NO·. 430資料： (i)序列特性： (A) 長度：60鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 430 GTCTGAGGCG CCGAGTGGAC GCGGGCTCCA CGGTGGCGGC AGGGTTGAGG AGTCGGGCTG 60 (2)序列編號NO: 431資料： (i)序列特性： (A) 長度：57鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO·. 431 GTTGCCATGG CNTCNAAYCT GCARGAYGAR GARCTGTGCG GGGGCCTCTG GCGGCTG 57 (2)序列編號NO: 432資料： (i)序列特性： (A) 長度：57鹼基對 (B) 形式：核酸 (C) 股數：單 O:\92\92747.DOC -217- 200413407 (D)拓撲結構：線形 (xi)序列描述：序列編號NO: 432

GCTGGTC

GTTGCCATGG CNAAYCTGCA RGAYGARGAR CTGTGYGGGG GCCTCTGGCG (2)序列編號NO: 433資料： (i)序列特性： (A) 長度：57鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形

GGTCCTG

(xi)序列描述：序列編號NO: 433 GTTGCCATGG CNCTGCARGA YGARGARCTG TGYGGYGGCC TCTGGCGGCT (2)序列編號NO: 434資料： (i)序列特性： (A) 長度：57驗基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形

CCTGGCA

(xi)序列描述：序列編號NO: 434 GTTGCCATGG CNCARGAYGA RGARCTGTGY GGYGGYCTCT GGCGGCTGGT (2)序列編號NO: 435資料： (i)序列特性： (A) 長度：57鹼基對 (B) 形式··核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 435 O:\92\92747.DOC -218- 200413407 GTTGCCATGG CNGAYGARGA RCTGTGYGGY GGYCTCTGGC GGCTGGTCCT GGCACAG 57 (2)序列編號NO: 436資料： (i)序列特性： (A) 長度：57鹼基對 (B) 形式··核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 436 GTTGCCATGG CNGARGARCT GTGYGGYGGY CTCTGGCGGC TGGTCCTGGC ACAGCGC 57 (2)序列編號NOM37資料： (i)序列特性： (A) 長度：57鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 437 GTTGCCATGG CNGARCTGTG YGGYGGYCTG TGGCGYCTGG TCCTGGCACA GCGCTGG 57 (2)序列編號NO·· 438資料： (i)序列特性： (A) 長度：57鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 438 GTTGCCATGG CNCTGTGYGG YGGYCTGTGG CGYCTGGTCC TGGCACAGCG CTGGATG 57 (2)序列編號NO: 439資料： O:\92\92747.DOC -219- 200413407 (i)序列特性： (A) 長度：30鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 439 TATGCAAGCT TAGGCCACGG TGACTGGGTA 30 (2)序列編號NO: 440資料： (i)序列特性： _ (A) 長度：30鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 440 TATGCAAGCT TAGGAGC5CCA CGGTGACTGG 30 (2)序列編號NO: 441資料： (i)序列特性： (A) 長度· 30驗基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 441 TATGCAAGCT TAGTTGGAGG CCACGGTGAC 30 (2)序列編號NO·· 442資料： (i)序列特性： (A)長度：30鹼基對 O:\92\92747.DOC -220- 200413407 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 442 TATGCAAGCT TACAOJrTGG AGGCCACGGT (2)序列編號NO: 443資料： (i)序列特性： (A) 長度：30鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 443 TATGCAAGCT TACTGCAGGT TGGAGGCCAC (2)序列編號NO: 444資料： (i)序列特性： (A) 長度：30鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 444 TATGCAAGCT TAGTCCTGCA GGTTGGAGGC (2)序列編號NO·· 445資料： (i)序列特性： (A) 長度：30鹼基對 (B) 形式：核酸 (C) 股數：單 30

30

30 O:\92\92747.DOC -221- 200413407 (D)拓撲結構：線形， (xi)序列描述：序列編號NO: 445

TATGCAAGCT TACTCGTCCT GCAGGTTGGA (2)序列編號NO·· 446資料： (i)序列特性·· (A) 長度：30鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形

(xi)序列描述：序列編號NO: 446 TATGCAAGCT TACTCCTCGT CCTGCAGGTT (2)序列編號NO: 447資料： (i)序列特性： (A) 長度：47鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 447

GCTACGTCTA GATCTCCTGA CCTCGACCCA GGACTGCTCC (2)序列編號NO·· 448資料： (i)序列特性： (A) 長度：68鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 448 TTCCAAC 47

O:\92\92747.DOC -222- 200413407 GCTAGTTCTA GACCATCCTG GCTGACACGG TGAAACACCG TCTCTACGGG CTGACACTGC 60 AGCTCCAG 68 (2)序列編號NO·· 449資料： (i)序列特性： (A) 長度：56驗基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 449 GTCAGTACTA GTATGGGTGT CCGGGCTCTT CGGCTCCTGC AGGTTGGAGG CCACGG 56 · (2)序列編號NO: 450資料： (i)序列特性： (A) 長度· 4 5驗基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 450

GTCAGTACTA GTCCGCCATC TCCGACACCA TTAGGCCCTG CCAGC (2)序列編號NO: 451資料： (i)序列特性： (A) 長度：49鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO·. 451

GTCAGTTCCG GAGATTTCGG nCTGCAGAG GGCTGCGCAA GGTGGCGTA (2)序列編號ΝΟ·_ 452資料： O:\92\92747.DOC -223- 200413407 (i)序列特性： (A) 長度：64鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO·. 452 GTCAGTTCCG GATACTCATA CCAGCCCGCC ATCCCCGGGT TCTAATCTGC AAGATGAAGA 60 GCTG 64

(2)序列編號NO: 453資料： (i)序列特性： (A) 長度：61鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 453 GTCAGTACTA GTATGGGTGT CCGGGCTCIT CGGAAAGGCA CATTTGGTGA CAAAGTGTAT 60 C 61 (2)序列編號NO: 454資料：

(i)序列特性： (A) 長度：48鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO·. 454 GTCAGTACTA GTCCGCCATC TCCGGGTACA CCATTAGGCC CTGCCAGC 48 (2)序列編號NO·· 455資料： (i)序列特性： O:\92\92747.DOC -224- 200413407 (A) 長度：63驗基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 455

AGCCCCCCCC

GTCAGTTCCG GATACTCATA CCAGCCCGCC ATCCCCGGGT MGCTCTTTC

CAG (2)序列編號NO: 456資料： (i)序列特性： (A) 長度：33驗基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 456

GTCAGACCAT GGCCACTCAG GACTCCTCTT TTC (2)序列編號NO: 457資料： (i)序列特性： (A) 長度：27驗基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形

(xi)序列描述：序列編號NO: 457 CACTTTGTCA CCAAATCTGC CTTTCAG (2)序列編號NO: 458資料： (i)序列特性： (A) 長度：27鹼基對 (B) 形式：核酸 O:\92\92747.DOC -225- 200413407 (c)股數：單 (D)拓撲結構：線形 (xi)序列描述：序列編號NO: 458

CTGAAAGGCA GATTTGGTGA CAAAGTG (2)序列編號NO: 459資料： (i)序列特性： (A) 長度：21鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形

(xi)序列描述：序列編號NO: 459 GCCCCCCCCC AGCTCTCTTC G (2)序列編號NO: 460資料： (i)序列特性： (A) 長度· 21驗基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形

(xi)序列描述：序列編號NO: 460 CGAAGAGAGC TGGGGGGCJGG C (2)序列編號NO: 461資料： (i)序列特性： (A) 長度：41驗基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 O:\92\92747.DOC -226 200413407 (xi)序列描述：序列編號NO: 461 GTCAGTTACG TACAGGGTTG AAGGAGTCGG GCTGAGACTG C 41 (2)序列編號NO·· 462資料： (i)序列特性： (A) 長度：30鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 462 GTCAGTCCAT GGCTACTCAA GGTGCTATGC 30 (2)序列編號NO: 463資料： (i)序列特性· (A) 長度· 3 1驗基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 463 GTAGCATACG TAGGGCTGCA GGGCAGGGGC C 31 (2)序列編號NO: 464資料： (i) 序列特性： (A) 長度：166胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 464 O:\92\92747.DOC -227- 200413407

Ala Pro Pro Arg Leu lie Cys Asp Ser Arg Val Leu Glu Arg Tyr Leu 15 10 15

Leu Glu Ala Lys Glu Ala Glu Asn lie Thr Thr Gly Cys Ala Glu His 20 25 30

Cys Ser Leu Asn Glu Asn lie Thr Val Pro Asp Thr Lys Val Asn Phe 35 40 45

Tyr Ala Trp Lys Arg Met Glu Val Gly Gin Gin Ala Val Glu Val Trp 50 55 60

Gin Gly Leu Ala Leu Leu Ser Glu Ala Val Leu Arg Gly Gin Ala Leu 65 70 75 80

Leu Val Asn Ser Ser Gin Pro Trp Glu Pro Leu Gin Leu His Val Asp 85 90 95

Lys Ala Val Ser Gly Leu Arg Ser Leu Thr Thr Leu Leu Arg Ala Leu 100 105 110

Gly Ala Gin Lys Glu Ala lie Ser Pro Pro Asp Ala Ala Ser Ala Ala 115 120 125

Pro Leu Arg Thr lie Thr Ala Asp Thr Phe Arg Lys Leu Phe Arg Val 130 135 140

Tyr Ser Asn Phe Leu Arg Gly Lys Leu Lys Leu Tyr Thr Gly Glu Ala

145 150 155 160

Cys Arg Thr Gly Asp Arg 165 (2)序列編號NO: 465資料： (i) 序列特性： (A) 長度：165胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無

(xi)序列描述：序列編號NO: 465

Glu Gly lie Cys Arg Asn Arg Val Thr Asn Asn Val Lys Asp Val Thr 15 10 15

Lys Leu Val Ala Asn Leu Pro Lys Asp Tyr Met lie Thr Leu Lys Tyr 20 25 30

Val Pro Gly Met Asp Val Leu Pro Ser His Cys Trp He Ser Glu Met 35 40 45

Val Val Gin Leu Ser Asp Ser Leu Thr Asp Leu Leu Asp Lys Phe Ser 50 55 60

Asn lie Ser Glu Gly Leu Ser Asn Tyr Ser He He Asp Lys Leu Val 65 70 75 80

Asn lie Val Asp Asp Leu Val Glu Cys Val Lys Glu Asn Ser Ser Lys 85 90 95

Asp Leu Lys Lys Ser Phe Lys Ser Pro Glu Pro Arg Leu Phe Thr Pro 100 105 110

Glu Glu Phe Phe Arg lie Phe Asn Arg Ser lie Asp Ala Phe Lys Asp 115 120 125

Phe Val Val Ala Ser Glu Thr Ser Asp Cys Val Val Ser Ser Thr Leu 130 135 140

Ser Pro Glu Lys Asp Ser Arg Val Ser Val Thr Lys Pro Phe Met Leu 145 150 155 160

Pro Pro Val Ala Ala O:\92\92747.DOC -228- 165 200413407 (2)序列編號NO: 466資料： (i) 序列特性： (A) 長度：139胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 466

Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala 15 10 15

Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val 20 25 30

Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp 35 40 45

Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala 50 55 60

Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie His 65 70 75 80

Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe 85 90 95

Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu 100 105 110

Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys Leu 115 120 125

Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu 130 135

(2)序列編號NO: 467資料： (i) 序列特性： (A) 長度：155胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 467

Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser Lys Leu Leu 15 10 15

Arg Asp Ser His Val Leu His Ser Arg Leu Ser Gin Cys Pro Glu Val 20 25 30 O:\92\92747.DOC -229- 200413407

His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala Val Asp Phe Ser Leu 35 40 45

Gly Glu Trp Lys Thr Gin Met Glu Glu Thr Lys Ala Gin Asp lie Leu 50 55 60

Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala Ala Arg Gly Gin 65 70 75 80

Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gin Leu Ser Gly Gin 85 90 95

Val Arg Leu Leu Leu Gly Ala Leu Gin Ser Leu Leu Gly Thr Gin Leu 100 105 110

Pro Pro Gin Gly Arg Thr Thr Ala His Lys Asp Pro Asn Ala He Phe 115 120 125

Leu Ser Phe Gin His Leu Leu Arg Gly Lys Val Arg Phe Leu Met Leu 130 135 140

Val Gly Gly Ser Thr Leu Cys Val Arg Glu Phe 145 150 155 (2)序列編號NO: 468資料：

(i) 序列特性： (A) 長度：309胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NOM68

Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser Lys Leu Leu 15 10 15

Arg Asp Ser His Val Leu His Ser Arg Leu Ser Gin Cys Pro Glu Val 20 25 30

His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala Val Asp Phe Ser Leu 35 40 45

Gly Glu Trp Lys Thr Gin Met Glu Glu Thr Lys Ala Gin Asp He Leu 50 55 60

Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala Ala Arg Gly Gin 65 70 75 80

Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gin Leu Ser Gly Gin 85 90 95

Val Arg Leu Leu Leu Gly Ala Leu Gin Ser Leu Leu Gly Thr Gin Leu 100 105 110

Pro Pro Gin Gly Arg Thr Thr Ala His Lys Asp Pro Asn Ala lie Phe 115 120 125

Leu Ser Phe Gin His Leu Leu Arg Gly Lys Val Arg Phe Leu Met Leu 130 135 140

Val Gly Gly Ser Thr Leu Cys Val Arg Glu Phe Gly Gly Asn Met Ala 145 150 155 160

Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser Lys Leu Leu 165 170 175

Arg Asp Ser His Val Leu His Ser Arg Leu Ser Gin Cys Pro Glu Val 180 185 190

His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala Val Asp Phe Ser Leu 195 200 205 O:\92\92747.DOC -230- 200413407

Gly Glu Trp Lys Thr Gin Met Glu Glu Thr Lys Ala Gin Asp He Leu 210 215 220

Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala Ala Arg Gly Gin 225 230 235 240

Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gin Leu Ser Gly Gin 245 250 255

Val Arg Leu Leu Leu Gly Ala Leu Gin Ser Leu Leu Gly Thr Gin Gly 260 265 270

Arg Thr Thr Ala His Lys Asp Pro Asn Ala lie Phe Leu Ser Phe Gin 275 280 285

His Leu Leu Arg Gly Lys Val Arg Phe Leu Met Leu Val Gly Gly Ser 290 295 300

Thr Leu Cys Val Arg 305 (2)序列編號NO: 469資料： (i) 序列特性：

(A) 長度：312胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 469

Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser Lys Leu Leu 15 10 15

Arg Asp Ser His Val Leu His Ser Arg Leu Ser Gin Cys Pro Glu Val 20 25 30

His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala Val Asp Phe Ser Leu 35 40 45

Gly Glu Trp Lys Thr Gin Met Glu Glu Thr Lys Ala Gin Asp lie Leu 50 55 60

Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala Ala Arg Gly Gin 65 70 75 80

Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gin Leu Ser Gly Gin 85 90 95

Val Arg Leu Leu Leu Gly Ala Leu Gin Ser Leu Leu Gly Thr Gin Leu 100 105 110

Pro Pro Gin Gly Arg Thr Thr Ala His Lys Asp Pro Asn Ala lie Phe 115 120 125

Leu Ser Phe Gin His Leu Leu Arg Gly Lys Val Arg Phe Leu Met Leu 130 135 140

Val Gly Gly Ser Thr Leu Cys Val Arg Glu Phe Gly Asn Met Ala Ser 145 150 155 160

Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser Lys Leu Leu Arg 165 170 175

Asp Ser His Val Leu His Ser Arg Leu Ser Gin Cys Pro Glu Val His 180 185 190

Pro Leu Pro Thr Pro Val Leu Leu Pro Ala Val Asp Phe Ser Leu Gly 195 200 205

Glu Trp Lys Thr Gin Met Glu Glu Thr Lys Ala Gin Asp lie Leu Gly 210 215 220 O:\92\92747.DOC -231- 200413407

Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala Ala Arg Gly Gin Leu 225 230 235 240

Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gin Leu Ser Gly Gin Val 245 250 255

Arg Leu Leu Leu Gly Ala Leu Gin Ser Leu Leu Gly Thr Gin Leu Pro 260 265 270

Pro Gin Gly Arg Thr Thr Ala His Lys Asp Pro Asn Ala lie Phe Leu 275 280 285

Ser Phe Gin His Leu Leu Arg Gly Lys Val Arg Phe Leu Met Leu Val 290 295 300

Gly Gly Ser Thr Leu Cys Val Arg 305 310 (2)序列編號NO: 470資料： (i) 序列特性： (A) 長度：313胺基酸

(B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 470

Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser Lys Leu Leu 15 10 15

Arg Asp Ser His Val Leu His Ser Arg Leu Ser Gin Cys Pro Glu Val 20 25 30

His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala Val Asp Phe Ser Leu 35 40 45

Gly Glu Trp Lys Thr Gin Met Glu Glu Thr Lys Ala Gin Asp lie Leu 50 55 60

Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala Ala Arg Gly Gin 65 70 75 80

Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gin Leu Ser Gly Gin 85 90 95

Val Arg Leu Leu Leu Gly Ala Leu Gin Ser Leu Leu Gly Thr Gin Leu 100 105 110

Pro Pro Gin Gly Arg Thr Thr Ala His Lys Asp Pro Asn Ala lie Phe 115 120 125

Leu Ser Phe Gin His Leu Leu Arg Gly Lys Val Arg Phe Leu Met Leu 130 135 140

Val Gly Gly Ser Thr Leu Cys Val Arg Glu Phe Gly Gly Asn Met Ala 145 150 155 160

Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser Lys Leu Leu 165 170 175

Arg Asp Ser His Val Leu His Ser Arg Leu Ser Gin Cys Pro Glu Val 180 185 190

His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala Val Asp Phe Ser Leu 195 200 205

Gly Glu Trp Lys Thr Gin Met Glu Glu Thr Lys Ala Gin Asp lie Leu 210 215 220

Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala Ala Arg Gly Gin 225 230 235 240 O:\92\92747.DOC 232- 200413407

Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gin Leu Ser Gly Gin 245 250 255

Val Arg Leu Leu Leu Gly Ala Leu Gin Ser Leu Leu Gly Thr Gin Leu 260 265 270

Pro Pro Gin Gly Arg Thr Thr Ala His Lys Asp Pro Asn Ala lie Phe 275 280 285

Leu Ser Phe Gin His Leu Leu Arg Gly Lys Val Arg Phe Leu Met Leu 290 295 300

Val Gly Gly Ser Thr Leu Cys Val Arg 305 310 (2)序列編號NO: 471資料： (i) 序列特性： (A) 長度：316胺基酸

(B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO.· 471

Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser Lys Leu Leu 15 10 15

Arg Asp Ser His Val Leu His Ser Arg Leu Ser Gin Cys Pro Glu Val 20 25 30

His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala Val Asp Phe Ser Leu 35 40 45

Gly Glu Trp Lys Thr Gin Met Glu Glu Thr Lys Ala Gin Asp lie Leu 50 55 60

Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala Ala Arg Gly Gin

65 70 75 80

Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gin Leu Ser Gly Gin 85 90 95

Val Arg Leu Leu Leu Gly Ala Leu Gin Ser Leu Leu Gly Thr Gin Leu 100 105 110

Pro Pro Gin Gly Arg Thr Thr Ala His Lys Asp Pro Asn Ala He Phe 115 120 125

Leu Ser Phe Gin His Leu Leu Arg Gly Lys Val Arg Phe Leu Met Leu 130 135 140

Val Gly Gly Ser Thr Leu Cys Val Arg Glu Phe Gly Gly Asn Gly Gly 145 150 155 160

Asn Met Ala Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser 165 170 175

Lys Leu Leu Arg Asp Ser His Val Leu His Ser Arg Leu Ser Gin Cys 180 185 190

Pro Glu Val His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala Val Asp 195 200 205

Phe Ser Leu Gly Glu Trp Lys Thr Gin Met Glu Glu Thr Lys Ala Gin 210 215 220

Asp lie Leu Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala Ala 225 230 235 240

Arg Gly Gin Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gin Leu O:\92\92747.DOC -233- 245 250 255

Ser Gly Gin Val Arg Leu Leu Leu Gly Ala Leu Gin Ser Leu Leu Gly 260 265 270

Thr Gin Leu Pro Pro Gin Gly Arg Thr Thr Ala His Lys Asp Pro Asn 275 280 285

Ala He Phe Leu Ser Phe Gin His Leu Leu Arg Gly Lys Val Arg Phe 290 295 300

Leu Met Leu Val Gly Gly Ser Thr Leu Cys Val Arg 305 310 315 (2)序列編號NO: 472資料： (i) 序列特性： (A) 長度：302胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 472

Asn Cys Ser lie Met lie Asp Glu lie He His His Leu Lys Arg Pro 15 10 15

Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val Ser 20 25 30 lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val 35 40 45

Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly He Glu Ala He Leu 50 55 60

Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg 65 70 75 80

His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu Lys 85 90 95

Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin Tyr 100 105 110

Val Glu Gly Gly Gly Gly Ser Pro Gly Gly Gly Ser Gly Gly Gly Ser 115 120 125

Asn Met Ala Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly 130 135 140

His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gin 145 150 155 160

Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser Gly Leu Phe 165 170 175

Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie Ser Pro Glu Leu 180 185 190

Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala Asp Phe Ala Thr 195 200 205

Thr lie Trp Gin Gin Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gin 210 215 220

Pro Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gin Arg Arg 225 230 235 240

Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser Phe Leu Glu Val 245 250 255 -234-

O:\92\92747.DOC 200413407

Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro Ser Gly Gly Ser Gly 260 265 270

Gly Ser Gin Ser Phe Leu Leu Lys Ser Leu Glu Gin Val Arg Lys lie 275 280 285

Gin Gly Asp Gly Ala Ala Leu Gin Glu Lys Leu Cys Ala Thr 290 295 300 (2)序列編號NO: 473資料： (i) 序列特性： (A) 長度：317胺基酸 (B) 形式：胺基酸 (C) 股數：單

(D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 473

Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg Pro 15 10 15

Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala He Leu 50 55 60

Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg 65 70 75 80

His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu Lys 85 90 95

Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin Tyr 100 105 110

Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He Ser 115 120 125

Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn 130 135 140

Met Ala Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His 145 150 155 160

Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gin Ala 165 170 175

Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser Gly Leu Phe Leu 180 185 190

Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly He Ser Pro Glu Leu Gly 195 200 205

Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala Asp Phe Ala Thr Thr 210 215 220 lie Trp Gin Gin Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gin Pro 225 230 235 240

Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gin Arg Arg Ala 245 250 255

Gly Gly Val Leu Val Ala Ser His Leu Gin Ser Phe Leu Glu Val Ser 260 265 270

Tyr Arg Val Leu Arg His Leu Ala Gin Pro Ser Gly Gly Ser Gly Gly 275 280 285 O:\92\92747.DOC -235 200413407

Ser Gin Ser Phe Leu Leu Lys Ser Leu Glu Gin Val Arg Lys lie Gin 290 295 300

Gly Asp Gly Ala Ala Leu Gin Glu Lys Leu Cys Ala Thr 305 310 315 (2)序列編號NO: 474資料： (i) 序列特性： (A) 長度：302胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形

(ii) 分子類型：無 (xi)序列描述：序列編號NO: 474

Asn Cys Ser He Met lie Asp Glu He lie His His Leu Lys Arg Pro 15 10 15

Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie Leu 50 55 60

Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg 65 70 75 80

His Pro He He lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu Lys 85 90 95

Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin Tyr 100 105 110

Val Glu Gly Gly Gly Gly Ser Pro Gly Gly Gly Ser Gly Gly Gly Ser 115 120 125

Asn Met Ala Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp 130 135 140

Val Ala Asp Phe Ala Thr Thr lie Trp Gin Gin Met Glu Glu Leu Gly 145 150 155 160

Met Ala Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe Ala 165 170 175

Ser Ala Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu 180 185 190

Gin Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin 195 200 205

Pro Ser Gly Gly Ser Gly Gly Ser Gin Ser Phe Leu Leu Lys Ser Leu 210 215 220

Glu Gin Val Arg Lys lie Gin Gly Asp Gly Ala Ala Leu Gin Glu Lys 225 230 235 240

Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu 245 250 255

Gly His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser 260 265 270

Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser Gly Leu 275 280 285

Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie Ser 290 295 300 O:\92\92747.DOC -236- 200413407 (2)序列編號NO: 475資料： (i) 序列特性： (A) 長度：317胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 475

Asn Cys Ser lie Met He Asp Glu lie lie His His Leu Lys Arg Pro 15 10 15

Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie Leu 50 55 60

Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg 65 70 75 80

His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu Lys 85 90 95

Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin Tyr 100 105 110

Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He Ser 115 120 125

Thr He Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn 130 135 140

Met Ala Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val 145 150 155 160

Ala Asp Phe Ala Thr Thr lie Trp Gin Gin Met Glu Glu Leu Gly Met 165 170 175

Ala Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe Ala Ser 180 185 190

Ala Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin 195 200 205

Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro 210 215 220

Ser Gly Gly Ser Gly Gly Ser Gin Ser Phe Leu Leu Lys Ser Leu Glu 225 230 235 240

Gin Val Arg Lys lie Gin Gly Asp Gly Ala Ala Leu Gin Glu Lys Leu 245 250 255

Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly 260 265 270

His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gin 275 280 285

Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser Gly Leu Phe 290 295 300

Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie Ser 305 310 315 O:\92\92747.DOC -237- 200413407 (2)序列編號NO: 476資料： (i) 序列特性： (A) 長度：302胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 476

Asn Cys Ser He Met lie Asp Glu lie lie His His Leu Lys Arg Pro 15 10 15

Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala He Leu 50 55 60

Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg 65 70 75 80

His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu Lys 85 90 95

Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin Tyr 100 105 110

Val Glu Gly Gly Gly Gly Ser Pro Gly Gly Gly Ser Gly Gly Gly Ser 115 120 125

Asn Met Ala Met Ala Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro 130 135 140

Ala Phe Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala 145 150 155 160

Ser His Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His 165 170 175

Leu Ala Gin Pro Ser Gly Gly Ser Gly Gly Ser Gin Ser Phe Leu Leu 180 185 190

Lys Ser Leu Glu Gin Val Arg Lys lie Gin Gly Asp Gly Ala Ala Leu 195 200 205

Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 210 215 220

Val Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser 225 230 235 240

Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His 245 250 255

Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly He 260 265 270

Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala 275 280 285

Asp Phe Ala Thr Thr lie Trp Gin Gin Met Glu Glu Leu Gly 290 295 300 (2)序列編號NO: 477資料： O:\92\92747.DOC -238- 200413407 (i) 序列特性： (A) 長度：317胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 477

Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg Pro 15 10 15

Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie Leu 50 55 60

Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg 65 70 75 80

His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu Lys 85 90 95

Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin Tyr 100 105 110

Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie Ser 115 120 125

Thr He Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn 130 135 140

Met Ala Met Ala Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala 145 150 155 160

Phe Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser 165 170 175

His Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu 180 185 190

Ala Gin Pro Ser Gly Gly Ser Gly Gly Ser Gin Ser Phe Leu Leu Lys 195 200 205

Ser Leu Glu Gin Val Arg Lys lie Gin Gly Asp Gly Ala Ala Leu Gin 210 215 220

Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val 225 230 235 240

Leu Leu Gly His Ser Leu Gly He Pro Trp Ala Pro Leu Ser Ser Cys 245 250 255

Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser 260 265 270

Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie Ser 275 280 285

Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala Asp 290 295 300

Phe Ala Thr Thr lie Trp Gin Gin Met Glu Glu Leu Gly 305 310 315 (2)序列編號NO: 478資料： O:\92\92747.DOC 239- 200413407 (i) 序列特性： (A) 長度：302胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 478

Asn Cys Ser He Met lie Asp Glu lie lie His His Leu Lys Arg Pro 15 10 15

Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala He Leu 50 55 60

Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg 65 70 75 80

His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu Lys 85 90 95

Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin Tyr 100 105 110

Val Glu Gly Gly Gly Gly Ser Pro Gly Gly Gly Ser Gly Gly Gly Ser 115 120 125

Asn Met Ala Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gin 130 135 140

Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser Phe Leu 145 150 155 160

Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro Ser Gly Gly 165 170 175

Ser Gly Gly Ser Gin Ser Phe Leu Leu Lys Ser Leu Glu Gin Val Arg 180 185 190

Lys lie Gin Gly Asp Gly Ala Ala Leu Gin Glu Lys Leu Cys Ala Thr 195 200 205

Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu 210 215 220

Gly He Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin 225 230 235 240

Leu Ala Gly Cys Leu Ser Gin Leu His Ser Gly Leu Phe Leu Tyr Gin 245 250 255

Gly Leu Leu Gin Ala Leu Glu Gly lie Ser Pro Glu Leu Gly Pro Thr 260 265 270

Leu Asp Thr Leu Gin Leu Asp Val Ala Asp Phe Ala Thr Thr He Trp 275 280 285

Gin Gin Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gin Pro 290 295 300 (2)序列編號NO: 479資料： (i)序列特性： O:\92\92747.DOC -240- 200413407 (A) 長度：317胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 479

Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg Pro 15 10 15

Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val Ser 20 25 30

lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val 35 40 45

Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly He Glu Ala lie Leu 50 55 60

Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg 65 70 75 80

His Pro lie lie He Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu Lys 85 90 95

Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin Tyr 100 105 110

Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He Ser 115 120 125

Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn 130 135 140

Met Ala Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gin Arg 145 150 155 160

Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser Phe Leu Glu 165 170 175

Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro Ser Gly Gly Ser 180 185 190

Gly Gly Ser Gin Ser Phe Leu Leu Lys Ser Leu Glu Gin Val Arg Lys 195 200 205 lie Gin Gly Asp Gly Ala Ala Leu Gin Glu Lys Leu Cys Ala Thr Tyr 210 215 220

Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly 225 230 235 240 lie Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu 245 250 255

Ala Gly Cys Leu Ser Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly 260 265 270

Leu Leu Gin Ala Leu Glu Gly He Ser Pro Glu Leu Gly Pro Thr Leu 275 280 285

Asp Thr Leu Gin Leu Asp Val Ala Asp Phe Ala Thr Thr He Trp Gin 290 295 300

Gin Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gin Pro 305 310 315 (2)序列編號NO: 480資料： (i)序列特性： O:\92\92747.DOC -241- 200413407 (A) 長度：302胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 480

Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg Pro 15 10 15

Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val Ser 20 25 30

lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val 35 40 45

Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie Leu 50 55 60

Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg 65 70 75 80

His Pro He lie He Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu Lys 85 90 95

Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin Tyr 100 105 110

Val Glu Gly Gly Gly Gly Ser Pro Gly Gly Gly Ser Gly Gly Gly Ser 115 120 125

Asn Met Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala 130 135 140

Ser His Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His 145 150 155 160

Leu Ala Gin Pro Ser Gly Gly Ser Gly Gly Ser Gin Ser Phe Leu Leu 165 170 175

Lys Ser Leu Glu Gin Val Arg Lys lie Gin Gly Asp Gly Ala Ala Leu 180 185 190

Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 195 200 205

Val Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser 210 215 220

Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His 225 230 235 240

Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie 245 250 255

Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala 260 265 270

Asp Phe Ala Thr Thr He Trp Gin Gin Met Glu Glu Leu Gly Met Ala 275 280 285

Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe Ala 290 295 300 (2)序列編號NO: 481資料： (i)序列特性： (A)長度：317胺基酸 O:\92\92747.DOC .242- 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 481

Asn Cys Ser lie Met He Asp Glu lie He His His Leu Lys Arg Pro 15 10 15

Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala He Leu 50 55 60

Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg 65 70 75 80

His Pro lie lie He Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu Lys 85 90 95

Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin Tyr 100 105 110

Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He Ser 115 120 125

Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn 130 135 140

Met Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser 145 150 155 160

His Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu 165 170 175

Ala Gin Pro Ser Gly Gly Ser Gly Gly Ser Gin Ser Phe Leu Leu Lys 180 185 190

Ser Leu Glu Gin Val Arg Lys lie Gin Gly Asp Gly Ala Ala Leu Gin 195 200 205

Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val 210 215 220

Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys 225 230 235 240

Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser 245 250 255

Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie Ser 260 265 270

Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala Asp 275 280 285

Phe Ala Thr Thr lie Trp Gin Gin Met Glu Glu Leu Gly Met Ala Pro 290 295 300

Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe Ala 305 310 315 (2)序列編號NO·· 482資料： (i)序列特性： (A)長度：305胺基酸 O:\92\92747.DOC 243- 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (Π)分子類型：無 (xi)序列描述：序列編號NO: 482

Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg Pro 15 10 15

Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie Leu 50 55 60

Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg 65 70 75 80

His Pro He lie He Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu Lys 85 90 95

Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin Tyr 100 105 110

Val Glu Gly Gly Gly Gly Ser Pro Gly Gly Gly Ser Gly Gly Gly Ser 115 120 125

Asn Met Ala Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly 130 135 140

His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gin 145 150 155 160

Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser Gly Leu Phe 165 170 175

Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie Ser Pro Glu Leu 180 185 190

Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala Asp Phe Ala Thr 195 200 205

Thr lie Trp Gin Gin Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gin 210 215 220

Pro Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gin Arg Arg 225 230 235 240

Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser Phe Leu Glu- Val 245 250 255

Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro Thr Pro Leu Gly Pro 260 265 270

Ala Ser Ser Leu Pro Gin Ser Phe Leu Leu Lys Ser Leu Glu Gin Val 275 280 285

Arg Lys lie Gin Gly Asp Gly Ala Ala Leu Gin Glu Lys Leu Cys Ala 290 295 300

Thr 305 (2)序列編號NO: 483資料： (i)序列特性： (A)長度：320胺基酸 O:\92\92747.DOC 244- 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 483

Asn Cys Ser He Met lie Asp Glu lie He His His Leu Lys Arg Pro 15 10 15

Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie Leu 50 55 60

Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg 65 70 75 80

His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu Lys 85 90 95

Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin Tyr 100 105 110

Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He Ser 115 120 125

Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn 130 135 140

Met Ala Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His 145 150 155 160

Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gin Ala 165 170 175

Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser Gly Leu Phe Leu 180 185 190

Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie Ser Pro Glu Leu Gly 195 200 205

Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gin Arg Arg Ala 245 250 255

Gly Gly Val Leu Val Ala Ser His Leu Gin Ser Phe Leu Glu Val Ser 260 265 270

Tyr Arg Val Leu Arg His Leu Ala Gin Pro Thr Pro Leu Gly Pro Ala 275 280 285

Ser Ser Leu Pro Gin Ser Phe Leu Leu Lys Ser Leu Glu Gin Val Arg 290 295 300

Lys He Gin Gly Asp Gly Ala Ala Leu Gin Glu Lys Leu Cys Ala Thr 305 310 315 320 (2)序列編號NO: 484資料： (i)序列特性： (A)長度：305胺基酸 O:\92\92747.DOC .245- 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 484

Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg Pro 15 10 15

Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie Leu 50 55 60

Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg 65 70 75 80

His Pro lie lie He Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu Lys 85 90 95

Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin Tyr 100 105 110

Val Glu Gly Gly Gly Gly Ser Pro Gly Gly Gly Ser Gly Gly Gly Ser 115 120 125

Asn Met Ala Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp 130 135 140

Val Ala Asp Phe Ala Thr Thr He Trp Gin Gin Met Glu Glu Leu Gly 145 150 155 160

Met Ala Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe Ala 165 170 175

Ser Ala Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu 180 185 190

Gin Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin 195 200 205

Pro Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser Phe Leu Leu 210 215 220

Lys Ser Leu Glu Gin Val Arg Lys lie Gin Gly Asp Gly Ala Ala Leu 225 230 235 240

Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 245 250 255

Val Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser 260 265 270

Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His 275 280 285

Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie 290 295 300

Ser 305 (2)序列編號NO: 485資料： (i)序列特性： (A)長度：320胺基酸 O:\92\92747.DOC -246 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 485

Asn Cys Ser lie Met lie Asp Glu He lie His His Leu Lys Arg Pro 15 10 15

Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie Leu 50 55 60

Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg 65 70 75 80

His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu Lys 85 90 95

Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin Tyr 100 105 110

Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He Ser 115 120 125

Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn 130 135 140

Met Ala Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val 145 150 155 160

Ala Asp Phe Ala Thr Thr lie Trp Gin Gin Met Glu Glu Leu Gly Met 165 170 175

Ala Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe Ala Ser 180 185 190

Ala Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin 195 200 205

Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro 210 215 220

Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser Phe Leu Leu Lys 225 230 235 240

Ser Leu Glu Gin Val Arg Lys lie Gin Gly Asp Gly Ala Ala Leu Gin 245 250 255

Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val 260 265 270

Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys 275 280 285

Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser 290 295 300

Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie Ser 305 310 315 320 (2)序列編號NO: 486資料： (i)序列特性： (A)長度：305胺基酸 -247-

O:\92\92747.DOC 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 486

Asn Cys Ser lie Met lie Asp Glu He lie His His Leu Lys Arg Pro 15 10 15

Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly He Glu Ala lie Leu 50 55 60

Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg 65 70 75 80

His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu Lys 85 90 95

Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin Tyr 100 105 110

Val Glu Gly Gly Gly Gly Ser Pro Gly Gly Gly Ser Gly Gly Gly Ser 115 120 125

Asn Met Ala Met Ala Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro 130 135 140

Ala Phe Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala 145 150 155 160

Ser His Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His 165 170 175

Leu Ala Gin Pro Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser 180 185 190

Phe Leu Leu Lys Ser Leu Glu Gin Val Arg Lys He Gin Gly Asp Gly 195 200 205

Ala Ala Leu Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro 210 215 220

Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala Pro 225 230 235 240

Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser 245 250 255

Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu 260 265 270

Glu Gly lie Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu 275 280 285

Asp Val Ala Asp Phe Ala Thr Thr He Trp Gin Gin Met Glu Glu Leu 290 295 300

Gly 305 (2)序列編號NO: 487資料： (i)序列特性： (A) 長度：320胺基酸 (B) 形式：胺基酸 O:\92\92747.DOC 248 200413407 (c)股數：單 (D)拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 487

Asn Cys Ser lie Met He Asp Glu lie lie His His Leu Lys Arg Pro 15 10 15

Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie Leu 50 55 60

Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg

65 70 75 80

His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu Lys 85 90 95

Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin Tyr 100 105 110

Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie Ser 115 120 125

Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn 130 135 140

Met Ala Met Ala Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala 145 150 155 160

Phe Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser 165 170 175

His Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu 180 185 190

Ala Gin Pro Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser Phe 195 200 205

Leu Leu Lys Ser Leu Glu Gin Val Arg Lys lie Gin Gly Asp Gly Ala 210 215 220

Ala Leu Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu

225 230 235 240

Glu Leu Val Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala Pro Leu 245 250 255

Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin 260 265 270

Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu 275 280 285

Gly He Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp 290 295 300

Val Ala Asp Phe Ala Thr Thr He Trp Gin Gin Met Glu Glu Leu Gly 305 310 315 320 (2)序列編號NO: 488資料： (i)序列特性： (A) 長度：305胺基酸 (B) 形式·胺基酸 O:\92\92747.DOC -249- 200413407 (c)股數：單 (D)拓撲結構：線形 (Π)分子類型：無 (xi)序列描述：序列編號NO: 488

Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg Pro 15 10 15

Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val Ser 20 25 30

He Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val 35 40 45

Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie Leu 50 55 60

Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg

65 70 75 80

His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu Lys 85 90 95

Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin Tyr 100 105 110

Val Glu Gly Gly Gly Gly Ser Pro Gly Gly Gly Ser Gly Gly Gly Ser 115 120 125

Asn Met Ala Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gin 130 135 140

Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser Phe Leu 145 150 155 160

Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro Thr Pro Leu 165 170 175

Gly Pro Ala Ser Ser Leu Pro Gin Ser Phe Leu Leu Lys Ser Leu Glu 180 185 190

Gin Val Arg Lys lie Gin Gly Asp Gly Ala Ala Leu Gin Glu Lys Leu 195 200 205

Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly 210 215 220

His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gin

225 230 235 240

Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser Gly Leu Phe 245 250 255

Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly He Ser Pro Glu Leu 260 265 270

Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala Asp Phe Ala Thr 275 280 285

Thr lie Trp Gin Gin Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gin 290 295 300

Pro 305 (2)序列編號NO: 489資料： (i)序列特性： (A) 長度：320胺基酸 (B) 形式：胺基酸 O:\92\92747.DOC -250- 200413407 (c)股數：單 (D)拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 489

Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg Pro 15 10 15

Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie Leu 50 55 60

Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg

65 70 75 80

His Pro lie lie He Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu Lys 85 90 95

Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin Tyr 100 105 110

Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie Ser 115 120 125

Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn 130 135 140

Met Ala Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gin Arg 145 150 155 160

Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser Phe Leu Glu 165 170 175

Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro Thr Pro Leu Gly 180 185 190

Pro Ala Ser Ser Leu Pro Gin Ser Phe Leu Leu Lys Ser Leu Glu Gin 195 200 205

Val Arg Lys lie Gin Gly Asp Gly Ala Ala Leu Gin Glu Lys Leu Cys 210 215 220

Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His

225 230 235 240

Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gin Ala 245 250 255

Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser Gly Leu Phe Leu 260 265 270

Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie Ser Pro Glu Leu Gly 275 280 285

Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala Asp Phe Ala Thr Thr 290 295 300

He Trp Gin Gin Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gin Pro 305 310 315 320 (2)序列編號NO: 490資料： (i)序列特性： (A) 長度：305胺基酸 (B) 形式：胺基酸 O:\92\92747.DOC -251- 200413407 (c)股數：單 (D)拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 490

Asn Cys Ser He Met lie Asp Glu lie lie His His Leu Lys Arg Pro 15 10 15

Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie Leu 50 55 60

Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg

65 70 75 80

His Pro lie He He Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu Lys 85 90 95

Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin Tyr 100 105 110

Val Glu Gly Gly Gly Gly Ser Pro Gly Gly Gly Ser Gly Gly Gly Ser 115 120 125

Asn Met Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala 130 135 140

Ser His Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His 145 150 155 160

Leu Ala Gin Pro Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser 165 170 175

Phe Leu Leu Lys Ser Leu Glu Gin Val Arg Lys lie Gin Gly Asp Gly 180 185 190

Ala Ala Leu Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro 195 200 205

Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala Pro 210 215 220

Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser

225 230 235 240

Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu 245 250 255

Glu Gly lie Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu 260 265 270

Asp Val Ala Asp Phe Ala Thr Thr lie Trp Gin Gin Met Glu Glu Leu 275 280 285

Gly Met Ala Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe 290 295 300

Ala 305 (2)序列編號NO: 491資料： (i)序列特性： (A) 長度：320胺基酸 (B) 形式：胺基酸 O:\92\92747.DOC -252- 200413407 (c)股數：單 (D)拓撲結構：線形 (Π)分子類型：無 (xi)序列描述：序列編號NO: 491

Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg Pro 15 10 15

Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie Leu 50 55 60

Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg

65 70 75 80

His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu Lys 85 90 95

Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin Tyr 100 105 110

Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie Ser 115 120 125

Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn 130 135 140

Met Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser 145 150 155 160

His Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu 165 170 175

Ala Gin Pro Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser Phe 180 185 190

Leu Leu Lys Ser Leu Glu Gin Val Arg Lys lie Gin Gly Asp Gly Ala 195 200 205

Ala Leu Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu 210 215 220

Glu Leu Val Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala Pro Leu

225 230 235 240

Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin 245 250 255

Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu 260 265 270

Gly lie Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp 275 280 285

Val Ala Asp Phe Ala Thr Thr lie Trp Gin Gin Met Glu Glu Leu Gly 290 295 300

Met Ala Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe Ala 305 310 315 320 (2)序列編號NO: 492資料： (i)序列特性： (A) 長度：321胺基酸 (B) 形式：胺基酸 O:\92\92747.DOC -253- 200413407 (c)股數：單 (D)拓撲結構：線形 (Π)分子類型：無 (xi)序列描述：序列編號NO: 492

Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val Ser lie Leu Met Asp 15 10 15

Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys 20 25 30

Asn Leu Glu Asn Ala Ser Gly lie Glu Ala He Leu Arg Asn Leu Gin 35 40 45

Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro lie lie 50 55 60 lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu Lys Leu Thr Phe Tyr

65 70 75 80

Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin Gly Gly Gly Ser Asn 85 90 95

Cys Ser lie Met He Asp Glu He lie His His Leu Lys Arg Pro Pro 100 105 110

Ala Pro Leu Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser 115 120 125

Gly Pro lie Ser Thr He Asn Pro Ser Pro Pro Ser Lys Glu Ser His 130 135 140

Lys Ser Pro Asn Met Ala Thr Gin Gly Ala Met Pro Ala Phe Ala Ser 145 150 155 160

Ala Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin 165 170 175

Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro 180 185 190

Ser Gly Gly Ser Gly Gly Ser Gin Ser Phe Leu Leu Lys Ser Leu Glu 195 200 205

Gin Val Arg Lys lie Gin Gly Asp Gly Ala Ala Leu Gin Glu Lys Leu 210 215 220

Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly

225 230 235 240

His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gin 245 250 255

Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser Gly Leu Phe 260 265 270

Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie Ser Pro Glu Leu 275 280 285

Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala Asp Phe Ala Thr 290 295 300

Thr He Trp Gin Gin Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gin 305 310 315 320

Pro (2)序列編號NO: 493資料： (i)序列特性： (A) 長度：321胺基酸 (B) 形式：胺基酸 O:\92\92747.DOC -254 200413407 (c)股數：單 (D)拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 493

Asn Ala Ser Gly He Glu Ala lie Leu Arg Asn Leu Gin Pro Cys Leu 15 10 15

Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro lie lie lie Lys Ala 20 25 30

Gly Asp Trp Gin Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr 35 40 45

Leu Glu Gin Ala Gin Glu Gin Gin Gly Gly Gly Ser Asn Cys Ser He 50 55 60

Met lie Asp Glu lie lie His His Leu Lys Arg Pro Pro Ala Pro Leu

65 70 75 80

Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val Ser lie Leu Met Asp 85 90 95

Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys 100 105 110

Asn Leu Glu Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser 115 120 125

Gly Pro lie Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His 130 135 140

Lys Ser Pro Asn Met Ala Thr Gin Gly Ala Met Pro Ala Phe Ala Ser 145 150 155 160

Ala Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin 165 170 175

Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro 180 185 190

Ser Gly Gly Ser Gly Gly Ser Gin Ser Phe Leu Leu Lys Ser Leu Glu 195 200 205

Gin Val Arg Lys lie Gin Gly Asp Gly Ala Ala Leu Gin Glu Lys Leu 210 215 220

Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly

225 230 235 240

His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gin 245 250 255

Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser Gly Leu Phe 260 265 270

Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie Ser Pro Glu Leu 275 280 285

Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala Asp Phe Ala Thr 290 295 300

Thr lie Trp Gin Gin Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gin 305 310 315 320

Pro (2)序列編號NO: 494資料： (i)序列特性： (A) 長度：321胺基酸 (B) 形式：胺基酸 O:\92\92747.DOC -255- 200413407 (c)股數：單 (D)拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 494

Ala Pro Ser Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu 15 10 15

Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin 20 25 30

Glu Gin Gin Gly Gly Gly Ser Asn Cys Ser He Met lie Asp Glu lie 35 40 45

He His His Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn 50 55 60

Leu Asn Asp Glu Asp Val Ser lie Leu Met Asp Arg Asn Leu Arg Leu

65 70 75 80

Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala 85 90 95

Ser Gly lie Glu Ala lie Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser 100 105 110

Ala Thr Ala Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser 115 120 125

Gly Pro lie Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His 130 135 140

Lys Ser Pro Asn Met Ala Thr Gin Gly Ala Met Pro Ala Phe Ala Ser 145 150 155 160

Ala Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin 165 170 175

Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro 180 185 190

Ser Gly Gly Ser Gly Gly Ser Gin Ser Phe Leu Leu Lys Ser Leu Glu 195 200 205

Gin Val Arg Lys lie Gin Gly Asp Gly Ala Ala Leu Gin Glu Lys Leu 210 215 220

Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly

225 230 235 240

His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gin 245 250 255

Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser Gly Leu Phe 260 265 - 270

Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie Ser Pro Glu Leu 275 280 285

Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala Asp Phe Ala Thr 290 295 300

Thr He Trp Gin Gin Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gin 305 310 315 320

Pro (2)序列編號NO: 495資料： (i)序列特性： (A) 長度：321胺基酸 (B) 形式：胺基酸 O:\92\92747.DOC -256- 200413407 (c)股數：單 (D)拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 495

Ala Gly Asp Trp Gin Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val 15 10 15

Thr Leu Glu Gin Ala Gin Glu Gin Gin Gly Gly Gly Ser Asn Cys Ser 20 25 30 lie Met He Asp Glu lie He His His Leu Lys Arg Pro Pro Ala Pro 35 40 45

Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val Ser lie Leu Met 50 55 60

Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val

65 70 75 80

Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie Leu Arg Asn Leu 85 90 95

Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro lie 100 105 110 lie He Lys Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser 115 120 125

Gly Pro He Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His 130 135 140

Lys Ser Pro Asn Met Ala Thr Gin Gly Ala Met Pro Ala Phe Ala Ser 145 150 155 160

Ala Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin 165 170 175

Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro 180 185 190

Ser Gly Gly Ser Gly Gly Ser Gin Ser Phe Leu Leu Lys Ser Leu Glu 195 200 205

Gin Val Arg Lys lie Gin Gly Asp Gly Ala Ala Leu Gin Glu Lys Leu 210 215 220

Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly

225 230 235 240

His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gin 245 250 255

Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser Gly Leu Phe 260 265 270

Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie Ser Pro Glu Leu 275 280 285

Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala Asp Phe Ala Thr 290 295 300

Thr lie Trp Gin Gin Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gin 305 310 315 320

Pro (2)序列編號NO: 496資料： (i)序列特性： (A) 長度：329胺基酸 (B) 形式：胺基酸 O:\92\92747.DOC -257- 200413407 (c)股數··單 (D)拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 496

Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val Ser He Leu Met Asp 15 10 15

Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg Ala Val Lys 20 25 30

Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie Leu Arg Asn Leu Gin 35 40 45

Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro lie He 50 55 60 lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu Lys Leu Thr Phe Tyr

65 70 75 80

Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin Gly Gly Gly Ser Gly 85 90 95

Gly Gly Ser Gly Gly Gly Ser Asn Cys Ser He Met lie Asp Glu He 100 105 110 lie His His Leu Lys Arg Pro Pro Ala Pro Leu Tyr Val Glu Gly Gly 115 120 125

Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie Ser Thr lie Asn Pro 130 135 140

Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Thr Gin 145 150 155 160

Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly 165 170 175

Val Leu Val Ala Ser His Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg 180 185 190

Val Leu Arg His Leu Ala Gin Pro Ser Gly Gly Ser Gly Gly Ser Gin 195 200 205

Ser Phe Leu Leu Lys Ser Leu Glu Gin Val Arg Lys lie Gin Gly Asp 210 215 220

Gly Ala Ala Leu Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His

225 230 235 240

Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala 245 250 255

Pro Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu 260 265 270

Ser Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala 275 280 285

Leu Glu Gly lie Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin 290 295 300

Leu Asp Val Ala Asp Phe Ala Thr Thr lie Trp Gin Gin Met Glu Glu 305 310 315 320

Leu Gly Met Ala Pro Ala Leu Gin Pro 325 (2)序列編號NO: 497資料： (i)序列特性： (A) 長度：329胺基酸 (B) 形式：胺基酸 O:\92\92747.DOC .258- 200413407 (c)股數：單 (D)拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 497

Asn Ala Ser Gly lie Glu Ala lie Leu Arg Asn Leu Gin Pro Cys Leu 15 10 15

Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro lie lie lie Lys Ala 20 25 30

Gly Asp Trp Gin Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr 35 40 45

Leu Glu Gin Ala Gin Glu Gin Gin Gly Gly Gly Ser Gly Gly Gly Ser 50 55 60

Gly Gly Gly Ser Asn Cys Ser lie Met lie Asp Glu lie lie His His 65 70 75 80

Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp 85 90 95

Glu Asp Val Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu 100 105 110

Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Tyr Val Glu Gly Gly 115 120 125

Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He Ser Thr lie Asn Pro 130 135 140

Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Thr Gin 145 150 155 160

Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly 165 170 175

Val Leu Val Ala Ser His Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg 180 185 190

Val Leu Arg His Leu Ala Gin Pro Ser Gly Gly Ser Gly Gly Ser Gin 195 200 205

Ser Phe Leu Leu Lys Ser Leu Glu Gin Val Arg Lys lie Gin Gly Asp 210 215 220

Gly Ala Ala Leu Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His

225 230 235 240

Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala 245 250 255

Pro Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu 260 265 270

Ser Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala 275 280 285

Leu Glu Gly lie Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin 290 295 300

Leu Asp Val Ala Asp Phe Ala Thr Thr lie Trp Gin Gin Met Glu Glu 305 310 315 320

Leu Gly Met Ala Pro Ala Leu Gin Pro 325 (2)序列編號NO: 498資料： (i)序列特性： (A) 長度：329胺基酸 (B) 形式：胺基酸 O:\92\92747.DOC -259- 200413407 (c)股數：單 (D)拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 498

Ala Pro Ser Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu 15 10 15

Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin 20 25 30

Glu Gin Gin Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Asn 35 40 45

Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg Pro Pro 50 55 60

Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val Ser lie 65 70 75 80

Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe Val Arg 85 90 95

Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie Leu Arg 100 105 110

Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Tyr Val Glu Gly Gly 115 120 125

Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie Ser Thr lie Asn Pro 130 135 140

Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Thr Gin 145 150 155 160

Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly 165 170 175

Val Leu Val Ala Ser His Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg 180 185 190

Val Leu Arg His Leu Ala Gin Pro Ser Gly Gly Ser Gly Gly Ser Gin 195 200 205

Ser Phe Leu Leu Lys Ser Leu Glu Gin Val Arg Lys He Gin Gly Asp 210 215 220

Gly Ala Ala Leu Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His

225 230 235 240

Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala 245 250 255

Pro Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu 260 265 270

Ser Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala 275 280 285

Leu Glu Gly He Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin 290 295 300

Leu Asp Val Ala Asp Phe Ala Thr Thr lie Trp Gin Gin Met Glu Glu 305 310 315 320

Leu Gly Met Ala Pro Ala Leu Gin Pro 325 (2)序列編號NO: 499資料： (i)序列特性： (A) 長度：329胺基酸 (B) 形式：胺基酸 O:\92\92747.DOC -260 200413407 (c)股數：單 (D)拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 499

Ala Gly Asp Trp Gin Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val 15 10 15

Thr Leu Glu Gin Ala Gin Glu Gin Gin Gly Gly Gly Ser Gly Gly Gly 20 25 30

Ser Gly Gly Gly Ser Asn Cys Ser lie Met lie Asp Glu lie lie His 35 40 45

His Leu Lys Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn 50 55 60

Asp Glu Asp Val Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn

65 70 75 80

Leu Glu Ser Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly 85 90 95 lie Glu Ala lie Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr 100 105 110

Ala Ala Pro Ser Arg His Pro lie He lie Lys Tyr Val Glu Gly Gly 115 120 125

Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie Ser Thr He Asn Pro 130 135 140

Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Thr Gin 145 150 155 160

Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly 165 170 175

Val Leu Val Ala Ser His Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg 180 185 190

Val Leu Arg His Leu Ala Gin Pro Ser Gly Gly Ser Gly Gly Ser Gin 195 200 205

Ser Phe Leu Leu Lys Ser Leu Glu Gin Val Arg Lys lie Gin Gly Asp 210 215 220

Gly Ala Ala Leu Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His

225 230 235 240

Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly He Pro Trp Ala 245 250 255

Pro Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu 260 265 270

Ser Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala 275 280 285

Leu Glu Gly lie Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin 290 295 300

Leu Asp Val Ala Asp Phe Ala Thr Thr lie Trp Gin Gin Met Glu Glu 305 310 315 320

Leu Gly Met Ala Pro Ala Leu Gin Pro 325 (2)序列編號NO: 500資料： (i)序列特性： (A)長度：329胺基酸 O:\92\92747.DOC -261- 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 500

Met Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys 15 10 15

Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp 20 25 30

Val Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser 35 40 45

Phe Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala 50 55 60 lie Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro 65 70 75 80

Ser Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg 85 90 95

Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin 100 105 110

Gin Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 115 120 125 lie Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 130 135 140

Pro Asn Met Ala Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu 145 150 155 160

Gly His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser 165 170 175

Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser Gly Leu 180 185 190

Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie Ser Pro Glu 195 200 205

Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala Asp Phe Ala 210 215 220

Thr Thr He Trp Gin Gin Met Glu Glu Leu Gly Met Ala Pro Ala Leu 225 230 235 240

Gin Pro Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gin Arg 245 250 255

Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser Phe Leu Glu 260 265 270

Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro Gly Gly Gly Ser 275 280 285

Asp Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser Phe 290 295 300

Leu Leu Lys Ser Leu Glu Gin Val Arg Lys lie Gin Gly Asp Gly Ala 305 310 315 320

Ala Leu Gin Glu Lys Leu Cys Ala Thr 325 (2)序列編號NO: 501資料： (i)序列特性： (A)長度：329胺基酸 O:\92\92747.DOC -262- 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 501

Met Ala Asn Cys Ser He Met He Asp Glu lie lie His His Leu Lys 1 5 10 15

Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp 20 25 30

Val Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser 35 40 45

Ser Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg 85 90 95

Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin 100 105 110

Pro Asn Met Ala Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu 145 150 155 160

Asp Val Ala Asp Phe Ala Thr Thr lie Trp Gin Gin Met Glu Glu Leu 165 170 175

Gly Met Ala Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe 180 185 190

Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His 195 200 205

Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala 210 215 220

Gin Pro Gly Gly Gly Ser Asp Met Ala Thr Pro Leu Gly Pro Ala Ser 225 230 235 240

Ser Leu Pro Gin Ser Phe Leu Leu Lys Ser Leu Glu Gin Val Arg Lys 245 250 255 lie Gin Gly Asp Gly Ala Ala Leu Gin Glu Lys Leu Cys Ala Thr Tyr 260 265 270

Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly 275 280 285 lie Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu 290 295 300

Ala Gly Cys Leu Ser Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly 305 310 315 320

Leu Leu Gin Ala Leu Glu Gly lie Ser 325 (2)序列編號NO: 502資料： (i)序列特性： (A)長度：329胺基酸 O:\92\92747.DOC -263- 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 502

Met Ala Asn Cys Ser lie Met lie Asp Glu lie He His His Leu Lys 15 10 15

Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp 20 25 30

Val Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser 35 40 45

Ser Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg 85 90 95

Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin 100 105 110

Gin Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 115 120 125

He Ser Thr He Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 130 135 140

Pro Asn Met Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly Val Leu Val 145 150 155 160

Ala Ser His Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg 165 170 175

His Leu Ala Gin Pro Gly Gly Gly Ser Asp Met Ala Thr Pro Leu Gly 180 185 190

Pro Ala Ser Ser Leu Pro Gin Ser Phe Leu Leu Lys Ser Leu Glu Gin 195 200 205

Val Arg Lys lie Gin Gly Asp Gly Ala Ala Leu Gin Glu Lys Leu Cys 210 215 220

Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His 225 230 235 240

Ser Leu Gly He Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gin Ala 245 250 255

Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser Gly Leu Phe Leu 260 265 270

Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly He Ser Pro Glu Leu Gly 275 280 285

Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala Asp Phe Ala Thr Thr 290 295 300

He Trp Gin Gin Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gin Pro 305 310 315 320

Thr Gin Gly Ala Met Pro Ala Phe Ala 325 (2)序列編號NO: 503資料： (i)序列特性： (A)長度：329胺基酸 O:\92\92747.DOC -264- 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (i i)分子類型：無 (xi)序列描述：序列編號NO·. 503

Met Ala Asn Cys Ser lie Met He Asp Glu lie lie His His Leu Lys 15 10 15

Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp 20 25 30

Val Ser He Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser 35 40 45

Ser Arg His Pro lie He lie Lys Ala Gly Asp Trp Gin Glu Phe Arg 85 90 95

Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin 100 105 110

Pro Asn Met Ala Met Ala Pro Ala Leu Gin Pro Thr Gin Gly Ala Met 145 150 155 160

Pro Ala Phe Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly Val Leu Val 165 170 175

Ala Ser His Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg 180 185 190

His Leu Ala Gin Pro Gly Gly Gly Ser Asp Met Ala Thr Pro Leu Gly 195 200 205

Pro Ala Ser Ser Leu Pro Gin Ser Phe Leu Leu Lys Ser Leu Glu Gin 210 215 220

Val Arg Lys lie Gin Gly Asp Gly Ala Ala Leu Gin Glu Lys Leu Cys 225 230 235 240

Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His 245 250 255

Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gin Ala 260 265 270

Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser Gly Leu Phe Leu 275 280 285

Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie Ser Pro Glu Leu Gly 290 295 300

Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala Asp Phe Ala Thr Thr 305 310 315 320 lie Trp Gin Gin Met Glu Glu Leu Gly 325 (2)序列編號NO: 504資料： (i)序列特性： (A)長度：329胺基酸 O:\92\92747.DOC -265- 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 504

Met Ala Asn Cys Ser lie Met He Asp Glu lie lie His His Leu Lys 15 10 15

Arg Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp 20 25 30

Val Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser 35 40 45

Ser Arg His Pro lie lie He Lys Ala Gly Asp Trp Gin Glu Phe Arg 85 90 95

Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin 100 105 110

Gin Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 115 120 125 lie Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 130 ' 135 140

Pro Asn Met Ala Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Phe 145 150 155 160

Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser Phe 165 170 175

Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro Gly Gly 180 185 190

Gly Ser Asp Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin 195 200 205

Ser Phe Leu Leu Lys Ser Leu Glu Gin Val Arg Lys He Gin Gly Asp 210 215 220

Gly Ala Ala Leu Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His 225 230 235 240

Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala 245 250 255

Pro Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu 260 265 270

Ser Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala 275 280 285

Leu Glu Gly He Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin 290 295 300

Leu Asp Val Ala Asp Phe Ala Thr Thr lie Trp Gin Gin Met Glu Glu 305 310 315 320

Leu Gly Met Ala Pro Ala Leu Gin Pro 325 (2)序列編號NO: 505資料： (i)序列特性： (A)長度：319胺基酸 O:\92\92747.DOC -266 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 505

Met Ala Asn Cys Ser Asn Met He Asp Glu He lie Thr His Leu Lys 15 10 15

Gin Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp 20 25 30

Gin Asp lie Leu Met Asp Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala 35 40 45

Phe Asn Arg Ala Val Lys Ser Leu Gin Asn Ala Ser Ala lie Glu Ser 50 55 60

He Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro 65 70 75 80

Thr Arg His Pro lie His lie Lys Asp Gly Asp Trp Asn Glu Phe Arg 85 90 95

Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gin Ala Gin 100 105 110

Gin Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 115 120 125 lie Ser Thr He Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 130 135 140

Pro Asn Met Ala Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Phe 145 150 155 160

Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser Phe 165 170 175

Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro Ser Gly 180 185 190

Gly Ser Gly Gly Ser Gin Ser Phe Leu Leu Lys Ser Leu Glu Gin Val 195 200 205

Arg Lys lie Gin Gly Asp Gly Ala Ala Leu Gin Glu Lys Leu Cys Ala 210 215 220

Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His Ser 225 230 235 240

Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gin Ala Leu 245 250 255

Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser Gly Leu Phe Leu Tyr 260 265 270

Gin Gly Leu Leu Gin Ala Leu Glu Gly lie Ser Pro Glu Leu Gly Pro 275 280 285

Thr Leu Asp Thr Leu Gin Leu Asp Val Ala Asp Phe Ala Thr Thr lie 290 295 300

Trp Gin Gin Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gin Pro 305 310 315 (2)序列編號NO: 506資料： (i)序列特性： (A)長度：322胺基酸 O:\92\92747.DOC 267- 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述··序列編號NO: 506

Met Ala Asn Cys Ser Asn Met lie Asp Glu lie lie Thr His Leu Lys 15 10 15

Gin Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp 20 25 30

Gin Asp lie Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala 35 40 45

Phe Asn Arg Ala Val Lys Ser Leu Gin Asn Ala Ser Ala lie Glu Ser 50 55 60 lie Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro 65 70 75 80

Thr Arg His Pro lie lie lie Arg Asp Gly Asp Trp Asn Glu Phe Arg 85 90 95

Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gin Ala Gin 100 105 110

Pro Asn Met Ala Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Phe 145 150 155 160

Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser Phe 165 170 175

Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro Thr Pro 180 185 190

Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser Phe Leu Leu Lys Ser Leu 195 200 205

Glu Gin Val Arg Lys He Gin Gly Asp Gly Ala Ala Leu Gin Glu Lys 210 215 220

Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu 225 230 235 240

Gly His Ser Leu Gly He Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser 245 250 255

Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser Gly Leu 260 265 270

Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie Ser Pro Glu 275 280 285

Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala Asp Phe Ala 290 295 300

Thr Thr He Trp Gin Gin Met Glu Glu Leu Gly Met Ala Pro Ala Leu 305 310 315 320

Gin Pro (2)序列編號NO: 507資料： (i)序列特性： (A)長度：3 19胺基酸 O:\92\92747.DOC -268- (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 507

Met Ala Asn Cys Ser Asn Met lie Asp Glu lie lie Thr His Leu Lys 15 10 15

Gin Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp 20 25 30

Gin Asp lie Leu Met Glu Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala 35 40 45

Thr Arg His Pro lie lie He Arg Asp Gly Asp Trp Asn Glu Phe Arg 85 90 95

Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gin Ala Gin 100 105 110

Pro Asn Met Ala Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Phe 145 150 155 160

Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser Phe 165 170 175

Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro Ser Gly 180 185 190

Gly Ser Gly Gly Ser Gin Ser Phe Leu Leu Lys Ser Leu Glu Gin Val 195 200 205

Arg Lys lie Gin Gly Asp Gly Ala Ala Leu Gin Glu Lys Leu Cys Ala 210 215 220

Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His Ser 225 230 235 240

Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gin Ala Leu 245 250 255

Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser Gly Leu Phe Leu Tyr 260 265 270

Gin Gly Leu Leu Gin Ala Leu Glu Gly lie Ser Pro Glu Leu Gly Pro 275 280 285

Thr Leu Asp Thr Leu Gin Leu Asp Val Ala Asp Phe Ala Thr Thr lie 290 295 300

Trp Gin Gin Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gin Pro 305 310 315 (2)序列編號NO: 508資料： (i)序列特性： (A)長度：322胺基酸 269

O:\92\92747.DOC 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 508

Met Ala Asn Cys Ser Asn Met He Asp Glu lie He Thr His Leu Lys 15 10 15

Gin Pro Pro Leu Pro Leu Leu Asp Phe Asn Asn Leu Asn Gly Glu Asp 20 25 30

Gin Asp lie Leu Met Asp Asn Asn Leu Arg Arg Pro Asn Leu Glu Ala 35 40 45

Phe Asn Arg Ala Val Lys Ser Leu Gin Asn Ala Ser Ala He Glu Ser 50 55 60 lie Leu Lys Asn Leu Leu Pro Cys Leu Pro Leu Ala Thr Ala Ala Pro 65 70 75 80

Thr Arg His Pro He His He Lys Asp Gly Asp Trp Asn Glu Phe Arg 85 90 95

Arg Lys Leu Thr Phe Tyr Leu Lys Thr Leu Glu Asn Ala Gin Ala Gin 100 105 110

Gin Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 115 120 125

He Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 130 135 140

Pro Asn Met Ala Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Phe 145 150 155 160

Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser Phe 165 170 175

Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro Thr Pro 180 185 190

Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser Phe Leu Leu Lys Ser Leu 195 200 205

Glu Gin Val Arg Lys He Gin Gly Asp Gly Ala Ala Leu Gin Glu Lys 210 215 220

Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu 225 230 235 240

Gly His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser 245 250 255

Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser Gly Leu 260 265 270

Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie Ser Pro Glu 275 280 285

Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala Asp Phe Ala 290 295 300

Thr Thr lie Trp Gin Gin Met Glu Glu Leu Gly Met Ala Pro Ala Leu 305 310 315 320

Gin Pro (2)序列編號NO·· 509資料： (i)序列特性： (A)長度：306胺基酸 O:\92\92747.DOC -270- 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO.· 509

Ala Asn Cys Ser He Met He Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30

Ser He Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45

Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly He Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Glu Val His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala Val 145 150 155 160

Asp Phe Ser Leu Gly Glu Trp Lys Thr Gin Met Glu Glu Thr Lys Ala 165 170 175

Gin Asp lie Leu Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala 180 185 190

Ala Arg Gly Gin Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gin 195 200 205

Leu Ser Gly Gin Val Arg Leu Leu Leu Gly Ala Leu Gin Ser Leu Leu 210 215 220

Gly Thr Gin Leu Pro Pro Gin Gly Arg Thr Thr Ala His Lys Asp Pro 225 230 235 240

Asn Ala lie Phe Leu Ser Phe Gin His Leu Leu Arg Gly Lys Val Arg 245 250 255

Phe Leu Met Leu Val Gly Gly Ser Thr Leu Cys Val Arg Glu Phe Gly 260 265 270

Gly Asn Met Ala Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu 275 280 285

Ser Lys Leu Leu Arg Asp Ser His Val Leu His Ser Arg Leu Ser Gin 290 295 300

Cys Pro 305 (2)序列編號NO: 510資料： (i)序列特性： (A)長度：306胺基酸 O:\92\92747.DOC 271- 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 510

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30

Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45

Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr He Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Leu Pro Thr Pro Val Leu Leu Pro Ala Val Asp Phe Ser Leu 145 150 155 160

Gly Glu Trp Lys Thr Gin Met Glu Glu Thr Lys Ala Gin Asp lie Leu 165 170 175

Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala Ala Arg Gly Gin 180 185 190

Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gin Leu Ser Gly Gin 195 200 205

Val Arg Leu Leu Leu Gly Ala Leu Gin Ser Leu Leu Gly Thr Gin Leu 210 215 220

Pro Pro Gin Gly Arg Thr Thr Ala His Lys Asp Pro Asn Ala lie Phe 225 230 235 240

Leu Ser Phe Gin His Leu Leu Arg Gly Lys Val Arg Phe Leu Met Leu 245 250 255

Val Gly Gly Ser Thr Leu Cys Val Arg Glu Phe Gly Gly Asn Met Ala 260 265 270

Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser Lys Leu Leu 275 280 285

Arg Asp Ser His Val Leu His Ser Arg Leu Ser Gin Cys Pro Glu Val 290 295 300

His Pro 305 (2)序列編號NO: 511資料： (i)序列特性： (A)長度：306胺基酸 O:\92\92747.DOC 272- 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 511

Ala Asn Cys Ser lie Met He Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30

Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45

Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly He Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr He Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Val Leu Leu Pro Ala Val Asp Phe Ser Leu Gly Glu Trp Lys 145 150 155 160

Thr Gin Met Glu Glu Thr Lys Ala Gin Asp lie Leu Gly Ala Val Thr 165 170 175

Leu Leu Leu Glu Gly Val Met Ala Ala Arg Gly Gin Leu Gly Pro Thr 180 185 190

Cys Leu Ser Ser Leu Leu Gly Gin Leu Ser Gly Gin Val Arg Leu Leu 195 200 205

Leu Gly Ala Leu Gin Ser Leu Leu Gly Thr Gin Leu Pro Pro Gin Gly 210 215 220

Arg Thr Thr Ala His Lys Asp Pro Asn Ala lie Phe Leu Ser Phe Gin 225 230 235 240

His Leu Leu Arg Gly Lys Val Arg Phe Leu Met Leu Val Gly Gly Ser 245 250 255

Thr Leu Cys Val Arg Glu Phe Gly Gly Asn Met Ala Ser Pro Ala Pro 260 265 270

Pro Ala Cys Asp Leu Arg Val Leu Ser Lys Leu Leu Arg Asp Ser His 275 280 285

Val Leu His Ser Arg Leu Ser Gin Cys Pro Glu Val His Pro Leu Pro 290 295 300

Thr Pro 305 (2)序列編號NO: 512資料： (i)序列特性： (A)長度：306胺基酸 O:\92\92747.DOC 273- 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 512

Ala Asn Cys Ser lie Met lie Asp Glu lie He His His Leu Lys Arg 15 10 15

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30

Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45

Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly He Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Val Asp Phe Ser Leu Gly Glu Trp Lys Thr Gin Met Glu 145 150 155 160

Glu Thr Lys Ala Gin Asp lie Leu Gly Ala Val Thr Leu Leu Leu Glu 165 170 175

Gly Val Met Ala Ala Arg Gly Gin Leu Gly Pro Thr Cys Leu Ser Ser 180 185 190

Leu Leu Gly Gin Leu Ser Gly Gin Val Arg Leu Leu Leu Gly Ala Leu 195 200 205

Gin Ser Leu Leu Gly Thr Gin Leu Pro Pro Gin Gly Arg Thr Thr Ala 210 215 220

His Lys Asp Pro Asn Ala lie Phe Leu Ser Phe Gin His Leu Leu Arg 225 230 235 240

Gly Lys Val Arg Phe Leu Met Leu Val Gly Gly Ser Thr Leu Cys Val 245 250 255

Arg Glu Phe Gly Gly Asn Met Ala Ser Pro Ala Pro Pro Ala Cys Asp 260 265 270

Leu Arg Val Leu Ser Lys Leu Leu Arg Asp Ser His Val Leu His Ser 275 280 285

Arg Leu Ser Gin Cys Pro Glu Val His Pro Leu Pro Thr Pro Val Leu 290 295 300

Leu Pro 305 (2)序列編號NO: 513資料： (i)序列特性： (A)長度：306胺基酸 O:\92\92747.DOC 274- (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 513

Ala Asn Cys Ser lie Met He Asp Glu He lie His His Leu Lys Arg 15 10 15

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30

Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45

Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro He He lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Asp Phe Ser Leu Gly Glu Trp Lys Thr Gin Met Glu Glu Thr 145 150 155 160

Lys Ala Gin Asp He Leu Gly Ala Val Thr Leu Leu Leu Glu Gly Val 165 170 175

Met Ala Ala Arg Gly Gin Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu 180 185 190

Gly Gin Leu Ser Gly Gin Val Arg Leu Leu Leu Gly Ala Leu Gin Ser 195 200 205

Leu Leu Gly Thr Gin Leu Pro Pro Gin Gly Arg Thr Thr Ala His Lys 210 215 220

Asp Pro Asn Ala lie Phe Leu Ser Phe Gin His Leu Leu Arg Gly Lys 225 230 235 240

Val Arg Phe Leu Met Leu Val Gly Gly Ser Thr Leu Cys Val Arg Glu 245 250 255

Phe Gly Gly Asn Met Ala Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg 260 265 270

Val Leu Ser Lys Leu Leu Arg Asp Ser His Val Leu His Ser Arg Leu 275 280 285

Ser Gin Cys Pro Glu Val His Pro Leu Pro Thr Pro Val Leu Leu Pro 290 295 300

Ala Val 305 (2)序列編號NO: 514資料： (i)序列特性： (A)長度：306胺基酸 -275-

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Ala Asn Cys Ser lie Met lie Asp Glu lie He His His Leu Lys Arg 15 10 15

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30

Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45

Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie He Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Gly Glu Trp Lys Thr Gin Met Glu Glu Thr Lys Ala Gin Asp 145 150 155 160 lie Leu Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala Ala Arg 165 170 175

Gly Gin Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gin Leu Ser 180 185 190

Gly Gin Val Arg Leu Leu Leu Gly Ala Leu Gin Ser Leu Leu Gly Thr 195 200 205

Gin Leu Pro Pro Gin Gly Arg Thr Thr Ala His Lys Asp Pro Asn Ala 210 215 220 lie Phe Leu Ser Phe Gin His Leu Leu Arg Gly Lys Val Arg Phe Leu 225 230 235 240

Met Leu Val Gly Gly Ser Thr Leu Cys Val Arg Glu Phe Gly Gly Asn 245 250 255

Met Ala Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser Lys 260 265 270

Leu Leu Arg Asp Ser His Val Leu His Ser Arg Leu Ser Gin Cys Pro 275 280 285

Glu Val His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala Val Asp Phe 290 295 300

Ser Leu 305 (2)序列編號NO: 515資料： (i)序列特性： (A)長度：306胺基酸 O:\92\92747.DOC 276- 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (Π)分子類型：無 (xi)序列描述：序列編號NO: 515

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30

Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45

Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro He He lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gin Leu Ser Gly 145 150 155 160

Gin Val Arg Leu Leu Leu Gly Ala Leu Gin Ser Leu Leu Gly Thr Gin 165 170 175

Leu Pro Pro Gin Gly Arg Thr Thr Ala His Lys Asp Pro Asn Ala lie 180 185 190

Phe Leu Ser Phe Gin His Leu Leu Arg Gly Lys Val Arg Phe Leu Met 195 200 205

Leu Val Gly Gly Ser Thr Leu Cys Val Arg Glu Phe Gly Gly Asn Met 210 215 220

Ala Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser Lys Leu 225 230 235 240

Leu Arg Asp Ser His Val Leu His Ser Arg Leu Ser Gin Cys Pro Glu 245 250 255

Val His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala Val Asp Phe Ser 260 265 270

Leu Gly Glu Trp Lys Thr Gin Met Glu Glu Thr Lys Ala Gin Asp lie 275 280 285

Leu Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala Ala Arg Gly 290 295 300

Gin Leu 305 (2)序列編號NO: 516資料： (i)序列特性： (A)長度：306胺基酸 O:\92\92747.DOC 277- 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO.· 516

Ala Asn Cys Ser He Met lie Asp Glu lie He His His Leu Lys Arg 15 10 15

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30

Ser He Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45

Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie He He Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Gly Thr Gin Leu Pro Pro Gin Gly Arg Thr Thr Ala His Lys 145 150 155 160

Asp Pro Asn Ala He Phe Leu Ser Phe Gin His Leu Leu Arg Gly Lys 165 170 175

Val Arg Phe Leu Met Leu Val Gly Gly Ser Thr Leu Cys Val Arg Glu 180 185 190

Phe Gly Gly Asn Met Ala Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg 195 200 205

Val Leu Ser Lys Leu Leu Arg Asp Ser His Val Leu His Ser Arg Leu 210 215 220

Ser Gin Cys Pro Glu Val His Pro Leu Pro Thr Pro Val Leu Leu Pro 225 230 235 240

Ala Val Asp Phe Ser Leu Gly Glu Trp Lys Thr Gin Met Glu Glu Thr 245 250 255

Lys Ala Gin Asp lie Leu Gly Ala Val Thr Leu Leu Leu Glu Gly Val 260 265 270

Met Ala Ala Arg Gly Gin Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu 275 280 285

Gly Gin Leu Ser Gly Gin Val Arg Leu Leu Leu Gly Ala Leu Gin Ser 290 295 300

Leu Leu 305 (2)序列編號NO: 517資料： (i)序列特性： (A)長度：306胺基酸 O:\92\92747.DOC 278- 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 517

Ala Asn Cys Ser lie Met lie Asp Glu lie He His His Leu Lys Arg 15 10 15

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30

Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45

Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro He lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Gly Arg Thr Thr Ala His Lys Asp Pro Asn Ala lie Phe Leu 145 150 155 160

Ser Phe Gin His Leu Leu Arg Gly Lys Val Arg Phe Leu Met Leu Val 165 170 175

Gly Gly Ser Thr Leu Cys Val Arg Glu Phe Gly Gly Asn Met Ala Ser 180 185 190

Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser Lys Leu Leu Arg 195 200 205

Asp Ser His Val Leu His Ser Arg Leu Ser Gin Cys Pro Glu Val His 210 215 220

Pro Leu Pro Thr Pro Val Leu Leu Pro Ala Val Asp Phe Ser Leu Gly 225 230 235 240

Glu Trp Lys Thr Gin Met Glu Glu Thr Lys Ala Gin Asp He Leu Gly 245 250 255

Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala Ala Arg Gly Gin Leu 260 265 270

Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gin Leu Ser Gly Gin Val 275 280 285

Arg Leu Leu Leu Gly Ala Leu Gin Ser Leu Leu Gly Thr Gin Leu Pro 290 295 300

Pro Gin 305 (2)序列編號NO: 518資料： (i)序列特性： (A)長度：306胺基酸 O:\92\92747.DOC 279- 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 518

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30

Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45

Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr He Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala His Lys Asp Pro Asn Ala lie Phe Leu Ser Phe Gin His 145 150 155 160

Leu Leu Arg Gly Lys Val Arg Phe Leu Met Leu Val Gly Gly Ser Thr 165 170 175

Leu Cys Val Arg Glu Phe Gly Gly Asn Met Ala Ser Pro Ala Pro Pro 180 185 190

Ala Cys Asp Leu Arg Val Leu Ser Lys Leu Leu Arg Asp Ser His Val 195 200 205

Leu His Ser Arg Leu Ser Gin Cys Pro Glu Val His Pro Leu Pro Thr 210 215 220

Pro Val Leu Leu Pro Ala Val Asp Phe Ser Leu Gly Glu Trp Lys Thr 225 230 235 240

Gin Met Glu Glu Thr Lys Ala Gin Asp He Leu Gly Ala Val Thr Leu 245 250 255

Leu Leu Glu Gly Val Met Ala Ala Arg Gly Gin Leu Gly Pro Thr Cys 260 265 270

Leu Ser Ser Leu Leu Gly Gin Leu Ser Gly Gin Val Arg Leu Leu Leu 275 280 285

Gly Ala Leu Gin Ser Leu Leu Gly Thr Gin Leu Pro Pro Gin Gly Arg 290 295 300

Thr Thr 305 (2)序列編號NO: 519資料： (i)序列特性· (A)長度：306胺基酸 O:\92\92747.DOC -280- 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 519

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30

Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45

Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala He 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Asp Pro Asn Ala lie Phe Leu Ser Phe Gin His Leu Leu Arg 145 150 155 160

Gly Lys Val Arg Phe Leu Met Leu Val Gly Gly Ser Thr Leu Cys Val 165 170 175

Arg Glu Phe Gly Gly Asn Met Ala Ser Pro Ala Pro Pro Ala Cys Asp 180 185 190

Leu Arg Val Leu Ser Lys Leu Leu Arg Asp Ser His Val Leu His Ser 195 200 205

Arg Leu Ser Gin Cys Pro Glu Val His Pro Leu Pro Thr Pro Val Leu 210 215 220

Leu Pro Ala Val Asp Phe Ser Leu Gly Glu Trp Lys Thr Gin Met Glu 225 230 235 240

Glu Thr Lys Ala Gin Asp lie Leu Gly Ala Val Thr Leu Leu Leu Glu 245 250 255

Gly Val Met Ala Ala Arg Gly Gin Leu Gly Pro Thr Cys Leu Ser Ser 260 265 270

Leu Leu Gly Gin Leu Ser Gly Gin Val Arg Leu Leu Leu Gly Ala Leu 275 280 285

Gin Ser Leu Leu Gly Thr Gin Leu Pro Pro Gin Gly Arg Thr Thr Ala 290 295 300

His Lys 305 (2)序列編號NO: 520資料： (i)序列特性： (A)長度：306胺基酸 281-

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Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30

Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45

Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly He Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie He lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala lie Phe Leu Ser Phe Gin His Leu Leu Arg Gly Lys Val 145 150 155 160

Arg Phe Leu Met Leu Val Gly Gly Ser Thr Leu Cys Val Arg Glu Phe 165 170 175

Gly Gly Asn Met Ala Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val 180 185 190

Leu Ser Lys Leu Leu Arg Asp Ser His Val Leu His Ser Arg Leu Ser 195 200 205

Gin Cys Pro Glu Val His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala 210 215 220

Val Asp Phe Ser Leu Gly Glu Trp Lys Thr Gin Met Glu Glu Thr Lys 225 230 235 240

Ala Gin Asp lie Leu Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met 245 250 255

Ala Ala Arg Gly Gin Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly 260 265 270

Gin Leu Ser Gly Gin Val Arg Leu Leu Leu Gly Ala Leu Gin Ser Leu 275 280 285

Leu Gly Thr Gin Leu Pro Pro Gin Gly Arg Thr Thr Ala His Lys Asp 290 295 300

Pro Asn 305 (2)序列編號NO: 521資料： (i)序列特性： (A)長度：305胺基酸 O:\92\92747.DOC 282- 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 521

Ala Asn Cys Ser lie Met lie Asp Glu He lie His His Leu Lys Arg 15 10 15

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30

Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45

Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro He He lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Glu Val His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala Val 145 150 155 160

Asp Phe Ser Leu Gly Glu Trp Lys Thr Gin Met Glu Glu Thr Lys Ala 165 170 175

Gin Asp He Leu Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala 180 185 190

Ala Arg Gly Gin Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gin 195 200 205

Leu Ser Gly Gin Val Arg Leu Leu Leu Gly Ala Leu Gin Ser Leu Leu 210 215 220

Gly Thr Gin Leu Pro Pro Gin Gly Arg Thr Thr Ala His Lys Asp Pro 225 230 235 240

Asn Ala He Phe Leu Ser Phe Gin His Leu Leu Arg Gly Lys Val Arg 245 250 255

Phe Leu Met Leu Val Gly Gly Ser Thr Leu Cys Val Arg Glu Phe Gly 260 265 270

Asn Met Ala Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser 275 280 285

Lys Leu Leu Arg Asp Ser His Val Leu His Ser Arg Leu Ser Gin Cys 290 295 300

Pro 305 (2)序列編號NO: 522資料： (i)序列特性： (A)長度：305胺基酸 O:\92\92747.DOC -283- 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 522

Ala Asn Cys Ser lie Met He Asp Glu lie lie His His Leu Lys Arg 1 5 10 15

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30

Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45

Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro He lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Leu Pro Thr Pro Val Leu Leu Pro Ala Val Asp Phe Ser Leu 145 150 155 160

Gly Glu Trp Lys Thr Gin Met Glu Glu Thr Lys Ala Gin Asp lie Leu 165 170 175

Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala Ala Arg Gly Gin 180 185 190

Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gin Leu Ser Gly Gin 195 200 205

Val Arg Leu Leu Leu Gly Ala Leu Gin Ser Leu Leu Gly Thr Gin Leu 210 215 220

Pro Pro Gin Gly Arg Thr Thr Ala His Lys Asp Pro Asn Ala lie Phe 225 230 235 240

Leu Ser Phe Gin His Leu Leu Arg Gly Lys Val Arg Phe Leu Met Leu 245 250 255

Val Gly Gly Ser Thr Leu Cys Val Arg Glu Phe Gly Asn Met Ala Ser 260 265 270

Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser Lys Leu Leu Arg 275 280 285

Asp Ser His Val Leu His Ser Arg Leu Ser Gin Cys Pro Glu Val His 290 295 300

Pro 305 (2)序列編號NO: 523資料： (i)序列特性： (A)長度：305胺基酸 O:\92\92747.DOC 284- 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 523

Ala Asn Cys Ser He Met lie Asp Glu lie He His His Leu Lys Arg 15 10 15

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30

Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45

Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie He lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Val Leu Leu Pro Ala Val Asp Phe Ser Leu Gly Glu Trp Lys 145 150 155 160

Thr Gin Met Glu Glu Thr Lys Ala Gin Asp lie Leu Gly Ala Val Thr 165 170 175

Leu Leu Leu Glu Gly Val Met Ala Ala Arg Gly Gin Leu Gly Pro Thr 180 185 190

Cys Leu Ser Ser Leu Leu Gly Gin Leu Ser Gly Gin Val Arg Leu Leu 195 200 205

Leu Gly Ala Leu Gin Ser Leu Leu Gly Thr Gin Leu Pro Pro Gin Gly 210 215 220

Arg Thr Thr Ala His Lys Asp Pro Asn Ala He Phe Leu Ser Phe Gin 225 230 235 240

His Leu Leu Arg Gly Lys Val Arg Phe Leu Met Leu Val Gly Gly Ser 245 250 255

Thr Leu Cys Val Arg Glu Phe Gly Asn Met Ala Ser Pro Ala Pro Pro 260 265 270

Ala Cys Asp Leu Arg Val Leu Ser Lys Leu Leu Arg Asp Ser His Val 275 280 285

Leu His Ser Arg Leu Ser Gin Cys Pro Glu Val His Pro Leu Pro Thr 290 295 300

Pro 305 (2)序列編號NO: 524資料： (i)序列特性： (A)長度：305胺基酸 O:\92\92747.DOC 285 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 524

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30

Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45

Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro He lie He Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Val Asp Phe Ser Leu Gly Glu Trp Lys Thr Gin Met Glu 145 150 155 160

Glu Thr Lys Ala Gin Asp lie Leu Gly Ala Val Thr Leu Leu Leu Glu 165 170 175

Gly Val Met Ala Ala Arg Gly Gin Leu Gly Pro Thr Cys Leu Ser Ser 180 185 190

Leu Leu Gly Gin Leu Ser Gly Gin Val Arg Leu Leu Leu Gly Ala Leu 195 200 205

Gin Ser Leu Leu Gly Thr Gin Leu Pro Pro Gin Gly Arg Thr Thr Ala 210 215 220

His Lys Asp Pro Asn Ala lie Phe Leu Ser Phe Gin His Leu Leu Arg 225 230 235 240

Gly Lys Val Arg Phe Leu Met Leu Val Gly Gly Ser Thr Leu Cys Val 245 250 255

Arg Glu Phe Gly Asn Met Ala Ser Pro Ala Pro Pro Ala Cys Asp Leu 260 265 270

Arg Val Leu Ser Lys Leu Leu Arg Asp Ser His Val Leu His Ser Arg 275 280 285

Leu Ser Gin Cys Pro Glu Val His Pro Leu Pro Thr Pro Val Leu Leu 290 295 300

Pro 305 (2)序列編號NO: 525資料： (i)序列特性： (A)長度：305胺基酸 O:\92V92747.DOC 286- 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 525

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30

Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45

Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro He lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Asp Phe Ser Leu Gly Glu Trp Lys Thr Gin Met Glu Glu Thr 145 150 155 160

Lys Ala Gin Asp lie Leu Gly Ala Val Thr Leu Leu Leu Glu Gly Val 165 170 175

Met Ala Ala Arg Gly Gin Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu 180 185 190

Gly Gin Leu Ser Gly Gin Val Arg Leu Leu Leu Gly Ala Leu Gin Ser 195 200 205

Leu Leu Gly Thr Gin Leu Pro Pro Gin Gly Arg Thr Thr Ala His Lys 210 215 220

Asp Pro Asn Ala lie Phe Leu Ser Phe Gin His Leu Leu Arg Gly Lys 225 230 235 240

Val Arg Phe Leu Met Leu Val Gly Gly Ser Thr Leu Cys Val Arg Glu 245 250 255

Phe Gly Asn Met Ala Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val 260 265 270

Leu Ser Lys Leu Leu Arg Asp Ser His Val Leu His Ser Arg Leu Ser 275 280 285

Gin Cys Pro Glu Val His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala 290 295 300

Val 305 (2)序列編號NO: 526資料： (i)序列特性： (A)長度：305胺基酸 O:\92\92747.DOC 287- 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 526

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30

Ser He Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45

Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly He Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro He lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He 115 120 125

Ser Thr He Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Gly Gin Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gin Leu Ser 180 185 190

Gly Gin Val Arg Leu Leu Leu Gly Ala Leu Gin Ser Leu Leu Gly Thr 195 200 205

Met Leu Val Gly Gly Ser Thr Leu Cys Val Arg Glu Phe Gly Asn Met 245 250 255

Ala Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser Lys Leu 260 265 270

Leu Arg Asp Ser His Val Leu His Ser Arg Leu Ser Gin Cys Pro Glu 275 280 285

Val His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala Val Asp Phe Ser 290 295 300

Leu 305 (2)序列編號NO: 527資料： (i)序列特性： (A)長度：305胺基酸 O:\92\92747.DOC 288- 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 527

Ala Asn Cys Ser He Met He Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30

Ser He Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45

Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gin Leu Ser Gly 145 150 155 160

Gin Val Arg Leu Leu Leu Gly Ala Leu Gin Ser Leu Leu Gly Thr Gin 165 170 175

Leu Pro Pro Gin Gly Arg Thr Thr Ala His Lys Asp Pro Asn Ala lie 180 185 190

Phe Leu Ser Phe Gin His Leu Leu Arg Gly Lys Val Arg Phe Leu Met 195 200 205

Leu Val Gly Gly Ser Thr Leu Cys Val Arg Glu Phe Gly Asn Met Ala 210 215 220

Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser Lys Leu Leu 225 230 235 240

Arg Asp Ser His Val Leu His Ser Arg Leu Ser Gin Cys Pro Glu Val 245 250 255

His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala Val Asp Phe Ser Leu 260 265 270

Gly Glu Trp Lys Thr Gin Met Glu Glu Thr Lys Ala Gin Asp lie Leu 275 280 285

Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala Ala Arg Gly Gin 290 295 300

Leu 305 (2)序列編號NO: 528資料： (i)序列特性： (A)長度：305胺基酸 O:\92\92747.DOC 289- 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 528

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30

Ser He Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45

Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr He Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Gly Thr Gin Leu Pro Pro Gin Gly Arg Thr Thr Ala His Lys 145 150 155 160

Asp Pro Asn Ala He Phe Leu Ser Phe Gin His Leu Leu Arg Gly Lys 165 170 175

Val Arg Phe Leu Met Leu Val Gly Gly Ser Thr Leu Cys Val Arg Glu 180 185 190

Phe Gly Asn Met Ala Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val 195 200 205

Leu Ser Lys Leu Leu Arg Asp Ser His Val Leu His Ser Arg Leu Ser 210 215 220

Gin Cys Pro Glu Val His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala 225 230 235 240

Val Asp Phe Ser Leu Gly Glu Trp Lys Thr Gin Met Glu Glu Thr Lys 245 250 255

Ala Gin Asp He Leu Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met 260 265 270

Ala Ala Arg Gly Gin Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly 275 280 285

Gin Leu Ser Gly Gin Val Arg Leu Leu Leu Gly Ala Leu Gin Ser Leu 290 295 300

Leu 305 (2)序列編號NO: 529資料： (i)序列特性： (A)長度：305胺基酸 O:\92\92747.DOC -290- 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 529

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30

Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45

Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly He Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr He Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Gly Arg Thr Thr Ala His Lys Asp Pro Asn Ala lie Phe Leu 145 150 155 160

Ser Phe Gin His Leu Leu Arg Gly Lys Val Arg Phe Leu Met Leu Val 165 170 175

Gly Gly Ser Thr Leu Cys Val Arg Glu Phe Gly Asn Met Ala Ser Pro 180 185 190

Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser Lys Leu Leu Arg Asp 195 200 205

Ser His Val Leu His Ser Arg Leu Ser Gin Cys Pro Glu Val His Pro 210 215 220

Leu Pro Thr Pro Val Leu Leu Pro Ala Val Asp Phe Ser Leu Gly Glu 225 230 235 240

Trp Lys Thr Gin Met Glu Glu Thr Lys Ala Gin Asp lie Leu Gly Ala 245 250 255

Val Thr Leu Leu Leu Glu Gly Val Met Ala Ala Arg Gly Gin Leu Gly 260 265 270

Pro Thr Cys Leu Ser Ser Leu Leu Gly Gin Leu Ser Gly Gin Val Arg 275 280 285

Leu Leu Leu Gly Ala Leu Gin Ser Leu Leu Gly Thr Gin Leu Pro Pro 290 295 300

Gin 305 (2)序列編號NO: 530資料： (i)序列特性： (A)長度：305胺基酸 O:\92\92747.DOC -291 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO·. 530

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30

Ser He Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45

Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala His Lys Asp Pro Asn Ala lie Phe Leu Ser Phe Gin His 145 150 155 160

Leu Leu Arg Gly Lys Val Arg Phe Leu Met Leu Val Gly Gly Ser Thr 165 170 175

Leu Cys Val Arg Glu Phe Gly Asn Met Ala Ser Pro Ala Pro Pro Ala 180 185 190

Cys Asp Leu Arg Val Leu Ser Lys Leu Leu Arg Asp Ser His Val Leu 195 200 205

His Ser Arg Leu Ser Gin Cys Pro Glu Val His Pro Leu Pro Thr Pro 210 215 220

Val Leu Leu Pro Ala Val Asp Phe Ser Leu Gly Glu Trp Lys Thr Gin 225 230 235 240

Met Glu Glu Thr Lys Ala Gin Asp lie Leu Gly Ala Val Thr Leu Leu 245 250 255

Leu Glu Gly Val Met Ala Ala Arg Gly Gin Leu Gly Pro Thr Cys Leu 260 265 270

Ser Ser Leu Leu Gly Gin Leu Ser Gly Gin Val Arg Leu Leu Leu Gly 275 280 285

Ala Leu Gin Ser Leu Leu Gly Thr Gin Leu Pro Pro Gin Gly Arg Thr 290 295 300

Thr 305 (2)序列編號NO: 531資料： (i)序列特性： (A)長度：305胺基酸 O:\92\92747.DOC 292- 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (Π)分子類型：無 (xi)序列描述：序列編號NO: 531

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30

Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45

Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Asp Pro Asn Ala lie Phe Leu Ser Phe Gin His Leu Leu Arg 145 150 155 160

Gly Lys Val Arg Phe Leu Met Leu Val Gly Gly Ser Thr Leu Cys Val 165 170 175

Arg Glu Phe Gly Asn Met Ala Ser Pro Ala Pro Pro Ala Cys Asp Leu 180 185 190

Arg Val Leu Ser Lys Leu Leu Arg Asp Ser His Val Leu His Ser Arg 195 200 205

Leu Ser Gin Cys Pro Glu Val His Pro Leu Pro Thr Pro Val Leu Leu 210 215 220

Pro Ala Val Asp Phe Ser Leu Gly Glu Trp Lys Thr Gin Met Glu Glu 225 230 235 240

Thr Lys Ala Gin Asp lie Leu Gly Ala Val Thr Leu Leu Leu Glu Gly 245 250 255

Val Met Ala Ala Arg Gly Gin Leu Gly Pro Thr Cys Leu Ser Ser Leu 260 265 270

Leu Gly Gin Leu Ser Gly Gin Val Arg Leu Leu Leu Gly Ala Leu Gin 275 280 285

Ser Leu Leu Gly Thr Gin Leu Pro Pro Gin Gly Arg Thr Thr Ala His 290 295 300

Lys 305 (2)序列編號NO: 532資料： (i)序列特性： (A)長度：305胺基酸 O:\92\92747.DOC 293- 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 532

Ala Asn Cys Ser He Met He Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30

Ser He Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45

Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala lie Phe Leu Ser Phe Gin His Leu Leu Arg Gly Lys Val 145 150 155 160

Arg Phe Leu Met Leu Val Gly Gly Ser Thr Leu Cys Val Arg Glu Phe 165 170 175

Gly Asn Met Ala Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu 180 185 190

Ser Lys Leu Leu Arg Asp Ser His Val Leu His Ser Arg Leu Ser Gin 195 200 205

Cys Pro Glu Val His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala Val 210 215 220

Asp Phe Ser Leu Gly Glu Trp Lys Thr Gin Met Glu Glu Thr Lys Ala 225 230 235. 240

Gin Asp lie Leu Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala 245 250 255

Ala Arg Gly Gin Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gin 260 265 270

Leu Ser Gly Gin Val Arg Leu Leu Leu Gly Ala Leu Gin Ser Leu Leu 275 280 285

Gly Thr Gin Leu Pro Pro Gin Gly Arg Thr Thr Ala His Lys Asp Pro 290 295 300

Asn 305 (2)序列編號NO·. 533資料： (i)序列特性： (A)長度：309胺基酸 O:\92\92747.DOC' 294- 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 533

Ala Asn Cys Ser lie Met lie Asp Glu He lie His His Leu Lys Arg 15 10 15

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30

Ssr He Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45

Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly He Glu Ala He 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie He Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Glu Val His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala Val 145 150 155 160

Asp Phe Ser Leu Gly Glu Trp Lys Thr Gin Met Glu Glu Thr Lys Ala 165 170 175

Gin Asp lie Leu Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala 180 185 190

Ala Arg Gly Gin Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gin 195 200 205

Leu Ser Gly Gin Val Arg Leu Leu Leu Gly Ala Leu Gin Ser Leu Leu 210 215 220

Gly Thr Gin Leu Pro Pro Gin Gly Arg Thr Thr Ala His Lys Asp Pro 225 230 235 240

Asn Ala He Phe Leu Ser Phe Gin His Leu Leu Arg Gly Lys Val Arg 245 250 255

Phe Leu Met Leu Val Gly Gly Ser Thr Leu Cys Val Arg Glu Phe Gly 260 265 270

Gly Asn Gly Gly Asn Met Ala Ser Pro Ala Pro Pro Ala Cys Asp Leu 275 280 285

Arg Val Leu Ser Lys Leu Leu Arg Asp Ser His Val Leu His Ser Arg 290 295 300

Leu Ser Gin Cys Pro 305 (2)序列編號NO: 534資料： (i)序列特性： (A)長度：309胺基酸 O:\92\92747.DOC 295- 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (Π)分子類型：無 (xi)序列描述：序列編號NO: 534

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30

Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45

Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie He Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr He Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Leu Pro Thr Pro Val Leu Leu Pro Ala Val Asp Phe Ser Leu 145 150 155 160

Gly Glu Trp Lys Thr Gin Met Glu Glu Thr Lys Ala Gin Asp lie Leu 165 170 175

Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala Ala Arg Gly Gin 180 185 190

Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gin Leu Ser Gly Gin 195 200 205

Val Arg Leu Leu Leu Gly Ala Leu Gin Ser Leu Leu Gly Thr Gin Leu 210 215 220

Pro Pro Gin Gly Arg Thr Thr Ala His Lys Asp Pro Asn Ala He Phe 225 230 235 240

Leu Ser Phe Gin His Leu Leu Arg Gly Lys Val Arg Phe Leu Met Leu 245 250 255

Val Gly Gly Ser Thr Leu Cys Val Arg Glu Phe Gly Gly Asn Gly Gly 260 265 270

Asn Met Ala Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser 275 280 285

Lys Leu Leu Arg Asp Ser His Val Leu His Ser Arg Leu Ser Gin Cys 290 295 300

Pro Glu Val His Pro 305 (2)序列編號NO: 535資料： (i)序列特性： (A)長度：309胺基酸 O:\92\92747.DOC 296- 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 535

Ala Asn Cys Ser lie Met lie Asp Glu lie He His His Leu Lys Arg 15 10 15

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30

Ser He Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45

Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr He Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Val Leu Leu Pro Ala Val Asp Phe Ser Leu Gly Glu Trp Lys 145 150 155 160

Thr Gin Met Glu Glu Thr Lys Ala Gin Asp lie Leu Gly Ala Val Thr 165 170 175

Leu Leu Leu Glu Gly Val Met Ala Ala Arg Gly Gin Leu Gly Pro Thr 180 185 190

Cys Leu Ser Ser Leu Leu Gly Gin Leu Ser Gly Gin Val Arg Leu Leu 195 200 205

Leu Gly Ala Leu Gin Ser Leu Leu Gly Thr Gin Leu Pro Pro Gin Gly 210 215 220

Arg Thr Thr Ala His Lys Asp Pro Asn Ala lie Phe Leu Ser Phe Gin 225 230 235 240

His Leu Leu Arg Gly Lys Val Arg Phe Leu Met Leu Val Gly Gly Ser 245 250 255

Thr Leu Cys Val Arg Glu Phe Gly Gly Asn Gly Gly Asn Met Ala Ser 260 265 270

Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser Lys Leu Leu Arg 275 280 285

Asp Ser His Val Leu His Ser Arg Leu Ser Gin Cys Pro Glu Val His 290 295 300

Pro Leu Pro Thr Pro 305 (2)序列編號NO: 536資料： (i)序列特性： (A)長度：309胺基酸 O:\92\92747.DOC 297 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (Π)分子類型：無 (xi)序列描述：序列編號NO: 536

Ala Asn Cys Ser lie Met lie Asp Glu He lie His His Leu Lys Arg 15 10 15

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30

Ser He Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45

Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie He He Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Val Asp Phe Ser Leu Gly Glu Trp Lys Thr Gin Met Glu 145 150 155 160

Glu Thr Lys Ala Gin Asp lie Leu Gly Ala Val Thr Leu Leu Leu Glu 165 170 175

Gly Val Met Ala Ala Arg Gly Gin Leu Gly Pro Thr Cys Leu Ser Ser 180 185 190

Leu Leu Gly Gin Leu Ser Gly Gin Val Arg Leu Leu Leu Gly Ala Leu 195 200 205

Gin Ser Leu Leu Gly Thr Gin Leu Pro Pro Gin Gly Arg Thr Thr Ala 210 215 220

His Lys Asp Pro Asn Ala He Phe Leu Ser Phe Gin His Leu Leu Arg 225 230 235 240

Gly Lys Val Arg Phe Leu Met Leu Val Gly Gly Ser Thr Leu Cys Val 245 250 255

Arg Glu Phe Gly Gly Asn Gly Gly Asn Met Ala Ser Pro Ala Pro Pro 260 265 270

Ala Cys Asp Leu Arg Val Leu Ser Lys Leu Leu Arg Asp Ser His Val 275 280 285

Leu His Ser Arg Leu Ser Gin Cys Pro Glu Val His Pro Leu Pro Thr 290 295 300

Pro Val Leu Leu Pro 305 (2)序列編號NO·. 537資料： (i)序列特性： (A)長度：309胺基酸 O:\92\92747.DOC 298 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 537

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30

Ser He Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45

Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie He Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Asp Phe Ser Leu Gly Glu Trp Lys Thr Gin Met Glu Glu Thr 145 150 155 160

Lys Ala Gin Asp lie Leu Gly Ala Val Thr Leu Leu Leu Glu Gly Val 165 170 175

Met Ala Ala Arg Gly Gin Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu 180 185 190

Gly Gin Leu Ser Gly Gin Val Arg Leu Leu Leu Gly Ala Leu Gin Ser 195 200 205

Leu Leu Gly Thr Gin Leu Pro Pro Gin Gly Arg Thr Thr Ala His Lys 210 215 220

Asp Pro Asn Ala lie Phe Leu Ser Phe Gin His Leu Leu Arg Gly Lys 225 230 235 240

Val Arg Phe Leu Met Leu Val Gly Gly Ser Thr Leu Cys Val Arg Glu 245 250 255

Phe Gly Gly Asn Gly Gly Asn Met Ala Ser Pro Ala Pro Pro Ala Cys 260 265 270

Asp Leu Arg Val Leu Ser Lys Leu Leu Arg Asp Ser His Val Leu His 275 280 285

Ser Arg Leu Ser Gin Cys Pro Glu Val His Pro Leu Pro Thr Pro Val 290 295 300

Leu Leu Pro Ala Val 305 (2)序列編號NO·· 538資料： (i)序列特性： (A)長度：309胺基酸 O:\92\92747.DOC -299 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO·. 538

Ala Asn Cys Ser He Met He Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30

Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45

Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Gly Gin Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gin Leu Ser 180 185 190

Gly Gin Val Arg Leu Leu Leu Gly Ala Leu Gin Ser Leu Leu Gly Thr 195 200 205

Met Leu Val Gly Gly Ser Thr Leu Cys Val Arg Glu Phe Gly Gly Asn 245 250 255

Gly Gly Asn Met Ala Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val 260 265 270

Leu Ser Lys Leu Leu Arg Asp Ser His Val Leu His Ser Arg Leu Ser 275 280 285

Gin Cys Pro Glu Val His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala 290 295 300

Val Asp Phe Ser Leu 305 (2)序列編號NO: 539資料： (i)序列特性： (A)長度：309胺基酸 O:\92\92747.DOC -300- 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (Π)分子類型：無 (xi)序列描述：序列編號NO: 539

Ala Asn Cys Ser lie Met lie Asp Glu lie He His His Leu Lys Arg 1 5 10 15

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30

Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45

Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly He Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gin Leu Ser Gly 145 150 155 160

Gin Val Arg Leu Leu Leu Gly Ala Leu Gin Ser Leu Leu Gly Thr Gin 165 170 175

Leu Pro Pro Gin Gly Arg Thr Thr Ala His Lys Asp Pro Asn Ala He 180 185 190

Phe Leu Ser Phe Gin His Leu Leu Arg Gly Lys Val Arg Phe Leu Met 195 200 205

Leu Val Gly Gly Ser Thr Leu Cys Val Arg Glu Phe Gly Gly Asn Gly 210 215 220

Gly Asn Met Ala Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu 225 230 235 240

Ser Lys Leu Leu Arg Asp Ser His Val Leu His Ser Arg Leu Ser Gin 245 250 255

Cys Pro Glu Val His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala Val 260 265 270

Asp Phe Ser Leu Gly Glu Trp Lys Thr Gin Met Glu Glu Thr Lys Ala 275 280 285

Gin Asp lie Leu Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala 290 295 300

Ala Arg Gly Gin Leu 305 (2)序列編號NO: 540資料： (i)序列特性： (A)長度：309胺基酸 O:\92\92747.DOC 301- (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 540

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30

Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45

Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly He Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie He lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr He Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Gly Thr Gin Leu Pro Pro Gin Gly Arg Thr Thr Ala His Lys 145 150 155 160

Asp Pro Asn Ala lie Phe Leu Ser Phe Gin His Leu Leu Arg Gly Lys 165 170 175

Val Arg Phe Leu Met Leu Val Gly Gly Ser Thr Leu Cys Val Arg Glu 180 185 190

Phe Gly Gly Asn Gly Gly Asn Met Ala Ser Pro Ala Pro Pro Ala Cys 195 200 205

Asp Leu Arg Val Leu Ser Lys Leu Leu Arg Asp Ser His Val Leu His 210 215 220

Ser Arg Leu Ser Gin Cys Pro Glu Val His Pro Leu Pro Thr Pro Val 225 230 235 240

Leu Leu Pro Ala Val Asp Phe Ser Leu Gly Glu Trp Lys Thr Gin Met 245 250 255

Glu Glu Thr Lys Ala Gin Asp lie Leu Gly Ala Val Thr Leu Leu Leu 260 265 270

Glu Gly Val Met Ala Ala Arg Gly Gin Leu Gly Pro Thr Cys Leu Ser 275 280 285

Ser Leu Leu Gly Gin Leu Ser Gly Gin Val Arg Leu Leu Leu Gly Ala 290 295 300

Leu Gin Ser Leu Leu 305 (2)序列編號NO: 541資料： (i)序列特性： (A)長度：309胺基酸 302-

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Ala Asn Cys Ser He Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30

Ser He Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45

Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly He Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie He Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Gly Arg Thr Thr Ala His Lys Asp Pro Asn Ala lie Phe Leu 145 150 155 160

Ser Phe Gin His Leu Leu Arg Gly Lys Val Arg Phe Leu Met Leu Val 165 170 175

Gly Gly Ser Thr Leu Cys Val Arg Glu Phe Gly Gly Asn Gly Gly Asn 180 185 190

Met Ala Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser Lys 195 200 205

Leu Leu Arg Asp Ser His Val Leu His Ser Arg Leu Ser Gin Cys Pro 210 215 220

Glu Val His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala Val Asp Phe 225 230 235 240

Ser Leu Gly Glu Trp Lys Thr Gin Met Glu Glu Thr Lys Ala Gin Asp 245 250 255

He Leu Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala Ala Arg 260 265 270

Gly Gin Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gin Leu Ser 275 280 285

Gly Gin Val Arg Leu Leu Leu Gly Ala Leu Gin Ser Leu Leu Gly Thr 290 295 300

Gin Leu Pro Pro Gin 305 (2)序列編號NO: 542資料： (i)序列特性： (A)長度：309胺基酸 O:\92\92747.DOC -303- (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 542

Ala Asn Cys Ser lie Met lie Asp Glu lie He His His Leu Lys Arg 15 10 15

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30

Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45

Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie He Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala His Lys Asp Pro Asn Ala lie Phe Leu Ser Phe Gin His 145 150 155 160

Leu Leu Arg Gly Lys Val Arg Phe Leu Met Leu Val Gly Gly Ser Thr 165 170 175

Leu Cys Val Arg Glu Phe Gly Gly Asn Gly Gly Asn Met Ala Ser Pro 180 185 190

Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser Lys Leu Leu Arg Asp 195 200 205

Ser His Val Leu His Ser Arg Leu Ser Gin Cys Pro Glu Val His Pro 210 215 220

Leu Pro Thr Pro Val Leu Leu Pro Ala Val Asp Phe Ser Leu Gly Glu 225 230 235 240

Trp Lys Thr Gin Met Glu Glu Thr Lys Ala Gin Asp He Leu Gly Ala 245 250 255

Val Thr Leu Leu Leu Glu Gly Val Met Ala Ala Arg Gly Gin Leu Gly 260 265 270

Pro Thr Cys Leu Ser Ser Leu Leu Gly Gin Leu Ser Gly Gin Val Arg 275 280 285

Leu Leu Leu Gly Ala Leu Gin Ser Leu Leu Gly Thr Gin Leu Pro Pro 290 295 300

Gin Gly Arg Thr Thr 305 (2)序列編號NO: 543資料： (i)序列特性： (A)長度：309胺基酸 -304-

O:\92\92747.DOC (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 543

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30

Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45

Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Asp Pro Asn Ala lie Phe Leu Ser Phe Gin His Leu Leu Arg 145 150 155 160

Gly Lys Val Arg Phe Leu Met Leu Val Gly Gly Ser Thr Leu Cys Val 165 170 175

Arg Glu Phe Gly Gly Asn Gly Gly Asn Met Ala Ser Pro Ala Pro Pro 180 185 190

Ala Cys Asp Leu Arg Val Leu Ser Lys Leu Leu Arg Asp Ser His Val 195 200 205

Leu His Ser Arg Leu Ser Gin Cys Pro Glu Val His Pro Leu Pro Thr 210 215 220

Pro Val Leu Leu Pro Ala Val Asp Phe Ser Leu Gly Glu Trp Lys Thr 225 230 235 240

Gin Met Glu Glu Thr Lys Ala Gin Asp lie Leu Gly Ala Val Thr Leu 245 250 255

Leu Leu Glu Gly Val Met Ala Ala Arg Gly Gin Leu Gly Pro Thr Cys 260 265 270

Leu Ser Ser Leu Leu Gly Gin Leu Ser Gly Gin Val Arg Leu Leu Leu 275 280 285

Gly Ala Leu Gin Ser Leu Leu Gly Thr Gin Leu Pro Pro Gin Gly Arg 290 295 300

Thr Thr Ala His Lys 305 (2)序列編號NO: 544資料： (i)序列特性： (A)長度：309胺基酸 305

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Ala Asn Cys Ser He Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30

Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45

Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala He 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala lie Phe Leu Ser Phe Gin His Leu Leu Arg Gly Lys Val 145 150 155 160

Arg Phe Leu Met Leu Val Gly Gly Ser Thr Leu Cys Val Arg Glu Phe 165 170 175

Gly Gly Asn Gly Gly Asn Met Ala Ser Pro Ala Pro Pro Ala Cys Asp 180 185 190

Leu Arg Val Leu Ser Lys Leu Leu Arg Asp Ser His Val Leu His Ser 195 200 205

Arg Leu Ser Gin Cys Pro Glu Val His Pro Leu Pro Thr Pro Val Leu 210 215 220

Leu Pro Ala Val Asp Phe Ser Leu Gly Glu Trp Lys Thr Gin Met Glu 225 230 235 240

Glu Thr Lys Ala Gin Asp He Leu Gly Ala Val Thr Leu Leu Leu Glu 245 250 255

Gly Val Met Ala Ala Arg Gly Gin Leu Gly Pro Thr Cys Leu Ser Ser 260 265 270

Leu Leu Gly Gin Leu Ser Gly Gin Val Arg Leu Leu Leu Gly Ala Leu 275 280 285

Gin Ser Leu Leu Gly Thr Gin Leu Pro Pro Gin Gly Arg Thr Thr Ala 290 295 300

His Lys Asp Pro Asn 305 (2)序列編號NO: 545資料： (i)序列特性： (A)長度：302胺基酸 O:\92\92747.DOC 306- 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 545

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 1 5 10 15

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30

Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45

Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Asp Pro Asn Ala lie Phe Leu Ser Phe Gin His Leu Leu Arg 145 150 155 160

Gly Lys Val Arg Phe Leu Met Leu Val Gly Gly Ser Thr Leu Cys Val 165 170 175

Arg Glu Phe Gly Gly Asn Met Ala Ser Pro Ala Pro Pro Ala Cys Asp 180 185 190

Leu Arg Val Leu Ser Lys Leu Leu Arg Asp Ser His Val Leu His Ser 195 200 205

Arg Leu Ser Gin Cys Pro Glu Val His Pro Leu Pro Thr Pro Val Leu 210 215 220

Leu Pro Ala Val Asp Phe Ser Leu Gly Glu Trp Lys Thr Gin Met Glu 225 230 235 240

Glu Thr Lys Ala Gin Asp lie Leu Gly Ala Val Thr Leu Leu Leu Glu 245 250 255

Gly Val Met Ala Ala Arg Gly Gin Leu Gly Pro Thr Cys Leu Ser Ser 260 265 270

Leu Leu Gly Gin Leu Ser Gly Gin Val Arg Leu Leu Leu Gly Ala Leu 275 280 285

Gin Ser Leu Leu Gly Thr Gin Gly Arg Thr Thr Ala His Lys 290 295 300 (2)序列編號NO: 546資料： (i)序列特性： (A) 長度：153胺基酸 (B) 形式：胺基酸 O:\92\92747.DOC -307 200413407 (c)股數：單 (D)拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 546

Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser Lys Leu Leu 1 5 10 15

Arg Asp Ser His Val Leu His Ser Arg Leu Ser Gin Cys Pro Glu Val 20 25 30

His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala Val Asp Phe Ser Leu 35 40 45

Gly Glu Trp Lys Thr Gin Met Glu Glu Thr Lys Ala Gin Asp lie Leu 50 55 60

Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala Ala Arg Gly Gin 65 70 75 80

Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gin Leu Ser Gly Gin 85 90 95

Val Arg Leu Leu Leu Gly Ala Leu Gin Ser Leu Leu Gly Thr Gin Leu 100 105 110

Pro Pro Gin Gly Arg Thr Thr Ala His Lys Asp Pro Asn Ala He Phe 115 120 125

Leu Ser Phe Gin His Leu Leu Arg Gly Lys Val Arg Phe Leu Met Leu 130 135 140

Val Gly Gly Ser Thr Leu Cys Val Arg 145 150 (2)序列編號NO: 547資料： (i) 序列特性： (A) 長度：149胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 547

Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser Lys Leu Leu 15 10 15

Arg Asp Ser His Val Leu His Ser Arg Leu Ser Gin Cys Pro Glu Val 20 25 30

His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala Val Asp Phe Ser Leu 35 40 45

Gly Glu Trp Lys Thr Gin Met Glu Glu Thr Lys Ala Gin Asp lie Leu 50 55 60

Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala Ala Arg Gly Gin 65 70 75 80

Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gin Leu Ser Gly Gin 85 90 95 -308

O:\92\92747.DOC 200413407

Val Arg Leu Leu Leu Gly Ala Leu Gin Ser Leu Leu Gly Thr Gin Gly 100 105 110

Arg Thr Thr Ala His Lys Asp Pro Asn Ala lie Phe Leu Ser Phe Gin 115 120 125

His Leu Leu Arg Gly Lys Val Arg Phe Leu Met Leu Val Gly Gly Ser 130 135 140

Thr Leu Cys Val Arg 145 (2)序列編號NO: 548資料： (i) 序列特性： (A) 長度：153胺基酸 (B) 形式：胺基酸

(C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 548

Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser Lys Leu Leu 15 10 15

Arg Asp Ser His Val Leu His Ser Arg Leu Ser Gin Cys Pro Glu Val 20 25 30

His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala Val Asp Phe Ser Leu 35 40 45

Gly Glu Trp Lys Thr Gin Met Glu Glu Thr Lys Ala Gin Asp lie Leu 50 55 60

Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala Ala Arg Gly Gin 65 70 75 80

Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gin Leu Ser Gly Gin

85 90 95

Val Arg Leu Leu Leu Gly Ala Leu Gin Ser Leu Leu Gly Thr Gin Leu 100 105 110

Pro Pro Gin Gly Arg Thr Thr Ala His Lys Asp Pro Asn Ala lie Phe 115 120 125

Leu Ser Phe Gin His Leu Leu Arg Gly Lys Val Arg Phe Leu Met Leu 130 135 140

Val Gly Gly Ser Thr Leu Cys Val Arg 145 150 (2)序列編號NO: 549資料： (i)序列特性： (A) 長度：135胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 O:\92\92747.DOC 309- 200413407 (ii)分子類型：無 (xi)序列描述：序列編號NO: 549

Ala Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe 15 10 15

Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro 20 25 30

Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Ala Leu 35 40 45

Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val 50 55 60

Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie 65 70 75 80

His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg 85 90 95

Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin 100 105 110

Leu Val Ala Leu Lys Pro Trp He Thr Arg Gin Asn Phe Ser Arg Cys 115 120 125

Leu Glu Leu Gin Cys Gin Pro 130 135 (2)序列編號NO: 550資料： (i) 序列特性： (A) 長度：140胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形

(ii) 分子類型：無 (xi)序列描述：序列編號NO: 550

Ala Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe 15 10 15

Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro 20 25 30

Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu 35 40 45

Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val 50 55 60

Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie 65 70 75 80

His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg 85 90 95

Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin 100 105 110

Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys 115 120 125

Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu 130 135 140 O:\92\92747.DOC -310 200413407 (2)序列編號NO: 551資料： (i) 序列特性： (A) 長度：122胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 551

Ala Thr Gin Asp Cys Ser Phe Gin His Ser Pro He Ser Ser Asp Phe 15 10 15

Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro 20 25 30

Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu 35 40 45

Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val 50 55 60

Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie 65 70 75 80

His Phe Val Thr Lys Cys Ala Phe Gin Glu Thr Ser Glu Gin Leu Val 85 90 95

Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu 100 105 110

Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu 115 120 (2)序列編號NO: 552資料：

(i) 序列特性： (A) 長度：135胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 552

Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe 15 10 15

Ala Val Lys He Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro 20 25 30

Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu 35 40 45 O:\92\92747.DOC -311- 200413407

Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val 50 55 60

Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie 65 70 75 80

His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg 85 90 95

Phe Val Gin Thr Asn He Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin 100 105 110

Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys 115 120 125

Leu Glu Leu Gin Cys Gin Pro 130 135 (2)序列編號NO: 553資料： (i) 序列特性：

(A) 長度：140胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 553

Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe 15 10 15

Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro 20 25 30

Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu 35 40 45

Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val 50 55 60

Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu He 65 70 75 80

His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg 85 90 95

Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin 100 105 110

Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys 115 120 125

Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu 130 135 140 (2)序列編號NO: 554資料： (i)序列特性： (A) 長度：135胺基酸 (B) 形式：胺基酸 (C) 股數：單 O:\92\92747.DOC -312 200413407 (D)拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 554

Ala Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe 15 10 15

Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro 20 25 30

Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu 35 40 45

Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val 50 55 60

Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie 65 70 75 80

His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg

85 90 95

Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin 100 105 110

Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys 115 120 125

Leu Glu Leu Gin Cys Gin Pro 130 135 (2)序列編號NO: 555資料： (0序列特性： (A) 長度：140胺基酸 (B) 形式：胺基酸 (C) 股數：單

(D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 555

Ala Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe 15 10 15

Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro 20 25 30

Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu 35 40 45

Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val 50 55 60

Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie 65 70 75 80

His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg 85 90 95

Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin 100 105 110

Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys 115 120 125 O:\92\92747.DOC -313- 200413407

Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu 130 135 140 (2)序列編號NO: 556資料： (i) 序列特性： (A) 長度：155胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無

(xi)序列描述：序列編號NO: 556

Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 15 10 15

Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly 20 25 30

Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala 35 40 45

Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser 50 55 60

Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp 65 70 75 80 lie Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro 85 90 95

Asp Ser Ser Thr Leu Ser Gly Gly Asn Gly Ser Gly Gly Asn Gly Ser 100 105 110

Gly Gly Asn Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro He Ser 115 120 125

Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin 130 135 140

Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin 145 150 155 (2)序列編號NO: 557資料： (i)序列特性： (A) 長度：150胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (Π)分子類型：無 (xi)序列描述：序列編號NO: 557 O:\92\92747.DOC -314- 200413407

Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 15 10 15

Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly 20 25 30

Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala 35 40 45

Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser 50 55 60

Asp Ser Ser Thr Leu Ser Gly Gly Asn Gly Ser Gly Gly Asn Gly Thr 100 105 110

Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala Val 115 120 125

Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr 130 135 140

Val Ala Ser Asn Leu Gin 145 150 (2)序列編號NO: 558資料： (i)序列特性： (A) 長度：145胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (Π)分子類型：無 (xi)序列描述：序列編號NO: 558

Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 1 5 10 15

Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly 20 25 30

Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala 35 40 45

Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser 50 55 60

Asp Ser Ser Thr Leu Ser Gly Gly Asn Gly Thr Gin Asp Cys Ser Phe 100 105 110

Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu 115 120 125

Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 130 135 140

Gin 145 O:\92\92747. -315- 200413407 (2)序列編號NO: 559資料： (i) 序列特性： (A) 長度：155胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 559

Ala Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie His 15 10 15

Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe 20 25 30

Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu 35 40 45

Val Ala Leu Lys Pro Trp He Thr Arg Gin Asn Phe Ser Arg Cys Leu 50 55 60

Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Ser Gly Gly Asn Gly 65 70 75 80

Ser Gly Gly Asn Gly Ser Gly Gly Asn Gly Thr Gin Asp Cys Ser Phe 85 90 95

Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu 100 105 110

Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 115 120 125

Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 130 135 140

Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly 145 150 155

(2)序列編號NO: 560資料： (i) 序列特性： (A) 長度：150胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 560

Ala Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie His 15 10 15

Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe O:\92\92747.DOC -316- 200413407 20 25 30

Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu 35 40 45

Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys Leu 50 55 60

Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Ser Gly Gly Asn Gly 65 70 75 80

Ser Gly Gly Asn Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie 85 90 95

Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu 100 105 110

Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu 115 120 125

Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg 130 135 140

Leu Lys Thr Val Ala Gly 145 150

(2)序列編號NO: 561資料： (i) 序列特性： (A) 長度：145胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 561

Ala Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie His 15 10 15

Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe 20 25 30

Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu 35 40 45

Val Ala Leu Lys Pro Trp He Thr Arg Gin Asn Phe Ser Arg Cys Leu 50 55 60

Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Ser Gly Gly Asn Gly 65 70 75 80

Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala 85 90 95

Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val 100 105 110

Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp 115 120 125

Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala 130 135 140

Gly 145 (2)序列編號NO: 562資料： O:\92\92747.DOC 317- 200413407 (i) 序列特性： (A) 長度：155胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 562

Ala Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser Arg Leu 15 10 15

Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp lie Thr 20 25 30

Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser 35 40 45

Ser Thr Leu Ser Gly Gly Asn Gly Ser Gly Gly Asn Gly Ser Gly Gly 50 55 60

Asn Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp 65 70 75 80

Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr 85 90 95

Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly 100 105 110

Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr 115 120 125

Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu 130 135 140 lie His Phe Val Thr Lys Cys Ala Phe Gin Pro 145 150 155

(2)序列編號NO: 563資料： (i) 序列特性： (A) 長度：150胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 563

Ala Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser Arg Leu 15 10 15

Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp lie Thr 20 25 30

Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser O:\92\92747.DOC •318- 200413407 35 40 45

Ser Thr Leu Ser Gly Gly Asn Gly Ser Gly Gly Asn Gly Thr Gin Asp 50 55 60

Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie 65 70 75 80

Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala 85 90 95

Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val 100 105 110

Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys 115 120 125

Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr 130 135 140

Lys Cys Ala Phe Gin Pro 145 150 (2)序列編號NO: 564資料：

(i) 序列特性： (A) 長度：145胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 564

Ala Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser Arg Leu 15 10 15

Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp lie Thr 20 25 30

Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser 35 40 45

Ser Thr Leu Ser Gly Gly Asn Gly Thr Gin Asp Cys Ser Phe Gin His 50 55 60

Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser Asp 65 70 75 80

Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Asp 85 90 95

Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin Arg Trp 100 105 110

Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly Leu Leu 115 120 125

Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala Phe Gin 130 135 140

Pro 145 (2)序列編號NO: 565資料： (i)序列特性： O:\92\92747.DOC -319- 200413407 (A) 長度：155胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 565

Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 15 10 15

Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly 20 25 30

Leu Leu Glu Arg Val Asn Thr Glu He His Phe Val Thr Lys Cys Ala 35 40 45

Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn He Ser 50 55 60

Asp Ser Ser Thr Leu Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser 100 105 110

Gly Gly Ser Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser 115 120 125

Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin 130 135 140

Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin 145 150 155 (2)序列編號NO: 566資料：

(i) 序列特性： (A) 長度：150胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 566

Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 15 10 15

Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly 20 25 30

Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala 35 40 45

Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser 50 55 60 O:\92\92747.DOC -320 200413407

Asp Ser Ser Thr Leu Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly Thr 100 105 110

Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala Val 115 120 125

Lys He Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr 130 135 140

Val Ala Ser Asn Leu Gin 145 150 (2)序列編號NO: 567資料： (i)序列特性：

(A) 長度：145胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (Π)分子類型：無 (xi)序列描述：序列編號NO: 567

Met Ala Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp 15 10 15

Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr 20 25 30

Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly 35 40 45

Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr

50 55 60

Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu 65 70 75 80 lie His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu 85 90 95

Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu 100 105 110

Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg 115 120 125

Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly 130 135 140

Ser 145 (2)序列編號NO: 568資料： (i)序列特性： (A) 長度：143胺基酸 (B) 形式：胺基酸 O:\92\92747.DOC -321- 200413407 (c)股數：單 (D)拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 568

Gly Ser Gly Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser 15 10 15

Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin 20 25 30

Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys 35 40 45

Gly Gly Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu 50 55 60

Lys Thr Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn

65 70 75 80

Thr Glu He His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser 85 90 95

Cys Leu Arg Phe Val Gin Thr Asn He Ser Arg Leu Leu Gin Glu Thr 100 105 110

Ser Glu Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe 115 120 125

Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu 130 135 140 (2)序列編號NO: 569資料： (i) 序列特性： (A) 長度：149胺基酸 (B) 形式：胺基酸

(C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 569

Met Ala Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp 15 10 15

Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr 20 25 30

Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly 35 40 45

Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr 50 55 60

Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu 65 70 75 80

He His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu 85 90 95

Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu 100 105 110 O:\92\92747.DOC -322- 200413407

Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg 115 120 125

Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly 130 135 140

Ser Gly Gly Gly Ser 145 (2)序列編號NO: 570資料： (i) 序列特性： (A) 長度：144胺基酸 (B) 形式：胺基酸 (C) 股數：單

(D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO·. 570

Gly Ser Gly Gly Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie 1 5 10 15

Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu 20 25 30

Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu 35 40 45

Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg 50 55 60

Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val 65 70 75 80

Asn Thr Glu He His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro 85 90 95

Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu 100 105 110

Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn 115 120 125

Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu 130 135 140 (2)序列編號NO: 571資料： (i) 序列特性： (A) 長度：153胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 O:\92\92747.DOC -323- 200413407 (xi)序列描述：序列編號NO: 571

Met Ala Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp 15 10 15

Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr 20 25 30

Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly 35 40 45

Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr 50 55 60

Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu 100 105 110

Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg 115 120 125

Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly 130 135 140

Ser Gly Gly Gly Ser Gly Gly Gly Ser 145 150 (2)序列編號NO: 572資料： (i) 序列特性： (A) 長度：150胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形

(ii) 分子類型：無 (xi)序列描述：序列編號NO: 572

Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp Cys Ser 15 10 15

Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu 20 25 30

Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn 35 40 45

Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala 50 55 60

Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin 65 70 75 80

Gly Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys 85 90 95

Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie 100 105 110

Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro 115 120 125

Trp lie Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin 130 135 140 O:\92\92747.DOC -324- 200413407

Pro Asp Ser Ser Thr Leu 145 150 (2)序列編號NO: 573資料： (i)序列特性： (A) 長度：146胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (Π)分子類型：無

(xi)序列描述：序列編號NO·. 573

Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 15 10 15

Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly 20 25 30

Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala 35 40 45

Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser 50 55 60

Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Thr Gin Asp Cys Ser 100 105 110

Phe Gin His Ser Pro He Ser Ser Asp Phe Ala Val Lys He Arg Glu 115 120 125

Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn 130 135 140

Leu Gin 145 (2)序列編號NO: 574資料： (i) 序列特性： (A) 長度：147胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 574 O:\92\92747.DOC -325- 200413407

Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 15 10 15

Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly 20 25 30

Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala 35 40 45

Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser 50 55 60

Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Thr Gin Asp Cys 100 105 110

Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg 115 120 125

Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser 130 135 140

Asn Leu Gin 145 (2)序列編號NO: 575資料： (i)序列特性： (A) 長度：150胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (Π)分子類型：無 (xi)序列描述：序列編號NO: 575

Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 15 10 15

Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly 20 25 30

Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala 35 40 45

Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn He Ser 50 55 60

Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Thr 100 105 110

Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala Val 115 120 125

Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr 130 135 140

Val Ala Ser Asn Leu Gin 145 150 O:\92\92747.DOC -326 200413407 (2)序列編號NO: 576資料： (i)序列特性： (A) 長度：153胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (Π)分子類型：無 (xi)序列描述：序列編號NO: 576

Ala Asp Glu Glu Leu Cys Gly Gly Leu T-rp Arg Leu Val Leu Ala Gin 15 10 15

Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly 20 25 30

Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala 35 40 45

Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser 50 55 60

Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 100 105 110

Ser Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp 115 120 125

Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr 130 135 140

Pro Val Thr Val Ala Ser Asn Leu Gin 145 150

(2)序列編號NO: 577資料： (i) 序列特性： (A) 長度：155胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 577

Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 15 10 15

Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly O:\92\92747.DOC -327 200413407 20 25 30

Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala 35 40 45

Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser 50 55 60

Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 100 105 110

Ser Gly Gly Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser 115 120 125

Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin 130 135 140

Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin 145 150 155

(2)序列編號NO: 578資料： (i) 序列特性： (A) 長度：161胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 578

Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 15 10 15

Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly 20 25 30

Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala 35 40 45

Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser 50 55 60

Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 100 105 110

Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp Cys Ser Phe 115 120 125

Gin His Ser Pro He Ser Ser Asp Phe Ala Val Lys He Arg Glu Leu 130 135 140

Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 145 150 155 160

Gin (2)序列編號NO·. 579資料： O:\92\92747.DOC -328- 200413407 (i) 序列特性： (A) 長度：281胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO.· 579

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val

20 25 30

Ser He Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45

Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly He Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser 145 150 155 160

Asp Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp 165 170 175

Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly 180 185 190

Ala Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys 195 200 205

Thr Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr 210 215 220

Glu lie His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys 225 230 235 240

Leu Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser 245 250 255

Glu Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser 260 265 270

Arg Cys Leu Glu Leu Gin Cys Gin Pro 275 280 (2)序列編號NO: 580資料： (i)序列特性： (A)長度·· 286胺基酸 O:\92\92747.DOC -329- 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (Π)分子類型：無 (xi)序列描述：序列編號NO: 580

Ala Asn Cys Ser He Met lie Asp Glu He lie His His Leu Lys Arg 15 10 15

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30

Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45

Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie He lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser 145 150 155 160

Asp Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp 165 170 175

Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly 180 185 190

Ala Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys 195 200 205

Thr Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr 210 215 220

Glu lie His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys 225 230 235 240

Leu Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser 245 250 255

Glu Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser 260 265 270

Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu 275 280 285 (2)序列編號NO: 581資料： (i)序列特性： (A) 長度：296胺基酸 (B) 形式：胺基酸 (C) 股數：單 O:\92\92747.DOC -330- (D)拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 581

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30

Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45

Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala He 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu 145 150 155 160

Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met 165 170 175

Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys 180 185 190

Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn 195 200 205

He Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys 210 215 220

Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys 225 230 235 240

Gin Pro Asp Ser Ser Thr Leu Ser Gly Gly Asn Gly Ser Gly Gly Asn 245 250 255

Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe 260 265 270

Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro 275 280 285

Val Thr Val Ala Ser Asn Leu Gin 290 295 (2)序列編號NO: 582資料： (i)序列特性： (A) 長度：296胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 -331-

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Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30

Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45

Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie He lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu 145 150 155 160

Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met 165 170 175

Gin Gly Leu Leu Glu Arg Val Asn Thr Glu He His Phe Val Thr Lys 180 185 190

Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn 195 200 205

He Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys 210 215 220

Pro Trp He Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys 225 230 235 240

Gin Pro Asp Ser Ser Thr Leu Ser Gly Gly Asn Gly Ser Gly Gly Asn 245 250 255

Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe 260 265 270

Ala Val Lys He Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro 275 280 285

Val Thr Val Ala Ser Asn Leu Gin 290 295 (2)序列編號NO: 583資料： (i) 序列特性： (A) 長度· 291胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 -332-

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Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg i 5 10 15

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30

Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45

Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly He Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro He He He Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu 145 150 155 160 lie His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu 165 170 175

Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu 180 185 190

Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg 195 200 205

Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Ser Gly Gly 210 215 220

Asn Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp 225 230 235 240

Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr 245 250 255

Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly 260 265 270

Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr 275 280 285

Val Ala Gly 290 (2)序列編號NO: 584資料： (i) 序列特性： (A) 長度：296胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 584 -333-

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Ala Asn Cys Ser lie Met lie Asp Glu He lie His His Leu Lys Arg 15 10 15

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30

Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45

Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu 180 185 190

Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg 195 200 205

Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Ser Gly Gly 210 215 220

Asn Gly Ser Gly Gly Asn Gly Thr Gin Asp Cys Ser Phe Gin His Ser 225. 230 235 240

Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr 245 250 255

Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu 260 265 270

Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met 275 280 285

Glu Arg Leu Lys Thr Val Ala Gly 290 295 (2)序列編號NO: 585資料： (i) 序列特性： (A) 長度：301胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 585

Ala Asn Cys Ser lie Met lie Asp Glu lie He His His Leu Lys Arg 15 10 15

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30 334-

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Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45

Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly He Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie He Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He 115 120 125

Ser Thr He Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu 145 150 155 160

Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met 165 170 175

Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys 180 185 190

Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn 195 200 205 lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys 210 215 220

Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys 225 230 235 240

Gin Pro Asp Ser Ser Thr Leu Ser Gly Gly Asn Gly Ser Gly Gly Asn 245 250 255

Gly Ser Gly Gly Asn Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro 260 265 270

He Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu 275 280 285

Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin 290 295 300 (2)序列編號NO: 586資料： (i) 序列特性： (A) 長度：291胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 586

Ala Asn Cys Ser He Met He Asp Glu lie lie His His Leu Lys Arg 1 5 10 15

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30

Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45

Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60 -335

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Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn He Ser 145 150 155 160

Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp 165 170 175 lie Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro 180 185 190

Asp Ser Ser Thr Leu Ser Gly Gly Asn Gly Thr Gin Asp Cys Ser Phe 195 200 205

Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu 210 215 220

Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 225 230 235 240

Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 245 250 255

Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly 260 265 270

Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala 275 280 285

Phe Gin Pro 290 (2)序列編號NO: 587資料： (i) 序列特性： (A) 長度：296胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 587

Ala Asn Cys Ser He Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30

Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45

Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie He Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95 -336-

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Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser 145 150 155 160

Asp Ser Ser Thr Leu Ser Gly Gly Asn Gly Ser Gly Gly Asn Gly Thr 195 200 205

Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala Val 210 215 220

Lys He Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr 225 230 235 240

Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg 245 250 255

Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly 260 265 270

Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie His Phe 275 280 285

Val Thr Lys Cys Ala Phe Gin Pro 290 295 (2)序列編號NO: 588資料： (i)序列特性： (A) 長度：301胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (Π)分子類型：無 (xi)序列描述：序列編號NO: 588

Ala Asn Cys Ser He Met lie Asp Glu lie He His His Leu Lys Arg 15 10 15

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30

Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45

Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125 -337-

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Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn He Ser 145 150 155 160

Asp Ser Ser Thr Leu Ser Gly Gly Asn Gly Ser Gly Gly Asn Gly Ser 195 200 205

Gly Gly Asn Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser 210 215 220

Ser Asp Phe Ala Val Lys He Arg Glu Leu Ser Asp Tyr Leu Leu Gin 225 230 235 240

Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys 245 250 255

Gly Gly Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu 260 265 270

Lys Thr Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn 275 280 285

Thr Glu lie His Phe Val Thr Lys Cys Ala Phe Gin Pro 290 295 300 (2)序列編號NO: 589資料： (i) 序列特性： (A) 長度：281胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 589

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly He Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Thr Gin Asp Cys Ser Phe Gin His Ser Pro He Ser Ser 145 150 155 160 -338-

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Asp Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp 165 170 175

Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly 180 185 190

Gly Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys 195 200 205

Thr Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr 210 215 220

Glu He His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys 225 230 235 240

Leu Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser 245 250 255

Glu Gin Leu Val Ala Leu Lys Pro Trp He Thr Arg Gin Asn Phe Ser 260 265 270

Arg Cys Leu Glu Leu Gin Cys Gin Pro 275 280 (2)序列編號NO: 590資料： (i) 序列特性： (A) 長度：286胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 590

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp He Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Thr Gin Asp Cys Ser Phe Gin His Ser Pro He Ser Ser 145 150 155 160

Asp Phe Ala Val Lys He Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp 165 170 175

Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly 180 185 190

Gly Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys 195 200 205 -339-

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Thr Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr 210 215 220

Glu lie His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys 225 230 235 240

Leu Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser 245 250 255

Glu Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser 260 265 270

Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu 275 280 285 (2)序列編號NO: 591資料： (i) 序列特性： (A) 長度：296胺基酸 (B) 形式：胺基酸

(C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 591

Ala Asn Cys Ser lie Met lie Asp Glu He lie His His Leu Lys Arg 1 5 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu 145 150 155 160

Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met 165 170 175

Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys 180 185 190

Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys 225 230 235 240

Gin Pro Asp Ser Ser Thr Leu Ser Gly Gly Asn Gly Ser Gly Gly Asn 245 250 255 O:\92\92747.DOC -340-

Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe 260 265 270

Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro 275 280 285

Val Thr Val Ala Ser Asn Leu Gin 290 295 (2)序列編號NO: 592資料： (i) 序列特性： (A) 長度：301胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構·線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 592

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp He Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie He lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu 145 150 155 160

Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met 165 170 175

Gin Gly Leu Leu Glu Arg Val Asn Thr Glu He His Phe Val Thr Lys 180 185 190

Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys 225 230 235 240

Gin Pro Asp Ser Ser Thr Leu Ser Gly Gly Asn Gly Ser Gly Gly Asn 245 250 255

Gly Ser Gly Gly Asn Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro 260 265 270 lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu 275 280 285 -341-

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Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin 290 295 300 (2)序列編號NO: 593資料： (i) 序列特性： (A) 長度：291胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 593

Ala Asn Cys Ser He Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie He Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu 145 150 155 160

He His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu 165 170 175

Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu 180 185 190

Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg 195 200 205

Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Ser Gly Gly 210 215 220

Asn Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp 225 230 235 240

Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr 245 250 255

Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly 260 265 270

Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr 275 280 285

Val Ala Gly 290 -342-

O:\92\92747.DOC 200413407 (2)序列編號NO: 594資料： (i) 序列特性： (A) 長度：296胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 594

Ala Asn Cys Ser lie Met lie Asp Glu lie He His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Arg Phe Val Gin Thr Asn He Ser Arg Leu Leu Gin Glu Thr Ser Glu 180 185 190

Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg 195 200 205

Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Ser Gly Gly 210 215 220

Asn Gly Ser Gly Gly Asn Gly Thr Gin Asp Cys Ser Phe Gin His Ser 225 230 235 240

Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr 245 250 255

Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu 260 265 270

Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met 275 280 285

Glu Arg Leu Lys Thr Val Ala Gly 290 295 (2)序列編號NO: 595資料： -343·

O:\92\92747.DOC 200413407 (i) 序列特性： (A) 長度：301胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 595

Ala Asn Cys Ser lie Met lie Asp Glu lie He His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie He lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu 180 185 190

Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg 195 200 205

Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Ser Gly Gly 210 215 220

Asn Gly Ser Gly Gly Asn Gly Ser Gly Gly Asn Gly Thr Gin Asp Cys 225 230 235 240

Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg 245 250 255

Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser 260 265 270

Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu 275 280 285

Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly 290 295 300 (2)序列編號NO: 596資料： (i)序列特性： O:\92\92747.DOC -344- (A) 長度：291胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 596

Ala Asn Cys Ser lie Met lie Asp Glu He lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly He Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser 145 150 155 160

Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp 165 170 175

He Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro 180 185 190

Asp Ser Ser Thr Leu Ser Gly Gly Asn Gly Thr Gin Asp Cys Ser Phe 195 200 205

Gin His Ser Pro lie’Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu 210 215 220

Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 225 230 235 240

Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 245 250 255

Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly 260 265 270

Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala 275 280 285

Phe Gin Pro 290 (2)序列編號NO: 597資料： (i)序列特性： (A)長度·· 296胺基酸 O:\92\92747.DOC -345- 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 597

Ala Asn Cys Ser lie Met He Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie

50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro He lie He Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser 145 150 155 160

Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp 165 170 175

He Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro 180 185 190

Asp Ser Ser Thr Leu Ser Gly Gly Asn Gly Ser Gly Gly Asn Gly Thr 195 200 205

Gin Asp Cys Ser Phe Gin His Ser Pro He Ser Ser Asp Phe Ala Val

210 215 220

Lys He Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr 225 230 235 240

Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg 245 250 255

Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly 260 265 270

Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie His Phe 275 280 285

Val Thr Lys Cys Ala Phe Gin Pro 290 295 (2)序列編號NO: 598資料： (i)序列特性： (A) 長度：301胺基酸 (B) 形式：胺基酸 O:\92\92747.DOC -346- (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 598

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie He lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr He Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser 145 150 155 160

Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp 165 170 175

He Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro 180 185 190

Asp Ser Ser Thr Leu Ser Gly Gly Asn Gly Ser Gly Gly Asn Gly Ser 195 200 205

Gly Gly Asn Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser 210 215 220

Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin 225 230 235 240

Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys 245 250 255

Gly Gly Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu 260 265 270

Lys Thr Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn 275 280 285

Thr Glu lie His Phe Val Thr Lys Cys Ala Phe Gin Pro 290 295 300 (2)序列編號NO: 599資料： (i)序列特性： (A) 長度：296胺基酸 (B) 形式：胺基酸 (C) 股數：單 -347

O:\92\92747.DOC 200413407 (D)拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 599

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp He Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie He Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He 115 120 125

Ser Thr He Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu 145 150 155 160

Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met 165 170 175

Gin Gly Leu Leu Glu Arg Val Asn Thr Glu He His Phe Val Thr Lys 180 185 190

Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys 225 230 235 240

Gin Pro Asp Ser Ser Thr Leu Ser Gly Gly Ser Gly Ser Gly Gly Ser

245 250 255

Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe 260 265 270

Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro 275 280 285

Val Thr Val Ala Ser Asn Leu Gin 290 295 (2)序列編號NO: 600資料： (i)序列特性： (A) 長度：301胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 O:\92\92747.DOC -348- 200413407 (ii)分子類型：無 (xi)序列描述：序列編號NO: 600

Ala Asn Cys Ser lie Met lie Asp Glu lie He His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala He 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu 145 150 155 160

Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met 165 170 175

Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys 180 185 190

Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn 195 200 205

He Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys 210 215 220

Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys 225 230 235 240

Gin Pro Asp Ser Ser Thr Leu Ser Gly Gly Ser Gly Ser Gly Gly Ser 245 250 255

Gly Ser Gly Gly Ser Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro 260 265 270 lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu 275 280 285

Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin 290 295 300 (2)序列編號NO: 601資料： (i) 序列特性： (A) 長度：281胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 O:\92\92747.DOC -349 200413407 (xi)序列描述：序列編號NO: 601

Ala Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe 15 10 15

Ala Val Lys He Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro 20 25 30

Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu 35 40 45

Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val 50 55 60

Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie 65 70 75 80

His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg 85 90 95

Phe Val Gin Thr Asn He Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin 100 105 110

Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys 115 120 125

Leu Glu Leu Gin Cys Gin Pro Tyr Val Glu Gly Gly Gly Gly Ser Pro 130 135 140

Gly Glu Pro Ser Gly Pro lie Ser Thr lie Asn Pro Ser Pro Pro Ser 145 150 155 160

Lys Glu Ser His Lys Ser Pro Asn Met Ala Asn Cys Ser lie Met lie 165 170 175

Asp Glu lie lie His His Leu Lys Arg Pro Pro Asn Pro Leu Leu Asp 180 185 190

Pro Asn Asn Leu Asn Ser Glu Asp Met Asp lie Leu Met Glu Arg Asn 195 200 205

Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg Ala Val Lys His Leu 210 215 220

Glu Asn Ala Ser Gly He Glu Ala lie Leu Arg Asn Leu Gin Pro Cys 225 230 235 240

Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro lie lie lie Lys 245 250 255

Ala Gly Asp Trp Gin Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val 260 265 270

Thr Leu Glu Gin Ala Gin Glu Gin Gin

275 280 (2)序列編號NO: 602資料： (i) 序列特性： (A) 長度：286胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 602

Ala Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe 15 10 15 O:\92\92747.DOC -350- 200413407

Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro 20 25 30

Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu 35 40 45

Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val 50 55 60

Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie 65 70 75 80

His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg 85 90 95

Phe Val Gin Thr Asn He Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin 100 105 110

Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys 115 120 125

Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Tyr Val Glu Gly 130 135 140

Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He Ser Thr lie Asn 145 150 155 160

Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Asn

165 170 175

Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg Pro Pro 180 185 190

Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met Asp lie 195 200 205

Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg 210 215 220

Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie Leu Arg 225 230 235 240

Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His 245 250 255

Pro lie He lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu Lys Leu 260 265 270

Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 275 280 285 (2)序列編號NO: 603資料：

(i)序列特性： (A) 長度：268胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (Π)分子類型：無 (xi)序列描述：序列編號NO: 603

Ala Asn Cys Ser lie Met He Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60 O:\92\92747.DOC -351- 200413407

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Pro His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser 145 150 155 160

Asp Phe Ala Val Lys He Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp 165 170 175

Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly 180 185 190

Gly Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys 195 200 205

Thr Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr 210 215 220

Glu lie His Phe Val Thr Lys Cys Ala Phe Gin Glu Thr Ser Glu Gin 225 230 235 240

Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys 245 250 255

Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu 260 265 (2)序列編號NO·. 604資料： (i) 序列特性： (A) 長度：292胺基酸 (B) 形式：胺基酸 (C) 股數：單

(D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 604

Ala Asn Cys Ser lie Met lie Asp Glu lie He His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125 O:\92\92747.DOC -352- 200413407

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu 145 150 155 160

Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met 165 170 175

Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys 180 185 190

Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys 225 230 235 240

Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Thr Gin Asp 245 250 255

Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie 260 265 270

Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala 275 280 285

Ser Asn Leu Gin 290 (2)序列編號NO: 605資料： (i) 序列特性： (A) 長度：293胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無

(xi)序列描述：序列編號NO: 605

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu 145 150 155 160 O:\92\92747.DOC -353- 200413407

Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met 165 170 175

Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys 180 185 190

Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn 195 200 205

He Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys 210 215 220

Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys 225 230 235 240

Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Thr Gin 245 250 255

Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys 260 265 270 lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val 275 280 285

Ala Ser Asn Leu Gin 290

(2)序列編號NO: 606資料： (i) 序列特性： (A) 長度：296胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 606

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp He Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie He Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr He Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu 145 150 155 160

Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met 165 170 175

Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys 180 185 190 O:\92\92747.DOC -354- 200413407

Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys 225 230 235 240

Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly 245 250 255

Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe 260 265 270

Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro 275 280 285

Val Thr Val Ala Ser Asn Leu Gin 290 295 (2)序列編號NO: 607資料： (i) 序列特性：

(A)長度：299胺基酸 (B )形式：胺基酸 (C) 股數：單 (D) 拓撲結構·線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 607

Ala Asn Cys Ser lie Met He Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro He He lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu 145 150 155 160

Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met 165 170 175

Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys 180 185 190

Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn 195 200 205 lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys 210 215 220 O:\92\92747.DOC -355 200413407

Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys 225 230 235 240

Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly 245 250 255

Gly Gly Ser Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro He Ser 260 265 270

Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin 275 280 285

Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin 290 295 (2)序列編號NO: 608資料： (i) 序列特性： (A) 長度：301胺基酸

(B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 608

Ala Asn Cys Ser lie Met lie Asp Glu He lie His His Leu Lys Arg 1 5 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser

65 70 75 80

Arg His Pro lie lie He Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu 145 150 155 160

Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met 165 170 175

Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys 180 185 190

Pro Trp lie Thr Arg Gin Asn Phe Ser krg Cys Leu Glu Leu Gin Cys 225 230 235 240

Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly 245 250 255 O:\92\92747.DOC -356- 200413407

Gly Gly Ser Gly Gly Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro 260 265 270 lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu 275 280 285

Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin 290 295 300 (2)序列編號NO: 609資料： (i) 序列特性： (A) 長度：307胺基酸 (B) 形式：胺基酸 (C) 股數：單

(D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 609

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly He Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro He He He Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr He Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu 145 150 155 160

Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met 165 170 175

Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys 180 185 190

Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn 195 200 205

He Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys 210 215 220

Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys 225 230 235 240

Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly 245 250 255

Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp Cys 260 265 270

Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg 275 280 285 O:\92\92747.DOC -357- 200413407

Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser 290 295 300

Asn Leu Gin 305 (2)序列編號NO: 610資料： (i) 序列特性： (A) 長度：292胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形

(ii) 分子類型：無 (xi)序列描述：序列編號NO: 610

Ala Asn Cys Ser lie Met lie Asp Glu He He His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Lea Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie He Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu 180 185 190

Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg 195 200 205

Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly 210 215 220

Ser Gly Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser 225 230 235 240

Asp Phe Ala Val Lys He Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp 245 250 255

Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly 260 265 270

Gly Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys 275 280 285

Thr Val Ala Gly 290 O:\92\92747.DOC -358- 200413407 (2)序列編號NO: 611資料： (i) 序列特性： (A) 長度：293胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 611

Ala Asn Cys Ser lie Met He Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu 145 150 155 160

lie His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu 165 170 175

Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu 180 185 190

Gin Leu Val Ala Leu Lys Pro Trp He Thr Arg Gin Asn Phe Ser Arg 195 200 205

Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly 210 215 220

Ser Gly Gly Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser 225 230 235 240

Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin 245 250 255

Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys 260 265 270

Gly Gly Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu 275 280 285

Lys Thr Val Ala Gly 290 (2)序列編號NO: 612資料： O:\92\92747.DOC -359- 200413407 (i) 序列特性： (A) 長度：296胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 612

Ala Asn Cys Ser lie Met lie Asp Glu He lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met

20 25 30

Asp He Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie He lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu 145 150 155 160

He His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu 165 170 175

Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu 180 185 190

Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg 195 200 205

Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly 210 215 220

Ser Gly Gly Gly Ser Gly Gly Thr Gin Asp Cys Ser Phe Gin His Ser 225 230 235 240

Pro He Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr 245 250 255

Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu 260 265 270

Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met 275 280 285

Glu Arg Leu Lys Thr Val Ala Gly 290 295 (2)序列編號NO: 613資料： (i)序列特性： O:\92\92747.DOC 360- 200413407 (A) 長度：299胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 613

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe

35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie He Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He 115 120 125

Ser Thr He Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu 180 185 190

Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg

195 200 205

Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly 210 215 220

Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp Cys Ser Phe 225 230 235 240

Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu 245 250 255

Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 260 265 270

Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 275 280 285

Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly 290 295 (2)序列編號NO: 614資料： (i)序列特性： (A)長度：301胺基酸 O:\92\92747.DOC -361- 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO·. 614

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie He Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr He Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu 180 185 190

Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg 195 200 205

Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly 210 215 220

Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Thr Gin Asp Cys 225 230 235 240

Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg 245 250 255

Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser 260 265 270

Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu 275 280 285

Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly 290 295 300 (2)序列編號NO: 615資料： (i)序列特性： (A) 長度：307胺基酸 (B) 形式：胺基酸 O:\92\92747.DOC -362 200413407 (c)股數：單 (D)拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 615

Ala Asn Cys Ser lie Met He Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly He Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser

65 70 75 80

Arg His Pro He lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu 180 185 190

Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg 195 200 205

Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly 210 215 220

Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly

225 230 235 240

Ser Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp 245 250 255

Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr 260 265 270

Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly 275 280 285

Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr 290 295 300

Val Ala Gly 305 (2)序列編號NO: 616資料： (i)序列特性： (A) 長度：292胺基酸 (B) 形式：胺基酸 O:\92\92747.DOC -363- 200413407 (c)股數：單 (D)拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 616

Ala Asn Cys Ser lie Met lie Asp Glu He lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala'Thr Ala Ala Pro Ser

65 70 75 80

Arg His Pro He lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr He Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser 145 150 155 160

Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp 165 170 175

He Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro 180 185 190

Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Thr Gin Asp Cys Ser 195 200 205

Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu 210 215 220

Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn

225 230 235 240

Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala 245 250 255

Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin 260 265 270

Gly Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys 275 280 285

Ala Phe Gin Pro 290 (2)序列編號NO: 617資料： (i)序列特性： (A) 長度：293胺基酸 (B) 形式：胺基酸 (C) 股數：單 O:\92\92747.DOC -364- 200413407 (D)拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 617

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro He lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser 145 150 155 160

Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Thr Gin Asp Cys 195 200 205

Ser Phe Gin His Ser Pro He Ser Ser Asp Phe Ala Val Lys He Arg 210 215 220

Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser 225 230 235 240

Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu

245 250 255

Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met 260 265 270

Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys 275 280 285

Cys Ala Phe Gin Pro 290 (2)序列編號NO: 618資料： (i)序列特性： (A) 長度：296胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 O:\92\92747.DOC -365- 200413407 (ii)分子類型：無 (xi)序列描述：序列編號NO: 618

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser 145 150 155 160

Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp 165 170 175

He Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro 180 185 190

Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Thr 195 200 205

Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala Val 210 215 220

Lys He Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr 225 230 235 240

Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg 245 250 255

Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly

260 265 270

Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie His Phe 275 280 285

Val Thr Lys Cys Ala Phe Gin Pro 290 295 (2)序列編號NO: 619資料： (i) 序列特性： (A) 長度：299胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 O:\92\92747.DOC -366 200413407 (xi)序列描述：序列編號NO: 619

Ala Asn Cys Ser He Met He Asp Glu He He His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly He Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie He Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser 145 150 155 160

Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 195 200 205

Ser Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp 210 215 220

Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr 225 230 235 240

Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly 245 250 255

Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr 260 265 270

Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu

275 280 285 lie His Phe Val Thr Lys Cys Ala Phe Gin Pro 290 295 (2)序列編號NO: 620資料： (i) 序列特性： (A) 長度：301胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 620 O:\92\92747.DOC -367- 200413407

Ala Asn Cys Ser He Met lie Asp Glu lie lie His His Leu Lys Arg 1 5 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser

145 150 155 160

Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 195 200 205

Ser Gly Gly Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser 210 215 220

Ser Asp Phe Ala Val Lys He Arg Glu Leu Ser Asp Tyr Leu Leu Gin 225 230 235 240

Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys 245 250 255

Gly Gly Leu Trp Arg Leu Yal Leu Ala Gin Arg Trp Met Glu Arg Leu 260 265 270

Lys Thr Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn 275 280 285

Thr Glu He His Phe Val Thr Lys Cys Ala Phe Gin Pro 290 295 300

(2)序列編號NO: 621資料： (i) 序列特性： (A) 長度：307胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 621

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 O:\92\92747.DOC -368 200413407

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie He Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser 145 150 155 160

Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp 165 170 175

He Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro 180 185 190

Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 195 200 205

Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp Cys Ser Phe 210 215 220

Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu 225 230 235 240

Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 245 250 255

Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 260 265 270

Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly 275 280 285

Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala 290 295 300

Phe Gin Pro 305 (2)序列編號NO: 622資料：

(i) 序列特性： (A) 長度：296胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 622

Ala Asn Cys Ser He Met He Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45 O:\92\92747.DOC -369- 200413407

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr He Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu 145 150 155 160

Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met 165 170 175

Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu 180 185 190

Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala Phe Gin Pro

195 200 205

Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu 210 215 220

Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg 225 230 235 240

Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser 245 250 255

Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Thr Gin Asp Cys 260 265 270

Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg 275 280 285

Glu Leu Ser Asp Tyr Leu Leu Gin 290 295 (2)序列編號NO: 623資料： (i) 序列特性：

(A) 長度：301胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 623

Ala Asn Cys Ser lie Met lie Asp Glu lie He His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly He Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 O:\92\92747.DOC -370- 200413407

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu 145 150 155 160

Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met 165 170 175

Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu 180 185 190

Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala Phe Gin Pro 195 200 205

Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu 210 215 220

Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg

225 230 235 240

Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser 245 250 255

Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 260 265 270

Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe 275 280 285

Ala Val Lys He Arg Glu Leu Ser Asp Tyr Leu Leu Gin 290 295 300 (2)序列編號NO: 624資料： (i) 序列特性： (A) 長度：296胺基酸 (B) 形式：胺基酸

(C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO·. 624

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala He 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110 O:\92\92747.DOC -371- 200413407

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu 145 150 155 160

Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val 165 170 175

Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie 180 185 190

His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg 195 200 205

Phe Val Gin Thr Asn He Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin 210 215 220

Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys 225 230 235 240

Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser 245 250 255

Gly Gly Gly Ser Gly Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro 260 265 270 lie Ser Ser Asp Phe Ala Val Lys He Arg Glu Leu Ser Asp Tyr Leu 275 280 285

Leu Gin Asp Tyr Pro Val Thr Val 290 295 (2)序列編號NO: 625資料： (i) 序列特性： (A) 長度：301胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形

(ii) 分子類型：無 (xi)序列描述：序列編號NO: 625

Ala Asn Cys Ser lie Met lie Asp Glu lie He His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala He 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 O:\92\92747.DOC -372- 200413407

Asn Met Ala Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu 145 150 155 160

Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val 165 170 175

Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu He 180 185 190

His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg 195 200 205

Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin 210 215 220

Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys 225 230 235 240

Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser 245 250 255

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Thr Gin Asp Cys Ser 260 265 270

Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys He Arg Glu 275 280 285

Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val 290 295 300 (2)序列編號NO·· 626資料： (i) 序列特性： (A) 長度：296胺基酸 (B) 形式·胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 626

Ala Asn Cys Ser lie Met He Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala He 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie He He Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr He Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val 145 150 155 160

Asn Thr Glu lie His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro 165 170 175 O:\92\92747.DOC -373- 200413407

Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu 180 185 190

Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn 195 200 205

Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu 210 215 220

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Thr Gin Asp Cys Ser Phe 225 230 235 240

Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu 245 250 255

Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 260 265 270

Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 275 280 285

Arg Trp Met Glu Arg Leu Lys Thr 290 295 (2)序列編號NO: 627資料：

(i) 序列特性： (A) 長度：301胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO·. 627

Ala Asn Cys Ser lie Met He Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp He Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie He He Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val 145 150 155 160

Asn Thr Glu lie His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro 165 170 175

Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu 180 185 190

Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn 195 200 205 O:\92\92747.DOC -374. 200413407

Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu 210 215 220

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Thr 225 230 235 240

Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala Val 245 250 255

Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr 260 265 270

Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg 275 280 285

Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr 290 295 300 (2)序列編號NO: 628資料： (i) 序列特性：

(A) 長度：296胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 628

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie He Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu 145 150 155 160

Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn 165 170 175

Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu 180 185 190

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Thr Gin Asp Cys Ser Phe 195 200 205

Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu 210 215 220

Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 225 230 235 240 O:\92\92747.DOC -375- 200413407

Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 245 250 255

Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly 260 265 270

Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala 275 280 285

Phe Gin Pro Pro Pro Ser Cys Leu 290 295 (2)序列編號NO·· 629資料： (i) 序列特性： (A) 長度：301胺基酸 (B) 形式：胺基酸

(C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 629

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie He lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu

85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu 145 150 155 160

Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn 165 170 175

Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu 180 185 190

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Thr 195 200 205

Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala Val 210 215 220

Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr 225 230 235 240

Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg 245 250 255

Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly 260 265 270 O:\92\92747.DOC -376- 200413407

Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie His Phe 275 280 285

Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu 290 295 300 (2)序列編號NO: 630資料： (i) 序列特性· (A) 長度：296胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形

(ii) 分子類型：無 (xi)序列描述：序列編號NO·. 630

Ala Asn Cys Ser He Met lie Asp Glu He lie His His Leu Lys Arg 1 5 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly He Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro He He lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Ser Ser Pro Gly Glu Pro Ser Gly Pro lie

115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin 145 150 155 160

Leu Val Ala Leu Lys Pro Trp He Thr Arg Gin Asn Phe Ser Arg Cys 165 170 175

Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser 180 185 190

Gly Gly Gly Ser Gly Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro 195 200 205

He Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu 210 215 220

Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu 225 230 235 240

Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu 245 250 255

Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg 260 265 270

Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro 275 280 285

Pro Ser Cys Leu Arg Phe Val Gin 290 295 O:\92\92747.DOC -377- 200413407 (2)序列編號NO·. 631資料： (i) 序列特性· (A) 長度：301胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 631

Ala Asn Cys Ser lie Met lie Asp Glu lie He His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp He Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie He Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Thr Asn He Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin

145 150 155 160

Leu Val Ala Leu Lys Pro Trp He Thr Arg Gin Asn Phe Ser Arg Cys 165 170 175

Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser 180 185 190

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Thr Gin Asp Cys Ser 195 200 205

Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu 210 215 220

Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn 225 230 235 240

Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala 245 250 255

Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin 260 265 270

Gly Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys 275 280 285

Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin 290 295 300 (2)序列編號NO: 632資料： O:\92\92747.DOC 378- 200413407 (i) 序列特性： (A) 長度：292胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 632

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 1 5 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp He Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu 145 150 155 160

Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met 165 170 175

Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu 180 185 190

Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala Phe Gin Pro 195 200 205

Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn He Ser Arg Leu Leu 210 215 220

Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg 225 230 235 240

Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser 245 250 255

Thr Leu Gly Gly Gly Ser Gly Gly Thr Gin Asp Cys Ser Phe Gin His 260 265 270

Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser Asp 275 280 285

Tyr Leu Leu Gin 290 (2)序列編號NO: 633資料： (i)序列特性： O:\92\92747.DOC -379- 200413407 (A) 長度：293胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 633

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp He Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly He Glu Ala He 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser'Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu 145 150 155 160

Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met 165 170 175

Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu 180 185 190

Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala Phe Gin Pro 195 200 205

Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu 210 215 220

Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg 225 230 235 240

Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser 245 250 255

Thr Leu Gly Gly Gly Ser Gly Gly Gly Thr Gin Asp Cys Ser Phe Gin 260 265 270

His Ser Pro He Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser 275 280 285

Asp Tyr Leu Leu Gin 290 (2)序列編號NO·· 634資料： (i)序列特性： (A)長度：299胺基酸 O:\92\92747.DOC -380- 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 634

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie

50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro He lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He 115 120 125

Ser Thr He Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu 145 150 155 160

Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met 165 170 175

Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu 180 185 190

Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala Phe Gin Pro 195 200 205

Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu

210 215 220

Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg 225 230 235 240

Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser 245 250 255

Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr 260 265 270

Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala Val 275 280 285

Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin 290 295 (2)序列編號NO: 635資料： (i)序列特性： (A) 長度：307胺基酸 (B) 形式：胺基酸 O:\92\92747.DOC -381- 200413407 (c)股數：單 (D)拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO·. 635

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser

65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val 145 150 155 160

Asn Thr Glu lie His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro 165 170 175

Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu 180 185 190

Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn 195 200 205

Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu 210 215 220

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser

225 230 235 240

Gly Gly Gly Ser Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie 245 250 255

Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu 260 265 270

Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu 275 280 285

Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg 290 295 300

Leu Lys Thr 305 (2)序列編號NO: 636資料： (i)序列特性： (A) 長度：292胺基酸 (B) 形式：胺基酸 O:\92\92747.DOC -382- 200413407 (c)股數：單 (D)拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 636

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly He Glu Ala He 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser

65 70 75 80

Arg His Pro He He lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu 145 150 155 160

Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val 165 170 175

Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie 180 185 190

His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg 195 200 205

Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin 210 215 220

Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys

225 230 235 240

Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser 245 250 255

Gly Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp 260 265 270

Phe Ala Val Lys He Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr 275 280 285

Pro Val Thr Val 290 (2)序列編號NO: 637資料： (i)序列特性： (A) 長度：293胺基酸 (B) 形式：胺基酸 (C) 股數：單 O:\92\92747.DOC 383- 200413407 (D)拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 637

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu

85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu 145 150 155 160

Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val 165 170 175

Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu He 180 185 190

His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg 195 200 205

Phe Val Gin Thr Asn He Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin 210 215 220

Leu Val Ala Leu Lys Pro Trp He Thr Arg Gin Asn Phe Ser Arg Cys 225 230 235 240

Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser

245 250 255

Gly Gly Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro He Ser Ser 260 265 270

Asp Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp 275 280 285

Tyr Pro Val Thr Val 290 (2)序列編號NO: 638資料： (i)序列特性： (A) 長度：299胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 O:\92\92747.DOC -384- 200413407 (ii)分子類型：無 (xi)序列描述：序列編號NO: 638

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly He Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro He lie He Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu 145 150 155 160

Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val 165 170 175

Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie 180 185 190

His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg 195 200 205

Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin 210 215 220

Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys 225 230 235 240

Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser 245 250 255

Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp Cys Ser Phe Gin

260 265 270

His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser 275 280 285

Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val 290 295 (2)序列編號NO: 639資料： (i) 序列特性： (A) 長度：307胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 O:\92\92747.DOC 385- 200413407 (xi)序列描述：序列編號NO: 639

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie He Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu 145 150 155 160

Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val 165 170 175

Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie 180 185 190

His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg 195 200 205

Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin 210 215 220

Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys 225 230 235 240

Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser 245 250 255

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 260 265 270

Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe 275 280 285

Ala Val Lys He Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro 290 295 300

Val Thr Val 305 (2)序列編號NO: 640資料： (i)序列特性： (A) 長度：292胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (Π)分子類型：無 O:\92\92747.DOC -386- 200413407 (xi)序列描述：序列編號NO: 640

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala He 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val 145 150 155 160

Asn Thr Glu lie His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro 165 170 175

Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu 180 185 190

Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn 195 200 205

Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu 210 215 220

Gly Gly Gly Ser Gly Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro 225 230 235 240 lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu 245 250 255

Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu 260 265 270

Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu 275 280 285

Arg Leu Lys Thr 290 (2)序列編號NO: 641資料： (i) 序列特性： (A) 長度：293胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 641 O:\92\92747.DOC -387 200413407

Ala Asn Cys Ser lie Met lie Asp Glu He lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie He Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr He Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val

145 150 155 160

Asn Thr Glu lie His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro 165 170 175

Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu 180 185 190

Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn 195 200 205

Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu 210 215 220

Gly Gly Gly Ser Gly Gly Gly Thr Gin Asp Cys Ser Phe Gin His Ser 225 230 235 240

Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr 245 250 255

Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu 260 265 270

Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met 275 280 285

Glu Arg Leu Lys Thr 290

(2)序列編號NO·. 642資料： (i) 序列特性： (A) 長度：299胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 642

Ala Asn Cys Ser lie Met lie Asp Glu lie He His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 O:\92\92747.DOC -388- 200413407

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val 145 150 155 160

Asn Thr Glu He His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro 165 170 175

Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu

180 185 190

Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp He Thr Arg Gin Asn 195 200 205

Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu 210 215 220

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp 225 230 235 240

Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie 245 250 255

Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala 260 265 270

Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val 275 280 285

Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr 290 295 (2)序列編號NO: 643資料：

(i) 序列特性： (A) 長度：307胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 643

Ala Asn Cys Ser He Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala He 50 55 60 O:\92\92747.DOC -389- 200413407

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr He Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val 145 150 155 160

Asn Thr Glu lie His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro 165 170 175

Ser Cys Leu Arg Phe Val Gin Thr Asn He Ser Arg Leu Leu Gin Glu 180 185 190

Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn 195 200 205

Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu 210 215 220

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 225 230 235 240

Gly Gly Gly Ser Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro He 245 250 255

Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu 260 265 270

Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu 275 280 285

Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg 290 295 300

Leu Lys Thr 305 (2)序列編號NO·· 644資料： (i) 序列特性：

(A) 長度：292胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 644

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly He Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 O:\92\92747.DOC -390- 200413407

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Arg Phe Val Gin Thr Asn He Ser Arg Leu Leu Gin Glu 145 150 155 160

Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn 165 170 175

Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu 180 185 190

Gly Gly Gly Ser Gly Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro 195 200 205

He Ser Ser Asp Phe Ala Val Lys He Arg Glu Leu Ser Asp Tyr Leu 210 215 220

Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu

225 230 235 240

Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu 245 250 255

Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg 260 265 270

Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro 275 280 285

Pro Ser Cys Leu 290 (2)序列編號NO: 645資料： (i)序列特性： (A) 長度：293胺基酸 (B) 形式：胺基酸

(C) 股數：單 (D) 拓撲結構：線形 (Π)分子類型：無 (xi)序列描述：序列編號NO: 645

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro He lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110 O:\92\92747.DOC -391- 200413407

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu 145 150 155 160

Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn 165 170 175

Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu 180 185 190

Gly Gly Gly Ser Gly Gly Gly Thr Gin Asp Cys Ser Phe Gin His Ser 195 200 205

Pro He Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr 210 215 220

Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu 225 230 235 240

Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met 245 250 255

Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu 260 265 270

Arg Val Asn Thr Glu He His Phe Val Thr Lys Cys Ala Phe Gin Pro 275 280 285

Pro Pro Ser Cys Leu 290 (2)序列編號NO: 646資料： (i) 序列特性： (A) 長度：299胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形

(ii) 分子類型：無 (xi)序列描述：序列編號NO: 646

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp He Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro He lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140 O:\92\92747.DOC -392 200413407

Asn Met Ala Arg Phe Val Gin Thr Asn He Ser Arg Leu Leu Gin Glu 145 150 155 160

Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn 165 170 175

Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu 180 185 190

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp 195 200 205

Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie 210 215 220

Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala 225 230 235 240

Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val 245 250 255

Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys 260 265 270

Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu He His Phe Val Thr 275 280 285

Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu 290 295 (2)序列編號NO: 647資料： (i) 序列特性： (A) 長度：307胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 647

Ala Asn Cys Ser He Met lie Asp Glu lie lie His His Leu Lys Arg 1 5 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp He Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro He lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu 145 150 155 160

Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp He Thr Arg Gin Asn 165 170 175 O:\92\92747.DOC -393- 200413407

Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu 180 185 190

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 195 200 205

Gly Gly Gly Ser Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie 210 215 220

Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu 225 230 235 240

Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu 245 250 255

Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg 260 265 270

Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val 275 280 285

Asn Thr Glu lie His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro 290 295 300

Ser Cys Leu 305

(2)序列編號NO: 648資料： (i) 序列特性： (A) 長度：292胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 648

Ala Asn Cys Ser He Met lie Asp Glu He lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala He 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro He He lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Ser Ser Pro Gly Glu Pro Ser Gly Pro He 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin 145 150 155 160

Leu Val Ala Leu Lys Pro Trp He Thr Arg Gin Asn Phe Ser Arg Cys 165 170 175

Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser 180 185 190 O:\92\92747.DOC 394 200413407

Gly Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp 195 200 205

Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr 210 215 220

Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly 225 230 235 240

Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr 245 250 255

Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu 260 265 270 lie His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu 275 280 285

Arg Phe Val Gin 290 (2)序列編號NO: 649資料：

(i)序列特性： (A) 長度：293胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (Π)分子類型：無 (xi)序列描述：序列編號NO: 649

Ala Asn Cys Ser lie Met He Asp Glu He He His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala He 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Ser Ser Pro Gly Glu Pro Ser Gly Pro He 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin 145 150 155 160

Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys 165 170 175

Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser 180 185 190

Gly Gly Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro He Ser Ser 195 200 205

Asp Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp 210 215 220 O:\92\92747.DOC -395- 200413407

Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly 225 230 235 240

Gly Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys 245 250 255

Thr Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr 260 265 270

Glu lie His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys 275 280 285

Leu Arg Phe Val Gin 290 (2)序列編號NO: 650資料： (i)序列特性： (A) 長度：299胺基酸

(B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (Π)分子類型：無 (xi)序列描述：序列編號NO: 650

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala He 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser

65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Ser Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin 145 150 155 160

Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys 165 170 175

Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser 180 185 190

Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp Cys Ser Phe Gin 195 200 205

His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser 210 215 220

Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin 225 230 235 240

Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin Arg O:\92\92747.DOC -396- 200413407 245 250 255

Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly Leu 260 265 270

Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala Phe 275 280 285

Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin 290 295 (2)序列編號NO: 651資料： (i) 序列特性： (A) 長度：307胺基酸 (B) 形式·胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 651

Ala Asn Cys Ser lie Met lie Asp Glu He lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro He lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin 145 150 155 160

Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys 165 170 175

Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser 180 185 190

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 195 200 205

Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe 210 215 220

Ala Val Lys He Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro 225 230 235 240

Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu 245 250 255

Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val 260 265 270

Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie -397-

O:\92\92747.DOC 200413407 275 280 285

His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg 290 295 300

Phe Val Gin 305 (2)序列編號NO: 652資料： (i) 序列特性： (A) 長度：749胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形

(ii) 分子類型：無 (xi)序列描述：序列編號NO: 652

Gly Ser Thr Met Ser Arg Leu Pro Val Leu Leu Leu Leu Gin Leu Leu 15 10 15

Val Arg Pro Ala Met Ser Thr Asn Gin Asp Leu Pro Val lie Lys Cys 20 25 30

Val Leu He Asn His Lys Asn Asn Asp Ser Ser Val Gly Lys Ser Ser 35 40 45

Ser Tyr Pro Met Val Ser Glu Ser Pro Glu Asp Leu Gly Cys Ala Leu 50 55 60

Arg Pro Gin Ser Ser Gly Thr Val Tyr Glu Ala Ala Ala Val Glu Val 65 70 75 80

Asp Val Ser Ala Ser lie Thr Leu Gin Val Leu Val Asp Ala Pro Gly 85 90 95

Asn He Ser Cys Leu Trp Val Phe Lys His Ser Ser Leu Asn Cys Gin 100 105 110

Pro His Phe Asp Leu Gin Asn Arg Gly Val Val Ser Met Val He Leu 115 120 125

Lys Met Thr Glu Thr Gin Ala Gly Glu Tyr Leu Leu Phe lie Gin Ser 130 135 140

Glu Ala Thr Asn Tyr Thr He Leu Phe Thr Val Ser lie Arg Asn Thr 145 150 155 160

Leu Leu Tyr Thr Leu Arg Arg Pro Tyr Phe Arg Lys Met Glu Asn Gin 165 170 175

Asp Ala Leu Val Cys lie Ser Glu Ser Val Pro Glu Pro He Val Glu 180 185 190

Trp Val Leu Cys Asp Ser Gin Gly Glu Ser Cys Lys Glu Glu Ser Pro 195 200 205

Ala Val Val Lys Lys Glu Glu Lys Val Leu His Glu Leu Phe Gly Met 210 215 220

Asp lie Arg Cys Cys Ala Arg Asn Glu Leu Gly Arg Glu Cys Thr Arg 225 230 235 240

Leu Phe Thr lie Asp Leu Asn Gin Thr Pro Gin Thr Thr Leu Pro Gin 245 250 255

Leu Phe Leu Lys Val Gly Glu Pro Leu Trp lie Arg Cys Lys Ala Val 260 265 270

His Val Asn His Gly Phe Gly Leu Thr Trp Glu Leu Glu Asn Lys Ala 275 280 285

Leu Glu Glu Gly Asn Tyr Phe Glu Met Ser Thr Tyr Ser Thr Asn Arg O:\92\92747.DOC -398 200413407 290 295 300

Thr Met lie Arg lie Leu Phe Ala Phe Val Ser Ser Val Ala Arg Asn 305 310 315 320

Asp Thr Gly Tyr Tyr Thr Cys Ser Ser Ser Lys His Pro Ser Gin Ser 325 330 335

Ala Leu Val Thr lie Val Glu Lys Gly Phe He Asn Ala Thr Asn Ser 340 345 350

Ser Glu Asp Tyr Glu He Asp Gin Tyr Glu Glu Phe Cys Phe Ser Val 355 360 365

Arg Phe Lys Ala Tyr Pro Gin He Arg Cys Thr Trp Thr Phe Ser Arg 370 375 380

Lys Ser Phe Pro Cys Glu Gin Lys Gly Leu Asp Asn Gly Tyr Ser lie 385 390 395 400

Ser Lys Phe Cys Asn His Lys His Gin Pro Gly Glu Tyr lie Phe His 405 410 415

Ala Glu Asn Asp Asp Ala Gin Phe Thr Lys Met Phe Thr Leu Asn lie 420 425 430

Arg Arg Lys Pro Gin Val Leu Ala Glu Ala Ser Ala Ser Gin Ala Ser 435 440 445

Cys Phe Ser Asp Gly Tyr Pro Leu Pro Ser Trp Thr Trp Lys Lys Cys 450 455 460

Ser Asp Lys Ser Pro Asn Cys Thr Glu Glu lie Thr Glu Gly Val Trp 465 470 475 480

Asn Arg Lys Ala Asn Arg Lys Val Phe Gly Gin Trp Val Ser Ser Ser 485 490 495

Thr Leu Asn Met Ser Glu Ala lie Lys Gly Phe Leu Val Lys Cys Cys 500 505 510

Ala Tyr Asn Ser Leu Gly Thr Ser Cys Glu Thr lie Leu Leu Asn Ser 515 520 525

Pro Gly Pro Phe Pro Phe lie Gin Asp Asn Glu Phe lie lie Leu Gly 530 535 540

Leu Phe Gly Leu Leu Leu Leu Leu Thr Cys Leu Cys Gly Thr Ala Trp 545 550 555 560

Leu Cys Cys Ser Pro Asn Arg Lys Asn Pro Leu Trp Pro Ser Val Pro 565 570 575

Asp Pro Ala His Ser Ser Leu Gly Ser Trp Val Pro Thr lie Met Glu 580 585 590

Glu Asp Ala Phe Gin Leu Pro Gly Leu Gly Thr Pro Pro lie Thr Lys 595 600 605

Leu Thr Val Leu Glu Glu Asp Glu Lys Lys Pro Val Pro Trp Glu Ser 610 615 620

His Asn Ser Ser Glu Thr Cys Gly Leu Pro Thr Leu Val Gin Thr Tyr 625 630 635 640

Val Leu Gin Gly Asp Pro Arg Ala Val Ser Thr Gin Pro Gin Ser Gin 645 650 655

Ser Gly Thr Ser Asp Gin Val Leu Tyr Gly Gin Leu Leu Gly Ser Pro 660 665 670

Thr Ser Pro Gly Pro Gly His Tyr Leu Arg Cys Asp Ser Thr Gin Pro 675 680 685

Leu Leu Ala Gly Leu Thr Pro Ser Pro Lys Ser Tyr Glu Asn Leu Trp 690 695 700

Phe Gin Ala Ser Pro Leu Gly Thr Leu Val Thr Pro Ala Pro Ser Gin 705 710 715 720

Glu Asp Asp Cys Val Phe Gly Pro Leu Leu Asn Phe Pro Leu Leu Gin 725 730 735

Gly lie Arg Val His Gly Met Glu Ala Leu Gly Ser Phe 740 745 (2)序列編號NO: 653資料： O:\92\92747.DOC 399 200413407 (i) 序列特性： (A) 長度：349胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 653

Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser Phe Leu Leu 15 10 15

Lys Ser Leu Glu Gin Val Arg Lys He Gin Gly Asp Gly Ala Ala Leu

20 25 30

Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 35 40 45

Val Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser 50 55 60

Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His 65 70 75 80

Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie 85 90 95

Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala 100 105 110

Asp Phe Ala Thr Thr lie Trp Gin Gin Met Glu Glu Leu Gly Met Ala 115 120 125

Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala 130 135 140

Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser 145 150 155 160

Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro Tyr 165 170 175

Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie Ser 180 185 190

Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn 195 200 205

Met Ala Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp 210 215 220

Phe Ala Val Lys He Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr 225 230 235 240

Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly 245 250 255

Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr 260 265 270

Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu 275 280 285

He His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu 290 295 300

Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu 305 310 315 320

Gin Leu Val Ala Leu Lys Pro Trp He Thr Arg Gin Asn Phe Ser Arg 325 330 335

Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu 340 345 O:\92\92747.DOC -400- 200413407 (2)序列編號NO: 654資料： (i) 序列特性： (A) 長度：314胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 654

Ala Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe 15 10 15

Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro 20 25 30

Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu 35 40 45

Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val 50 55 60

Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie 65 70 75 80

His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg 85 90 95

Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin 100 105 110

Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys 115 120 125

Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Tyr Val Glu Gly 130 135 140

Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie Ser Thr lie Asn 145 150 155 160

Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Thr 165 170 175

Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala Val 180 185 190

Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr 195 200 205

Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg 210 215 220

Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly 225 230 235 240

Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie His Phe 245 250 255

Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val 260 265 270

Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val 275 280 285

Ala Leu Lys Pro Trp He Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu 290 295 300

Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu 305 310 O:\92\92747.DOC -401- 200413407 (2)序列編號NO: 655資料： (i) 序列特性： (A) 長度：349胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 655

Ala Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe 15 10 15

Ala Val Lys He Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro 20 25 30

Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu 35 40 45

Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val 50 55 60

Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie 65 70 75 80

His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg 85 90 95

Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin 100 105 110

Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys 115 120 125

Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Tyr Val Glu Gly 130 135 140

Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie Ser Thr lie Asn 145 150 155 160

Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Thr 165 170 175

Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser Phe Leu Leu Lys Cys 180 '185 190

Leu Glu Gin Val Arg Lys lie Gin Gly Asp Gly Ala Ala Leu Gin Glu 195 200 205

Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu 210 215 220

Leu Gly His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys Pro 225 230 235 240

Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser Gly 245 250 255

Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie Ser Pro 260 265 270

Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala Asp Phe 275 280 285

Ala Thr Thr lie Trp Gin Gin Met Glu Glu Leu Gly Met Ala Pro Ala 290 295 300

Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gin 305 310 315 320

Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser Phe Leu 325 330 335

Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro O:\92\92747.DOC -402- 200413407 340 345 (2)序列編號NO: 656資料： (i) 序列特性： (A) 長度：523胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 656

Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser Phe Leu Leu 15 10 15

Lys Ser Leu Glu Gin Val Arg Lys lie Gin Gly Asp Gly Ala Ala Leu 20 25 30

Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 35 40 45

Val Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser 50 55 60

Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His 65 70 75 80

Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie 85 90 95

Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala 100 105 110

Asp Phe Ala Thr Thr He Trp Gin Gin Met Glu Glu Leu Gly Met Ala 115 120 125

Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala 130 135 140

Phe Gin krg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser 145 150 155 160

Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro Tyr 165 170 175

Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He Ser 180 185 190

Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn 195 200 205

Met Ala Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp 210 215 220

Phe Ala Val Lys He Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr 225 230 235 240

Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly 245 250 255

Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr 260 265 270

Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu 275 280 285 lie His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu 290 295 300

Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu 305 310 315 320 O:\92\92747.DOC -403- 200413407

Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg 325 330 335

Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Tyr Val Glu 340 345 350

Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie Ser Thr lie 355 360 365

Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala 370 375 380

Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala 385 390 395 400

Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val 405 410 415

Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp 420 425 430

Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala 435 440 445

Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu He His 450 455 460

Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe

465 470 475 480

Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu 485 490 495

Val Ala Leu Lys Pro Trp He Thr Arg Gin Asn Phe Ser Arg Cys Leu 500 505 510

Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu 515 520 (2)序列編號NO: 657資料： (i) 序列特性： (A) 長度：460胺基酸 (B) 形式：胺基酸 (C) 股數：單

(D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 657

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30

Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45

Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly He Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie He Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125 O:\92\92747.DOC -404- 200413407

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser 145 150 155 160

Asp Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp 165 170 175

Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly 180 185 190

Gly Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys 195 200 205

Thr Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr 210 215 220

Glu lie His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys 225 230 235 240

Leu Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser 245 250 255

Glu Gin Leu Val Ala Leu Lys Pro Trp He Thr Arg Gin Asn Phe Ser 260 265 270

Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Tyr Val 275 280 285

Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie Ser Thr 290 295 300

He Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met 305 310 315 320

Ala Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe 325 330 335

Ala Val Lys He Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro 340 345 350

Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu 355 360 365

Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val 370 375 380

Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie 385 390 395 400

His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg 405 410 415

Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin 420 425 430

Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys 435 440 445

Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu 450 455 460 (2)序列編號NO·. 658資料： (i)序列特性： (A) 長度：523胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (Π)分子類型：無 (xi)序列描述：序列編號NO: 658 O:\92\92747.DOC -405- 200413407

Ala Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe 15 10 15

Ala Val Lys He Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro 20 25 30

Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu 35 40 45

Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val 50 55 60

Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie 65 70 75 80

His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg 85 90 95

Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin 100 105 110

Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys 115 120 125

Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Tyr Val Glu Gly 130 135 140

Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie Ser Thr He Asn

145 150 155 160

Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Thr 165 170 175

Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser Phe Leu Leu Lys Ser 180 185 190

Leu Glu Gin Val Arg Lys lie Gin Gly Asp Gly Ala Ala Leu Gin Glu 195 200 205

Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu 210 215 220

Leu Gly His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys Pro 225 230 235 240

Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser Gly 245 250 255

Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie Ser Pro 260 265 270

Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala Asp Phe 275 280 285

Ala Thr Thr lie Trp Gin Gin Met Glu Glu Leu Gly Met Ala Pro Ala 290 295 300

Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gin

305 310 315 320

Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser Phe Leu 325 330 335

Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro Tyr Val Glu 340 345 350

Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie Ser Thr lie 355 360 365

Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala 370 375 380

Thr Gin Asp Cys Ser Phe Gin His Ser Pro He Ser Ser Asp Phe Ala 385 390 395 400

Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val 405 410 415

Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp 420 425 430

Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala 435 440 445

Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie His 450 455 460

Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe 465 470 475 480

Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu O:\92\92747.DOC •406- 200413407 485 490 495

Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys Leu 500 505 510

Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu 515 520 (2)序列編號NO: 659資料： (i) 序列特性： (A) 長度：334胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形

(ii) 分子類型：無 (xi)序列描述：序列編號NO: 659

Ala Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe 1 5 10 15

Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro 20 25 30

Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu 35 40 45

Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val 50 55 60

Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie 65 70 75 80

His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg 85 90 95

Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin 100 105 110

Leu Val Ala Leu Lys Pro Trp He Thr Arg Gin Asn Phe Ser Arg Cys 115 120 125

Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Tyr Val Glu Gly 130 135 140

Gly Gly Gly Ser Pro Gly Gly Gly Ser Gly Gly Gly Ser Asn Met Ala 145 150 155 160

Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser Phe Leu Leu Lys 165 170 175

Ser Leu Glu Gin Val Arg Lys lie Gin Gly Asp Gly Ala Ala Leu Gin 180 185 190

Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val 195 200 205

Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys 210 215 220

Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser 225 230 235 240

Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie Ser 245 250 255

Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala Asp 260 265 270

Phe Ala Thr Thr lie Trp Gin Gin Met Glu Glu Leu Gly Met Ala Pro 275 280 285

Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Phe O:\92\92747.DOC -407- 200413407 290 295 300

Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser Phe 305 310 315 320

Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro 325 330 (2)序列編號NO: 660資料： (i) 序列特性： (A) 長度：296胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形

(ii) 分子類型：無 (xi)序列描述：序列編號NO: 660

Ala Asn Cys Ser He Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala He 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie He He Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr He Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu 145 150 155 160

Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met 165 170 175

Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu 180 185 190

Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala Phe Gin Pro 195 200 205

Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu 210 215 220

Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg 225 230 235 240

Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser 245 250 255

Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Thr Gin Asp Cys 260 265 270

Ser Phe Gin His Ser Pro He Ser Ser Asp Phe Ala Val Lys lie Arg 275 280 285

Glu Leu Ser Asp Tyr Leu Leu Gin O:\92\92747.DOC -408- 295 290 (2)序列編號NO: 661資料： (i) 序列特性： (A) 長度：301胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 661

Ala Asn Cys Ser He Met lie Asp Glu lie He His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala He 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie He lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu 145 150 155 160

Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met 165 170 175

Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu 180 185 190

Arg Val Asn Thr Glu He His Phe Val Thr Lys Cys Ala Phe Gin Pro 195 200 205

Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu 210 215 220

Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg 225 230 235 240

Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser 245 250 255

Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 260 265 270

Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro He Ser Ser Asp Phe 275 280 285

Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin 290 295 300 -409-

O:\92\92747.DOC 200413407 (2)序列編號NO: 662資料： (i) 序列特性： (A) 長度：296胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 662

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp He Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie He Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu 145 150 155 160

Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val 165 170 175

Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie 180 185 190

His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg 195 200 205

Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin 210 215 220

Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys 225 230 235 240

Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser 245 250 255

Leu Gin Asp Tyr Pro Val Thr Val 290 295 (2)序列編號NO: 663資料： O:\92\92747.DOC -410- 200413407 (i) 序列特性： (A) 長度：301胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 663

Ala Asn Cys Ser lie Met lie Asp Glu He lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu 145 150 155 160

Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val 165 170 175

Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu He 180 185 190

His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg 195 200 205

Phe Val Gin Thr Asn He Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin 210 215 220

Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys 225 230 235 240

Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser 245 250 255

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Thr Gin Asp Cys Ser 260 265 270

Phe Gin His Ser Pro He Ser Ser Asp Phe Ala Val Lys lie Arg Glu 275 280 285

Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val 290 295 300 (2)序列編號NO: 664資料： (i)序列特性· O:\92\92747.DOC -411- 200413407 (A) 長度：296胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 664

Ala Asn Cys Ser lie Met He Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp He Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala He 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro He He He Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val 145 150 155 160

Asn Thr Glu He His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro 165 170 175

Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu 180 185 190

Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn 195 200 205

Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu 210 215 220

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Thr Gin Asp Cys Ser Phe 225 230 235 240

Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu 245 i 250 255

Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 260 265 270

Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 275 280 285

Arg Trp Met Glu Arg Leu Lys Thr 290 295 (2)序列編號NO: 665資料： (i)序列特性： (A)長度：301胺基酸 O:\92\92747.DOC -412- 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 665

Ala Asn Cys Ser He Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro He He lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He 115 120 125

Ser Thr He Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val 145 150 155 160

Asn Thr Glu lie His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro 165 170 175

Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu 180 185 190

Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn 195 200 205

Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu 210 215 220

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Thr 225 230 235 240

Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala Val 245 250 255

Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr 260 265 270

Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg 275 280 285

Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr 290 295 300 (2)序列編號NO: 666資料： (i)序列特性： (A) 長度：296胺基酸 (B) 形式：胺基酸 O:\92\92747.DOC -413- (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 666

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly He Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie He lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Arg Phe Val Gin Thr Asn He Ser Arg Leu Leu Gin Glu 145 150 155 160

Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn 165 170 175

Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu 180 185 190

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Thr Gin Asp Cys Ser Phe 195 200 205

Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys He Arg Glu Leu 210 215 220

Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 225 230 235 240

Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 245 250 255

Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly 260 265 270

Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala 275 280 285

Phe Gin Pro Pro Pro Ser Cys Leu 290 295 (2)序列編號NO: 667資料： (i)序列特性： (A) 長度：301胺基酸 (B) 形式：胺基酸 (C) 股數：單 -414-

O:\92\92747.DOC 200413407 (D)拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 667

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp He Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly He Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu

85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr He Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Arg Phe Val Gin Thr Asn He Ser Arg Leu Leu Gin Glu 145 150 155 160

Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn 165 170 175

Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu 180 185 190

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Thr 195 200 205

Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala Val 210 215 220

Lys He Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr 225 230 235 240

Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg

245 250 255

Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly 260 265 270

Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu He His Phe 275 280 285

Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu 290 295 300 (2)序列編號NO: 668資料： (i)序列特性： (A) 長度：296胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 O:\92\92747.DOC 415- 200413407 (ii)分子類型：無 (xi)序列描述：序列編號NO.· 668

Ala Asn Cys Ser lie Met lie Asp Glu lie He His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp He Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin

100 105 110

Tyr Val Glu Gly Gly Gly Ser Ser Pro Gly Glu Pro Ser Gly Pro He 115 120 125

Ser Thr He Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin 145 150 155 160

Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys 165 170 175

Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser 180 185 190

Gly Gly Gly Ser Gly Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro 195 200 205 lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu 210 215 220

Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu 225 230 235 240

Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu 245 250 255

Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg

260 265 270

Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro 275 280 285

Pro Ser Cys Leu Arg Phe Val Gin 290 295 (2)序列編號NO: 669資料： (i) 序列特性： (A) 長度：301胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 O:\92\92747.DOC -416- 200413407 (xi)序列描述：序列編號NO: 669

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly He Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie He Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr He Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin 145 150 155 160

Leu Val Ala Leu Lys Pro Trp He Thr Arg Gin Asn Phe Ser Arg Cys 165 170 175

Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser 180 185 190

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Thr Gin Asp Cys Ser 195 200 205

Phe Gin His Ser Pro He Ser Ser Asp Phe Ala Val Lys lie Arg Glu 210 215 220

Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn 225 230 235 240

Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala 245 250 255

Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin 260 265 270

Gly Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys 275 280 285

Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin 290 295 300 (2)序列編號NO: 670資料： (i)序列特性： (A) 長度：307胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (Π)分子類型：無 (xi)序列描述：序列編號NO: 670 O:\92\92747.DOC -417- 200413407

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly He Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie He Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He 115 120 125

Ser Thr He Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp

145 150 155 160

Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala 165 170 175

Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie His 180 185 190

Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe 195 200 205

Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu 210 215 220

Val Ala Leu Lys Pro Trp He Thr Arg Gin Asn Phe Ser Arg Cys Leu 225 230 235 240

Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly 245 250 255

Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 260 265 270

Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala 275 280 285

Val Lys He Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val 290 295 300

Thr Val Ala 305 (2)序列編號NO: 671資料： (i) 序列特性： (A) 長度：307胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 671

Ala Asn Cys Ser lie Met lie Asp Glu lie He His His Leu Lys Arg O:\92\92747.DOC -418- 200413407 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala He 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro He lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg 145 150 155 160

Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly 165 170 175

Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie His Phe 180 185 190

Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val 195 200 205

Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val 210 215 220

Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu 225 230 235 240

Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly 245 250 255

Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr 260 265 270

Gin Asp Cys Ser Phe Gin His Ser Pro He Ser Ser Asp Phe Ala Val 275 280 285

Lys He Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr 290 295 300

Val Ala Ser 305

(2)序列編號NO: 672資料： (i) 序列特性： (A) 長度：307胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 672

Ala Asn Cys Ser He Met He Asp Glu He He His His Leu Lys Arg 15 10 15 O:\92\92747.DOC -419- 200413407

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu 145 150 155 160

Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser

165 170 175

Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu He His Phe Val 180 185 190

Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin 195 200 205

Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala 210 215 220

Leu Lys Pro Trp He Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu 225 230 235 240

Gin Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly 245 250 255

Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin 260 265 270

Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys 275 280 285

He Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val 290 295 300

Ala Ser Asn 305

(2)序列編號NO·. 673資料： (i) 序列特性： (A) 長度：307胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 673

Ala Asn Cys Ser lie Met He Asp Glu He He His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30 O:\92\92747.DOC -420- 200413407

Asp He Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala He 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val 145 150 155 160

Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys 165 170 175

Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr 180 185 190

Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr 195 200 205

Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu 210 215 220

Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin 225 230 235 240

Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser 245 250 255

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp 260 265 270

Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie 275 280 285

Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala 290 295 300

Ser Asn Leu 305 (2)序列編號NO: 674資料：

(i) 序列特性： (A) 長度：305胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 674

Ala Asn Cys Ser lie Met He Asp Glu lie He His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp He Leu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg 35 40 45 O:\92\92747.DOC -421- 200413407

Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala He Leu Arg 50 55 60

Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His 65 70 75 80

Pro lie lie He Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu Lys Leu 85 90 95

Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin Tyr Val 100 105 110

Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie Ser Thr 115 120 125

He Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met 130 135 140

Ala Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin Arg 145 150 155 160

Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly Leu 165 170 175

Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala Phe 180 185 190

Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn He Ser Arg 195 200 205

Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp lie 210 215 220

Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp 225 230 235 240

Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 245 250 255

Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp Cys Ser Phe Gin 260 265 270

His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser 275 280 285

Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin 290 295 300

Asp 305 (2)序列編號NO: 675資料：

(i) 序列特性： (A) 長度：307胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 675

Ala Asn Cys Ser lie Met He Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly He Glu Ala lie 50 55 60 O:\92\92747.DOC -422- 200413407

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 145 150 155 160

Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly 165 170 175

Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala 180 185 190

Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser 195 200 205

Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp 210 215 220 lie Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro 225 230 235 240

Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 245 250 255

Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp Cys Ser Phe 260 265 270

Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu 275 280 285

Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 290 295 300

Gin Asp Glu 305 (2)序列編號NO·· 676資料： (i) 序列特性：

(A) 長度：307胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 676

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 1 5 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Vai Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80 O:\92\92747.DOC -423- 200413407

Arg His Pro lie lie He Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr He Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin Arg 145 150 155 160

Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly Leu 165 170 175

Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala Phe 180 185 190

Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser Arg 195 200 205

Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp lie 210 215 220

Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp

225 230 235 240

Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 245 250 255

Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp Cys Ser Phe Gin 260 265 270

His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser 275 280 285

Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin 290 295 300

Asp Glu Glu 305 (2)序列編號NO: 677資料： (i) 序列特性： (A) 長度：307胺基酸

(B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 677

Ala Asn Cys Ser He Met He Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala He 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie He lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95 O:\92\92747.DOC •424- 200413407

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr He Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp 145 150 155 160

Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala 165 170 175

Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu He His 180 185 190

Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe 195 200 205

Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu 210 215 220

Val Ala Leu Lys Pro Trp He Thr Arg Gin Asn Phe Ser Arg Cys Leu 225 230 235 240

Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly 245 250 255

Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 260 265 270

Thr Gin Asp Cys Ser Phe Gin His Ser Pro He Ser Ser Asp Ser Ala 275 280 285

Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val 290 295 300

Thr Val Ala 305 (2)序列編號NO: 678資料： (i) 序列特性： (A) 長度：307胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 678

Ala Asn Cys Ser lie Met He Asp Glu lie He His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie He lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110 -425-

O:\92\92747.DOC

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val 145 150 155 160

Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys 165 170 175

Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr 180 185 190

Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr 195 200 205

Asn He Ser Arg Leu Leu Arg Glu Thr Ser Glu Gin Pro Val Ala Leu 210 215 220

Lys Pro Trp He Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin 225 230 235 240

Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser 245 250 255

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp 260 265 270

Cys Ser Phe Gin His Ser Pro He Ser Ser Asp Phe Ala Val Lys lie 275 280 285

Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala 290 295 300

Ser Asn Leu 305 (2)序列編號NO: 679資料： (i) 序列特性： (A) 長度：307胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 679

Ala Asn Cys Ser He Met lie Asp Glu He He His His Leu Lys Arg 15 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala He 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro He lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He 115 120 125 -426-

O:\92\92747.DOC

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin Arg 145 150 155 160

Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly Leu 165 170 175

Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala Phe 180 185 190

Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser Arg 195 200 205

Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp lie 210 215 220

Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Arg Pro Asp 225 230 235 240

Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 245 250 255

Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp Cys Ser Phe Gin 260 265 270

His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser 275 280 285

Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin 290 295 300

Asp Glu Glu 305 (2)序列編號NO: 680資料： (i) 序列特性： (A) 長度：302胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 680

Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 15 10 15

Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly 20 25 30

Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala 35 40 45

Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser 50 55 60

Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 100 105 110

Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp Cys Ser Phe 115 120 125

Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu 427-

O:\92\92747.DOC 200413407 130 135 140

Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Tyr Val Glu Gly 145 150 155 160

Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie Ser Thr He Asn 165 170 175

Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Asn 180 185 190

Cys Ser lie Met He Asp Glu lie lie His His Leu Lys Arg Pro Pro 195 200 205

Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met Asp lie 210 215 220

Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg 225 230 235 240

Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie Leu Arg 245 250 255

Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His 260 265 270

Pro lie lie He Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu Lys Leu 275 280 285

Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 290 295 300 (2)序列編號NO: 681資料： (i) 序列特性： (A) 長度：296胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO·. 681

Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 15 10 15

Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly 20 25 30

Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala 35 40 45

Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser 50 55 60

Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Arg Pro Trp 65 70 75 80 lie Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro 85 90 95

Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Thr 100 105 110

Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala Val 115 120 125

Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr 130 135 140

Val Ala Ser Asn Leu Gin Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly 145 150 155 160

Glu Pro Ser Gly Pro He Ser Thr lie Asn Pro Ser Pro Pro Ser Lys O:\92\92747.DOC -428- 200413407 165 170 175

Glu Ser His Lys Ser Pro Asn Met Ala Asn Cys Ser He Met lie Asp 180 185 190

Glu lie lie His His Leu Lys Arg Pro Pro Asn Pro Leu Leu Asp Pro 195 200 205

Asn Asn Leu Asn Ser Glu Asp Met Asp He Leu Met Glu Arg Asn Leu 210 215 220

Arg Thr Pro Asn Leu Leu Ala Phe Val Arg Ala Val Lys His Leu Glu 225 230 235 240

Asn Ala Ser Gly lie Glu Ala lie Leu Arg Asn Leu Gin Pro Cys Leu 245 250 255

Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro lie He lie Lys Ala 260 265 270

Gly Asp Trp Gin Glu Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr 275 280 285

Leu Glu Gin Ala Gin Glu Gin Gin 290 295

(2)序列編號NO: 682資料： (i) 序列特性： (A) 長度：301胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 682

Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 15 10 15

Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly 20 25 30

Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala 35 40 45

Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn He Ser 50 55 60

Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 100 105 110

Ser Gly Gly Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro He Ser 115 120 125

Ser Asp Phe Ala Val Lys He Arg Glu Leu Ser Asp Tyr Leu Leu Gin 130 135 140

Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Tyr Val Glu Gly Gly 145 150 155 160

Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie Ser Thr lie Asn Pro 165 170 175

Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Asn Cys 180 185 190

Ser lie Met He Asp Glu He lie His His Leu Lys Arg Pro Pro Asn O:\92\92747.DOC -429- 200413407 195 200 205

Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met Asp lie Leu 210 215 220

Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg Ala 225 230 235 240

Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie Leu Arg Asn 245 250 255

Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro 260 265 270 lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu Lys Leu Thr 275 280 285

Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 290 295 300 (2)序列編號NO·. 683資料： (i) 序列特性： (A) 長度：307胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 683

Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 15 10 15

Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly 20 25 30

Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala 35 40 45

Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser 50 55 60

Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 100 105 110

Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp Cys Ser Phe 115 120 125

Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu 130 135 140

Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 145 150 155 160

Gin Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 165 170 175 lie Ser Thr He Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 180 185 190

Pro Asn Met Ala Asn Cys Ser lie Met He Asp Glu He He His His 195 200 205

Leu Lys Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser 210 215 220

Glu Asp Met Asp He Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu -430

O:\92\92747.DOC 200413407 225 230 235 240

Leu Ala Phe Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie 245 250 255

Glu Ala He Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala 260 265 270

Ala Pro Ser Arg His Pro He lie lie Lys Ala Gly Asp Trp Gin Glu 275 280 285

Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin 290 295 300

Glu Gin Gin 305 (2)序列編號NO: 684資料： (i) 序列特性： (A) 長度：301胺基酸

(B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 684

Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 15 10 15

Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly 20 25 30

Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala 35 40 45

Phe Gin Pro Pro Pro Ser Cys Leu Arg Leu Val Gin Thr Asn lie Ser 50 55 60

Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 100 105 110

Ser Gly Gly Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser 115 120 125

Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin 130 135 140

Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Tyr Val Glu Gly Gly 145 150 155 160

Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He Ser Thr lie Asn Pro 165 170 175

Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Asn Cys 180 185 190

Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg Pro Pro Asn 195 200 205

Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met Asp He Leu 210 215 220

Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg Ala 225 230 235 240

Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie Leu Arg Asn O:\92\92747.DOC -431- 200413407 245 250 255

Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro 260 265 270 lie lie He Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu Lys Leu Thr 275 280 285

Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 290 295 300 (2)序列編號NO: 685資料： (i) 序列特性： (A) 長度：307胺基酸 (B) 形式：胺基酸 (C) 股數：單

(D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 685

Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 15 10 15

Arg Trp Met Gly Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly 20 25 30

Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala 35 40 45

Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser 50 55 60

Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp 65 70 75 80

He Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro 85 90 95

Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 100 105 110

Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp Cys Ser Phe 115 120 125

Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu 130 135 140

Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 145 150 155 160

Gin Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 165 170 175 lie Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 180 185 190

Pro Asn Met Ala Asn Cys Ser lie Met He Asp Glu lie He His His 195 200 205

Leu Lys Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser 210 215 220

Glu Asp Met Asp He Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu 225 230 235 240

Leu Ala Phe Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie 245 250 255

Glu Ala lie Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala 260 265 270

Ala Pro Ser Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu O:\92\92747.DOC -432- 275 280 285

Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin 290 295 300

Glu Gin Gin 305 (2)序列編號NO: 686資料： (i) 序列特性： (A)長度：302胺基酸 (B )形式·胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 686

Met Ala Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu 1 5 10 15

Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu 20 25 30

Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg 35 40 45

Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro 50 55 60

Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin 65 70 75 80

Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin 85 90 95

Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr 100 105 110

Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 115 120 125

Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala 130 135 140

Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Tyr Val Glu Gly 145 150 155 160

Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie Ser Thr lie Asn 165 170 175

Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Asn 180 185 190

Cys Ser He Met He Asp Glu lie He His His Leu Lys Arg Pro Pro 195 200 205

Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met Asp lie 210 215 220

Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg 225 230 235 240

Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie Leu Arg 245 250 255

Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His 260 265 270

Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu Lys Leu 275 280 285 433-

O:\92\92747.DOC 200413407

Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 290 295 300 (2)序列編號NO·· 687資料： (i) 序列特性： (A) 長度：301胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 687

Ala Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg 1 5 10 15

Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly 20 25 30

Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie His Phe 35 40 45

Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val 50 55 60

Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val 65 70 75 80

Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu 85 90 95

Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly 100 105 110

Gly Ser Gly Gly Gly Ser Gly Gly Gly Thr Gin Asp Cys Ser Phe Gin 115 120 125

His Ser Pro lie Ser Ser Asp Phe Ala Val Lys He Arg Glu Leu Ser 130 135 140

Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Tyr Val Glu Gly Gly 145 150 155 160

Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie Ser Thr lie Asn Pro 165 170 175

Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Asn Cys 180 185 190

Ser lie Met He Asp Glu lie lie His His Leu Lys Arg Pro Pro Asn 195 200 205

Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met Asp lie Leu 210 215 220

Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg Ala 225 230 235 240

Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie Leu Arg Asn 245 250 255

Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro 260 265 270 lie He He Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu Lys Leu Thr 275 280 285

Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 290 295 300 434-

O:\92\92747.DOC 200413407 (2)序列編號NO: 688資料： (i) 序列特性： (A) 長度：301胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 688

Ala Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr 1 5 10 15

Glu He His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys 20 25 30

Leu Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser 35 40 45

Glu Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser 50 55 60

Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly 65 70 75 80

Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Thr Gin Asp 85 90 95

Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie 100 105 110

Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala 115 120 125

Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val 130 135 140

Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Tyr Val Glu Gly Gly 145 150 155 160

Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie Ser Thr lie Asn Pro 165 170 175

Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Asn Cys 180 185 190

Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg Pro Pro Asn 195 200 205

Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met Asp lie Leu 210 215 220

Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg Ala 225 230 235 240

Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala He Leu Arg Asn 245 250 255

Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 290 295 300 (2)序列編號NO·· 689資料： O:\92\92747.DOC -435- 200413407 (i) 序列特性： (A) 長度：301胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D )拓撲結構·線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO.· 689

Ala Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu He His 15 10 15

Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe 20 25 30

Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu 35 40 45

Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys Leu 50 55 60

Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly 65 70 75 80

Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Thr Gin Asp Cys Ser Phe 85 90 95

Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu 100 105 110

Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 115 120 125

Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 130 135 140

Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Tyr Val Glu Gly Gly 145 150 155 160

Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie Ser Thr lie Asn Pro 165 170 175

Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Asn Cys 180 185 190

Ser lie Met He Asp Glu He lie His His Leu Lys Arg Pro Pro Asn 195 200 205

Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met Asp lie Leu 210 215 220

Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg Ala 225 230 235 240

Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie Leu Arg Asn 245 250 255

Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro 260 265 , 270 lie lie He Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu Lys Leu Thr 275 280 285

Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 290 295 300 (2)序列編號NO: 690資料： (i)序列特性： O:\92\92747.DOC -436- 200413407 (A) 長度：301胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 690

Ala Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser Arg Leu 1 5 10 15

Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp lie Thr 20 25 30

Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser 35 40 45

Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 50 55 60

Gly Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro He Ser Ser Asp 65 70 75 80

Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr 85 90 95

Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly 100 105 110

Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr 115 120 125

Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu 130 135 140 lie His Phe Val Thr Lys Cys Ala Phe Gin Pro Tyr Val Glu Gly Gly 145 150 155 160

Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie Ser Thr lie Asn Pro 165 170 175

Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Asn Cys 180 185 190

Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg Pro Pro Asn 195 200 205

Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met Asp lie Leu 210 215 220

Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg Ala 225 230 235 240

Val Lys His Leu Glu Asn Ala Ser Gly He Glu Ala He Leu Arg Asn 245 250 255

Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 290 295 300 (2)序列編號NO: 691資料： (i)序列特性： (A)長度：301胺基酸 O:\92\92747.DOC 437- 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 691

Ala Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val 15 10 15

Ala Leu Lys Pro Trp He Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu 20 25 30

Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly 35 40 45

Gly Ser Gly Gly Gly Ser Gly Gly Gly Thr Gin Asp Cys Ser Phe Gin 50 55 60

His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser 65 70 75 80

Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin 85 90 95

Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin Arg 100 105 110

Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly Leu 115 120 125

Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala Phe 130 135 140

Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Tyr Val Glu Gly Gly 145 150 155 160

Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie Ser Thr lie Asn Pro 165 170 175

Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Asn Cys 180 185 190

Ser He Met He Asp Glu lie lie His His Leu Lys Arg Pro Pro Asn 195 200 205

Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met Asp lie Leu 210 215 220

Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg Ala 225 230 235 240

Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie Leu Arg Asn 245 250 255

Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro 260 265 270 lie He lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu Lys Leu Thr 275 280 285

Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 290 295 300 (2)序列編號NO: 692資料： (i)序列特性： (A) 長度：301胺基酸 (B) 形式：胺基酸 O:\92\92747.DOC -438- 200413407 (c)股數：單 (D)拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 692

Ala Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser 15 10 15

Glu Gin Leu Val Ala Leu Lys Pro Trp He Thr Arg Gin Asn Phe Ser 20 25 30

Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly 35 40 45

Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Thr Gin Asp 50 55 60

Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie

65 70 75 80

Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala 85 90 95

Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val 100 105 110

Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys 115 120 125

Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr 130 135 140

Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Phe Tyr Val Glu Gly Gly 145 150 155 160

Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie Ser Thr lie Asn Pro 165 170 175

Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Asn Cys 180 185 190

Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg Pro Pro Asn 195 200 205

Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met Asp lie Leu 210 215 220

Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg Ala

225 230 235 240

Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie Leu Arg Asn 245 250 255

Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 290 295 300 (2)序列編號NO: 693資料： (i)序列特性： (A) 長度：307胺基酸 (B) 形式：胺基酸 (C) 股數：單 O:\92\92747.DOC -439- 200413407 (D)拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 693

Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu 15 10 15

Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser 20 25 30

Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu He His Phe Val 35 40 45

Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin 50 55 60

Thr Asn He Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala 65 70 75 80

Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu 85 90 95

Gin Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly 100 105 110

Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin 115 120 125

Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys 130 135 140 lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val 145 150 155 160

Ala Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 165 170 175

He Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 180 185 190

Pro Asn Met Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His 195 200 205

Leu Lys Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser 210 215 220

Glu Asp Met Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu 225 230 235 240

Leu Ala Phe Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly He

245 250 255

Glu Ala lie Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala 260 265 270

Ala Pro Ser Arg His Pro lie He lie Lys Ala Gly Asp Trp Gin Glu 275 280 285

Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin 290 295 300

Glu Gin Gin 305 (2)序列編號NO: 694資料： (i)序列特性： (A) 長度：307胺基酸 (B) 形式：胺基酸 (C) 股數：單 O:\92\92747.DOC -440- 200413407 (D)拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 694

Ala Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val 15 10 15

Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys 20 25 30

Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr 35 40 45

Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr 50 55 60

Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu 65 70 75 80

Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin

85 90 95

Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser 100 105 110

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp 115 120 125

Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie 130 135 140

Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala 145 150 155 160

Ser Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 165 170 175 lie Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 180 185 190

Pro Asn Met Ala Asn Cys Ser lie Met He Asp Glu He He His His 195 200 205

Leu Lys Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser 210 215 220

Glu Asp Met Asp He Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu 225 230 235 240

Leu Ala Phe Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie

245 250 255

Glu Ala He Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala 260 265 270

Ala Pro Ser Arg His Pro He lie lie Lys Ala Gly Asp Trp Gin Glu 275 280 285

Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin 290 295 300

Glu Gin Gin 305 (2)序列編號NO: 695資料： (i)序列特性： (A) 長度：307胺基酸 (B) 形式：胺基酸 (C) 股數：單 O:\92\92747.DOC -441- 200413407 (D)拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 695

Ala Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu 15 10 15

Ala Gin Arg Leu Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met 20 25 30

Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys 35 40 45

Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn 50 55 60 lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys 65 70 75 80

Pro Trp He Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys 85 90 95

Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly 100 105 110

Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp Cys 115 120 125

Ser Phe Gin His Ser Pro He Ser Ser Asp Phe Ala Val Lys lie Arg 130 135 140

Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser 145 150 155 160

Asn Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 165 170 175 lie Ser Thr He Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 180 185 190

Pro Asn Met Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His 195 200 205

Leu Lys Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser 210 215 220

Glu Asp Met Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu 225 230 235 240

Leu Ala Phe Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie

245 250 255

Glu Ala lie Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala 260 265 270

Ala Pro Ser Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu 275 280 285

Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin 290 295 300

Glu Gin Gin 305 (2)序列編號NO·· 696資料： (i)序列特性： (A) 長度：307胺基酸 (B) 形式：胺基酸 (C) 股數：單 O:\92\92747.DOC -442- (D)拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 696

Ala Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala 15 10 15

Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin 20 25 30

Gly Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys 35 40 45

Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie 50 55 60

Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro 65 70 75 80

Trp lie Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin 85 90 95

Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 100 105 110

Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp Cys Ser 115 120 125

Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu 130 135 140

Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn 145 150 155 160

Leu Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 165 170 175

He Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 180 185 190

Pro Asn Met Ala Asn Cys Ser He Met lie Asp Glu He He His His 195 200 205

Leu Lys Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser 210 215 220

Glu Asp Met Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu 225 230 235 240

Leu Ala Phe Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie 245 250 255

Glu Ala lie Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala 260 265 270

Ala Pro Ser Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu 275 280 285

Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin 290 295 300

Glu Gin Gin 305 (2)序列編號NO: 697資料： (i)序列特性： (A) 長度：307胺基酸 (B) 形式：胺基酸 (C) 股數：單 -443-

O:\92\92747.DOC 200413407 (D)拓撲結構：線形 (Π)分子類型：無 (xi)序列描述：序列編號NO: 697

Ala Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin Arg 15 10 15

Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly Leu 20 25 30

Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala Phe 35 40 45

Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser Arg 50 55 60

Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp lie 65 70 75 80

Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp 85 90 95

Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 100 105 110

Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp Cys Ser Phe Gin 115 120 125

His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser 130 135 140

Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin 145 150 155 160

Asp Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 165 170 175 lie Ser Thr He Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 180 185 190

Pro Asn Met Ala Asn Cys Ser lie Met lie Asp Glu lie He His His 195 200 205

Leu Lys Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser 210 215 220

Glu Asp Met Asp He Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu 225 230 235 240

Leu Ala Phe Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie

245 250 255

Glu Ala lie Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala 260 265 270

Ala Pro Ser Arg His Pro lie He lie Lys Ala Gly Asp Trp Gin Glu 275 280 285

Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin 290 295 300

Glu Gin Gin 305 (2)序列編號NO: 698資料： (i)序列特性： (A) 長度：307胺基酸 (B) 形式：胺基酸 (C) 股數：單 O:\92\92747.DOC -444- 200413407 (D)拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 698

Ala Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met 15 10 15

Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu 20 25 30

Arg Val Asn Thr Glu He His Phe Val Thr Lys Cys Ala Phe Gin Pro 35 40 45

Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu 50 55 60

Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp He Thr Arg

65 70 75 80

Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser 85 90 95

Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 100 105 110

Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp Cys Ser Phe Gin His Ser 115 120 125

Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr 130 135 140

Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu 145 150 155 160

Glu Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 165 170 175

He Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 180 185 190

Pro Asn Met Ala Asn Cys Ser He Met lie Asp Glu lie lie His His 195 200 205

Leu Lys Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser 210 215 220

Glu Asp Met Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu

225 230 235 240

Leu Ala Phe Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie 245 250 255

Glu Ala He Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala 260 265 270

Ala Pro Ser Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu 275 280 285

Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin 290 295 300

Glu Gin Gin 305 (2)序列編號NO: 699資料： (i)序列特性： (A) 長度：307胺基酸 (B) 形式：胺基酸 O:\92\92747.DOC 445- 200413407 (c)股數：單 (D)拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 699

Ala Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met 15 10 15

Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu 20 25 30

Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala Phe Gin Pro 35 40 45

Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu 50 55 60

Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg

65 70 75 80

Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser 85 90 95

Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 100 105 110

Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp Cys Ser Phe Gin His Ser 115 120 125

Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr 130 135 140

Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Asp .Glu 145 150 155 160

Glu Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 165 170 175

He Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 180 185 190

Pro Asn Met Ala Asn Cys Ser He Met lie Asp Glu He lie His His 195 200 205

Leu Lys Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser 210 215 220

Glu Asp Met Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu

225 230 235 240

Leu Ala Phe Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie 245 250 255

Glu Ala lie Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala 260 265 270

Ala Pro Ser Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu 275 280 285

Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin 290 295 300

Glu Gin Gin 305 (2)序列編號NO: 700資料： (i)序列特性： (A) 長度：307胺基酸 (B) 形式：胺基酸 O:\92\92747.DOC 446- 200413407 (c)股數：單 (D)拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 700

Ala Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met 15 10 15

Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu 20 25 30

Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala Phe Gin Pro 35 40 45

Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu 50 55 60

Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp He Thr Arg

65 70 75 80

Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Arg Pro Asp Ser Ser 85 90 95

Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 100 105 110

Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp Cys Ser Phe Gin His Ser 115 120 125

Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser Asp. Tyr 130 135 140

Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu 145 150 155 160

Glu Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 165 170 175

He Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 180 185 190

Pro Asn Met Ala Asn Cys Ser He Met lie Asp Glu lie lie His His 195 200 205

Leu Lys Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser 210 215 220

Glu Asp Met Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu

225 230 235 240

Leu Ala Phe Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie 245 250 255

Glu Ala lie Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala 260 265 270

Ala Pro Ser Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu 275 280 285

Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin 290 295 300

Glu Gin Gin 305 (2)序列編號NO: 701資料： (i)序列特性： (A) 長度：301胺基酸 (B) 形式：胺基酸 O:\92\92747.DOC -447- 200413407 (c)股數：單 (D)拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO.· 701

Ala Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie His 15 10 15

Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe 20 25 30

Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu 35 40 45

Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys Leu 50 55 60

Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly

65 70 75 80

Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Thr Gin Asp Cys Ser Phe 85 90 95

Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys He Arg Glu Leu 100 105 110

Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 115 120 125

Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 130 135 140

Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Tyr Val Glu Gly Gly 145 150 155 160

Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He Ser Thr lie Asn Pro 165 170 175

Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Asn Cys 180 185 190

Ser lie Met He Asp Glu He lie His His Leu Lys Arg Pro Pro Asn 195 200 205

Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met Asp lie Leu 210 215 220

Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg Ala

225 230 235 240

Val Lys His Leu Glu Asn Ala Ser Gly He Glu Ala lie Leu Arg Asn 245 250 255

Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 290 295 300 (2)序列編號NO: 702資料： (i)序列特性： (A) 長度：315胺基酸 (B) 形式：胺基酸 (C) 股數：單 O:\92\92747.DOC 448- 200413407 (D)拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 702

Ala Gin Asp Asp Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala 15 10 15

Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin 20 25 30

Gly Leu Leu Glu Arg Val Asn Thr Glu He His Phe Val Thr Lys Cys 35 40 45

Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie 50 55 60

Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro 65 70 75 80

Trp lie Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin 85 90 95

Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 100 105 110

Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 115 120 125

Gly Ser Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro He Ser Ser 130 135 140

Asp Phe Ala Val Lys He Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp 145 150 155 160

Tyr Pro Val Thr Val Ala Ser Asn Leu Tyr Val Glu Gly Gly Gly Gly 165 170 175

Ser Pro Gly Glu Pro Ser Gly Pro lie Ser Thr He Asn Pro Ser Pro 180 185 190

Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Asn Cys Ser lie 195 200 205

Met He Asp Glu lie lie His His Leu Lys Arg Pro Pro Asn Pro Leu 210 215 220

Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met Asp lie Leu Met Glu 225 230 235 240

Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg Ala Val Lys

245 250 255

His Leu Glu Asn Ala Ser Gly He Glu Ala lie Leu Arg Asn Leu Gin 260 265 270

Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg His Pro He lie 275 280 285 lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu Lys Leu Thr Phe Tyr 290 295 300

Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 305 310 315 (2)序列編號NO: 703資料： (i)序列特性： (A) 長度：301胺基酸 (B) 形式：胺基酸 (C) 股數：單 O:\92\92747.DOC 449- 200413407 (D)拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 703

Ala Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala 15 10 15

Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin 20 25 30

Gly Leu Leu Glu Arg Val Asn Thr Glu He His Phe Val Thr Lys Cys 35 40 45

Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie 50 55 60

Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro 65 70 75 80

Trp lie Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin

85 90 95

Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Gly 100 105 110

Ala Thr Ala Pro Thr Thr Gin Asp Cys Ser Phe Gin His Ser Pro He 115 120 125

Ser Ser Asp Phe Ala Val Lys He Arg Glu Leu Ser Asp Tyr Leu Leu 130 135 140

Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Tyr Val Glu Gly Gly 145 150 155 160

Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He Ser Thr lie Asn Pro 165 170 175

Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Asn Cys 180 185 190

Ser lie Met He Asp Glu lie He His His Leu Lys Arg Pro Pro Asn 195 200 205

Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met Asp lie Leu 210 215 220

Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg Ala 225 230 235 240

Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie Leu Arg Asn

245 250 255

Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 290 295 300 (2)序列編號NO·. 704資料： (i)序列特性： (A) 長度：307胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 O:\92\92747.DOC 450- 200413407 (ii)分子類型：無 (xi)序列描述：序列編號NO: 704

Ala Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala 15 10 15

Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin 20 25 30

Gly Leu Leu Glu Arg Val Asn Thr Glu He His Phe Val Thr Lys Cys 35 40 45

Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie 50 55 60

Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro 65 70 75 80

Trp He Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin 85 90 95

Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Gly 100 105 110

Ala Thr Ala Pro Thr Ala Gly Gin Pro Pro Leu Thr Gin Asp Cys Ser 115 120 125

Phe Gin His Ser Pro He Ser Ser Asp Phe Ala Val Lys lie Arg Glu 130 135 140

Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn 145 150 155 160

Leu Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 165 170 175

He Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 180 185 190

Pro Asn Met Ala Asn Cys Ser lie Met lie Asp Glu lie He His His 195 200 205

Leu Lys Arg Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser 210 215 220

Glu Asp Met Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu 225 230 235 240

Leu Ala Phe Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie 245 250 255

Glu Ala lie Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala 260 265 270

Ala Pro Ser Arg His Pro lie lie He Lys Ala Gly Asp Trp Gin Glu 275 280 285

Phe Arg Glu Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin 290 295 300

Glu Gin Gin 305 (2)序列編號NO: 705資料： (i)序列特性： (A) 長度：370胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 O:\92\92747.DOC .451- 200413407 (ii)分子類型：無 (xi)序列描述：序列編號NO: 705

Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser Phe Leu Leu 1 5 10 15

Lys Ser Leu Glu Gin Val Arg Lys He Gin Gly Asp Gly Ala Ala Leu 20 25 30

Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 35 40 45

Val Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser 50 55 60

Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His 65 70 75 80

Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie 85 90 95

Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala 100 105 110

Asp Phe Ala Thr Thr He Trp Gin Gin Met Glu Glu Leu Gly Met Ala 115 120 125

Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala 130 135 140

Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser 145 150 155 160

Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro Tyr 165 170 175

Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie Ser 180 185 190

Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn 195 200 205

Met Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala 210 215 220

Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin 225 230 235 240

Gly Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys 245 250 255

Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie 260 265 270

Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro 275 280 285

Trp lie Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin 290 295 300

Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 305 310 315 320

Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp Cys Ser 325 330 335

Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu 340 345 350

Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn 355 360 365

Leu Gin 370 (2)序列編號NO: 706資料： (i)序列特性： (A)長度：370胺基酸 O:\92\92747.DOC -452- 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 706

Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser Phe Leu Leu 15 10 15

Lys Ser Leu Glu Gin Val Arg Lys lie Gin Gly Asp Gly Ala Ala Leu 20 25 30

Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 35 40 45

Val Leu Leu Gly His Ser Leu Gly He Pro Trp Ala Pro Leu Ser Ser 50 55 60

Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His 65 70 75 80

Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly He 85 90 95

Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala 100 105 110

Asp Phe Ala Thr Thr lie Trp Gin Gin Met Glu Glu Leu Gly Met Ala 115 120 125

Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala 130 135 140

Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser 145 150 155 160

Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro Tyr 165 170 175

Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie Ser 180 185 190

Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn 195 200 205

Met Ala Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu 210 215 220

Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser 225 230 235 240

Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val 245 250 255

Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin 260 265 270 lie Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala 275 280 285

Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu 290 295 300

Gin Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly 305 310 315 320

Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin 325 330 335

Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys 340 345 350 lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val 355 360 365

Ala Ser 370 O:\92\92747.DOC -453- 200413407 (2)序列編號NO: 707資料： (i) 序列特性： (A) 長度：370胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 707

Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser Phe Leu Leu 1 5 10 15

Lys Ser Leu Glu Gin Val Arg Lys 20

Gin Glu Lys Leu Cys Ala Thr Tyr 35 40

Val Leu Leu Gly His Ser Leu Gly 50 55

Cys Pro Ser Gin Ala Leu Gin Leu 65 70

Ser Gly Leu Phe Leu Tyr Gin Gly 85

Ser Pro Glu Leu Gly Pro Thr Leu 100

Asp Phe Ala Thr Thr lie Trp Gin 115 120

Pro Ala Leu Gin Pro Thr Gin Gly 130 135

Phe Gin Arg Arg Ala Gly Gly Val 145 150

Phe Leu Glu Val Ser Tyr Arg Val 165

Val Glu Gly Gly Gly Gly Ser Pro 180

Thr lie Asn Pro Ser Pro Pro Ser 195 200

Met Ala Pro Pro Ser Cys Leu Arg 210 215

Leu Leu Gin Glu Thr Ser Glu Gin 225 230

Thr Arg Gin Asn Phe Ser Arg Cys 245

Ser Ser Thr Leu Gly Gly Gly Ser 260

Gly Gly Gly Ser Gly Gly Gly Ser 275 280

His Ser Pro He Ser Ser Asp Phe 290 295

Asp Tyr Leu Leu Gin Asp Tyr Pro 305 310

Asp Glu Glu Leu Cys Gly Gly Leu 325

Trp Met Glu Arg Leu Lys Thr Val

He Gin Gly Asp Gly Ala Ala Leu 25 30 Lys Leu Cys His Pro Glu Glu Leu 45 He Pro Trp Ala Pro Leu Ser Ser 60 Ala Gly Cys Leu Ser Gin Leu His 75 80 Leu Leu Gin Ala Leu Glu Gly He 90 95 Asp Thr Leu Gin Leu Asp Val Ala 105 110 Gin Met Glu Glu Leu Gly Met Ala 125 Ala Met Pro Ala Phe Ala Ser Ala 140 Leu Val Ala Ser His Leu Gin Ser 155 160 Leu Arg His Leu Ala Gin Pro Tyr 170 175 Gly Glu Pro Ser Gly Pro lie Ser 185 190 Lys Glu Ser His Lys Ser Pro Asn 205 Phe Val Gin Thr Asn lie Ser Arg 220 Leu Val Ala Leu Lys Pro Trp lie 235 240 Leu Glu Leu Gin Cys Gin Pro Asp 250 255 Gly Gly Gly Ser Gly Gly Gly Ser 265 270 Gly Thr Gin Asp Cys Ser Phe Gin 285 Ala Val Lys lie Arg Glu Leu Ser 300 Val Thr Val Ala Ser Asn Leu Gin 315 320 Trp Arg Leu Val Leu Ala Gin Arg 330 335 Ala Gly Ser Lys Met Gin Gly Leu

O:\92\92747.DOC -454- 200413407 340 345 350

Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala Phe 355 360 365

Gin Pro 370 (2)序列編號NO·. 708資料： (i) 序列特性： (A) 長度：370胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形

(ii) 分子類型：無 (xi)序列描述：序列編號NO: 708

Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser Phe Leu Leu 15 10 15

Lys Ser Leu Glu Gin Val Arg Lys lie Gin Gly Asp Gly Ala Ala Leu 20 25 30

Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 35 40 45

Val Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser 50 55 60

Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His 65 70 75 80

Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie 85 90 95

Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala 100 105 110

Asp Phe Ala Thr Thr He Trp Gin Gin Met Glu Glu Leu Gly Met Ala 115 120 125

Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala 130 135 140

Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser 145 150 155 160

Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro Tyr 165 170 175

Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie Ser 180 185 190

Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn 195 200 205

Met Ala Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val 210 215 220

Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys 225 230 235 240

Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr 245 250 255

Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr 260 265 270

Asn He Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu 275 280 285

Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin O:\92\92747.DOC 455- 200413407 290 295 300

Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser 305 310 315 320

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp 325 330 335

Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie 340 345 350

Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala 355 360 365

Ser Asn 370 (2)序列編號NO: 709資料： (i) 序列特性： (A) 長度：370胺基酸

(B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO_. 709

Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser Phe Leu Leu 15 10 15

Lys Ser Leu Glu Gin Val Arg Lys lie Gin Gly Asp Gly Ala Ala Leu 20 25 30

Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 35 40 45

Val Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser 50 55 60

Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His 65 70 75 80

Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie 85 90 95

Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala 100 105 110

Asp Phe Ala Thr Thr lie Trp Gin Gin Met Glu Glu Leu Gly Met Ala 115 120 125

Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala 130 135 140

Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser 145 150 155 160

Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro Tyr 165 170 175

Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie Ser 180 185 190

Thr He Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn 195 200 205

Met Ala Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu 210 215 220

Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met 225 230 235 240

Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys O:\92\92747.DOC -456- 200413407 245 250 255

Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn 260 265 270 lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys 275 280 285

Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys 290 295 300

Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly 305 310 315 320

Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp Cys 325 330 335

Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg 340 345 350

Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser 355 360 365

Asn Leu 370

(2)序列編號NO: 710資料： (i) 序列特性： (A) 長度：370胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 710

Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser Phe Leu Leu 15 10 15

Lys Ser Leu Glu Gin Val Arg Lys lie Gin Gly Asp Gly Ala Ala Leu 20 25 30

Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 35 40 45

Val Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser 50 55 60

Cys Pro Se.r Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His 65 70 75 80

Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie 85 90 95

Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala 100 105 110

Asp Phe Ala Thr Thr lie Trp Gin Gin Met Glu Glu Leu Gly Met Ala 115 120 125

Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala 130 135 140

Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser 145 150 155 160

Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro Tyr 165 170 175

Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie Ser 180 185 190

Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn O:\92\92747.DOC -457- 200413407 195 200 205

Met Ala Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 210 215 220

Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly 225 230 235 240

Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala 245 250 255

Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser 260 265 270

Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp 275 280 285 lie Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro 290 295 300

Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 305 310 315 320

Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp Cys Ser Phe 325 330 335

Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu 340 345 350

Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 355 360 365

Gin Asp 370 (2)序列編號NO: 711資料： (i) 序列特性： (A) 長度：370胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形

(ii) 分子類型：無 (xi)序列描述：序列編號NO: 711

Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser Phe Leu Leu 15 10 15

Lys Ser Leu Glu Gin Val Arg Lys lie Gin Gly Asp Gly Ala Ala Leu 20 25 30

Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 35 40 45

Val Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser 50 55 60

Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His 65 70 75 80

Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie 85 90 95

Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala 100 105 110

Asp Phe Ala Thr Thr lie Trp Gin Gin Met Glu Glu Leu Gly Met Ala 115 120 125

Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala 130 135 140

Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser O:\92\92747.DOC -458- 200413407 145 150 155 160

Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro Tyr 165 170 175

Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie Ser 180 185 190

Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn 195 200 205

Met Ala Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin Arg 210 215 220

Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly Leu 225 230 235 240

Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala Phe 245 250 255

Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser Arg 260 265 270

Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp lie 275 280 285

Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp 290 295 300

Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 305 310 315 320

Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp Cys Ser Phe Gin 325 330 335

His Ser Pro He Ser Ser Asp Phe Ala Val Lys He Arg Glu Leu Ser 340 345 350

Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin 355 360 365

Asp Glu 370 (2)序列編號NO: 712資料： (i) 序列特性： (A) 長度：370胺基酸 (B) 形式：胺基酸

(C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 712

Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser Phe Leu Leu 15 10 15

Lys Ser Leu Glu Gin Val Arg Lys He Gin Gly Asp Gly Ala Ala Leu 20 25 30

Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 35 40 45

Val Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser 50 55 60

Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His 65 70 75 80

Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie 85 90 95

Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala O:\92\92747.DOC 459 200413407 100 105 no

Asp Phe Ala Thr Thr lie Trp Gin Gin Met Glu Glu Leu Gly Met Ala 115 120 125

Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala 130 135 140

Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser 145 150 155 160

Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro Tyr 165 170 175

Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He Ser 180 185 190

Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn 195 200 205

Met Ala Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin Arg Trp 210 215 220

Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly Leu Leu 225 230 235 240

Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala Phe Gin 245 250 255

Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser Arg Leu 260 265 270

Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp He Thr 275 280 285

Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser 290 295 300

Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 305 310 315 320

Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp Cys Ser Phe Gin His 325 330 335

Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser Asp 340 345 350

Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Asp 355 360 365

Glu Glu 370 (2)序列編號NO: 713資料： (i) 序列特性： (A) 長度：364胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 713

Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser Phe Leu Leu 1 5 10 15

Lys Ser Leu Glu Gin Val Arg Lys lie Gin Gly Asp Gly Ala Ala Leu 20 25 30

Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 35 40 45

Val Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser -460-

O:\92\92747.DOC 200413407 50 55 60

Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His 65 70 75 80

Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie 85 90 95

Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala 100 105 110

Asp Phe Ala Thr Thr lie Trp Gin Gin Met Glu Glu Leu Gly Met Ala 115 120 125

Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala 130 135 140

Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser 145 150 155 160

Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro Tyr 165 170 175

Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He Ser 180 185 190

Thr He Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn 195 200 205

Met Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala 210 215 220

Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin 225 230 235 240

Gly Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys 245 250 255

Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie 260 265 270

Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro 275 280 285

Trp He Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin 290 295 300

Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Gly 305 310 315 320

Ala Thr Ala Pro Thr Thr Gin Asp Cys Ser Phe Gin His Ser Pro He 325 330 335

Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu 340 345 350

Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin

355 360 (2)序列編號NO: 714資料： (i) 序列特性： (A) 長度：378胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 714

Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser Phe Leu Leu 15 10 15

Lys Ser Leu Glu Gin Val Arg Lys He Gin Gly Asp Gly Ala Ala Leu O:\92\92747.DOC -461- 200413407 20 25 30

Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 35 40 45

Val Leu Leu Gly His Ser Leu Gly He Pro Trp Ala Pro Leu Ser Ser 50 55 60

Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His 65 70 75 80

Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie 85 90 95

Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala 100 105 110

Asp Phe Ala Thr Thr lie Trp Gin Gin Met Glu Glu Leu Gly Met Ala 115 120 125

Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala 130 135 140

Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser 145 150 155 160

Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro Tyr 165 170 175

Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He Ser 180 185 190

Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn 195 200 205

Met Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala 210 215 220

Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin 225 230 235 240

Gly Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys 245 250 255

Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie 260 265 270

Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro 275 280 285

Trp He Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin 290 295 300

Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 305 310 315 320

Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 325 330 335

Gly Ser Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser 340 345 350

Asp Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp 355 360 365

Tyr Pro Val Thr Val Ala Ser Asn Leu Gin 370 375 (2)序列編號NO: 715資料： (i) 序列特性： (A) 長度：370胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 O:\92\92747.DOC -462- 200413407 (xi)序列描述：序列編號NO: 715

Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser Phe Leu Leu 15 10 15

Lys Ser Leu Glu Gin Val Arg Lys lie Gin Gly Asp Gly Ala Ala Leu 20 25 30

Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 35 40 45

Val Leu Leu Gly His Ser Leu Gly He Pro Trp Ala Pro Leu Ser Ser 50 55 60

Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His 65 70 75 80

Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie 85 90 95

Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala 100 105 110

Asp Phe Ala Thr Thr lie Trp Gin Gin Met Glu Glu Leu Gly Met Ala 115 120 125

Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala 130 135 140

Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser 145 150 155 160

Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro Tyr 165 170 175

Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie Ser 180 185 190

Thr He Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn 195 200 205

Met Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala 210 215 220

Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin 225 230 235 240

Gly Leu Leu Glu Arg Val Asn Thr Glu He His Phe Val Thr Lys Cys 245 250 255

Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie 260 265 270

Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro 275 280 285

Trp lie Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin 290 295 300

Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Gly 305 310 315 320

Ala Thr Ala Pro Thr Ala Gly Gin Pro Pro Leu Thr Gin Asp Cys Ser 325 330 335

Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu 340 345 350

Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn 355 360 365

Leu Gin 370 (2)序列編號NO: 716資料： (i)序列特性： (A) 長度：155胺基酸 (B) 形式：胺基酸 O:\92\92747.DOC -463- 200413407 (c)股數：單 (D)拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 716

Ala Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu 15 10 15

Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg 20 25 30

Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val 35 40 45

Asn Thr Glu He His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro 50 55 60

Ser Cys Leu Arg Phe Val Gin Thr Asn He Ser Arg Leu Leu Gin Glu

65 70 75 80

Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn 85 90 95

Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu 100 105 110 '

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Thr 115 120 125

Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala Val 130 135 140

Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin 145 150 155 (2)序列編號NO: 717資料： (i) 序列特性： (A) 長度：155胺基酸

(B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 717

Ala Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg 15 10 15

Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly 20 25 30

Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu He His Phe 35 40 45

Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val 50 55 60

Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val 65 70 75 80

Ala Leu Lys Pro Trp He Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu 85 90 95 O:\92\92747.DOC -464- 200413407

Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly 100 105 110

Gly Ser Gly Gly Gly Ser Gly Gly Gly Thr Gin Asp Cys Ser Phe Gin 115 120 125

His Ser Pro lie Ser Ser Asp Phe Ala Val Lys He Arg Glu Leu Ser 130 135 140

Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val 145 150 155 (2)序列編號NO: 718資料： (i) 序列特性： (A) 長度：155胺基酸 (B) 形式：胺基酸

(C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO.· 718

Ala Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr 1 5 10 15

Glu He His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys 20 25 30

Leu Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser 35 40 45

Glu Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser 50 55 60

Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly 65 70 75 80

Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Thr Gin Asp 85 90 95

Cys Ser Phe Gin His Ser Pro He Ser Ser Asp Phe Ala Val Lys lie 100 105 110

Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala 115 120 125

Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val 130 135 140

Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr 145 150 155 (2)序列編號NO: 719資料： (i)序列特性： (A) 長度：155胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 O:\92\92747.DOC 465 200413407 (ii)分子類型：無 (xi)序列描述：序列編號NO: 719

Ala Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu He His 1 5 10 15

Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe 20 25 30

Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu 35 40 45

Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys Leu 50 55 60

Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly 65 70 75 80

Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Thr Gin Asp Cys Ser Phe 85 90 95

Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu 100 105 110

Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 115 120 125

Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 130 135 140

Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly 145 150 155 (2)序列編號NO: 720資料： (i) 序列特性： (A) 長度：155胺基酸 (B) 形式：胺基酸 (C) 股數：單

(D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO·· 720

Ala Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn He Ser Arg Leu 1 5 10 15

Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp He Thr 20 25 30

Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser 35 40 45

Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 50 55 60

Gly Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp 65 70 75 80

Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr 85 90 95

Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly 100 105 110

Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr 115 120 125 O:\92\92747.DOC -466- 200413407

Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu 130 135 140 lie His Phe Val Thr Lys Cys Ala Phe Gin Pro 145 150 155 (2)序列編號NO: 721資料： (i) 序列特性： (A) 長度：155胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形

(ii) 分子類型：無 (xi)序列描述：序列編號NO: 721

Ala Arg Phe Val Gin Thr Asn He Ser Arg Leu Leu Gin Glu Thr Ser 15 10 15

Glu Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser 20 25 30

Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly 35 40 45

Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Thr Gin Asp 50 55 60

Cys Ser Phe Gin His Ser Pro He Ser Ser Asp Phe Ala Val Lys lie 65 70 75 80

Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala 85 90 95

Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val 100 105 110

Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys 115 120 125

Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr 130 135 140

Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu 145 150 155 (2)序列編號NO: 722資料： (i) 序列特性： (A) 長度：155胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 O:\92\92747.DOC -467- 200413407 (xi)序列描述：序列編號NO: 722

Ala Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val 15 10 15

Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu 20 25 30

Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly 35 40 45

Gly Ser Gly Gly Gly Ser Gly Gly Gly Thr Gin Asp Cys Ser Phe Gin 50 55 60

His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser 65 70 75 80

Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin 85 90 95

Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin Arg 100 105 110

Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly Leu 115 120 125

Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala Phe 130 135 140

Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin 145 150 155 (2)序列編號NO: 723資料： (i) 序列特性： (A) 長度：370胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形

(ii) 分子類型：無 (xi)序列描述：序列編號NO: 723

Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 15 10 15

Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly 20 25 30

Leu Leu Glu Arg Val Asn Thr Glu He His Phe Val Thr Lys Cys Ala 35 40 45

Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser 50 55 60

Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 100 105 110

Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp Cys Ser Phe 115 120 125

Gin His Ser Pro He Ser Ser Asp Phe Ala Val Lys He Arg Glu Leu 130 135 140 O:\92\92747.DOC -468- 200413407

Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 145 150 155 160

Pro Asn Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser 195 200 205

Phe Leu Leu Lys Ser Leu Glu Gin Val Arg Lys He Gin Gly Asp Gly 210 215 220

Ala Ala Leu Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro 225 230 235 240

Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala Pro 245 250 255

Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser 260 265 270

Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu 275 280 285

Glu Gly lie Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu 290 295 300

Asp Val Ala Asp Phe Ala Thr Thr lie Trp Gin Gin Met Glu Glu Leu 305 310 315 320

Gly Met Ala Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe 325 330 335

Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His 340 345 350

Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala 355 360 365

Gin Pro 370 (2)序列編號NO·· 724資料： (i) 序列特性： (A) 長度：370胺基酸

(B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 724

Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 15 10 15

Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly 20 25 30

Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala 35 40 45

Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser 50 55 60

Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp 65 70 75 80 lie Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro O:\92\92747.DOC 469- 200413407 85 90 95

Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 100 105 110

Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp Cys Ser Phe 115 120 125

Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu 130 135 140

Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 145 150 155 160

Pro Asn Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser 195 200 205

Phe Leu Leu Lys Cys Leu Glu Gin Val Arg Lys lie Gin Gly Asp Gly 210 215 220

Ala Ala Leu Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro 225 230 235 240

Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala Pro 245 250 255

Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser 260 265 270

Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu 275 280 285

Glu Gly lie Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu 290 295 300

Asp Val Ala Asp Phe Ala Thr Thr lie Trp Gin Gin Met Glu Glu Leu 305 310 315 320

Gly Met Ala Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe 325 330 335

Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His 340 345 350

Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala 355 360 365

Gin Pro 370

(2)序列編號NO: 725資料： (i) 序列特性： (A) 長度：354胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 725

Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 15 10 15

Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly 20 25 30

Leu Leu Glu Arg Val Asn Thr Glu He His Phe Val Thr Lys Cys Ala O:\92\92747.DOC -470- 200413407 35 40 45

Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser 50 55 60

Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Gly Ala 100 105 110

Thr Ala Pro Thr Ala Gly Gin Pro Pro Leu Thr Gin Asp Cys Ser Phe 115 120 125

Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu 130 135 140

Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 145 150 155 160

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Gly Gly Ser Gly Gly Gly 165 170 175

Ser Asn Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser 180 185 190

Phe Leu Leu Lys Ser Leu Glu Gin Val Arg Lys lie Gin Gly Asp Gly 195 200 205

Ala Ala Leu Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro 210 215 220

Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala Pro 225 230 235 240

Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser 245 250 255

Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu 260 265 270

Glu Gly lie Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu 275 280 285

Asp Val Ala Asp Phe Ala Thr Thr He Trp Gin Gin Met Glu Glu Leu 290 295 300

Gly Met Ala Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe 305 310 315 320

Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His 325 330 335

Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala 340 345 350

Gin Pro (2)序列編號NO: 726資料： (i) 序列特性： (A) 長度：363胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 726

Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 15 10 15 O:\92\92747.DOC 471- 200413407

Arg Trp Met Glu Arg Leu Lys Thr Val Ala G'ly Ser Lys Met Gin Gly 20 25 30

Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala 35 40 45

Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn He Ser 50 55 60

Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp 65 70 75 80

He Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro 85 90 95

Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 100 105 110

Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 115 120 125

Ser Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp 130 135 140

Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr 145 150 155 160

Pro Val Thr Val Ala Ser Asn Leu Gin Tyr Val Glu Gly Gly Gly Gly

165 170 175

Ser Pro Gly Gly Gly Ser Gly Gly Gly Ser Asn Met Ala Thr Pro Leu 180 185 190

Gly Pro Ala Ser Ser Leu Pro Gin Ser Phe Leu Leu Lys Ser Leu Glu 195 200 205

Gin Val Arg Lys He Gin Gly Asp Gly Ala Ala Leu Gin Glu Lys Leu 210 215 220

Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly 225 230 235 240

His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gin 245 250 255

Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser Gly Leu Phe 260 265 270

Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie Ser Pro Glu Leu 275 280 285

Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala Asp Phe Ala Thr 290 295 300

Thr lie Trp Gin Gin Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gin 305 310 315 320

Pro Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gin Arg Arg

325 330 335

Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser Phe Leu Glu Val 340 345 350

Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro 355 360 (2)序列編號NO: 727資料： (i) 序列特性： (A) 長度：348胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 O:\92\92747.DOC -472- 200413407 (xi)序列描述：序列編號NO: 727

Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 15 10 15

Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly 20 25 30

Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala 35 40 45

Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn He Ser 50 55 60

Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Gly Ala 100 105 110

Thr Ala Pro Thr Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser 115 120 125

Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin 130 135 140

Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Tyr Val Glu Gly Gly Gly 145 150 155 160

Gly Ser Pro Gly Gly Gly Ser Gly Gly Gly Ser Asn Met Ala Thr Pro 165 170 175

Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser Phe Leu Leu Lys Ser Leu 180 185 190

Glu Gin Val Arg Lys lie Gin Gly Asp Gly Ala Ala Leu Gin Glu Lys 195 200 205

Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu 210 215 220

Gly His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser 225 230 235 240

Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser Gly Leu 245 250 255

Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly He Ser Pro Glu 260 265 270

Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala Asp Phe Ala 275 280 285

Thr Thr He Trp Gin Gin Met Glu Glu Leu Gly Met Ala Pro Ala Leu 290 295 300

Gin Pro Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gin Arg 305 310 315 320

Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser Phe Leu Glu 325 330 335

Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro 340 345 (2)序列編號NO: 728資料： (i)序列特性： (A) 長度：359胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 O:\92\92747.DOC 473- 200413407 (ii)分子類型：無 (xi)序列描述：序列編號NO: 728

Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 15 10 15

Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly 20 25 30

Leu Leu Glu Arg Val Asn Thr Glu He His Phe Val Thr Lys Cys Ala 35 40 45

Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser 50 55 60

Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Arg Pro Trp 65 70 75 80

He Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro 85 90 95

Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Thr 100 105 110

Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala Val 115 120 125

Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr 130 135 140

Val Ala Ser Asn Leu Gin Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly 145 150 155 160

Glu Pro Ser Gly Pro lie Ser Thr lie Asn Pro Ser Pro Pro Ser Lys 165 170 175

Glu Ser His Lys Ser Pro Asn Met Ala Thr Pro Leu Gly Pro Ala Ser 180 185 190

Ser Leu Pro Gin Ser Phe Leu Leu Lys Cys Leu Glu Gin Val Arg Lys 195 200 205

He Gin Gly Asp Gly Ala Ala Leu Gin Glu Lys Leu Cys Ala Thr Tyr 210 215 220

Ala Gly Cys Leu Ser Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly 260 265 270

Leu Leu Gin Ala Leu Glu Gly lie Ser Pro Glu Leu Gly Pro Thr Leu 275 280 285

Asp Thr Leu Gin Leu Asp Val Ala Asp Phe Ala Thr Thr He Trp Gin 290 295 300

Gin Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gin Pro Thr Gin Gly 305 310 315 320

Ala Met Pro Ala Phe Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly Val 325 330 335

Leu Val Ala Ser His Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg Val 340 345 350

Leu Arg His Leu Ala Gin Pro 355 (2)序列編號NO: 729資料： (i)序列特性： (A)長度：364胺基酸 O:\92\92747.DOC -474- 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 729

Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 1 5 10 15

Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly 20 25 30

Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala 35 40 45

Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser

50 55 60

Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp 65 70 75 80

He Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro 85 90 95

Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 100 105 110

Ser Gly Gly Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser 115 120 125

Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin 130 135 140

Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Tyr Val Glu Gly Gly 145 150 155 160

Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He Ser Thr lie Asn Pro 165 170 175

Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Thr Pro 180 185 190

Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser Phe Leu Leu Lys Cys Leu 195 200 205

Glu Gin Val Arg Lys He Gin Gly Asp Gly Ala Ala Leu Gin Glu Lys

210 215 220

Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu 225 230 235 240

Gly His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser 245 250 255

Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser Gly Leu 260 265 270

Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie Ser Pro Glu 275 280 285

Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala Asp Phe Ala 290 295 300

Thr Thr lie Trp Gin Gin Met Glu Glu Leu Gly Met Ala Pro Ala Leu 305 310 315 320

Gin Pro Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gin Arg 325 330 335

Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser Phe Leu Glu 340 345 350

Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro 355 360 (2)序列編號NO·· 730資料： O:\92\92747.DOC -475- 200413407 (i) 序列特性： (A) 長度：370胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 730

Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 15 10 15

Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly 20 25 30

Leu Leu Glu Arg Val Asn Thr Glu He His Phe Val Thr Lys Cys Ala 35 40 45

Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn He Ser 50 55 60

Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly .100 105 110

Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp Cys Ser Phe 115 120 125

Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu 130 135 140

Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 145 150 155 160

Gin Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 165 170 175

He Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 180 185 190

Pro Asn Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser 195 200 205

Phe Leu Leu Lys Cys Leu Glu Gin Val Arg Lys lie Gin Gly Asp Gly 210 215 220

Ala Ala Leu Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro 225 230 235 240

Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala Pro 245 250 255

Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser 260 265 270

Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu 275 280 285

Glu Gly lie Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu 290 295 300

Asp Val Ala Asp Phe Ala Thr Thr He Trp Gin Gin Met Glu Glu Leu 305 310 315 320

Gly Met Ala Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe 325 330 335

Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His 340 345 350

Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg Val Val Arg His Leu Ala O:\92\92747.DOC -476- 200413407 355 360 365

Gin Pro 370 (2)序列編號NO: 731資料： (i) 序列特性： (A) 長度：364胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無

(xi)序列描述：序列編號NO: 731

Ala Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser Arg Leu 15 10 15

Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp lie Thr 20 25 30

Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser 35 40 45

Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 50 55 60

Gly Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro He Ser Ser Asp 65 70 75 80

Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr 85 90 95

Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly 100 105 110

Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr 115 120 125

Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu 130 135 140

He His Phe Val Thr Lys Cys Ala Phe Gin Pro Tyr Val Glu Gly Gly 145 150 155 160

Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie Ser Thr lie Asn Pro 165 170 175

Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Thr Pro 180 185 190

Leu Gly Pro Ala Ser Ser Val Pro Gin Ser Phe Leu Leu Lys Cys Leu 195 200 205

Glu Gin Val Arg Lys lie Gin Gly Asp Gly Ala Ala Leu Gin Glu Lys 210 215 220

Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu 225 230 235 240

Gly His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser 245 250 255

Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser Gly Leu 260 265 270

Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly He Ser Pro Glu 275 280 285

Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala Asp Phe Ala 290 295 300

Thr Thr He Trp Gin Gin Met Glu Glu Leu Gly Met Ala Pro Ala Leu O:\92\92747.DOC 477- 200413407 305 310 315 320

Gin Pro Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gin Arg 325 330 335

Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser Phe Leu Glu 340 345 350

Val Ser Tyr Arg Val He Arg His Leu Ala Gin Pro 355 360 (2)序列編號NO·· 732資料： (i) 序列特性· (A) 長度·· 370胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 732

Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu 15 10 15

Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser 20 25 30

Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu He His Phe Val 35 40 45

Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin 50 55 60

Thr Asn He Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala 65 70 75 80

Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu 85 90 95

Gin Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly 100 105 110

Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin 115 120 125

Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys 130 135 140

He Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val 145 150 155 160

Ala Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 165 170 175 lie Ser Thr lie Asn Pro Ser His Pro Ser Lys Glu Ser His Lys Ser 180 185 190

Pro Asn Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser 195 200 205

Phe Leu Leu Lys Cys Leu Glu Gin Val Arg Lys He Gin Gly Asp Gly 210 215 220

Ala Ala Leu Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro 225 230 235 240

Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly He Pro Trp Ala Pro 245 250 255

Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser 260 265 270 -478-

O:\92\92747.DOC 200413407

Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu 275 280 285

Glu Gly He Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu 290 295 300

Asp Val Ala Asp Phe Ala Thr Thr lie Trp Gin Gin Met Glu Glu Leu 305 310 315 320

Gly Met Ala Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe 325 330 335

Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His 340 345 350

Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala 355 360 365

Gin Pro 370 (2)序列編號NO: 733資料：

(i) 序列特性： (A) 長度：370胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO·. 733

Ala Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val 15 10 15

Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys 20 25 30

Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu He His Phe Val Thr 35 40 45

Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr 50 55 60

Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu 65 70 75 80

Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin 85 90 95

Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser 100 105 110

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp 115 120 125

Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie 130 135 140

Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala 145 150 155 160

Ser Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 165 170 175

He Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 180 185 190

Pro Asn Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser 195 200 205

Phe Leu Leu Lys Cys Leu Glu Gin Val Arg Lys lie Gin Gly Asp Gly 210 215 220 O:\92\92747.DOC -479- 200413407

Ala Ala Leu Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro 225 230 235 240

Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala Pro 245 250 255

Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser 260 265 270

Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu 275 280 285

Glu Gly lie Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu 290 295 300

Asp Val Ala Asp Phe Ala Thr Thr lie Trp Gin Gin Met Glu Glu Leu 305 310 315 320

Gly Met Ala Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe 325 330 335

Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His 340 345 350

Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg Val lie Arg His Leu Ala 355 360 365

Gin Pro 370 (2)序列編號NO: 734資料： (i) 序列特性： (A) 長度：370胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 734

Ala Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu 15 10 15

Ala Gin Arg Leu Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met 20 25 30

Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys 35 40 45

Pro Trp He Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys 85 90 95

Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly 100 105 110

Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp Cys 115 120 125

Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg 130 135 140

Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser 145 150 155 160

Asn Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 165 170 175 O:\92\92747.DOC -480 200413407 lie Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 180 185 190

Pro Asn Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser 195 200 205

Phe Leu Leu Lys Cys Leu Glu Gin Val Arg Lys He Gin Gly Asp Gly 210 215 220

Ala Ala Leu Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro 225 230 235 240

Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala Pro 245 250 255

Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser 260 265 270

Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu 275 280 285

Glu Gly lie Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu 290 295 300

Asp Val Ala Asp Phe Ala Thr Thr lie Trp Gin Gin Met Glu Glu Leu 305 310 315 320

Gly Met Ala Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe

325 330 335

Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His 340 345 350

Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala 355 360 365

Gin Pro 370 (2)序列編號NO: 735資料： (i) 序列特性： (A) 長度：370胺基酸 (B) 形式：胺基酸 (C) 股數：單

(D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 735

Ala Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met 15 10 15

Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu 20 25 30

Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala Phe Gin Pro 35 40 45

Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn He Ser Arg Leu Leu 50 55 60

Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg 65 70 75 80

Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser 85 90 95

Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 100 105 110

Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp Cys Ser Phe Gin His Ser 115 120 125 O:\92\92747.DOC -481- 200413407

Pro He Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr 130 135 140

Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu 145 150 155 160

Glu Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 165 170 175 lie Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 180 185 190

Pro Asn Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser 195 200 205

Phe Leu Leu Lys Cys Leu Glu Gin Val Arg Lys lie Gin Gly Asp Gly 210 215 220

Ala Ala Leu Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro 225 230 235 240

Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly He Pro Trp Ala Pro 245 250 255

Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser 260 265 270

Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu 275 280 285

Glu Gly lie Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu 290 295 300

Asp Val Ala Asp Phe Ala Thr Thr lie Trp Gin Gin Met Glu Glu Leu 305 310 315 320

Gly Met Ala Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe 325 330 335

Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His 340 345 350

Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala 355 360 365

Gin Pro 370 (2)序列編號NO: 736資料： (i) 序列特性：

(A)長度：364胺基酸 (B )形式·胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 736

Ala Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu He His 15 10 15

Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe 20 25 30

Val Gin Thr Asn He Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu 35 40 45

Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys Leu 50 55 60

Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly 65 70 75 80 O:\92\92747.DOC -482- 200413407

Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Thr Gin Asp Cys Ser Phe 85 90 95

Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys He Arg Glu Leu 100 105 110

Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 115 120 125

Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 130 135 140

Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Tyr Val Glu Gly Gly 145 150 155 160

Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie Ser Thr lie Asn Pro 165 170 175

Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Thr Pro 180 185 190

Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser Phe Leu Leu Lys Cys Leu 195 200 205

Glu Gin Val Arg Lys lie Gin Gly Asp Gly Ala Ala Leu Gin Glu Lys 210 215 220

Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu

225 230 235 240

Gly His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser 245 250 255

Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser Gly Leu 260 265 270

Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly He Ser Pro Glu 275 280 285

Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala Asp Phe Ala 290 295 300

Thr Thr lie Trp Gin Gin Met Glu Glu Leu Gly Met Ala Pro Ala Leu 305 310 315 320

Gin Pro Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gin Arg 325 330 335

Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser Phe Leu Glu 340 345 350

Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro 355 360

(2)序列編號NO·. 737資料： (i) 序列特性： (A) 長度：364胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 737

Ala Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu He His 15 10 15

Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe 20 25 30

Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu 35 40 45 O:\92\92747.DOC -483-

Val Ala Leu Lys Pro Trp He Thr Arg Gin Asn Phe Ser Arg Cys Leu 50 55 60

Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly 65 70 75 80

Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Thr Gin Asp Cys Ser Phe 85 90 95

Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu 100 105 110

Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 115 120 125

Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 130 135 140

Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Tyr Val Glu Gly Gly 145 150 155 160

Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie Ser Thr lie Asn Pro 165 170 175

Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Thr Pro 180 185 190

Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser Phe Leu Leu Lys Cys Leu 195 200 205

Glu Gin Val Arg Lys lie Gin Gly Asp Gly Ala Ala Leu Gin Glu Lys 210 215 220

Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu 225 230 235 240

Gly His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser 245 250 255

Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser Gly Leu 260 265 270

Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly He Ser Pro Glu 275 280 285

Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala Asp Phe Ala 290 295 300

Thr Thr lie Trp Gin Gin Met Glu Glu Leu Gly Met Ala Pro Ala Leu 305 310 315 320

Gin Pro Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gin Arg 325 330 335

Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser Phe Leu Glu 340 345 350

Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro 355 360 (2)序列編號NO: 738資料： (i) 序列特性： (A) 長度：370胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 738

Ala Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met 15 10 15 484-

O:\92\92747.DOC 200413407

Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu 20 25 30

Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala Phe Gin Pro 35 40 45

Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu 50 55 60

Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg 65 70 75 80

Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Arg Pro Asp Ser Ser 85 90 95

Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 100 105 110

Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp Cys Ser Phe Gin His Ser 115 120 125

Pro He Ser Ser Asn Phe Ala Val Lys He Arg Glu Leu Ser Asp Tyr 130 135 140

Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu 145 150 155 160

Glu Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro

165 170 175 lie Phe Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 180 185 190

Pro Asn Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser 195 200 205

Phe Leu Leu Lys Cys Leu Glu Gin Val Arg Lys lie Gin Gly Asp Gly 210 215 220

Ala Ala Leu Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro 225 230 235 240

Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala Pro 245 250 255

Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser 260 265 270

Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu 275 280 285

Glu Gly lie Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu 290 295 300

Asp Val Ala Asp Phe Ala Thr Thr He Trp Gin Gin Met Glu Glu Leu 305 310 315 320

Gly Met Ala Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe

325 330 335

Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His 340 345 350

Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala 355 360 365

Gin Pro 370 (2)序列編號NO: 739資料： ⑴序列特性： (A) 長度：370胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 O:\92\92747.DOC -485- 200413407 (ii)分子類型：無 (xi)序列描述：序列編號NO: 739

Ala Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin Arg Trp 15 10 15

Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly Leu Leu 20 25 30

Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala Phe Gin 35 40 45

Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser Arg Leu 50 55 60

Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp lie Thr 65 70 75 80

Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser 85 90 95

Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 100 105 110

Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp Cys Ser Phe Gin His 115 120 125

Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser Asp 130 135 140

Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Asp 145 150 155 160

Pro Asn Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser 195 200 205

Phe Leu Leu Lys Cys Leu Glu Gin Val Arg Lys lie Gin Gly Asp Gly 210 215 220

Ala Ala Leu Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro 225 230 235 240

Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala Pro 245 250 255

Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser 260 265 270

Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu 275 280 285

Glu Gly lie Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu 290 295 300

Asp Val Ala Asp Phe Ala Thr Thr He Trp Gin Gin Met Glu Glu Leu 305 310 315 320

Gly Met Ala Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe 325 330 335

Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His 340 345 350

Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala 355 360 365

Gin Pro 370 (2)序列編號NO: 740資料： (i)序列特性： (A)長度：370胺基酸 O:\92\92747.DOC -486- 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 740

Ala Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin Arg 1 5 10 15

Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly Leu 20 25 30

Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala Phe 35 40 45

Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser Arg 50 55 60

Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp lie 65 70 75 80

Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp 85 90 95

Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 100 105 110

Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp Cys Ser Phe Gin 115 120 125

His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser 130 135 140

Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin 145 150 155 160

Asp Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 165 170 175 lie Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 180 185 190

Pro Asn Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser 195 200 205

Phe Leu Leu Lys Cys Leu Glu Gin Val Arg Lys lie Gin Gly Asp Gly 210 215 220

Ala Ala Leu Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro 225 230 235 240

Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly He Pro Trp Ala Pro 245 250 255

Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser 260 265 270

Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu 275 280 285

Glu Gly He Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu 290 295 300

Asp Val Ala Asp Phe Ala Thr Thr lie Trp Gin Gin Met Glu Glu Leu 305 310 315 320

Gly Met Ala Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe 325 330 335

Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His 340 345 350

Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala 355 360 365

Gin Pro 370 O:\92\92747.DOC -487- 200413407 (2)序列編號NO: 741資料： (i) 序列特性： (A) 長度：370胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 741

Ala Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala 15 10 15

Thr Val Ala Gly Ser Lys Met Gin 25 30 Glu He His Phe Val Thr Lys Cys 45 Leu Arg Phe Val Gin Thr Asn lie 60 Glu Gin Leu Val Ala Leu Lys Pro 75 80 Arg Cys Leu Glu Leu Gin Cys Gin 90 95 Gly Ser Gly Gly Gly Ser Gly Gly 105 110 Gly Ser Gly Thr Gin Asp Cys Ser 125 Asp Phe Ala Val Lys lie Arg Glu 140 Tyr Pro Val Thr Val Ala Ser Asn 155 160 Ser Pro Gly Glu Pro Ser Gly Pro 170 175 Pro Ser Lys Glu Ser His Lys Ser 185 190 Pro Ala Ser Ser Leu Pro Gin Ser 205 Val Arg Lys lie Gin Gly Asp Gly 220 Ala Thr Tyr Lys Leu Cys His Pro 235 240 Ser Leu Gly lie Pro Trp Ala Pro 250 255 Leu Gin Leu Ala Gly Cys Leu Ser 265 270 Tyr Gin Gly Leu Leu Gin Ala Leu 285 Pro Thr Leu Asp Thr Leu Gin Leu 300 He Trp Gin Gin Met Glu Glu Leu 315 320 Thr Gin Gly Ala Met Pro Ala Phe 330 335 Gly Gly Val Leu Val Ala Ser His

Gin Arg Trp Met Glu Arg Leu Lys 20

Gly Leu Leu Glu Arg Val Asn Thr 35 40

Ala Phe Gin Pro Pro Pro Ser Cys 50 55

Ser Arg Leu Leu Gin Glu Thr Ser 65 70

Trp lie Thr Arg Gin Asn Phe Ser 85

Pro Asp Ser Ser Thr Leu Gly Gly 100

Gly Ser Gly Gly Gly Ser Gly Gly 115 120

Phe Gin His Ser Pro lie Ser Ser 130 135

Leu Ser Asp Tyr Leu Leu Gin Asp 145 150

Leu Tyr Val Glu Gly Gly Gly Gly 165

He Ser Thr He Asn Pro Ser Pro 180

Pro Asn Met Ala Thr Pro Leu Gly 195 200

Phe Leu Leu Lys Cys Leu Glu Gin 210 215

Ala Ala Leu Gin Glu Lys Leu Cys 225 230

Glu Glu Leu Val Leu Leu Gly His 245

Leu Ser Ser Cys Pro Ser Gin Ala 260

Gin Leu His Ser Gly Leu Phe Leu 275 280

Glu Gly lie Ser Pro Glu Leu Gly 290 295

Asp Val Ala Asp Phe Ala Thr Thr 305 310

Gly Met Ala Pro Ala Leu Gin Pro 325

Ala Ser Ala Phe Gin Arg Arg Ala O:\92\92747.DOC 488- 200413407 340 345 350

Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala 355 360 365

Gin Pro 370 (2)序列編號NO: 742資料： (i) 序列特性： (A) 長度：364胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形

(ii) 分子類型：無 (xi)序列描述：序列編號NO: 742

Ala Thr Asn He Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val 1 5 10 15

Ala Leu Lys Pro Trp He Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu 20 25 30

Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly 35 40 45

Gly Ser Gly Gly Gly Ser Gly Gly Gly Thr Gin Asp Cys Ser Phe Gin 50 55 60

His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser 65 70 75 80

Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin 85 90 95

Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin Arg 100 105 110

Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly Leu 115 120 125

Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala Phe 130 135 140

Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Tyr Val Glu Gly Gly 145 150 155 160

Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie Ser Thr lie Asn Pro 165 170 175

Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Thr Pro 180 185 190

Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser Phe Leu Leu Lys Cys Leu 195 200 205

Glu Gin Val Arg Lys lie Gin Gly Asp Gly Ala Ala Leu Gin Glu Lys 210 215 220

Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu 225 230 235 240

Gly His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser 245 250 255

Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser Gly Leu 260 265 270

Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly He Ser Pro Glu 275 280 285 O:\92\92747.DOC -489

Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala Asp Phe Ala 290 295 300

Thr Thr lie Trp Gin Gin Met Glu Glu Leu Gly Met Ala Pro Ala Leu 305 310 315 320

Gin Pro Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gin Arg 325 330 335

Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser Phe Leu Glu 340 345 350

Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro 355 360 (2)序列編號NO: 743資料： (i) 序列特性： (A) 長度：355胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 743

Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 15 10 15

Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly 20 25 30

Leu Leu Glu Arg Val Asn Thr Glu He His Phe Val Thr Lys Cys Ala 35 40 45

Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser 50 55 60

Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 100 105 110

Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp Cys Ser Phe 115 120 125

Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu 130 135 140

Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 145 150 155 160

Gin Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Gly Gly Ser Gly Gly 165 170 175

Gly Ser Asn Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin 180 185 190

Ser Phe Leu Leu Lys Ser Leu Glu Gin Val Arg Lys lie Gin Gly Asp 195 200 205

Gly Ala Ala Leu Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His 210 215 220

Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala 225 230 235 240

Pro Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu 245 250 255 490-

O:\92\92747.DOC 200413407

Ser Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala 260 265 270

Leu Glu Gly lie Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin 275 280 285

Leu Asp Val Ala Asp Phe Ala Thr Thr lie Trp Gin Gin Met Glu Glu 290 295 300

Leu Gly Met Ala Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala 305 310 315 320

Phe Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser 325 330 335

His Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu 340 345 350

Ala Gin Pro 355 (2)序列編號NO: 744資料：

(i)序列特性： (A) 長度：370胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (Π)分子類型：無 (xi)序列描述：序列編號NO: 744

Ala Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala 15 10 15

Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin 20 25 30

Gly Leu Leu Glu Arg Val Asn Thr Glu He His Phe Val Thr Lys Cys 35 40 45

Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie 50 55 60

Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro 65 70 75 80

Trp lie Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin 85 90 95

Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 100 105 110

Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp Cys Ser 115 120 125

Phe Gin His Ser Pro He Ser Ser Asp Ser Ala Val Lys lie Arg Glu 130 135 140

Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn 145 150 155 160

Leu Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro 165 170 175 lie Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 180 185 190

Pro Asn Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser 195 200 205

Phe Leu Leu Lys Cys Leu Glu Gin Val Arg Lys He Gin Gly Asp Gly O:\92\92747.DOC -491- 200413407 210 215 220

Ala Ala Leu Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro 225 230 235 240

Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala Pro 245 250 255

Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser 260 265 270

Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu 275 280 285

Glu Gly lie Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu 290 295 300

Asp Val Ala Asp Phe Ala Thr Thr lie Trp Gin Gin Met Glu Glu Leu 305 310 315 320

Gly Met Ala Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe 325 330 335

Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His 340 345 350

Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala 355 360 365

Gin Pro 370 (2)序列編號NO: 745資料： (i) 序列特性： (A) 長度：366胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 745

Ala Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met 1 5 10 15

Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu 20 25 30

Arg Val Asn Thr Glu lie His Phe Val Thr Lys Tyr Ala Phe Gin Pro 35 40 45

Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu 50 55 60

Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg 65 70 75 80

Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Arg Pro Asp Ser Ser 85 90 95

Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 100 105 110

Gly Ser Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser 115 120 125

Asp Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp 130 135 140

Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Tyr Val Glu 145 150 155 160

Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He Ser Thr lie -492-

O:\92\92747.DOC 165 170 175

Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala 180 185 190

Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser Phe Leu Leu Lys 195 200 205

Cys Leu Glu Gin Val Arg Lys lie Gin Gly Asp Gly Ala Ala Leu Gin 210 215 220

Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val 225 230 235 240

Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys 245 250 255

Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser 260 265 270

Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie Ser 275 280 285

Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala Asp 290 295 300

Phe Ala Thr Thr He Trp Gin Gin Met Glu Glu Leu Gly Met Ala Pro 305 310 315 320

Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Phe 325 330 335

Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser Phe 340 345 350

Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro 355 360 365 (2)序列編號NO: 746資料： (i) 序列特性： (A) 長度：364胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 746

Ala Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu He His 15 10 15

Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe 20 25 30

Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu 35 40 45

Val Ala Leu Lys Pro Trp He Thr Arg Gin Asn Phe Phe Arg Cys Leu 50 55 60

Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly 65 70 75 80

Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Thr Gin Asp Cys Ser Phe 85 90 95

Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu 100 105 110

Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 115 120 125

Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin -493-

O:\92\92747.DOC 200413407 130 135 140

Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Tyr Val Glu Gly Gly 145 150 155 160

Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie Ser Thr lie Asn Pro 165 170 175

Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Thr Pro 180 185 190

Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser Phe Leu Leu Lys Cys Leu 195 200 205

Glu Gin Val Arg Lys He Gin Gly Asp Gly Ala Ala Leu Gin Glu Lys 210 215 220

Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu 225 230 235 240

Gly His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser 245 250 255

Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser Gly Leu 260 265 270

Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly He Ser Pro Glu 275 280 285

Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala Asp Phe Ala 290 295 300

Thr Thr lie Trp Gin Gin Met Glu Glu Leu Gly Met Ala Pro Ala Leu 305 310 315 320

Gin Pro Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gin Arg 325 330 335

Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser Phe Leu Glu 340 345 350

Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro 355 360 (2)序列編號NO: 747資料： (i) 序列特性： (A) 長度：378胺基酸 (B) 形式：胺基酸

(C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 747

Ala Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala 15 10 15

Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin 20 25 30

Gly Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys 35 40 45

Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie 50 55 60

Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro 65 70 75 80

Trp lie Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin 85 90 95

Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly O:\92\92747.DOC -494- 200413407 100 105 110

Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 115 120 125

Gly Ser Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser 130 135 140

Asp Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp 145 150 155 160

Tyr Pro Val Thr Val Ala Ser Asn Leu Tyr Val Glu Gly Gly Gly Gly 165 170 175

Ser Pro Gly Glu Pro Ser Gly Pro lie Ser Thr lie Asn Pro Ser Pro 180 185 190

Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Thr Pro Leu Gly 195 200 205

Pro Ala Ser Ser Leu Pro Gin Ser Phe Leu Leu Lys Cys Leu Glu Gin 210 215 220

Val Arg Lys He Gin Gly Asp Gly Ala Ala Leu Gin Glu Lys Leu Cys 225 230 235 240

Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His 245 250 255

Ser Leu Gly He Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gin Ala 260 265 270

Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser Gly Leu Phe Leu 275 280 285

Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly He Ser Pro Glu Leu Gly 290 295 300

Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala Asp Phe Ala Thr Thr 305 310 315 320 lie Trp Gin Gin Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gin Pro 325 330 335

Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gin Arg Arg Ala 340 345 350

Gly Gly Val Leu Val Ala Ser His Leu Gin Ser Phe Leu Glu Val Ser 355 360 365

Tyr Arg Val Leu Arg His Leu Ala Gin Pro 370 375 (2)序列編號NO: 748資料：

(i) 序列特性： (A) 長度：364胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 748

Ala Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala 15 10 15

Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin 20 25 30

Gly Leu Leu Glu Arg Val Asn Thr Glu He His Phe Val Thr Lys Cys 35 40 45

Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn He O:\92\92747.DOC -495- 200413407 50 55 60

Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro 65 70 75 80

Trp lie Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin 85 90 95

Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Gly 100 105 110

Ala Thr Ala Pro Thr Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie 115 120 125

Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu 130 135 140

Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Tyr Val Glu Gly Gly 145 150 155 160

Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie Ser Thr lie Asn Pro 165 170 175

Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Thr Pro 180 185 190

Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser Phe Leu Leu Lys Cys Leu 195 200 205

Glu Gin Val Arg Lys He Gin Gly Asp Gly Ala Ala Leu Gin Glu Lys 210 215 220

Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu 225 230 235 240

Gly His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser 245 250 255

Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser Gly Leu 260 265 270

Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly He Ser Pro Glu 275 280 285

Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala Asp Phe Ala 290 295 300

Thr Thr lie Trp Gin Gin Met Glu Glu Leu Gly Met Ala Pro Ala Leu 305 310 315 320

Gin Pro Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gin Arg 325 330 335

Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser Phe Leu Glu 340 345 350

Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro 355 360

(2)序列編號NO: 749資料： (i) 序列特性： (A) 長度：370胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 749

Ala Gin Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala 15 10 15 O:\92\92747.DOC -496-

Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin 20 25 30

Gly Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys 35 40 45

Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie 50 55 60

Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro 65 70 75 80

Trp lie Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin 85 90 95

Pro Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Gly 100 105 110

Ala Thr Ala Pro Thr Ala Gly Gin Pro Pro Leu Thr Gin Asp Cys Ser 115 120 125

Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys He Arg Glu 130 135 140

Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn 145 150 155 160

Pro Asn Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser 195 200 205

Phe Leu Leu Lys Cys Leu Glu Gin Val Arg Lys lie Gin Gly Asp Gly 210 215 220

Ala Ala Leu Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro 225 230 235 240

Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala Pro 245 250 255

Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser 260 265 270

Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu 275 280 285

Glu Gly lie Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu 290 295 300

Asp Val Ala Asp Phe Ala Thr Thr lie Trp Gin Gin Met Glu Glu Leu 305 310 315 320

Gly Met Ala Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe 325 330 335

Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His 340 345 350

Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala 355 360 365

Gin Pro 370 (2)序列編號NO: 750資料： (i)序列特性： (A) 長度：378胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 O:\92\92747.DOC -497- 200413407 (ii)分子類型：無 (xi)序列描述：序列編號NO: 750

Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 15 10 15

Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly 20 25 30

Leu Leu Glu Arg Val Asn Thr Glu He His Phe Val Thr Lys Cys Ala 35 40 45

Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn He Ser 50 55 60

Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp 65 70 75 80

He Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro 85 90 95

Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 100 105 110

Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 115 120 125

Ser Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro He Ser Ser Asp 130 135 140

Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr 145 150 155 160

Pro Val Thr Val Ala Ser Asn Leu Gin Tyr Val Glu Gly Gly Gly Gly 165 170 175

Ser Pro Gly Glu Pro Ser Gly Pro lie Ser Thr lie Asn Pro Ser Pro 180 185 190

Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Thr Pro Leu Gly 195 200 205

Pro Ala Ser Ser Leu Pro Gin Ser Phe Leu Leu Lys Cys Leu Glu Gin 210 215 220

Val Arg Lys He Gin Gly Asp Gly Ala Ala Leu Gin Glu Lys Leu Cys 225 230 235 240

Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His 245 250 255

Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gin Ala

260 265 270

Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser Gly Leu Phe Leu 275 280 285

Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie Ser Pro Glu Leu Gly 290 295 300

Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gin Arg Arg Ala 340 345 350

Gly Gly Val Leu Val Ala Ser His Leu Gin Ser Phe Leu Glu Val Ser 355 360 365

Tyr Arg Val Leu Arg His Leu Ala Gin Pro 370 375 (2)序列編號NO: 751資料： (i)序列特性： (A)長度：378胺基酸 O:\92\92747.DOC -498- 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 751

Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 1 5 10 15

Arg Trp Met Glu Arg Pro Lys Thr Val Ala Gly Ser Lys Met Gin Gly 20 25 30

Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala 35 40 45

Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser 50 55 60

Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 100 105 110

Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 115 120 125

Ser Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp 130 135 140

Phe Ala Val Lys He Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr 145 150 155 160

Pro Val Thr Val Ala Ser Asn Leu Gin Tyr Val Glu Gly Gly Gly Gly 165 170 175

Ser Pro Gly Glu Pro Ser Gly Pro lie Ser Thr lie Asn Pro Ser Pro 180 185 190

Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Thr Pro Leu Gly 195 200 205

Pro Ala Ser Ser Leu Pro Gin Ser Phe Leu Leu Lys Cys Leu Glu Gin 210 215 220

Val Arg Lys lie Gin Gly Asp Gly Ala Ala Leu Gin Glu Lys Leu Cys 225 230 235 240

Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His 245 250 255

Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gin Ala 260 265 270

Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser Gly Leu Phe Leu 275 280 285

Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie Ser Pro Glu Leu Gly 290 295 300

Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gin Arg Arg Ala 340 345 350

Gly Gly Val Leu Val Ala Ser His Leu Gin Ser Phe Leu Glu Val Ser 355 360 365

Tyr Arg Val Leu Arg His Leu Ala Gin Pro 370 375 -499-

O:\92\92747.DOC 200413407 (2)序列編號NO: 752資料： (i) 序列特性： (A) 長度：370胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 752

Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 15 10 15

Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly 20 25 30

Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala 35 40 45

Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser 50 55 60

Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp 65 70 75 80

He Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro 85 90 95

Asp Ser Ser Thr Leu Pro Pro Pro Trp Ser Pro Arg Pro Leu Gly Ala 100 105 110

Thr Ala Pro Thr Ala Gly Gin Pro Pro Leu Thr Gin Asp Cys Ser Phe 115 120 125

Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu 130 135 140

Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 145 150 155 160

Gin Tyr Val Glu Gly Gly Gly Gly Thr Pro Gly Glu Pro Ser Gly Pro 165 170 175

He Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser 180 185 190

Pro Asn Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser 195 200 205

Phe Leu Leu Lys Cys Leu Glu Gin Val Arg Lys He Gin Gly Asp Gly 210 215 220

Ala Ala Leu Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro 225 230 235 240

Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala Pro 245 250 255

Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser 260 265 270

Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu 275 280 285

Glu Gly He Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu 290 295 300

Asp Val Ala Asp Phe Ala Thr Thr He Trp Gin Gin Met Glu Glu Leu 305 310 315 320

Gly Met Ala Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe 325 330 335

Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His O:\92\92747.DOC -500- 200413407 340 345 350

Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala 355 360 365

Gin Pro 370 (2)序列編號NO: 753資料： (i) 序列特性： (A) 長度：347胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形

(ii) 分子類型：無 (xi)序列描述：序列編號NO: 753

Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 15 10 15

Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly 20 25 30

Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala 35 40 45

Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn He Ser 50 55 60

Val Glu Thr Val Phe His Arg Val Ser Gin Asp Gly Leu Asp Leu Leu 100 105 110

Thr Ser Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp 115 120 125

Phe Ala Val Lys He Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr 130 135 140

Pro Val Thr Val Ala Ser Asn Leu Gin Tyr Val Glu Gly Gly Gly Gly 145 150 155 160

Ser Pro Gly Gly Gly Ser Gly Gly Gly Ser Asn Met Ala Thr Pro Leu 165 170 175

Gly Pro Ala Ser Ser Leu Pro Gin Ser Phe Leu Leu Lys Ser Leu Glu 180s 185 190

Gin Val Arg Lys lie Gin Gly Asp Gly Ala Ala Leu Gin Glu Lys Leu 195 200 205

Cys Ala Thr Asn Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly 210 215 220

His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gin 225 230 235 240

Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser Gly Leu Phe 245 250 255

Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie Ser Pro Glu Leu 260 265 270

Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala Asp Phe Ala Thr 275 280 285

Thr lie Trp Gin Gin Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gin O:\92\92747.DOC -501- 200413407 290 295 300

Pro Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gin Arg Arg 305 310 315 320

Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser Phe Leu Glu Val 325 330 335

Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro 340 345 (2)序列編號NO: 754資料： (i) 序列特性： (A) 長度：384胺基酸 (B) 形式：胺基酸 (C) 股數：單

(D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 754

Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 15 10 15

Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly 20 25 30

Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala 35 40 45

Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser 50 55 60

Asp Ser Ser Thr Leu Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu 100 105 110

Pro Ser Gly Pro He Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu 115 120 125

Ser His Lys Ser Pro Asn Met Ala Thr Pro Leu Gly Pro Ala Ser Ser 130 135 140

Leu Pro Gin Ser Phe Leu Leu Lys Ser Leu Glu Gin Val Arg Lys lie 145 150 155 160

Gin Gly Asp Gly Ala Ala Leu Gin Glu Lys Leu Cys Ala Thr Tyr Lys 165 170 175

Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly lie 180 185 190

Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu Ala 195 200 205

Gly Cys Leu Ser Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu 210 215 220

Leu Gin Ala Leu Glu Gly lie Ser Pro Glu Leu Gly Pro Thr Leu Asp 225 230 235 240

Thr Leu Gin Leu Asp Val Ala Asp Phe Ala Thr Thr lie Trp Gin Gin 245 250 255

Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gin Pro Thr Gin Gly Ala 260 265 270

Met Pro Ala Phe Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly Val Leu O:\92\92747.DOC -502- 200413407 275 280 285

Val Ala Ser His Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg Val Leu 290 295 300

Arg His Leu Ala Gin Pro Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly 305 310 315 320

Glu Pro Ser Gly Pro lie Ser Thr lie Asn Pro Ser Pro Pro Ser Lys 325 330 335

Glu Ser His Lys Ser Pro Asn Met Ala Thr Gin Asp Cys Ser Phe Gin 340 345 350

His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser 355 360 365

Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin 370 375 380 (2)序列編號NO: 755資料： (i)序列特性：

(A) 長度：349胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (Π)分子類型：無 (xi)序列描述：序列編號NO: 755

Ala Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe 15 10 15

Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro 20 25 30

Val Thr Val Ala Ser Asn Leu Gin Glu Pro Lys Ser Pro Asp Thr His 35 40 45

Thr Ser Pro Pro Ser Pro Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro 50 55 60

Gin Ser Phe Leu Leu Lys Ser Leu Glu Gin Val Arg Lys lie Gin Gly 65 70 75 80

Asp Gly Ala Ala Leu Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys 85 90 95

His Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly lie Pro Trp 100 105 110

Ala Pro Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys 115 120 125

Leu Ser Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin 130 135 140

Ala Leu Glu Gly lie Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu 145 150 155 160

Gin Leu Asp Val Ala Asp Phe Ala Thr Thr lie Trp Gin Gin Met Glu 165 170 175

Glu Leu Gly Met Ala Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro 180 185 190

Ala Phe Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala 195 200 205

Ser His Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His 210 215 220 O:\92\92747.DOC -503- 200413407

Leu Ala Gin Pro Ser Ala Glu Pro Lys Ser Pro Asp Thr His Thr Ser 225 230 235 240

Pro Pro Ser Pro Gly Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly 245 250 255

Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr 260 265 270

Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu 275 280 285

He His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu 290 295 300

Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu 305 310 315 320

Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg 325 330 335

Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu 340 345 (2)序列編號NO·· 756資料：

(i) 序列特性： (A) 長度：347胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D )拓撲結構·線形 (ii) 分子類型：無 (xi)序列描述··序列編號NO: 756

Ala Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe 15 10 15

Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro 20 25 30

Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu 35 40 45

Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val 50 55 60

Ala Gly Ser Lys Met Gin Gly Trp Gin Gly Arg Val Asn Thr Glu lie 65 70 75 80

His Phe Val Thr Lys Cys Ala Phe Pro Lys Ser Pro Asp Thr His Thr 85 90 95

Ser Pro Pro Ser Pro Gly Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro 100 105 110

Gin Ser Phe Leu Leu Lys Ser Leu Glu Gin Val Arg Lys lie Gin Gly 115 120 125

Asp Gly Ala Ala Leu Gin Glu Lys Leu Cys Ala Tyr Lys Leu Cys His 130 135 140

Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala 145 150 155 160

Pro Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu 165 170 175

Ser Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala 180 185 190

Leu Glu Gly lie Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin 195 200 205 O:\92\92747.DOC -504-

Leu Asp Val Ala Asp Phe Ala Thr Thr He Trp Gin Gin Met Glu Glu 210 215 220

Leu Gly Met Ala Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala 225 230 235 240

Phe Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser 245 250 255

His Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu 260 265 270

Ala Gin Pro Ser Ala Glu Pro Lys Ser Pro Asp Thr His Thr Ser Pro 275 280 285

Pro Ser Pro Gly Lys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe 290 295 300

Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu 305 310 315 320

Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys Leu 325 330 335

Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu 340 345 (2)序列編號NO: 757資料： (i) 序列特性： (A) 長度：355胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 757

Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 15 10 15

Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly 20 25 30

Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Ser Ala 35 40 45

Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser 50 55 60

Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp 65 70 75 80

He Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro 85 90 95

Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 100 105 110

Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp Ser Ser Phe 115 120 125

Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys He Arg Glu Leu 130 135 140

Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 145 150 155 160

Gin Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Gly Gly Ser Gly Gly 165 170 175

Gly Ser Asn Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin 180 185 190 -505-

O:\92\92747.DOC 200413407

Ser Phe Leu Leu Lys Ser Leu Glu Gin Val Arg Lys He Gin Gly Asp 195 200 205

Gly Ala Ala Leu Gin Glu Lys Leu Cys Ala Thr Asn Lys Leu Cys His 210 215 220

Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala 225 230 235 240

Pro Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu 245 250 255

Ser Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala 260 265 270

Leu Glu Gly He Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin 275 280 285

Leu Asp Val Ala Asp Phe Ala Thr Thr lie Trp Gin Gin Met Glu Glu 290 295 300

Leu Gly Met Ala Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala 305 310 315 320

Phe Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser 325 330 335

His Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu 340 345 350

Ala Gin Pro 355 (2)序列編號NO: 758資料： (i) 序列特性： (A) 長度·· 370胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無

(xi)序列描述：序列編號NO: 758

Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser Phe Leu Leu 15 10 15

Lys Ser Leu Glu Gin Val Arg Lys He Gin Gly Asp Gly Ala Ala Leu 20 25 30

Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 35 40 45

Val Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser 50 55 60

Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His 65 70 75 80

Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie 85 90 95

Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala 100 105 110

Asp Phe Ala Thr Thr lie Trp Gin Gin Met Glu Glu Leu Gly Met Ala 115 120 125

Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala 130 135 140

Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser 145 150 155 160 O:\92\92747.DOC -506- 200413407

Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro Tyr 165 170 175

Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie Ser 180 185 190

Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn 195 200 205

Met Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala 210 215 220

Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin 225 230 235 240

Gly Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Ser 245 250 255

Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie 260 265 270

Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro 275 280 285

Trp lie Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin 290 295 300

Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly

305 310 315 320

Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp Ser Ser 325 330 335

Phe Gin His Ser Pro He Ser Ser Asp Phe Ala Val Lys lie Arg Glu 340 345 350

Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn 355 360 365

Leu Gin 370 (2)序列編號NO: 759資料： (i) 序列特性： (A) 長度：355胺基酸 (B) 形式：胺基酸

(C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO·. 759

Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 1 5 10 15

Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly 20 25 30

Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala 35 40 45

Phe Gin Pro Pro Pro Ser Ser Leu Arg Phe Val Gin Thr Asn lie Ser 50 55 60

Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp 65 70 75 80

He Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Ser Gin Pro 85 90 95

Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 100 105 110 O:\92\92747.DOC -507 200413407

Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp Cys Ser Phe 115 120 125

Gin His Ser Pro He Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu 130 135 140

Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 145 150 155 160

Gin Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Gly Gly Ser Gly Gly 165 170 175

Gly Ser Asn Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin 180 185 190

Ser Phe Leu Leu Lys Ser Leu Glu Gin Val Arg Lys lie Gin Gly Asp 195 200 205

Gly Ala Ala Leu Gin Glu Lys Leu Cys Ala Thr Asn Lys Leu Cys His 210 215 220

Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala 225 230 235 240

Pro Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu 245 250 255

Ser Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala 260 265 270

Leu Glu Gly lie Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin 275 280 285

Leu Asp Val Ala Asp Phe Ala Thr Thr lie Trp Gin Gin Met Glu Glu 290 295 300

Leu Gly Met Ala Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala 305 310 315 320

Phe Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser 325 330 335

His Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu 340 345 350

Ala Gin Pro 355 (2)序列編號NO: 760資料： (i) 序列特性：

(A) 長度·· 370胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO·. 760

Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser Phe Leu Leu 15 10 15

Lys Ser Leu Glu Gin Val Arg Lys lie Gin Gly Asp Gly Ala Ala Leu 20 25 30

Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 35 40 45

Val Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser 50 55 60

Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His 65 70 75 80 O:\92\92747.DOC 508- 200413407

Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie 85 90 95

Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala 100 105 110

Asp Phe Ala Thr Thr lie Trp Gin Gin Met Glu Glu Leu Gly Met Ala 115 120 125

Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala 130 135 140

Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser 145 150 155 160

Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro Tyr 165 170 175

Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He Ser 180 185 190

Thr He Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn 195 200 205

Met Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala 210 215 220

Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin

225 230 235 240

Gly Leu Leu Glu Arg Val Asn Thr Glu He His Phe Val Thr Lys Cys 245 250 255

Ala Phe Gin Pro Pro Pro Ser Ser Leu Arg Phe Val Gin Thr Asn lie 260 265 270

Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro 275 280 285

Trp lie Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Ser Gin 290 295 300

Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 305 310 315 320

Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp Cys Ser 325 330 335

Phe Gin His Ser Pro He Ser Ser Asp Phe Ala Val Lys lie Arg Glu 340 345 350

Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn 355 360 365

Leu Gin 370

(2)序列編號NO: 761資料： (i) 序列特性： (A) 長度：334胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 761

Ala Thr Gin Asp Ser Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe 15 10 15

Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro 20 25 30 O:\92\92747.DOC 509 200413407

Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu 35 40 45

Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val 50 55 60

Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu He 65 70 75 80

His Phe Val Thr Lys Ser Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg 85 90 95

Phe Val Gin Thr Asn He Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin 100 105 110

Leu Val Ala Leu Lys Pro Trp He Thr Arg Gin Asn Phe Ser Arg Cys 115 120 125

Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Tyr Val Glu Gly 130 135 140

Gly Gly Gly Ser Pro Gly Gly Gly Ser Gly Gly Gly Ser Asn Met Ala 145 150 155 160

Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser Phe Leu Leu Lys 165 170 175

Ser Leu Glu Gin Val Arg Lys lie Gin Gly Asp Gly Ala Ala Leu Gin

180 185 190

Glu Lys Leu Cys Ala Thr Asn Lys Leu Cys His Pro Glu Glu Leu Val 195 200 205

Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys 210 215 220

Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser 225 230 235 240

Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie Ser 245 250 255

Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala Asp 260 265 270

Phe Ala Thr Thr lie Trp Gin Gin Met Glu Glu Leu Gly Met Ala Pro 275 280 285

Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Phe 290 295 300

Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser Phe 305 310 315 320

Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro 325 330

(2)序列編號NO: 762資料： (i) 序列特性： (A) 長度：334胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 762

Ala Thr Gin Asp Cys Ser Phe Gin His Ser Pro He Ser Ser Asp Phe 15 10 15

Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro 20 25 30 O:\92\92747.DOC -510-

Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu 35 40 45

Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val 50 55 60

Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie 65 70 75 80

His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Ser Leu Arg 85 90 95

Phe Val Gin Thr Asn He Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin 100 105 110

Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys 115 120 125

Leu Glu Leu Gin Ser Gin Pro Asp Ser Ser Thr Leu Tyr Val Glu Gly 130 135 140

Gly Gly Gly Ser Pro Gly Gly Gly Ser Gly Gly Gly Ser Asn Met Ala 145 150 155 160

Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser Phe Leu Leu Lys 165 170 175

Ser Leu Glu Gin Val Arg Lys lie Gin Gly Asp Gly Ala Ala Leu Gin 180 185 190

Glu Lys Leu Cys Ala Thr Asn Lys Leu Cys His Pro Glu Glu Leu Val 195 200 205

Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys 210 215 220

Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser 225 230 235 240

Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly He Ser 245 250 255

Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala Asp 260 265 270

Phe Ala Thr Thr lie Trp Gin Gin Met Glu Glu Leu Gly Met Ala Pro 275 280 285

Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Phe 290 295 300

Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser Phe 305 310 315 320

Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro 325 330 (2)序列編號NO: 763資料： (i) 序列特性： (A) 長度：326胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 763

Ala Thr Gin Asp Cys Ser Phe Gin His Ser Pro He Ser Ser Asp Phe 15 10 15

Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro 20 25 30 -511-

O:\92\92747.DOC 200413407

Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu 35 40 45

Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val 50 55 60

Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie 65 70 75 80

His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg 85 90 95

Phe Val Gin Thr Asn He Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin 100 105 110

Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys 115 120 125

Leu Glu Leu Gin Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Gly Gly 130 135 140

Ser Gly Gly Gly Ser Asn Met Ala Thr Pro Leu Gly Pro Ala Ser Ser 145 150 155 160

Leu Pro Gin Ser Phe Leu Leu Lys Ser Leu Glu Gin Val Arg Lys lie 165 170 175

Gin Gly Asp Gly Ala Ala Leu Gin Glu Lys Leu Cys Ala Thr Asn Lys 180 185 190

Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly lie 195 200 205

Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu Ala 210 215 220

Gly Cys Leu Ser Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu 225 230 235 240

Leu Gin Ala Leu Glu Gly lie Ser Pro Glu Leu Gly Pro Thr Leu Asp 245 250 255

Thr Leu Gin Leu Asp Val Ala Asp Phe Ala Thr Thr lie Trp Gin Gin 260 265 270

Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gin Pro Thr Gin Gly Ala 275 280 285

Met Pro Ala Phe Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly Val Leu 290 295 300

Val Ala Ser His Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg Val Leu 305 310 315 320

Arg His Leu Ala Gin Pro 325

(2)序列編號NO: 764資料： (i) 序列特性： (A) 長度：334胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 764

Ala Thr Gin Asp Cys Ser Phe Gin His Ser Pro He Ser Ser Asp Phe 15 10 15

Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro O:\92\92747.DOC -512 200413407 20 25 30

Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu 35 40 45

Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val 50 55 60

Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie 65 70 75 80

His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg 85 90 95

Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin 100 105 110

Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys 115 120 125

Leu Glu Leu Gin Ser Gin Pro Asp Ser Ser Thr Leu Tyr Val Glu Gly 130 135 140

Gly Gly Gly Ser Pro Gly Gly Gly Ser Gly Gly Gly Ser Asn Met Ala 145 150 155 160

Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser Phe Leu Leu Lys 165 170 175

Ser Leu Glu Gin Val Arg Lys lie Gin Gly Asp Gly Ala Ala Leu Gin 180 185 190

Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val 195 200 205

Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys 210 215 220

Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser 225 230 235 240

Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie Ser 245 250 255

Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala Asp 260 265 270

Phe Ala Thr Thr He Trp Gin Gin Met Glu Glu Leu Gly Met Ala Pro 275 280 285

Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Phe 290 295 300

Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser Phe 305 310 315 320

Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro 325 330

(2)序列編號NO: 765資料： (i)序列特性： (A) 長度：334胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (Π)分子類型：無 (xi)序列描述：序列編號NO: 765

Ala Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe 15 10 15

Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro O:\92\92747.DOC -513- 200413407 20 25 30

Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu 35 40 45

Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val 50 55 60

Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie 65 70 75 80

His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg 85 90 95

Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin 100 105 110

Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Arg 115 120 125

Leu Glu Leu Gin Ser Gin Pro Asp Ser Ser Thr Leu Tyr Val Glu Gly 130 135 140

Gly Gly Gly Ser Pro Gly Gly Gly Ser Gly Gly Gly Ser Asn Met Ala 145 150 155 160

Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser Phe Leu Leu Lys 165 ' 170 175

Ser Leu Glu Gin Val Arg Lys lie Gin Gly Asp Gly Ala Ala Leu Gin 180 185 190

Glu Lys Leu Cys Ala Thr Asn Lys Leu Cys His Pro Glu Glu Leu Val 195 200 205

Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys 210 215 220

Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser 225 230 235 240

Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie Ser 245 250 255

Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala Asp 260 265 270

Phe Ala Thr Thr lie Trp Gin Gin Met Glu Glu Leu Gly Met Ala Pro 275 280 285

Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Phe 290 295 300

Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser Phe 305 310 315 320

Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro 325 330

(2)序列編號NO: 766資料： (i) 序列特性： (A) 長度：352胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 766

Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 15 10 15

Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly O:\92\92747.DOC -514- 200413407 20 25 30

Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala 35 40 45

Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser 50 55 60

Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 100 105 110

Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp Cys Ser Phe 115 120 125

Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu 130 135 140

Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 145 150 155 160

Gin Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Gly Gly Ser Gly Gly 165 170 175

Gly Ser Asn Met Ala Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala 180 185 190

Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser 195 200 205

Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro Ser 210 215 220

Gly Gly Ser Gly Gly Ser Gin Ser Phe Leu Leu Lys Ser Leu Glu Gin 225 230 235 240

Val Arg Lys He Gin Gly Asp Gly Ala Ala Leu Gin Glu Lys Leu Cys 245 250 255

Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His 260 265 270

Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gin Ala 275 280 285

Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His Ser Gly Leu Phe Leu 290 295 300

Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly He Ser Pro Glu Leu Gly 305 310 315 320

Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala Asp Phe Ala Thr Thr 325 330 335

He Trp Gin Gin Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gin Pro 340 345 350 (2)序列編號NO: 767資料： (i)序列特性： (A) 長度：367胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (Π)分子類型：無 (xi)序列描述：序列編號NO·. 767

Ala Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Phe Gin Arg Arg O:\92\92747.DOC 515- 15 10 15

Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser Phe Leu Glu Val 20 25 30

Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro Ser Gly Gly Ser Gly 35 40 45

Gly Ser Gin Ser Phe Leu Leu Lys Ser Leu Glu Gin Val Arg Lys lie 50 55 60

Gin Gly Asp Gly Ala Ala Leu Gin Glu Lys Leu Cys Ala Thr Tyr Lys 65 70 75 80

Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly lie 85 90 95

Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu Ala 100 105 110

Gly Cys Leu Ser Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu 115 120 125

Leu Gin Ala Leu Glu Gly He Ser Pro Glu Leu Gly Pro Thr Leu Asp 130 135 140

Thr Leu Gin Leu Asp Val Ala Asp Phe Ala Thr Thr lie Trp Gin Gin 145 150 155 160

Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gin Pro Tyr Val Glu Gly 165 170 175

Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie Ser Thr He Asn 180 185 190

Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Asp 195 200 205

Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin Arg Trp 210 215 220

Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly Leu Leu 225 230 235 240

Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala Phe Gin 245 250 255

Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser Arg Leu 260 265 270

Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp lie Thr 275 280 285

Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser 290 295 300

Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 305 310 315 320

Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp Cys Ser Phe Gin His 325 330 335

Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser Asp 340 345 350

Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin 355 360 365 (2)序列編號NO: 768資料： (i) 序列特性： (A) 長度：344胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 O:\92\92747.DOC -516- (xi)序列描述：序列編號NO: 768

Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 15 10 15

Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly 20 25 30

Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala 35 40 45

Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser 50 55 60

Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp 65 70 75 80

He Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro 85 90 95

Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 100 105 110

Ser Gly Gly Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser 115 120 125

Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin 130 135 140

Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Tyr Val Glu Gly Gly 145 150 155 160

Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He Ser Thr He Asn Pro 165 170 175

Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Asp Glu 180 185 190

Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met 195 200 205

Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu 210 215 220

Arg Val Asn Thr Glu He His Phe Val Thr Lys Cys Ala Phe Gin Pro 225 230 235 240

Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu 245 250 255

Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp He Thr Arg 260 265 270

Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser 275 280 285

Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 290 295 300

Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe 305 310 315 320

Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro 325 330 335

Val Thr Val Ala Ser Asn Leu Gin 340 (2)序列編號NO·· 769資料： (i)序列特性： (A) 長度：335胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 517-

O:\92\92747.DOC 200413407 (Π)分子類型：無 (xi)序列描述：序列編號NO: 769

Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 15 10 15

Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly 20 25 30

Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala 35 40 45

Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn He Ser 50 55 60

Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 100 105 110

Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp Cys Ser Phe 115 120 125

Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu 130 135 140

Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 145 150 155 160

Pro Asn Met Ala Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser 195 200 205

Ser Asp Phe Ala Val Lys He Arg Glu Leu Ser Asp Tyr Leu Leu Gin 210 215 220

Asn Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys 225 230 235 240

Gly Gly Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu 245 250 255

Lys Thr Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn 260 265 270

Thr Glu lie His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser 275 280 285

Cys Leu Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr 290 295 300

Ser Glu Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe 305 310 315 320

Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu 325 330 335 (2)序列編號NO: 770資料： (i)序列特性： (A) 長度：550胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 O:\92\92747.DOC 518- 200413407 (ii)分子類型：無 (xi)序列描述：序列編號NO: 770

Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 15 10 15

Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly 20 25 30

Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala 35 40 45

Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser 50 55 60

Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp 65 70 75 80

He Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro 85 90 95

Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 100 105 110

Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp Cys Ser Phe 115 120 125

Gin His Ser Pro He Ser Ser Asp Phe Ala Val Lys He Arg Glu Leu 130 135 140

Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 145 150 155 160

Gin Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Gly Gly Ser Gly Gly 165 170 175

Gly Ser Asn Met Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin 180 185 190

Ser Phe Leu Leu Lys Ser Leu Glu Gin Val Arg Lys He Gin Gly Asp 195 200 205

Gly Ala Ala Leu Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His 210 215 220

Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly He Pro Trp Ala 225 230 235 240

Pro Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu 245 250 255

Ser Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala 260 265 270

Leu Glu Gly He Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin 275 280 285

Leu Asp Val Ala Asp Phe Ala Thr Thr He Trp Gin Gin Met Glu Glu 290 295 300

Leu Gly Met Ala Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala 305 310 315 320

Phe Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser 325 330 335

His Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu 340 345 350

Ala Gin Pro Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser 355 360 365

Gly Pro lie Ser Thr He Asn Pro Ser Pro Pro Ser Lys Glu Ser His 370 375 380

Lys Ser Pro Asn Met Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg 385 390 395 400

Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly 405 410 415

Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu He His Phe 420 425 430

Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val O:\92\92747.DOC -519- 200413407 435 440 445

Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val 450 455 460

Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu 465 470 475 480

Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly 485 490 495

Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr 500 505 510

Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala Val 515 520 525

Lys He Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr 530 535 540

Val Ala Ser Asn Leu Gin 545 550 (2)序列編號NO: 771資料：

(i) 序列特性： (A) 長度：544胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 771

Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser Phe Leu Leu 15 10 15

Lys Ser Leu Glu Gin Val Arg Lys He Gin Gly Asp Gly Ala Ala Leu 20 25 30

Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 35 40 45

Val Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser 50 55 60

Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His 65 70 75 80

Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie 85 90 95

Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala 100 105 110

Asp Phe Ala Thr Thr He Trp Gin Gin Met Glu Glu Leu Gly Met Ala 115 120 125

Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala 130 135 140

Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser 145 150 155 160

Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro Tyr 165 170 175

Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie Ser 180 185 190

Thr He Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn 195 200 205

Met Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala O:\92\92747.DOC -520 200413407 210 215 220

Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin 225 230 235 240

Gly Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys 245 250 255

Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie 260 265 270

Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro 275 280 285

Trp He Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin 290 295 300

Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 305 310 315 320

Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp Cys Ser 325 330 335

Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu 340 345 350

Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn 355 360 365

Leu Gin Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly 370 375 380

Pro lie Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys 385 390 395 400

Ser Pro Asn Met Ala Thr Gin Asp Cys Ser Phe Gin His Ser Pro He 405 410 415

Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu 420 425 430

Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu 435 440 445

Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg 450 455 460

Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val 465 470 475 480

Asn Thr Glu lie His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro 485 490 495

Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu 500 505 510

Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp lie Thr Arg Gin Asn 515 520 525

Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu 530 535 540 (2)序列編號NO: 772資料： (i) 序列特性： (A) 長度：565胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 772 O:\92\92747.DOC 521- 200413407

Ala Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gin Ser Phe Leu Leu 15 10 15

Lys Ser Leu Glu Gin Val Arg Lys lie Gin Gly Asp Gly Ala Ala Leu 20 25 30

Gin Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 35 40 45

Val Leu Leu Gly His Ser Leu Gly lie Pro Trp Ala Pro Leu Ser Ser 50 55 60

Cys Pro Ser Gin Ala Leu Gin Leu Ala Gly Cys Leu Ser Gin Leu His 65 70 75 80

Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie 85 90 95

Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gin Leu Asp Val Ala 100 105 110

Asp Phe Ala Thr Thr lie Trp Gin Gin Met Glu Glu Leu Gly Met Ala 115 120 125

Pro Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala 130 135 140

Phe Gin Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gin Ser

145 150 155 160

Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gin Pro Tyr 165 170 175

Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie Ser 180 185 190

Thr He Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn 195 200 205

Met Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala 210 215 220

Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin 225 230 235 240

Gly Leu Leu Glu Arg Val Asn Thr Glu He His Phe Val Thr Lys Cys 245 250 255

Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie 260 265 270

Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro 275 280 285

Trp He Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin 290 295 300

Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly

305 310 315 320

Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp Cys Ser 325 330 335

Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys He Arg Glu 340 345 350

Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn 355 360 365

Leu Gin Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly 370 375 380

Pro lie Ser Thr He Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys 385 390 395 400

Ser Pro Asn Met Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu 405 410 415

Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser 420 425 430

Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val 435 440 445

Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin 450 455 460

Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala 465 470 475 480

Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu O:\92\92747.DOC •522- 485 490 495

Gin Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly 500 505 510

Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin 515 520 525

Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys 530 535 540 lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val 545 550 555 560

Ala Ser Asn Leu Gin 565 (2)序列編號NO: 773資料： (i) 序列特性： (A) 長度：502胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 773

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg 15 10 15

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Asp Glu Asp Val 20 25 30

Ser lie Leu Met Asp Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe 35 40 45

Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie He Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110

Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie 115 120 125

Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 130 135 140

Asn Met Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu 145 150 155 160

Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met 165 170 175

Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys 180 185 190

Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn 195 200 205

He Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys 210 215 220

Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys 225 230 235 240

Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly -523-

O:\92\92747.DOC 200413407 245 250 255

Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp Cys 260 265 270

Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg 275 280 285

Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser 290 295 300

Asn Leu Gin Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser 305 310 315 320

Gly Pro lie Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu Ser His 325 330 335

Lys Ser Pro Asn Met Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg 340 345 350

Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly 355 360 365

Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie His Phe 370 375 380

Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val 385 390 395 400

Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val 405 410 415

Ala Leu Lys Pro Trp lie Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu 420 425 430

Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly 435 440 445

Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr 450 455 460

Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala Val 465 470 475 480

Lys He Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr 485 490 495

Val Ala Ser Asn Leu Gin 500 (2)序列編號NO: 774資料： (i) 序列特性：

(A) 長度：562胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 774

Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 15 10 15

Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly 20 25 30

Leu Leu Glu Arg Val Asn Thr Glu He His Phe Val Thr Lys Cys Ala 35 40 45

Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser 50 55 60

Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp O:\92\92747.DOC -524- 200413407 65 70 75 80

He Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro 85 90 95

Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 100 105 110

Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp Cys Ser Phe 115 120 125

Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys He Arg Glu Leu 130 135 140

Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 145 150 155 160

Gin Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Gly Gly Ser Gly Gly 165 170 175

Gly Ser Asn Met Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu 180 185 190

Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser 195 200 205

Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val 210 215 220

Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin 225 230 235 240

Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala 245 250 255

Leu Lys Pro Trp He Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu 260 265 270

Gin Cys Gin Pro Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly 275 280 285

Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin 290 295 300

Asp Cys Ser Phe Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys 305 310 315 320 lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val 325 330 335

Ala Ser Asn Leu Gin Tyr Val Glu Gly Gly Gly Gly Ser Pro Gly Glu 340 345 350

Pro Ser Gly Pro He Ser Thr lie Asn Pro Ser Pro Pro Ser Lys Glu 355 360 365

Ser His Lys Ser Pro Asn Met Ala Thr Pro Leu Gly Pro Ala Ser Ser 370 375 380

Leu Pro Gin Ser Phe Leu Leu Lys Cys Leu Glu Gin Val Arg Lys lie 385 390 395 400

Gin Gly Asp Gly Ala Ala Leu Gin Glu Lys Leu Cys Ala Thr Tyr Lys 405 410 415

Leu Cys His Pro Glu Glu Leu Val Leu Leu Gly His Ser Leu Gly lie 420 425 430

Pro Trp Ala Pro Leu Ser Ser Cys Pro Ser Gin Ala Leu Gin Leu Ala 435 440 445

Gly Cys Leu Ser Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu 450 455 460

Leu Gin Ala Leu Glu Gly lie Ser Pro Glu Leu Gly Pro Thr Leu Asp 465 470 475 480

Thr Leu Gin Leu Asp Val Ala Asp Phe Ala Thr Thr He Trp Gin Gin 485 490 495

Met Glu Glu Leu Gly Met Ala Pro Ala Leu Gin Pro Thr Gin Gly Ala 500 505 510

Met Pro Ala Phe Ala Ser Ala Phe Gin Arg Arg Ala Gly Gly Val Leu 515 520 525

Val Ala Ser His Leu Gin Ser Phe Leu Glu Val Ser Tyr Arg Val Leu 530 535 540

Arg His Leu Ala Gin Pro Ser Thr Pro Ser Thr Pro Gly Ser Glu Phe 545 550 555 560 O:\92\92747.DOC 525- 200413407

Gly Ser (2)序列編號NO: 775資料： (i)序列特性： (A) 長度：490胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (Π)分子類型：無 (xi)序列描述：序列編號NO: 775

Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 15 10 15

Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly 20 25 30

Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala 35 40 45

Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser 50 55 60

Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 100 105 110

Ser Gly Gly Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro lie Ser 115 120 125

Ser Asp Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin 130 135 140

Asp Tyr Pro Val Thr Val Ala Ser Asn Leu Gin Tyr Val Glu Gly Gly 145 150 155 160

Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro lie Ser Thr lie Asn Pro 165 170 175

Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala Asn Cys 180 185 190

Ser lie Met lie Asp Glu lie lie His His Leu Lys Arg Pro Pro Asn 195 200 205

Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met Asp lie Leu 210 215 220

Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe Val Arg Ala 225 230 235 240

Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala He Leu Arg Asn 245 250 255

Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin Tyr Val Glu 290 295 300

Gly Gly Gly Gly Ser Pro Gly Glu Pro Ser Gly Pro He Ser Thr lie 305 310 315 320

Asn Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro Asn Met Ala O:\92\92747.DOC -526- 200413407 325 330 335

Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin Arg 340 345 350

Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly Leu 355 360 365

Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala Phe 370 375 380

Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn He Ser Arg 385 390 395 400

Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp lie 405 410 415

Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro Asp 420 425 430

Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 435 440 445

Gly Gly Gly Thr Gin Asp Cys Ser Phe Gin His Ser Pro He Ser Ser 450 455 460

Asp Phe Ala Val Lys lie Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp 465 470 475 480

Tyr Pro Val Thr Val Ala Ser Asn Leu Gin 485 490 (2)序列編號NO: 776資料： (i) 序列特性： (A) 長度：398胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 776

Ala Asp Glu Glu Leu Cys Gly Gly Leu Trp Arg Leu Val Leu Ala Gin 15 10 15

Arg Trp Met Glu Arg Leu Lys Thr Val Ala Gly Ser Lys Met Gin Gly 20 25 30

Leu Leu Glu Arg Val Asn Thr Glu lie His Phe Val Thr Lys Cys Ala 35 40 45

Phe Gin Pro Pro Pro Ser Cys Leu Arg Phe Val Gin Thr Asn lie Ser 50 55 60

Arg Leu Leu Gin Glu Thr Ser Glu Gin Leu Val Ala Leu Lys Pro Trp 65 70 75 80

He Thr Arg Gin Asn Phe Ser Arg Cys Leu Glu Leu Gin Cys Gin Pro 85 90 95

Asp Ser Ser Thr Leu Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 100 105 110

Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Thr Gin Asp Cys Ser Phe 115 120 125

Gin His Ser Pro lie Ser Ser Asp Phe Ala Val Lys lie Arg Glu Leu 130 135 140

Ser Asp Tyr Leu Leu Gin Asp Tyr Pro Val Thr Val Ala Ser Asn Leu 145 150 155 160

Gin Glu Phe Lys Leu Glu Pro Arg Gly Pro Thr He Lys Pro Cys Pro -527-

O:\92\92747.DOC 200413407 165 170 175

Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe 180 185 190 lie Phe Pro Pro Lys lie Lys Asp Val Leu Met He Ser Leu Ser Pro 195 200 205 lie Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val 210 215 220

Gin lie Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gin Thr 225 230 235 240

Gin Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Ala Val Ser Ala 245 250 255

Leu Pro lie Gin His Gin Asp Trp Met Ser Gly Lys Glu Phe Lys Cys 260 265 270

Lys Val Asn Asn Lys Asp Leu Pro Ala Pro lie Glu Arg Thr He Ser 275 280 285

Lys Pro Lys Gly Ser Val Arg Ala Pro Gin Val Tyr Val Leu Pro Pro 290 295 300

Pro Glu Glu Glu Met Thr Lys Lys Gin Val Thr Leu Thr Cys Met Val 305 310 315 320

Thr Asp Phe Met Pro Glu Asp He Tyr Val Glu Trp Thr Asn Asn Gly 325 330 335

Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp 340 345 350

Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp 355 360 365

Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His 370 375 380

Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 385 390 395 (2)序列編號NO·· 777資料： (i) 序列特性： (A) 長度：377胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 777

Ala Thr Gin Asp Cys Ser Phe Gin His Ser Pro He Ser Ser Asp Phe 15 10 15

Ala Val Lys He Arg Glu Leu Ser Asp Tyr Leu Leu Gin Asp Tyr Pro 20 25 30

Val Thr Val Ala Ser Asn Leu Gin Asp Glu Glu Leu Cys Gly Gly Leu 35 40 45

Trp Arg Leu Val Leu Ala Gin Arg Trp Met Glu Arg Leu Lys Thr Val 50 55 60

Ala Gly Ser Lys Met Gin Gly Leu Leu Glu Arg Val Asn Thr Glu lie 65 70 75 80

His Phe Val Thr Lys Cys Ala Phe Gin Pro Pro Pro Ser Cys Leu Arg 85 90 95

Phe Val Gin Thr Asn lie Ser Arg Leu Leu Gin Glu Thr Ser Glu Gin 528-

O:\92\92747.DOC 200413407 100 105 110

Leu Val Ala Leu Lys Pro Trp He Thr Arg Gin Asn Phe Ser Arg Cys 115 120 125

Leu Glu Leu Gin Cys Gin Pro Asp Ser Ser Thr Leu Glu Phe Lys Leu 130 135 140

Glu Pro Arg Gly Pro Thr lie Lys Pro Cys Pro Pro Cys Lys Cys Pro 145 150 155 160

Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe He Phe Pro Pro Lys 165 170 175 lie Lys Asp Val Leu Met lie Ser Leu Ser Pro lie Val Thr Cys Val 180 185 190

Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gin He Ser Trp Phe 195 200 205

Val Asn Asn Val Glu Val His Thr Ala Gin Thr Gin Thr His Arg Glu 210 215 220

Asp Tyr Asn Ser Thr Leu Arg Ala Val Ser Ala Leu Pro lie Gin His 225 230 235 240

Gin Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 245 250 255

Asp Leu Pro Ala Pro lie Glu Arg Thr lie Ser Lys Pro Lys Gly Ser 260 265 270

Val Arg Ala Pro Gin Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met 275 280 285

Thr Lys Lys Gin Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro 290. 295 300

Glu Asp He Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn 305 310 315 320

Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met 325 330 335

Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser 340 345 350

Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr 355 360 365

Lys Ser Phe Ser Arg Thr Pro Gly Lys 370 375 (2)序列編號NO: 778資料：

(i) 序列特性： (A) 長度：4胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 778

Gly Gly Gly Ser 1 (2)序列編號NO: 779資料： O:\92\92747.DOC -529 200413407 (i) 序列特性： (A) 長度· 8胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 779

Gly Gly Gly Ser Gly Gly Gly Ser 1 5 (2)序列編號NO: 780資料：春 (i) 序列特性： (A) 長度：12胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 780

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 1 5 10 (2)序列編號NO: 781資料： ® (i) 序列特性： (A) 長度：7胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 781

Ser Gly Gly Ser Gly Gly Ser 1 5 O:\92\92747.DOC -530- 200413407 (2)序列編號NO: 782資料： (i)序列特性： (A) 長度：5胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (Π)分子類型：無 (xi)序列描述：序列編號NO: 782

Glu Phe Gly Asn Met 1 5 (2)序列編號NO: 783資料： (i) 序列特性： (A) 長度：6胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 783

Glu Phe Gly Gly Asn Met 1 5 (2)序列編號NO: 784資料： (i) 序列特性： (A) 長度：9胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 784 O:\92\92747.DOC -531- 200413407

Glu Phe Gly Gly Asn Gly Gly Asn Met 1 5 (2)序列編號NO: 785資料： (i) 序列特性： (A) 長度：7胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 785

Gly Gly Ser Asp Met Ala Gly 1 5 (2)序列編號NO: 786資料： (i) 序列特性： (A) 長度：5胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 786

Ser Gly Gly Asn Gly 1 5 (2)序列編號NO: 787資料： (i)序列特性： (A) 長度：10胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 O:\92\92747.DOC -532- 200413407 (ii)分子類型：無 (xi)序列描述：序列編號NO: 787

Ser Gly Gly Asn Gly Ser Gly Gly Asn Gly 1 5 10 (2)序列編號NO: 788資料： (i) 序列特性： (A) 長度：15胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形籲 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 788

Ser Gly Gly Asn Gly Ser Gly Gly Asn Gly Ser Gly Gly Asn Gly 1 5 10 15 (2)序列編號NO: 789資料： (i) 序列特性： (A) 長度：10胺基酸 (B) 形式：胺基酸

(C) 股數：單 I (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 789

Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly 1 5 10 (2)序列編號NO: 790資料： (i)序列特性： (A) 長度：15胺基酸 (B) 形式：胺基酸 (C) 股數：單 O:\92\92747.DOC 533- 200413407 (D)拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 790

Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly Ser Gly Gly Ser Gly 15 10 15 (2)序列編號NO: 791資料： (i) 序列特性： (A) 長度：6胺基酸 (B) 形式：胺基酸

(C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 791

Gly Gly Gly Ser Gly Gly 1 5 (2)序列編號NO: 792資料： (i) 序列特性： (A) 長度：7胺基酸

(B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO·. 792

Gly Gly Gly Ser Gly Gly Gly 1 5 (2)序列編號NO: 793資料： (i)序列特性： (A)長度：10胺基酸 O:\92\92747.DOC -534- 200413407 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 793

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 1 5 10 (2)序列編號NO: 794資料： (i) 序列特性： (A) 長度：13胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 794

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 1 5 10 (2)序列編號NO: 795資料： (i) 序列特性： (A) 長度：15胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構.線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 795

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 15 10 15 (2)序列編號NO: 796資料： O:\92\92747.DOC 535 200413407 (i) 序列特性： (A) 長度：21胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 796

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 1 5 10 15

Gly Gly Gly Ser Gly 20 (2)序列編號NO: 797資料： (i)序列特性： (A) 長度：21胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (Π)分子類型：無 (xi)序列描述：序列編號NO: 797

Pro Pro Pro Trp Ser Pro Arg Pro Leu Gly Ala Thr Ala Pro Thr Ala 1 5 10 15

Gly Gin Pro Pro Leu 20 (2)序列編號NO: 798資料： (i)序列特性： (A) 長度：15胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (Π)分子類型：無 O:\92\92747.DOC 536- 200413407 (xi)序列描述：序列編號NO: 798

Pro Pro Pro Trp Ser Pro Arg Pro Leu Gly Ala Thr Ala Pro Thr 1 5 10 15 (2)序列編號NO: 799資料： (i) 序列特性： (A) 長度.16胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無籲 (xi)序列描述：序列編號NO: 799

Val Glu Thr Val Phe His Arg Val Ser Gin Asp Gly Leu Leu Thr Ser 1 5 10 15 (2)序列編號NO: 800資料： (i) 序列特性： (A) 長度：36胺基酸 (B) 形式：胺基酸 (C) 股數：單

(D) 拓撲結構：線形 I (ii) 分子類型：無 (xi)序列描述：序列編號NO: 800

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Glu Gly Gly Gly 1 5 10 15

Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser 20 25 30

Gly Gly Gly Ser 35 (2)序列編號NO: 801資料： (i)序列特性： (A) 長度：24胺基酸 (B) 形式：胺基酸 O:\92\92747.DOC -537- 200413407 (c)股數：單 (D)拓撲結構：線形 (ii)分子類型：無 (xi)序列描述：序列編號NO: 801 lie Ser Glu Pro Ser Gly Pro He Ser Thr He Asn Pro Ser Pro Pro 1 5 10 15

Ser Lys Glu Ser His Lys Ser Pro 20 (2)序列編號NO·· 802資料： (i) 序列特性： (A) 長度：28胺基酸籲 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 802 lie Glu Gly Arg He Ser Glu Pro Ser Fly Pro lie Ser Thr lie Asn 1 5 10 15

Pro Ser Pro Pro Ser Lys Glu Ser His Lys Ser Pro 20 25 (2)序列編號NO: 803資料： (i) 序列特性： · (A) 長度· 112胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 803

Ala Asn Cys Ser He Met He Asp Glu lie lie His His Leu Lys Arg 1 5 10 15

Pro Pro Ala Pro Leu Leu Asp Pro Asn Asn Leu Asn Ala Glu Asp Val 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Glu Ser Phe O:\92\92747.DOC -538- 200413407 35 40 45

Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110 (2)序列編號NO: 804資料： (i) 序列特性： (A) 長度：112胺基酸 (B) 形式：胺基酸

(C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 804

Ala Asn Cys Ser He Met He Asp Glu lie lie His His Leu Lys Arg 1 5 10 15

Pro Pro Asn Pro Leu Leu Asp Pro Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Thr Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys His Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie lie Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu

85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110 (2)序列編號NO: 805資料： (i) 序列特性： (A) 長度：112胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 805 O:\92\92747.DOC -539- 200413407

Ala Asn Cys Ser lie Met lie Asp Glu lie lie His His Leu Lys Val 15 10 15

Pro Pro Ala Pro Leu Leu Asp Ser Asn Asn Leu Asn Ser Glu Asp Met 20 25 30

Asp lie Leu Met Glu Arg Asn Leu Arg Leu Pro Asn Leu Leu Ala Phe 35 40 45

Val Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie 50 55 60

Leu Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser 65 70 75 80

Arg His Pro lie lie He Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu 85 90 95

Lys Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110 (2)序列編號NO: 806資料： (i) 序列特性：

(A) 長度：111胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線形 (ii) 分子類型：無 (xi)序列描述：序列編號NO: 806

Asn Cys Ser lie Met lie Asp Glu lie He His His Leu Lys Arg Pro 15 10 15

Arg Ala Val Lys Asn Leu Glu Asn Ala Ser Gly lie Glu Ala lie Leu 50 55 60

Arg Asn Leu Gin Pro Cys Leu Pro Ser Ala Thr Ala Ala Pro Ser Arg 65 70 75 80

His Pro lie He He Lys Ala Gly Asp Trp Gin Glu Phe Arg Glu Lys 85 90 95

Leu Thr Phe Tyr Leu Val Thr Leu Glu Gin Ala Gin Glu Gin Gin 100 105 110 (2)序列編號NO: 807資料： (i)序列特性： (A) 長度：33鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 O:\92\92747.DOC 540- 33 200413407 (xi)序列描述：序列編號NO: 807

CTGACCATGG CNACCCAGGA CTGCTCCTTC CAA (2)序列編號NO: 808資料： (i)序列特性： (A) 長度· 3 2驗基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形

(xi)序列描述：序列編號NO: 808 ACTGAAGCTT AGGGCTGACA CTGCAGCTCC AG (2)序列編號NO: 809資料： (i)序列特性： (A) 長度：32鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形

(xi)序列描述：序列編號NO: 809 ACTGAAGCTT ACAGGGTTGA GGAGTCGGGC TG (2)序列編號NO: 810資料： (i)序列特性： (A) 長度：46驗基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 810

GACTGCCATG GCNACyCAGG AYTGYTCyTT YCAACACAGC CCCATC 46

O:\92\92747.DOC -541- 200413407 (2)序列編號NO: 811資料： (i)序列特性： (A) 長度：46驗基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形

(xi)序列描述：序列編號NO: 811 GACTGCCATG GCNACyCAGG AYTGYTCyTT TCAACACAGC (2)序列編號NO: 812資料： (i)序列特性： (A) 長度：22驗基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 812

TGTCCAAACT CATCAATGTA TC (2)序列編號NO·· 813資料： (i)序列特性： (A) 長度：38鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 813

CATGGCCATG GCCGACGAGG AGCTCTGCGG GGGCCTCT (2)序列編號NO: 814資料： (i)序列特性： CCCATC 46

O:\92\92747.DOC -542 200413407 (A) 長度：36驗基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 814 GCTAGAAGCT TACTGCAGGT TGGAGGCCAC GGTGAC (2)序列編號NO: 815資料： (i)序列特性： (A) 長度：38鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 815 GATGGCCATG GCCTCCAAGA TGCAAGGCTT GCTGGAGC (2)序列編號NO: 816資料： (i)序列特性： (A) 長度：36驗基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 816 GCTAGAAGCT TACCCAGCGA CAGTCTTGAG CCGCTC (2)序列編號NO: 817資料： (i)序列特性： (A) 長度：36鹼基對 (B) 形式：核酸 36

38

36 O:\92\92747.DOC 543- 36 200413407 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 817

CATGGCCATG GCCCCCCCCA GCTGTCTTCG CTTCGT (2)序列編號NO: 81 8資料： (i)序列特性： (A) 長度：37鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形

(xi)序列描述：序列編號NO: 818 GCTAGAAGCT TAGGGCTGAA AGGCACATTT GGTGACA (2)序列編號NO: 819資料： (i)序列特性： (A) 長度· 4 2驗基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形

(xi)序列描述：序列編號NO: 819 CCCTGTCTGG CGGCAACGGC ACCCAGGACT GCTCCTTCCA AC (2)序列編號NO: 820資料： (i)序列特性： (A) 長度· 4 8驗基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 37 42

O:\92\92747.DOC -544- 200413407 (xi)序列描述：序列編號NO: 820 GCGGTAACGG CAGTGGAGGT AATGGCACCC AGGACTGCTC CTTCCAAC 48 (2)序列編號NO: 821資料： (i)序列特性： (A) 長度：57鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形

(xi)序列描述：序列編號NO: 821 ACGGCAGTGG TGGCAATGGG AGCGGCGGAA ATGGAACCCA GGACTGCTCC TTCCAAC 57 (2)序列編號NO: 822資料： (i)序列特性： (A) 長度：38鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形

(xi)序列描述：序列編號NO: 822 GTGCCGTTGC CGCCAGACAG GGTTGAGGAG TCGGGCTG 38 (2)序列編號NO: 823資料： (0序列特性： (A) 長度：48鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 823 ATTACCTCCA CTGCCGTTAC CGCCTGACAG GGTTGAGGAG TCGGGCTG 48 O:\92\92747.DOC -545- 200413407 (2)序列編號NO·· 824資料： (i)序列特性： (A) 長度· 5 4驗基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形

GCTG

(xi)序列描述：序列編號NO: 824 GCTCCCATTG CCACCACTGC CGTTACCTCC AGACAGOUT GAGGAGTCGG (2)序列編號NO: 825資料： (i)序列特性： (A) 長度：60鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形

TCCTTCCACC

(xi)序列描述：序列編號NO·. 825 GATGAGGATC CGGTGGCAAT GGGAGCGGCG GAAATGGAAC CCAGGACTGC (2)序列編號NO·. 826資料： (i)序列特性： (A) 長度：45鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形

(xi)序列描述：序列編號NO: 826 GATGACGGAT CCGmCCTC CAGACAGGGT TGAGGAGTCG GGCTG (2)序列編號NO: 827資料： (i)序列特性： O:\92\92747.DOC 546- 200413407 (A) 長度：46驗基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 827

GATGACGGAT CCGGAGGTAA TGGCACCCAG GACTGCTCCT (2)序列編號NO: 828資料： (i)序列特性： (A) 長度：29鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 828

GACTGCCATG GCCGACGAGG AGCTCTGCG (2)序列編號NO: 829資料： (i)序列特性： (A) 長度：28鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 829

GACTCAAGCT TACTGCAGGT TGGAGGCC (2)序列編號NO: 830資料： (i)序列特性__ (A) 長度· 3 9驗基對 (B) 形式：核酸 TCCAAC 46

O:\92\92747.DOC -547- 200413407 (c)股數：單 (D)拓撲結構·線形 (xi)序列描述：序列編號NO.· 830

GACTCGGGAT CCGGAGGTTC TGGCACCCAG GACTGCTCC (2)序列編號NO: 831資料： (i)序列特性： (A) 長度_ 41驗基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形

(xi)序列描述：序列編號NO: 831 GACTGGGATC CGGTGGCAGT GGGAGCGGCG GATCTGGAAC (2)序列編號NO: 832資料： (i)序列特性： (A) 長度：39鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO·. 832

GACTTGGGAT CCACTACCTC CAGACAGGGT TGAGGAGTC (2)序列編號NO·· 833資料： (i)序列特性： (A) 長度：39鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 O:\92\92747.DOC -548- 200413407 (xi)序列描述：序列編號NO: 833 ACTGACGGAT CCACCGCCCA GGGTTGAGGA GTCGGGCTG 39 (2)序列編號NO: 834資料： (i)序列特性： (A) 長度：51鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 834 ACTGACGGAT CCACCTCCTG ACCCACCGCC CAGGGTTGAG GAGTCGGGCT G 51 (2)序列編號NO: 835資料： (i)序列特性： (A) 長度：63鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 835 ACTGACGGAT CCACCTCCTG ACCCACCTCC TGACCCACCG CCCAGGGTTG AGGAGTCGGG 60 CTG 63 (2)序列編號NO: 836資料： ⑴序列特性： (A) 長度：28驗基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 836 28

ACGTAAAGCT TACAGGGTTG AGGAGTCG O:\92\92747.DOC -549- 200413407 (2)序列編號N〇：837資料： (i)序列特性： (A) 長度· 40驗基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 837 GTCAGTGGAT CCGGAGGTAC CCAGGACTGC TCCTTCCAAC 40

(2)序列編號NO: 838資料： (i)序列特性： (A) 長度：43鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 838 GTCAGTGGAT CCGGAGGTGG CACCCAGGAC TGCTCCTTCC AAC 43

(2)序列編號NO: 839資料： (i)序列特性： (A) 長度：60鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 839 TCAGTGGATC CGGAGGTGGC TCAGGGGGAG GTAGTGGTAC CCAGGACTGC TCCTTCCAAC 60 (2)序列編號NO: 840資料： (i)序列特性： O:\92\92747.DOC 550- 200413407 (A) 長度：27鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 840

TAGTCCATGG CCACCCAGGA CTGCTCC (2)序列編號NO: 841資料： (i)序列特性： (A) 長度· 3 1驗基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 841

GCATTACGTA GGGCTGACAC TGCAGCTCCA G (2)序列編號NO: 842資料： (i)序列特性： (A) 長度：31驗基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 842

GCATTACGTA CAGGGTTGAG GAGTCGGGCT G (2)序列編號NO: 843資料： (i)序列特性： (A) 長度：37鹼基對 (B) 形式：核酸 O:\92\92747.DOC -551 37 200413407 (c)股數：單 (D)拓撲結構：線形 (xi)序列描述：序列編號NO.· 843

GTCAGACCAT GGCCGATTAC CCAGTCACCG TGGCCTC (2)序列編號NO: 844資料： (i)序列特性： (A) 長度：39鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形

(xi)序列描述：序列編號NO: 844 TCTGACAAGC TTATTGAAGC AGGTAGTCAG ACAGCTCAC (2)序列編號NO: 845資料： (i)序列特性： (A) 長度：37鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形

(xi)序列描述：序列編號NO: 845 GTCAGCCCAT GGCCGCCTCC AACCTGCAGG ACGAGGA (2)序列編號NO: 846資料： (i)序列特性： (A) 長度：37鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 39 37

O:\92\92747.DOC -552- 200413407 (xi)序列描述：序列編號NO: 846

TCTGACAAGC TTACACGGTG ACTGGGTAAC mkkGC (2)序列編號NO: 847資料： (i)序列特性： (A) 長度：38驗基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形

(xi)序列描述：序列編號NO: 847 GTCAGACCAT GGCCGTCGCT GGGTCCAAGA TGCAAGGC (2)序列編號NO: 848資料： (i)序列特性： (A )長度· 3 7驗基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 848

TCTGACAAGC TTAAGTCTTG AGCCGCTCCA TCCAGCG (2)序列編號NO: 849資料： (i)序列特性： (A) 長度：38鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 849

GTCAGACCAT GGCCCGCTTC GTCCAGACCA ACATCTCC O:\92\92747.DOC -553- 200413407 (2)序列編號NO: 850資料： (i)序列特性： (A) 長度：36鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形

(xi)序列描述：序列編號NO: 850 TCTGACAAGC TTAAAGACAG CTGGGGGGGG GCTGAA (2)序列編號NO: 851資料： (i)序列特性： (A) 長度：38鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形

(xi)序列描述：序列編號NO: 851 GTCAGACCAT GGCCACCAAC ATCTCCCGCC TCCTGCAG (2)序列編號NO: 852資料： (i)序列特性： (A) 長度：37鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形

(xi)序列描述：序列編號NO: 852 CTCGACAAGC TTACTGGACG AAGCGAAGAC AGCTGGG (2)序列編號NO: 853資料： (i)序列特性： 36

38

O:\92\92747.DOC -554- 37 200413407 (A) 長度：33鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 853 GATCACATGT CTACAAATCA AGATCTGCCT GTG (2)序列編號NO: 854資料： (i)序列特性： (A) 長度：30驗基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 854 GATCGAATTC GTTGTCTTGG ATGAAAGGGA (2)序列編號NO: 855資料： (i)序列特性： (A) 長度：32鹼基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 855 ACTTGAATTC ATCATCCTGG GCCTGTTCGG GC (2)序列編號NO: 856資料： (i)序列特性： (A) 長度：30鹼基對 (B) 形式：核酸 33

30

32 O:\92\92747.DOC 555- 30 200413407 (c)股數：單 (D)拓撲結構：線形 (xi)序列描述：序列編號NO: 856

ACTCAAGCTT AGAAGCTCCC CAGCGCCTCC (2)序列編號NO: 857資料： (i)序列特性： (A) 長度· 6 4驗基對 (B) 形式：核酸 (C) 股數：單 (D) 拓撲結構：線形 (xi)序列描述：序列編號NO: 857 64

GGATCCACCA TGAGCCGCCT GCCCGTCCTG CTCCTGCTCC AACTCCTGGT CCGCCCCGCC 60 ATGG (2)序列編號NO: 858資料： (i) 序列特性： (A) 長度：174胺基酸 (B) 形式：胺基酸

(C) 股數··未知 (D) 拓撲結構：未知 (ii) 分子類型：蛋白質 (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：1 (C) 其他資料：/note = 第 1 位之 Xaa係 Thr、Ser、Arg、 Tyr或 Gly ;，’ (xi)特徵： (A)名稱/關键字：經修飾位點 O:\92\92747.DOC -556- 200413407 (B) 位置：2 (C) 其他資料：/note = ”第2位之Xaa係Pro或Leu ; (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：3 (C) 其他資料：/note = π第3位之Xaa係Leu、Arg、Tyr或 Ser ;，丨 (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：13 ® (C) 其他資料：/note = ”第 13位之 Xaa 係 Phe、Ser、His、

Thr或 Pro ; π (xi)特徵： (A) 名稱/關键字：經修飾位點 (B) 位置：16 (C) 其他資料：/note = π 第 16位之 Xaa係 Lys、Pro、Ser、

Thr或 His ; ’， (xi)特徵： (A) 名稱/關鍵字：經修飾位點籲 (B) 位置：17 (C) 其他資料·· /note = 第 17 位之 Xaa 係 Cys、Ser、Gly、

Ala、lie、Tyr或 Arg ; (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：18 (C) 其他資料：/note = f’第 18位之 Xaa 係 Leu、Thr、Pro、

His、lie或 Cys ; ’， (xi)特徵： O:\92\92747.DOC -557- 200413407 (A) 名稱/關鍵字：經修飾位點 (B) 位置：22 (C) 其他資料：/note = 第 22 位之 Xaa 係 Arg、Tyr、Ser、

Thr或 Ala ;，， (xi)特徵： (A) 名稱/關键字：經修飾位點 (B) 位置：24 (C) 其他資料：/note = ”第24位之Xaa係lie、Pro、Tyr或 Leu ; (xi)特徵：春 (A) 名稱/關鍵字：經修飾位點 (B) 位置：27 (C) 其他資料：/note = 第27位之Xaa係Asp或Gly ; (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：30 (C) 其他資料：/note = ff 第 30位之 Xaa係 Ala、lie、Leu或 Gly ;，， (xi)特徵： φ (Α)名稱/關鍵字：經修飾位點 (B) 位置：34 (C) 其他資料：/note = 第3 4位之Xaa係Lys或Ser ; ” (xi)特徵： (A) 名稱/關键字：經修飾位點 (B) 位置：36 (C) 其他資料：/note = 第3 6位之Xaa係Cys或Ser ; (xi)特徵： (A)名稱/關键字：經修飾位點 O:\92\92747.DOC -558- 200413407 (B) 位置：42 (C) 其他資料：/note = ”第42位之Xaa係Cys或Ser ; (xi)特徵： (A) 名稱/關键字：經修飾位點 (B) 位置：43 (C) 其他資料：/note 二 π 第 43 位之 Xaa 係 His、Thr、Gly、

Val、Lys、Trp、Ala、Arg、Cys或 Leu ; (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：44 ® (C) 其他資料：/note = ff 第 44位之 Xaa係 Pro、Gly、Arg、

Asp、Val、Ala、His、Trp、Gin或 Thr ; π (xi)特徵： (A) 名稱/關键字：經修飾位點 (B) 位置：46 (C) 其他資料：/note = 第 46 位之 Xaa 係 Glu、Arg、Phe、

Arg、lie或 Ala ;丨， (xi)特徵： (A) 名稱/關键字：經修飾位點 _ (B) 位置：47 (C) 其他資料：/note = 第47位之Xaa係Leu或Thr ; (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：49 (C) 其他資料：/note = 第 49位之 Xaa係 Leu、Phe、Arg或 Ser ;丨， (xi)特徵： (A)名稱/關键字：經修飾位點 O:\92\92747.DOC -559- 200413407 (B) 位置：50 (C) 其他資料：/note = ’’第 50 位之 Xaa 係 Leu、lie、His、

Pro 或 Tyr ; (xi)特徵： (A) 名稱/關键字：經修飾位點 (B) 位置：54 (C) 其他資料·· /note = 第54位之Xaa係Leu或His ; π (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：64 春 (C) 其他資料：/note = ”第64位之Xaa係Cys或Ser ; (xi)特徵： (A) 名稱/關键字：經修飾位點 (B) 位置：67 (C) 其他資料：/note = ”第67位之Xaa係Gin、Lys、Leu或 Cys ； f, (xi)特徵： (A) 名稱/關键字：經修飾位點 (B) 位置：70 # (C) 其他資料：/note = ” 第 70 位之 Xaa 係 Gin、Pro、Leu、

Arg或 Ser ; (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：74 (C) 其他資料：/note = 第74位之Xaa係Cys或Ser ; (xi)特徵： (A) 名稱/關键字：經修飾位點 (B) 位置：104 O:\92\92747.DOC 560 200413407 (C)其他資料：/note = ’’第1 04位之Xaa係Asp、Gly或 Val ;，’ (xi)特徵： (A)名稱/關鍵字：經修飾位點 (B) 位置：108 (C) 其他資料：/note = π 第 1 08 位之 Xaa 係 Leu、Ala、 Va卜 Arg、Trp、Gin或 Gly ;丨， (xi)特徵： (A)名稱/關键字：經修飾位點

(B) 位置：115 (C) 其他資料：/note = 第 115位之 Xaa係 Thr、His、Leu 或Ala ;丨， (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：120 (C) 其他資料：/note = fl 第 120位之 Xaa係 Gin、Arg、Phe 或 Thr ; (xi)特徵： (A) 名稱/關鍵字：經修飾位點 _ (B) 位置：123 (C) 其他資料：/note = 第 123 位之 Xaa 係 Glu、Arg、Phe 或 Thr ; π (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：144 (C) 其他資料：/note = 第 144 位之 Xaa 係 Phe、His、

Arg 、 Pro 、 Leu 、 Gin或 Glu ; ” (xi)特徵： O:\92\92747.DOC 561- 200413407 (A) 名稱/關键字：經修飾位點 (B) 位置：146 (C) 其他資料·· /note = ”第146位之Xaa係Arg或Gin ; (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：147 (C) 其他資料：/note = ”第147位之Xaa係Arg或Gin ; (xi)特徵： (A) 名稱/關键字：經修飾位點 (B) 位置：156 (C) 其他資料·· /note = 第 156位之 Xaa 係 His、Gly 或 Ser ; π (xi)特徵： (A) 名稱/關键字：經修飾位點 (B) 位置：159 (C) 其他資料：/note = ” 第 159 位之 Xaa 係 Ser、Afg、 Thr、Tyr、Val或 Gly ;，， (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：162 (C) 其他資料·· /note = π第 162 位之 Xaa 係 Glu、Leu、Gly 或 Trp ; (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：163 (C) 其他資料：/note = 第 163 位之 Xaa 係 Val、Gly、Arg 或 Ala ;，’ (xi)特徵： O:\92\92747.DOC -562- 200413407 (A) 名稱/關键字：經修飾位點 (B) 位置·· 169 (C) 其他資料·· /note ="第 169 位之 Xaa 係 Arg、Ser、 Leu、Arg或 Cys ; (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：170

(C) 其他資料：/note = π第170位之Xaa係His、Arg或 Ser ； M (xi)序列描述：序列編號NO: 858

Xaa Xaa Xaa G;u Pro Ala Ser Ser Leu Pro Gin Ser Xaa Leu Leu Xaa

Xaa Xaa Glu Gin Val Xaa Lys Xaa Gin Gly Xaa Gly Ala Xaa Leu Gin 20 25 30

Glu Xaa Leu Xaa Ala Thr Tyr Lys Leu Xaa Xaa Xaa Glu Xaa Xaa Val 35 40 45

Xaa Xaa Gly His Ser Xaa Gly lie Pro Trp Ala Pro Leu Ser Ser Xaa 50 55 60

Pro Ser Xaa Ala Leu Xaa Leu Ala Gly Xaa Leu Ser Gin Leu His Ser 65 70 75 80

Gly Leu Phe Leu Tyr Gin Gly Leu Leu Gin Ala Leu Glu Gly lie Ser 85 90 95

Pro Glu Leu Gly Pro Thr Leu Xaa Thr Leu Gin Xaa Asp Val Ala Asp 100 105 110

Phe Ala Xaa Thr lie Trp Gin Gin Met Glu Xaa Xaa Gly Met Ala Pro 115 120 125

Ala Leu Gin Pro Thr Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Xaa 130 135 140

Gin Xaa Xaa Ala Gly Gly Val Leu Val Ala Ser Xaa Leu Gin Xaa Phe 145 150 155 160

Leu Xaa Xaa Ser Tyr Arg Val Leu Xaa Xaa Leu Ala Gin Pro (2)序列編號NO: 859資料： (i)序列特性： O:\92\92747.DOC -563- 200413407 (A) 長度：133胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線性 (ii)分子類型：蛋白質 (xi)特徵： (A) 名稱/關键字：經修飾位點 (B) 位置：17 (C) 其他資料：/note = ”第 17 位之 Xaa 係 Ser、Lys、Gly、 Asp、Met、Gin或 Arg ; π (xi)特徵： (A) 名稱/關键字：經修飾位點 (B) 位置：18 (C) 其他資料：/note = 第 1 8位之 Xaa係 Asn、His、Leu、 lie、Phe、Arg或 Gin ;，’ (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：19

(C) 其他資料·· /note = 第 19位之 Xaa係 Met、Phe、lie、 Arg、Gly、Ala或 Cys ; M (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：20 (C) 其他資料：/note = 第 20 位之 Xaa 係 lie、Cys、Gin、 Glu、Arg、Pro或 Ala ; π (xi)特徵： (A) 名稱/關键字：經修飾位點 (B) 位置：21 O:\92\92747.DOC -564 200413407 (C)其他資料：/note = π 第 21位之 Xaa係 Asp、Phe、Lys、

Arg、Ala、Gly、Glu、Gin、Asn、Thr、Ser或 Val ;丨’ (xi)特徵： (A) 名稱/關键字：經修飾位點 (B) 位置：22 (C) 其他資料：/note 二’’第 22 位之 Xaa 係 Glu、Trp、Pro、

Ser、Ala、His、Asp、Asn、Gin、Leu、Val或 Gly ; (xi)特徵： (A) 名稱/關键字：經修飾位點 (B) 位置：23 鲁 (C) 其他資料：/note = 第 23 位之 Xaa 係 lie、Val、Ala、

Gly、Trp、Lys、Phe、Leu、Ser或 Arg ; (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：24 (C) 其他資料：/note = 第 24位之 Xaa係 lie、Gly、Val、

Arg、Ser、Phe或 Leu ; π (xi)特徵： (A) 名稱/關鍵字：經修飾位點籲 (B) 位置：25 (C) 其他資料：/note = 第 25位之 Xaa 係 Thr、His、Gly、

Gin、Arg、Pro或 Ala ; (xi)特徵： (A) 名稱/關键字：經修飾位點 (B) 位置：26 (C) 其他資料：/note = 第 26位之 Xaa係 His、Thr、Phe、

Gly、Arg、Ala或 Trp ; π (xi)特徵： O:\92\92747.DOC -565- 200413407 (A) 名稱/關键字：經修飾位點 (B) 位置：27 (C) 其他資料：/note = π 第 27 位之 Xaa 係 Leu、Gly、Arg、

Thr、Ser或 Ala ;丨’ (xi)特徵： (A) 名稱/關键字：經修飾位點 (B) 位置：28 (C) 其他資料：/note = π 第 28位之 Xaa係 Lys、Arg、Leu、

Gin、Gly、Pro、Val或 Trp ;丨’ (xi)特徵：鲁 (A) 名稱/關鍵字：經修飾位點 (B) 位置：29 (C) 其他資料：/note = ff 第 29位之 Xaa係 Gin、Asn、Leu、

Pro、Arg或 Val ; π (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：30 (C) 其他資料：/note = 第 30位之 Xaa 係 Pro、His、Thr、

Gly、Asp、Gin、Ser、Leu或 Lys ·，’’ ❿ (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：31 (C) 其他資料：/note = ” 第 3 1 位之 Xaa係 Pro、Asp、Gly、

Ala、Arg、Leu或 Gin ; (xi)特徵： (A) 名稱/關键字：經修飾位點 (B) 位置：32 (C) 其他資料：/note = 第 32位之 Xaa係 Leu、Val、Arg、 O:\92\92747.DOC -566- 200413407

Gin、Asn、Gly、Ala或 Glu ;" (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：33 (C) 其他資料：/note = π 第 33位之 Xaa係 Pro、Leu、Gin、 Ala、Thr或 Glu ;丨， (xi)特徵： (A) 名稱/關键字：經修飾位點 (B) 位置：34 (C) 其他資料：/note = ”第34位之 Xaa係 Leu、Val、Gly、 Ser、Lys、Glu、Gin、Thr、Arg、Ala、Phe、lie 或 Met ;丨， (xi)特徵： (A) 名稱/關键字：經修飾位點 (B) 位置：35 (C) 其他資料·· /note = 第 3 5位之 Xaa係 Leu、Ala、Gly、 Asn、Pro、Gin或 Val ; ” (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：36 (C) 其他資料：/note = 第 36位之 Xaa係 Asp、Leu或 Val ; (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：37 (C) 其他資料：/note = π 第 37位之 Xaa係 Phe、Ser、Pro、 Trp或 lie ; ’， (xi)特徵： O:\92\92747.DOC -567- 200413407 (A) 名稱/關键字：經修飾位點 (B) 位置：38 (C) 其他資料：/note = ”第38位之Xaa係Asn或Ala ; ff (xi)特徵： (A) 名稱/關键字：經修飾位點 (B) 位置：40 (C) 其他資料：/note = π 第 40位之 Xaa係 Leu、Trp或 Arg ; ff (xi)特徵： (A) 名稱/關键字：經修飾位點 (B) 位置：41 (C) 其他資料：/note = M 第 41位之 Xaa係 Asn、Cys、Arg、 Leu、His、Met或 Pro ; (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：42 (C) 其他資料：/note = ’’ 第 42位之 Xaa係 Gly、Asp、Ser、 Cys、Asn、Lys、Thr、Leu、Val、Glu、Phe、Tyr、 lie、Met或 Ala ;，， (xi)特徵： (A) 名稱/關键字：經修飾位點 (B) 位置：43 (C) 其他資料：/note = 第 43 位之 Xaa .Glu、Asn、Tyr、 Leu、Phe、Asp、Ala、Cys、Gin、Arg、Thr、Gly 或 Ser ;，， (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：44 O:\92\92747.DOC -568- 200413407 (C)其他資料：/note = ”第 44 位之 Xaa 係 Asp、Ser、Leu、 Arg、Lys、Thr、Met、Trp、Glu、Asn、Gin、Ala 或 Pro ； ff (xi)特徵： (A.)名稱/關键字：經修飾位點 (B) 位置：45 (C) 其他資料：/note = 第 45 位之 Xaa 係 Gin、Pro、Phe、 Val、Met、Leu、Thr、Lys、Trp、Asp、Asn、Arg、 Ser、Ala、lie、Glu或 His ;，， (xi)特徵： (A) 名稱/關键字：經修飾位點 (B) 位置：46 (C) 其他資料：/note = 第 46 位之 Xaa .Asp、Phe、Ser、 Thr、Cys、Glu、Asn、Gin、Lys、His、Ala、Tyr、 lie、Val或 Gly ;，， (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：47 (C) 其他資料：/note = π 第 47位之 Xaa係 lie、Gly、Val、 Ser、Arg、Pro或 His ; (xi)特徵： (A) 名稱/關键字：經修飾位點 (B) 位置：48 (C) 其他資料：/note = π 第 48位之 Xaa係 Leu、Ser、Cys、 Arg、lie、His、Phe、Glu、Lys、Thr、Ala、Met、Val 或 Asn ;，， (xi)特徵： (A)名稱/關键字：經修飾位點 O:\92\92747.DOC -569 200413407 (B) 位置：49 (C) 其他資料·· /note = ’’ 第 49位之 Xaa係 Met、Arg、Ala、

Gly、Pro、Asn、His或 Asp ; (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：50 (C) 其他資料：/note = ”第 50位之 Xaa 係 Glu、Leu、Thr、

Asp、Tyr、Lys、Asn、Ser、Ala、lie、Vail、His、

Phe、Met或 Gin ; ’， (xi)特徵：鲁 (A) 名稱/關鍵字：經修飾位點 (B) 位置：51 (C) 其他資料：/note = ·’ 第 5 1 位之 Xaa係 Asn、Arg、Met、

Pro、Ser、Thr或 His ;，， (xi)特徵： (A) 名稱/關键字：經修飾位點 (B) 位置：55 (C) 其他資料：/note = 第 52 位之 Xaa 係 Asn、His、Arg、

Leu、Gly、Ser或 Thr ; ❿ (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：53 (C) 其他資料·· /note = 第 53位之 Xaa 係 Leu、Thr、Ala、

Gly、Glu、Pro、Lys、Ser或 Met ; (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：54 (C) 其他資料：/note = 第 54位之 Xaa係 Arg、Asp、lie、 O:\92\92747.DOC -570- 200413407

Ser、Val、Thr、Gin、Asn、Lys、His、Ala或 Leu ; (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：55 (C) 其他資料·· /note = 第 55 位之 Xaa 係 Arg、Thi*、Val、 Ser、Leu或 Gly ;丨’ (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：56 (C) 其他資料：/note = π 第 56位之 Xaa係 Pro、Gly、Cys、 Ser、Gin、Glu、Arg、His、Thr、Ala、Tyr、Phe、 Leu、Val或 Lys ; (xi)特徵： (A) 名稱/關键字：經修飾位點 (B) 位置：57 (C) 其他資料：/note = 第57位之Xaa係Asn或Gly ; (xi)特徵： (A) 名稱/關键字：經修飾位點 (B) 位置：58 (C) 其他資料：/note = π 第 58位之 Xaa係 Leu、Ser、Asp、 Arg、Gin、Val或 Cys ; (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：59 (C) 其他資料：/note = ” 第 59 位之 Xaa 係 Gluu、Tyr、 His、Leu、Pro或 Arg ; π (xi)特徵： (A)名稱/關键字：經修飾位點 O:\92\92747.DOC -571 200413407 (B) 位置·· 60 (C) 其他資料：/note = ’’第 60 位之 Xaa 係 Ala、Ser、Pro、

Tyr、Asn或 Thr ; ’’ (xi)特徵： (A) 名稱/關键字：經修飾位點 (B) 位置：61 (C) 其他資料：/note = 第 61位之 Xaa 係 Phe、Asn、Glu、

Pro、Lys、Arg或 Ser ;丨’ (xi)特徵： (A) 名稱/關鍵字：經修飾位點 _ (B) 位置：62 (C) 其他資料：/note = π 第 62位之 Xaa係 Asn、His、Val、

Arg、Pro、Thr、Asp或 lie ; (xi)特徵： (A) 名稱/關键字：經修飾位點 (B) 位置：63 (C) 其他資料：/note = π 第 63 位之 Xaa係 Arg、Tyr、Trp、

Lys、Ser、His、Pro或 Val ;，， (xi)特徵： φ (A) 名稱/關键字：經修飾位點 (B) 位置：64 (C) 其他資料：/note = ?丨第 64 位之 Xaa 係 Ala、Asn、Pro、

Ser或 Lys ;，， (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：65 (C) 其他資料：/note = 第 65 位之 Xaa 係 Val、Thr、Pro、

His、Leu、Phe或 Ser ; O:\92\92747.DOC -572- 200413407 (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：66 (C) 其他資料：/note =，'第 66位之 Xaa係 Lys、lie、Arg、 Va卜 Asn、Glu或 Ser ; (xi)特徵： (A) 名稱/關键字：經修飾位點 (B) 位置：67 (C) 其他資料·· /note = 第 67 位之 Xaa 係 Ser、Ala、Phe、 Va卜 Gly、Asn、lie、Pro或 His ; ’， (xi)特徵： (A) 名稱/關键字：經修飾位點 (B) 位置：68 (C) 其他資料：/note = 第 68 位之 Xaa 係 Leu、Val、Trp、 Ser、lie、Phe、Thr或 His ; ” (xi)特徵： (A) 名稱/關键字：經修飾位點 (B) 位置：69 (C) 其他資料：/note = 第 69 位之 Xaa 係 Gin、Ala、Pro、 Thr、Glu、Arg、Trp、Gly 或 Leu ; (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：70 (C) 其他資料：/note = 第 70 位之 Xaa 係 Asn、Leu、Val、 Trp、Pro或 Ala ; ’， (xi)特徵： (A) 名稱/關键字：經修飾位點 (B) 位置：71 O:\92\92747.DOC -573- 200413407 (C)其他資料：/note = ’▼第 71位之 Xaa係 Ala、Met、Leu、

Pro、Arg、Glu、Thr、Gin、Trp 或 Asn ; (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：72 (C) 其他資料：/note = 第 72 位之 Xaa 係 Ser、Glu、Met、

Ala、His、Asn、Arg或 Asp ; (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：73 # (C) 其他資料：/note = π 第 73位之 Xaa係 Ala、Glu、Asp、

Leu、Ser、Gly、Thr或 Arg ; (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：74 (C) 其他資料·· /note = 第 74 位之 Xaa 係 lie、Met、Thr、

Pro、Arg、Gly、Ala ; ’丨 (xi)特徵： (A) 名稱/關鍵字：經修飾位點籲 (B) 位置：75 (C) 其他資料：/note = 第 75位之 Xaa 係 Glu、Lys、Gly、

Asp、Pro、Trp、Arg、Ser、Gin或 Leu ; ” (xi)特徵： (A) 名稱/關键字：經修飾位點 (B) 位置：76 (C) 其他資料：/note = 第 76 位之 Xaa 係 Ser、Val、Ala、

Asn、Trp、Glu、Pro、Gly 或 Asp ; (xi)特徵： O:\92\92747.DOC 574- 200413407 (A) 名稱/關键字：經修飾位點 (B) 位置：77 (C) 其他資料：/note = 第 77位之 Xaa係 lie、Ser、Arg、

Thr或 Leu ;丨， (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：78 (C) 其他資料：/note = 第78位之Xaa係1^11、八比、8€1·、

Glu、Phe、Gly 或 Arg ;丨’ (xi)特徵：鲁 (A) 名稱/關鍵字：經修飾位點 (B) 位置：79 (C) 其他資料：/note = 第 79位之 Xaa係 Lys、Thr、Asn、

Met、Arg、lie、Gly 或 Asp ;丨’ (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：80 (C) 其他資料：/note = f’第 80 位之 Xaa 係 Asn、Trp、Val、

Gly、Thr、Leu、Glu或 Arg ; · (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：81 (C) 其他資料：/note = 第 81位之 Xaa 係 Leu、Gin、Gly、

Ala、Trp、Arg、Val或 Lys ; (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：82 (C) 其他資料·· /note = 第 82 位之 Xaa 係 Leu、Gin、Lys、 O:\92\92747.DOC •575- 200413407

Trp、Arg、Aas、Glu、Asn、His、Thr、Ser、Ala、

Tyr、Phe、lie、Met或 Val ;，， (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：83 (C) 其他資料：/note = ”第 83 位之 Xaa 係 Pro、Ala、Thr、

Trp、Arg或 Met ; (xi)特徵： (A) 名稱/關键字：經修飾位點 (B) 位置：84 鲁 (C) 其他資料：/note = ” 第 84位之 Xaa係 Cys、Glu、Gly、

Arg、Met或 Val ;，， (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：85 (C) 其他資料：/note = 第 85位之 Xaa係 Leu、Asn、Val或 Gin ;，， (xi)特徵： (A) 名稱/關键字：經修飾位點籲 (B) 位置：86 (C) 其他資料：/note = 第 86位之 Xaa係 Pro、Cys、Arg、

Ala或 Lys ;丨’ (xi)特徵： (A) 名稱/關键字：經修飾位點 (B) 位置：87 (C) 其他資料：/note = π第87位之Xaa係Leu、Ser、Trp或 Gly ;，’ (xi)特徵： O:\92\92747.DOC -576- 200413407 (A) 名稱/關键字：經修飾位點 (B) 位置：88 (C) 其他資料：/note = π 第 88位之 Xaa係 Ala、Lys、Arg、

Val 或 Trp ;丨， (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：89 (C) 其他資料：/note = 第 89位之 Xaa係 Thr、Asp、Cys、

Ley、Val、Glu、His、Asn或 Ser ; (xi)特徵：鲁 (A) 名稱/關鍵字：經修飾位點 (B) 位置：90 (C) 其他資料：/note = 第 90位之 Xaa係 Ala、Pro、Ser、

Thr、Gly、Asp、lie或 Met ; ’， (xi)特徵： (A) 名稱/關键字：經修飾位點 (B) 位置：91 (C) 其他資料：/note = π 第 91 位之 Xaa係 Ala、Pro、Ser、

Thr、Phe、Leu、Asp或 His ;丨’ · (xi)特徵： (A) 名稱/關键字：經修飾位點 (B) 位置：92 (C) 其他資料·· /note = π 第 92位之 Xaa係 Pro、Phe、Arg、

Ser、Lys、His、Ala、Gly、lie或 Leu ; (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：93 (C) 其他資料：/note = 第 93位之 Xaa 係 Thr、Asp、Ser、 O:\92\92747.DOC 577- 200413407

Asn、Pro、Ala、Leu或 Arg ; (xi)特徵： (A) 名稱/關键字：經修飾位點 (B) 位置：94 (C) 其他資料：/note = 第 94 位之 Xaa 係 Arg、lie、Ser、 Glu、Leu、Val、Gin、Lys、His、Ala或 Pro ;丨’ (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：95 (C) 其他資料：/note = 第 95 位之 Xaa 係 His、Gin、Pro、 Arg、Val、Leu、Gly、Thr、Asn、Lys、Ser、Ala、 Trp、Phe、lie或 Tyr ; ’’ (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：96 (C) 其他資料：/note = 第 96 位之 Xaa 係 Pro、Lys、Tyr、 Gly、lie或 Thr ; (xi)特徵： (A) 名稱/關键字：經修飾位點 (B) 位置：97 (C) 其他資料：/note = 第 97位之 Xaa係 lie、Val、Lys、 Ala或 Asn ;，， (xi)特徵： (A) 名稱/關键字：經修飾位點 (B) 位置：98 (C) 其他資料：/note = π 第 98位之 Xaa係 His、lie、Asn、 Leu、Asp、Ala、Thr、Glu、Gin、Ser、Phe、Met、 Val、Lys、Arg、Tyr或 Pro ; O:\92\92747.DOC -578- 200413407 (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：99 (C) 其他資料：/n〇te = π 第 99位之 Xaa係 lie、Leu、Arg、

Asp、Va卜 Pro、Gin、Gly、Ser、Phe或 His ; (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：100 (C) 其他資料：/n〇te =，，第 1〇〇位之 xaa 係 Lys、Tyr、

Leu、His、Arg、lie、Ser、Gin或 Pro ; η Φ (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：101 (C) 其他資料·· /n〇te =，’ 第 ιοί 位之 xaa 係 Asp、Pro、

Met、Lys、His、Thr、Val、Tyr、Glu、Asn、Ser、

Ala、Gly、lie、Leu或 Gin ;，， (xi)特徵： (A) 名稱/關鍵字··經修飾位點 (B) 位置：102 _ (C) 其他資料：/note = ” 第 102 位之 Xaa 係 Gly、Leu、

Glu、Lys、Ser、Tyr或 Pro ;" (xi)特徵： (A )名稱/關鍵字：經修飾位點 (B) 位置：103 (C) 其他資料：/note = ”第103位之Xaa係Asp或Ser ; ” (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：104

O:\92\92747.DOC -579- 200413407 (C)其他資料：/note = ’’ 第 1 04 位之 Xaa 係 Trp、Val、 Cys、Tyr、Thr、Met、Pro、Leu、Gin、Lys、Ala、Phe 或 Gly ;，， (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：105 (C) 其他資料：/note = 第 105 位之 Xaa 係 Asn、Pro、 Ala、Phe、Ser、Trp、Gin、Tyr、Leu、Lys、lie、Asp 或His ;丨’ (xi)特徵： (A) 名稱/關键字：經修飾位點 (B) 位置：106 (C) 其他資料：/note = 第 106 位之 Xaa 係 Glu、Ser、 Ala、Lys、Thr、lie、Gly或 Pro ; (xi)特徵： (A) 名稱/關键字：經修飾位點 (B) 位置：108 (C) 其他資料：/note = 第 108 位之 Xaa 係 Arg、Lys、 Asp、Leu、Thr、lie、Gin、His、Ser、Ala或 Pro ; (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：109 (C) 其他資料：/note = 第 109 位之 Xaa 係 Arg、Thr、 Pro、Glu、Tyr、Leu、Ser或 Gly ; π (xi)特徵： (A) 名稱/關键字：經修飾位點 (B) 位置：110 (C) 其他資料：/note = 第 110位之 Xaa係 Lys、Ala、Asn、 O:\92\92747.DOC -580- 200413407

Thr、Leu、Arg、Gin、His、Glu、Ser或 Trp ; n (xi)特徵： (A) 名稱/關键字：經修飾位點 (B) 位置：111 (C) 其他資料：/note = M 第 111 位之 Xaa係 Leu、lie、Arg、 Asp或 Met ; (xi)特徵： (A) 名稱/關键字：經修飾位點 (B) 位置：1 12 (C) 其他資料：/n〇te =，，第 112 位之 Xaa 係 Thr、Val、 Gin、Tyr、Glu、His、Ser或 Phe ; π (xi)特徵： (A) 名稱/關键字：經修飾位點 (B) 位置：113 (C) 其他資料：/note =，，第 113 位之 Xaa 係 Phe、Ser、 Cys、His、Gly、Trp、Tyr、Asp、Lys、Leu、lie、Val 或 Asn ; ” (xi)特徵： (A) 名稱/關键字：經修飾位點 (B) 位置：114 (C) 其他資料：/note = ”第U4位之xaa係Tyr、Cys、 His、Ser、Trp、Arg或 Leu ; ” (xi)特徵： (A) 名稱/關鍵字··經修飾位點 (B) 位置：11 5 (C) 其他資料：/n〇te = ” 第 1 i 5 位之 xaa 係 Leu、Asn、 Val、Pro、Arg、Ala、His、Thr、Trp或 Met ;，f (xi)特徵：

O:\92\92747.DOC 581- 200413407 (A) 名稱/關鍵字：經修飾位點 (B) 位置：116 (C) 其他資料：/note = 第 116 位之 Xaa 係 Lys、Leu、 Pro、Thr、Met、Asp、Val、Glu、Arg、Trp、Ser、 Asn、His、Ala、Tyr、Phe、Gin或 lie ; n (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：117 (C) 其他資料：/note = π 第 117 位之 Xaa 係 Thr、Ser、 Asn、lie、Trp、Lys或 Pro ; (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：118 (C) 其他資料：/note = π 第 118 位之 Xaa 係 Leu、Ser、 Pro、Ala、Glu、Cys、Asp或 Tyr ; (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：119 (C) 其他資料：/note =，’ 第 119 位之 Xaa 係 Glu、Ser、 Lys、Pro、Leu、Thr、Tyr或 Arg ;丨丨 (B) 位置：120 (C) 其他資料：/note =丨’第120位之Xaa係Asn、Ala、 Pro、Leu、His、Val或 Gin ; (xi)特徵： (A) 名稱/關键字：經修飾位點 (B) 位置：121 (C) 其他資料：/note = 第 121 位之 Xaa 係 Ala、Ser、lie、 Asn、Pro、Lys、Asp或 Gly ; O:\92\92747.DOC -582- 200413407 (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：122 (C) 其他資料：/note = ”第122位之Xaa係Gin、Ser Trp、Arg、Phe、Pro、His、lie、Tyr或 Cys ; π (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：123 (C) 其他資料·· /note = ”第123位之Xaa係Ala、 Glu、His、Ser、Pro、Tyr或 Leu ; (xi)序列描述：序列編號NO: 859

Ala Pro Met Thr Gin Thr Thr Ser Leu Lys Thr Ser Trp Val Asn Cys 15 10 15

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 20 25 30

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 35 40 45

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 50 55 60

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 65 70 75 80

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 85 90 95

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Phe Xaa Xaa Xaa Xaa Xaa 100 105 110

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gin Gin Thr Thr Leu 115 120 125

Ser Leu Ala lie Phe 130 (2)序列編號NO: 860資料： (i)序列特性： (A) 長度：153胺基酸 (B) 形式：胺基酸

Met、

O:\92\92747.DOC -583- 200413407 (c)股數：未知 (D)拓撲結構：未知 (ii)分子類型：蛋白質 (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：112 (C) 其他資料：/note = ’’第112位之Xaa係經刪除或為 Leu、Ala、Val、lie、Pro、Phe、Trp或 Met ; (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：113 (C) 其他資料：/n〇te = ”第113位之Xaa係經删除或為 Pro、Phe、Ala、Va卜 Leu、lie、Trp或 Met ;，， (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：114 (C) 其他資料：/n〇te = ”第114位之Xaa係經刪除或為 Pro、Phe、Ala、Va卜 Leu、lie、Trp或 Met ; (xi)特徵： (A) 名稱/關鍵字：經修飾位點 (B) 位置：115 (C) 其他資料：/note = ”第11 5位之Xaa係經刪除或為 Gin、Gly、Ser、Thr、Tyr或 Asn ; ’， (xi)序列描述：序列編號NO: 860

Ser Pro Ala Pro Pro Ala Cys Asp Leu Arg Val Leu Ser Lys Leu Leu 1 5 10 15

Arg Asp Ser His Val Leu His Ser Arg Leu Ser Gin Cys Pro Glu Val 2〇 25 30

His Pro Leu Pro Thr Pro Val Leu Leu Pro Ala Val Asp Phe Ser Leu 35 40 45 O:\92\92747.DOC -584 200413407

Gly Glu Trp Lys Thr Gin Met Glu Glu Thr Lys Ala Gin Asp lie Leu 50 55 60

Gly Ala Val Thr Leu Leu Leu Glu Gly Val Met Ala Ala Arg Gly Gin 65 70 75 80

Leu Gly Pro Thr Cys Leu Ser Ser Leu Leu Gly Gin Leu Ser Gly Gin 85 90 95

Val Arg Leu Leu Leu Gly Ala Leu Gin Ser Leu Leu Gly Thr Gin Xaa 100 105 110

Xaa Xaa Xaa Gly Arg Thr Thr Ala His Lys Asp Pro Asn Ala lie Phe 115 120 125

Leu Ser Phe Gin His Leu Leu Arg Gly Lys Val Arg Phe Leu Met Leu 130 135 140

Val Glu Gly Ser Thr Leu Cys Val Arg 145 150 (2)序列編號NO·. 861資料： (i)序列特性： (A) 長度：1胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線性 (Π)分子類型：蛋白質 (xi)特徵： (A) 名稱/關键字：蛋白質 _ (B) 位置：1 (C) 其他資料：/note = π其中 X = (glyglyglySer)n 且其中 η 係整數π (xi)序列描述：序列編號NO: 861

Xaa 1 (2)序列編號NO: 862資料： (i)序列特性： O:\92\92747.DOC -585- 200413407 (A) 長度：1胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線性 (ii)分子類型：蛋白質 (xi)特徵： (A) 名稱/關鍵字·肤 (B) 位置：1 (C) 其他資料：/note = 其中 X = (glyglyglyglySer)n 且其中η係整數” (xi)序列描述：序列編號NO: 862

Xaa 1 (2)序列編號NO: 863資料： (i) 序列特性： (A) 長度：1胺基酸 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線性 (ii) 分子類型：蛋白質 (xi)特徵： (A) 名稱/關键字：蛋白質 (B) 位置：1 (C) 其他資料·· /note = 其中 X = (glyglyglyglyglySer)n 且其中η係整數” (xi)序列描述：序列編號NO: 863

Xaa O:\92\92747.DOC -586- 200413407 (2)序列編號NO: 864資料： (i) 序列特性： (A) 長度：1胺基酸、 (B) 形式：胺基酸 (C) 股數：單 (D) 拓撲結構：線性 (ii) 分子類型··蛋白質 (xi)特徵： (A) 名稱/關鍵字：蛋白質 (B) 位置：1 (C) 其他資料：/note = ”其中χ = (gly n Ser)n且其中祕整數’’ ^ (xi)序列描述·序列編號N〇：864

Xaa (2)序列編號NO: 865資料： (i)序列特性： (A) 長度：1胺基酸 (B) 形式：胺基酸 (c)股數：單 (D) 拓撲結構··線性 (H)分子類型：蛋白質 (χί)特徵： (A) 名稱/關鍵字··蛋白質 (B) 位置：1 ()/、他貝料· /n〇te =,,其中 X = 且其中 η係 0：\92\92747 -587 200413407 整數’’ (xi)序列描述：序列編號NO: 865

Xaa

O:\92\92747.DOC -588-

Claims

200413407 拾、申請專利範園： 1 · 一種用於治療患有造血疾病之病患之醫藥組合物，其係 I '1 轉殖於該病患，包含經培養之細胞，其係得自下列步騾之方法， (a) 自該病患體内取出造血細胞； (b) 在含有造血蛋白之培養基中培養該等經分離之造血細胞；及 (c) 收集該等經培養之細胞；其中，該造血蛋白為下式之胺基酸序列：、R2-L1-R1、R1-R2、或 R2-Ri 其中I係一種多肽，其為下式之經修飾flt-3配位體胺基酸序列：， ThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArg 10 20 GluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAsp 30 40 GluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeu 50 60

LysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHis 70 80 PheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsn 90 100 工 leSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThr 110 120 ArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeu 130 序列編號N〇：466 其中N-端係直接或經由一連接子（L2)而與C-端連結，該連接子可連接N-端及C-端，且具有分別位於下列胺基酸之新C-及N-端； 28 - 29 42 - 43 93 - 94 O:\92\92747.DOC 200413407 29 - 30 64 - 65 94 -95 30 - 31 65 - 66 95 -96 31 - 32 66 - 67 96 -97 32 - 33 86 - 87 97 - 98 34 - 35 87 - 88 98 -99 36 - 37 88 - 89 99 -100 37 - 38 89 - 90 100-101 38 - 39 90 - 91 101-102 39 - 40 91 - 92 102-103 40 - 41 92 - 93 41 - 42 9 其中R2係一種因子，其選自： flt-3、 G-CSF及GM-CSF ;或 R2係一種多肽，其為下式之經修飾人類G-CSF胺基酸序列 1 Xaa Xaa Xaa G; u Pro Ala Ser Ser Leu 10 Pro Gin Ser Xaa Leu Leu Xaa Xaa Xaa 20 Glu Gin Val Xaa Lys Xaa Gin Gly Xaa Gly Ala 30 Xaa Leu Gin Glu Xaa Leu Xaa Ala Thr Tyr 40 Lys Leu Xaa Xaa Xaa Glu Xaa Xaa Val 50 Xaa Xaa Gly His Ser Xaa Gly lie Pro Trp Ala 60 Pro Leu Ser Ser Xaa Pro Ser Xaa Ala Leu 70 Xaa Leu Ala Gly Xaa Leu Ser Gin Leu 80 His Ser Gly Leu Phe Leu Tyr Gin Gly Leu Leu 90 Gin Ala Leu Glu Gly lie Ser Pro Glu Leu 100 Gly Pro Thr Leu Xaa Thr Leu .Gin Xaa 110 Asp Val Ala Asp Phe Ala Xaa Thr lie Trp Gin 120 Gin Met Glu Xaa Xaa Gly Met Ala Pro Ala 130 Leu Gin Pro Thr Gin Gly Ala .Met Pro 140 Ala Phe Ala Ser Ala Xaa Gin Xaa Xaa Ala 150 160

O:\92\92747.DOC 200413407 Gly Gly Val Leu Val Ala Ser Xaa Leu Gin Xaa Phe Leu Xaa Xaa 170 Ser Tyr Arg Val Leu Xaa Xaa Leu Ala Gin Pro 序歹l]編號 NO: 858 其中第 1 位之 Xaa係 Thr、Ser、Arg、Tyr或 Gly ; 第2位之Xaa係Pro或Leu ; 第 3位之 Xaa係 Leu、Arg、Tyr或 Ser ; 第 13 位之 Xaa 係 Phe、Ser、His、Thr 或 Pro ; 第 16 位之 Xaa 係 Lys、Pro、Ser、Thr 或 His ; 第 17位之 Xaa係 Cys、Ser、Gly、Ala、lie、Tyr 或 Arg ; 第 18位之 Xaa係 Leu、Thr、Pro、His、lie或 Cys ; 第 22位之 Xaa係 Arg、Tyr、Ser、Thr或 Ala ; 第 24 位之 Xaa 係 lie、Pro、Tyr 或 Leu ; 第27位之Xaa係Asp或Gly ; 第 3 0位之 Xaa係 Ala、lie、Leu或 Gly ; 第34位之Xaa係Lys或Ser ; 第36位之Xaa係Cys或Ser ; 第42位之Xaa係Cys或Ser ; 第 43 位之 Xaa係 His、Thr、Gly、Val、Lys、Trp、Ala、 Arg、Cys或 Leu ·，第 44位之 Xaa係 Pro、Gly、Arg、Asp、Val、Ala、His、 Trp、Gin或 Thr ; 第 46位之 Xaa係 Glu、Arg、Phe、Arg、lie或 Ala ; 第47位之Xaa係Leu或Thr ; 第 49位之 Xaa係 Leu、Phe、Arg或 Ser ; O:\92\92747.DOC 200413407 第 5 0位之 Xaa係 Leu、lie、His、Pro或 Tyr ; 第54位之Xaa係Leu或His ; 第64位之Xaa係Cys或Ser ; 第67位之又&&係0111、1^8、1^11或€73; 第 70位之 Xaa係 Gin、Pro、Leu、Arg或 Ser ; 第74位之Xaa係Cys或Ser ; 第 104位之 Xaa係 Asp、Gly 或 Val ; 第 108位之 Xaa係 Leu、Ala、Val、Arg、Trp、Gin或 Gly ; 第 115位之 Xaa係 Thr、His、Leu或 Ala ; 第 120位之 Xaa係 Gin、Gly、Arg、Lys或 His ; 第 123 位之 Xaa 係 Glu、Arg、Phe 或 Thr ; 第 144位之 Xaa係 Phe、His、Arg、Pro ' Leu、Gin或 Glu ; 第146位之Xaa係Arg或Gin ; 第147位之Xaa係Arg或Gin ; 第 156 位之 Xaa 係 His、Gly 或 Ser ; 第 159位之 Xaa係 Ser、Arg、Thr、Tyr、Val或 Gly ; 第 162 位之 Xaa 係 Glu、Leu、Gly 或 Trp ; 第 163位之 Xaa係 Va卜 Gly、Arg或 Ala ; 第 1 69位之 Xaa係 Arg、Ser、Leu、Arg或 Cys ; 第 170 位之 Xaa 係 His、Arg 或 Ser ; 其中選擇性自N-端起之1-11胺基酸及自C-端起之1-5胺基酸可自該經修飾之人類G-CSF胺基酸序列刪除；其中N-端係直接或經由一連接子（L2)而與C-端連結，該連接子可連接N-端及C-端，且具有分別位於下列胺基酸 O:\92\92747.DOC -4 - 之新C-及N-端； 38 - 39 62 -63 123 - 39 - 40 63 -64 124 - 40 - 41 64 -65 125 - 41 - 42 65 -66 126 - 42 - 43 66 -67 128 - 43 - 44 67 -68 128 - 45 - 46 68 -69 129 - 48 - 49 69 -70 130 - 49 - 50 70 -71 131 - 52 - 53 71 -72 132 - 53 - 54 91 -92 133 - 54 - 55 92 -93 134 - 55 - 56 93 -94 135 - 56 - 57 94 -95 136 - 57 - 58 95 -96 137 - 58 - 59 96 -97 138 - 59 - 60 97 -98 139 - 60 - 61 98 -99 140 - 61 - 62 99 -100 141 - 或 142 - 200413407 其中該連接子（L2)係選自： Ser ; Asn ; O:\92\92747.DOC 200413407 Gly ； Thr ； GlySer ； AlaAla: GlySerGly ； GlyGlyGly ； GlyAsnGly ;

GlyAlaGly ； GlyThrGly ； AlaSerAla ; AlaAlaAla ; GlyGlyGlySer序列編號NO:778; 01><}1><}1>^心1}<}1}<}1}^1'序列編號>10:779; 86力1><}1>^旧1}<}1}^1：序列編號>10:781;

0111?1^01}^\311^^1:序列編號^0:782; 01\1?1^01)<}1)^811]^1;序列編號1<[0:783; 011^1^01丫01>^811〇1}^1}^\5111^1:序列編號1^0:784; 01><}1}^“5卩]^1八1&01>^序列編號：^0:785; 861<}15<}1}^\811<}17序列編號1^0:786; SerGlyGlyAsnGlySerGlyGlyAsnGlySerGlyGlyAsnGly 序列編號N〇:788 ; 8沉〇1><}1}^幻1}^沿1><}1>^沿1}^沿1}<}1>^沿17序列編號1^〇:790; O:\92\92747.DOC -6- 200413407 01><}1}<}1}^€力1}<}以序列編號>^0:791; 〇1}<}1)<}1}^0心1}<}1}<}1)^序列編號：^〇:792; GlyGlyGlySerGlyGlyGlySerGlyGly序列編號NO:793; 01><}1}<}1}^6心1><}1}<}1}^6沿15<}1}<}1>^沿以序列編號：^0:794; GlyGlyGlySerGlyGlyGlySeIGlyGlyGlySerGlyGlyGly序列編號NO:795; GlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGly 序列編號NO : 796 ; ProProProTrpSerProArgProLeuGlyAlaThrAlaProThrAlaGlyGlnProProLeu 序列編號NO: 797 ; ProProProTrpSerProArgProLeuGlyAlaThrAlaProThr 序列編號n〇:798 ;及 \/^101111111：\^1?1161£3八吗\^186心11^3?01>1^111^1111^^]：序列編號；^0:799; 其中1^係可連接1及112之連接子，其為長度介於1至500 個胺基酸，具有含Gly，Asn，Ser，Thr或Ala之胺基酸序列之任何排列順序之多肽；且該造血蛋白之前端可選擇性毗鄰（甲硫胺酸-1)、（丙胺酸-1) 或（甲硫胺酸_2，丙胺酸，。 2 · —種用於治療患有造血疾病之病患之醫藥組合物，其係轉殖於該病患，包含經培養之細胞，其係得自下列步驟之方法： (a) 自該病患體内取出造血細胞； (b) 將造血細胞與其他細胞分離； (c) 在含有造血蛋白之培養基中培養該等經分離之造血細胞；及 (d) 收集該等經培養之細胞； O:\92\92747.DOC -7- 200413407 其中，該造血蛋白為下式之胺基酸序列： R^-Li-R〗、、R^_R2、或 R2-Ri 其中&係一種多肽，其為下式之經修飾flt-3配位體胺基酸序列： ThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArg 10 20 GluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAsp 30 40 GluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeu 50 60

LysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHis 70 80 PheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsn 90 100 工leSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThr 110 120 ArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeu 130 序列編號NO: 466 其中N-端係直接或經由一連接子（L2)而與C-端連結，該連接子可連接N-端及C-端，且具有分別位於下列胺基酸之新C-及N-端； 28 -29 42 - 43 93-94 29 -30 64 - 65 94-95 30 -31 65 - 66 95-96 31 -32 66 - 67 96-97 32 -33 86 - 87 97-98 34 -35 87 - 88 98-99 36 -37 88 - 89 99-100 37 -38 89 - 90 100-101 38 -39 90 - 91 101-102

O:\92\92747.DOC 200413407 39 - 40 91 - 92 102 - 103 40 - 41 92 - 93 41-42 ；其中R2係一種因子，其選自：flt-3、G-CSF及GM-CSF ;或 R2係一種多肽，其為下式之經修飾人類G-CSF胺基酸序列： 1 10 Xaa Xaa Xaa G;u Pro Ala Ser Ser Leu Pro Gin Ser Xaa 20 Leu Leu Xaa Xaa Xaa Glu Gin Val Xaa Lys Xaa Gin Gly Xaa Gly 30 40

Ala Xaa Leu Gin Glu Xaa Leu Xaa Ala Thr Tyr Lys Leu Xaa Xaa 50 Xaa Glu Xaa Xaa Val Xaa Xaa Gly His Ser Xaa Gly lie Pro Trp 60 70 Ala Pro Leu Ser Ser Xaa Pro Ser Xaa Ala Leu Xaa Leu Ala Gly 80 Xaa Leu Ser Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu 90 100 Leu Gin Ala Leu Glu Gly lie Ser Pro Glu Leu Gly Pro Thr Leu 110 Xaa Thr Leu Gin Xaa Asp Val Ala Asp Phe Ala Xaa Thr lie Trp 120 130 Gin Gin Met Glu Xaa Xaa Gly Met Ala Pro Ala Leu Gin Pro Thr 140 Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Xaa Gin Xaa Xaa Ala 150 160 Gly Gly Val Leu Val Ala Ser Xaa Leu Gin Xaa Phe Leu Xaa Xaa 170 Ser Tyr Arg Val Leu Xaa Xaa Leu Ala Gin Pro 序歹,J 編號 NO: 858 其中第 1 位之 Xaa係 Thr、Ser、Arg、Tyr或 Gly ; 第^位之Xaa係Pro或Leu ; 第 3位之 Xaa係 Leu、Arg、Tyr或 Ser ; 第 13位之 Xaa係 Phe、Ser、His、Thr或 Pro ; 第 16位之 Xaa係 Lys、Pro、Ser、Thr或 His ; O:\92\92747.DOC -9- 200413407 第 1 7位之 Xaa係 Cys、Ser、Gly、Ala、lie、Tyr或 Arg ; 第 18位之 Xaa係 Leu、Thr、Pro、His、lie或 Cys ; 第 22位之 Xaa係 Arg、Tyr、Ser、Thr或 Ala ; 第 24位之 Xaa係 lie、Pro、Tyr或 Leu ; 第27位之Xaa係Asp或Gly ; 第 3 0位之 Xaa係 Ala、lie、Leu或 Gly ; 第34位之Xaa係Lys或Ser ; 第36位之Xaa係Cys或Ser ; 第42位之Xaa係Cys或Ser ; 第 43 位之 Xaa係 His、Thr、Gly、Va卜 Lys、Trp、Ala、 Arg、Cys或 Leu ; 第 44位之 Xaa係 Pro、Gly、Arg、Asp、Val、Ala、His、 Trp、Gin或 Thr ; 第46位之乂&&係0111、人巧、？1^、八巧、116或八1&; 第47位之Xaa係Leu或Thr ; 第 49位之 Xaa係 Leu、Phe、Arg或 Ser ; 第 5 0位之 Xaa係 Leu、lie、His、Pro或 Tyr ·，第54位之Xaa係Leu或His ; 第64位之Xaa係Cys或Ser ; 第 67位之 Xaa係 Gin、Lys、Leu或 Cys ·，第 70位之 Xaa係 Gin、Pro、Leu、Arg或 Ser ; 第74位之Xaa係Cys或Ser ; 第 104位之 Xaa係 Asp、Gly 或 Val ; 第 108位之 Xaa係 Leu、Ala、Val、Arg、Trp、Gin或 Gly ; O:\92\92747.DOC -10· 200413407 第 115位之 Xaa係 Thr、His、Leu或 Ala ; 第 120位之 Xaa係 Gin、Gly、Arg、Lys 或 His ; 第 123位之 Xaa係 Glu、Arg、Phe或 Thr ; 第 144位之 Xaa係 Phe、His、Arg、Pro、Leu、Gin或 Glu ; 第146位之Xaa係Arg或Gin ; 第147位之Xaa係Arg或Gin ; 第 156 位之 Xaa 係 His、Gly 或 Ser ; 第 159位之 Xaa係 Ser、Arg、Thr、Tyr、Val或 Gly ; 第 1 62位之 Xaa係 Glu、Leu、Gly 或 Trp ; 第 163位之 Xaa係 Val、Gly、Arg或 Ala ; 第 169位之 Xaa係 Arg、Ser、Leu、Arg或 Cys ; 第 170 位之 Xaa 係 His、Arg 或 Ser ; 其中選擇性自N-端起之1-11胺基酸及自C-端起之1-5胺基酸可自該經修飾之人類G-CSF胺基酸序列刪除；其中N-端係直接或經由一連接子（L2)而與C-端連結，該連接子可連接N-端及C-端，且具有分別位於下列胺基酸之新C-及N-端； 123-124 124 - 125 125-126 126 - 127 128- 129 128 - 129 129- 130 38 - 39 62 - 63 39 - 40 63 - 64 40 - 41 64 - 65 41 - 42 65 - 66 42 - 43 66 - 67 43 - 44 67 - 68 45 - 46 68 - 69 O:\92\92747.DOC -11 - 48 -49 69 -70 130 - 49 -50 70 -71 131 - 52 -53 71 -72 132 - 53 -54 91 -92 133 - 54 -55 92 -93 134 - 55 -56 93 -94 135 - 56 -57 94 -95 136 - 57 -58 95 -96 137 - 58 -59 96 -97 138 - 59 -60 97 -98 139 - 60 -61 98 -99 140 - 61 -62 99 -100 141 -或 142 - 200413407 其中該連接子（l2)係選自： Ser ; Asn ; Gly ； Thr ； GlySer ； AlaAla: GlySerGly ； GlyGlyGly ； GlyAsnGly ; GlyAlaGly ; O:\92\92747.DOC -12- 200413407 GlyThrGly ； AlaSerAla ； AlaAlaAla ； GlyGlyGlySeΓ序列編號NO:778; 0以01><}1}^沿1}<}1)<}1}^1：序列編號>^0:779; 01)01}<：1}^仙}<}1>^1}^沿1}<}1}<}1}^]：序列編號：^0:780; 8。&1><}1}^6力15<}1}^61*序列編號]\10:781;

0111?1^01)^311]\^1:序列編號1^0:782; 0111?1^01}<}1}^^111^1:序列編號>^0:783; 011^1^01}<}1}^^11〇1)<}1}^^11\1^序列編號：^0:784; 01)<}1}^6认3卩]^^八13〇1)^序列編號1<[〇:785; SeΓGlyGlyAsnGly序列編號NO:786; SerGlyGlyAsnGlySerGlyGlyAsnGly序列編號NO:787; SerGlyGlyAsnGlySerGlyGlyAsnGlySerGlyGlyAsnGly 序列編號NO:788 ; SerGlyGlySerGlySerGlyGlySerGly 序列編號]^0:789;

86心13^}13^心坆8€心1)<}1>^订〇15^1<}1><}1}^沿17序列編號1\[〇:790; GlyGlyGlySerGlyGly序列編號Nσ·791; 01><}1><}1>^6沿1)<}1}<}1}^心1}<}17序列編號1^0:793; 〇1}<}1)<}1}^£沿1}<}1}<31}^心1}<}1}<}17801<}以序列編號>^〇:794; 01)<}1}^1>^沿1}^1}^1}^101}<}1)^1>^沿1}^1>^1)^序列編號^[〇:795; GlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGly 序列編號NO :796 ; ProProProTrpSerProArgProLeuGlyAlaThrAlaProThrAlaGlyGlnProProLeu O:\92\92747.DOC -13 - 200413407 序列編號NO: 797 ; 卩1：〇?1：〇?1'〇1^86$1*〇^^?1'〇1^11〇1}^^11^八以?1<〇1111<序列編號;^〇:798;及 \^10111丁111*\^1?1161^八巧\^186^11^\5卩01}^1^111^111!1^61*序列編號;^〇:799; 其中。係可連接1^及112之連接子，其為長度介於1至500 個胺基酸，具有含Gly，Asn，Ser，Thr或Ala之胺基酸序列之任何排列順序之多肽；且該造血蛋白之前端可選擇性姻:鄰（甲硫胺酸-1)、（丙胺酸-1) 或（甲硫胺酸_2，丙胺酸4)。 3 · —種用於人類基因治療之醫藥組合物，其係經轉殖至該病患，包含經轉導之細胞，其係得自下列步驟之方法； (a) 自該病患體内取出造血細胞； (b) 將造血細胞與其他細胞分離； (c) 在含有造血蛋白之培養基中培養該等經分離之造血細胞； (d) 將DNA引入該等經培養之細胞中；及 (e) 收集該等經轉導之細胞；其中，該造血蛋白為下式之胺基酸序列： R1 - L1 - R2、R2 - L1 - R1、R1 - R2、或 * R1 其中K係一種多肽，其為下式之經修飾flt-3配位體胺基酸序列： ThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArg 10 20 GluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAsp 30 40 'GluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeu 50 60 LysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHis O:\92\92747.DOC -14- 200413407 70 80 PheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsn 90 100 工leSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThr 110 120 ArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeu 130 序列編號NO: 466 其中N-端係直接或經由一連接子（L2)而與C-端連結，該連接子可連接N-端及C-端，且: 具有S 新C-及N-端， 28 -29 42 -43 93 - 94 29 -30 64 -65 94 - 95 30 -31 65 -66 95 - 96 31 -32 66 -67 96 - 97 32 -33 86 -87 4 97 - 98 34 -35 87 -88 98 - 99 36 -37 88 -89 99 - 100 37 -38 89 -90 100 -101 38 -39 90 -91 101 -102 39 -40 91 -92 102 -103 40 -41 92 -93 41 -42

其中R2係一種因子，其選自：flt-3、G-CSF及GM-CSF ;或 R2係一種多肽，其為下式之經修飾人類G-CSF胺基酸序列： 1 10 Xaa Xaa Xaa G;u Pro Ala Ser Ser Leu Pro Gin Ser Xaa 20 Leu Leu Xaa Xaa Xaa Glu Gin Val Xaa Lys Xaa Gin Gly Xaa Gly 30 40 Ala Xaa Leu Gin Glu Xaa Leu Xaa Ala Thr Tyr Lys Leu Xaa Xaa O:\92\92747.DOC -15- 50 50200413407 Xaa Glu Xaa Xaa Val Xaa Xaa Gly His Ser Xaa Gly lie Pro Trp 60 70 Ala Pro Leu Ser Ser Xaa Pro Ser Xaa Ala Leu Xaa Leu Ala Gly 80 Xaa Leu Ser Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu 90 100 Leu Gin Ala Leu Glu Gly lie Ser Pro Glu Leu Gly Pro Thr Leu 110 Xaa Thr Leu Gin Xaa Asp Val Ala Asp Phe Ala Xaa Thr lie Trp 120 130 Gin Gin Met Glu Xaa Xaa Gly Met Ala Pro Ala Leu Gin Pro Thr 140 Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Xaa Gin Xaa Xaa Ala 150 160 Gly Gly Val Leu Val Ala Ser Xaa Leu Gin Xaa Phe Leu Xaa Xaa 170 Ser Tyr Arg Val Leu Xaa Xaa Leu Ala Gin Pr〇序歹i]編號 NO: 858 其中第 1位之 Xaa係 Thr、Ser、Arg、Tyr或 Gly ; 第2位之Xaa係Pro或Leu ; 第 3位之 Xaa係 Leu、Arg、Tyr或 Ser ; 第 13 位之 Xaa 係 Phe、Ser、His、Thr 或 Pro ; 第 16位之 Xaa係 Lys、Pro、Ser、Thr或 His ; 第 17位之 Xaa係 Cys、Ser、Gly、Ala、lie、Tyr 或 Arg ; 第 18位之 Xaa係 Leu、Thr、Pro、His、lie或 Cys ; 第 22位之 Xaa係 Arg、Tyr、Ser、Thr或 Ala ; 第 24位之 Xaa係 lie、Pro、Tyr 或 Leu ; 第27位之Xaa係Asp或Gly ; 第 3 0位之 Xaa係 Ala、lie、Leu或 Gly ; 第34位之Xaa係Lys或Ser ; 第3 6位之Xaa係Cys或Ser ; 第42位之Xaa係Cys或Ser ; O:\92\92747.DOC - 16- 200413407 第 43 位之 Xaa係 His、Thr、Gly、Va卜 Lys、Trp、Ala、 Arg、Cys或 Leu ; 第 44位之 Xaa係 Pro、Gly、Arg、Asp、Val、Ala、His、 Trp、Gin或 Thr ; 第46位之又&&係0111、八巧、？1^、八巧、11€或八13; 第47位之Xaa係Leu或Thr ; 第 49位之 Xaa係 Leu、Phe、Arg或 Ser ;

第 50位之 Xaa係 Leu、lie、His、Pro或 Tyr ; 第54位之Xaa係Leu或His ; 第64位之Xaa係Cys或Ser ; 第 67位之 Xaa係 Gin、Lys、Leu或 Cys ; 第 70位之 Xaa係 Gin、Pro、Leu、Arg或 Ser ; 第74位之Xaa係Cys或Ser ; 第 104位之 Xaa係 Asp、Gly 或 Val ;

第 108位之 Xaa係 Leu、Ala、Val、Arg、Trp、Gin或 Gly ; 第 11 5位之 Xaa係 Thr、His、Leu或 Ala ; 第 120位之 Xaa係 Gin、Gly、Arg、Lys或 His ; 第 123位之 Xaa係 Glu、Arg、Phe或 Thr ; 第 144位之 Xaa係 Phe、His、Arg、Pro、Leu、Gin或 Glu ; 第146位之Xaa係Arg或Gin ; 第147位之Xaa係Arg或Gin ; 第 156 位之 Xaa 係 His、Gly 或 Ser ; 第 159位之 Xaa係 Ser、Arg、Thr、Tyr、Val或 Gly ; 第 162 位之 Xaa 係 Glu、Leu、Gly 或 Trp ; O:\92\92747.DOC -17- 200413407 第 163位之 Xaa係 Va卜 Gly、Arg或 Ala ; 第 1 69位之 Xaa係 Arg、Ser、Leu、Arg或 Cys ; 第 170位之 Xaa係 His、Arg或 Ser ; 其中選擇性自N-端起之l-ii胺基酸及自C_端起之i_5胺基酸可自該經修飾之人類G—CSF胺基酸序列刪除；其中N-端係直接或經由一連接子（Lj而與c_端連結，該連接子可連接N-端及c-端，且之新C-及N-端； 38 -39 62 63 123 - 39 - 40 63 - 64 124 - 40 -41 64 - 65 125 - 41 -42 65 _ .66 126 - 42 -43 66 _ 67 128 - 43 -44 67 .68 128 - 45 -46 68 _ 69 129 - 48 -49 69 _ .70 130 - 49 -50 70 - 71 131 - 52 -53 71 _ -72 132 - 53 -54 91 . _ 92 133 - 54 -55 92 . .93 134 - 55 -56 93 . _ 94 135 - 56 -57 94 . -95 136 - 57 -58 95 _ -96 137 - 58 -59 96 -97 138 - 具有分別位於下列胺基酸 124 125 126 127 129 129 130 131 # 132 133 134 135 136 137 138 139 O:\92\92747.DOC -18- 200413407 59 - 60 97 - 60 - 61 98 - 61 - 62 99 - 其中該連接子（L2 Ser ; 98 139 - 140 99 140 - 141 100 141 - 142 或142 - 143 ; )係選自： Asn ;

Gly ； Thr ； GlySer ; AlaAla: GlySerGly ; GlyGlyGly ； GlyAsnGly ; GlyAlaGly ；

GlyThrGly ; AlaSerAla ； AlaAlaAla ; GlyGlyGlySer序列編號NO:778; SeΓGlyGlySerGlyGlySer序列編號N〇:781; GluPheGlyAsnMet序列編號NO:782; 01\^1^0以0以八3111^{序列編號>^0:783; O:\92\92747.DOC -19- 200413407 011^1^017〇17八311〇1}<}汐八3111^1序列編號1^〇:784; 01><}1}^认3卩]^^八1&01}^序列編號]\[〇:785; 86&1}<}1)^\311〇1}^序歹|]編號1\[〇:786; SerGlyGlyAsnGlySerGlyGlyAsnGlySerGlyGlyAsnGly 序列編號NO:788 ; SerGlyGlySerGlySerGlyGlySerGlySerGlyGlySerGly序列編號NO:790;

01}<}1}<}1}^6心1)<3^序列編號1^0:791; 01><}1}<}1>^沿1)<}1)<}17序列編號^[〇:792; 01><}1)<}1)^1〇1)<}1><}1>^沿1}<^序列編號?^0:793; 01><}1><}1}^心1><}15^1>^沿1}<}1}<}1}^沿汐序列編號风):794; 01><}1}<}1>^沿1>^1}^1}^101}<}15<}1}^心1}<}1><}坟序列編號：^0:795; GlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGly 序列編號NO : 796 ; ProProProTrpSerProArgProLeuGlyAlaThrAlaProThrAlaGlyGlnProProLeu 序列編號NO: 797 ; ProProProTrpSerProArgProLeuGlyAlaThrAlaProThr 序列編號ΝΟ:798 ;及 \^1〇1111〇11^^1?]161^八巧\^^1<}11^30〇1又1^111^111如^1：序列編號>1〇:799; 其中1^係可連接1及112之連接子，其為長度介於1至500 個胺基酸，具有含Gly，Asn，Ser，Thr或Ala之胺基酸序列之任何排列順序之多肽；且該造血蛋白之前端可選擇性毗鄰（甲硫胺酸，、（丙胺酸-1) 或（甲硫胺酸a，丙胺酸_1)。 4.根據申請專利範圍第1、2或3項之醫藥組合物，其中該造 O:\92\92747.DOC -20- 200413407 血細胞係CD34+細胞。 5·根據申請專利範圍第1、2或3項之醫藥組合物，其中該造血細胞係外周血細胞。 6 · —種用於治療患有腫瘤、感染或自體免疫疾病之人類之醫藥組合物，其包含經抗原脈衝之樹狀細胞祖細胞或成熟樹狀細胞，其係得自包含下列步騾之方法： (a) 以造血蛋白對該人類進行投藥，以使樹狀細胞祖細胞或成熟樹狀細胞活動化； (b) 以抽血或放血，取出該等樹狀細胞祖細胞或成熟樹狀細胞；及 (c) 以抗原對該等樹狀細胞祖細胞或成熟樹狀細胞進行脈衝而得該等經抗原脈衝之樹狀細胞祖細胞或成熟樹狀細胞；其中，該造血蛋白為下式之胺基酸序列：其中I係一種多肽，其為下式之經修飾flt-3配位體胺基酸序列： ThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArg 10 20 GluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAsp 30 40 GluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeu 50 60 LysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHis 70 80 PheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsn 90 100 IleSerArgLeuLeuGlnGluThrSerGluGlnLeuValMaLeuLysProTrpIleThr 110 120 ArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeu O:\92\92747.DOC -21 - 200413407 130 序列編號NO: 466 其中N-端係直接或經由一連接子（L2)而與C-端連結，該連接子可連接N-端及C-端，且具有分別位於下列胺基酸之新c_ -及N-端 28 - 29 42 -43 93 - 94 29 - 30 64 -65 94-95 30 - 31 65 -66 95 - 96 31 - 32 66 -67 96-97 32 - 33 86 -87 97-98 34 - 35 87 -88 98-99 36 - 37 88 -89 99-100 37 - 38 89 -90 100-101 38 - 39 90 91 101-102 39 - 40 91 -92 102-103 40 - 41 92 -93 41 - 42 其中R2係一種因子，其選自：flt-3、G-CSF及GM-CSF ;或 R2係一種多肽，其為下式之經修飾人類G-CSF胺基酸序列： 1 10 Xaa Xaa Xaa G;u Pro Ala Ser Ser Leu Pro Gin Ser Xaa 20 Leu Leu Xaa Xaa Xaa Glu Gin Val Xaa Lys Xaa Gin Gly Xaa Gly 30 40 Ala Xaa Leu Gin Glu Xaa Leu Xaa Ala Thr Tyr Lys Leu Xaa Xaa 50 Xaa Glu Xaa Xaa Val Xaa Xaa Gly His Ser Xaa Gly lie Pro Trp 60 70 Ala Pro Leu Ser Ser Xaa Pro Ser Xaa Ala Leu Xaa Leu Ala Gly 80 Xaa Leu Ser Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu O:\92\92747.DOC -22- 200413407 90 100 Leu Gin Ala Leu Glu Gly lie Ser Pro Glu Leu Gly Pro Thr Leu 110 Xaa Thr Leu Gin Xaa Asp Val Ala Asp Phe Ala Xaa Thr lie Trp 120 130 Gin Gin Met Glu Xaa Xaa Gly Met Ala Pro Ala Leu Gin Pro Thr 140 Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Xaa Gin Xaa Xaa Ala 150 160 Gly Gly Val Leu Val Ala Ser Xaa Leu Gin Xaa Phe Leu Xaa Xaa 170 Ser Tyr Arg Val Leu Xaa Xaa Leu Ala Gin Pro 序列編號 N〇：858 其中

第 1 位之 Xaa係 Thr、Ser、Arg、Tyr或 Gly ; 第2位之Xaa係Pro或Leu ; 第 3位之 Xaa係 Leu、Arg、Tyr或 Ser ; 第 13 位之 Xaa係 Phe、Ser、His、Thr或 Pro ; 第 16位之 Xaa係 Lys、Pro、Ser、Thr或 His ; 第 17位之 Xaa係 Cys、Ser、Gly、Ala、lie、Tyr或 Arg ; 第 18位之 Xaa係 Leu、Thr、Pro、His、lie或 Cys ; 第 22位之 Xaa係 Arg、Tyr、Ser、Thr或 Ala ;

第 24位之 Xaa係 lie、Pro、Tyr或 Leu ; 第27位之Xaa係Asp或Gly ; 第 3 0位之 Xaa係 Ala、lie、Leu或 Gly ; 第34位之Xaa係Lys或Ser ; 第36位之Xaa係Cys或Ser ; 第42位之Xaa係Cys或Ser ; 第 43 位之 Xaa係 His、Thr、Gly、Val、Lys、Trp、Ala、 Arg、Cys或 Leu ; 第 44位之 Xaa係 Pro、Gly、Arg、Asp、Val、Ala、His、 O:\92\92747.DOC -23- 200413407 Trp、Gin或 Thr ; 第 46位之 Xaa係 Glu、Arg、Phe、Arg、lie或 Ala ; 第47位之Xaa係Leu或Thr ; 第 49位之 Xaa係 Leu、Phe、Arg或 Ser ; 第 5 0位之 Xaa係 Leu、lie、His、Pro 或 Tyr ; 第54位之Xaa係Leu或His ; 第64位之Xaa係Cys或Ser ;

第67位之又&&係0111、1^3、1^11或€>^; 第 70位之 Xaa係 Gin、Pro、Leu、Arg或 Ser ; 第74位之Xaa係Cys或Ser ; 第 104 位之 Xaa 係 Asp、Gly 或 Val ; 第 1 08位之 Xaa係 Leu、Ala、Val、Arg、Trp、Gin或 Gly ; 第 11 5位之 Xaa係 Thr、His、Leu或 Ala ; 第 120位之 Xaa係 Gin、Gly、Arg、Lys或 His ; 第 123位之 Xaa係 Glu、Arg、Phe或 Thr ;

第 144位之 Xaa係 Phe、His、Arg、Pro、Leu、Gin或 Glu ; 第146位之Xaa係Arg或Gin ; 第147位之Xaa係Arg或Gin ; 第 156位之 Xaa係 His、Gly 或 Ser ; 第 1 59位之 Xaa係 Ser、Arg、Thr、Tyr、Val或 Gly ; 第 162位之 Xaa係 Glu、Leu、Gly 或 Trp ; 第 163 位之 Xaa 係 Va 卜 Gly、Arg 或 Ala ; 第 169位之 Xaa係 Arg、Ser、Leu、Arg或 Cys ; 第 170位之 Xaa係 His、Arg或 Ser ; O:\92\92747.DOC -24 - 200413407 其中選擇性自^端起之胺基酸及自端起之i·5胺基酸可自該經修飾之人類G- C S F胺基酸序列刪除；其中N-端係直接或經由一連接子（L 2)而與C-端連結，該連接子可連接N-端及C-端，且具有分別位於下列胺基酸之新C_&N_端； 38- 39 39- 40 40- 41 41- 42 42- 43 43- 44 45-46 48- 49 49- 50 52- 53 53- 54 54- 55 55- 56 56- 57 57- 58 58 _ 59 59-60 60 - 61 61-62 62- 63 63- 64 64- 65 65- 66 66- 67 67- 68 68- 69 69- 70 70- 71 71- 72 91- 92 92- 93 93- 94 94- 95 95- 96 96 - 97 97- 98 98- 99 99- 100 123- 124 124- 125 125- 126 126 - 127 128 - 129 128 - 129 129 - 130 130- 131 131- 132 132- 133 133- 134 134- 135 135- 136 136- 137 137 - 138 138-139 139 - 140 140- 141 141- 142 O:\92\92747.DOC -25- 200413407 或142 - 143 ; 其中該連接子（L2)係選自： Ser ； Asn ; Gly ； Thr ； GlySer ；

AlaAla: GlySerGly ； GlyGlyGly ； GlyAsnGly ; GlyAlaGly ; GlyThrGly ； AlaSerAla ; AlaAlaAla，

0汐0以0以861*序列編號1^0:778; GlyGlyClySerGlyGlyGlySerGlyGlyGlySer序列編號NO:780; SeI·GlyGlySerGlyGlySer序列編號NO:781; 01逆1^0汐八311^^'1序列編號1^0:782; GluPheGlyGlyAsnMet序列編號Nα·783; 011^1^017〇以八311〇以017八311?^^序列編號1^0:784; GlyGlySerAspMetAlaGly序列編號NO:785; 861<}17〇17八311〇以序列編號1^0:786; O:\92\92747.DOC -26- 200413407 8。沿1}<}1}^^11〇1}^€心1}<}1}^^11〇1}^序列編號]^0:787; SerGlyGlyAsnGlySerGlyGlyAsnGlySerGlyGlyAsnGly 序列編號n〇:788 ; 8〇心1><51>^6犯1^^心1><}1}^沿汐序列編號]^0:789; 8〇沿1}<}1)^€心1>^犯1}<51}^6沿1)^61<}1}<}1}^6沿1)^序列編號^[〇:790; GlyGlyGlySerGlyGly 序列編號NO:791 ; GlyGlyGlySerGlyGlyGlySerGlyGly序列編號NO:793;

01><}1}<}1}^6沿1}<}1}<}1}^6沿1}<}1}<}1>^心1；7序列編號：^0:794; GlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGly 序列編號NO : 796 ; ProProProTrpSerProArgProLeuGlyAlaThrAlaProThrAlaGlyGlnProProLeu 序列編號NO: 797 ; ProProProTYpSerProArgProLeuGlyAlaThrAlaProThr 序列編號NO:798 ;及 \^101111111'\&1?1^1^八租\^1861〇11^\3卩01}1^111^1111^^1：序列編號1<[〇:799; 其中1^係可連接1^及112之連接子，其為長度介於1至500 φ 個胺基酸，具有含Gly，Asn，Ser，Thr或Ala之胺基酸序列之任何排列順序之多肽；且該造血蛋白之前端可選擇性毗鄰（甲硫胺酸_ι)、（丙胺酸-1) 或（甲硫胺酸·2，丙胺酸，。 7·根據申請專利範圍第6項之醫藥組合物，其中該方法尚包含步騾（a)中，以一或多種選自GM-CSF、IL-4、TNF_ α、幹細胞因子（SCF)、flt-3配位體、IL-3、IL-3變體、IL-3 •fei體融合蛋白、及多功能造血素受體促效劑之因子進行 O:\92\92747.DOC -27- 200413407 8· 9. 10. 11. 12. 投藥。根據申請專利範圍第6項之醫藥組合物，其中該方法尚包含下列步驟；在含有該造血蛋白之生長培養基中，培養该等取自步騾（b)之樹狀細胞前體細胞或成熟樹狀細胞。根據申凊專利範圍第7項之醫藥組合物，其中該方法尚包含下列步騾：在含有該造血蛋白之生長培養基中，培養該等取自步騾（b)之樹狀細胞前體細胞或成熟樹狀細胞。根據申請專利範圍第8項之醫藥組合物，其中該生長培養基尚含有一或多種選自GM-CSF、IL-4、TNF- α、幹細胞因子（SCF)、flt-3配位體、il-3、IL-3變體、IL-3變體融合蛋白、及多功能造血素受體促效劑之因子。根據申請專利範圍第9項之醫藥組合物，其中該生長培養基尚含有一或多種選自GM-CSF、IL-4、TNF- α、幹細胞因子（SCF)、flt-3配位體、il-3、IL-3變體、IL_3變體融合蛋白、及多功能造血素受體促效劑之因子。一種用於治療患有腫瘤、感染或自體免疫疾病之人類之醫藥組合物，其係置回該人類體内，包含樹狀細胞前體細胞或成熟樹狀細胞，其係得自包含下列步驟之方法： (a) 以抽血或放血，自該人類體内取出造血祖細胞或 CD34 +細胞；及 (b) 在含有造血蛋白之生長培養基中培養該等造血祖細胞或CD34+細胞，以製備樹狀細胞前體細胞或成熟樹狀細胞；其中，該造血蛋白為下式之胺基酸序列： O:\92\92747.DOC -28 - Ri-Li-R〗、R〗-Li-Ri、Ri-R〗、或 R2-Ri 其中Ri係一種多肽，其為下式之經修飾flt-3配位體胺基酸序列： ThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArg 10 20 GluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAsp 30 40 GluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeu 50 60 LysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHis 70 80 PheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsn 90 100 工leSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysPr〇TrpIleThr 110 120 ArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeu 130 序列編號NO: 466 其中N-端係直接或經由一連接子（L2)而與C-端連結，該連接子可連接N-端及C-端，且具有分別位於下列胺基酸之新C-及N-端； 28 -29 42 - 43 93-94 29 -30 64 - 65 94 - 95 30 -31 65 - 66 95 - 96 31 -32 66 - 67 96-97 32 -33 86 - 87 97-98 34 -35 87 - 88 98-99 36 -37 88 - 89 99-100 37 -38 89 - 90 100-101 38 -39 90 - 91 101 - 102 39 -40 91 - 92 102 - 103 O:\92\92747.DOC - 29 - 200413407 40 - 41 92 - 93 41-42 ；其中R2係一種因子，其選自：flt-3、G-CSF及GM-CSF ;或 R2係一種多肽，其為下式之經修飾人類G-CSF胺基酸序列： 1 10 Xaa Xaa Xaa G;u Pro Ala Ser Ser Leu Pro Gin Ser Xaa 20 Leu Leu Xaa Xaa Xaa Glu Gin Val Xaa Lys Xaa Gin Gly Xaa Gly 30 40 Ala Xaa Leu Gin Glu Xaa Leu Xaa Ala Thr Tyr Lys Leu Xaa Xaa 50

Xaa Glu Xaa Xaa Val Xaa Xaa Gly His Ser Xaa Gly lie Pro Trp 60 70 Ala Pro Leu Ser Ser Xaa Pro Ser Xaa Ala Leu Xaa Leu Ala Gly 80 Xaa Leu Ser Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu 90 100 Leu Gin Ala Leu Glu Gly lie Ser Pro Glu Leu Gly Pro Thr Leu 110 Xaa Thr Leu Gin Xaa Asp Val Ala Asp Phe Ala Xaa Thr 工le Trp 120 130 Gin Gin Met Glu Xaa Xaa Gly Met Ala Pro Ala Leu Gin Pro Thr 140 Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Xaa Gin Xaa Xaa Ala 150 160 Gly Gly Val Leu Val Ala Ser Xaa Leu Gin Xaa Phe Leu Xaa Xaa 17 0 Ser Tyr Arg Val Leu Xaa Xaa Leu Ala Gin Pro Jf 歹l]編號 NO: 858 其中第 1位之 Xaa係 Thr、Ser、Arg、Tyr或 Gly ; 第2位之Xaa係Pro或Leu ; 第 3位之 Xaa係 Leu、Arg、Tyr 或 Ser ; 第 13位之 Xaa係 Phe、Ser、His、Thr或 Pro ; 第 16位之 Xaa係 Lys、Pro、Ser、Thr或 His ; 第 17 位之 Xaa 係 Cys、Ser、Gly、Ala、lie、Tyr 或 Arg ; O:\92\92747.DOC -30- 200413407 第 18位之 Xaa係 Leu、Thr、Pro、His、lie或 Cys ; 第 22 位之 Xaa係 Arg、Tyr、Ser、Thr 或 Ala; 第 24位之 Xaa係 lie、Pro、Tyr 或 Leu ; 第27位之Xaa係Asp或Gly ; 第 3 0位之 Xaa係 Ala、lie、Leu或 Gly ; 第34位之又3&係1^3或861·; 第36位之又&&係€73或861·; 第42位之Xaa係Cys或Ser ; 第 43 位之 Xaa係 His、Thr、Gly、Val、Lys、Trp、Ala、 Arg、Cys或 Leu ; 第 44位之 Xaa係 Pro、Gly、Arg、Asp、Val、Ala、His、 Trp、Gin或 Thr ; 第 46位之 Xaa係 Glu、Arg、Phe、Arg、lie或 Ala ; 第47位之Xaa係Leu或Thr ; 第 49位之 Xaa係 Leu、Phe、Arg或 Ser ; 第 50位之 Xaa係 Leu、lie、His、Pro或 Tyr ; 第54位之Xaa係Leu或His ; 第64位之Xaa係Cys或Ser ; 第 67位之 Xaa係 Gin、Lys、Leu或 Cys ; 第 70位之 Xaa係 Gin、Pro、Leu、Arg或 Ser ; 第74位之Xaa係Cys或Ser ; 第 104位之 Xaa係 Asp、Gly 或 Val ; 第 108位之 Xaa係 Leu、Ala、Val、Arg、Trp、Gin或 Gly ; 第 115位之 Xaa係 Thr、His、Leu或 Ala ; O:\92\92747.DOC -31 - 200413407 第 120位之 Xaa係 Gin、Gly、Arg、Lys或 His ; 第 123位之 Xaa係 Glu、Arg、Phe或 Thr ; 第 144位之 Xaa係 Phe、His、Arg、Pro、Leu、Gin或 Glu ; 第146位之Xaa係Arg或Gin ; 第147位之Xaa係Arg或Gin ; 第 156位之 Xaa係 His、Gly或 Ser ; 第 1 59位之 Xaa係 Ser、Arg、Thr、Tyr、Val或 Gly ; 第 162位之 Xaa係 Glu、Leu、Gly 或 Trp ; 第 163位之 Xaa係 Va卜 Gly、Arg或 Ala ; 第 169位之 Xaa係 Arg、Ser、Leu、Arg或 Cys ; 第 170 位之 Xaa 係 His、Arg 或 Ser ; 其中選擇性自N-端起之1-11胺基酸及自C-端起之1_5胺基酸可自該經修飾之人類G-CSF胺基酸序列刪除；其中N-端係直接或經由一連接子（L2)而與C-端連結，該 123 - 124 124 - 125 125 - 126 126-127 128-129 128 - 129 129 - 130 130-131 連接子可連接N-端及C-端，且具有分別位於下列胺基酸之新C-及N-端； 38 - 39 62 - 63 39 - 40 63 - 64 40 - 41 64 - 65 41 - 42 65 - 66 42 - 43 66 - 67 43 - 44 67 - 68 45 - 46 68 - 69 48 - 49 69 - 70 O:\92\92747.DOC •32- 200413407 49 -50 70 - 52 -53 71 - 53 -54 91 - 54 -55 92 - 55 -56 93 - 56 -57 94 - 57 -58 95 - 58 -59 96 - 59 -60 97 - 60 -61 98 - 61 -62 99 - 其中該連接子（l2 Ser ; Asn ; Gly ； Thr ； GlySer ； AlaAla: GlySerGly ; GlyGlyGly ； GlyAsnGly ; GlyAlaGly ； GlyThrGly ； 131-132 132 - 133 133- 134 134- 135 135- 136 136 - 137 137-138 138 - 139 139- 140 140- 141 141 - 142 或142 - 143 ; 選自： O:\92\92747.DOC -33 - 200413407 AlaSerAla ； AlaAlaAla ; 0以0汐0汐8。1^序列編號>10:778; 01}<}1}<^^沿13<}1}<}1>^1"序列編號>10:779; 8€&1)^}1>^力1}<}15^1*序列編號>|〇:781; 01迎1^01}^811^^序列編號：^0:782;

011^1^01><}1>^\511\^1:序列編號>10:783; 011^1^0汐01>^311〇汐017八311^^序列編號]^0:784; 01><}1}^认5卩]^^八1&0以序列編號]^0:785; 8©犷01}<}1}^\811〇17序列編號]^0:786; 86化汐0以八311〇的6沿17〇17八311〇17序列編號1^0:787; SerGlyGlyAsnGlySerGlyGlyAsnGlySerGlyGlyAsnGly 序列編號n〇:788 ; 8亡沿1><}1}^心1}^沿1}<}1}^沿17序列編號风):789; 86心1><^^心1}^心1}<}1}^沿1}^仰}<}1}^幻1}^序列編號1\1〇:790;

〇1}<}1><}13^0沿1)<^序列編號1\[〇:791; 01}<}1}<}1>^犯1}<}1)<}汐序列編號^):792; 01}<}1}<}13^心1}<}1><}15^心1}<}1}^序列編號1^0:793; 01}<}1><}1>^心1><}1}^1}^沿1}<}13<}1}^沿汐序列編號>10:794; 01><}1)<}1}^€心1)<}1)<}1}^101)<}1}<^1}^沿1}<}15<}17序列編號^[〇:795; GlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGly 序列編號NO : 796 ; ProProProTrpSerProArgProLeuGlyAlaThrAlaProThrAlaGlyGlnProProLeu 序列編號NO: 797 ; O:\92\92747.DOC -34- 200413407 ProProProTrpSerProArgProLeuGlyAlaThrAlaProThr 序列編號NO:798 ;及其中1^係可連接1及112之連接子，其為長度介於1至500 個胺基酸，具有含Gly，Asn，Ser，Thr或Ala之胺基酸序列之任何排列順序之多肽；且該造血蛋白之前端可選擇性毗鄰（甲硫胺酸4)、（丙胺酸-1) 或（甲硫胺酸·2，丙胺酸，。 13. —種治療患有腫瘤、感染或自體免疫疾病之人類之醫藥組合物，其係置回該人類體内，包含經抗原脈衝之樹狀前體細胞或成熟樹狀細胞，係得自包含下列步驟之方法· (a) 以抽血或放血，自該人類體内取出造血祖細胞或 CD34 +細月包； (b) 在含有造血蛋白之生長培養基中培養該等造血祖細胞或CD34+細胞，以製備樹狀細胞前體細胞或成熟樹狀細胞；及 (c) 以抗原對該等樹狀細胞前體細胞或成熟樹狀細胞進行脈衝；其中，該造血蛋白為下式之胺基酸序列： Ri-L^-R〗、R2-Li_Ri、-R〗、或其中Ri係一種多肽，其為下式之經修飾flt-3配位體胺基酸序列： ThrGlnAspCysSerPheGlnHisSerProIleSerSerAspPheAlaValLysIleArg 10 20 GluLeuSerAspTyrLeuLeuGlnAspTyrProValThrValAlaSerAsnLeuGlnAsp 30 40 GluGluLeuCysGlyGlyLeuTrpArgLeuValLeuAlaGlnArgTrpMetGluArgLeu O:\92\92747.DOC -35- 200413407 60 50 LysThrValAlaGlySerLysMetGlnGlyLeuLeuGluArgValAsnThrGluIleHis 70 80 PheValThrLysCysAlaPheGlnProProProSerCysLeuArgPheValGlnThrAsn 90 100 工leSerArgLeuLeuGlnGluThrSerGluGlnLeuValAlaLeuLysProTrpIleThr 110 120 ArgGlnAsnPheSerArgCysLeuGluLeuGlnCysGlnProAspSerSerThrLeu 130 序列編號NO: 466 其中N-端係直接或經由一連接子（L2)而與C-端連結，該連接子可連接N-端及C-端，且- 新C· •及N-端 9 28 - 29 42 - 43 93 - 94 29 - 30 64 - 65 94 - 95 30 - 31 65 - 66 95 - 96 31 - 32 66 - 67 96 - 97 32 - 33 86 - 87 97 - 98 34 - 35 87 - 88 98 - 99 36 - 37 88 - 89 99 - 100 37 - 38 89 - 90 100 -101 38 - 39 90 - 91 101 -102 39 - 40 91 - 92 102 -103 40 - 41 92 - 93 41 - 42 其中R2係一種因子，其選自：flt_3、G-CSF及GM-CSF ;或 R2係一種多肽，其為下式之經修飾人類G-CSF胺基酸序列： 1 10 Xaa Xaa Xaa G;u Pro Ala Ser Ser Leu Pro Gin Ser Xaa 20 Leu Leu Xaa Xaa Xaa Glu Gin Val Xaa Lys Xaa Gin Gly xaa Gly O:\92\92747.DOC -36- 200413407 30 40 Ala Xaa Leu Gin Glu Xaa Leu Xaa Ala Thr Tyr Lys Leu Xaa Xaa 50 Xaa Glu Xaa Xaa Val Xaa Xaa Gly His Ser Xaa Gly lie Pro Trp 60 70 Ala Pro Leu Ser Ser Xaa Pro Ser Xaa Ala Leu Xaa Leu Ala Gly 80 Xaa Leu Ser Gin Leu His Ser Gly Leu Phe Leu Tyr Gin Gly Leu 90 100 Leu Gin Ala Leu Glu Gly lie Ser Pro Glu Leu Gly Pro Thr Leu 110 Xaa Thr Leu Gin Xaa Asp Val Ala Asp Phe Ala Xaa Thr 工le Trp 120 130 Gin Gin Met Glu Xaa Xaa Gly Met Ala Pro Ala Leu Gin Pro Thr 140 Gin Gly Ala Met Pro Ala Phe Ala Ser Ala Xaa Gin Xaa Xaa Ala 150 160 Gly Gly Val Leu Val Ala Ser Xaa Leu Gin Xaa Phe Leu Xaa Xaa 170 Ser Tyr Arg Val Leu Xaa Xaa Leu Ala Gin Pro 序列編號 NO: 858 其中第 1位之 Xaa係 Thr、Ser、Arg、Tyr或 Gly ; 第2位之Xaa係Pro或Leu ; 第 3位之 Xaa係 Leu、Arg、Tyr或 Ser ; 第 13位之 Xaa係 Phe、Ser、His、Thr或 Pro ; 第 16位之 Xaa係 Lys、Pro、Ser、Thr或 His ; 第 17 位之 Xaa 係 Cys、Ser、Gly、Ala、lie、Tyr 或 Arg ; 第 18位之 Xaa係 Leu、Thr、Pro、His、lie或 Cys ; 第 22位之 Xaa係 Arg、Tyr、Ser、Thr或 Ala ; 第 24位之 Xaa係 lie、Pro、Tyr或 Leu ; 第27位之Xaa係Asp或Gly ; 第 3 0位之 Xaa係 Ala、lie、Leu或 Gly ; 第3 4位之Xaa係Lys或Ser ; 第36位之Xaa係Cys或Ser ; O:\92\92747.DOC -37- 200413407 第42位之Xaa係Cys或Ser ; 第 43 位之 Xaa係 His、Thr、Gly、Val、Lys、Trp、Ala、 Arg、Cys或 Leu ; 第 44位之 Xaa係 Pro、Gly、Arg、Asp、Val、Ala、His、 Trp、Gin或 Thr ; 第 46位之 Xaa係 Glu、Arg、Phe、Arg、lie或 Ala ; 第47位之Xaa係Leii或Thr ; 第 49位之 Xaa係 Leu、Phe、Arg或 Ser ; 第 5 0位之 Xaa係 Leu、lie、His、Pro或 Tyr ; 第54位之Xaa係Leu或His ; 第64位之Xaa係Cys或Ser ; 第 67位之 Xaa係 Gin、Lys、Leu或 Cys ; 第 70位之 Xaa係 Gin、Pro、Leu、Arg或 Ser ; 第74位之Xaa係Cys或Ser ; 第 104 位之 Xaa 係 Asp、Gly 或 Val ; 第 108位之 Xaa係 Leu、Ala、Val、Arg、Trp、Gin或 Gly ; 第 115位之 Xaa係 Thr、His、Leu或 Ala ; 第 120位之 Xaa係 Gin、Gly、Arg、Lys 或 His ; 第 123位之 Xaa係 Glu、Arg、Phe或 Thr ; 第 144位之 Xaa係 Phe、His、Arg、Pro、Leu、Gin或 Glu ; 第146位之Xaa係Arg或Gin ; 第147位之Xaa係Arg或Gin ; 第 156 位之 Xaa 係 His、Gly 或 Ser ; 第 1 59位之 Xaa係 Ser、Arg、Thr、Tyr、Val或 Gly ; O:\92\92747.DOC -38- 200413407 第 162位之 Xaa係 Glu、Leu、Gly 或 Trp ; 第 163 位之 Xaa係 Val、Gly、Arg或 Ala ; 第 169位之 Xaa係 Arg、Ser、Leu、Arg或 Cys ; 第 170位之 Xaa係 His、Arg或 Ser ; 其中選擇性自N-端起之1-11胺基酸及自C-端起之le5胺基酸可自該經修飾之人類G-CSF胺基酸序列刪除；其中N-端係直接或經由一連接子（L 2)而與c-端連結，該連接子可連接N-端及C-端，且具有分別位於下列胺基酸之新C-及N-端； 38 - 39 62 - 63 123 - 124 39 - 40 63 - 64 124 - 125 40 - 41 64 - 65 125 - 126 41 - 42 65 - 66 126 - 127 42 - 43 66 - 67 128 - 129 43 - 44 67 - 68 128 - 129 45 - 46 68 - 69 129 - 130 48 - 49 69 - 70 130 - 131 49 - 50 70 - 71 131 - 132 52 - 53 71 - 72 132 - 133 53 - 54 91 - 92 133 _ 134 54 - 55 92 - 93 134 - 135 55 - 56 93 - 94 135 - 136 56 - 57 94 - 95 136 - 137 57 - 58 95 - 96 137 - 138 O:\92\92747.DOC - 39 _ 200413407 58 - 59 96 - 97 138 - 139 59-60 97-98 139-140 60 - 61 98 - 99 140 - 141 61 - 62 99 - 100 141 - 142 或142 - 143 ; 其中該連接子（l2m系選自：

Ser ; Asn ； Gly ； Thr ； GlySer ； AlaAla: GlySerGly ; GlyGlyGly ； GlyAsnGly ；

GlyAlaGly ; GlyThrGly ; AlaSerAla ; AlaAlaAla， 0汐0汐0汐8£1'序列編號1^0:778; GlyGlyGlySerGlyGlyGlySer序列編號NO:779; GlyGlyClySerGlyGlyGlySerGlyGlyGlySer序列編號NO:780; 01沾1^0汐八311^^1序列編號1^0:782; O:\92\92747.DOC -40- 200413407 0111?1^01><}1}^\311]^1:序列編號：^0:783; 0111卩1^0以0以八3110汐0汐八311^似序列編號>10:784; 01}<}1}^认3卩]\^八1&017序列編號1\[〇:785; 86力以0以八311〇以序列編號1^0:786; SerGlyGlyAsnGlySerGlyGlyAsnGlySerGlyGlyAsnGly 序列編號n〇:788 ; 86&1><}1>^1<}1>^心1><}1}^沿汐序列編號>^0:789;

GlyGlyGlySerGlyGly序列編號NO:791; GlyGlyGlySerGlyGlyGly序列編號NO:792; 01><}1><}1}^沿1><}1}<51}^沿1}<}1}^序列編號^):793; 01}<}1}<}1}^1〇1)<}1)^1}^]^1)<}1)<}1}^沿汐序列編號：^0:794; 01><}1><}1>^1：01}<}1}<}1}^101)<}1}<}1}^沿1)<}1}<^序列編號：^0:795; GlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGlyGlyGlySerGly 序列編號NO :796 ;

ProProProTrpSerProArgProLeuGlyAlaThrAlaProThrAlaGlyGlnProProLeu 序列編號NO: 797 ; ProProProTrpSerProArgProLeuGlyAlaThrAlaProThr 序列編號NO:798 ;及 \^101111111*\^1?1^1^八租\^186心11^3卩01}^1^111^111111861：序列編號]^0:799; 其中1^係可連接1^及112之連接子，其為長度介於1至500 個胺基酸，具有含Gly，Asn，Ser，Thr或Ala之胺基酸序列之任何排列順序之多肽；且該造血蛋白之前端可選擇性毗鄰（甲硫胺酸_1)、（丙胺酸，或（甲硫胺酸·2，丙胺酸“）。 O:\92\92747.DOC -41 - 200413407 14 ·根據申請專利範圍第12項之醫藥組合物，其中該方法尚包含下列步騾：在進行培養之前，將該等造血祖細胞或 CD34 +細胞與其他細胞分離。 15·根據申請專利範圍第13項之醫藥組合物，其中該方法尚包含下列步驟：在進行培養之前，將該等造血祖細胞或 CD34 +細胞與其他細胞分離。 16·根據申請專利範圍第12項之醫藥組合物，其中該生長培養基尚含有，·一或多種選自GM_CSF、IL-4、TNF- α、幹細胞因子（SCF)、flt-3配位體、IL_3、IL-3變體、IL-3變體融合蛋白、及多功能造血素受體促效劑之因子。 17·根據申請專利範圍第Π項之醫藥組合物，其中該生長培養基尚含有；一或多種選自GM-CSF、IL-4、TNF- α、幹細胞因子（SCF)、flt-3配位體、IL-3、IL-3變體、IL-3變體融合蛋白、及多功能造血素受體促效劑之因子。 •根據申請專利範圍第14項之醫藥組合物，其中該生長培養基尚含有；一或多種選自GM-CSF、IL-4、TNF- α、幹細胞因子（SCF)、flt-3配位體、il-3、IL_3變體、IL-3變體昌泛蛋白、及多功能造血素受體促效劑之因子。 19·根據申請專利範圍第15項之醫藥組合物，其中該生長培養基尚含有；一或多種選自GM-CSF、IL-4、TNF- α、幹、、、田胞因子（SCF)、flt_3配位體、IL-3、IL_3變體、IL-3變體融η蛋白、及多功能造血素受體促效劑之因子。根據申請專利範圍第i、2、3、6、12或13項之醫藥組合斗为，甘 ’ ”中該造血蛋白係選自：序列辨識編號：659，序列 0:\92\92747.D0< 200413407 辨識編號：705,序列辨識編號：7〇6，序列辨識編號： 7〇7，序列辨識編號：7⑽，序列辨識編號：，序列辨識編號、:，710’序列辨識編號：川，序列辨識編號·· 712 ’序列辨識編號：713 ’序列辨識編?虎：714，序列辨識編號：715,序列辨識編號：⑶，序列辨識編號：72/ 序列辨識編號：725,序列辨識編號：以，序列辨識編唬:、728’序列辨識編號：729,序列辨識編號：73〇,序列辨識 '扁號· 731 ’序列辨識編號·· 732，序列辨識編號 :733’序列辨識編號：734，序列辨識編號：735，序列辦識編號：736，彳列辨識編號：737,序列辨識編號：頂，序列辨識編號：739,序列辨識編號：，序列辨識編號、:、741，序列辨識編號：742,序列辨識編號：743 ，序列辨識編號·· 744，序列辨識編號：745，序列辨識編號、:、746，序列辨識編號：747,序列辨識編號：7; 序列辨識編號：749，彳列辨識編號：750，彳列辨識編號：751，序列辨識編號：752，序列辨識編號·· ％，序列辨識編號·· 766，及序列辨識編號：767。 21.

根據申請專利範圍第卜2、3、6、12或13項之醫藥扭人物，其中該造血蛋白係由選自下列之核酸分子所編碼: 序列辨識編號·· 198，序列辨識編號：2料，序列辨識編號· 245 ’序列辨識編號：246，序列辨識編號：μ?，序列辨識編號：248,序列辨識編號：249，序列辨識編號： 250 ’序列辨識編號·· 251，序列辨識編號·· 252，序列辨識編號：253，序列辨識編號：254,序列辨識編號：， O:\92\92747.DOC -43- 200413407 序列辨識編號：263，序列辨識編號：264,序列辨識編號：265 ’序列辨識編號：266，序列辨識編號：26?，序列辨識編號:268’序列辨識編號：269,序列辨識編號: 270 ’序列辨識編號：271，序列辨識編號：奶，序列辨夺线編· 2 7 3 ’序列辨短魏* ·，7 ^ — 汴幻許硪編唬· 274，序列辨識編號：275，序列辨識編號：276，序列辨識編號：277，序列辨識編號：278,序列辨識編號：279’序列辨識編號：，序列辨識編號：281，序列辨識編號：282，序列辨識編號： 283,序列辨識編號：284，序列辨識編號：285,序列辨識編號：286,序列辨識編號：287，序列辨識編號：288, 序列辨識編號：289，序列辨識編號：29〇，序列辨識編號：291，及序列辨識編號：292。 O:\92\92747.DOC 44 -