WO1998017810A3 - Agonistes recepteurs hematopoietiques chimeriques multifonctionnels - Google Patents

Agonistes recepteurs hematopoietiques chimeriques multifonctionnels Download PDF

Info

Publication number
WO1998017810A3
WO1998017810A3 PCT/US1997/020037 US9720037W WO9817810A3 WO 1998017810 A3 WO1998017810 A3 WO 1998017810A3 US 9720037 W US9720037 W US 9720037W WO 9817810 A3 WO9817810 A3 WO 9817810A3
Authority
WO
WIPO (PCT)
Prior art keywords
functional chimeric
hematopoietic receptor
chimeric hematopoietic
receptor agonists
receptor agonist
Prior art date
Application number
PCT/US1997/020037
Other languages
English (en)
Other versions
WO1998017810A2 (fr
Inventor
Wherter Charles A Mc
Yiqing Feng
Kearn John P Mc
Neena L Summers
Nicholas R Staten
Philip R Streeter
John C Minnerly
Nancy I Minster
Susan L Woulfe
Original Assignee
Searle & Co
Wherter Charles A Mc
Yiqing Feng
Kearn John P Mc
Neena L Summers
Nicholas R Staten
Philip R Streeter
John C Minnerly
Nancy I Minster
Susan L Woulfe
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co, Wherter Charles A Mc, Yiqing Feng, Kearn John P Mc, Neena L Summers, Nicholas R Staten, Philip R Streeter, John C Minnerly, Nancy I Minster, Susan L Woulfe filed Critical Searle & Co
Priority to IL12956597A priority Critical patent/IL129565A0/xx
Priority to JP51975498A priority patent/JP2001504689A/ja
Priority to RO99-00480A priority patent/RO120919B1/ro
Priority to BR9713668-9A priority patent/BR9713668A/pt
Priority to EP97946495A priority patent/EP0935663A2/fr
Priority to CA002268742A priority patent/CA2268742A1/fr
Priority to AU51652/98A priority patent/AU725547B2/en
Priority to NZ335382A priority patent/NZ335382A/xx
Publication of WO1998017810A2 publication Critical patent/WO1998017810A2/fr
Publication of WO1998017810A3 publication Critical patent/WO1998017810A3/fr
Priority to NO991948A priority patent/NO991948L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5403—IL-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention concerne de nouvelles protéines agonistes réceptrices hématopoïétiques chimériques multifonctionnelles, des ADN qui codent les protéines agonistes réceptrices hématopoïétiques chimériques multifonctionnelles, des procédés de préparation de protéines agonistes réceptrices hématopoïétiques chimériques multifonctionnelles et des procédés d'utilisation des protéines agonistes réceptrices hématopoïétiques chimériques multifonctionnelles.
PCT/US1997/020037 1996-10-25 1997-10-23 Agonistes recepteurs hematopoietiques chimeriques multifonctionnels WO1998017810A2 (fr)

Priority Applications (9)

Application Number Priority Date Filing Date Title
IL12956597A IL129565A0 (en) 1996-10-25 1997-10-23 Multi-functional chimeric hematopoietic receptor agonists
JP51975498A JP2001504689A (ja) 1996-10-25 1997-10-23 多機能性キメラ造血レセプターアゴニスト
RO99-00480A RO120919B1 (ro) 1996-10-25 1997-10-23 Proteină hematopoietină, moleculă de acid nucleiccare o codifică, compoziţie farmaceutică şi utilizarea proteinei
BR9713668-9A BR9713668A (pt) 1996-10-25 1997-10-23 Agonistas de receptores hematopoiéticos quiméricos multifuncionais
EP97946495A EP0935663A2 (fr) 1996-10-25 1997-10-23 Agonistes recepteurs hematopoietiques chimeriques multifonctionnels
CA002268742A CA2268742A1 (fr) 1996-10-25 1997-10-23 Agonistes recepteurs hematopoietiques chimeriques multifonctionnels
AU51652/98A AU725547B2 (en) 1996-10-25 1997-10-23 Multi-functional chimeric hematopoietic receptor agonists
NZ335382A NZ335382A (en) 1996-10-25 1997-10-23 Multi-functional chimeric hematopoietic polypeptides of IL-3, GCSF, Flt3L, EPO, stem cell factor, cmpl link with or without linker group consisting of Alanine, Glycine and/or Serine for treating autoimmune and tumour related diseases
NO991948A NO991948L (no) 1996-10-25 1999-04-23 Multifunksjonelle kimere hematopoetiske reseptoragonister

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2962996P 1996-10-25 1996-10-25
US60/029,629 1996-10-25

Publications (2)

Publication Number Publication Date
WO1998017810A2 WO1998017810A2 (fr) 1998-04-30
WO1998017810A3 true WO1998017810A3 (fr) 1998-10-15

Family

ID=21850035

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/020037 WO1998017810A2 (fr) 1996-10-25 1997-10-23 Agonistes recepteurs hematopoietiques chimeriques multifonctionnels

Country Status (17)

Country Link
EP (1) EP0935663A2 (fr)
JP (1) JP2001504689A (fr)
KR (1) KR100497423B1 (fr)
AR (1) AR010041A1 (fr)
AU (1) AU725547B2 (fr)
BR (1) BR9713668A (fr)
CA (1) CA2268742A1 (fr)
CZ (1) CZ295843B6 (fr)
IL (1) IL129565A0 (fr)
NO (1) NO991948L (fr)
NZ (1) NZ335382A (fr)
PL (1) PL333023A1 (fr)
RO (1) RO120919B1 (fr)
RU (2) RU2245887C2 (fr)
TW (2) TW591035B (fr)
WO (1) WO1998017810A2 (fr)
ZA (1) ZA979607B (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5581476A (en) 1993-01-28 1996-12-03 Amgen Inc. Computer-based methods and articles of manufacture for preparing G-CSF analogs
US20020137890A1 (en) * 1997-03-31 2002-09-26 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
BR9808514A (pt) * 1997-04-11 2000-05-23 Searle & Co Proteìnas quiméricas do ligante flt3
BR9905867A (pt) * 1998-11-06 2001-01-23 Bio Sidus S A Linhagem celular produtora de eritropoietina humana recombinante e a eritropoietina humana recombinante produzida por esta célula
WO2002101047A1 (fr) * 2001-06-12 2002-12-19 Smithkline Beecham Corporation Procede d'identification de composes modulant les activites du gene 1 de reponse primaire a l'epo, eprg1
MXPA04000231A (es) 2001-07-11 2004-05-04 Maxygen Holdings Ltd Conjugados del factor de estimulacion de colonias de granulocitos.
WO2005047461A2 (fr) 2003-08-18 2005-05-26 The Regents Of The University Of California Bibliotheques d'affichage de polypeptides et procede de fabrication et d'utilisation de celle-ci
CA2607844C (fr) 2005-06-01 2012-07-10 Maxygen Holdings Ltd. Polypeptides g-csf pegyles et procedes de production correspondants
US7550433B2 (en) * 2005-06-03 2009-06-23 Affymax, Inc. Erythropoietin receptor peptide formulations and uses
WO2007027935A2 (fr) 2005-08-31 2007-03-08 The Regents Of The University Of California Bibliotheques cellulaires de sequences peptidiques (clips) et procedes d'utilisation de celles-ci
WO2007098548A1 (fr) * 2006-03-01 2007-09-07 Apollo Life Sciences Limited Molécule et chimères de cette molécule
WO2009014726A1 (fr) * 2007-07-26 2009-01-29 The Regents Of The University Of California Procédés permettant d'améliorer un affichage de cellules bactériennes de protéines et de peptides
US10071109B2 (en) 2013-11-06 2018-09-11 Molecular Templates, Inc. Predictive biomarker for hypoxia-activated prodrug therapy
EP3946409A4 (fr) * 2019-03-28 2023-06-21 Orionis Biosciences, Inc. Protéines chimériques basées sur le ligand de la tyrosine kinase-3 de type fms (flt3l)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992006116A1 (fr) * 1990-09-28 1992-04-16 Ortho Pharmaceutical Corporation Facteurs de croissance hybride
US5376367A (en) * 1991-11-22 1994-12-27 Immunex Corporation Fusion proteins comprising MGF and IL-3
WO1995021254A1 (fr) * 1994-02-04 1995-08-10 G. D. Searle & Co. Proteine fusionnee a plusieurs variants d'il-3 et a activite hematopoietique
WO1995021197A1 (fr) * 1994-02-04 1995-08-10 G.D. Searle & Co. Proteine hybride variante de l'il-3 favorisant l'hematopoiese
WO1995027732A2 (fr) * 1994-04-08 1995-10-19 The Government Of The United States Of America, Represented By The Secretary Of The Department Of Health And Human Services Ligands et molecules chimeriques a permutation circulaire

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992006116A1 (fr) * 1990-09-28 1992-04-16 Ortho Pharmaceutical Corporation Facteurs de croissance hybride
US5376367A (en) * 1991-11-22 1994-12-27 Immunex Corporation Fusion proteins comprising MGF and IL-3
WO1995021254A1 (fr) * 1994-02-04 1995-08-10 G. D. Searle & Co. Proteine fusionnee a plusieurs variants d'il-3 et a activite hematopoietique
WO1995021197A1 (fr) * 1994-02-04 1995-08-10 G.D. Searle & Co. Proteine hybride variante de l'il-3 favorisant l'hematopoiese
WO1995027732A2 (fr) * 1994-04-08 1995-10-19 The Government Of The United States Of America, Represented By The Secretary Of The Department Of Health And Human Services Ligands et molecules chimeriques a permutation circulaire

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HORLICK, R.A. ET AL.: "Permuteins of interleukin 1beta ...", PROTEIN ENGINEERING, vol. 5, no. 5, 1992, pages 427 - 431, XP002022097 *

Also Published As

Publication number Publication date
AR010041A1 (es) 2000-05-17
AU725547B2 (en) 2000-10-12
AU5165298A (en) 1998-05-15
TW591035B (en) 2004-06-11
IL129565A0 (en) 2000-02-29
PL333023A1 (en) 1999-11-08
NO991948D0 (no) 1999-04-23
RO120919B1 (ro) 2006-09-29
EP0935663A2 (fr) 1999-08-18
NO991948L (no) 1999-06-23
BR9713668A (pt) 2000-03-08
CZ295843B6 (cs) 2005-11-16
TW200413407A (en) 2004-08-01
RU2005105360A (ru) 2006-08-10
RU2245887C2 (ru) 2005-02-10
CZ132399A3 (cs) 1999-12-15
ZA979607B (en) 1999-04-28
JP2001504689A (ja) 2001-04-10
NZ335382A (en) 2001-03-30
CA2268742A1 (fr) 1998-04-30
KR100497423B1 (ko) 2005-07-07
WO1998017810A2 (fr) 1998-04-30
KR20000052812A (ko) 2000-08-25

Similar Documents

Publication Publication Date Title
CA2200423A1 (fr) Nouveaux recepteurs d'oestrogene
ZA9711239B (en) OB fusion protein compositions and methods.
WO1998017810A3 (fr) Agonistes recepteurs hematopoietiques chimeriques multifonctionnels
AU3945197A (en) Novel stable liquid paracetamol compositions, and method for preparing same
WO1997012985A3 (fr) Agonistes multifonctionnels des recepteurs hematopoietiques
EP1117692A4 (fr) Anticorps agonistes de tie2
WO2000005367A3 (fr) Proteines humaines a domaines hydrophobes et adn codant pour ces proteines
IL132496A0 (en) Mammalian cytokine-like factor 7
EP0825260A3 (fr) Arginase II
WO2000015798A3 (fr) Facteur de croissance transformant beta - 9 mammaliens (ztgfss9)
WO2000029448A3 (fr) Proteines humaines a domaines hydrophobes et adn codant pour ces proteines
WO1998057983A3 (fr) Proteine de mammifere de type facteur de croissance nerveuse
AU4243097A (en) Mammalian chemokines, related reagents
AU1178100A (en) Novel g protein-coupled receptor protein, its dna and ligand thereof
AU2813297A (en) Mammalian mixed lymphocyte receptors, chemokine receptors {mmlr-ccr}
AU9512298A (en) Beta3-adrenoreceptor agonists, agonist compositions and methods of using
AU1952497A (en) Novel antibody-cytokine fusion protein, and methods of making and using the same
IL128500A0 (en) Substituted 1,2,3,4-tetrahydro-2-dibenzofuranamines and 2-aminocyclohepta (b) benzofurans
WO1999009182A3 (fr) Proteines rab
WO1998024896A3 (fr) Muteines de la proteine de l'obesite
AU5137698A (en) Novel dna, novel protein, and novel antibody
WO1999029720A3 (fr) Proteine 1 mammalienne a helice alpha
AU8552198A (en) 2-aryl-2,5-dihydro-pyrazolo{4,3-c}quinolin-3-ones as gaba alpha 5 receptor inverse agonists
WO1998057986A3 (fr) Preprotachykinine b humaine
WO1997000601A3 (fr) Polypeptides capables de liaison avec un recepteur de l'interleukine 8

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 97180892.9

Country of ref document: CN

AK Designated states

Kind code of ref document: A2

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW AM AZ BY KG KZ MD RU TJ TM

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH KE LS MW SD SZ UG ZW AT BE CH DE DK ES FI FR GB GR IE IT LU MC

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 51652/98

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: PV1999-1323

Country of ref document: CZ

ENP Entry into the national phase

Ref document number: 2268742

Country of ref document: CA

Ref document number: 2268742

Country of ref document: CA

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 1997946495

Country of ref document: EP

Ref document number: 335382

Country of ref document: NZ

ENP Entry into the national phase

Ref document number: 1998 519754

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: PA/a/1999/003877

Country of ref document: MX

Ref document number: 1019997003635

Country of ref document: KR

Ref document number: 99-00480

Country of ref document: RO

WWP Wipo information: published in national office

Ref document number: 1997946495

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: PV1999-1323

Country of ref document: CZ

WWP Wipo information: published in national office

Ref document number: 1019997003635

Country of ref document: KR

WWG Wipo information: grant in national office

Ref document number: 51652/98

Country of ref document: AU

WWG Wipo information: grant in national office

Ref document number: 1019997003635

Country of ref document: KR

WWG Wipo information: grant in national office

Ref document number: PV1999-1323

Country of ref document: CZ

WWW Wipo information: withdrawn in national office

Ref document number: 1997946495

Country of ref document: EP