CA2234061A1 - Multi-functional hematopoietic receptor agonists - Google Patents
Multi-functional hematopoietic receptor agonists Download PDFInfo
- Publication number
- CA2234061A1 CA2234061A1 CA002234061A CA2234061A CA2234061A1 CA 2234061 A1 CA2234061 A1 CA 2234061A1 CA 002234061 A CA002234061 A CA 002234061A CA 2234061 A CA2234061 A CA 2234061A CA 2234061 A1 CA2234061 A1 CA 2234061A1
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- Prior art keywords
- leu
- xaa
- ala
- ser
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- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/524—Thrombopoietin, i.e. C-MPL ligand
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5403—IL-3
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US483495P | 1995-10-05 | 1995-10-05 | |
| US60/004,834 | 1995-10-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2234061A1 true CA2234061A1 (en) | 1997-04-10 |
Family
ID=21712756
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002234061A Abandoned CA2234061A1 (en) | 1995-10-05 | 1996-10-04 | Multi-functional hematopoietic receptor agonists |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0854928A2 (cs) |
| JP (1) | JPH11510062A (cs) |
| KR (1) | KR100456212B1 (cs) |
| CN (2) | CN1124348C (cs) |
| AU (1) | AU705083B2 (cs) |
| BR (1) | BRPI9610977A2 (cs) |
| CA (1) | CA2234061A1 (cs) |
| CZ (1) | CZ295518B6 (cs) |
| IL (1) | IL123832A0 (cs) |
| MX (1) | MX9802730A (cs) |
| NO (1) | NO981500L (cs) |
| NZ (1) | NZ320978A (cs) |
| PL (1) | PL184424B1 (cs) |
| WO (1) | WO1997012985A2 (cs) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5581476A (en) | 1993-01-28 | 1996-12-03 | Amgen Inc. | Computer-based methods and articles of manufacture for preparing G-CSF analogs |
| US5969105A (en) * | 1996-10-25 | 1999-10-19 | Feng; Yiqing | Stem cell factor receptor agonists |
| US6967092B1 (en) | 1996-10-25 | 2005-11-22 | Mc Kearn John P | Multi-functional chimeric hematopoietic receptor agonists |
| US6660257B1 (en) * | 1996-10-25 | 2003-12-09 | Pharmacia Corporation | Circular permuteins of flt3 ligand |
| US6187564B1 (en) | 1997-07-10 | 2001-02-13 | Beth Israel Deaconess Medical Center | DNA encoding erythropoietin multimers having modified 5′ and 3′ sequences and its use to prepare EPO therapeutics |
| US6242570B1 (en) | 1997-07-10 | 2001-06-05 | Beth Israel Deaconess Medical Center | Production and use of recombinant protein multimers with increased biological activity |
| US6165476A (en) * | 1997-07-10 | 2000-12-26 | Beth Israel Deaconess Medical Center | Fusion proteins with an immunoglobulin hinge region linker |
| AU7825500A (en) * | 1999-10-07 | 2001-04-23 | Pharmacia Corporation | Inhibition enzyme linked immunosorbent assay (iELISA) for the detection and quantification of antibodies in biological samples |
| ATE468862T1 (de) | 2001-07-11 | 2010-06-15 | Maxygen Inc | G-csf konjugate |
| ATE500847T1 (de) | 2005-06-01 | 2011-03-15 | Maxygen Inc | Pegylierte g-csf-polypeptide und herstellungsverfahren dafür |
| WO2007075899A2 (en) * | 2005-12-21 | 2007-07-05 | Maxygen, Inc. | Dual agonist compounds and uses thereof |
| CN102675472B (zh) * | 2012-05-07 | 2014-07-30 | 北京诺派生物科技有限公司 | 用于检测猪繁殖与呼吸综合症患猪的试剂盒 |
| US9763984B2 (en) | 2012-12-21 | 2017-09-19 | Astellas Institute For Regenerative Medicine | Methods for production of platelets from pluripotent stem cells and compositions thereof |
| LT6161B (lt) | 2013-09-27 | 2015-06-25 | Uab Profarma | Granuliocitų kolonijas stimuliuojančio faktoriaus sulieti baltymai su kitais augimo faktoriais, optimaliai su kamieninių ląstelių faktoriumi, ir jų gavimo būdas |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990012877A1 (en) * | 1989-04-19 | 1990-11-01 | Cetus Corporation | Multifunctional m-csf proteins and genes encoding therefor |
| US5738849A (en) * | 1992-11-24 | 1998-04-14 | G. D. Searle & Co. | Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them |
| US6057133A (en) * | 1992-11-24 | 2000-05-02 | G. D. Searle | Multivariant human IL-3 fusion proteins and their recombinant production |
| US5635599A (en) * | 1994-04-08 | 1997-06-03 | The United States Of America As Represented By The Department Of Health And Human Services | Fusion proteins comprising circularly permuted ligands |
-
1996
- 1996-10-04 WO PCT/US1996/015774 patent/WO1997012985A2/en not_active Application Discontinuation
- 1996-10-04 NZ NZ320978A patent/NZ320978A/en unknown
- 1996-10-04 PL PL96326072A patent/PL184424B1/pl not_active IP Right Cessation
- 1996-10-04 CZ CZ1998965A patent/CZ295518B6/cs not_active IP Right Cessation
- 1996-10-04 AU AU73844/96A patent/AU705083B2/en not_active Ceased
- 1996-10-04 CN CN96198815A patent/CN1124348C/zh not_active Expired - Fee Related
- 1996-10-04 EP EP96936114A patent/EP0854928A2/en not_active Withdrawn
- 1996-10-04 CN CNA031551432A patent/CN1590407A/zh active Pending
- 1996-10-04 JP JP9514385A patent/JPH11510062A/ja not_active Abandoned
- 1996-10-04 KR KR10-1998-0702547A patent/KR100456212B1/ko not_active Expired - Fee Related
- 1996-10-04 CA CA002234061A patent/CA2234061A1/en not_active Abandoned
- 1996-10-04 BR BRPI9610977A patent/BRPI9610977A2/pt not_active IP Right Cessation
- 1996-10-04 IL IL12383296A patent/IL123832A0/xx unknown
-
1998
- 1998-04-02 NO NO981500A patent/NO981500L/no not_active Application Discontinuation
- 1998-04-06 MX MX9802730A patent/MX9802730A/es not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO1997012985A3 (en) | 1997-08-07 |
| CN1204369A (zh) | 1999-01-06 |
| CN1590407A (zh) | 2005-03-09 |
| AU705083B2 (en) | 1999-05-13 |
| IL123832A0 (en) | 1998-10-30 |
| MX9802730A (es) | 1998-09-30 |
| PL184424B1 (pl) | 2002-10-31 |
| PL326072A1 (en) | 1998-08-17 |
| CN1124348C (zh) | 2003-10-15 |
| CZ96598A3 (cs) | 1998-09-16 |
| KR19990064068A (ko) | 1999-07-26 |
| CZ295518B6 (cs) | 2005-08-17 |
| EP0854928A2 (en) | 1998-07-29 |
| KR100456212B1 (ko) | 2005-01-15 |
| NZ320978A (en) | 2001-03-30 |
| JPH11510062A (ja) | 1999-09-07 |
| NO981500L (no) | 1998-05-20 |
| WO1997012985A2 (en) | 1997-04-10 |
| AU7384496A (en) | 1997-04-28 |
| BRPI9610977A2 (pt) | 2019-09-17 |
| NO981500D0 (no) | 1998-04-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued | ||
| FZDE | Discontinued |
Effective date: 20071004 |