CA2246783C - Mcbi analogs of cc-1065 and the duocarmycins - Google Patents

Mcbi analogs of cc-1065 and the duocarmycins Download PDF

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Publication number
CA2246783C
CA2246783C CA002246783A CA2246783A CA2246783C CA 2246783 C CA2246783 C CA 2246783C CA 002246783 A CA002246783 A CA 002246783A CA 2246783 A CA2246783 A CA 2246783A CA 2246783 C CA2246783 C CA 2246783C
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CA
Canada
Prior art keywords
mcbi
compound
dna
hours
represented
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002246783A
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English (en)
French (fr)
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CA2246783A1 (en
Inventor
Dale L. Boger
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Scripps Research Institute
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Scripps Research Institute
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Application filed by Scripps Research Institute filed Critical Scripps Research Institute
Publication of CA2246783A1 publication Critical patent/CA2246783A1/en
Application granted granted Critical
Publication of CA2246783C publication Critical patent/CA2246783C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Auxiliary Devices For And Details Of Packaging Control (AREA)
  • Dc Digital Transmission (AREA)
  • Silicon Polymers (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Electrotherapy Devices (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
CA002246783A 1996-03-08 1997-03-07 Mcbi analogs of cc-1065 and the duocarmycins Expired - Fee Related CA2246783C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1302496P 1996-03-08 1996-03-08
US60/013,024 1996-03-08
PCT/US1997/003641 WO1997032850A1 (en) 1996-03-08 1997-03-07 Mcbi analogs of cc-1065 and the duocarmycins

Publications (2)

Publication Number Publication Date
CA2246783A1 CA2246783A1 (en) 1997-09-12
CA2246783C true CA2246783C (en) 2006-07-11

Family

ID=21757922

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002246783A Expired - Fee Related CA2246783C (en) 1996-03-08 1997-03-07 Mcbi analogs of cc-1065 and the duocarmycins

Country Status (9)

Country Link
US (1) US5985908A (cg-RX-API-DMAC10.html)
EP (1) EP0888301B1 (cg-RX-API-DMAC10.html)
JP (1) JP2000506168A (cg-RX-API-DMAC10.html)
AT (1) ATE301639T1 (cg-RX-API-DMAC10.html)
AU (1) AU711974B2 (cg-RX-API-DMAC10.html)
CA (1) CA2246783C (cg-RX-API-DMAC10.html)
DE (1) DE69733942T2 (cg-RX-API-DMAC10.html)
ES (1) ES2244991T3 (cg-RX-API-DMAC10.html)
WO (1) WO1997032850A1 (cg-RX-API-DMAC10.html)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6060608A (en) * 1996-05-31 2000-05-09 The Scripps Research Institute Analogs of CC-1065 and the duocarmycins
WO1998011101A2 (en) * 1996-09-12 1998-03-19 Cancer Research Campaign Technology Limited Condensed n-aclyindoles as antitumor agents
US6130237A (en) * 1996-09-12 2000-10-10 Cancer Research Campaign Technology Limited Condensed N-aclyindoles as antitumor agents
WO1998025900A1 (en) * 1996-12-13 1998-06-18 Shionogi & Co., Ltd. Compounds having antitumor activity
JP3649617B2 (ja) * 1999-03-26 2005-05-18 独立行政法人科学技術振興機構 ２本鎖ｄｎａを切断できる化合物及びその使用方法
JP5010089B2 (ja) * 2000-09-19 2012-08-29 スピロジェン リミテッド Ｃｃ−１０６５およびデュオカルマイシンのアキラルアナログの組成物およびその使用方法
DE60211905T2 (de) * 2001-02-22 2007-01-18 School Of Pharmacy, University Of London Benz-indol- und benzo-chinolin-derivate als prodrugs zur tumorbehandlung
EP1409480B1 (en) 2001-02-22 2007-11-14 The School Of Pharmacy, University Of London Pyrrolo-indole and pyrrolo-quinoline derivatives as prodrugs for tumour treatment
MXPA03011094A (es) 2001-05-31 2004-12-06 Medarex Inc Citotoxinas, profarmacos, ligadores, y estabilizadores utiles para ello.
AU2003287160A1 (en) * 2002-10-15 2004-05-04 Rigel Pharmaceuticals, Inc. Substituted indoles and their use as hcv inhibitors
JPWO2005087762A1 (ja) 2004-03-13 2008-01-24 テムリック株式会社 Ｄｎａの特定塩基配列をアルキル化する新規インドール誘導体ならびにそれを用いたアルキル化剤および薬剤
CA2564076C (en) 2004-05-19 2014-02-18 Medarex, Inc. Chemical linkers and conjugates thereof
RU2402548C2 (ru) 2004-05-19 2010-10-27 Медарекс, Инк. Химические линкеры и их конъюгаты
US7714016B2 (en) 2005-04-08 2010-05-11 Medarex, Inc. Cytotoxic compounds and conjugates with cleavable substrates
WO2007051081A1 (en) * 2005-10-26 2007-05-03 Medarex, Inc. Methods and compounds for preparing cc-1065 analogs
WO2007059404A2 (en) 2005-11-10 2007-05-24 Medarex, Inc. Duocarmycin derivatives as novel cytotoxic compounds and conjugates
TWI412367B (zh) 2006-12-28 2013-10-21 Medarex Llc 化學鏈接劑與可裂解基質以及其之綴合物
WO2008103693A2 (en) 2007-02-21 2008-08-28 Medarex, Inc. Chemical linkers with single amino acids and conjugates thereof
US9901567B2 (en) 2007-08-01 2018-02-27 Syntarga B.V. Substituted CC-1065 analogs and their conjugates
AU2009320481C1 (en) 2008-11-03 2016-12-08 Syntarga B.V. Novel CC-1065 analogs and their conjugates
WO2011133039A2 (en) 2010-04-21 2011-10-27 Syntarga B.V. Novel conjugates of cc-1065 analogs and bifunctional linkers
EP2762472B1 (en) * 2011-09-28 2017-05-24 Industry-Academia Cooperation Group of Sejong University Selenophene-fused aromatic compound and manufacturing method thereof
ES2701076T3 (es) 2012-11-24 2019-02-20 Hangzhou Dac Biotech Co Ltd Enlazadores hidrofílicos y sus usos para la conjugación de fármacos a las moléculas que se unen a las células
CN105102455B (zh) 2012-12-21 2018-05-25 荷商台医(有限合伙)公司 亲水性自消耗连接子及其缀合物
MY177390A (en) 2014-01-10 2020-09-14 Byondis Bv Method for purifying cys-linked antibody-drug conjugates
FI3122757T3 (fi) 2014-02-28 2023-10-10 Hangzhou Dac Biotech Co Ltd Varautuneita linkkereitä ja niiden konjugointikäyttötapoja
SG11201610620UA (en) 2014-06-20 2017-01-27 Bioalliance Cv Anti-folate receptor aplha (fra) antibody-drug conjugates and methods of using thereof
EP4678240A2 (en) 2015-07-12 2026-01-14 Hangzhou Dac Biotech Co., Ltd. Bridge linkers for conjugation of cell-binding molecules
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
ES2880731T3 (es) 2016-01-08 2021-11-25 Altrubio Inc Anticuerpos anti-PSGL-1 tetravalentes y usos de los mismos
MX2019005583A (es) 2016-11-14 2019-10-21 Hangzhou Dac Biotech Co Ltd Vinculantes de conjugacion, conjugados de molecula de union a celulas que contienen los vinculantes, metodos de creacion y usos de dichos conjugados con los vinculantes.
KR102894542B1 (ko) 2020-01-30 2025-12-03 (주)에임드바이오 벤조셀레노펜계 화합물, 이를 포함하는 약학적 조성물 및 항체-약물 결합체
KR20240095442A (ko) 2021-11-03 2024-06-25 항저우 디에이씨 바이오테크 씨오, 엘티디 항체의 특이적 접합

Also Published As

Publication number Publication date
AU1990297A (en) 1997-09-22
EP0888301A1 (en) 1999-01-07
DE69733942D1 (de) 2005-09-15
WO1997032850A1 (en) 1997-09-12
DE69733942T2 (de) 2006-06-08
US5985908A (en) 1999-11-16
EP0888301B1 (en) 2005-08-10
CA2246783A1 (en) 1997-09-12
AU711974B2 (en) 1999-10-28
ES2244991T3 (es) 2005-12-16
JP2000506168A (ja) 2000-05-23
ATE301639T1 (de) 2005-08-15
EP0888301A4 (en) 2002-05-08

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