ZA979607B - Multi-functional chimeric hematopoietic receptor agonists - Google Patents

Multi-functional chimeric hematopoietic receptor agonists

Info

Publication number
ZA979607B
ZA979607B ZA979607A ZA979607A ZA979607B ZA 979607 B ZA979607 B ZA 979607B ZA 979607 A ZA979607 A ZA 979607A ZA 979607 A ZA979607 A ZA 979607A ZA 979607 B ZA979607 B ZA 979607B
Authority
ZA
South Africa
Prior art keywords
receptor agonists
functional chimeric
hematopoietic receptor
chimeric hematopoietic
functional
Prior art date
Application number
ZA979607A
Other languages
English (en)
Inventor
Charles A Mcwherter
Yiqing Feng
John P Mckearn
Neena L Summers
Nicholas R Staten
Philip R Streeter
John C Minnerly
Nancy I Minster
Susan L Woulfe
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of ZA979607B publication Critical patent/ZA979607B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5403—IL-3
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
ZA979607A 1996-10-25 1997-10-27 Multi-functional chimeric hematopoietic receptor agonists ZA979607B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2962996P 1996-10-25 1996-10-25

Publications (1)

Publication Number Publication Date
ZA979607B true ZA979607B (en) 1999-04-28

Family

ID=21850035

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA979607A ZA979607B (en) 1996-10-25 1997-10-27 Multi-functional chimeric hematopoietic receptor agonists

Country Status (17)

Country Link
EP (1) EP0935663A2 (fr)
JP (1) JP2001504689A (fr)
KR (1) KR100497423B1 (fr)
AR (1) AR010041A1 (fr)
AU (1) AU725547B2 (fr)
BR (1) BR9713668A (fr)
CA (1) CA2268742A1 (fr)
CZ (1) CZ295843B6 (fr)
IL (1) IL129565A0 (fr)
NO (1) NO991948L (fr)
NZ (1) NZ335382A (fr)
PL (1) PL333023A1 (fr)
RO (1) RO120919B1 (fr)
RU (2) RU2245887C2 (fr)
TW (2) TW591035B (fr)
WO (1) WO1998017810A2 (fr)
ZA (1) ZA979607B (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5581476A (en) 1993-01-28 1996-12-03 Amgen Inc. Computer-based methods and articles of manufacture for preparing G-CSF analogs
US20020137890A1 (en) * 1997-03-31 2002-09-26 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
BR9808514A (pt) * 1997-04-11 2000-05-23 Searle & Co Proteìnas quiméricas do ligante flt3
BR9905867A (pt) * 1998-11-06 2001-01-23 Bio Sidus S A Linhagem celular produtora de eritropoietina humana recombinante e a eritropoietina humana recombinante produzida por esta célula
WO2002101047A1 (fr) * 2001-06-12 2002-12-19 Smithkline Beecham Corporation Procede d'identification de composes modulant les activites du gene 1 de reponse primaire a l'epo, eprg1
MXPA04000231A (es) 2001-07-11 2004-05-04 Maxygen Holdings Ltd Conjugados del factor de estimulacion de colonias de granulocitos.
WO2005047461A2 (fr) 2003-08-18 2005-05-26 The Regents Of The University Of California Bibliotheques d'affichage de polypeptides et procede de fabrication et d'utilisation de celle-ci
CA2607844C (fr) 2005-06-01 2012-07-10 Maxygen Holdings Ltd. Polypeptides g-csf pegyles et procedes de production correspondants
US7550433B2 (en) * 2005-06-03 2009-06-23 Affymax, Inc. Erythropoietin receptor peptide formulations and uses
WO2007027935A2 (fr) 2005-08-31 2007-03-08 The Regents Of The University Of California Bibliotheques cellulaires de sequences peptidiques (clips) et procedes d'utilisation de celles-ci
WO2007098548A1 (fr) * 2006-03-01 2007-09-07 Apollo Life Sciences Limited Molécule et chimères de cette molécule
WO2009014726A1 (fr) * 2007-07-26 2009-01-29 The Regents Of The University Of California Procédés permettant d'améliorer un affichage de cellules bactériennes de protéines et de peptides
US10071109B2 (en) 2013-11-06 2018-09-11 Molecular Templates, Inc. Predictive biomarker for hypoxia-activated prodrug therapy
EP3946409A4 (fr) * 2019-03-28 2023-06-21 Orionis Biosciences, Inc. Protéines chimériques basées sur le ligand de la tyrosine kinase-3 de type fms (flt3l)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2069746A1 (fr) * 1990-09-28 1992-03-29 Jonathan I. Rosen Facteurs de croissance heterogenes
US5376367A (en) * 1991-11-22 1994-12-27 Immunex Corporation Fusion proteins comprising MGF and IL-3
US5738849A (en) * 1992-11-24 1998-04-14 G. D. Searle & Co. Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them
US6057133A (en) * 1992-11-24 2000-05-02 G. D. Searle Multivariant human IL-3 fusion proteins and their recombinant production
US5635599A (en) * 1994-04-08 1997-06-03 The United States Of America As Represented By The Department Of Health And Human Services Fusion proteins comprising circularly permuted ligands

Also Published As

Publication number Publication date
AR010041A1 (es) 2000-05-17
AU725547B2 (en) 2000-10-12
AU5165298A (en) 1998-05-15
TW591035B (en) 2004-06-11
IL129565A0 (en) 2000-02-29
PL333023A1 (en) 1999-11-08
NO991948D0 (no) 1999-04-23
RO120919B1 (ro) 2006-09-29
EP0935663A2 (fr) 1999-08-18
NO991948L (no) 1999-06-23
BR9713668A (pt) 2000-03-08
CZ295843B6 (cs) 2005-11-16
TW200413407A (en) 2004-08-01
RU2005105360A (ru) 2006-08-10
RU2245887C2 (ru) 2005-02-10
CZ132399A3 (cs) 1999-12-15
JP2001504689A (ja) 2001-04-10
NZ335382A (en) 2001-03-30
CA2268742A1 (fr) 1998-04-30
WO1998017810A3 (fr) 1998-10-15
KR100497423B1 (ko) 2005-07-07
WO1998017810A2 (fr) 1998-04-30
KR20000052812A (ko) 2000-08-25

Similar Documents

Publication Publication Date Title
AU5203999A (en) Beta3-adrenergic receptor agonists
HK1021941A1 (en) Drinkable ibuprofen composition
GB2311707B (en) Echo canceller
IL129565A0 (en) Multi-functional chimeric hematopoietic receptor agonists
IL123832A0 (en) Multi-functional hematopoietic receptor antagonists
GB9617923D0 (en) Novel receptor
PL333203A1 (en) Multi-function liquid urethane composition
EP0960196A4 (fr) Nouveau recepteur provoquant la mort cellulaire
ZA9710576B (en) 2-imidazolinylaminoindazole compounds useful as alpha-2-adrenoceptor agonists
TW327367U (en) Document holder
EP0929561A4 (fr) Composition solide contenant du savon et des detergents synthetiques
IL121719A0 (en) Deicing composition
AU133665S (en) Facsimile transmitter-receiver
GB9414997D0 (en) Receptor cloning
TW340530U (en) Liquid materials feeder buffer
GB9717535D0 (en) Document holder
TW308945U (en) Multi-functional pen
AU131223S (en) Holder
GB9603849D0 (en) Muscarine agonists
AU131527S (en) Rod holder
AU131526S (en) Rod holder
AU131640S (en) Rod holder
AU131487S (en) Rod holder
AU127521S (en) Rod holder
GB9624566D0 (en) Rod holder