CA2129347A1 - Process of preparing 3-acylandrostadienes - Google Patents

Process of preparing 3-acylandrostadienes

Info

Publication number
CA2129347A1
CA2129347A1 CA002129347A CA2129347A CA2129347A1 CA 2129347 A1 CA2129347 A1 CA 2129347A1 CA 002129347 A CA002129347 A CA 002129347A CA 2129347 A CA2129347 A CA 2129347A CA 2129347 A1 CA2129347 A1 CA 2129347A1
Authority
CA
Canada
Prior art keywords
compound
formula
process according
nitrogen
solvate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002129347A
Other languages
English (en)
French (fr)
Inventor
Neil H. Baine
Michael A. Mcguire
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2129347A1 publication Critical patent/CA2129347A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0066—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by a carbon atom forming part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA002129347A 1992-02-07 1993-02-05 Process of preparing 3-acylandrostadienes Abandoned CA2129347A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US83227992A 1992-02-07 1992-02-07
US07/832,279 1992-02-07
PCT/US1993/001071 WO1993016098A1 (en) 1992-02-07 1993-02-05 Process of preparing 3-acylandrostadienes

Publications (1)

Publication Number Publication Date
CA2129347A1 true CA2129347A1 (en) 1993-08-19

Family

ID=25261205

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002129347A Abandoned CA2129347A1 (en) 1992-02-07 1993-02-05 Process of preparing 3-acylandrostadienes

Country Status (13)

Country Link
EP (1) EP0626972A4 (enExample)
JP (1) JPH07505618A (enExample)
KR (1) KR950700320A (enExample)
CN (1) CN1078474A (enExample)
AU (1) AU3612893A (enExample)
CA (1) CA2129347A1 (enExample)
IL (1) IL104601A0 (enExample)
MA (1) MA22787A1 (enExample)
MX (1) MX9300677A (enExample)
SI (1) SI9300067A (enExample)
TW (1) TW241266B (enExample)
WO (1) WO1993016098A1 (enExample)
ZA (1) ZA93802B (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL104602A (en) * 1992-02-07 1997-07-13 Smithkline Beecham Corp Process for the preparation of 3-carbonylandrostadiene- 17-carboxamides and intermediates for this process
US5683995A (en) * 1992-11-18 1997-11-04 Smithkline Beecham Corporation 17 substituted acyl-3-carboxy 3,5-diene steroidals as α-reductase inhibitors
US5641765A (en) * 1992-11-18 1997-06-24 Smithkline Beecham Corporation 17-αand 17-βsubstituted acyl-3-carboxy-3,5-dienes and use in inhibiting 5-α-reductase

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4946834A (en) * 1988-12-23 1990-08-07 Smithkline Beecham Corporation Phosphonic acid substituted steroids as steroid 5α-reductase inhibitors
US5032586A (en) * 1989-08-24 1991-07-16 Smithkline Beecham Corporation 7-keto or hydroxy 3,5-diene steroids as inhibitors of steroid 5-alpha reductase
US5091380A (en) * 1990-06-28 1992-02-25 Merck & Co., Inc. N-monosubstituted adamantyl/norbornanyl 17β-carbamides of 3-carboxy-androst-3,5-dienes as testosterone 5α-reductase inhibitors

Also Published As

Publication number Publication date
CN1078474A (zh) 1993-11-17
KR950700320A (ko) 1995-01-16
ZA93802B (en) 1993-11-05
JPH07505618A (ja) 1995-06-22
IL104601A0 (en) 1993-07-08
EP0626972A4 (en) 1995-01-04
MA22787A1 (fr) 1993-10-01
TW241266B (enExample) 1995-02-21
WO1993016098A1 (en) 1993-08-19
AU3612893A (en) 1993-09-03
MX9300677A (es) 1994-07-29
SI9300067A (en) 1993-09-30
EP0626972A1 (en) 1994-12-07

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Legal Events

Date Code Title Description
FZDE Discontinued