CA2210823C - Pharmaceutical compositions comprising lactobacilli suitable for trans-mucosal administration - Google Patents
Pharmaceutical compositions comprising lactobacilli suitable for trans-mucosal administration Download PDFInfo
- Publication number
- CA2210823C CA2210823C CA002210823A CA2210823A CA2210823C CA 2210823 C CA2210823 C CA 2210823C CA 002210823 A CA002210823 A CA 002210823A CA 2210823 A CA2210823 A CA 2210823A CA 2210823 C CA2210823 C CA 2210823C
- Authority
- CA
- Canada
- Prior art keywords
- weight
- capsules
- lactobacilli
- trans
- pharmaceutical compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 241000186660 Lactobacillus Species 0.000 title description 6
- 239000008194 pharmaceutical composition Substances 0.000 title description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 23
- 239000002775 capsule Substances 0.000 claims abstract description 15
- 241000186840 Lactobacillus fermentum Species 0.000 claims abstract description 8
- 229940012969 lactobacillus fermentum Drugs 0.000 claims abstract description 8
- 239000000741 silica gel Substances 0.000 claims abstract description 7
- 229910002027 silica gel Inorganic materials 0.000 claims abstract description 7
- 239000000377 silicon dioxide Substances 0.000 claims abstract description 7
- 108010010803 Gelatin Proteins 0.000 claims abstract description 6
- 239000008273 gelatin Substances 0.000 claims abstract description 6
- 229920000159 gelatin Polymers 0.000 claims abstract description 6
- 235000019322 gelatine Nutrition 0.000 claims abstract description 6
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 6
- 239000000203 mixture Substances 0.000 claims description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 7
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 4
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 2
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 2
- 239000007903 gelatin capsule Substances 0.000 claims description 2
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 2
- 239000004408 titanium dioxide Substances 0.000 claims description 2
- 235000011187 glycerol Nutrition 0.000 claims 1
- 229940057917 medium chain triglycerides Drugs 0.000 claims 1
- 235000010215 titanium dioxide Nutrition 0.000 claims 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
- 230000001580 bacterial effect Effects 0.000 description 5
- 239000000546 pharmaceutical excipient Substances 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 229910002018 Aerosil® 300 Inorganic materials 0.000 description 2
- 230000003833 cell viability Effects 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 229940039696 lactobacillus Drugs 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 241000222122 Candida albicans Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000000181 anti-adherent effect Effects 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 239000007963 capsule composition Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 238000013467 fragmentation Methods 0.000 description 1
- 238000006062 fragmentation reaction Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000008359 glycogelatin Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000008203 oral pharmaceutical composition Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/485—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Inorganic Chemistry (AREA)
- Gynecology & Obstetrics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97830169A EP0872231B1 (en) | 1997-04-14 | 1997-04-14 | Pharmaceutical compositions comprising lactobacilli suitable for trans-mucosal administration |
| EP97830169.5 | 1997-04-14 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2210823A1 CA2210823A1 (en) | 1998-10-14 |
| CA2210823C true CA2210823C (en) | 2001-04-03 |
Family
ID=8230610
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002210823A Expired - Fee Related CA2210823C (en) | 1997-04-14 | 1997-07-17 | Pharmaceutical compositions comprising lactobacilli suitable for trans-mucosal administration |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0872231B1 (ja) |
| JP (1) | JPH10287573A (ja) |
| AT (1) | ATE223199T1 (ja) |
| CA (1) | CA2210823C (ja) |
| DE (1) | DE69715148D1 (ja) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1304313A (zh) * | 1998-06-05 | 2001-07-18 | 若素制药株式会社 | 含乳酸菌的组合物、药物和食物 |
| JP4603116B2 (ja) * | 1999-12-02 | 2010-12-22 | わかもと製薬株式会社 | 乳酸菌含有組成物、医薬及び食品 |
| US7214370B2 (en) | 2000-12-18 | 2007-05-08 | Probiohealth, Llc | Prebiotic and preservative uses of oil-emulsified probiotic encapsulations |
| KR100484480B1 (ko) * | 2001-05-04 | 2005-04-20 | 정 호 김 | 표면 막처리된 락토바실러스 퍼멘텀 yl-3 캡슐 |
| US20040033968A1 (en) * | 2002-08-16 | 2004-02-19 | Lin Shun Y. | Optimal volume of intra-vaginal semisolid dosage forms for treating vaginal infections |
| CA2820023A1 (en) * | 2002-09-26 | 2007-12-19 | Vita-Herb Nutriceuticals, Inc. | Prebiotic and preservative uses of oil-emulsified probiotic encapsulations |
| JP2010531149A (ja) * | 2007-06-28 | 2010-09-24 | セーホーエル．ハンセン アクティーゼルスカブ | 細胞懸濁液の処理 |
| US20090238796A1 (en) * | 2008-03-24 | 2009-09-24 | Tamara Vasilevna Maculevich | Preparation for treatment of non-infectious inflammatory intestinal diseases |
| EP2158916A1 (en) * | 2008-08-27 | 2010-03-03 | Ellen Aktiebolag | Administration unit comprising lactic acid bacteria |
| US8785183B2 (en) * | 2010-09-21 | 2014-07-22 | Biogaia Ab | Active plastic material in oil |
| WO2014106541A1 (en) * | 2013-01-04 | 2014-07-10 | Ellen Ab | Dermal composition for use in the external genital area in females |
| KR20230059753A (ko) * | 2021-10-26 | 2023-05-03 | 일동제약(주) | 락토바실러스 크리스파투스 균주 및 이를 포함하는 질염의 예방 또는 치료용 조성물 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK242083D0 (da) * | 1983-05-27 | 1983-05-27 | Hansens Chr Bio Syst | Vaginalkapsler |
| US4956295A (en) * | 1984-05-21 | 1990-09-11 | Chr. Hansen's Laboratory, Inc. | Stabilization of dried bacteria extended in particulate carriers |
| IT1227154B (it) * | 1988-08-05 | 1991-03-19 | A Tosi Farmaceutici S R L Nova | Composizioni farmaceutiche per uso ginecologico a base di lattobacilli |
-
1997
- 1997-04-14 EP EP97830169A patent/EP0872231B1/en not_active Expired - Lifetime
- 1997-04-14 DE DE69715148T patent/DE69715148D1/de not_active Expired - Lifetime
- 1997-04-14 AT AT97830169T patent/ATE223199T1/de not_active IP Right Cessation
- 1997-07-17 CA CA002210823A patent/CA2210823C/en not_active Expired - Fee Related
- 1997-08-08 JP JP9227620A patent/JPH10287573A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JPH10287573A (ja) | 1998-10-27 |
| CA2210823A1 (en) | 1998-10-14 |
| DE69715148D1 (de) | 2002-10-10 |
| EP0872231A1 (en) | 1998-10-21 |
| EP0872231B1 (en) | 2002-09-04 |
| ATE223199T1 (de) | 2002-09-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2210823C (en) | Pharmaceutical compositions comprising lactobacilli suitable for trans-mucosal administration | |
| EP0067539B1 (en) | Sustained release pharmaceutical composition | |
| EP0828499B1 (en) | Micro-encapsulated lactobacilli for medical applications | |
| US5294448A (en) | Delayed release formulations | |
| EP1074263B1 (en) | Pharmaceutical compositions of cyclosporine with a polyethoylate saturated hydroxy-fatty acid | |
| CA2050067C (en) | Controlled drug release composition | |
| IE970588A1 (en) | Controlled release pharmaceutical compositions containing tiagabine | |
| GB2139892A (en) | Solid pharmaceutical preparation containing nifedipine | |
| AU2016204815B2 (en) | Bacterial compositions | |
| WO2001041770A3 (en) | Nanoparticulate eplerenone compositions | |
| IL146889A (en) | Combination of lactic acid bacteria and its use for the prevention and / or treatment of infections and inflammatory conditions | |
| CA2257841A1 (en) | Medicinal aerosol formulations of formoterol | |
| JPH0759498B2 (ja) | 長期持続接着性抗真菌坐薬 | |
| CA2419993A1 (en) | Process for preparing pharmaceutical compositions for use with soft gelatin formulations | |
| TW200503775A (en) | Pharmaceutical composition and method for treating | |
| JP2936209B2 (ja) | サイクロスポリン含有組成物およびその製造方法 | |
| JP2000516267A (ja) | 経口シクロスポリン調合剤 | |
| RU2001133455A (ru) | Включающие циклоспорин композиции, практически не содержащие масла | |
| EP1007006A1 (en) | Cefadroxil monohydrate tablet formulation | |
| JP3009742B2 (ja) | 経口用シクロスポリン製剤 | |
| JPH10139670A (ja) | インターロイキン１２誘導物質及び医薬組成物 | |
| MXPA01012751A (es) | Microgranulos de sulfato de morfina, procedimiento para su preparacion y composicion que los contiene. | |
| TWI535463B (zh) | 醫藥固形製劑用之包衣劑、醫藥用膜衣製劑及被覆醫藥固形製劑 | |
| GB2098867A (en) | Sustained release pharmaceutical composition | |
| ES8800040A1 (es) | Procedimiento para la obtencion de una composicion farmaceutica de liberacion retardada a base de 9,10-dihidro-alcaloides. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20130717 |