CA2125077A1 - Imidazopyridine - Google Patents

Imidazopyridine

Info

Publication number
CA2125077A1
CA2125077A1 CA002125077A CA2125077A CA2125077A1 CA 2125077 A1 CA2125077 A1 CA 2125077A1 CA 002125077 A CA002125077 A CA 002125077A CA 2125077 A CA2125077 A CA 2125077A CA 2125077 A1 CA2125077 A1 CA 2125077A1
Authority
CA
Canada
Prior art keywords
formula
oxo
compound
dihydro
het2
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002125077A
Other languages
English (en)
French (fr)
Inventor
Mathias Osswald
Werner Mederski
Dieter Dorsch
Pierre Schelling
Norbert Beier
Ingeborg Lues
Klaus-Otto Minck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of CA2125077A1 publication Critical patent/CA2125077A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA002125077A 1993-06-07 1994-06-03 Imidazopyridine Abandoned CA2125077A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4318813A DE4318813A1 (de) 1993-06-07 1993-06-07 Imidazopyridine
DEP4318813.3 1993-06-07

Publications (1)

Publication Number Publication Date
CA2125077A1 true CA2125077A1 (en) 1994-12-08

Family

ID=6489765

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002125077A Abandoned CA2125077A1 (en) 1993-06-07 1994-06-03 Imidazopyridine

Country Status (16)

Country Link
US (1) US5438063A (en:Method)
EP (1) EP0628556A1 (en:Method)
JP (1) JPH072854A (en:Method)
KR (1) KR950000697A (en:Method)
CN (1) CN1100721A (en:Method)
AU (1) AU689468B2 (en:Method)
CA (1) CA2125077A1 (en:Method)
CZ (1) CZ137694A3 (en:Method)
DE (1) DE4318813A1 (en:Method)
HU (1) HUT71483A (en:Method)
NO (1) NO942095L (en:Method)
PL (1) PL303715A1 (en:Method)
RU (1) RU94019981A (en:Method)
SK (1) SK67794A3 (en:Method)
TW (1) TW269689B (en:Method)
ZA (1) ZA943996B (en:Method)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2708612B1 (fr) * 1993-08-05 1996-03-01 Roussel Uclaf Nouveaux dérivés bicycliques de l'imidazole, leur procédé de préparation, les nouveaux intermédiaires obtenus, leur application à titre de médicaments et les compositions pharmaceutiques les renfermant.
DE4432860A1 (de) * 1994-09-15 1996-03-21 Merck Patent Gmbh Imidazopyridine
AU714618B2 (en) * 1996-07-15 2000-01-06 Sankyo Company Limited Medicinal composition
DE19845153A1 (de) * 1998-10-01 2000-04-06 Merck Patent Gmbh Imidazo[4,5]-pyridin-4-on-derivate
GB0215293D0 (en) 2002-07-03 2002-08-14 Rega Foundation Viral inhibitors
AU2003284001A1 (en) 2002-10-07 2004-05-04 Bristol-Myers Squibb Company Triazolone and triazolethione derivatives
ATE544765T1 (de) 2003-12-22 2012-02-15 Leuven K U Res & Dev Imidazoä4,5-cüpyridinverbindungen und verfahren zur antiviralen behandlung
NZ556624A (en) 2004-12-21 2010-06-25 Gilead Sciences Inc 5-((3-(2,4-trifluoromethyphenyl)isoxazol-5-yl)methyl)-2-(2-fluorophenyl)-5H-imidazo[4,5-c]pyridine and method of antiviral treatment
NZ562887A (en) * 2005-03-30 2010-10-29 Takeda Pharmaceutical Benzimidazole derivative and use as angiotensin II antagonist
SG175604A1 (en) 2006-07-07 2011-11-28 Gilead Sciences Inc Novel pyridazine compound and use thereof
UA99466C2 (en) 2007-07-06 2012-08-27 Гилиад Сайенсиз, Инк. Crystalline pyridazine compound
EP2321011A1 (en) * 2008-06-25 2011-05-18 Pfizer Inc. Diaryl compounds and uses thereof
WO2009158309A2 (en) * 2008-06-25 2009-12-30 Ligand Pharmaceuticals Inc. Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
WO2010004948A1 (ja) 2008-07-08 2010-01-14 株式会社カネカ α－ヘテロ置換アルキルハロヒドロシランの製造方法およびその利用
CZ306650B6 (cs) * 2011-03-04 2017-04-19 Zentiva, K.S. Způsob výroby 2-ethoxy-1-((2´-((hydroxyamino)iminomethyl)bifenyl-4-yl)methyl)-1H-benzo[d]imidazol-7-karboxylové kyseliny a jejích esterů, klíčových intermediátů syntézy azilsartanu
WO2015095108A1 (en) * 2013-12-18 2015-06-25 Merck Sharp & Dohme Corp. Thioether-piperidinyl orexin receptor antagonists
CN105669495A (zh) * 2014-11-21 2016-06-15 重庆朗天制药有限公司 一种阿奇沙坦及其中间体新的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4880804A (en) * 1988-01-07 1989-11-14 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking benzimidazoles
US5223499A (en) * 1989-05-30 1993-06-29 Merck & Co., Inc. 6-amino substituted imidazo[4,5-bipyridines as angiotensin II antagonists
US5332744A (en) * 1989-05-30 1994-07-26 Merck & Co., Inc. Substituted imidazo-fused 6-membered heterocycles as angiotensin II antagonists
IL94390A (en) * 1989-05-30 1996-03-31 Merck & Co Inc The 6-membered trans-nitrogen-containing heterocycles are compressed with imidazo and pharmaceutical preparations containing them
EP0430709A3 (en) * 1989-12-01 1992-02-12 Glaxo Group Limited Benzthiophen derivatives
DE4110019C2 (de) * 1991-03-27 2000-04-13 Merck Patent Gmbh Imidazopyridine, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
IL102183A (en) * 1991-06-27 1999-11-30 Takeda Chemical Industries Ltd Biphenyl substituted heterocyclic compounds their production and pharmaceutical compositions comprising them
DE4141788A1 (de) * 1991-12-18 1993-06-24 Merck Patent Gmbh Imidazopyridine
DE4305602A1 (de) * 1992-06-17 1993-12-23 Merck Patent Gmbh Imidazopyridine

Also Published As

Publication number Publication date
HU9401692D0 (en) 1994-09-28
US5438063A (en) 1995-08-01
ZA943996B (en) 1995-02-06
JPH072854A (ja) 1995-01-06
EP0628556A1 (de) 1994-12-14
PL303715A1 (en) 1995-01-09
KR950000697A (ko) 1995-01-03
HUT71483A (en) 1995-11-28
NO942095L (no) 1994-12-08
RU94019981A (ru) 1996-06-10
CZ137694A3 (en) 1994-12-15
AU6348794A (en) 1994-12-08
CN1100721A (zh) 1995-03-29
AU689468B2 (en) 1998-04-02
SK67794A3 (en) 1995-02-08
NO942095D0 (no) 1994-06-06
TW269689B (en:Method) 1996-02-01
DE4318813A1 (de) 1994-12-08

Similar Documents

Publication Publication Date Title
AU2020207591B2 (en) Substituted pyrrolidine amides III
AU2011258436B2 (en) Soluble guanylate cyclase activators
KR100373972B1 (ko) 이미다조피리딘유도체
AU669895B2 (en) Imidazopyridines
CN105814050B (zh) 用作tnf活性调节剂的吡唑并吡啶衍生物
AU2014217453B2 (en) Heterocyclic amides as kinase inhibitors
JP4764823B2 (ja) キナーゼ阻害剤としての１，６−二置換アザベンゾイミダゾールの調製
MX2014001851A (es) Inhibidores del canal de heteroarilo sodio.
IE83789B1 (en) Heterocyclic compounds, their production and use as angiotensin II antagonists
US5438063A (en) Imidazopyridines as angiotensin II antagonists
OA13347A (en) Triazole derivatives as vasopressin antagonists.
WO2004047760A2 (en) Novel chemical compounds
CA2608718A1 (en) 1, 2, 4-triazole derivatives as vasopressin antagonists
AU2013353117A1 (en) Imidazopyridine compound
CN105814041A (zh) 用作tnf活性调节剂的苯并三唑衍生物
EP3079701A1 (en) Soluble guanylate cyclase activators
CN105814043A (zh) 用作tnf活性调节剂的三唑并吡啶衍生物
JP2002526542A (ja) Ｘａ因子阻害作用を有するイミダゾール［４，５−Ｃ−］−ピリジン−４−オン誘導体
AU2006206653A1 (en) Aminomethyl beta-secretase inhibitors for the treatment of Alzheimer's disease
AU2007267170A1 (en) 2-phenyl-5-amino-1,3,4-oxadiazoles and their use as nicotinic acetylcholine receptor ligands
CA2664130A1 (en) Piperidine and pyrrolidine beta-secretase inhibitors for the treatment of alzheimer's disease
CN104395324B (zh) 咪唑并‑噁二唑和咪唑并‑噻二唑衍生物
EP4367103B1 (en) Inhibitors of alpha-hemolysin of staphylococcus aureus
WO2007019078A2 (en) Tricyclic beta-secretase inhibitors for the treatment of alzheimer's disease
CN101312970A (zh) 6-杂芳基吡啶并吲哚酮衍生物，它们的制备及其治疗应用

Legal Events

Date Code Title Description
FZDE Discontinued