CA2235126A1 - Derives quinolines en tant qu'inhibiteurs des phosphodiesterases de type iv - Google Patents
Derives quinolines en tant qu'inhibiteurs des phosphodiesterases de type iv Download PDFInfo
- Publication number
- CA2235126A1 CA2235126A1 CA002235126A CA2235126A CA2235126A1 CA 2235126 A1 CA2235126 A1 CA 2235126A1 CA 002235126 A CA002235126 A CA 002235126A CA 2235126 A CA2235126 A CA 2235126A CA 2235126 A1 CA2235126 A1 CA 2235126A1
- Authority
- CA
- Canada
- Prior art keywords
- benzo
- quinoline
- methyl
- treatment
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pulmonology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Des quinolines substituées en position 8 par benzo(c)thiadiazolyle, benzo(c)furazanyle, ou 2-méthyl-2H-benzo(d)triazolyle, sous forme libre ou de N-oxyde ou d'un sel d'addition d'acide ou d'ammonium, sont nouvelles et se sont avérées utiles en tant que produits pharmaceutiques, par exemple en tant qu'inhibiteurs des phosphodiestérases de type IV, notamment dans le traitement de l'asthme. On décrit également des nouvelles méthodes de traitement dans lesquelles on utilise ces composés, des procédés de fabrication de ceux-ci et des compositions pharmaceutiques comprenant ces composés. A titre d'exemple, on décrit des composés répondant à la formule (1) dans laquelle X représente -O-, -S- ou -N(CH¿3?)-, R¿1? représente hydrogène ou alkyle C¿1-4? et R¿2? représente alkyle C¿1-4? ou pyridyle, ces composés étant sous forme libre ou de N-oxyde ou d'un sel d'addition d'acide ou d'ammonium, acceptable sur le plan pharmacologique.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9523267.4 | 1995-11-14 | ||
GBGB9523267.4A GB9523267D0 (en) | 1995-11-14 | 1995-11-14 | Organic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2235126A1 true CA2235126A1 (fr) | 1997-05-22 |
Family
ID=10783856
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002235126A Abandoned CA2235126A1 (fr) | 1995-11-14 | 1996-11-13 | Derives quinolines en tant qu'inhibiteurs des phosphodiesterases de type iv |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP0873338A1 (fr) |
JP (1) | JPH11515000A (fr) |
KR (1) | KR19990067574A (fr) |
CN (1) | CN1202170A (fr) |
AU (1) | AU7570996A (fr) |
BR (1) | BR9611504A (fr) |
CA (1) | CA2235126A1 (fr) |
CO (1) | CO4770973A1 (fr) |
CZ (1) | CZ149498A3 (fr) |
GB (1) | GB9523267D0 (fr) |
HU (1) | HUP9903492A3 (fr) |
MX (1) | MX9803839A (fr) |
PE (1) | PE17598A1 (fr) |
PL (1) | PL326636A1 (fr) |
SK (1) | SK63998A3 (fr) |
TR (1) | TR199800851T2 (fr) |
WO (1) | WO1997018208A1 (fr) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100701904B1 (ko) | 1999-08-21 | 2007-04-02 | 알타나 파마 아게 | Pde 억제제 및 베타 2 아드레날린수용체 작동제의상승적 조합 |
CN1520313A (zh) | 2001-05-23 | 2004-08-11 | ������ҩ��ʽ���� | 一种加速骨折愈合的组合物 |
CA2447618A1 (fr) | 2001-05-23 | 2002-11-28 | Tanabe Seiyaku Co., Ltd. | Composition pour le traitement regeneratif de la maladie du cartilage |
TW200536851A (en) * | 2004-01-23 | 2005-11-16 | Amgen Inc | Compounds and methods of use |
JP2006347936A (ja) * | 2005-06-15 | 2006-12-28 | Bayer Cropscience Ag | 殺虫性ベンズアニリド類 |
AR081377A1 (es) | 2010-05-10 | 2012-08-29 | Gilead Sciences Inc | Compuestos de pirazolopiridina bifuncionales |
EP2569285A1 (fr) | 2010-05-10 | 2013-03-20 | Gilead Sciences, Inc. | Dérivés quinoliniques bifonctionnels |
AR093017A1 (es) | 2012-10-16 | 2015-05-13 | Janssen Pharmaceutica Nv | MODULARES DE RORgT DE QUINOLINILO UNIDOS POR METILENO |
JP6250686B2 (ja) | 2012-10-16 | 2017-12-20 | ヤンセン ファーマシューティカ エヌ.ベー. | Rorγtのヘテロアリール結合させたキノリニルモジュレータ |
JP6251277B2 (ja) | 2012-10-16 | 2017-12-20 | ヤンセン ファーマシューティカ エヌ.ベー. | ROR−ガンマ−tのフェニル結合キノリニルモジュレーター |
US10555941B2 (en) | 2013-10-15 | 2020-02-11 | Janssen Pharmaceutica Nv | Alkyl linked quinolinyl modulators of RORγt |
ES2770727T3 (es) | 2013-10-15 | 2020-07-02 | Janssen Pharmaceutica Nv | Moduladores de quinilonila enlazados a alquilo de ROR(gamma)t |
US9328095B2 (en) | 2013-10-15 | 2016-05-03 | Janssen Pharmaceutica Nv | Heteroaryl linked quinolinyl modulators of RORgammat |
US9284308B2 (en) | 2013-10-15 | 2016-03-15 | Janssen Pharmaceutica Nv | Methylene linked quinolinyl modulators of RORγt |
US9221804B2 (en) | 2013-10-15 | 2015-12-29 | Janssen Pharmaceutica Nv | Secondary alcohol quinolinyl modulators of RORγt |
US9403816B2 (en) | 2013-10-15 | 2016-08-02 | Janssen Pharmaceutica Nv | Phenyl linked quinolinyl modulators of RORγt |
US9624225B2 (en) | 2013-10-15 | 2017-04-18 | Janssen Pharmaceutica Nv | Quinolinyl modulators of RORγt |
EP3813532B1 (fr) * | 2018-06-24 | 2024-02-28 | Adama Agan Ltd. | Procédé de préparation de quinmérac |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9027055D0 (en) * | 1990-12-13 | 1991-02-06 | Sandoz Ltd | Organic compounds |
US5455252A (en) * | 1993-03-31 | 1995-10-03 | Syntex (U.S.A.) Inc. | Optionally substituted 6,8-quinolines |
-
1995
- 1995-11-14 GB GBGB9523267.4A patent/GB9523267D0/en active Pending
-
1996
- 1996-11-12 PE PE1996000810A patent/PE17598A1/es not_active Application Discontinuation
- 1996-11-13 CO CO96059775A patent/CO4770973A1/es unknown
- 1996-11-13 SK SK639-98A patent/SK63998A3/sk unknown
- 1996-11-13 BR BR9611504A patent/BR9611504A/pt not_active Application Discontinuation
- 1996-11-13 AU AU75709/96A patent/AU7570996A/en not_active Abandoned
- 1996-11-13 WO PCT/EP1996/004978 patent/WO1997018208A1/fr not_active Application Discontinuation
- 1996-11-13 CZ CZ981494A patent/CZ149498A3/cs unknown
- 1996-11-13 EP EP96938196A patent/EP0873338A1/fr not_active Withdrawn
- 1996-11-13 KR KR1019980703597A patent/KR19990067574A/ko not_active Application Discontinuation
- 1996-11-13 CN CN96198305A patent/CN1202170A/zh active Pending
- 1996-11-13 PL PL96326636A patent/PL326636A1/xx unknown
- 1996-11-13 CA CA002235126A patent/CA2235126A1/fr not_active Abandoned
- 1996-11-13 HU HU9903492A patent/HUP9903492A3/hu unknown
- 1996-11-13 JP JP9515313A patent/JPH11515000A/ja not_active Withdrawn
- 1996-11-13 TR TR1998/00851T patent/TR199800851T2/xx unknown
-
1998
- 1998-05-14 MX MX9803839A patent/MX9803839A/es unknown
Also Published As
Publication number | Publication date |
---|---|
MX9803839A (es) | 1998-09-30 |
KR19990067574A (ko) | 1999-08-25 |
CZ149498A3 (cs) | 1998-08-12 |
GB9523267D0 (en) | 1996-01-17 |
WO1997018208A1 (fr) | 1997-05-22 |
AU7570996A (en) | 1997-06-05 |
CO4770973A1 (es) | 1999-04-30 |
SK63998A3 (en) | 1998-10-07 |
HUP9903492A3 (en) | 2000-08-28 |
PL326636A1 (en) | 1998-10-12 |
EP0873338A1 (fr) | 1998-10-28 |
CN1202170A (zh) | 1998-12-16 |
PE17598A1 (es) | 1998-04-06 |
TR199800851T2 (xx) | 1998-08-21 |
JPH11515000A (ja) | 1999-12-21 |
BR9611504A (pt) | 1999-03-02 |
HUP9903492A2 (en) | 2000-07-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued |