CA2203621C - Use of hyaluronic acid for the treatment of interstitial cystitis - Google Patents
Use of hyaluronic acid for the treatment of interstitial cystitisInfo
- Publication number
- CA2203621C CA2203621C CA002203621A CA2203621A CA2203621C CA 2203621 C CA2203621 C CA 2203621C CA 002203621 A CA002203621 A CA 002203621A CA 2203621 A CA2203621 A CA 2203621A CA 2203621 C CA2203621 C CA 2203621C
- Authority
- CA
- Canada
- Prior art keywords
- bladder
- interstitial cystitis
- treatment
- daltons
- molecular weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title claims abstract description 121
- 229920002674 hyaluronan Polymers 0.000 title claims abstract description 121
- 229960003160 hyaluronic acid Drugs 0.000 title claims abstract description 121
- 208000005615 Interstitial Cystitis Diseases 0.000 title claims abstract description 70
- 238000011282 treatment Methods 0.000 title description 55
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicinal Preparation (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/388,038 US5591724A (en) | 1995-02-14 | 1995-02-14 | Method for treating the urinary bladder and associated structures using hyaluronic acid |
| US08/388,038 | 1995-02-14 | ||
| US59101596A | 1996-02-08 | 1996-02-08 | |
| US08/591,015 | 1996-02-08 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2203621A1 CA2203621A1 (en) | 1996-08-22 |
| CA2203621C true CA2203621C (en) | 1998-04-28 |
Family
ID=27012116
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002203621A Expired - Lifetime CA2203621C (en) | 1995-02-14 | 1996-02-14 | Use of hyaluronic acid for the treatment of interstitial cystitis |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5888986A (d) |
| EP (1) | EP0813417B1 (d) |
| JP (1) | JP4354528B2 (d) |
| KR (1) | KR100268660B1 (d) |
| CN (1) | CN1181016A (d) |
| AT (1) | ATE247476T1 (d) |
| AU (1) | AU705289B2 (d) |
| BR (1) | BR9607601A (d) |
| CA (1) | CA2203621C (d) |
| CZ (1) | CZ288218B6 (d) |
| DE (1) | DE69629553T2 (d) |
| DK (1) | DK0813417T3 (d) |
| ES (1) | ES2205013T3 (d) |
| HU (1) | HUP9800467A3 (d) |
| IN (1) | IN181358B (d) |
| NO (1) | NO315842B1 (d) |
| NZ (1) | NZ300903A (d) |
| PT (1) | PT813417E (d) |
| TR (1) | TR199700782T1 (d) |
| WO (1) | WO1996025168A1 (d) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2270678C1 (ru) * | 2004-06-30 | 2006-02-27 | Государственное образовательное учреждение высшего профессионального образования Российский государственный медицинский университет Министерства здравоохранения Российской Федерации | Способ лечения хронического цистита у детей |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6475795B1 (en) | 1991-07-03 | 2002-11-05 | Meditech Research, Ltd. | Use of hyaluronan in gene therapy |
| US6548487B2 (en) | 1996-12-27 | 2003-04-15 | Seikagaku Corporation | Agent for treatment of bladder troubles |
| US6232301B1 (en) | 1996-12-27 | 2001-05-15 | Seikagaku Corporation | Remedies for bladder disorders |
| CA2347110C (en) * | 1998-10-22 | 2008-08-26 | Bioniche Life Sciences Inc. | A method for preventing, reducing, and treating radiation cystitis using hyaluronic acid |
| US6083933A (en) * | 1999-04-19 | 2000-07-04 | Stellar International Inc. | Treatment of cystitis-like symptoms with chondroitin sulfate following administration of a challenge solution |
| ES2288883T3 (es) * | 1999-12-13 | 2008-02-01 | Bioniche Life Sciences Inc. | Oligonucleotidos sinteticos utiles terapeuticamente. |
| JP4215429B2 (ja) * | 1999-12-28 | 2009-01-28 | バイオニケ ライフ サイエンシーズ インコーポレイテッド | 癌治療におけるヒアルロン酸 |
| US7504387B2 (en) * | 2002-10-16 | 2009-03-17 | Arthrodynamic Technologies, Animal Health Division, Inc. | Glycosaminoglycan composition and method for treatment and prevention of interstitial cystitis |
| US20040161476A1 (en) | 2003-02-19 | 2004-08-19 | Hahn Sungtack Samuel | Cystitis treatment with high dose chondroitin sulfate |
| WO2006076663A2 (en) * | 2005-01-14 | 2006-07-20 | Urigen, Inc. | Kits and improved compositions for treating lower urinary tract |
| DE102006060953A1 (de) * | 2006-12-12 | 2008-08-07 | Farco-Pharma Gmbh | Pharmazeutische Zubereitung für die Behandlung entzündlicher Erkrankungen des Urogenitaltraktes |
| US8343942B2 (en) * | 2008-04-04 | 2013-01-01 | University Of Utah Research Foundation | Methods for treating interstitial cystitis |
| TWI516269B (zh) | 2009-08-14 | 2016-01-11 | 禾伸堂生技股份有限公司 | 使用於炎症性腸疾病（ｉｂｄ）治療和預防之透明質酸混合物 |
| TWI383796B (zh) | 2009-08-14 | 2013-02-01 | Holy Stone Healthcare Co Ltd | Use of hyaluronic acid mixture for the treatment and prevention of peptic ulcer and duodenal ulcer |
| HUP0900717A3 (en) * | 2009-11-18 | 2012-02-28 | Richter Gedeon Nyrt | Pharmaceutical composition for urological use containing zinc hyaluronate |
| US20110166098A1 (en) * | 2010-01-04 | 2011-07-07 | Wu Tsung-Chung | Mixture of hyaluronic acid for treating and preventing inflammatory bowel disease |
| US8722644B2 (en) | 2010-01-04 | 2014-05-13 | Holy Stone Healthcare Co., Ltd. | Mixture of hyaluronic acid for treating and preventing peptic ulcer and duodenal ulcer |
| US8575130B2 (en) * | 2010-01-04 | 2013-11-05 | Holy Stone Healthcare Co., Ltd. | Mixture of hyaluronic acid for treating and preventing inflammatory bowel disease |
| US8449512B2 (en) | 2010-04-09 | 2013-05-28 | Davinci Biomedical Research Products Inc. | Stoma stabilitating device and method |
| US9029347B2 (en) | 2010-08-05 | 2015-05-12 | Holy Stone Healthcare Co., Ltd. | Method and mixture for treating and preventing inflammatory bowel disease |
| ES2665254T3 (es) * | 2011-07-12 | 2018-04-25 | Holy Stone Healthcare Co., Ltd. | Composiciones que comprenden ácido hialurónico para tratamiento y prevención de enfermedades relacionadas con las mucosas |
| ITMI20111732A1 (it) * | 2011-09-27 | 2013-03-28 | Bsdpharma Srl | Formulazioni farmaceutiche per la riduzione della sensibilizzazione crociata tra colon-retto ed il distretto urogenitale con mezzi non-farmacologici. |
| RU2519010C1 (ru) * | 2013-03-20 | 2014-06-10 | Общество с ограниченной ответственностью "КОЛЕТЕКС" | Композиция для лечения цистита |
| WO2015018461A1 (fr) | 2013-08-09 | 2015-02-12 | Genbiotech | Compositions therapeutiques comprenant d'acide hyaluronique |
| CN103655601B (zh) * | 2013-12-31 | 2019-10-25 | 上海建华精细生物制品有限公司 | 一种用于膀胱灌洗的组合物 |
| CN103861091B (zh) * | 2014-03-20 | 2016-04-27 | 辽宁亿灵科创生物医药科技有限公司 | 治疗膀胱炎的药物组合物 |
| WO2015154007A1 (en) * | 2014-04-03 | 2015-10-08 | Lipella Pharmaceuticals, Inc. | Systems and methods of detecting interstitial cystitis |
| US20160045623A1 (en) | 2015-04-03 | 2016-02-18 | Lipella Pharmaceuticals, Inc. | Systems and Methods to Image Intercellular and Intercompartmental Defects with Magnetic Resonance Imaging (MRI) |
| RU2557949C1 (ru) * | 2014-08-14 | 2015-07-27 | Общество с ограниченной ответственностью "КОЛЕТЕКС" | Способ лечения лучевого и интерстициального цистита |
| GB201616838D0 (en) * | 2016-10-04 | 2016-11-16 | Nat Univ Ireland | Hyaluronan compositions, and uses thereof in treatment of interstitial cystitis |
| EP3400951B1 (de) * | 2017-05-12 | 2019-12-11 | Farco-Pharma GmbH | Blaseninstillationszusammensetzung enthaltend chondoitinsulfat (4,5 mg/ml), hyaluronsäure (16 mg/ml) und phosphatpuffer (ph 6,1 bis 7,9) mit erhöhter lagerstabiliät zur behandlung von cystitis |
| IT201900019762A1 (it) * | 2019-10-24 | 2021-04-24 | Fidia Farm Spa | Composizione farmaceutica per uso nel trattamento della cistite di varia eziologia |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4141973A (en) * | 1975-10-17 | 1979-02-27 | Biotrics, Inc. | Ultrapure hyaluronic acid and the use thereof |
| US4296104A (en) * | 1979-08-30 | 1981-10-20 | Herschler R J | Therapeutic dimethyl sulfoxide composition and methods of use |
| US4302577A (en) * | 1979-10-05 | 1981-11-24 | Biomed Research Inc. | Process for preparing CSA or CSC |
| US5180715A (en) * | 1980-11-17 | 1993-01-19 | The Regents Of The University Of California | Irrigation of internal bladder surfaces in mammals with sodium pentosanpolysulfate |
| DE3118588C2 (de) * | 1981-05-11 | 1983-07-07 | Luitpold-Werk, Chemisch-Pharmazeutische Fabrik, 8000 München | Verfahren zur Herstellung eines injizierbaren hochreinen Chondroitinpolysulfates, hiernach erhältliches Produkt und pharmazeutische Zusammensetzung |
| US4640912A (en) * | 1983-06-09 | 1987-02-03 | Hausman Marvin S | Administration of "active" chondroitin sulfate A and "active" chondroitin sulfate C or mixtures thereof to mammals including humans |
| US4711780A (en) * | 1984-06-11 | 1987-12-08 | Fahim Mostafa S | Composition and process for promoting epithelial regeneration |
| US4820693A (en) * | 1986-05-22 | 1989-04-11 | Angiogenics, Ltd. | Method and composition for arresting angiogenesis and capillary, cell or membrane leakage |
| US4966890A (en) * | 1986-04-04 | 1990-10-30 | Angiogenics, Ltd. | Method and composition for arresting angiogenesis and capillary, cell or membrane leakage |
| US5037810A (en) * | 1987-03-17 | 1991-08-06 | Saliba Jr Michael J | Medical application for heparin and related molecules |
| US4879282A (en) * | 1987-03-17 | 1989-11-07 | Saliba Jr Michael J | Medical application for heparin and related molecules |
| ES2150427T3 (es) * | 1992-06-02 | 2000-12-01 | Bard Inc C R | Procedimiento y dispositivo de implante para el suministro de farmacos a largo plazo. |
| US5633001A (en) * | 1993-03-19 | 1997-05-27 | Medinvent | Composition and a method for tissue augmentation |
-
1996
- 1996-02-13 IN IN262CA1996 patent/IN181358B/en unknown
- 1996-02-14 KR KR1019970705648A patent/KR100268660B1/ko not_active Expired - Fee Related
- 1996-02-14 EP EP96901681A patent/EP0813417B1/en not_active Expired - Lifetime
- 1996-02-14 CN CN96192529A patent/CN1181016A/zh active Pending
- 1996-02-14 TR TR97/00782T patent/TR199700782T1/xx unknown
- 1996-02-14 AT AT96901681T patent/ATE247476T1/de active
- 1996-02-14 PT PT96901681T patent/PT813417E/pt unknown
- 1996-02-14 ES ES96901681T patent/ES2205013T3/es not_active Expired - Lifetime
- 1996-02-14 DK DK96901681T patent/DK0813417T3/da active
- 1996-02-14 CA CA002203621A patent/CA2203621C/en not_active Expired - Lifetime
- 1996-02-14 DE DE69629553T patent/DE69629553T2/de not_active Expired - Lifetime
- 1996-02-14 AU AU46179/96A patent/AU705289B2/en not_active Expired
- 1996-02-14 JP JP52454596A patent/JP4354528B2/ja not_active Expired - Lifetime
- 1996-02-14 BR BR9607601-1A patent/BR9607601A/pt not_active Application Discontinuation
- 1996-02-14 NZ NZ300903A patent/NZ300903A/xx not_active IP Right Cessation
- 1996-02-14 CZ CZ19972574A patent/CZ288218B6/cs not_active IP Right Cessation
- 1996-02-14 WO PCT/CA1996/000094 patent/WO1996025168A1/en active IP Right Grant
- 1996-02-14 HU HU9800467A patent/HUP9800467A3/hu unknown
- 1996-05-13 US US08/644,438 patent/US5888986A/en not_active Expired - Lifetime
-
1997
- 1997-08-13 NO NO19973732A patent/NO315842B1/no not_active IP Right Cessation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2270678C1 (ru) * | 2004-06-30 | 2006-02-27 | Государственное образовательное учреждение высшего профессионального образования Российский государственный медицинский университет Министерства здравоохранения Российской Федерации | Способ лечения хронического цистита у детей |
Also Published As
| Publication number | Publication date |
|---|---|
| HUP9800467A2 (hu) | 1998-06-29 |
| NZ300903A (en) | 1999-07-29 |
| CZ257497A3 (cs) | 1998-01-14 |
| MX9706182A (es) | 1998-07-31 |
| ES2205013T3 (es) | 2004-05-01 |
| BR9607601A (pt) | 1999-09-14 |
| AU4617996A (en) | 1996-09-04 |
| CZ288218B6 (en) | 2001-05-16 |
| PT813417E (pt) | 2003-12-31 |
| KR19980702251A (ko) | 1998-07-15 |
| CA2203621A1 (en) | 1996-08-22 |
| HUP9800467A3 (en) | 1999-01-28 |
| DE69629553T2 (de) | 2004-06-17 |
| NO315842B1 (no) | 2003-11-03 |
| DK0813417T3 (da) | 2003-11-03 |
| US5888986A (en) | 1999-03-30 |
| JP4354528B2 (ja) | 2009-10-28 |
| KR100268660B1 (ko) | 2000-10-16 |
| NO973732L (no) | 1997-10-10 |
| IN181358B (d) | 1998-05-30 |
| ATE247476T1 (de) | 2003-09-15 |
| AU705289B2 (en) | 1999-05-20 |
| TR199700782T1 (xx) | 1998-03-21 |
| JPH10513476A (ja) | 1998-12-22 |
| DE69629553D1 (de) | 2003-09-25 |
| EP0813417A1 (en) | 1997-12-29 |
| EP0813417B1 (en) | 2003-08-20 |
| NO973732D0 (no) | 1997-08-13 |
| WO1996025168A1 (en) | 1996-08-22 |
| CN1181016A (zh) | 1998-05-06 |
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Legal Events
| Date | Code | Title | Description |
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| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20160215 |