CA2044612A1 - Methode de preparation d'alpha-6-desoxytetracyclines - Google Patents

Methode de preparation d'alpha-6-desoxytetracyclines

Info

Publication number
CA2044612A1
CA2044612A1 CA 2044612 CA2044612A CA2044612A1 CA 2044612 A1 CA2044612 A1 CA 2044612A1 CA 2044612 CA2044612 CA 2044612 CA 2044612 A CA2044612 A CA 2044612A CA 2044612 A1 CA2044612 A1 CA 2044612A1
Authority
CA
Canada
Prior art keywords
rhodium
alpha
hydrogenation
catalyst
methacycline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2044612
Other languages
English (en)
Inventor
George Krsek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Houba Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2044612A1 publication Critical patent/CA2044612A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
CA 2044612 1989-01-04 1990-01-02 Methode de preparation d'alpha-6-desoxytetracyclines Abandoned CA2044612A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29322489A 1989-01-04 1989-01-04
US07/293,224 1989-01-04

Publications (1)

Publication Number Publication Date
CA2044612A1 true CA2044612A1 (fr) 1990-07-05

Family

ID=23128217

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2044612 Abandoned CA2044612A1 (fr) 1989-01-04 1990-01-02 Methode de preparation d'alpha-6-desoxytetracyclines

Country Status (4)

Country Link
EP (1) EP0452412A4 (fr)
JP (1) JP2665395B2 (fr)
CA (1) CA2044612A1 (fr)
WO (1) WO1990007492A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006272698B2 (en) * 2005-07-21 2012-11-01 Paratek Pharmaceuticals, Inc. 10-substituted tetracyclines and methods of use thereof
CN113248397B (zh) * 2021-07-01 2021-11-05 山东国邦药业有限公司 一种盐酸多西环素的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3954862A (en) * 1973-04-20 1976-05-04 Pfizer Inc. Process for producing α-6-deoxytetracyclines
DK386784A (da) * 1983-08-17 1985-02-18 Hovione Int Ltd Fremgangsmaade til fremstilling af alfa-6-desoxy-tetracykliner

Also Published As

Publication number Publication date
EP0452412A1 (fr) 1991-10-23
EP0452412A4 (en) 1992-06-03
JPH04504412A (ja) 1992-08-06
JP2665395B2 (ja) 1997-10-22
WO1990007492A1 (fr) 1990-07-12

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead