CA2126680C - Novel megakaryocyte potentiator - Google Patents

Novel megakaryocyte potentiator Download PDF

Info

Publication number
CA2126680C
CA2126680C CA002126680A CA2126680A CA2126680C CA 2126680 C CA2126680 C CA 2126680C CA 002126680 A CA002126680 A CA 002126680A CA 2126680 A CA2126680 A CA 2126680A CA 2126680 C CA2126680 C CA 2126680C
Authority
CA
Canada
Prior art keywords
meg
megakaryocyte
pot
potentiator
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002126680A
Other languages
English (en)
French (fr)
Other versions
CA2126680A1 (en
Inventor
Nozomi Yamaguchi
Masayoshi Oh-Eda
Kunihiro Hattori
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of CA2126680A1 publication Critical patent/CA2126680A1/en
Application granted granted Critical
Publication of CA2126680C publication Critical patent/CA2126680C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Amplifiers (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA002126680A 1991-12-27 1992-12-24 Novel megakaryocyte potentiator Expired - Lifetime CA2126680C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP361522/1991 1991-12-27
JP36152291 1991-12-27
JP122518/1992 1992-03-31
JP12251892 1992-03-31
PCT/JP1992/001689 WO1993013132A1 (fr) 1991-12-27 1992-12-24 Nouvel amplificateur de megakaryocytes

Publications (2)

Publication Number Publication Date
CA2126680A1 CA2126680A1 (en) 1993-07-08
CA2126680C true CA2126680C (en) 2002-10-08

Family

ID=26459624

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002126680A Expired - Lifetime CA2126680C (en) 1991-12-27 1992-12-24 Novel megakaryocyte potentiator

Country Status (12)

Country Link
US (1) US5498698A (ref)
EP (1) EP0621285B1 (ref)
JP (1) JP3328341B2 (ref)
KR (1) KR100233701B1 (ref)
CN (1) CN1075148A (ref)
AT (1) ATE221084T1 (ref)
AU (1) AU658040B2 (ref)
CA (1) CA2126680C (ref)
DE (1) DE69232698T2 (ref)
ES (1) ES2180542T3 (ref)
TW (1) TW224975B (ref)
WO (1) WO1993013132A1 (ref)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL107366A (en) * 1992-10-23 2003-03-12 Chugai Pharmaceutical Co Ltd Genes coding for megakaryocyte potentiator
DE69503849T2 (de) * 1994-03-31 1999-04-01 Amgen Inc., Thousand Oaks, Calif. Zusammensetzungen und Verfahren zur Anregung des Wachstums und der Differenzierung von Megakaryozyten
US5795569A (en) * 1994-03-31 1998-08-18 Amgen Inc. Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation
US7375183B1 (en) * 1996-01-05 2008-05-20 The United States Of America As Represented By The Department Of Health And Human Services Mesothelin, immunogenic peptides derived therefrom, and compositions comprising mesothelin, or immunogenic peptides thereof
JP2000505787A (ja) * 1996-01-05 2000-05-16 アメリカ合衆国 中皮抗原及びそれを標的化するための方法及びキット
US6809184B1 (en) * 1997-12-01 2004-10-26 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Antibodies, including FV molecules, and immunoconjugates having high binding affinity for mesothelin and methods for their use
US6589759B1 (en) 1999-03-30 2003-07-08 Trustees Of Boston University Compositions and methods for producing platelets and/or proplatelets from megakaryocytes
DE60039510D1 (de) 1999-05-27 2008-08-28 Us Gov Health & Human Serv Immunokonjugate mit hoher bindungsaffinität
US9200036B2 (en) 2002-07-12 2015-12-01 The Johns Hopkins University Mesothelin vaccines and model systems
AU2003259109A1 (en) * 2002-07-12 2004-02-02 The Johns Hopkins University Mesothelin vaccines and model systems
US20090110702A1 (en) * 2002-07-12 2009-04-30 The Johns Hopkins University Mesothelin Vaccines and Model Systems and Control of Tumors
US20040180387A1 (en) * 2003-03-13 2004-09-16 Fujirebio Diagnostics, Inc. Detection of urinary mesothelin-/megakaryocyte potentiating factor-related peptides for assessment of ovarian cancer
SI2195017T1 (sl) 2007-10-01 2015-01-30 Bristol-Myers Squibb Company Človeška protitelesa, ki vežejo mezotelin in njihova uporaba

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU646530B2 (en) * 1990-12-28 1994-02-24 Asahi Kasei Kogyo Kabushiki Kaisha Novel megakaryocyte amplifier and production thereof
JPH04295500A (ja) * 1991-03-26 1992-10-20 Asahi Chem Ind Co Ltd 新規な巨核球増幅因子とその製法

Also Published As

Publication number Publication date
JPH05331200A (ja) 1993-12-14
WO1993013132A1 (fr) 1993-07-08
EP0621285A4 (en) 1995-05-24
EP0621285B1 (en) 2002-07-24
ATE221084T1 (de) 2002-08-15
ES2180542T3 (es) 2003-02-16
KR100233701B1 (ko) 1999-12-01
AU658040B2 (en) 1995-03-30
CA2126680A1 (en) 1993-07-08
DE69232698T2 (de) 2003-03-20
KR940703858A (ko) 1994-12-12
US5498698A (en) 1996-03-12
AU3172193A (en) 1993-07-28
EP0621285A1 (en) 1994-10-26
JP3328341B2 (ja) 2002-09-24
DE69232698D1 (de) 2002-08-29
CN1075148A (zh) 1993-08-11
TW224975B (ref) 1994-06-11

Similar Documents

Publication Publication Date Title
KR100205078B1 (ko) 염기성 섬유 아세포 성장인자 및 이의 생산방법
DK166832B1 (da) Rekombinante gamma-interferon-polypeptider, dna, som koder for dem, replicerbare udtrykkelsesvektorer, som kan udtrykke dem, transformante celler, som er transformeret med udtrykkelsesvektorerne, og farmaceutiske praeparater indeholdende polypeptider
US5407914A (en) Pulmonary surfactant protein and related polypeptides
US5723318A (en) DNA coding for megakaryocyte potentiator
CA1331356C (en) Mutant human angiogenin (angiogenesis factor with superior angiogenin activity) genes therefor and methods of expression
EP0621285B1 (en) Novel megakaryocyte potentiator
CN117843763B (zh) 生物合成人体结构性材料xvii型胶原蛋白的方法
CN118909092B (zh) 人体结构性材料xx型胶原蛋白及其生物合成方法
JPH05508775A (ja) プロテアーゼ耐性ｐｄｇｆ及び使用法
EP0550769B1 (en) Use of hepatocyte growth factors for the manufacture of a hemopoietic stem cell augmenting agent
CA2328463A1 (en) Matrix binding factor
Bourdrel et al. Recombinant human transforming growth factor-β1: expression by Chinese hamster ovary cells, isolation, and characterization
WO1996016987A1 (en) Thrombocytotic factor
HUT69928A (en) Modified platelet factor-4
US5656458A (en) Expression and processing of amino terminus acetylated FGF's in yeast
JP3106191B1 (ja) Ｆｇｆ−５の生理的機能制御ペプチド及び該ペプチドを含有する医薬組成物
ES2288016T3 (es) Estañocalcina humana y usos de la misma para inhibir la adipogenesis.
CN108017711B (zh) 一种抗钙化短肽及其应用
US5807711A (en) Parenchymal hepatocyte growth factors
JPH05504134A (ja) オンコスタチンｍ活性を有する新規なタンパク質及びそれらの調製方法
AU744514B2 (en) Matrix binding factor
CA1341070C (en) Pulmonary surfactant protein and related polypeptide
AU726538B2 (en) Pharmaceutical composition for increasing differentiation of osteoblasts
HK40130855A (zh) 具有三螺旋结构的多肽、重组xii型人源化胶原蛋白及其应用
JPS62169799A (ja) マクロフア−ジ分化増殖促進物質

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20121224