IL118325A0 - Integrin receptor antagonists and pharmaceutical compositions containing them - Google Patents

Integrin receptor antagonists and pharmaceutical compositions containing them

Info

Publication number
IL118325A0
IL118325A0 IL11832596A IL11832596A IL118325A0 IL 118325 A0 IL118325 A0 IL 118325A0 IL 11832596 A IL11832596 A IL 11832596A IL 11832596 A IL11832596 A IL 11832596A IL 118325 A0 IL118325 A0 IL 118325A0
Authority
IL
Israel
Prior art keywords
pharmaceutical compositions
compositions containing
receptor antagonists
integrin receptor
integrin
Prior art date
Application number
IL11832596A
Other languages
English (en)
Original Assignee
Pont Merck And Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/647,132 external-priority patent/US5710159A/en
Application filed by Pont Merck And Pharmaceutical filed Critical Pont Merck And Pharmaceutical
Publication of IL118325A0 publication Critical patent/IL118325A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
IL11832596A 1995-05-25 1996-05-20 Integrin receptor antagonists and pharmaceutical compositions containing them IL118325A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US45064695A 1995-05-25 1995-05-25
US45576895A 1995-05-31 1995-05-31
US08/647,132 US5710159A (en) 1996-05-09 1996-05-09 Integrin receptor antagonists

Publications (1)

Publication Number Publication Date
IL118325A0 true IL118325A0 (en) 1996-10-31

Family

ID=27412454

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11832596A IL118325A0 (en) 1995-05-25 1996-05-20 Integrin receptor antagonists and pharmaceutical compositions containing them

Country Status (7)

Country Link
EP (1) EP0828737A1 (fr)
JP (1) JPH11506436A (fr)
AU (1) AU5876296A (fr)
CA (1) CA2221980A1 (fr)
IL (1) IL118325A0 (fr)
MX (1) MX9708840A (fr)
WO (1) WO1996037492A1 (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5760028A (en) * 1995-12-22 1998-06-02 The Dupont Merck Pharmaceutical Company Integrin receptor antagonists
EP0888344A1 (fr) * 1996-03-15 1999-01-07 The Du Pont Merck Pharmaceutical Company Inhibiteurs de l'integrine spirocycle
ZA972195B (en) * 1996-03-15 1998-09-14 Du Pont Merck Pharma Spirocycle integrin inhibitors
DK0894084T3 (da) * 1996-03-29 2002-10-14 Searle & Co Kanelsyrederivater og deres anvendelse som integrinantagonister
US6185453B1 (en) 1996-06-19 2001-02-06 Dupont Pharmaceuticals Company Iontophoretic delivery of integrin inhibitors
US6214834B1 (en) 1997-03-28 2001-04-10 Dupont Pharmaceuticals Company Integrin inhibitor prodrugs
NZ507222A (en) 1998-04-09 2003-05-30 Meiji Seika Kaisha Aminopiperidine derivatives useful as integrin antagonists
CZ20013155A3 (cs) * 1999-03-03 2002-01-16 The Procter & Gamble Company Inhibitory metaloproteas
AU5379900A (en) * 1999-06-07 2000-12-28 Shire Biochem Inc. Thiophene integrin inhibitors
EP1198231A1 (fr) 1999-07-21 2002-04-24 American Home Products Corporation Antagonistes bicycliques selectifs contre l'integrine(alpha)v (beta)3
WO2001010844A1 (fr) 1999-08-05 2001-02-15 Meiji Seika Kaisha, Ltd. DERIVES D'ACIDE φ-AMINO-α-HYDROXYCARBOXYLIQUE POSSEDANT UN ANTAGONISME αvβ3 D'INTEGRINE
SK8692002A3 (en) * 1999-12-28 2003-06-03 Pfizer Prod Inc Non-peptidyl inhibitors of VLA-4 dependent cell binding useful in treating inflammatory, autoimmune, and respiratory diseases
DE10029077A1 (de) * 2000-06-13 2001-12-20 Bayer Ag Thiazolylsubstituierte Heterocyclen
KR100594544B1 (ko) * 2003-08-27 2006-06-30 주식회사 엘지생명과학 이소옥사졸린 구조를 갖는 캐스파제 저해제
GB0412553D0 (en) 2004-06-04 2004-07-07 Univ Aberdeen Therapeutic agents for the treatment of bone conditions
WO2006090234A1 (fr) * 2005-02-22 2006-08-31 Ranbaxy Laboratories Limited Derives heterocycliques utilises en tant qu'inhibiteurs d'adherence cellulaire
GB0705400D0 (en) 2007-03-21 2007-05-02 Univ Aberdeen Therapeutic compounds andm their use
GB0817208D0 (en) 2008-09-19 2008-10-29 Pimco 2664 Ltd Therapeutic apsap compounds and their use
GB0817207D0 (en) 2008-09-19 2008-10-29 Pimco 2664 Ltd therapeutic apsac compounds and their use
US9505728B2 (en) 2012-03-09 2016-11-29 Inception 2, Inc. Triazolone compounds and uses thereof
MX2015007433A (es) 2012-12-20 2015-12-07 Inception 2 Inc Compuestos de triazolona y usos de los mismos.
GB201311361D0 (en) 2013-06-26 2013-08-14 Pimco 2664 Ltd Compounds and their therapeutic use
WO2015035059A1 (fr) 2013-09-06 2015-03-12 Inception 2, Inc. Composés de triazolone et leurs utilisations
US9809588B2 (en) 2014-07-03 2017-11-07 Board Of Regents, The University Of Texas System GLS1 inhibitors for treating disease
LT3262028T (lt) 2014-12-17 2022-01-10 Pimco 2664 Limited N-(4-hidroksi-4-metil-cikloheksil)-4-fenil-benzensulfonamido ir n-(-4-hidroksi-4-metil-cikloheksil)-4-(2-piridil)-benzensulfonamido junginiai ir jų terapinis panaudojimas
WO2017004359A1 (fr) 2015-06-30 2017-01-05 Board Of Regents, University Of Texas System Inhibiteurs de gls1 pour le traitement de maladies
CA3009355A1 (fr) 2015-12-22 2017-06-29 Board Of Regents, The University Of Texas System Formes de sels et polymorphes de (r)-1-(4-(6-(2-(4-(3,3-difluorocyclobutoxy)-6-methylpyridine-2-yl) acetamido)pyridazine-3-yl)-2-fluorobutyl)-n-methyl-1h-1,2,3-triazole-4-carboxamide
CA3042693A1 (fr) * 2016-11-08 2018-05-17 Bristol-Myers Squibb Company Amides de pyrrole en tant qu'inhibiteurs d'integrine .alpha.v
RU2020112558A (ru) 2017-10-18 2021-11-18 Боард Оф Регентс, Зе Юниверсити Оф Тексас Систем Терапия на основе ингибитора глутаминазы

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62252779A (ja) * 1986-03-14 1987-11-04 シンテツクス（ユ−・エス・エイ）インコ−ポレイテツド トランスグルタミナ−ゼ阻害剤
DE4124942A1 (de) * 1991-07-27 1993-01-28 Thomae Gmbh Dr K 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
WO1994008577A1 (fr) * 1992-10-14 1994-04-28 Merck & Co., Inc. Antagonistes des recepteurs du fibrinogene
JPH09505590A (ja) * 1993-11-24 1997-06-03 ザ・デュポン・メルク・ファーマシュウティカル・カンパニー 新規なイソオキサゾリンおよびイソオキサゾールフィブリノーゲン受容体拮抗剤

Also Published As

Publication number Publication date
MX9708840A (es) 1998-03-31
WO1996037492A1 (fr) 1996-11-28
JPH11506436A (ja) 1999-06-08
EP0828737A1 (fr) 1998-03-18
AU5876296A (en) 1996-12-11
CA2221980A1 (fr) 1996-11-28

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