CA2137377C - Retinal pigmented epithelium derived neurotrophic factor - Google Patents
Retinal pigmented epithelium derived neurotrophic factor Download PDFInfo
- Publication number
- CA2137377C CA2137377C CA2137377A CA2137377A CA2137377C CA 2137377 C CA2137377 C CA 2137377C CA 2137377 A CA2137377 A CA 2137377A CA 2137377 A CA2137377 A CA 2137377A CA 2137377 C CA2137377 C CA 2137377C
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- Prior art keywords
- pednf
- cells
- polypeptide
- protein fraction
- ammonium sulfate
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- Expired - Lifetime
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Tropical Medicine & Parasitology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Communicable Diseases (AREA)
- Emergency Medicine (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89421592A | 1992-06-04 | 1992-06-04 | |
| US07/894,215 | 1992-06-04 | ||
| PCT/US1993/005358 WO1993024529A1 (en) | 1992-06-04 | 1993-06-04 | Retinal pigmented epithelium derived neurotrophic factor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2137377A1 CA2137377A1 (en) | 1993-12-09 |
| CA2137377C true CA2137377C (en) | 2011-03-08 |
Family
ID=25402767
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2137377A Expired - Lifetime CA2137377C (en) | 1992-06-04 | 1993-06-04 | Retinal pigmented epithelium derived neurotrophic factor |
Country Status (6)
| Country | Link |
|---|---|
| EP (2) | EP1415994A1 (enExample) |
| JP (3) | JPH07508646A (enExample) |
| AU (1) | AU4406993A (enExample) |
| CA (1) | CA2137377C (enExample) |
| DE (1) | DE69333229T2 (enExample) |
| WO (1) | WO1993024529A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5840686A (en) * | 1992-09-24 | 1998-11-24 | The United States Of America As Represented By The Department Of Health And Human Services | Pigment epithelium-derived factor: characterization of its novel biological activity and sequences encoding and expressing the protein and methods of use |
| US6319687B1 (en) * | 1992-09-24 | 2001-11-20 | The United States Of America As Represented By The Department Of Health And Human Services | Pigment epithelium-derived factor: characterization, genomic organization and sequence of PEDF gene |
| US6451763B1 (en) * | 1992-06-04 | 2002-09-17 | The United States Of America As Represented By The Department Of Health And Human Services | Retinal pigmented epithelium derived neurotrophic factor and methods of use |
| US6472585B1 (en) | 1994-04-25 | 2002-10-29 | Genentech, Inc. | Cardiotrophin-1 defective mouse |
| EP0755446B1 (en) * | 1994-04-25 | 2006-09-13 | Genentech, Inc. | Cardiotrophin and uses therefor |
| US5534615A (en) * | 1994-04-25 | 1996-07-09 | Genentech, Inc. | Cardiac hypertrophy factor and uses therefor |
| US7258983B2 (en) | 1994-04-25 | 2007-08-21 | Genentech, Inc. | Cardiotrophin-1 compositions and methods for the treatment of tumor |
| US5804376A (en) * | 1995-05-02 | 1998-09-08 | Incyte Pharmaceuticals, Inc. | Pancreas-derived serpin |
| US7105496B2 (en) | 1998-07-23 | 2006-09-12 | Northwestern University | Methods and compositions for inhibiting angiogenesis |
| WO1999004806A1 (en) | 1997-07-23 | 1999-02-04 | Northwestern University | Methods and compositions for inhibiting angiogenesis |
| US6797691B1 (en) | 1997-07-23 | 2004-09-28 | Northwestern University | Methods and compositions for inhibiting angiogenesis |
| US6821775B1 (en) | 2000-02-11 | 2004-11-23 | Genvec, Inc. | Viral vector encoding pigment epithelium-derived factor |
| DE60136444D1 (de) * | 2000-02-23 | 2008-12-18 | Univ Northwestern | Pharmazeutische zusammensetzung zur angiogenese-hemmung mittels eines pedf-fragmentes |
| US20030158112A1 (en) | 2002-02-15 | 2003-08-21 | Johns Hopkins University School Of Medicine | Selective induction of apoptosis to treat ocular disease |
| US20040166091A1 (en) | 2003-02-24 | 2004-08-26 | Genvec, Inc. | Materials and methods for treating disorders of the ear |
| WO2006046584A1 (ja) * | 2004-10-26 | 2006-05-04 | Santen Pharmaceutical Co., Ltd. | 視細胞障害治療剤 |
| WO2006054278A2 (en) * | 2004-11-16 | 2006-05-26 | Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science | Variants of pigment epithelium derived factor and uses thereof |
| WO2006064512A1 (en) * | 2004-12-13 | 2006-06-22 | Unichem Laboratories Limited | A process of fractionating and storing proteins |
| CA2629519A1 (en) | 2005-11-14 | 2007-05-18 | Yeda Research & Development Co. Ltd. At The Weizmann Institute Of Scienc E | Improved variants of pigment epithelium derived factor and uses thereof |
| US9938328B2 (en) * | 2012-09-17 | 2018-04-10 | Mackay Memorial Hospital | Use of PEDF-derived polypeptides for treating alopecia and/or hair depigmentation |
| TWI710635B (zh) | 2014-10-09 | 2020-11-21 | 美商珍維克公司 | 編碼人類無調同源物-1(hath1)之腺病毒載體 |
| JP6522063B2 (ja) * | 2017-08-10 | 2019-05-29 | マクカイ メモリアル ホスピタル | 脱毛症及び／又は毛髪色素脱失を治療するためのｐｅｄｆ由来のポリペプチドの使用 |
| JP7575787B2 (ja) * | 2018-09-27 | 2024-10-30 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 細胞に基づく治療または処置のためのアッセイ |
| EP3705132A1 (en) * | 2019-03-04 | 2020-09-09 | Curebiotec GmbH | Method for the treatment of a disease using pigment epithelium-derived factor (pedf) |
| CN114981298B (zh) | 2019-12-12 | 2024-08-20 | 听治疗有限责任公司 | 用于预防和治疗听力损失的组合物和方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5229500A (en) * | 1989-08-30 | 1993-07-20 | Regeneron Pharmaceuticals, Inc. | Brain derived neurotrophic factor |
-
1993
- 1993-06-04 DE DE69333229T patent/DE69333229T2/de not_active Expired - Lifetime
- 1993-06-04 JP JP6500883A patent/JPH07508646A/ja not_active Withdrawn
- 1993-06-04 CA CA2137377A patent/CA2137377C/en not_active Expired - Lifetime
- 1993-06-04 EP EP20030022103 patent/EP1415994A1/en not_active Ceased
- 1993-06-04 AU AU44069/93A patent/AU4406993A/en not_active Abandoned
- 1993-06-04 EP EP93914393A patent/EP0662087B1/en not_active Expired - Lifetime
- 1993-06-04 WO PCT/US1993/005358 patent/WO1993024529A1/en not_active Ceased
-
2004
- 2004-06-09 JP JP2004171939A patent/JP2004262947A/ja active Pending
-
2005
- 2005-01-12 JP JP2005005788A patent/JP2005112863A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP0662087B1 (en) | 2003-10-01 |
| WO1993024529A1 (en) | 1993-12-09 |
| EP0662087A1 (en) | 1995-07-12 |
| CA2137377A1 (en) | 1993-12-09 |
| AU4406993A (en) | 1993-12-30 |
| EP0662087A4 (en) | 1997-01-29 |
| JPH07508646A (ja) | 1995-09-28 |
| EP1415994A1 (en) | 2004-05-06 |
| JP2004262947A (ja) | 2004-09-24 |
| DE69333229T2 (de) | 2004-08-12 |
| JP2005112863A (ja) | 2005-04-28 |
| DE69333229D1 (de) | 2003-11-06 |
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