CA2129112A1 - Derives de benzopyrane, benzothiopyrane et benzofurane, antagonistes de 5-ht4 - Google Patents

Derives de benzopyrane, benzothiopyrane et benzofurane, antagonistes de 5-ht4

Info

Publication number
CA2129112A1
CA2129112A1 CA002129112A CA2129112A CA2129112A1 CA 2129112 A1 CA2129112 A1 CA 2129112A1 CA 002129112 A CA002129112 A CA 002129112A CA 2129112 A CA2129112 A CA 2129112A CA 2129112 A1 CA2129112 A1 CA 2129112A1
Authority
CA
Canada
Prior art keywords
alkyl
hydrogen
compound according
halo
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002129112A
Other languages
English (en)
Inventor
Francis David King
Laramie Mary Gaster
Graham Francis Joiner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929202510A external-priority patent/GB9202510D0/en
Priority claimed from GB929215499A external-priority patent/GB9215499D0/en
Priority claimed from GB929221446A external-priority patent/GB9221446D0/en
Priority claimed from GB929225788A external-priority patent/GB9225788D0/en
Application filed by Individual filed Critical Individual
Publication of CA2129112A1 publication Critical patent/CA2129112A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002129112A 1992-02-06 1993-02-01 Derives de benzopyrane, benzothiopyrane et benzofurane, antagonistes de 5-ht4 Abandoned CA2129112A1 (fr)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
GB9202510.5 1992-02-06
GB929202510A GB9202510D0 (en) 1992-02-06 1992-02-06 Pharmaceuticals
GB929215499A GB9215499D0 (en) 1992-07-21 1992-07-21 Pharmaceuticals
GB9215499.6 1992-07-21
GB929221446A GB9221446D0 (en) 1992-10-13 1992-10-13 Pharmaceuticals
GB9221446.9 1992-10-13
GB9225788.0 1992-12-10
GB929225788A GB9225788D0 (en) 1992-12-10 1992-12-10 Pharmaceuticals

Publications (1)

Publication Number Publication Date
CA2129112A1 true CA2129112A1 (fr) 1993-08-19

Family

ID=27450819

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002129112A Abandoned CA2129112A1 (fr) 1992-02-06 1993-02-01 Derives de benzopyrane, benzothiopyrane et benzofurane, antagonistes de 5-ht4

Country Status (8)

Country Link
EP (1) EP0625149A1 (fr)
JP (1) JPH07503480A (fr)
KR (1) KR950700288A (fr)
AU (1) AU667874B2 (fr)
CA (1) CA2129112A1 (fr)
MX (1) MX9300616A (fr)
NZ (1) NZ246915A (fr)
WO (1) WO1993016072A1 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5998409A (en) * 1992-03-12 1999-12-07 Smithkline Beecham Plc Condensed indole derivatives as 5HT4 -receptor antagonists
US5852014A (en) * 1992-03-12 1998-12-22 Smithkline Beecham P.L.C. Condensed indole derivatives as 5HT4 -receptor antagonists
JPH07507290A (ja) * 1992-05-23 1995-08-10 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー 不安症の治療のための医薬
JPH07508276A (ja) * 1992-06-27 1995-09-14 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー ５−ｈｔ↓４受容体アンタゴニスト含有医薬品
GB9219163D0 (en) * 1992-09-10 1992-10-28 Smithkline Beecham Plc Pharmaceuticals
MX9305947A (es) * 1992-09-29 1994-06-30 Smithkline Beecham Plc Compuestos antagonistas del receptor 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que las contienen.
MX9306311A (es) * 1992-10-13 1994-04-29 Smithkline Beecham Plc Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen
EP0664805A1 (fr) * 1992-10-13 1995-08-02 Smithkline Beecham Plc Esters ou amides heterocycliques utilises comme antagonistes de recepteur de 5-ht 4?
WO1994008965A1 (fr) * 1992-10-16 1994-04-28 Smithkline Beecham Plc Esters/amides n-alkylpiperidinyl-4-methyl carboxyliques des systemes de cycles condenses en tant qu'inhibiteurs de recepteurs 5-ht4
GB9303340D0 (en) * 1993-02-19 1993-04-07 Smithkline Beecham Plc Pharmaceuticals
GB9507882D0 (en) * 1995-04-18 1995-05-31 Pharmacia Spa Substituted dihydrobenzofuran derivatives as 5-ht4 agonists
SK282335B6 (sk) * 1995-11-09 2002-01-07 Sanofi-Synthelabo Deriváty 5-fenyl-3-(piperidin-4-yl)-1,3,4,-oxadiazol-2(3H)-ónu, spôsob ich prípravy a farmaceutický prostriedok, ktorý ich obsahuje
FR2745574B1 (fr) * 1996-03-04 1998-04-03 Synthelabo Derives de 5-phenyl-3-(piperidin-4-yl)-1, 3, 4-oxadiazol-2 (3h)-one, leur preparation et leur application en therapeutique
TW445263B (en) 1996-02-29 2001-07-11 Janssen Pharmaceutica Nv Novel esters of 1,4-disubstituted piperidine derivatives
FR2762316B1 (fr) * 1997-04-18 1999-12-17 Sanofi Synthelabo Derives de 5-aryl-3-(8-azabicyclo[3.2.1] octan-3-yl)-1,3,4- oxadiazol-2(3h)-one, leur preparation et leur application en therapeutique
FR2763068B1 (fr) * 1997-05-06 1999-06-04 Synthelabo Derives de 3-(pyrrolidin-3-yl)-1,3,4-oxadiazol-2(3h)-one, leur preparation et leur application en therapeutique
TW548103B (en) 1997-07-11 2003-08-21 Janssen Pharmaceutica Nv Bicyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives
BRPI9913542B8 (pt) * 1998-09-10 2021-05-25 Hoffmann La Roche derivados de dihidrobenzodioxina carboxamida e dihidrobenzodioxina cetona como antagonistas do receptor 5-ht4 bem como composição farmacêutica, processo para a preparação dos referidos derivados e uso dos mesmos
TW570920B (en) * 1998-12-22 2004-01-11 Janssen Pharmaceutica Nv 4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders
WO2005003122A1 (fr) * 2003-06-19 2005-01-13 Janssen Pharmaceutica N.V. 4-(aminomethyl)-piperidine benzamides antagonistes des recepteurs 5ht4

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59186969A (ja) * 1983-04-08 1984-10-23 Yoshitomi Pharmaceut Ind Ltd ベンゾフラン−およびベンゾピランカルボキサミド誘導体
US5122528A (en) * 1983-12-22 1992-06-16 Erbamont, Inc. Analgesic use of benzobicyclic carboxamides
US4888353A (en) * 1986-02-28 1989-12-19 Erbamont, Inc. Carboxamides useful as antiemetic or antipsychotic agents
CA1297877C (fr) * 1983-12-22 1992-03-24 Daniel Lednicer Benzofurancarboxamides utilises comme agents antiemetiques ou antipsychotiques
SE8503055D0 (sv) * 1985-06-19 1985-06-19 Astra Laekemedel Ab Piperonylcarboxamido derivatives
FR2593504B1 (fr) * 1986-01-30 1988-12-09 Ile De France Nouveaux derives de dihydrobenzofuranne - et de chromane - carboxamides, leurs procedes de preparation et leur utilisation comme neuroleptiques
JPS62234083A (ja) * 1986-02-28 1987-10-14 アーバモント　インク　ディビーエイ　アドリヤ　ラボラトリーズ 鎮吐薬または精神病治療薬として有用なカルボキサミド類
EP0314483A1 (fr) * 1987-10-29 1989-05-03 Erbamont, Inc. Préparation de benzamides
US5374637A (en) * 1989-03-22 1994-12-20 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
US5122361A (en) * 1989-04-17 1992-06-16 Trustees Of The University Of Pennsylvania Dopamine receptor ligands and imaging agents
GB9005014D0 (en) * 1990-03-06 1990-05-02 Janssen Pharmaceutica Nv N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives
JPH04225954A (ja) * 1990-05-02 1992-08-14 Yoshitomi Pharmaceut Ind Ltd アミド化合物、その医薬用途および新規１−置換ピロリジンメチルアミン類
GB9028105D0 (en) * 1990-12-27 1991-02-13 Erba Carlo Spa Process for the preparation of substituted benzofuran derivatives
US5114947A (en) * 1990-12-27 1992-05-19 Erbamont Inc. Method for alleviating anxiety using benzobicyclic carboxamides
JPH05163270A (ja) * 1991-05-13 1993-06-29 Yoshitomi Pharmaceut Ind Ltd ベンゾフランカルボキサミド化合物
JPH04364181A (ja) * 1991-06-04 1992-12-16 Yoshitomi Pharmaceut Ind Ltd ベンゾフランカルボキサミド化合物

Also Published As

Publication number Publication date
MX9300616A (es) 1993-09-01
EP0625149A1 (fr) 1994-11-23
NZ246915A (en) 1996-05-28
KR950700288A (ko) 1995-01-16
AU3457293A (en) 1993-09-03
AU667874B2 (en) 1996-04-18
WO1993016072A1 (fr) 1993-08-19
JPH07503480A (ja) 1995-04-13

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead