CA2047702C - Serpin resistant chymotrypsin superfamily proteases particularly pai-1 resistant t-pa, complementary inhibitor mutants; compositions; genes; expression - Google Patents
Serpin resistant chymotrypsin superfamily proteases particularly pai-1 resistant t-pa, complementary inhibitor mutants; compositions; genes; expression Download PDFInfo
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- CA2047702C CA2047702C CA002047702A CA2047702A CA2047702C CA 2047702 C CA2047702 C CA 2047702C CA 002047702 A CA002047702 A CA 002047702A CA 2047702 A CA2047702 A CA 2047702A CA 2047702 C CA2047702 C CA 2047702C
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- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/108—Plasmid DNA episomal vectors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/55—Vector systems having a special element relevant for transcription from bacteria
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
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- Biophysics (AREA)
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- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
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- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
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- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31921289A | 1989-03-06 | 1989-03-06 | |
| US319,212 | 1989-11-13 | ||
| US07/434,748 US5550042A (en) | 1989-03-06 | 1989-11-13 | Serine protease mutants of the chymotrypsin superfamily resistant to inhibition by their cognate inhibitors and genes encoding the same and serine protease inhibitor mutants and genes encoding the same |
| US434,748 | 1989-11-13 | ||
| PCT/US1990/000947 WO1990010649A1 (en) | 1989-03-06 | 1990-03-01 | Serpin resistant chymotrypsin superfamily proteases, particularly pai-1 resistant +-pa, complementary inhibitor mutants; compositions; genes; expression |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2047702A1 CA2047702A1 (en) | 1990-09-07 |
| CA2047702C true CA2047702C (en) | 2000-10-24 |
Family
ID=23241316
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002047702A Expired - Lifetime CA2047702C (en) | 1989-03-06 | 1990-03-01 | Serpin resistant chymotrypsin superfamily proteases particularly pai-1 resistant t-pa, complementary inhibitor mutants; compositions; genes; expression |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5728564A (en22) |
| EP (2) | EP1029921B1 (en22) |
| JP (3) | JP2991769B2 (en22) |
| AT (2) | ATE199090T1 (en22) |
| AU (1) | AU637791B2 (en22) |
| CA (1) | CA2047702C (en22) |
| DE (2) | DE69033699T2 (en22) |
| DK (2) | DK1029921T3 (en22) |
| ES (2) | ES2154629T3 (en22) |
| WO (1) | WO1990010649A1 (en22) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5262170A (en) * | 1988-09-02 | 1993-11-16 | Genentech, Inc. | Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells |
| US5714145A (en) * | 1988-09-02 | 1998-02-03 | Genentech, Inc. | Tissue plasminogen activator having zymogenic or fibrin specific properties |
| US5866413A (en) * | 1989-03-06 | 1999-02-02 | Board Of Regents Of The University Of Texas System | Pai-1 mutants |
| US5358932A (en) * | 1989-12-29 | 1994-10-25 | Zymogenetics, Inc. | Hybrid protein C |
| AU7168591A (en) * | 1989-12-29 | 1991-07-24 | Zymogenetics Inc. | Hybrid protein c |
| GB9011861D0 (en) * | 1990-05-26 | 1990-07-18 | Beecham Group Plc | Novel compounds |
| ES2067326T3 (es) * | 1990-12-18 | 1995-03-16 | Genentech Inc | Variante especifica de activador de plasminogeno tisular. |
| EP0786257B1 (en) * | 1992-06-03 | 2003-07-30 | Genentech, Inc. | Tissue plasminogen activator glycosylation variants with improved therapeutic properties |
| GB9216558D0 (en) * | 1992-08-04 | 1992-09-16 | British Bio Technology | Modified proteases |
| US5567602A (en) * | 1992-08-12 | 1996-10-22 | Arris Pharmaceutical Corporation | Recombinant production of chymase |
| ES2080657B1 (es) * | 1993-09-27 | 1996-11-01 | Britisch Bio Technology Limite | Proteasas modificadas. |
| EP0958833A1 (en) * | 1998-05-20 | 1999-11-24 | Erasmus Universiteit Rotterdam | Methods and means for preventing or treating inflammation |
| AUPP508798A0 (en) | 1998-08-05 | 1998-08-27 | Biotech Australia Pty Limited | Method of treating psoriasis |
| AU2001238721A1 (en) * | 2000-03-03 | 2001-09-17 | Zymogenetics Inc. | Human serine protease |
| US6673623B1 (en) | 2000-09-12 | 2004-01-06 | Novocure, Inc. | Methods and compositions that control lipid production |
| AU2002305052A1 (en) | 2001-03-13 | 2002-09-24 | Corvas International, Inc. | Nucleic acid molecules encoding a transmembrane serine protease 7, the encoded polypeptides and methods based thereon |
| KR20040011480A (ko) | 2001-03-22 | 2004-02-05 | 덴드레온 샌 디에고 엘엘씨 | 세린 프로테아제 ｃｖｓｐ14를 암호화하는 핵산 분자,암호화된 폴리펩티드 및 이에 근거한 방법 |
| CA2442089A1 (en) | 2001-03-27 | 2002-10-03 | Dendreon San Diego Llc | Nucleic acid molecules encoding a transmembran serine protease 9, the encoded polypeptides and methods based thereon |
| KR20040080940A (ko) | 2001-05-14 | 2004-09-20 | 덴드레온 코포레이션 | 트랜스막 세린 프로테아제 10을 암호화하는 핵산 분자,암호화된 폴리펩티드 및 이에 근거한 방법 |
| US20050137094A1 (en) * | 2001-06-11 | 2005-06-23 | Halliburton Energy Sevices, Inc. | Subterranean formation treatment fluids and methods of using such fluids |
| US6488091B1 (en) * | 2001-06-11 | 2002-12-03 | Halliburton Energy Services, Inc. | Subterranean formation treating fluid concentrates, treating fluids and methods |
| US7001872B2 (en) * | 2001-06-11 | 2006-02-21 | Halliburton Energy Services, Inc. | Subterranean formation treating fluid and methods of fracturing subterranean formations |
| WO2003004681A2 (en) * | 2001-07-03 | 2003-01-16 | Dendreon San Diego Llc | Nucleic acid molecules encoding a transmembrane serine protease 20, the encoded polypeptides and methods based thereon |
| WO2003053921A2 (en) * | 2001-07-18 | 2003-07-03 | American Red Cross | Mutant proteinase inhibitors and uses thereof |
| RU2247777C2 (ru) * | 2001-07-27 | 2005-03-10 | Общество с ограниченной ответственностью "Научно-производственное предприятие "Техноген" | Модифицированный активатор плазминогена урокиназного типа, последовательность днк, рекомбинантная плазмида, штамм-продуцент, способ получения модифицированного активатора плазминогена урокиназного типа и фармацевтическая композиция, обладающая тромболитическим действием |
| AU2002357004A1 (en) * | 2001-11-20 | 2003-06-10 | Dendreon San Diego Llc | Nucleic acid molecules encoding serine protease 17, the encoded polypeptides and methods based thereon |
| US20040001801A1 (en) * | 2002-05-23 | 2004-01-01 | Corvas International, Inc. | Conjugates activated by cell surface proteases and therapeutic uses thereof |
| CN1798838B (zh) * | 2003-04-04 | 2012-01-04 | 洛桑大学 | 一种蛋白酶的抑制剂蛋白及其用途 |
| MX2008016221A (es) * | 2006-07-05 | 2009-02-23 | Catalyst Biosciences Inc | Métodos de selección de proteasa y proteasas identificadas por este medio. |
| PE20211664A1 (es) * | 2018-12-28 | 2021-08-26 | Catalyst Biosciences Inc | Polipeptidos de activador de plasminogeno, tipo urocinasa, modificados y metodos de uso |
| US11613744B2 (en) | 2018-12-28 | 2023-03-28 | Vertex Pharmaceuticals Incorporated | Modified urokinase-type plasminogen activator polypeptides and methods of use |
| CN112375131B (zh) * | 2020-11-16 | 2021-10-01 | 西南大学 | Seroin蛋白的截短体及其应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5112755A (en) * | 1982-04-15 | 1992-05-12 | Genentech, Inc. | Preparation of functional human urokinase proteins |
| GR79202B (en22) * | 1982-05-05 | 1984-10-22 | Genentech Inc | |
| AU560584B2 (en) * | 1983-07-28 | 1987-04-09 | Bayer Aktiengesellschaft | Homologues of aprotinin |
| US5073494A (en) * | 1985-04-22 | 1991-12-17 | Genentech, Inc. | Human tissue plasminogen activator substituted at position 275 or at positions 275 and 277 |
| JPH084501B2 (ja) * | 1987-03-20 | 1996-01-24 | エーザイ株式会社 | 糖鎖に関する変異ｔＰＡ |
| MY103358A (en) * | 1987-04-15 | 1993-06-30 | Novartis Ag | Process for the production of protiens. |
| EP0292009A1 (en) * | 1987-05-22 | 1988-11-23 | Zymogenetics, Inc. | Fibrinolytic proteins |
| US5200340A (en) * | 1987-05-22 | 1993-04-06 | Zymogenetics, Inc. | Thrombin-activated tissue plasminogen activators |
| GB2208511A (en) * | 1987-08-07 | 1989-04-05 | Bayer Ag | Variants of bovine pancreatic trypsin inhibitor produced by recombinant dna technology |
| EP0330700B1 (en) * | 1987-08-19 | 1993-12-22 | Sagami Chemical Research Center | Human prourokinase-like polypeptide |
| JPH03505276A (ja) * | 1988-02-05 | 1991-11-21 | ジェンザイム・コーポレーション | 再配列された組織プラスミノーゲン活性化因子及びその産生方法 |
| WO1989007145A1 (en) * | 1988-02-05 | 1989-08-10 | Integrated Genetics, Inc. | Modified gene sequences encoding modified tpa and products therefrom |
| US5108901A (en) * | 1988-09-02 | 1992-04-28 | Genentech, Inc. | Tissue plasminogen activator having zymogenic or fibrin specific properties |
| US5262170A (en) * | 1988-09-02 | 1993-11-16 | Genentech, Inc. | Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells |
-
1990
- 1990-03-01 EP EP00109138A patent/EP1029921B1/en not_active Expired - Lifetime
- 1990-03-01 CA CA002047702A patent/CA2047702C/en not_active Expired - Lifetime
- 1990-03-01 DE DE69033699T patent/DE69033699T2/de not_active Expired - Lifetime
- 1990-03-01 JP JP2505024A patent/JP2991769B2/ja not_active Expired - Lifetime
- 1990-03-01 DK DK00109138T patent/DK1029921T3/da active
- 1990-03-01 ES ES90905081T patent/ES2154629T3/es not_active Expired - Lifetime
- 1990-03-01 ES ES00109138T patent/ES2185529T3/es not_active Expired - Lifetime
- 1990-03-01 AU AU52780/90A patent/AU637791B2/en not_active Expired
- 1990-03-01 WO PCT/US1990/000947 patent/WO1990010649A1/en active IP Right Grant
- 1990-03-01 DK DK90905081T patent/DK0462207T3/da active
- 1990-03-01 EP EP90905081A patent/EP0462207B1/en not_active Expired - Lifetime
- 1990-03-01 DE DE69034013T patent/DE69034013T2/de not_active Expired - Lifetime
- 1990-03-01 AT AT90905081T patent/ATE199090T1/de not_active IP Right Cessation
- 1990-03-01 AT AT00109138T patent/ATE226636T1/de not_active IP Right Cessation
-
1996
- 1996-05-21 US US08/651,055 patent/US5728564A/en not_active Expired - Lifetime
-
1999
- 1999-07-23 JP JP11209809A patent/JP3076035B2/ja not_active Expired - Lifetime
- 1999-07-23 JP JP11209788A patent/JP3076034B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DK0462207T3 (da) | 2001-06-18 |
| JP3076034B2 (ja) | 2000-08-14 |
| WO1990010649A1 (en) | 1990-09-20 |
| JPH04504952A (ja) | 1992-09-03 |
| DK1029921T3 (da) | 2003-02-24 |
| ES2154629T3 (es) | 2001-04-16 |
| JP2000037195A (ja) | 2000-02-08 |
| AU637791B2 (en) | 1993-06-10 |
| ATE226636T1 (de) | 2002-11-15 |
| DE69033699T2 (de) | 2001-05-23 |
| ES2185529T3 (es) | 2003-05-01 |
| CA2047702A1 (en) | 1990-09-07 |
| AU5278090A (en) | 1990-10-09 |
| ATE199090T1 (de) | 2001-02-15 |
| DE69034013D1 (de) | 2002-11-28 |
| US5728564A (en) | 1998-03-17 |
| EP1029921A1 (en) | 2000-08-23 |
| DE69034013T2 (de) | 2003-07-31 |
| DE69033699D1 (de) | 2001-03-15 |
| JP2000078990A (ja) | 2000-03-21 |
| JP2991769B2 (ja) | 1999-12-20 |
| EP1029921B1 (en) | 2002-10-23 |
| EP0462207B1 (en) | 2001-02-07 |
| EP0462207A1 (en) | 1991-12-27 |
| JP3076035B2 (ja) | 2000-08-14 |
| EP0462207A4 (en) | 1992-06-24 |
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| Date | Code | Title | Description |
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| EEER | Examination request | ||
| MKEX | Expiry |