CA2221980A1 - Derives d'isoxazoline et d'isoxadole utilises comme antagonistes des recepteurs de l'integrine - Google Patents
Derives d'isoxazoline et d'isoxadole utilises comme antagonistes des recepteurs de l'integrine Download PDFInfo
- Publication number
- CA2221980A1 CA2221980A1 CA002221980A CA2221980A CA2221980A1 CA 2221980 A1 CA2221980 A1 CA 2221980A1 CA 002221980 A CA002221980 A CA 002221980A CA 2221980 A CA2221980 A CA 2221980A CA 2221980 A1 CA2221980 A1 CA 2221980A1
- Authority
- CA
- Canada
- Prior art keywords
- propionic acid
- isoxazolin
- ylamino
- alkyl
- ylcarbonylamino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Cette invention se rapporte à de nouveaux composés hétérocycliques comprenant notamment, mais pas exclusivement, l'acide 3-[3-[3-(imidazoline-2-yl- amino)propyloxy]isoxasol-5-ylcarbonylamino]-2-(benzyloxycarbonylamino)-propionique et qui sont utilisés comme antagonistes des récepteurs alpha v beta b3 et de l'intégrine apparentée. L'invention se rapporte également aux compositions pharmaceutiques contenant ces composés, aux procédés de préparation et d'utilisation de ces composés, seuls ou associés à d'autres agents thérapeutiques et destinés à être utilisés dans des procédés d'inhibition de l'adhésion cellulaire et de traitement de troubles angiogéniques, des inflammations, de la déperdition osseuse, des tumeurs, des métastases, de la thrombose et d'autres états apparentés à l'agrégation cellulaire.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US45064695A | 1995-05-25 | 1995-05-25 | |
US45576895A | 1995-05-31 | 1995-05-31 | |
US08/647,132 | 1996-05-09 | ||
US08/455,768 | 1996-05-09 | ||
US08/647,132 US5710159A (en) | 1996-05-09 | 1996-05-09 | Integrin receptor antagonists |
US08/450,646 | 1996-05-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2221980A1 true CA2221980A1 (fr) | 1996-11-28 |
Family
ID=27412454
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002221980A Abandoned CA2221980A1 (fr) | 1995-05-25 | 1996-05-24 | Derives d'isoxazoline et d'isoxadole utilises comme antagonistes des recepteurs de l'integrine |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0828737A1 (fr) |
JP (1) | JPH11506436A (fr) |
AU (1) | AU5876296A (fr) |
CA (1) | CA2221980A1 (fr) |
IL (1) | IL118325A0 (fr) |
MX (1) | MX9708840A (fr) |
WO (1) | WO1996037492A1 (fr) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5760028A (en) * | 1995-12-22 | 1998-06-02 | The Dupont Merck Pharmaceutical Company | Integrin receptor antagonists |
JP2001527513A (ja) * | 1996-03-15 | 2001-12-25 | デュポン ファーマシューティカルズ カンパニー | スピロ環インテグリン阻害剤 |
ZA972195B (en) * | 1996-03-15 | 1998-09-14 | Du Pont Merck Pharma | Spirocycle integrin inhibitors |
PT894084E (pt) * | 1996-03-29 | 2002-11-29 | Searle & Co | Derivados de acido cinamico e sua utilizacao como antagonistas de integrina |
WO1997048395A1 (fr) * | 1996-06-19 | 1997-12-24 | Du Pont Pharmaceuticals Company | Administration iontophoretique d'inhibiteurs de l'integrine |
WO1998043962A1 (fr) * | 1997-03-28 | 1998-10-08 | Du Pont Pharmaceuticals Company | Promedicaments heterocycliques inhibiteurs d'integrine |
US6420558B1 (en) | 1998-04-09 | 2002-07-16 | Meiji Seika Kaisha, Ltd. | Aminopiperidine derivates as integrin αvβ3 antagonists |
US6566381B1 (en) * | 1999-03-03 | 2003-05-20 | The Procter & Gamble Company | Hetero-substituted metalloprotease inhibitors |
AU5379900A (en) | 1999-06-07 | 2000-12-28 | Shire Biochem Inc. | Thiophene integrin inhibitors |
CA2378860A1 (fr) | 1999-07-21 | 2001-02-01 | American Home Products Corporation | Antagonistes bicycliques selectifs contre l'integrine .alpha.v.beta.3 |
WO2001010844A1 (fr) | 1999-08-05 | 2001-02-15 | Meiji Seika Kaisha, Ltd. | DERIVES D'ACIDE φ-AMINO-α-HYDROXYCARBOXYLIQUE POSSEDANT UN ANTAGONISME αvβ3 D'INTEGRINE |
KR20020067050A (ko) * | 1999-12-28 | 2002-08-21 | 화이자 프로덕츠 인코포레이티드 | 염증성, 자기면역 및 호흡기 질환의 치료에 유용한브이엘에이-4 의존성 세포 결합의 비펩티드계 억제제 |
DE10029077A1 (de) * | 2000-06-13 | 2001-12-20 | Bayer Ag | Thiazolylsubstituierte Heterocyclen |
KR100594544B1 (ko) * | 2003-08-27 | 2006-06-30 | 주식회사 엘지생명과학 | 이소옥사졸린 구조를 갖는 캐스파제 저해제 |
GB0412553D0 (en) * | 2004-06-04 | 2004-07-07 | Univ Aberdeen | Therapeutic agents for the treatment of bone conditions |
WO2006090234A1 (fr) * | 2005-02-22 | 2006-08-31 | Ranbaxy Laboratories Limited | Derives heterocycliques utilises en tant qu'inhibiteurs d'adherence cellulaire |
GB0705400D0 (en) | 2007-03-21 | 2007-05-02 | Univ Aberdeen | Therapeutic compounds andm their use |
GB0817207D0 (en) | 2008-09-19 | 2008-10-29 | Pimco 2664 Ltd | therapeutic apsac compounds and their use |
GB0817208D0 (en) | 2008-09-19 | 2008-10-29 | Pimco 2664 Ltd | Therapeutic apsap compounds and their use |
US9505728B2 (en) | 2012-03-09 | 2016-11-29 | Inception 2, Inc. | Triazolone compounds and uses thereof |
JP6404230B2 (ja) | 2012-12-20 | 2018-10-10 | インセプション 2、 インコーポレイテッド | トリアゾロン化合物およびその使用 |
GB201311361D0 (en) | 2013-06-26 | 2013-08-14 | Pimco 2664 Ltd | Compounds and their therapeutic use |
CN105579440A (zh) | 2013-09-06 | 2016-05-11 | 因森普深2公司 | 三唑酮化合物及其应用 |
AU2015283850B2 (en) | 2014-07-03 | 2020-06-04 | Board Of Regents, University Of Texas System | GLS1 inhibitors for treating disease |
CA2970578C (fr) | 2014-12-17 | 2024-01-02 | Pimco 2664 Limited | N-(4-hydroxy-4-methylcyclohexyl)-4-phenylbenzenesulfonamides et n-(4-hydroxy-4-methylcyclohexyl)-4-(2-pyridyl)benzenesulfonamides et leur utilisation therapeutique |
JP6895396B2 (ja) | 2015-06-30 | 2021-06-30 | ボード オブ レジェンツ, ザ ユニバーシティ オブ テキサス システムBoard Of Regents, The University Of Texas System | 疾患を処置するためのgls1阻害薬 |
MX2018007143A (es) | 2015-12-22 | 2018-11-29 | Univ Texas | Formas de sales y polimorfos de (r)-1-(4-(6-(2-(4-(3,3-difluorocic lobutoxi)-6-metilpiridin-2-il)acetamido)piridazin-3-il)-2-fluorob util)-n-metil-1h-1,2,3-triazol-4-carboxamida. |
EA201991124A1 (ru) * | 2016-11-08 | 2019-10-31 | ПИРРОЛЬНЫЕ АМИДЫ В КАЧЕСТВЕ ИНГИБИТОРОВ ИНТЕГРИНОВ αV | |
JP7361687B2 (ja) | 2017-10-18 | 2023-10-16 | ボード オブ レジェンツ,ザ ユニバーシティ オブ テキサス システム | グルタミナーゼ阻害薬療法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR900006545B1 (ko) * | 1986-03-14 | 1990-09-13 | 신텍스(미합중국) 인코포레이티드 | 트란스글루타미나제 억제제 |
DE4124942A1 (de) * | 1991-07-27 | 1993-01-28 | Thomae Gmbh Dr K | 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
AU674553B2 (en) * | 1992-10-14 | 1997-01-02 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
HUT74690A (en) * | 1993-11-24 | 1997-01-28 | Du Pont Merck Pharma | Novel isoxazoline and isoxazole fibrinogen receptor antagonists process for producing them and pharmaceutical compositions containing them |
-
1996
- 1996-05-20 IL IL11832596A patent/IL118325A0/xx unknown
- 1996-05-24 EP EP96920476A patent/EP0828737A1/fr not_active Ceased
- 1996-05-24 AU AU58762/96A patent/AU5876296A/en not_active Abandoned
- 1996-05-24 JP JP8535899A patent/JPH11506436A/ja active Pending
- 1996-05-24 MX MX9708840A patent/MX9708840A/es unknown
- 1996-05-24 CA CA002221980A patent/CA2221980A1/fr not_active Abandoned
- 1996-05-24 WO PCT/US1996/007646 patent/WO1996037492A1/fr not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
IL118325A0 (en) | 1996-10-31 |
WO1996037492A1 (fr) | 1996-11-28 |
JPH11506436A (ja) | 1999-06-08 |
EP0828737A1 (fr) | 1998-03-18 |
MX9708840A (es) | 1998-03-31 |
AU5876296A (en) | 1996-12-11 |
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CA2221980A1 (fr) | Derives d'isoxazoline et d'isoxadole utilises comme antagonistes des recepteurs de l'integrine | |
AU723577B2 (en) | Novel isoxazoline and isoxazole fibrinogen receptor antagonists | |
DE69426604T2 (de) | Isoxazoline und isoxazole derivate als fibrinogen rezeptor antagonisten | |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued |