CA2252535C - A pharmaceutical formulation containing growth hormone, an amino acid and a non-ionic detergent - Google Patents
A pharmaceutical formulation containing growth hormone, an amino acid and a non-ionic detergent Download PDFInfo
- Publication number
- CA2252535C CA2252535C CA002252535A CA2252535A CA2252535C CA 2252535 C CA2252535 C CA 2252535C CA 002252535 A CA002252535 A CA 002252535A CA 2252535 A CA2252535 A CA 2252535A CA 2252535 C CA2252535 C CA 2252535C
- Authority
- CA
- Canada
- Prior art keywords
- growth hormone
- amino acid
- amount
- formulation
- histidine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Reproductive Health (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK0490/96 | 1996-04-24 | ||
| DK49096 | 1996-04-24 | ||
| PCT/DK1997/000184 WO1997039768A1 (en) | 1996-04-24 | 1997-04-24 | A pharmaceutical formulation containing growth hormone, an amino acid and a non-ionic detergent |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2252535A1 CA2252535A1 (en) | 1997-10-30 |
| CA2252535C true CA2252535C (en) | 2009-06-23 |
Family
ID=8094154
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002252535A Expired - Lifetime CA2252535C (en) | 1996-04-24 | 1997-04-24 | A pharmaceutical formulation containing growth hormone, an amino acid and a non-ionic detergent |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20020077461A1 (Direct) |
| EP (2) | EP0904099B1 (Direct) |
| JP (2) | JP4176834B2 (Direct) |
| KR (1) | KR20000010630A (Direct) |
| CN (1) | CN1130223C (Direct) |
| AT (1) | ATE309819T1 (Direct) |
| AU (1) | AU733592B2 (Direct) |
| BR (1) | BR9708858A (Direct) |
| CA (1) | CA2252535C (Direct) |
| CZ (1) | CZ298292B6 (Direct) |
| DE (1) | DE69734653T2 (Direct) |
| DK (1) | DK0904099T3 (Direct) |
| ES (1) | ES2253774T3 (Direct) |
| HU (1) | HU229868B1 (Direct) |
| IL (2) | IL126463A0 (Direct) |
| NO (1) | NO323360B1 (Direct) |
| PL (1) | PL188222B1 (Direct) |
| RU (1) | RU2236250C2 (Direct) |
| UA (1) | UA66758C2 (Direct) |
| WO (1) | WO1997039768A1 (Direct) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5981485A (en) | 1997-07-14 | 1999-11-09 | Genentech, Inc. | Human growth hormone aqueous formulation |
| CN1094757C (zh) | 1996-07-24 | 2002-11-27 | 沃尼尔·朗伯公司 | 用于治疗疼痛的异丁基γ－氨基丁酸及其衍生物 |
| ES2230727T3 (es) * | 1997-11-12 | 2005-05-01 | Alza Corporation | Procedimiento de administracion dermal de polipeptidos. |
| GB9803448D0 (en) * | 1998-02-18 | 1998-04-15 | Pharma Mar Sa | Pharmaceutical formulation |
| JP4711520B2 (ja) * | 2000-03-21 | 2011-06-29 | 日本ケミカルリサーチ株式会社 | 生理活性ペプチド含有粉末 |
| KR20030038690A (ko) | 2000-08-07 | 2003-05-16 | 인헤일 테라퓨틱 시스템즈 인크. | 응집이 최소화된, 흡입성 분무 건조 4-나선 다발 단백질분말 |
| CA2516314C (en) * | 2003-03-18 | 2012-01-03 | Ares Trading Sa | Liquid growth hormone formulation and process of preparation thereof |
| BRPI0408773A (pt) * | 2003-03-24 | 2006-03-28 | Biosphere Medical Inc | embolização temporária usando-se polìmeros termossensìveis inverso |
| DE10333317A1 (de) | 2003-07-22 | 2005-02-17 | Biotecon Therapeutics Gmbh | Formulierung für Proteinarzneimittel ohne Zusatz von humanem Serumalbumin (HSA) |
| WO2005046438A2 (en) * | 2003-11-06 | 2005-05-26 | Pluromed, Inc. | Internal clamp for surgical procedures |
| CA2551510C (en) * | 2003-12-23 | 2013-07-30 | Pharmacia Corporation | Stable growth hormone liquid formulation |
| ES2383994T3 (es) * | 2004-04-07 | 2012-06-28 | Ares Trading S.A. | Formulación líquida de hormona del crecimiento |
| CN103690936A (zh) * | 2004-12-22 | 2014-04-02 | Ambrx公司 | 经修饰的人类生长激素 |
| CN101090980A (zh) * | 2004-12-22 | 2007-12-19 | Ambrx公司 | 经修饰的人类生长激素 |
| US7816320B2 (en) * | 2004-12-22 | 2010-10-19 | Ambrx, Inc. | Formulations of human growth hormone comprising a non-naturally encoded amino acid at position 35 |
| CN101268098A (zh) | 2005-08-30 | 2008-09-17 | 诺沃-诺迪斯克保健股份有限公司 | 聚乙二醇化生长激素的液体制剂 |
| WO2007033427A1 (en) * | 2005-09-23 | 2007-03-29 | Metabolic Pharmaceuticals Limited | Stabilisation of peptides with basic amino acids |
| CN1939534B (zh) * | 2005-09-27 | 2010-12-01 | 长春金赛药业股份有限公司 | 含有人生长激素或人粒细胞巨噬细胞刺激因子的用于治疗损伤和溃疡的外用制剂 |
| US8409586B2 (en) | 2006-07-06 | 2013-04-02 | Daewoong Co., Ltd. | Stable liquid formulation of human growth hormone |
| US9175061B2 (en) | 2006-07-07 | 2015-11-03 | Novo Nordisk Health Care Ag | Protein conjugates and methods for their preparation |
| US8071544B2 (en) * | 2006-12-18 | 2011-12-06 | Althea Technologies, Inc. | Crystallized recombinant human growth factor formulations |
| KR101813595B1 (ko) | 2010-01-22 | 2017-12-29 | 노보 노르디스크 헬스 케어 악티엔게젤샤프트 | 장기적 생체 내 효능을 갖는 성장 호르몬 |
| US9211342B2 (en) | 2010-01-22 | 2015-12-15 | Novo Nordisk Healthcare Ag | Stable growth hormone compounds resistant to proteolytic degradation |
| KR101337797B1 (ko) * | 2010-07-14 | 2013-12-06 | 한미사이언스 주식회사 | 지속형 인간 성장 호르몬 결합체 액상 제제 |
| MX339605B (es) * | 2010-09-21 | 2016-06-02 | Ferring Bv | Proceso mejorado para produccion de la hormona de crecimiento humano recombinante. |
| US9216219B2 (en) | 2012-06-12 | 2015-12-22 | Novartis Ag | Anti-BAFFR antibody formulation |
| SG10201805807PA (en) | 2012-06-26 | 2018-08-30 | Del Mar Pharmaceuticals | Methods for treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or ahi1 dysregulations or mutations employing dianhydrogalactitol, diacetyldianhydrogalactitol, dibromodulcitol, or analogs or derivatives thereof |
| US11045523B2 (en) | 2013-04-05 | 2021-06-29 | Novo Nordisk Healthcare Ag | Formulation of growth hormone albumin-binder conjugate |
| EP2983674A4 (en) | 2013-04-08 | 2017-05-10 | Dennis M. Brown | Therapeutic benefit of suboptimally administered chemical compounds |
| AU2014293011A1 (en) | 2013-07-26 | 2016-03-17 | Race Oncology Ltd. | Compositions to improve the therapeutic benefit of bisantrene |
| RU2683823C2 (ru) * | 2013-09-27 | 2019-04-02 | Ханми Фарм. Ко., Лтд. | Препарат гормона роста человека длительного типа |
| US9119832B2 (en) | 2014-02-05 | 2015-09-01 | The Regents Of The University Of California | Methods of treating mild brain injury |
| WO2017075535A1 (en) | 2015-10-28 | 2017-05-04 | Oxeia Biopharmaceuticals, Inc. | Methods of treating neurodegenerative conditions |
| EP4321513A3 (en) | 2016-03-28 | 2024-05-08 | Incyte Corporation | Pyrrolotriazine compounds as tam inhibitors |
| EP3679945A4 (en) | 2017-09-07 | 2021-06-16 | JCR Pharmaceuticals Co., Ltd. | Aqueous PHARMACEUTICAL COMPOSITION |
| AU2018342471B2 (en) | 2017-09-27 | 2023-08-24 | Incyte Corporation | Salts of pyrrolotriazine derivatives useful as TAM inhibitors |
| DK3813800T3 (da) | 2018-06-29 | 2025-06-02 | Incyte Corp | Formuleringer af en axl/mer-hæmmer |
| AU2021230385A1 (en) | 2020-03-06 | 2022-09-22 | Incyte Corporation | Combination therapy comprising AXL/MER and PD-1/PD-L1 inhibitors |
| CN115634284B (zh) * | 2022-10-31 | 2025-02-11 | 景泽生物医药(合肥)股份有限公司 | 一种促性腺激素冻干制剂及其制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5096885A (en) * | 1988-04-15 | 1992-03-17 | Genentech, Inc. | Human growth hormone formulation |
| DK204791D0 (da) * | 1991-12-20 | 1991-12-20 | Novo Nordisk As | Hidtil ukendt farmaceutisk praeparat |
| CZ283361B6 (cs) * | 1991-12-20 | 1998-03-18 | Novo Nordisk A/S | Farmaceutický přípravek obsahující růstový hormon a histidin |
| DE69329651T3 (de) * | 1992-07-31 | 2008-10-30 | Genentech, Inc., South San Francisco | Wässrige arzneizusammensetzung, welche das menschliche wachstumshormon enthält |
-
1997
- 1997-04-23 US US08/842,293 patent/US20020077461A1/en not_active Abandoned
- 1997-04-24 CZ CZ0320798A patent/CZ298292B6/cs not_active IP Right Cessation
- 1997-04-24 EP EP97918073A patent/EP0904099B1/en not_active Expired - Lifetime
- 1997-04-24 EP EP05110701A patent/EP1629832A1/en not_active Withdrawn
- 1997-04-24 DK DK97918073T patent/DK0904099T3/da active
- 1997-04-24 DE DE69734653T patent/DE69734653T2/de not_active Expired - Lifetime
- 1997-04-24 WO PCT/DK1997/000184 patent/WO1997039768A1/en not_active Ceased
- 1997-04-24 JP JP53762297A patent/JP4176834B2/ja not_active Expired - Lifetime
- 1997-04-24 AU AU26343/97A patent/AU733592B2/en not_active Expired
- 1997-04-24 CA CA002252535A patent/CA2252535C/en not_active Expired - Lifetime
- 1997-04-24 HU HU9902476A patent/HU229868B1/hu unknown
- 1997-04-24 PL PL97329386A patent/PL188222B1/pl unknown
- 1997-04-24 BR BR9708858A patent/BR9708858A/pt not_active Application Discontinuation
- 1997-04-24 AT AT97918073T patent/ATE309819T1/de active
- 1997-04-24 RU RU98121135/15A patent/RU2236250C2/ru active
- 1997-04-24 KR KR1019980708535A patent/KR20000010630A/ko not_active Ceased
- 1997-04-24 ES ES97918073T patent/ES2253774T3/es not_active Expired - Lifetime
- 1997-04-24 IL IL12646397A patent/IL126463A0/xx active IP Right Grant
- 1997-04-24 CN CN97194040A patent/CN1130223C/zh not_active Expired - Lifetime
- 1997-04-24 UA UA98105593A patent/UA66758C2/xx unknown
-
1998
- 1998-10-04 IL IL126463A patent/IL126463A/en not_active IP Right Cessation
- 1998-10-23 NO NO19984951A patent/NO323360B1/no not_active IP Right Cessation
-
2008
- 2008-06-03 JP JP2008145780A patent/JP2008231124A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| ES2253774T3 (es) | 2006-06-01 |
| PL188222B1 (pl) | 2004-12-31 |
| NO984951L (no) | 1998-10-23 |
| UA66758C2 (en) | 2004-06-15 |
| JP4176834B2 (ja) | 2008-11-05 |
| NO323360B1 (no) | 2007-04-10 |
| CZ298292B6 (cs) | 2007-08-15 |
| AU2634397A (en) | 1997-11-12 |
| CN1216472A (zh) | 1999-05-12 |
| KR20000010630A (ko) | 2000-02-25 |
| CN1130223C (zh) | 2003-12-10 |
| DE69734653T2 (de) | 2006-08-10 |
| BR9708858A (pt) | 1999-08-03 |
| AU733592B2 (en) | 2001-05-17 |
| DE69734653D1 (de) | 2005-12-22 |
| IL126463A (en) | 2007-06-17 |
| US20020077461A1 (en) | 2002-06-20 |
| WO1997039768A1 (en) | 1997-10-30 |
| IL126463A0 (en) | 1999-08-17 |
| JP2000508665A (ja) | 2000-07-11 |
| CA2252535A1 (en) | 1997-10-30 |
| ATE309819T1 (de) | 2005-12-15 |
| EP0904099B1 (en) | 2005-11-16 |
| RU2236250C2 (ru) | 2004-09-20 |
| HU229868B1 (en) | 2014-10-28 |
| CZ320798A3 (cs) | 1999-03-17 |
| EP0904099A1 (en) | 1999-03-31 |
| JP2008231124A (ja) | 2008-10-02 |
| HUP9902476A2 (hu) | 2000-11-28 |
| NO984951D0 (no) | 1998-10-23 |
| PL329386A1 (en) | 1999-03-29 |
| DK0904099T3 (da) | 2006-03-06 |
| HUP9902476A3 (en) | 2000-12-28 |
| EP1629832A1 (en) | 2006-03-01 |
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Legal Events
| Date | Code | Title | Description |
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| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20170424 |
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| MKEX | Expiry |
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