CA2263729C - Process for producing mammals with defined genetic properties - Google Patents
Process for producing mammals with defined genetic properties Download PDFInfo
- Publication number
- CA2263729C CA2263729C CA002263729A CA2263729A CA2263729C CA 2263729 C CA2263729 C CA 2263729C CA 002263729 A CA002263729 A CA 002263729A CA 2263729 A CA2263729 A CA 2263729A CA 2263729 C CA2263729 C CA 2263729C
- Authority
- CA
- Canada
- Prior art keywords
- cells
- mice
- blastocysts
- embryos
- process according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- 241000577979 Peromyscus spicilegus Species 0.000 description 1
- 108020004511 Recombinant DNA Proteins 0.000 description 1
- 101100351021 Xenopus laevis pax5 gene Proteins 0.000 description 1
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- DEFVIWRASFVYLL-UHFFFAOYSA-N ethylene glycol bis(2-aminoethyl)tetraacetic acid Chemical compound OC(=O)CN(CC(O)=O)CCOCCOCCN(CC(O)=O)CC(O)=O DEFVIWRASFVYLL-UHFFFAOYSA-N 0.000 description 1
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- 210000004185 liver Anatomy 0.000 description 1
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- 210000004962 mammalian cell Anatomy 0.000 description 1
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- 101150017984 mpr gene Proteins 0.000 description 1
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- 210000003101 oviduct Anatomy 0.000 description 1
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- 238000010561 standard procedure Methods 0.000 description 1
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000011816 wild-type C57Bl6 mouse Methods 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Environmental Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Engineering & Computer Science (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19632532.3 | 1996-08-13 | ||
| DE19632532A DE19632532A1 (de) | 1996-08-13 | 1996-08-13 | Verfahren zur Herstellung von Säugetieren mit definierten genetischen Eigenschaften |
| PCT/EP1997/004352 WO1998006834A1 (de) | 1996-08-13 | 1997-08-09 | Verfahren zur herstellung von säugetieren mit definierten genetischen eigenschaften |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2263729A1 CA2263729A1 (en) | 1998-02-19 |
| CA2263729C true CA2263729C (en) | 2006-06-27 |
Family
ID=7802466
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002263729A Expired - Lifetime CA2263729C (en) | 1996-08-13 | 1997-08-09 | Process for producing mammals with defined genetic properties |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6492575B1 (enExample) |
| EP (1) | EP0928332B1 (enExample) |
| JP (2) | JP2000516463A (enExample) |
| AT (1) | ATE281516T1 (enExample) |
| CA (1) | CA2263729C (enExample) |
| DE (2) | DE19632532A1 (enExample) |
| ES (1) | ES2231883T3 (enExample) |
| PT (1) | PT928332E (enExample) |
| WO (1) | WO1998006834A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5523226A (en) * | 1993-05-14 | 1996-06-04 | Biotechnology Research And Development Corp. | Transgenic swine compositions and methods |
| CN1083687C (zh) * | 1999-02-15 | 2002-05-01 | 湖南师范大学 | 四倍体鱼的培育方法 |
| CN1419413A (zh) * | 2000-03-28 | 2003-05-21 | 路德维格癌症研究所 | 表达血小板衍生生长因子c(pdgf－c)的非人转基因动物及其应用 |
| US6784336B2 (en) * | 2000-09-20 | 2004-08-31 | Whitehead Institute For Biomedical Research | Method of producing mutant mice |
| JP4087338B2 (ja) * | 2001-11-15 | 2008-05-21 | キリンファーマ株式会社 | キメラ非ヒト動物 |
| JP4364474B2 (ja) | 2002-02-15 | 2009-11-18 | 大学共同利用機関法人情報・システム研究機構 | 哺乳動物において機能的なトランスポゾン |
| US7365182B2 (en) * | 2002-05-01 | 2008-04-29 | Michigan State University | Plant vernalization independence (VIP) genes, proteins, and methods of use |
| GB0210539D0 (en) * | 2002-05-08 | 2002-06-19 | Univ Edinburgh | Control of es cell self renewal and lineage specification, and medium therefor |
| US7723565B2 (en) * | 2004-01-07 | 2010-05-25 | Wisconsin Alumni Research Foundation | Vernalization-related molecules and methods for inducibly-conferring epigenetic changes |
| EP2064325B1 (en) | 2006-09-01 | 2011-12-07 | Therapeutic Human Polyclonals, Inc. | Enhanced expression of human or humanized immunoglobulin in non-human transgenic animals |
| JP5624891B2 (ja) * | 2007-12-31 | 2014-11-12 | バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ | ヒト血液凝固因子を発現するトランスジェニック非ヒト動物 |
| US9587249B2 (en) | 2008-10-27 | 2017-03-07 | Baxalta GmbH | Models of thrombotic thrombocytopenic purpura and methods of use thereof |
| US20120178158A1 (en) * | 2009-06-23 | 2012-07-12 | The Scripps Research Institute | Adult animals generated from induced pluripotent cells |
| JP2013500743A (ja) | 2009-08-04 | 2013-01-10 | バクスター・インターナショナル・インコーポレイテッド | Ｆｖｉｉｉおよびｖｗｆがノックアウトされた遺伝子導入マウス−血友病ａモデル |
| US10662256B2 (en) | 2010-07-26 | 2020-05-26 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
| US10793829B2 (en) | 2010-07-26 | 2020-10-06 | Trianni, Inc. | Transgenic mammals and methods of use thereof |
| AU2011286185B2 (en) | 2010-07-26 | 2014-08-14 | Trianni, Inc. | Transgenic animals and methods of use |
| WO2015013575A2 (en) * | 2013-07-25 | 2015-01-29 | Ingenious Targeting Laboratory, Inc. | Knockout mice derived from site specific recombinase |
| EP3384030A4 (en) | 2015-12-03 | 2019-07-03 | Trianni, Inc. | IMPROVED IMMUNOGLULINIVITY |
| JP6929877B2 (ja) | 2016-02-04 | 2021-09-01 | トリアニ・インコーポレイテッドＴｒｉａｎｎｉ， Ｉｎｃ． | 免疫グロブリン産生の増強 |
| MA52431A (fr) * | 2018-03-02 | 2021-01-06 | Generation Bio Co | Identification et caractérisation de zones de sécurité du génome (gsh) chez les êtres humains et les génomes murins, et compositions de vecteurs viraux et non viraux pour une intégration ciblée au niveau d'un locus gsh identifié |
| JP7578306B2 (ja) * | 2020-03-06 | 2024-11-06 | 広州明訊生物科技有限公司 | 動物の製造方法 |
| WO2022235929A1 (en) | 2021-05-05 | 2022-11-10 | Radius Pharmaceuticals, Inc. | Animal model having homologous recombination of mouse pth1 receptor |
| CN115466718B (zh) * | 2022-08-09 | 2023-07-14 | 广州明迅生物科技有限责任公司 | 雌性胚胎干细胞及其制备方法和应用 |
| CN118185862B (zh) * | 2024-05-16 | 2024-08-09 | 中国科学院昆明动物研究所 | 一种小鼠四倍体器官的制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ244306A (en) * | 1991-09-30 | 1995-07-26 | Boehringer Ingelheim Int | Composition for introducing nucleic acid complexes into eucaryotic cells, complex containing nucleic acid and endosomolytic agent, peptide with endosomolytic domain and nucleic acid binding domain and preparation |
| DE4228162C1 (de) * | 1992-08-25 | 1994-01-13 | Rajewsky Klaus Dr | Verfahren zum Ersetzen homologer Genabschnitte aus Säugern in der Keimbahn von nicht-menschlichen Säugern |
| US5523226A (en) | 1993-05-14 | 1996-06-04 | Biotechnology Research And Development Corp. | Transgenic swine compositions and methods |
| US5907080A (en) * | 1995-11-30 | 1999-05-25 | Nexia Biotechnologies, Inc. | Method for development of transgenic dwarf goats |
| US6331406B1 (en) | 1997-03-31 | 2001-12-18 | The John Hopkins University School Of Medicine | Human enbryonic germ cell and methods of use |
-
1996
- 1996-08-13 DE DE19632532A patent/DE19632532A1/de not_active Withdrawn
-
1997
- 1997-08-09 AT AT97936698T patent/ATE281516T1/de active
- 1997-08-09 JP JP10509392A patent/JP2000516463A/ja not_active Withdrawn
- 1997-08-09 WO PCT/EP1997/004352 patent/WO1998006834A1/de not_active Ceased
- 1997-08-09 DE DE59712068T patent/DE59712068D1/de not_active Expired - Lifetime
- 1997-08-09 US US09/242,406 patent/US6492575B1/en not_active Expired - Lifetime
- 1997-08-09 PT PT97936698T patent/PT928332E/pt unknown
- 1997-08-09 EP EP97936698A patent/EP0928332B1/de not_active Expired - Lifetime
- 1997-08-09 CA CA002263729A patent/CA2263729C/en not_active Expired - Lifetime
- 1997-08-09 ES ES97936698T patent/ES2231883T3/es not_active Expired - Lifetime
-
2006
- 2006-08-10 JP JP2006218386A patent/JP4129472B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2231883T3 (es) | 2005-05-16 |
| US6492575B1 (en) | 2002-12-10 |
| ATE281516T1 (de) | 2004-11-15 |
| DE59712068D1 (de) | 2004-12-09 |
| CA2263729A1 (en) | 1998-02-19 |
| JP4129472B2 (ja) | 2008-08-06 |
| EP0928332A1 (de) | 1999-07-14 |
| EP0928332B1 (de) | 2004-11-03 |
| PT928332E (pt) | 2005-01-31 |
| JP2000516463A (ja) | 2000-12-12 |
| WO1998006834A1 (de) | 1998-02-19 |
| US20020178457A1 (en) | 2002-11-28 |
| JP2006296440A (ja) | 2006-11-02 |
| DE19632532A1 (de) | 1998-02-19 |
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