CA2173844A1 - Chelateurs n-alkylpeptidiques, leurs complexes metalliques avec des radionucleides, procedes pour leur preparation et compositions radiopharmaceutiques contenant ces composes - Google Patents
Chelateurs n-alkylpeptidiques, leurs complexes metalliques avec des radionucleides, procedes pour leur preparation et compositions radiopharmaceutiques contenant ces composesInfo
- Publication number
- CA2173844A1 CA2173844A1 CA002173844A CA2173844A CA2173844A1 CA 2173844 A1 CA2173844 A1 CA 2173844A1 CA 002173844 A CA002173844 A CA 002173844A CA 2173844 A CA2173844 A CA 2173844A CA 2173844 A1 CA2173844 A1 CA 2173844A1
- Authority
- CA
- Canada
- Prior art keywords
- general formula
- group
- compounds
- residue
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- C07D457/06—Lysergic acid amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/26—Esters of monothiocarboxylic acids having carbon atoms of esterified thiocarboxyl groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
- C07D457/12—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57536—Endothelin, vasoactive intestinal contractor [VIC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
L'invention concerne des chélateurs N-alkylpeptidiques, leurs complexes métalliques avec des radionucléides, des procédés pour leur préparation et des compositions radiopharmaceutiques contenant ces composés. L'invention concerne également des produits radiopharmaceutiques contenant ces chélates sous une forme complexée avec des métaux, des trousses de diagnostic dans lesquelles le chélate peut se présenter sous une forme non complexée et être complexé par addition d'ions technétium ou rhénium, et elle concerne également l'utilisation de ces préparations à des fins diagnostiques et thérapeutiques.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4337600A DE4337600A1 (de) | 1993-11-01 | 1993-11-01 | N-Alkyl-Peptidchelatbildner, deren Metallkomplexe mit Radionukliden, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende radiopharmazeutische Zusammesetzungen |
DEP4337600.2 | 1993-11-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2173844A1 true CA2173844A1 (fr) | 1995-05-11 |
Family
ID=6501750
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002173844A Abandoned CA2173844A1 (fr) | 1993-11-01 | 1994-10-27 | Chelateurs n-alkylpeptidiques, leurs complexes metalliques avec des radionucleides, procedes pour leur preparation et compositions radiopharmaceutiques contenant ces composes |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0726909A1 (fr) |
JP (1) | JPH09508351A (fr) |
KR (1) | KR960705842A (fr) |
CN (1) | CN1134158A (fr) |
AU (1) | AU681919B2 (fr) |
CA (1) | CA2173844A1 (fr) |
DE (1) | DE4337600A1 (fr) |
HU (1) | HUT74881A (fr) |
NO (1) | NO961743L (fr) |
WO (1) | WO1995012610A1 (fr) |
ZA (1) | ZA948411B (fr) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6241963B1 (en) * | 1995-10-19 | 2001-06-05 | The Trustees Of The University Of Pennsylvania | Dopamine and serotonin transporter ligands and imaging agents |
US6162378A (en) * | 1999-02-25 | 2000-12-19 | 3D Systems, Inc. | Method and apparatus for variably controlling the temperature in a selective deposition modeling environment |
US6171578B1 (en) | 1999-04-14 | 2001-01-09 | Diatide, Inc. | Benzodiazepine derivatives for imaging thrombi |
CN100494182C (zh) * | 2000-05-12 | 2009-06-03 | 基酶有限公司 | 肿瘤坏死α因子信号的调节因子 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA811340B (en) * | 1980-06-09 | 1982-03-31 | Morton Norwich Products Inc | N-(cycloalkyl)amino acid compounds |
WO1992019274A1 (fr) * | 1991-05-08 | 1992-11-12 | Mallinckrodt Medical, Inc. | Chelates de technetium utilisables pour l'examen de la fonction renale |
JPH0570484A (ja) * | 1991-09-12 | 1993-03-23 | Hitachi Chem Co Ltd | ペプチドおよびその塩 |
WO1993015771A1 (fr) * | 1992-02-06 | 1993-08-19 | Mallinckrodt Medical, Inc. | Ligands permettant d'ameliorer la cinetique de formation d'agents chelateurs |
ATE196094T1 (de) * | 1992-05-21 | 2000-09-15 | Diatide Inc | Technetium-99m markierte peptide zur bilderzeugung von thrombus |
DE4311021A1 (de) * | 1993-03-31 | 1994-10-27 | Diagnostikforschung Inst | Bifunktionelle Chelatbildner, deren Technetium- und Rhenium-Komplexe, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende radiopharmazeutische Mittel |
-
1993
- 1993-11-01 DE DE4337600A patent/DE4337600A1/de not_active Withdrawn
-
1994
- 1994-10-26 ZA ZA948411A patent/ZA948411B/xx unknown
- 1994-10-27 WO PCT/DE1994/001295 patent/WO1995012610A1/fr not_active Application Discontinuation
- 1994-10-27 CN CN94193990A patent/CN1134158A/zh active Pending
- 1994-10-27 CA CA002173844A patent/CA2173844A1/fr not_active Abandoned
- 1994-10-27 JP JP7512959A patent/JPH09508351A/ja active Pending
- 1994-10-27 EP EP95900059A patent/EP0726909A1/fr not_active Withdrawn
- 1994-10-27 HU HU9601140A patent/HUT74881A/hu unknown
- 1994-10-27 AU AU81038/94A patent/AU681919B2/en not_active Ceased
-
1996
- 1996-04-30 KR KR1019960702247A patent/KR960705842A/ko not_active Application Discontinuation
- 1996-04-30 NO NO961743A patent/NO961743L/no unknown
Also Published As
Publication number | Publication date |
---|---|
ZA948411B (en) | 1995-06-30 |
DE4337600A1 (de) | 1995-05-04 |
KR960705842A (ko) | 1996-11-08 |
EP0726909A1 (fr) | 1996-08-21 |
NO961743D0 (no) | 1996-04-30 |
CN1134158A (zh) | 1996-10-23 |
WO1995012610A1 (fr) | 1995-05-11 |
HUT74881A (en) | 1997-02-28 |
AU681919B2 (en) | 1997-09-11 |
JPH09508351A (ja) | 1997-08-26 |
AU8103894A (en) | 1995-05-23 |
HU9601140D0 (en) | 1996-07-29 |
NO961743L (no) | 1996-04-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDE | Dead |