CA2170253A1 - Pharmaceutical compositions comprising metal complexes - Google Patents

Pharmaceutical compositions comprising metal complexes

Info

Publication number
CA2170253A1
CA2170253A1 CA002170253A CA2170253A CA2170253A1 CA 2170253 A1 CA2170253 A1 CA 2170253A1 CA 002170253 A CA002170253 A CA 002170253A CA 2170253 A CA2170253 A CA 2170253A CA 2170253 A1 CA2170253 A1 CA 2170253A1
Authority
CA
Canada
Prior art keywords
formula
complex
medicament
disease
manufacture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002170253A
Other languages
English (en)
French (fr)
Inventor
Michael Jeffrey Abrams
Simon Paul Fricker
Barry Anthony Murrer
Owen John Vaughan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Anormed Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2170253A1 publication Critical patent/CA2170253A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Inorganic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA002170253A 1993-08-25 1994-08-19 Pharmaceutical compositions comprising metal complexes Abandoned CA2170253A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9317686.5 1993-08-25
GB939317686A GB9317686D0 (en) 1993-08-25 1993-08-25 Pharmaceutical compositions

Publications (1)

Publication Number Publication Date
CA2170253A1 true CA2170253A1 (en) 1995-03-02

Family

ID=10741021

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002170253A Abandoned CA2170253A1 (en) 1993-08-25 1994-08-19 Pharmaceutical compositions comprising metal complexes

Country Status (14)

Country Link
US (1) US5824673A (enExample)
EP (1) EP0714294A1 (enExample)
JP (1) JPH09501927A (enExample)
KR (1) KR100331978B1 (enExample)
AU (1) AU698785B2 (enExample)
CA (1) CA2170253A1 (enExample)
FI (1) FI960849A0 (enExample)
GB (1) GB9317686D0 (enExample)
HU (1) HUT74947A (enExample)
NO (1) NO960754L (enExample)
NZ (1) NZ269596A (enExample)
TW (1) TW282401B (enExample)
WO (1) WO1995005814A1 (enExample)
ZA (1) ZA946262B (enExample)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6417182B1 (en) * 1993-08-25 2002-07-09 Anormed Inc. Pharmaceutical compositions comprising metal complexes
ES2238074T3 (es) * 1994-05-11 2005-08-16 Jes Olesen Uso de depuradores, inhibidores o antagonistas de no en el tratamiento de la migraña.
NZ285648A (en) * 1994-05-13 1999-08-30 Monsanto Co Use of a metal complex as a metal peroxynitrite decomposition catalyst to treat diseases which are affected by accelerated decomposition of peroxynitrite
US6245758B1 (en) 1994-05-13 2001-06-12 Michael K. Stern Methods of use for peroxynitrite decomposition catalysts, pharmaceutical compositions therefor
US6743771B2 (en) * 1995-12-29 2004-06-01 Novactyl, Inc. Methods and compositions for controlling protein assembly or aggregation
US20030013772A1 (en) * 2000-02-23 2003-01-16 Murphy Michael A. Composition, synthesis and therapeutic applications of polyamines
DE19860289C2 (de) 1998-12-21 2003-11-13 Schering Ag Neue Chelatoren sowie deren Tricarbonyl-Komplexe mit Technetium und Rhenium
CA2367282A1 (en) * 1999-03-19 2000-09-28 Simon Fricker Pharmaceutical compositions comprising metal complexes
EP1212459A2 (en) * 1999-08-25 2002-06-12 Clarity Biosciences, Inc. Identifying organisms by detecting intronic nucleic acid or encoded proteins
US7335383B2 (en) * 2001-01-16 2008-02-26 The Regents Of The University Of Michigan Generation of nitric oxide in vivo from nitrite, nitrate or nitrosothiols endogenous in blood
US7128904B2 (en) * 2001-01-16 2006-10-31 The Regents Of The University Of Michigan Material containing metal ion ligand complex producing nitric oxide in contact with blood
EP1370679B1 (en) * 2001-03-01 2011-10-05 Clarity Biosciences, Inc. Methods of making and uses of compositions that modulate intronic region-encoded protein function
GB0111872D0 (en) * 2001-05-15 2001-07-04 Northwick Park Inst For Medica Therapeutic agents and methods
EP2319518A1 (en) * 2002-02-04 2011-05-11 ALFAMA-Investigacao e Desenvolvimento de Produtos Farmaceuticos Lda. Use of CO-releasing compounds for the manufacture of a medicament for the treatment of inflammatory diseases
US7968605B2 (en) * 2002-02-04 2011-06-28 ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda. Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
US20080026984A1 (en) * 2002-02-04 2008-01-31 Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
GB2395432B (en) * 2002-11-20 2005-09-14 Northwick Park Inst For Medica Therapeutic delivery of carbon monoxide to extracorporeal and isolated organs
US20070207217A1 (en) * 2003-02-03 2007-09-06 Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda Method for treating a mammal by administration of a compound having the ability to release CO
CN1318430C (zh) * 2003-04-24 2007-05-30 钟文远 一类稀土配合物及其制备方法和在制备治疗肿瘤药物中的应用
KR20060125790A (ko) * 2003-11-07 2006-12-06 가부시키가이샤 시테크 뇌경색의 예방 및/또는 치료를 위한 의약
US20060008529A1 (en) * 2004-07-12 2006-01-12 Meyerhoff Mark E Use of additive sites to control nitric oxide release from nitric oxide donors contained within polymers
US20060039950A1 (en) * 2004-08-23 2006-02-23 Zhengrong Zhou Multi-functional biocompatible coatings for intravascular devices
WO2007005758A2 (en) * 2005-06-30 2007-01-11 Mc3, Inc. Methods , compositions and devices for promoting angiogenesis
CN101378792A (zh) * 2005-12-02 2009-03-04 密执安大学评议会 聚合物组合物、涂层和装置及其制备和使用方法
GB0601394D0 (en) 2006-01-24 2006-03-01 Hemocorm Ltd Therapeutic delivery of carbon monoxide
US20080119002A1 (en) * 2006-11-17 2008-05-22 Charles Grosjean Substrate contact for a MEMS device
US8597563B2 (en) 2008-07-11 2013-12-03 Rohm And Haas Company Recycled thermoplastic composition comprising waste thermoset material and methods of making
DE102010014412A1 (de) 2010-04-08 2012-04-19 Friedrich-Schiller-Universität Jena Verwendung von zweikernigen Eisenkomplexen mit schwefelhaltigen Liganden als pharmakologische Wirkstoffe
DE102010014411A1 (de) 2010-04-08 2011-10-13 Friedrich-Schiller-Universität Jena Kohlenmonoxid und Eisen freisetzende Moleküle, deren Verwendung und Verfahren zu deren Herstellung
WO2012138988A2 (en) * 2011-04-07 2012-10-11 The Research Foundation Of The City University Of New York Organometallic anti-cancer complexes
PT2699242T (pt) 2011-04-19 2018-01-22 Alfama Inc Moléculas de libertação de monóxido de carbono e utilizações das mesmas
ES2628634T3 (es) 2011-07-21 2017-08-03 Alfama, Inc. Moléculas liberadoras de monóxido de carbono-rutenio y usos de las mismas
DE102012004132A1 (de) 2012-02-29 2013-08-29 Friedrich-Schiller-Universität Jena Kohlenstoffmonoxid freisetzende Materialien und deren Verwendung
DE102014008537A1 (de) 2014-06-04 2015-12-17 Friedrich-Schiller-Universität Jena Wasserlösliche manganbasierte Kohlenstoffmonoxid freisetzende Moleküle, deren Verwendung und Verfahren zu deren Herstellung

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1482811A (fr) * 1960-01-26 1967-06-02 Australian Nat University Pers Nouveaux complexes métallifères d'agents de coordination homogènes, et leur procédé de préparation
AU570826B2 (en) * 1984-07-24 1988-03-24 Asta-Pharma Aktiengesellschaft Ruthenium compounds having a tumor inhibiting activity
WO1986000804A1 (fr) * 1984-07-24 1986-02-13 Byk Gulden Lomberg Chemische Fabrik Gesellschaft M Compositions de ruthenium a effet inhibiteur de tumeurs
US5157032A (en) * 1985-01-18 1992-10-20 The Trustees Of Columbia University In The City Of New York Mixed ligand complexes and uses thereof as binding agents and probes to DNA
IT1230145B (it) * 1989-05-05 1991-10-14 Boehringer Biochemia Srl Complessi di rutenio (iii) come agenti antineoplastici.

Also Published As

Publication number Publication date
NO960754L (no) 1996-04-23
HU9600441D0 (en) 1996-04-29
AU698785B2 (en) 1998-11-05
KR100331978B1 (ko) 2002-09-26
ZA946262B (en) 1995-03-20
FI960849L (fi) 1996-02-23
EP0714294A1 (en) 1996-06-05
US5824673A (en) 1998-10-20
NO960754D0 (no) 1996-02-23
AU7390794A (en) 1995-03-21
HUT74947A (en) 1997-03-28
JPH09501927A (ja) 1997-02-25
FI960849A7 (fi) 1996-02-23
FI960849A0 (fi) 1996-02-23
NZ269596A (en) 1997-05-26
KR960703609A (ko) 1996-08-31
WO1995005814A1 (en) 1995-03-02
TW282401B (enExample) 1996-08-01
GB9317686D0 (en) 1993-10-13

Similar Documents

Publication Publication Date Title
US6417182B1 (en) Pharmaceutical compositions comprising metal complexes
US5824673A (en) Pharmaceutical compositions comprising metal complexes
Glaumann et al. Studies on the pathogenesis of ischemic cell injury: II. Morphological changes of the pars convoluta (P1 and P2) of the proximal tubule of the rat kidney made ischemic in vivo
US6284752B1 (en) Pharmaceutical compositions comprising metal complexes
US4952607A (en) Copper complex for treating cancer
CN1228703A (zh) 用于治疗由自由基引发的疾病的螯合剂及其金属螯合物
EP4126905A1 (en) Cyclophilin inhibitors and uses thereof
US9511053B2 (en) Nitric oxide scavengers
EP0643969A2 (en) Pharmaceutical composition for renal disorder and a dialysis solution for extracorporeal hemodialysis
US20020193363A1 (en) Use of nitric oxide scavengers to modulate inflammation and matrix metalloproteinase activity
Durbin et al. Specific Sequestering Agents for the Actinides: 4. Removal of 238Pu (IV) from Mice by Sulfonated Tetrameric Catechoyl Amides
WO1984004922A1 (en) Copper complex for treating cancer
EP0278681B1 (en) An antihepatopathic composition
ES2595368T3 (es) Nueva composición para el tratamiento de pigmentaciones equimóticas
Selleck et al. Specific localization of α-ketoglutarate uptake to dog kidney and liver in vivo
Lieberman et al. Hepatic blood supply and control of deoxyribonucleic acid synthesis in liver
US5338759A (en) Vanadyl complexes of hydroxamate chelators and pharmaceutical compositions comprising them
KR20240091298A (ko) 마그놀롤 및/또는 호노키올 방향족 고리 아미노 치환계 유도체의 항-저산소/무산소 손상 용도 및 약학적 조성물
Roomi et al. Suppression of growth and hepatic metastasis of murine B16FO melanoma cells by a novel nutrient mixture
Hawking et al. The antifilarial action and toxicity of methylene violet and of other compounds of the phenosafranine series
Meyer-Brunot et al. Biliary excretion of ferrioxamines of varying liposolubility in perfused rat liver
RU2849642C2 (ru) Применение аминозамещенного производного магнололового и/или хонокиолового ароматического кольца против гипоксического/аноксического повреждения и фармацевтическая композиция
CN113929735B (zh) Gly-Pro-Arg-Pro-NHCH2CH2NH-华法林,其合成,活性和应用
SU596240A1 (ru) Способ получени фибринолитического комплекса
Yamaguchi et al. Studies on morphological changes of arteries by administration of soluble immune complexes to low calcium diet bred guinea pigs—Special reference to the morphological pathogenesis of arteritis

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued