CA2025009A1 - Antiviral compounds - Google Patents

Antiviral compounds

Info

Publication number
CA2025009A1
CA2025009A1 CA002025009A CA2025009A CA2025009A1 CA 2025009 A1 CA2025009 A1 CA 2025009A1 CA 002025009 A CA002025009 A CA 002025009A CA 2025009 A CA2025009 A CA 2025009A CA 2025009 A1 CA2025009 A1 CA 2025009A1
Authority
CA
Canada
Prior art keywords
group
compound
fluoro
formula
deoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002025009A
Other languages
English (en)
French (fr)
Inventor
Sylvia M Tisdale
Joel Van Tuttle
Martin J. Slater
Susan M Daluge
Wayne H. Miller
Thomas A. Krenitsky
George W. Koszalka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2025009A1 publication Critical patent/CA2025009A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/173—Purine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Local Oxidation Of Silicon (AREA)
  • Element Separation (AREA)
CA002025009A 1989-09-11 1990-09-10 Antiviral compounds Abandoned CA2025009A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898920534A GB8920534D0 (en) 1989-09-11 1989-09-11 Antiviral compounds
GB8920534.8 1989-09-11

Publications (1)

Publication Number Publication Date
CA2025009A1 true CA2025009A1 (en) 1991-03-12

Family

ID=10662891

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002025009A Abandoned CA2025009A1 (en) 1989-09-11 1990-09-10 Antiviral compounds

Country Status (19)

Country Link
EP (2) EP0671410A1 (OSRAM)
JP (1) JPH03145497A (OSRAM)
KR (1) KR910006293A (OSRAM)
AT (1) ATE135365T1 (OSRAM)
AU (1) AU644095B2 (OSRAM)
CA (1) CA2025009A1 (OSRAM)
DD (1) DD297650A5 (OSRAM)
DE (1) DE69025834D1 (OSRAM)
FI (1) FI904445A7 (OSRAM)
GB (1) GB8920534D0 (OSRAM)
HU (1) HUT54704A (OSRAM)
IE (1) IE903269A1 (OSRAM)
MY (1) MY130035A (OSRAM)
NZ (1) NZ235244A (OSRAM)
PL (1) PL164967B1 (OSRAM)
PT (1) PT95261A (OSRAM)
RU (2) RU2043361C1 (OSRAM)
TW (2) TW246641B (OSRAM)
ZA (1) ZA907187B (OSRAM)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI95384C (fi) * 1989-04-06 1996-01-25 Squibb Bristol Myers Co Menetelmä 3'-deoksi-3'-substituoitujen metyylinukleosidien valmistamiseksi ja menetelmässä käytettäviä välituotteita
US5859221A (en) * 1990-01-11 1999-01-12 Isis Pharmaceuticals, Inc. 2'-modified oligonucleotides
US6399754B1 (en) 1991-12-24 2002-06-04 Isis Pharmaceuticals, Inc. Sugar modified oligonucleotides
US5914396A (en) * 1990-01-11 1999-06-22 Isis Pharmaceuticals, Inc. 2'-O-modified nucleosides and phosphoramidites
US6005087A (en) * 1995-06-06 1999-12-21 Isis Pharmaceuticals, Inc. 2'-modified oligonucleotides
US5872232A (en) * 1990-01-11 1999-02-16 Isis Pharmaceuticals Inc. 2'-O-modified oligonucleotides
US5670633A (en) * 1990-01-11 1997-09-23 Isis Pharmaceuticals, Inc. Sugar modified oligonucleotides that detect and modulate gene expression
WO1991015498A2 (en) * 1990-04-04 1991-10-17 Nycomed Imaging As Nucleoside derivatives
US5378825A (en) * 1990-07-27 1995-01-03 Isis Pharmaceuticals, Inc. Backbone modified oligonucleotide analogs
US5677437A (en) * 1990-07-27 1997-10-14 Isis Pharmaceuticals, Inc. Heteroatomic oligonucleoside linkages
US5610289A (en) * 1990-07-27 1997-03-11 Isis Pharmaceuticals, Inc. Backbone modified oligonucleotide analogues
US5618704A (en) * 1990-07-27 1997-04-08 Isis Pharmacueticals, Inc. Backbone-modified oligonucleotide analogs and preparation thereof through radical coupling
US5623070A (en) 1990-07-27 1997-04-22 Isis Pharmaceuticals, Inc. Heteroatomic oligonucleoside linkages
US5792844A (en) * 1990-07-27 1998-08-11 Isis Pharmaceuticals, Inc. Oligonucleoside linkages containing adjacent nitrogen atoms
AU1254892A (en) * 1990-12-18 1992-07-22 Sloan-Kettering Institute For Cancer Research Novel synthesis of 2'-"up" fluorinated 2''-deoxy-arabinofuranosylpurines
US5672697A (en) * 1991-02-08 1997-09-30 Gilead Sciences, Inc. Nucleoside 5'-methylene phosphonates
US5965722A (en) * 1991-05-21 1999-10-12 Isis Pharmaceuticals, Inc. Antisense inhibition of ras gene with chimeric and alternating oligonucleotides
US7119184B2 (en) 1991-08-12 2006-10-10 Isis Pharmaceuticals, Inc. Oligonucleotides having A-DNA form and B-DNA form conformational geometry
US6307040B1 (en) 1992-03-05 2001-10-23 Isis Pharmaceuticals, Inc. Sugar modified oligonucleotides that detect and modulate gene expression
US5393841A (en) * 1993-11-09 1995-02-28 Shell Oil Company Dissimilar arm asymmetric radial or star block copolymers for adhesives and sealants
US8075760B2 (en) 1995-06-19 2011-12-13 Lifescan, Inc. Electrochemical cell
US6413410B1 (en) 1996-06-19 2002-07-02 Lifescan, Inc. Electrochemical cell
US5898031A (en) 1996-06-06 1999-04-27 Isis Pharmaceuticals, Inc. Oligoribonucleotides for cleaving RNA
US7812149B2 (en) 1996-06-06 2010-10-12 Isis Pharmaceuticals, Inc. 2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations
US9096636B2 (en) 1996-06-06 2015-08-04 Isis Pharmaceuticals, Inc. Chimeric oligomeric compounds and their use in gene modulation
DK0917879T3 (da) * 1997-11-22 2002-11-04 Roche Diagnostics Gmbh Forbedret fremgangsmåde til stabilisering af proteiner
YU44900A (sh) 1998-01-31 2003-01-31 Glaxo Group Limited Derivati 2-(purin-9-il)tetrahidrofuran-3,4-diola
EP1058686B1 (en) * 1998-02-25 2006-11-02 Emory University 2'-fluoronucleosides
JP2004533406A (ja) 2000-10-18 2004-11-04 フアーマセツト・リミテツド ウイルス感染症および異常細胞増殖を治療するための修飾ヌクレオシド
US7132453B2 (en) 2002-03-15 2006-11-07 Vanderbilt University Method of using prostacyclin to treat respiratory syncytial virus infections
WO2004043979A2 (en) 2002-11-05 2004-05-27 Isis Pharmaceuticals, Inc. Sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
US8569474B2 (en) 2004-03-09 2013-10-29 Isis Pharmaceuticals, Inc. Double stranded constructs comprising one or more short strands hybridized to a longer strand
US8394947B2 (en) 2004-06-03 2013-03-12 Isis Pharmaceuticals, Inc. Positionally modified siRNA constructs
US7884086B2 (en) 2004-09-08 2011-02-08 Isis Pharmaceuticals, Inc. Conjugates for use in hepatocyte free uptake assays
WO2008109080A2 (en) * 2007-03-01 2008-09-12 Siemens Medical Solutions Usa, Inc. Nucleoside based proliferation imaging markers
EP3424939A1 (en) 2009-03-02 2019-01-09 Alnylam Pharmaceuticals Inc. Nucleic acid chemical modifications
WO2011123621A2 (en) 2010-04-01 2011-10-06 Alnylam Pharmaceuticals Inc. 2' and 5' modified monomers and oligonucleotides
EP2937420A1 (en) * 2014-04-23 2015-10-28 Synbias Pharma AG Method for the synthesis of clofarabine
JP6983814B2 (ja) * 2016-12-14 2021-12-17 ヤマサ醤油株式会社 抗ウイルス活性を示すヌクレオシド誘導体

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4751221A (en) * 1985-10-18 1988-06-14 Sloan-Kettering Institute For Cancer Research 2-fluoro-arabinofuranosyl purine nucleosides
CA1340645C (en) * 1987-04-17 1999-07-13 Victor E. Marquez Acid stable dideoxynucleosides active against the cytopathic effects of human immunodeficiency virus

Also Published As

Publication number Publication date
HUT54704A (en) 1991-03-28
IE903269A1 (en) 1991-03-27
RU2043361C1 (ru) 1995-09-10
MY130035A (en) 2007-05-31
ATE135365T1 (de) 1996-03-15
PL164967B1 (pl) 1994-10-31
ZA907187B (en) 1992-05-27
JPH03145497A (ja) 1991-06-20
PT95261A (pt) 1991-05-22
TW246641B (OSRAM) 1995-05-01
AU6235090A (en) 1991-03-14
EP0417999A1 (en) 1991-03-20
EP0671410A1 (en) 1995-09-13
AU644095B2 (en) 1993-12-02
GB8920534D0 (en) 1989-10-25
DD297650A5 (de) 1992-01-16
FI904445A7 (fi) 1991-03-12
EP0417999B1 (en) 1996-03-13
FI904445A0 (fi) 1990-09-10
PL286820A1 (en) 1991-04-22
RU94002475A (ru) 1996-11-10
TW226333B (OSRAM) 1994-07-11
NZ235244A (en) 1992-11-25
DE69025834D1 (de) 1996-04-18
KR910006293A (ko) 1991-04-29

Similar Documents

Publication Publication Date Title
EP0417999B1 (en) Antiviral compounds
AU738170B2 (en) Monocyclic L-nucleosides, analogs and uses thereof
AP457A (en) 2,6-Diaminopurine derivatives.
AU750462B2 (en) 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives
US4780453A (en) Treatment of feline viral infections
CA1336820C (en) Fluorinated nucleosides and process for treating retrovirus infections therewith
EP1572705A2 (en) Sugar modified nucleosides as viral replication inhibitors
JPS62161797A (ja) ２′−フルオロ−アラビノフラノシルプリンヌクレオシド
HUP0101305A2 (hu) 2-(Purin-9-il)-tetrahidrofurán-3,4-diol-származékok, eljárás az előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények
US5661136A (en) 2-halo-2'-fluoro ARA adenosines as antinoplastic agents
NO171506B (no) Analogifremgangsmaate ved fremstilling av terapeutisk aktive adenosin-derivater
HU199870B (en) Process for producing purine arabinoside derivatives with antiviral effect and pharmaceutical compositions comprising same
US5420115A (en) Method for the treatment of protoza infections with 21 -deoxy-21 -fluoropurine nucleosides
JPH06228186A (ja) ２’−デオキシ−（２’ｓ）−アルキルピリミジンヌクレオシド誘導体
US3014900A (en) Process for the preparation of ketosidopurines
WO1999043690A1 (en) L-4'-arabinofuranonucleoside compound and medicine composition comprising the same
US7595390B2 (en) Industrially scalable nucleoside synthesis
US5153180A (en) Fluorinated nucleosides and process for treating retrovirus infections therewith
JP2001335592A (ja) ４’−ｃ−エチニルプリンヌクレオシド化合物
US20060173174A1 (en) Difluoronucleosides and process for preparation thereof
EP0445258B1 (en) 5'-alkylphosphonylnucleosides as antivirals
RU2112765C1 (ru) ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ПРОЯВЛЯЮЩАЯ АКТИВНОСТЬ ПРОТИВ ВИРУСНОЙ ИНФЕКЦИИ И β D-АРАБИНОФУРАНОЗИЛ-2-АМИНО-6-МЕТОКСИ-9Н-ПУРИНЫ
JP2001335593A (ja) ４’−ｃ−エチニルピリミジンヌクレオシド化合物
US5145840A (en) Treatment of idiopathic thrombocytopaenic purpura
JPWO1999043690A1 (ja) Ｌ−４′−チオアラビノフラノヌクレオシド化合物およびそれを含む医薬組成物

Legal Events

Date Code Title Description
FZDE Discontinued