CA2221980A1 - Derives d'isoxazoline et d'isoxadole utilises comme antagonistes des recepteurs de l'integrine - Google Patents

Derives d'isoxazoline et d'isoxadole utilises comme antagonistes des recepteurs de l'integrine Download PDF

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Publication number
CA2221980A1
CA2221980A1 CA002221980A CA2221980A CA2221980A1 CA 2221980 A1 CA2221980 A1 CA 2221980A1 CA 002221980 A CA002221980 A CA 002221980A CA 2221980 A CA2221980 A CA 2221980A CA 2221980 A1 CA2221980 A1 CA 2221980A1
Authority
CA
Canada
Prior art keywords
propionic acid
isoxazolin
ylamino
alkyl
ylcarbonylamino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002221980A
Other languages
English (en)
Inventor
Matthew Ernst Voss
Prabhakar Kondaji Jadhav
Joanne Marie Smallheer
Douglas Guy Batt
William John Pitts
John Wityak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Pharma Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/647,132 external-priority patent/US5710159A/en
Application filed by Individual filed Critical Individual
Publication of CA2221980A1 publication Critical patent/CA2221980A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Cette invention se rapporte à de nouveaux composés hétérocycliques comprenant notamment, mais pas exclusivement, l'acide 3-[3-[3-(imidazoline-2-yl- amino)propyloxy]isoxasol-5-ylcarbonylamino]-2-(benzyloxycarbonylamino)-propionique et qui sont utilisés comme antagonistes des récepteurs alpha v beta b3 et de l'intégrine apparentée. L'invention se rapporte également aux compositions pharmaceutiques contenant ces composés, aux procédés de préparation et d'utilisation de ces composés, seuls ou associés à d'autres agents thérapeutiques et destinés à être utilisés dans des procédés d'inhibition de l'adhésion cellulaire et de traitement de troubles angiogéniques, des inflammations, de la déperdition osseuse, des tumeurs, des métastases, de la thrombose et d'autres états apparentés à l'agrégation cellulaire.
CA002221980A 1995-05-25 1996-05-24 Derives d'isoxazoline et d'isoxadole utilises comme antagonistes des recepteurs de l'integrine Abandoned CA2221980A1 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US45064695A 1995-05-25 1995-05-25
US45576895A 1995-05-31 1995-05-31
US08/647,132 1996-05-09
US08/455,768 1996-05-09
US08/647,132 US5710159A (en) 1996-05-09 1996-05-09 Integrin receptor antagonists
US08/450,646 1996-05-09

Publications (1)

Publication Number Publication Date
CA2221980A1 true CA2221980A1 (fr) 1996-11-28

Family

ID=27412454

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002221980A Abandoned CA2221980A1 (fr) 1995-05-25 1996-05-24 Derives d'isoxazoline et d'isoxadole utilises comme antagonistes des recepteurs de l'integrine

Country Status (7)

Country Link
EP (1) EP0828737A1 (fr)
JP (1) JPH11506436A (fr)
AU (1) AU5876296A (fr)
CA (1) CA2221980A1 (fr)
IL (1) IL118325A0 (fr)
MX (1) MX9708840A (fr)
WO (1) WO1996037492A1 (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5760028A (en) * 1995-12-22 1998-06-02 The Dupont Merck Pharmaceutical Company Integrin receptor antagonists
JP2001527513A (ja) * 1996-03-15 2001-12-25 デュポン ファーマシューティカルズ カンパニー スピロ環インテグリン阻害剤
ZA972195B (en) * 1996-03-15 1998-09-14 Du Pont Merck Pharma Spirocycle integrin inhibitors
PT894084E (pt) * 1996-03-29 2002-11-29 Searle & Co Derivados de acido cinamico e sua utilizacao como antagonistas de integrina
WO1997048395A1 (fr) * 1996-06-19 1997-12-24 Du Pont Pharmaceuticals Company Administration iontophoretique d'inhibiteurs de l'integrine
WO1998043962A1 (fr) * 1997-03-28 1998-10-08 Du Pont Pharmaceuticals Company Promedicaments heterocycliques inhibiteurs d'integrine
US6420558B1 (en) 1998-04-09 2002-07-16 Meiji Seika Kaisha, Ltd. Aminopiperidine derivates as integrin αvβ3 antagonists
US6566381B1 (en) * 1999-03-03 2003-05-20 The Procter & Gamble Company Hetero-substituted metalloprotease inhibitors
AU5379900A (en) 1999-06-07 2000-12-28 Shire Biochem Inc. Thiophene integrin inhibitors
CA2378860A1 (fr) 1999-07-21 2001-02-01 American Home Products Corporation Antagonistes bicycliques selectifs contre l'integrine .alpha.v.beta.3
WO2001010844A1 (fr) 1999-08-05 2001-02-15 Meiji Seika Kaisha, Ltd. DERIVES D'ACIDE φ-AMINO-α-HYDROXYCARBOXYLIQUE POSSEDANT UN ANTAGONISME αvβ3 D'INTEGRINE
KR20020067050A (ko) * 1999-12-28 2002-08-21 화이자 프로덕츠 인코포레이티드 염증성, 자기면역 및 호흡기 질환의 치료에 유용한브이엘에이-4 의존성 세포 결합의 비펩티드계 억제제
DE10029077A1 (de) * 2000-06-13 2001-12-20 Bayer Ag Thiazolylsubstituierte Heterocyclen
KR100594544B1 (ko) * 2003-08-27 2006-06-30 주식회사 엘지생명과학 이소옥사졸린 구조를 갖는 캐스파제 저해제
GB0412553D0 (en) * 2004-06-04 2004-07-07 Univ Aberdeen Therapeutic agents for the treatment of bone conditions
WO2006090234A1 (fr) * 2005-02-22 2006-08-31 Ranbaxy Laboratories Limited Derives heterocycliques utilises en tant qu'inhibiteurs d'adherence cellulaire
GB0705400D0 (en) 2007-03-21 2007-05-02 Univ Aberdeen Therapeutic compounds andm their use
GB0817207D0 (en) 2008-09-19 2008-10-29 Pimco 2664 Ltd therapeutic apsac compounds and their use
GB0817208D0 (en) 2008-09-19 2008-10-29 Pimco 2664 Ltd Therapeutic apsap compounds and their use
US9505728B2 (en) 2012-03-09 2016-11-29 Inception 2, Inc. Triazolone compounds and uses thereof
JP6404230B2 (ja) 2012-12-20 2018-10-10 インセプション ２、 インコーポレイテッド トリアゾロン化合物およびその使用
GB201311361D0 (en) 2013-06-26 2013-08-14 Pimco 2664 Ltd Compounds and their therapeutic use
CN105579440A (zh) 2013-09-06 2016-05-11 因森普深2公司 三唑酮化合物及其应用
AU2015283850B2 (en) 2014-07-03 2020-06-04 Board Of Regents, University Of Texas System GLS1 inhibitors for treating disease
CA2970578C (fr) 2014-12-17 2024-01-02 Pimco 2664 Limited N-(4-hydroxy-4-methylcyclohexyl)-4-phenylbenzenesulfonamides et n-(4-hydroxy-4-methylcyclohexyl)-4-(2-pyridyl)benzenesulfonamides et leur utilisation therapeutique
JP6895396B2 (ja) 2015-06-30 2021-06-30 ボード オブ レジェンツ, ザ ユニバーシティ オブ テキサス システムBoard Of Regents, The University Of Texas System 疾患を処置するためのｇｌｓ１阻害薬
MX2018007143A (es) 2015-12-22 2018-11-29 Univ Texas Formas de sales y polimorfos de (r)-1-(4-(6-(2-(4-(3,3-difluorocic lobutoxi)-6-metilpiridin-2-il)acetamido)piridazin-3-il)-2-fluorob util)-n-metil-1h-1,2,3-triazol-4-carboxamida.
EA201991124A1 (ru) * 2016-11-08 2019-10-31 ПИРРОЛЬНЫЕ АМИДЫ В КАЧЕСТВЕ ИНГИБИТОРОВ ИНТЕГРИНОВ αV
JP7361687B2 (ja) 2017-10-18 2023-10-16 ボード オブ レジェンツ，ザ ユニバーシティ オブ テキサス システム グルタミナーゼ阻害薬療法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR900006545B1 (ko) * 1986-03-14 1990-09-13 신텍스(미합중국) 인코포레이티드 트란스글루타미나제 억제제
DE4124942A1 (de) * 1991-07-27 1993-01-28 Thomae Gmbh Dr K 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
AU674553B2 (en) * 1992-10-14 1997-01-02 Merck & Co., Inc. Fibrinogen receptor antagonists
HUT74690A (en) * 1993-11-24 1997-01-28 Du Pont Merck Pharma Novel isoxazoline and isoxazole fibrinogen receptor antagonists process for producing them and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
IL118325A0 (en) 1996-10-31
WO1996037492A1 (fr) 1996-11-28
JPH11506436A (ja) 1999-06-08
EP0828737A1 (fr) 1998-03-18
MX9708840A (es) 1998-03-31
AU5876296A (en) 1996-12-11

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Legal Events

Date Code Title Description
FZDE Discontinued