MX9708840A - Derivados de isoxazolina e isoxazol como antagonistas del receptor integrina. - Google Patents
Derivados de isoxazolina e isoxazol como antagonistas del receptor integrina.Info
- Publication number
- MX9708840A MX9708840A MX9708840A MX9708840A MX9708840A MX 9708840 A MX9708840 A MX 9708840A MX 9708840 A MX9708840 A MX 9708840A MX 9708840 A MX9708840 A MX 9708840A MX 9708840 A MX9708840 A MX 9708840A
- Authority
- MX
- Mexico
- Prior art keywords
- compounds
- isoxazoline
- receptor antagonists
- integrin receptor
- isoxazole derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Esta invencion se relaciona con compuestos heterocíclicos novedosos incluyendo, pero sin limitar al ácido 3-[3-[3-(imidazolin-2-ilamino)propiloxi]isoxazol-5 -ilcarbonilamino]-2-(benciloxicarbonilamino)-propi onico, los cuales son utiles como antagonistas del alfav beta3 y receptores integrina relacionados, con las composiciones farmacéuticas que contienen tales compuestos, los procesos para preparar tales compuestos, y con los métodos de uso de esos compuestos, solos o en combinacion con otros agentes terapéuticos, para la inhibicion de la adhesion celular y el tratamiento de procedimientos angiogénicos, inflamacion, degradacion osea, tumores, metástasis, trombosis, y otras condiciones relacionadas con la agregacion celular.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US45064695A | 1995-05-25 | 1995-05-25 | |
US45576895A | 1995-05-31 | 1995-05-31 | |
US08/647,132 US5710159A (en) | 1996-05-09 | 1996-05-09 | Integrin receptor antagonists |
PCT/US1996/007646 WO1996037492A1 (en) | 1995-05-25 | 1996-05-24 | Isoxazoline and isoxazole derivatives as integrin receptor antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9708840A true MX9708840A (es) | 1998-03-31 |
Family
ID=27412454
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9708840A MX9708840A (es) | 1995-05-25 | 1996-05-24 | Derivados de isoxazolina e isoxazol como antagonistas del receptor integrina. |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0828737A1 (es) |
JP (1) | JPH11506436A (es) |
AU (1) | AU5876296A (es) |
CA (1) | CA2221980A1 (es) |
IL (1) | IL118325A0 (es) |
MX (1) | MX9708840A (es) |
WO (1) | WO1996037492A1 (es) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5760028A (en) * | 1995-12-22 | 1998-06-02 | The Dupont Merck Pharmaceutical Company | Integrin receptor antagonists |
ZA972195B (en) * | 1996-03-15 | 1998-09-14 | Du Pont Merck Pharma | Spirocycle integrin inhibitors |
CA2249733A1 (en) * | 1996-03-15 | 1997-09-18 | Du Pont Pharmaceuticals Company | Spirocycle integrin inhibitors |
EP0894084B1 (en) * | 1996-03-29 | 2002-06-26 | G.D. Searle & Co. | Cinnamic acid derivatives and their use as integrin antagonists |
AU3640997A (en) | 1996-06-19 | 1998-01-07 | Du Pont Pharmaceuticals Company | Iontophoretic delivery of integrin inhibitors |
WO1998043962A1 (en) * | 1997-03-28 | 1998-10-08 | Du Pont Pharmaceuticals Company | Heterocyclic integrin inhibitor prodrugs |
AU759449C (en) | 1998-04-09 | 2003-10-30 | Meiji Seika Pharma Co.,Ltd. | Aminopiperidine derivatives as integrin alpha v beta 3 antagonists |
EP1165530A2 (en) * | 1999-03-03 | 2002-01-02 | The Procter & Gamble Company | Dihetero-substituted metalloprotease inhibitors |
AU5379900A (en) | 1999-06-07 | 2000-12-28 | Shire Biochem Inc. | Thiophene integrin inhibitors |
US6429214B1 (en) | 1999-07-21 | 2002-08-06 | Wyeth | Bicyclic antagonists selective for the αvβ3 integrin |
AU6316900A (en) | 1999-08-05 | 2001-03-05 | Meiji Seika Kaisha Ltd. | Omega-amino-alpha-hydroxycarboxylic acid derivatives having integrin alphavbeta3antagonism |
CN1413210A (zh) * | 1999-12-28 | 2003-04-23 | 辉瑞产品公司 | 用于治疗炎症、自身免疫性疾病和呼吸系统疾病的vla-4依赖性细胞结合的非肽基抑制剂 |
DE10029077A1 (de) * | 2000-06-13 | 2001-12-20 | Bayer Ag | Thiazolylsubstituierte Heterocyclen |
KR100594544B1 (ko) * | 2003-08-27 | 2006-06-30 | 주식회사 엘지생명과학 | 이소옥사졸린 구조를 갖는 캐스파제 저해제 |
GB0412553D0 (en) | 2004-06-04 | 2004-07-07 | Univ Aberdeen | Therapeutic agents for the treatment of bone conditions |
WO2006090234A1 (en) * | 2005-02-22 | 2006-08-31 | Ranbaxy Laboratories Limited | Heterocyclic derivatives as cell adhesion inhibitors |
GB0705400D0 (en) | 2007-03-21 | 2007-05-02 | Univ Aberdeen | Therapeutic compounds andm their use |
GB0817208D0 (en) | 2008-09-19 | 2008-10-29 | Pimco 2664 Ltd | Therapeutic apsap compounds and their use |
GB0817207D0 (en) | 2008-09-19 | 2008-10-29 | Pimco 2664 Ltd | therapeutic apsac compounds and their use |
WO2013134562A1 (en) | 2012-03-09 | 2013-09-12 | Inception 2, Inc. | Triazolone compounds and uses thereof |
CA2894281C (en) | 2012-12-20 | 2021-04-20 | Inception 2, Inc. | Triazolone compounds and uses thereof |
GB201311361D0 (en) | 2013-06-26 | 2013-08-14 | Pimco 2664 Ltd | Compounds and their therapeutic use |
PE20160880A1 (es) | 2013-09-06 | 2016-09-22 | Inception 2 Inc | Compuestos de triazolona y usos de los mismos |
LT3164394T (lt) | 2014-07-03 | 2020-05-25 | Board Of Regents, The University Of Texas System | Gls1 inhibitoriai, skirti ligų gydymui |
EP3262028B1 (en) | 2014-12-17 | 2021-10-27 | Pimco 2664 Limited | N-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamide and n-(-4hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)-benzenesulfonamide compounds and their therapeutic use |
JP6895396B2 (ja) | 2015-06-30 | 2021-06-30 | ボード オブ レジェンツ, ザ ユニバーシティ オブ テキサス システムBoard Of Regents, The University Of Texas System | 疾患を処置するためのgls1阻害薬 |
SG11201804664XA (en) | 2015-12-22 | 2018-07-30 | Univ Texas | Salt forms and polymorphs of (r)-1-(4-(6-(2-(4-(3,3-difluorocyclobutoxy)-6-methylpyridin-2-yl) acetamido) pyridazin-3-yl)-2-fluorobutyl)-n-methyl-1h-1,2,3-triazole-4-carboxamide |
PT3538528T (pt) * | 2016-11-08 | 2021-02-16 | Bristol Myers Squibb Co | Pirrol amidas como inibidores de integrina v |
RU2020112558A (ru) | 2017-10-18 | 2021-11-18 | Боард Оф Регентс, Зе Юниверсити Оф Тексас Систем | Терапия на основе ингибитора глутаминазы |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3770294D1 (de) * | 1986-03-14 | 1991-07-04 | Syntex Inc | 3,5-disubstituierte 4,5-dihydroisoxazole als transglutaminasehemmer. |
DE4124942A1 (de) * | 1991-07-27 | 1993-01-28 | Thomae Gmbh Dr K | 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
AU674553B2 (en) * | 1992-10-14 | 1997-01-02 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
BR9408137A (pt) * | 1993-11-24 | 1997-08-12 | Du Pont Merck Pharma | Composto éster de prodroga método de tratamento composição farmacêutica e método de inibição |
-
1996
- 1996-05-20 IL IL11832596A patent/IL118325A0/xx unknown
- 1996-05-24 WO PCT/US1996/007646 patent/WO1996037492A1/en not_active Application Discontinuation
- 1996-05-24 MX MX9708840A patent/MX9708840A/es unknown
- 1996-05-24 JP JP8535899A patent/JPH11506436A/ja active Pending
- 1996-05-24 EP EP96920476A patent/EP0828737A1/en not_active Ceased
- 1996-05-24 AU AU58762/96A patent/AU5876296A/en not_active Abandoned
- 1996-05-24 CA CA002221980A patent/CA2221980A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP0828737A1 (en) | 1998-03-18 |
CA2221980A1 (en) | 1996-11-28 |
JPH11506436A (ja) | 1999-06-08 |
WO1996037492A1 (en) | 1996-11-28 |
IL118325A0 (en) | 1996-10-31 |
AU5876296A (en) | 1996-12-11 |
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