CA2168099A1 - Benzoxazinones and benzothiazinones endowed with therapeutic activity - Google Patents

Benzoxazinones and benzothiazinones endowed with therapeutic activity

Info

Publication number
CA2168099A1
CA2168099A1 CA002168099A CA2168099A CA2168099A1 CA 2168099 A1 CA2168099 A1 CA 2168099A1 CA 002168099 A CA002168099 A CA 002168099A CA 2168099 A CA2168099 A CA 2168099A CA 2168099 A1 CA2168099 A1 CA 2168099A1
Authority
CA
Canada
Prior art keywords
alkyl
mole
benzoxazin
dihydro
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002168099A
Other languages
English (en)
French (fr)
Inventor
Silvio Levi
Francesca Benedini
Giorgio Bertolini
Gianni Gromo
Jacques Mizrhai
Alberto Sala
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Italfarmaco SpA
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2168099A1 publication Critical patent/CA2168099A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/20—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 4
    • C07D265/22—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
    • C07D279/08—1,3-Thiazines; Hydrogenated 1,3-thiazines condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA002168099A 1993-07-28 1994-07-18 Benzoxazinones and benzothiazinones endowed with therapeutic activity Abandoned CA2168099A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI93A001678 1993-07-28
IT93MI001678A IT1264812B1 (it) 1993-07-28 1993-07-28 Derivati benzossazinonici e benzotiazinonici terapeuticamente attivi

Publications (1)

Publication Number Publication Date
CA2168099A1 true CA2168099A1 (en) 1995-02-09

Family

ID=11366700

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002168099A Abandoned CA2168099A1 (en) 1993-07-28 1994-07-18 Benzoxazinones and benzothiazinones endowed with therapeutic activity

Country Status (13)

Country Link
EP (1) EP0711286A1 (cs)
JP (1) JPH09500878A (cs)
CN (1) CN1128025A (cs)
AU (1) AU7494594A (cs)
CA (1) CA2168099A1 (cs)
FI (1) FI960342A7 (cs)
HU (1) HUT74587A (cs)
IL (1) IL110473A0 (cs)
IT (1) IT1264812B1 (cs)
NO (1) NO960308L (cs)
TW (1) TW277061B (cs)
WO (1) WO1995004048A1 (cs)
ZA (1) ZA945555B (cs)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6509334B1 (en) 1999-05-04 2003-01-21 American Home Products Corporation Cyclocarbamate derivatives as progesterone receptor modulators
CN102367239B (zh) * 2011-07-20 2015-10-28 沈阳药科大学 2-芳基-2,3-二氢-4h-1,3-苯并噻嗪-4-酮衍生物及其用途
EP2887939B1 (en) * 2012-08-27 2018-04-11 University of Tennessee Research Foundation Lpa2 receptor-specific benzoic acid derivatives
ITMI20122221A1 (it) * 2012-12-21 2014-06-22 C4T S C A R L Nuovi composti del 2,3-diidro-4h-1,3-benzossazin-4-one, metodo per prepararli e forma farmaceutica che li comprende
ES2691541T3 (es) * 2013-12-19 2018-11-27 Gilead Sciences, Inc. Compuestos heterocíclicos condensados como moduladores de canales iónicos

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2443M (fr) * 1962-10-30 1964-04-06 Selvi & C Lab Bioterapico Thio-dérivés de benzo-oxazine ayant des propriétés antiphlogistiques, antipyrétiques et analgésiques.
US3459748A (en) * 1967-04-28 1969-08-05 Squibb & Sons Inc Hydroxyalkylene-substituted benzoxazines and benzothiazines
IT1136575B (it) * 1981-04-15 1986-09-03 Coli Farma Lab Esteri del 2-(2-ossietil)-2,3-diidro-h4-1,3-benzossazin-4-one ad attivita' analgesica e procedimento per la loro preparazione
IT1244472B (it) * 1990-12-14 1994-07-15 Italfarmaco Spa Benzossazinoni e benzotiazinoni ad attivita' cardiovascolare
FR2680172B1 (fr) * 1991-08-05 1993-11-19 Fabre Medicament Pierre Nouvelles piperazinylalcoyl-3 dihydro-2,3 4h-benzoxazine-1,3 ones-4 substituees, leur preparation et leur application en therapeutique.
IT1254884B (it) * 1992-04-16 1995-10-11 Italfarmaco Spa Benzossazinoni e benzotiazinoni ad attivita' cardiovascolare

Also Published As

Publication number Publication date
AU7494594A (en) 1995-02-28
ZA945555B (en) 1995-03-03
EP0711286A1 (en) 1996-05-15
FI960342A0 (fi) 1996-01-25
NO960308D0 (no) 1996-01-25
IL110473A0 (en) 1994-10-21
FI960342L (fi) 1996-01-25
HUT74587A (en) 1997-01-28
ITMI931678A1 (it) 1995-01-28
IT1264812B1 (it) 1996-10-10
NO960308L (no) 1996-03-13
ITMI931678A0 (it) 1993-07-28
JPH09500878A (ja) 1997-01-28
WO1995004048A1 (en) 1995-02-09
CN1128025A (zh) 1996-07-31
FI960342A7 (fi) 1996-01-25
HU9600165D0 (en) 1996-03-28
TW277061B (cs) 1996-06-01

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Legal Events

Date Code Title Description
FZDE Discontinued