CA2073741C - Thromboplastin extract, reagent, and preparation thereof - Google Patents

Thromboplastin extract, reagent, and preparation thereof

Info

Publication number
CA2073741C
CA2073741C CA002073741A CA2073741A CA2073741C CA 2073741 C CA2073741 C CA 2073741C CA 002073741 A CA002073741 A CA 002073741A CA 2073741 A CA2073741 A CA 2073741A CA 2073741 C CA2073741 C CA 2073741C
Authority
CA
Canada
Prior art keywords
thromboplastin
extract
preparing
powdered
reagent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002073741A
Other languages
English (en)
French (fr)
Other versions
CA2073741A1 (en
Inventor
David A. Barrow
Richard L. Rullman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Helena Laboratories Corp
Original Assignee
Helena Laboratories Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Helena Laboratories Corp filed Critical Helena Laboratories Corp
Publication of CA2073741A1 publication Critical patent/CA2073741A1/en
Application granted granted Critical
Publication of CA2073741C publication Critical patent/CA2073741C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/839—Nerves; brain
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/85—Reproductive organs or embryos
    • Y10S530/851—Placenta; amniotic fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002073741A 1991-07-22 1992-07-13 Thromboplastin extract, reagent, and preparation thereof Expired - Fee Related CA2073741C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/733,325 1991-07-22
US07/733,325 US5254350A (en) 1991-07-22 1991-07-22 Method of preparing a thromboplastin extract

Publications (2)

Publication Number Publication Date
CA2073741A1 CA2073741A1 (en) 1993-01-23
CA2073741C true CA2073741C (en) 1999-09-21

Family

ID=24947142

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002073741A Expired - Fee Related CA2073741C (en) 1991-07-22 1992-07-13 Thromboplastin extract, reagent, and preparation thereof

Country Status (4)

Country Link
US (3) US5254350A (cg-RX-API-DMAC7.html)
EP (1) EP0524803A2 (cg-RX-API-DMAC7.html)
JP (1) JP2828837B2 (cg-RX-API-DMAC7.html)
CA (1) CA2073741C (cg-RX-API-DMAC7.html)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2080428C (en) * 1991-10-22 2004-01-27 Ray F. Ebert A method for preparing a thromboplastin reagent from cultured cells that is suitable for use in the prothrombin time test
US5418141A (en) * 1994-05-06 1995-05-23 Avocet Medical, Inc. Test articles for performing dry reagent prothrombin time assays
JPH08224227A (ja) * 1995-02-22 1996-09-03 Internatl Reagents Corp 血液採血管
US5688208A (en) * 1995-11-03 1997-11-18 Plemmons; David Limb exercise/therapy apparatus
WO2000062828A1 (en) * 1996-04-30 2000-10-26 Medtronic, Inc. Autologous fibrin sealant and method for making the same
JP2000509307A (ja) * 1996-04-30 2000-07-25 メドトロニック，インコーポレイテッド 自己由来フィブリン密封材の製造方法
US6379975B1 (en) 1996-11-27 2002-04-30 T.A.C. Thrombosis And Coagulation Aktiebolag Methods and reagents for determining protein S
ES2255157T3 (es) * 1997-04-23 2006-06-16 Instrumentation Laboratory S.P.A. Reactivo de tiempo de protrombina basado en el factor tisular recombinante de conejo.
DE19720853A1 (de) * 1997-05-17 1998-11-19 Dade Behring Marburg Gmbh Erhöhung der FVII Empfindlichkeit eines Thromboplastinreagenzes
CA2295247C (en) 1997-06-18 2009-05-26 Cohesion Technologies, Inc. Compositions containing thrombin and microfibrillar collagen
ATE313068T1 (de) 1998-10-07 2005-12-15 Trinity Biotech Mfg Ltd Thromboplastin-reagenzien und verfahren zur herstellung und anwendung derselben
DE19858278A1 (de) * 1998-12-17 2000-06-21 Dade Behring Marburg Gmbh Verfahren zum Lokalisieren von Defekten im Gerinnungssystem
CN100553678C (zh) 1999-02-22 2009-10-28 巴克斯特国际有限公司 新的无白蛋白的因子ⅷ制剂
DE60011274T2 (de) 1999-09-03 2005-07-07 Roche Diagnostics Corp., Indianapolis Verfahren, reagenz und messkartusche zur bestimmung der gerinnungszeit
RU2160111C1 (ru) * 1999-10-07 2000-12-10 Кировский НИИ гематологии и переливания крови Способ получения высокоактивного сырья для изготовления тромбопластина полного растворимого
ATE293159T1 (de) * 1999-12-14 2005-04-15 Thermo Biostar Inc Stabilisierendes verdünnungsmittel für polypeptide und antigene
RU2161975C1 (ru) * 2000-01-05 2001-01-20 Кировский НИИ гематологии и переливания крови Способ сохранения активности сырья для изготовления тромбопластина полного растворимого до и во время лиофилизации
US6448024B1 (en) 2000-10-03 2002-09-10 Roche Diagnostics Corporation Method, reagent, cartridge, and device for determining fibrinogen
US6855509B2 (en) 2000-12-19 2005-02-15 Instrumentation Laboratory Company Protein S functional assay and kit therefor
US6942880B1 (en) * 2001-04-09 2005-09-13 Medtronic, Inc. Autologous platelet gel having beneficial geometric shapes and methods of making the same
RU2245154C1 (ru) * 2003-06-16 2005-01-27 ГУ Кировский НИИ гематологии и переливания крови Способ повышения качества сохранения активности сырья для изготовления реактива тромбопластина полного растворимого до и во время сублимации
DE10360628A1 (de) * 2003-12-19 2005-07-21 Dade Behring Marburg Gmbh Kontrollplasma für Thrombinaktivitätstests
US7148067B2 (en) * 2004-08-31 2006-12-12 The Board Of Trustees Of The University Of Illinois Thromboplastin reagents
EP1853926A2 (en) * 2005-02-16 2007-11-14 The Board Of Trustees Of The University Of Illinois Procoagulants based on metal-chelating lipids
CN101184775A (zh) * 2005-03-04 2008-05-21 伊利诺斯大学理事会 凝血及纤溶级联系统的调控剂
WO2006104398A1 (en) * 2005-03-26 2006-10-05 Protemix Corporation Limited Copper antagonist compositions
US9096839B2 (en) * 2006-04-26 2015-08-04 Arteriocyte Medical Systems, Inc. Compositions and methods of preparation thereof
RU2329819C2 (ru) * 2006-07-25 2008-07-27 ООО "НПФ ВятМедДиа" Способ получения диагностического реагента тромбопластина полного из плаценты человека
US8821861B2 (en) * 2007-10-05 2014-09-02 The Board Of Trustees Of The University Of Illinois Fibrin sealant
WO2009061697A1 (en) 2007-11-09 2009-05-14 The Board Of Trustees Of The University Of Illinois Anticoagulant antagonist and hemophilia procoagulant
CA2742328C (en) 2008-11-07 2019-02-26 Baxter International Inc. Factor viii formulations
EP2405274A1 (en) 2010-07-06 2012-01-11 Good biomarker Sciences B.V. Monitoring anticoagulant therapy and identifying reversible direct factor Xa inhibitors
CN102180958B (zh) * 2011-03-23 2013-05-15 宁波大学 一种工业化生产兔脑粉的加工方法
JP6250306B2 (ja) * 2013-05-28 2017-12-20 株式会社Ｌｓｉメディエンス リポ化トロンボプラスチン含有血液凝固能測定試薬及び測定方法
EP3489692A1 (de) 2017-11-28 2019-05-29 Siemens Healthcare Diagnostics Products GmbH Prothrombinzeit-reagenz enthaltend einen eisenchelator
CN116165039B (zh) * 2023-02-11 2023-09-22 保定天岳生物工程有限公司 一种代替传统兔脑粉的兔脑组织制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3522148A (en) * 1965-08-13 1970-07-28 Dade Reagents Inc Stabilized thromboplastin preparation
DE3150596A1 (de) * 1981-12-21 1983-06-30 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur herstellung von gewebsthromboplastin
DE3413311A1 (de) * 1984-04-09 1985-10-17 Behringwerke Ag, 3550 Marburg Reagenz zur bestimmung der thromboplastinzeit
EP0396733B1 (en) * 1988-11-23 1994-01-05 Baxter Diagnostics Inc. Improved extraction methods for preparing thromboplastin reagents

Also Published As

Publication number Publication date
US5254350A (en) 1993-10-19
JP2828837B2 (ja) 1998-11-25
EP0524803A2 (en) 1993-01-27
JPH05207897A (ja) 1993-08-20
CA2073741A1 (en) 1993-01-23
US5391380A (en) 1995-02-21
US5512304A (en) 1996-04-30
EP0524803A3 (cg-RX-API-DMAC7.html) 1994-03-23

Similar Documents

Publication Publication Date Title
CA2073741C (en) Thromboplastin extract, reagent, and preparation thereof
US5721140A (en) Stable coagulation controls
US5091304A (en) Whole blood activated partial thromboplastin time test and associated apparatus
Marciniak et al. Autoprothrombin C: A second enzyme from prothrombin
JP2002519703A (ja) Ｐｔ、及び、ａｐｔｔ分析のための血液凝固コントロール
US6733985B1 (en) Preparation of stable liquid and dried synthetic prothrombin time reagents
US5426031A (en) Extraction methods for preparing thromboplastin reagents
CN110887970B (zh) 抽提缓冲液、兔脑抽提液、pt检测试剂及pt检测试剂盒
US4946775A (en) Composition, kit and method for assaying heparin and a method for making the composition
US5504193A (en) Extraction methods for preparing thromboplastin reagents
JP2002526557A (ja) トロンボプラスチン試薬ならびにそのような試薬の製造および使用方法
US5939325A (en) Stable whole blood coagulation controls
EP0972203B1 (de) REAGENS ZUR BESTIMMUNG DER aPTT
US6183979B1 (en) Preparation of dried synthetic prothrombin time reagents
US4851336A (en) Composition, kit, and method for assaying heparinano a method for making the composition
EP0986394A1 (en) Anti-coagulation of blood, blood plasma or synovial fluid products
JP4532731B2 (ja) 長期に安定で即時使用可能なリストセチン補因子試験試薬
Atkinson et al. The use of Dispholidus typus venom in elucidating the cause of a low prothrombin index
Hjort et al. Effects of thorium dioxide upon blood clotting and platelets. I. In vitro studies
Nour-Eldin et al. Antithrombin in brain tissue
Baker et al. Some properties of platelet cofactor I concentrates of bovine origin
Milstone et al. Lipoid Thromboplastin and Trypsin
Pechet et al. The Effect of Trypsin and Storage on Aggregation and Release of Human Gel-Filtered Platelets
Ziegler et al. Reappraisal of thromboplastin

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed
MKLA Lapsed

Effective date: 20010713