CA2267994C - Truncated platelet-activating factor acetylhydrolase - Google Patents

Truncated platelet-activating factor acetylhydrolase Download PDF

Info

Publication number
CA2267994C
CA2267994C CA002267994A CA2267994A CA2267994C CA 2267994 C CA2267994 C CA 2267994C CA 002267994 A CA002267994 A CA 002267994A CA 2267994 A CA2267994 A CA 2267994A CA 2267994 C CA2267994 C CA 2267994C
Authority
CA
Canada
Prior art keywords
paf
seq
activity
rph
leu
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002267994A
Other languages
English (en)
French (fr)
Other versions
CA2267994A1 (en
Inventor
Lawrence S. Cousens
Christine D. Eberhardt
Patrick Gray
Hai Le Trong
Larry W. Tjoelker
Cheryl L. Wilder
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Icos Corp
Original Assignee
Icos Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Icos Corp filed Critical Icos Corp
Publication of CA2267994A1 publication Critical patent/CA2267994A1/en
Application granted granted Critical
Publication of CA2267994C publication Critical patent/CA2267994C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/01—Carboxylic ester hydrolases (3.1.1)
    • C12Y301/01047—1-Alkyl-2-acetylglycerophosphocholine esterase (3.1.1.47), i.e. platelet-activating factor acetylhydrolase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Otolaryngology (AREA)
  • Neurosurgery (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA002267994A 1997-08-13 1997-08-13 Truncated platelet-activating factor acetylhydrolase Expired - Lifetime CA2267994C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1997/014212 WO1999009147A1 (en) 1997-08-13 1997-08-13 Truncated platelet-activating factor acetylhydrolase

Publications (2)

Publication Number Publication Date
CA2267994A1 CA2267994A1 (en) 1999-02-25
CA2267994C true CA2267994C (en) 2005-04-12

Family

ID=22261441

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002267994A Expired - Lifetime CA2267994C (en) 1997-08-13 1997-08-13 Truncated platelet-activating factor acetylhydrolase

Country Status (12)

Country Link
EP (1) EP0948605A1 (pt)
JP (1) JP2001502163A (pt)
AU (1) AU751594B2 (pt)
BR (1) BR9711882A (pt)
CA (1) CA2267994C (pt)
CZ (1) CZ297603B6 (pt)
HU (1) HUP9903959A3 (pt)
IL (3) IL129262A0 (pt)
NO (1) NO326968B1 (pt)
PL (1) PL190532B1 (pt)
SK (1) SK286518B6 (pt)
WO (1) WO1999009147A1 (pt)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112575057A (zh) * 2020-12-11 2021-03-30 深圳上泰生物工程有限公司 一种组合物及其在检测脂蛋白相关磷脂酶a2活性中的应用

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5981252A (en) 1993-06-25 1999-11-09 Smithkline Beecham Lipoprotein associated phospholipase A2, inhibitors thereof and use of the same in diagnosis and therapy
EP1294943A2 (en) * 2000-01-20 2003-03-26 Genome Therapeutics Corporation RAPID DETERMINATION OF GENE STRUCTURE USING cDNA SEQUENCE
CN103891709A (zh) * 2012-12-24 2014-07-02 深圳先进技术研究院 细胞冻存液及细胞冻存方法
WO2022120784A1 (zh) * 2020-12-11 2022-06-16 深圳上泰生物工程有限公司 一种组合物及其在检测脂蛋白相关磷脂酶a2活性中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5981252A (en) * 1993-06-25 1999-11-09 Smithkline Beecham Lipoprotein associated phospholipase A2, inhibitors thereof and use of the same in diagnosis and therapy
PT673426E (pt) * 1993-10-06 2001-11-30 Icos Corp Acetil-hidrolase do factor activador das plaquetas
EP0853673A1 (en) * 1995-09-29 1998-07-22 Smithkline Beecham Plc COMPOUND HAVING SEQUENCE HOMOLOGY WITH LIPOPROTEIN ASSOCIATED PHOSPHOLIPASE A2 (Lp-PLA2)/PAF ACETYL HYDROLASE
JP2002515728A (ja) * 1995-09-29 2002-05-28 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー 新規用途

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112575057A (zh) * 2020-12-11 2021-03-30 深圳上泰生物工程有限公司 一种组合物及其在检测脂蛋白相关磷脂酶a2活性中的应用
CN112575057B (zh) * 2020-12-11 2021-07-30 深圳上泰生物工程有限公司 一种组合物及其在检测脂蛋白相关磷脂酶a2活性中的应用

Also Published As

Publication number Publication date
AU3978297A (en) 1999-03-08
PL190532B1 (pl) 2005-12-30
JP2001502163A (ja) 2001-02-20
IL173867A0 (en) 2006-07-05
SK286518B6 (sk) 2008-12-05
AU751594B2 (en) 2002-08-22
WO1999009147A1 (en) 1999-02-25
HUP9903959A3 (en) 2002-01-28
EP0948605A1 (en) 1999-10-13
CZ124199A3 (cs) 2000-06-14
BR9711882A (pt) 1999-09-21
PL332833A1 (en) 1999-10-11
NO991717D0 (no) 1999-04-12
CA2267994A1 (en) 1999-02-25
NO326968B1 (no) 2009-03-23
IL129262A0 (en) 2000-02-17
HUP9903959A2 (hu) 2000-03-28
IL129262A (en) 2006-06-11
NO991717L (no) 1999-06-11
SK47399A3 (en) 2000-11-07
CZ297603B6 (cs) 2007-02-07

Similar Documents

Publication Publication Date Title
CA2151045C (en) Platelet-activating factor acetylhydrolase
US6797502B2 (en) 18891, a novel human lipase
US6045794A (en) Platelet-activating factor acetylhydrolase
US6203790B1 (en) Platelet-activating factor acetylhydrolase
CA2267994C (en) Truncated platelet-activating factor acetylhydrolase
US5847088A (en) Antibodies specific for platelet-activating factor acetylhydrolase
SK287687B6 (sk) Izolovaný polypeptid kódovaný génom podobným génu pre lipázu, prostriedok majúci fosfolipázovú účinnosť, farmaceutický prostriedok, antigénny fragment a izolovaná nukleová kyselina, biologicky aktívny prostriedok, vektor, rekombinovaná hostiteľská bunka, prostriedok využiteľný na transfekáciu cieľovej bunky, spôsob výroby polypeptidu a polypeptid takto vyrobený, protilátka, hybridomná bunka, spôsob in vitro sceeningu, spôsob in vitro enzymatickej hydrolýzy, použitie polypeptidu a protilátky a
US5656431A (en) Platelet-activating factor acetylhydrolase
JPH10504441A (ja) Ｔｎｆ形成阻害のための組成物およびその使用
RU2207875C2 (ru) Ускоренная ацетилгидролаза фактора активации тромбоцитов
KR20000068780A (ko) 절두된 혈소판-활성화 인자 아세틸히드롤라제
JP2009005705A (ja) 血小板活性化因子アセチルヒドロラーゼ
JPS6196998A (ja) ヒトアポリポプロテインａ−ｉ様蛋白の産生方法
US6586222B1 (en) Recombinant PR-3 and compositions thereof

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20170814