CA2097211A1 - Methods of using ion trap mass spectrometers - Google Patents
Methods of using ion trap mass spectrometersInfo
- Publication number
- CA2097211A1 CA2097211A1 CA 2097211 CA2097211A CA2097211A1 CA 2097211 A1 CA2097211 A1 CA 2097211A1 CA 2097211 CA2097211 CA 2097211 CA 2097211 A CA2097211 A CA 2097211A CA 2097211 A1 CA2097211 A1 CA 2097211A1
- Authority
- CA
- Canada
- Prior art keywords
- trap
- ion trap
- ion
- supplemental
- ions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000005040 ion trap Methods 0.000 title claims abstract description 74
- 238000000034 method Methods 0.000 title claims abstract description 63
- 150000002500 ions Chemical class 0.000 claims abstract description 158
- 230000000153 supplemental effect Effects 0.000 claims abstract description 37
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 31
- 238000000451 chemical ionisation Methods 0.000 claims abstract 9
- 238000006243 chemical reaction Methods 0.000 claims description 6
- 238000001819 mass spectrum Methods 0.000 claims 3
- 238000010894 electron beam technology Methods 0.000 claims 2
- 238000001360 collision-induced dissociation Methods 0.000 claims 1
- 230000005404 monopole Effects 0.000 claims 1
- 238000002474 experimental method Methods 0.000 abstract description 8
- 230000002730 additional effect Effects 0.000 abstract 1
- 238000010494 dissociation reaction Methods 0.000 abstract 1
- 230000005593 dissociations Effects 0.000 abstract 1
- 101150085091 lat-2 gene Proteins 0.000 description 13
- 241000282320 Panthera leo Species 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 238000009924 canning Methods 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 101150008122 Bcan gene Proteins 0.000 description 2
- 101100536354 Drosophila melanogaster tant gene Proteins 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000005284 excitation Effects 0.000 description 2
- 230000003340 mental effect Effects 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 238000004885 tandem mass spectrometry Methods 0.000 description 2
- NVKAWKQGWWIWPM-ABEVXSGRSA-N 17-β-hydroxy-5-α-Androstan-3-one Chemical compound C1C(=O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC[C@H]21 NVKAWKQGWWIWPM-ABEVXSGRSA-N 0.000 description 1
- 101150091111 ACAN gene Proteins 0.000 description 1
- 244000118350 Andrographis paniculata Species 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N Arginine Chemical compound OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 description 1
- 101100371682 Caenorhabditis elegans cyk-3 gene Proteins 0.000 description 1
- 101100074846 Caenorhabditis elegans lin-2 gene Proteins 0.000 description 1
- 241000282465 Canis Species 0.000 description 1
- 241001212789 Dynamis Species 0.000 description 1
- 101150087426 Gnal gene Proteins 0.000 description 1
- 241000976924 Inca Species 0.000 description 1
- 241000575946 Ione Species 0.000 description 1
- LTXREWYXXSTFRX-QGZVFWFLSA-N Linagliptin Chemical compound N=1C=2N(C)C(=O)N(CC=3N=C4C=CC=CC4=C(C)N=3)C(=O)C=2N(CC#CC)C=1N1CCC[C@@H](N)C1 LTXREWYXXSTFRX-QGZVFWFLSA-N 0.000 description 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 1
- 101100270435 Mus musculus Arhgef12 gene Proteins 0.000 description 1
- 101100497386 Mus musculus Cask gene Proteins 0.000 description 1
- KWYHDKDOAIKMQN-UHFFFAOYSA-N N,N,N',N'-tetramethylethylenediamine Chemical compound CN(C)CCN(C)C KWYHDKDOAIKMQN-UHFFFAOYSA-N 0.000 description 1
- 241000669618 Nothes Species 0.000 description 1
- 241001163743 Perlodes Species 0.000 description 1
- 101100313003 Rattus norvegicus Tanc1 gene Proteins 0.000 description 1
- NFQIAEMCQGTTIR-UHFFFAOYSA-N Repirinast Chemical compound C12=CC=C(C)C(C)=C2NC(=O)C2=C1OC(C(=O)OCCC(C)C)=CC2=O NFQIAEMCQGTTIR-UHFFFAOYSA-N 0.000 description 1
- 241000364027 Sinoe Species 0.000 description 1
- 241000135164 Timea Species 0.000 description 1
- 240000004543 Vicia ervilia Species 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- LOWWYYZBZNSPDT-ZBEGNZNMSA-N delgocitinib Chemical compound C[C@H]1CN(C(=O)CC#N)[C@@]11CN(C=2C=3C=CNC=3N=CN=2)CC1 LOWWYYZBZNSPDT-ZBEGNZNMSA-N 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- JXSJBGJIGXNWCI-UHFFFAOYSA-N diethyl 2-[(dimethoxyphosphorothioyl)thio]succinate Chemical compound CCOC(=O)CC(SP(=S)(OC)OC)C(=O)OCC JXSJBGJIGXNWCI-UHFFFAOYSA-N 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000010445 mica Substances 0.000 description 1
- 229910052618 mica group Inorganic materials 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-M oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC([O-])=O ZQPPMHVWECSIRJ-KTKRTIGZSA-M 0.000 description 1
- 229940061319 ovide Drugs 0.000 description 1
- RVZRBWKZFJCCIB-UHFFFAOYSA-N perfluorotributylamine Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)N(C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F RVZRBWKZFJCCIB-UHFFFAOYSA-N 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 229950009147 repirinast Drugs 0.000 description 1
- 101150081985 scrib gene Proteins 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- HJHVQCXHVMGZNC-JCJNLNMISA-M sodium;(2z)-2-[(3r,4s,5s,8s,9s,10s,11r,13r,14s,16s)-16-acetyloxy-3,11-dihydroxy-4,8,10,14-tetramethyl-2,3,4,5,6,7,9,11,12,13,15,16-dodecahydro-1h-cyclopenta[a]phenanthren-17-ylidene]-6-methylhept-5-enoate Chemical compound [Na+].O[C@@H]([C@@H]12)C[C@H]3\C(=C(/CCC=C(C)C)C([O-])=O)[C@@H](OC(C)=O)C[C@]3(C)[C@@]2(C)CC[C@@H]2[C@]1(C)CC[C@@H](O)[C@H]2C HJHVQCXHVMGZNC-JCJNLNMISA-M 0.000 description 1
- -1 thR ion Chemical class 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/10—Ion sources; Ion guns
- H01J49/14—Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers
- H01J49/145—Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers using chemical ionisation
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
- H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
- H01J49/005—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction by collision with gas, e.g. by introducing gas or by accelerating ions with an electric field
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
- H01J49/4205—Device types
- H01J49/424—Three-dimensional ion traps, i.e. comprising end-cap and ring electrodes
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
- H01J49/426—Methods for controlling ions
- H01J49/427—Ejection and selection methods
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Plasma & Fusion (AREA)
- Electron Tubes For Measurement (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US890,991 | 1986-07-25 | ||
| US89099192A | 1992-05-29 | 1992-05-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2097211A1 true CA2097211A1 (en) | 1993-11-30 |
Family
ID=25397431
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2097211 Abandoned CA2097211A1 (en) | 1992-05-29 | 1993-05-28 | Methods of using ion trap mass spectrometers |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP0575777B1 (enrdf_load_stackoverflow) |
| JP (2) | JP3444429B2 (enrdf_load_stackoverflow) |
| CA (1) | CA2097211A1 (enrdf_load_stackoverflow) |
| DE (3) | DE69328979T2 (enrdf_load_stackoverflow) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5448061A (en) * | 1992-05-29 | 1995-09-05 | Varian Associates, Inc. | Method of space charge control for improved ion isolation in an ion trap mass spectrometer by dynamically adaptive sampling |
| US5291017A (en) * | 1993-01-27 | 1994-03-01 | Varian Associates, Inc. | Ion trap mass spectrometer method and apparatus for improved sensitivity |
| US5396064A (en) * | 1994-01-11 | 1995-03-07 | Varian Associates, Inc. | Quadrupole trap ion isolation method |
| DE4425384C1 (de) * | 1994-07-19 | 1995-11-02 | Bruker Franzen Analytik Gmbh | Verfahren zur stoßinduzierten Fragmentierung von Ionen in Ionenfallen |
| US5714755A (en) * | 1996-03-01 | 1998-02-03 | Varian Associates, Inc. | Mass scanning method using an ion trap mass spectrometer |
| DE19932839B4 (de) * | 1999-07-14 | 2007-10-11 | Bruker Daltonik Gmbh | Fragmentierung in Quadrupol-Ionenfallenmassenspektrometern |
| JP4384542B2 (ja) | 2004-05-24 | 2009-12-16 | 株式会社日立ハイテクノロジーズ | 質量分析装置 |
| DE102005061425B4 (de) * | 2005-12-22 | 2009-06-10 | Bruker Daltonik Gmbh | Rückgesteuerte Fragmentierung in Ionenfallen-Massenspektrometern |
| JP4996962B2 (ja) | 2007-04-04 | 2012-08-08 | 株式会社日立ハイテクノロジーズ | 質量分析装置 |
| GB201208733D0 (en) * | 2012-05-18 | 2012-07-04 | Micromass Ltd | Excitation of reagent molecules within a rf confined ion guide or ion trap to perform ion molecule, ion radical or ion-ion interaction experiments |
| DE102013213501A1 (de) * | 2013-07-10 | 2015-01-15 | Carl Zeiss Microscopy Gmbh | Massenspektrometer, dessen Verwendung, sowie Verfahren zur massenspektrometrischen Untersuchung eines Gasgemisches |
| US10985002B2 (en) * | 2019-06-11 | 2021-04-20 | Perkinelmer Health Sciences, Inc. | Ionization sources and methods and systems using them |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0202943B2 (en) * | 1985-05-24 | 2004-11-24 | Thermo Finnigan LLC | Method of operating an ion trap |
| US4686367A (en) * | 1985-09-06 | 1987-08-11 | Finnigan Corporation | Method of operating quadrupole ion trap chemical ionization mass spectrometry |
| EP0336990B1 (en) * | 1988-04-13 | 1994-01-05 | Bruker Franzen Analytik GmbH | Method of mass analyzing a sample by use of a quistor and a quistor designed for performing this method |
| EP0362432A1 (en) * | 1988-10-07 | 1990-04-11 | Bruker Franzen Analytik GmbH | Improvement of a method of mass analyzing a sample |
| US5200613A (en) * | 1991-02-28 | 1993-04-06 | Teledyne Mec | Mass spectrometry method using supplemental AC voltage signals |
-
1993
- 1993-05-28 EP EP19930108670 patent/EP0575777B1/en not_active Expired - Lifetime
- 1993-05-28 DE DE1993628979 patent/DE69328979T2/de not_active Expired - Fee Related
- 1993-05-28 DE DE1993621165 patent/DE69321165T2/de not_active Expired - Fee Related
- 1993-05-28 DE DE1993633589 patent/DE69333589T2/de not_active Expired - Fee Related
- 1993-05-28 CA CA 2097211 patent/CA2097211A1/en not_active Abandoned
- 1993-05-31 JP JP15304193A patent/JP3444429B2/ja not_active Expired - Fee Related
-
2003
- 2003-05-22 JP JP2003145488A patent/JP2004004082A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE69333589T2 (de) | 2005-02-03 |
| JPH0696727A (ja) | 1994-04-08 |
| DE69333589D1 (de) | 2004-09-16 |
| DE69328979T2 (de) | 2001-02-15 |
| EP0575777A2 (en) | 1993-12-29 |
| DE69321165T2 (de) | 1999-06-02 |
| JP3444429B2 (ja) | 2003-09-08 |
| EP0575777B1 (en) | 1998-09-23 |
| JP2004004082A (ja) | 2004-01-08 |
| DE69321165D1 (de) | 1998-10-29 |
| EP0575777A3 (enrdf_load_stackoverflow) | 1994-03-16 |
| DE69328979D1 (de) | 2000-08-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Dead |